# bib

id: cord-263247-r3t4uowz
author: Ly, Hinh
title: Lassa Fever: Viral Replication, Disease Pathogenesis, and Host Immune Modulations
date: 2020-06-03
extension: .txt
mime: text/plain
words: 1124
sentence: 27
flesch: 31
cache: cache/cord-263247-r3t4uowz.txt
txt: txt/cord-263247-r3t4uowz.txt
summary:
  Improving the Breadth of the Host's Immune Response to Lassa Virus Virus-Host Interactions Involved in Lassa Virus Entry and Genome Replication. Pathogens A Single Dose of Modified Vaccinia Ankara Expressing Lassa Virus-like Particles Protects Mice from Lethal Intra-cerebral Virus Challenge Attenuated Replication of Lassa Virus Vaccine Candidate ML29 in STAT-1 -/-Mice.


id: cord-272295-9sonr8or
author: Lechien, Jerome R.
title: Objective Olfactory Findings in Hospitalized Severe COVID-19 Patients
date: 2020-07-31
extension: .txt
mime: text/plain
words: 1691
sentence: 83
flesch: 44
cache: cache/cord-272295-9sonr8or.txt
txt: txt/cord-272295-9sonr8or.txt
summary:
  Methods: Severe COVID-19 patients with self-reported SLS were recruited at hospitalization discharge. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): A multicenter European study Smell dysfunction: A biomarker for COVID-19 Objective olfactory evaluation of self-reported loss of smell in a case series of 86 COVID-19 patients Olfactory and gustatory function impairment in COVID-19 patients: Italian objective multicenter-study Loss of Smell and Taste in 2013 European Mild-to-Moderation COVID-19 Patients French adaptation and validation of the sino-nasal outcome test-22: A prospective cohort study on quality of life among 422 subjects Immunology of COVID-19:


id: cord-322807-b24ujorz
author: Koyama, Takahiko
title: Emergence of Drift Variants That May Affect COVID-19 Vaccine Development and Antibody Treatment
date: 2020-04-26
extension: .txt
mime: text/plain
words: 1872
sentence: 76
flesch: 45
cache: cache/cord-322807-b24ujorz.txt
txt: txt/cord-322807-b24ujorz.txt
summary:
  Among the twelve variants in the B-cell epitopes, 23403A>G variant (p.D614G) in one of the epitopes in spike protein between residue 601 and 640 stands out, with 175 samples in 615 total samples. Consideration of drift variants in SARS-CoV-2 will offer cross-protection across different sub-strains and obviate the need for reformulation of the vaccine for each distinct sub-strain.


id: cord-266145-xnu8pj24
author: Ahmed, Mohammed A. M.
title: COVID-19 in Somalia: Adherence to Preventive Measures and Evolution of the Disease Burden
date: 2020-09-06
extension: .txt
mime: text/plain
words: 3289
sentence: 120
flesch: 43
cache: cache/cord-266145-xnu8pj24.txt
txt: txt/cord-266145-xnu8pj24.txt
summary:
  Two consecutive cross-sectional surveys investigating the adherence to COVID-19 preventive measures were conducted. A multivariable model investigating factors associated with the adherence score to COVID-19 preventive measures found that being a female, healthcare worker/student, and obtaining COVID-19 information from official sources significantly increased the odds for higher adherence (Table 7 ).


id: cord-294571-qd0qjo3y
author: Rothan, Hussin A.
title: Molecular Aspects of COVID-19 Differential Pathogenesis
date: 2020-07-06
extension: .txt
mime: text/plain
words: 3258
sentence: 119
flesch: 35
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summary:
  key: cord-294571-qd0qjo3y authors: Rothan, Hussin A.; Acharya, Arpan; Reid, St Patrick; Kumar, Mukesh; Byrareddy, Siddappa N. title: Molecular Aspects of COVID-19 Differential Pathogenesis date: 2020-07-06 journal: Pathogens DOI: 10.3390/pathogens9070538 sha: doc_id: 294571 cord_uid: qd0qjo3y In the absence of therapeutic interventions, and a possible vaccine candidate, the spread of COVID-19 disease and associated fatalities are on the rise. There are no effective vaccines or specific antiviral drugs available to manage COVID-19 disease.


id: cord-293988-f5gvwjyh
author: Musso, Nicolò
title: New SARS-CoV-2 Infection Detected in an Italian Pet Cat by RT-qPCR from Deep Pharyngeal Swab
date: 2020-09-11
extension: .txt
mime: text/plain
words: 3229
sentence: 119
flesch: 44
cache: cache/cord-293988-f5gvwjyh.txt
txt: txt/cord-293988-f5gvwjyh.txt
summary:
  In particular, viral RNA and infectious viral particles were found in the upper respiratory tract of domestic cats after introduction of SARS-CoV-2 virus samples through their nasal cavities; nevertheless, none of the infected cats showed clinical signs of the disease. In addition, viral RNA was detected in 1:3 healthy cats exposed to infected felines, suggesting that they had contracted the virus from the droplets exhaled by infected cats [13, 19] .


id: cord-298505-r7ihqb96
author: Górski, Andrzej
title: Sepsis, Phages, and COVID-19
date: 2020-10-15
extension: .txt
mime: text/plain
words: 3741
sentence: 169
flesch: 41
cache: cache/cord-298505-r7ihqb96.txt
txt: txt/cord-298505-r7ihqb96.txt
summary:
  Thus, clinical trials assessing the value of phage therapy in sepsis, including viral sepsis, are urgently needed. In this review, we summarize the progress in treating sepsis with phage therapy over the last three years.


id: cord-330827-gu2mt6zp
author: Shanmugaraj, Balamurugan
title: Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development
date: 2020-02-22
extension: .txt
mime: text/plain
words: 3748
sentence: 125
flesch: 32
cache: cache/cord-330827-gu2mt6zp.txt
txt: txt/cord-330827-gu2mt6zp.txt
summary:
  [60] [61] , the monoclonal antibodies that are identified and tested to be effective against SARS virus protein or specific to ACE2 can be produced in plants and shall be tested for its efficacy against nCoV. Earlier reports showed several vaccines and monoclonal antibody candidates in response to SARS-CoV and MERS-CoV, which could be tested and used for passive immunotherapy for an immediate immune response [62] [63] Currently, plant expression system offers many advantages over other conventional systems that have the potential to tackle the production of vaccine candidates rapidly at affordable cost facilitating the global vaccination programs, especially in resource-poor nations where the vaccines are needed most [15] .


id: cord-274497-tqceazdp
author: N. Nuñez, Luis Fabian
date: 2020-07-25
extension: .txt
mime: text/plain
words: 4125
sentence: 154
flesch: 42
cache: cache/cord-274497-tqceazdp.txt
txt: txt/cord-274497-tqceazdp.txt
title:
  Molecular Characterization and Pathogenicity of Chicken Parvovirus (ChPV) in Specific Pathogen-Free Chicks Infected Experimentally

summary:
  Molecular characterization and typing of chicken and turkey astroviruses circulating in the United States: Implications for diagnostics Partial genome sequence analysis of parvoviruses associated with enteric disease in poultry Molecular characterization of avian astroviruses Host Specificity and Phylogenetic Relationships of Chicken and Turkey Parvoviruses Enteric Virus Diversity Examined by Molecular Methods in Brazilian Poultry Flocks Development of a sensitive real-time Fast-qPCR Based on SYBR ® green for detection and quantification of Chicken Parvovirus (ChPV) Detection of rotaviruses and intestinal lesions in broiler chicks from flocks with runting and stunting syndrome (RSS) Detection of chicken astrovirus by reverse transcriptase-polymerase chain reaction Development and evaluation of real-time TaqMan ® RT-PCR assays for the detection of avian nephritis virus and chicken astrovirus in chickens Emergence of Enteric Viruses in Production Chickens is a Concern for Avian Health Capsid protein sequence diversity of avian nephritis virus Chicken astrovirus as an aetiological agent of runting-stunting syndrome in broiler chickens Presence of parvoviruses in the intestine of chickens showing stunting syndrome Experimental infection of chicken embryos and day-old chickens with parvovirus of chicken origin High prevalence of turkey parvovirus in turkey flocks from Hungary experiencing enteric disease syndromes Samorek-Salamonowicz, E. Occurrence of chicken parvovirus infection in poland Parvovirus host range, cell tropism and evolution Recent Progress in the Characterization of Avian Enteric Viruses Determination and analysis of the full-length chicken parvovirus genome Identification and phylogenetic diversity of parvovirus circulating in commercial chicken and turkey flocks in Croatia Molecular detection of chicken parvovirus in broilers with enteric disorders presenting curving of duodenal loop, pancreatic atrophy, and mesenteritis Chicken parvovirus-induced runting-stunting syndrome in young broilers Genetic characterization of three novel chicken parvovirus strains based on analysis of their coding sequences Development of an Enzyme-Linked Immunosorbent Assay to Detect Chicken Parvovirus-Specific Antibodies Development of a Polymerase Chain Reaction Procedure for Detection of Chicken and Turkey Parvoviruses A novel tool for specific detection and quantification of chicken/turkey parvoviruses to trace poultry fecal contamination in the environment Chicken parvovirus viral loads in cloacal swabs from malabsorption syndrome-affected and healthy broilers Avian parvovirus: Classification, phylogeny, pathogenesis and diagnosis Genetic characterization of parvoviruses circulating in turkey and chicken flocks in Poland Naturally occurring parvoviral infection in Hungarian broiler flocks Investigation into the aetiology of runting and stunting syndrome in chickens Periodic Monitoring of Commercial Turkeys for Enteric Viruses Indicates Continuous Presence of Astrovirus and Rotavirus on the Farms Phylogenetic diversity of avian nephritis virus in Hungarian chicken flocks Detection of enteric viruses in pancreas and spleen of broilers with runting-stunting syndrome (RSS) Isolation and molecular characterisation of chicken parvovirus from Brazilian flocks with enteric disorders MEGA7: The lack of ChPV VP1 gene sequences could likely be related to the difficulty in ChPV DNA isolation for whole VP1 gene sequencing; however, the majority of published works have included a molecular characterization of the NS gene sequence [15, 16] .


id: cord-298862-8bijio30
author: Eltom, Kamal H.
title: Buffalopox Virus: An Emerging Virus in Livestock and Humans
date: 2020-08-20
extension: .txt
mime: text/plain
words: 4325
sentence: 191
flesch: 43
cache: cache/cord-298862-8bijio30.txt
txt: txt/cord-298862-8bijio30.txt
summary:
  Ninth Report of the International Committee on Taxonomy of Viruses Family Poxviridae Generalised buffalopox An experimental study of virus of buffalopox Isolation and characterization of the aetiologic agent of buffalopox Virus study of pock disease among buffaloes Buffalopox virus Isolation, cultivation and characterization of poxviruses from Egyptian water buffaloes An emerging and re-emerging zoonosis Partial genetic characterization of viruses isolated from pox-like infection in cattle and buffaloes: Evidence of buffalo pox virus circulation in Indian cows A study of the ultrastructure of the buffalo pox virus Comparative studies on cultivation of buffalo pox virus in pup kidney and chicken embryo fibroblast cell culture Isolation of buffalo poxvirus from clinical case and variations in the genetics of the B5R gene over fifty passages Buffalo pox outbreak with atypical features: A word of caution and need for early intervention! Laboratory-acquired buffalopox virus infection An outbreak of buffalopox in buffalo (Bubalus bubalis) dairy herds in Aurangabad Virological investigations of specimens from buffaloes affected by buffalopox in Maharashtra State, India between 1985 and 1987 B5r gene based sequence analysis of Indian buffalopox virus isolates in relation to other orthopoxviruses Comparative sequence analysis of envelope protein genes of Indian buffalopox virus isolates Isolation and phylogenomic analysis of buffalopox virus from human and buffaloes in India Orthopoxviruses-Plagues of Mankind, Strategists in Immune Evasion, Teachers in Vaccination Characteristics of a new poxvirus isolated from Indian buffaloes Smallpox and Its Eradication; World Health Organization Sequence and phylogenetic analysis of host-range (E3L, K3L, and C7L) and structural protein (B5R) genes of buffalopox virus isolates from buffalo, cattle, and human in India Buffalopox-a review Zoonotic infections of buffalopox in India A case report of buffalopox: A zoonosis of concern Buffalopox outbreak in humans and animals in Western Maharashtra Isolation and molecular characterization of zoonotic Buffalopox virus from skin lesions of humans in India Buffalo pox infection in man Emergence and reemergence of vaccinia-like viruses: Global scenario and perspectives Sequence analysis of C18L gene of buffalopox virus: PCR strategy for specific detection and differentiation of buffalopox from orthopoxviruses Investigation of buffalopox outbreaks in Maharashtra State during 1992-1996 Poxvirus tropism Vaccinia virus host range genes Poxviruses and immune evasion The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase Vaccinia virus E3 protein prevents the antiviral action of ISG15 The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2 Poxvirus genomes: A phylogenetic analysis Cellular and biochemical differences between two attenuated poxvirus vaccine candidates (MVA and NYVAC) and role of the C7L gene Vaccinia virus K1L and C7L inhibit antiviral activities induced by type I interferons Significance of extracellular enveloped virus in the in vitro and in vivo dissemination of vaccinia Vaccinia virus complement-control protein prevents antibody-dependent complement-enhanced neutralization of infectivity and contributes to virulence Deletion of the vaccinia virus B5R gene encoding a 42-kilodalton membrane glycoprotein inhibits extracellular virus envelope formation and dissemination Real time PCR: A rapid tool for potency estimation of live attenuated camelpox and buffalopox vaccines An investigation of buffalopox outbreak in animals and human beings in Dhulia District (Maharashtra State). 2. Epidemiological studies Outbreak of human buffalopox infection Epitope detection in the envelope of intracellular naked orthopox viruses and identification of encoding genes Partial antigenic characterization of buffalopox virus Structural analysis and immunogenicity of recombinant major envelope protein (rA27L) of buffalopox virus, a zoonotic Indian vaccinia-like virus Immunogenicity and protective efficacy of recombinant major envelope protein (rH3L) of buffalopox virus in animal models Animal poxviruses transmitted from cat to man: Current event with lethal end Fatal cowpox-like virus infection transmitted by cat In vitro and in silico biological studies of novel thiazolo[3,2-a]pyrimidine-6-carboxylate derivatives MNK1 inhibitor as an antiviral agent suppresses buffalopox virus protein synthesis Comparison of dried vaccine with fresh Indian buffalo-calf lymph in revaccination against smallpox Summary Report on First, Second and Third Generation Smallpox Vaccines; World Health Organization Co-administration of recombinant major envelope proteins (rA27L and rH3L) of buffalopox virus provides enhanced immunogenicity and protective efficacy in animal models An emergent poxvirus from humans and cattle in Rio de Janeiro State: Cantagalo virus may derive from Brazilian smallpox vaccine Passatempo virus, a vaccinia virus strain Aracatuba virus: A vaccinialike virus associated with infection in humans and cattle Novel Orthopoxvirus Infection in an Alaska Resident Human Monkeypox: Current State of Knowledge and Implications for the Future Human infection with a zoonotic orthopoxvirus in the country of Georgia Fatal Outbreak in Tonkean Macaques Caused by Possibly Novel Orthopoxvirus Novel Orthopoxvirus and Lethal Disease in Cat


id: cord-009445-p2rz81fy
author: Nabil, Nehal M.
date: 2020-03-06
extension: .txt
mime: text/plain
words: 4681
sentence: 180
flesch: 43
cache: cache/cord-009445-p2rz81fy.txt
txt: txt/cord-009445-p2rz81fy.txt
title:
  Wild Birds in Live Birds Markets: Potential Reservoirs of Enzootic Avian Influenza Viruses and Antimicrobial Resistant Enterobacteriaceae in Northern Egypt

summary:
  The presence of enzootic IAV and the wide prevalence of AMR enterobacteriaceae in wild birds highlight the potential role of LBM in the spread of different pathogens from and to wild birds. Wild birds represent a sentinel reservoir for a wide range of viral and bacterial pathogens, with the potential to infect domestic birds and disseminate over long distances in a short time [1] .


id: cord-309147-c3ikb81g
author: Nadeem, Muhammad Shahid
title: Origin, Potential Therapeutic Targets and Treatment for Coronavirus Disease (COVID-19)
date: 2020-04-22
extension: .txt
mime: text/plain
words: 5006
sentence: 206
flesch: 43
cache: cache/cord-309147-c3ikb81g.txt
txt: txt/cord-309147-c3ikb81g.txt
summary:
  A prospective study Influenza A virus shedding and infectivity in households Transmission of 2019-nCoV infection from an asymptomatic contact in Germany Structure, function, and evolution of coronavirus spike proteins Structure of SARS coronavirus spike receptor-binding domain complexed with receptor Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Severe acute respiratory syndrome Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis Mechanisms of host receptor adaptation by severe acute respiratory syndrome coronavirus Design of potent membrane fusion inhibitors against SARS-CoV-2, an emerging coronavirus with high fusogenic activity The novel coronavirus 2019 (COVID-19) uses the SARS-1 coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus: A first step in understanding SARS pathogenesis Potential interventions for novel coronavirus in China: A systematic review Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2 Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein Coronaviruses post-SARS: Update on replication and pathogenesis Recent insights into emerging coronaviruses Therapeutic options for the 2019 novel coronavirus (2019-nCoV) Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics Preliminary identification of potential vaccine targets for the COVID-19 coronavirus (SARS-CoV-2) based on SARS-CoV immunological studies Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein Advances in respiratory virus therapeutics -A meeting report from the 6th isirv Antiviral Group conference Rapid Identification of Potential Inhibitors of SARS-CoV-2 Main Protease by Deep Docking of 1.3 Billion Compounds Identification of SARS-CoV-2 Cell Entry Inhibitors by Drug Repurposing Using in Silico Structure-Based Virtual Screening Approach WHO says vaccines against novel coronavirus 18 months away, pushes global research Can Chinese medicine be used for prevention of Corona virus disease 2019 (COVID-19)? Paving the Road for Rapid Detection and Point-of-Care Diagnostics Rapid colorimetric detection of COVID-19 coronavirus using a reverse tran-scriptional loop-mediated isothermal amplification (RT-LAMP) diagnostic plat-form: iLACO A Single and Two-Stage, Closed-Tube, Molecular Test for the 2019 Novel Coronavirus (COVID-19) at Home, Clinic, and Points of Entry Reverse transcription loop-mediated isothermal amplification combined with nanoparticles-based biosensor for diagnosis of COVID-19 Serological and molecular findings during SARS-CoV-2 infection: The first case study in Finland Molecular immune pathogenesis and diagnosis of COVID-19 A case of COVID-19 and pneumonia returning from Macau in Taiwan: Clinical course and anti-SARS-CoV-2 IgG dynamic Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single-centered, retrospective, observational study The SARS wake-up call Does SARS-CoV-2 has a longer incubation period than SARS and MERS? SARS-CoV infection in a restaurant from palm civet Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human Host and infectivity prediction of Wuhan 2019 novel coronavirus using deep learning algorithm Real-time sequence-validated loop-mediated isothermal amplification assays for detection of Middle East respiratory syndrome coronavirus (MERS-CoV) Development and evaluation of novel real-time reverse transcription-PCR assays with locked nucleic acid probes targeting leader sequences of human-pathogenic coronaviruses COVID-19, an Emerging Coronavirus Infection: Current Scenario and Recent Developments-An Overview Pharmacologic treatment of SARS: Current knowledge and recommendations Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Of chloroquine and COVID-19 Chloroquine and hydroxychloroquine as available weapons to fight COVID-19 Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies Temperature significant change COVID-19 Transmission in 429 cities 2019-Novel coronavirus (2019-nCoV):


id: cord-253116-oq0bc35u
author: Felten, Sandra
title: Correlation of Feline Coronavirus Shedding in Feces with Coronavirus Antibody Titer
date: 2020-07-22
extension: .txt
mime: text/plain
words: 6040
sentence: 219
flesch: 48
cache: cache/cord-253116-oq0bc35u.txt
txt: txt/cord-253116-oq0bc35u.txt
summary:
  Cat samples were tested at dilutions of 1:25, 1:100, 1:400 and 1:1600. Cats shedding FCoV in all four fecal samples had higher FCoV antibody titers and shed higher concentrations of FCoV than cats shedding FCoV intermittently.


id: cord-003767-9xbu4hnq
author: Slingenbergh, Jan
date: 2019-05-25
extension: .txt
mime: text/plain
words: 6289
sentence: 274
flesch: 45
cache: cache/cord-003767-9xbu4hnq.txt
txt: txt/cord-003767-9xbu4hnq.txt
title:
  Animal Virus Ecology and Evolution Are Shaped by the Virus Host-Body Infiltration and Colonization Pattern

summary:
  Less attention is given to why and how virus fitness results from the success of virus transmission. Virus circulation in the bloodstream may enable virus transmission via needles or arthropod vectors [10] .


id: cord-288306-0chcsqe7
author: Wang, Lihua
title: Recent Advances in the Diagnosis of Classical Swine Fever and Future Perspectives
date: 2020-08-15
extension: .txt
mime: text/plain
words: 5836
sentence: 223
flesch: 36
cache: cache/cord-288306-0chcsqe7.txt
txt: txt/cord-288306-0chcsqe7.txt
summary:
  A multiplex reverse transcription PCR and automated electronic microarray assay for detection and differentiation of seven viruses affecting swine Detection system based on magnetoelastic sensor for classical swine fever virus Diagnosis of mixed infections with swine viruses using an integrated microfluidic platform Next-generation sequencing in veterinary medicine: How can the massive amount of information arising from high-throughput technologies improve diagnosis, control, and management of infectious diseases? Next-generation sequencing as diagnostic tool in veterinary research Molecular epidemiology of current classical swine fever virus isolates of wild boar in Germany Sequencing approach to analyze the role of quasispecies for classical swine fever Virus adaptation and selection following challenge of animals vaccinated against classical swine fever virus Classical swine fever virus biology, clinicopathology, diagnosis, vaccines and a meta-analysis of prevalence: A review from the Indian Perspective Pigs immunized with a novel E2 subunit vaccine are protected from heterologous classical swine fever virus challenge Towards the development of a one-dose classical swine fever subunit vaccine: Antigen titration, onset and duration of immunity Plant-made E2 glycoprotein single-dose vaccine protects pigs against classical swine fever A neutralizing monoclonal antibody-based competitive ELISA for classical swine fever C-strain post-vaccination monitoring Development of a high-throughput serum neutralization test using recombinant pestiviruses possessing a small reporter tag Detection of antibodies against classical swine fever virus in swine sera by indirect ELISA using recombinant envelope glycoprotein E2 Direct coating of culture medium from cells secreting classical swine fever virus E2 antigen on ELISA plates for detection of E2-specific antibodies Development of a competitive ELISA using a truncated E2 recombinant protein as antigen for detection of antibodies to classical swine fever virus Development of single dilution immunoassay to detect E2 protein specific classical swine fever virus antibody A multiplex nested RT-PCR for the detection and differentiation of wild-type viruses from C-strain vaccine of classical swine fever virus Evaluation of a multiplex real-time RT-PCR for quantitative and differential detection of wild-type viruses and C-strain vaccine of Classical swine fever virus Differentiation of C-strain Riems or CP7_E2alf vaccinated animals from animals infected by classical swine fever virus field strains using real-time RT-PCR A generic real-time TaqMan assay for specific detection of lapinized Chinese vaccines against classical swine fever Development of a triplex TaqMan real-time RT-PCR assay for differential detection of wild-type and HCLV vaccine strains of classical swine fever virus and bovine viral diarrhea virus 1 Differential detection of classical swine fever virus challenge strains in C-strain vaccinated pigs Comparison of two real-time RT-PCR assays for differentiation of C-strain vaccinated from classical swine fever infected pigs and wild boars Development of a reverse-transcription polymerase chain reaction assay with fluorogenic probes to discriminate Korean wild-type and vaccine isolates of Classical swine fever virus Rapid detection and differentiation of wild-type and three attenuated lapinized vaccine strains of classical swine fever virus by reverse transcription polymerase chain reaction Genetic differentiation of infected from vaccinated animals after implementation of an emergency vaccination strategy against classical swine fever in wild boar Evaluation of classical swine fever virus antibody detection assays with an emphasis on the differentiation of infected from vaccinated animals Antibody responses of pigs to defined E rns fragments after infection with classical swine fever virus Development of a classical swine fever subunit marker vaccine and companion diagnostic test Enzyme-linked immunosorbent assay using a virus type-specific peptide based on a subdomain of envelope protein Erns for serologic diagnosis of pestivirus infections in swine Laboratory diagnosis, epizootiology, and efficacy of marker vaccines in classical swine fever: A review Evaluation of an Erns-based enzyme-linked immunosorbent assay to distinguish Classical swine fever virus-infected pigs from pigs vaccinated with CP7_E2alf The double-antigen ELISA concept for early detection of E rns -specific classical swine fever virus antibodies and application as an accompanying test for differentiation of infected from marker vaccinated animals Differentiation of classical swine fever virus infection from CP7_E2alf marker vaccination by a multiplex microsphere immunoassay Discrimination within epitope specific antibody populations against classical swine fever virus is a new means of differentiating infection from vaccination Enhanced expression of the Erns protein of classical swine fever virus in yeast and its application in an indirect enzyme-linked immunosorbent assay for antibody differentiation of infected from vaccinated animals Bossis, I.


id: cord-002945-29nj4f05
author: Ambrose, Rebecca K.
title: In Vivo Characterisation of Five Strains of Bovine Viral Diarrhoea Virus 1 (Subgenotype 1c)
date: 2018-01-19
extension: .txt
mime: text/plain
words: 6608
sentence: 255
flesch: 47
cache: cache/cord-002945-29nj4f05.txt
txt: txt/cord-002945-29nj4f05.txt
summary:
  Predominant BVDV subtype in calves with respiratory disease Eradication of bovine viral diarrhea virus in Germany-diversity of subtypes and detection of live-vaccine viruses Bovine viral diarrhea virus: Global status Genetic and antigenic characterization of bovine viral diarrhea viruses isolated from cattle in Hokkaido Genomic and serological diversity of bovine viral diarrhea virus in Japan Pathogenicity of an Indian isolate of bovine viral diarrhea virus 1b in experimentally infected calves Virulent properties of russian bovine viral diarrhea virus strains in experimentally infected calves Kinetics of single and dual infection of calves with an Asian atypical bovine pestivirus and a highly virulent strain of bovine viral diarrhoea virus 1 Impact of variation in acute virulence of BVDV1 strains on design of better vaccine efficacy challenge models A bovine viral diarrhea virus type 1a strain in China: Isolation, identification, and experimental infection in calves Epidemiological features and economical importance of bovine virus diarrhoea virus (BVDV) infections Lack of virus transmission from bovine viral diarrhoea virus infected calves to susceptible peers Failure to spread bovine virus diarrhoea virus infection from primarily infected calves despite concurrent infection with bovine coronavirus Infectivity of pestivirus following persistence of acute infection Virulence comparison and quantification of horizontal bovine viral diarrhoea virus transmission following experimental infection in calves Distinction between persistent and transient infection in a bovine viral diarrhoea (bvd) control programme: Appropriate interpretation of real-time RT-PCR and antigen-ELISA test results Effects of exposure to bovine viral diarrhoea virus 1 on risk of bovine respiratory disease in Australian feedlot cattle The risk of transmission from sheep experimentally infected with bvdv-1c during the acute phase to bvdv naïve sheep Viral dose and immunosuppression modulate the progression of acute bvdv-1 infection in calves: Evidence of long term persistence after intra-nasal infection Practical significance of heterogeneity among BVDV strains: Impact of biotype and genotype on U.S. control programs Bovine viral diarrhoea virus (BVDV) subgenotypes in diagnostic laboratory accessions: Distribution of BVDV1a, 1b, and 2a subgenotypes Characteristics in the epidemiology of bovine viral diarrhea virus (BVDV) of relevance to control Level and duration of serum antibodies in cattle infected experimentally and naturally with bovine virus diarrhoea virus Real-time polymerase chain reaction as a rapid and efficient alternative to estimation of picornavirus titers by tissue culture infectious dose 50% or plaque forming units Quantitative PCR: A quality control assay for estimation of viable virus content in live attenuated goat pox vaccine Quantification system for the viral dynamics of a highly pathogenic simian/human immunodeficiency virus based on an in vitro experiment and a mathematical model Development and validation of a Q-PCR based TCID(50) method for human herpesvirus 6 Studies of the pathogenesis of bovine pestivirus-induced ovarian dysfunction in superovulated dairy cattle Early reproductive loss due to bovine pestivirus infection Increased reproductive losses in cattle infected with bovine pestivirus around the time of insemination A field investigation of the effects of bovine viral diarrhea virus infection around the time of insemination on the reproductive performance of cattle A single amino acid is critical for the expression of B-cell epitopes on the helicase domain of the pestivirus NS3 protein A Manual for the Primary Animal Health Care Worker; Food and Agriculture Organization (FAO Multiplex real-time RT-PCR detection of three viruses associated with the bovine respiratory disease complex Overall, the concentration of platelets in infected animals were reduced for most BVDV-1c strains on Day 7 and/or Day 14 post infection compared to Day 0.


id: cord-296419-j5rlgbl8
author: Powell, Joshua D.
title: Influenza-Omics and the Host Response: Recent Advances and Future Prospects
date: 2017-06-10
extension: .txt
mime: text/plain
words: 6228
sentence: 218
flesch: 32
cache: cache/cord-296419-j5rlgbl8.txt
txt: txt/cord-296419-j5rlgbl8.txt
summary:
  The landscape of viral proteomics and its potential to impact human health A comprehensive collection of systems biology data characterizing the host response to viral infection Influenza research database: An integrated bioinformatics resource for influenza virus research Mining tens of millions of expression profiles-database and tools update A bridge between the gene expression omnibus (geo) and bioconductor Pandemic influenza a H1N1 in swine and other animals Review of influenza a virus in swine worldwide: A call for increased surveillance and research History of swine influenza pandemic H1N1 influenza virus causes disease and upregulation of genes related to inflammatory and immune responses, cell death, and lipid metabolism in pigs 2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models Investigation of pathogenesis of H1N1 influenza virus and swine Streptococcus suis serotype 2 co-infection in pigs by microarray analysis Transcription analysis on response of swine lung to H1N1 swine influenza virus Transcriptomic and epigenetic profiling of the lung of influenza-infected pigs: A comparison of different birth weight and susceptibility groups Analysis of cellular proteome alterations in porcine alveolar macrophage cells infected with 2009 (H1N1) and classical swine H1N1 influenza viruses Epidemiology, evolution, and recent outbreaks of avian influenza virus in China Integrated analysis of microrna expression and mrna transcriptome in lungs of avian influenza virus infected broilers Genome wide host gene expression analysis in chicken lungs infected with avian influenza viruses Identification of host genes linked with the survivability of chickens infected with recombinant viruses possessing H5N1 surface antigens from a highly pathogenic avian influenza virus A comparative analysis of host responses to avian influenza infection in ducks and chickens highlights a role for the interferon-induced transmembrane proteins in viral resistance Comparative proteome analysis of tracheal tissues in response to infectious bronchitis coronavirus, newcastle disease virus, and avian influenza virus H9 subtype virus infection Proteomics analysis of differential expression of chicken brain tissue proteins in response to the neurovirulent H5N1 avian influenza virus infection Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza a virus receptors Animal models for influenza virus transmission studies: A historical perspective Integrated omics analysis of pathogenic host responses during pandemic H1N1 influenza virus infection: The crucial role of lipid metabolism Sequencing, annotation, and characterization of the influenza ferret infectome Host gene expression signatures discriminate between ferrets infected with genetically similar H1N1 strains De-novo transcriptome sequencing of a normalized cdna pool from influenza infected ferrets The use of nonhuman primates in research on seasonal, pandemic and avian influenza Integrated molecular signature of disease: Analysis of influenza virus-infected macaques through functional genomics and proteomics Macaque proteome response to highly pathogenic avian influenza and 1918 reassortant influenza virus infections Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes Increased viral loads and exacerbated innate host responses in aged macaques infected with the 2009 pandemic H1N1 influenza a virus Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems Influenza a virus challenge models in cynomolgus macaques using the authentic inhaled aerosol and intra-nasal routes of infection The 1918 influenza virus PB2 protein enhances virulence through the disruption of inflammatory and wnt-mediated signaling in mice Lethal dissemination of H5N1 influenza virus is associated with dysregulation of inflammation and lipoxin signaling in a mouse model of infection Insights into the increasing virulence of the swine-origin pandemic H1N1/2009 influenza virus Dynamic changes in host gene expression associated with H5N8 avian influenza virus infection in mice H7N9 and other pathogenic avian influenza viruses elicit a three-pronged transcriptomic signature that is reminiscent of 1918 influenza virus and is associated with lethal outcome in mice Gene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza a infection Rnaseq expression analysis of resistant and susceptible mice after influenza a virus infection identifies novel genes associated with virus replication and important for host resistance to infection Informatics resources for the collaborative cross and related mouse populations Modeling host genetic regulation of influenza pathogenesis in the collaborative cross Itraq-based quantitative proteomics reveals important host factors involved in the high pathogenicity of the h5n1 avian influenza virus in mice Ion-current-based temporal proteomic profiling of influenza-a-virus-infected mouse lungs revealed underlying mechanisms of altered integrity of the lung microvascular barrier


id: cord-297469-26d8o1xk
author: Choi, Won Hyung
date: 2019-05-09
extension: .txt
mime: text/plain
words: 7005
sentence: 194
flesch: 33
cache: cache/cord-297469-26d8o1xk.txt
txt: txt/cord-297469-26d8o1xk.txt
title:
  The Mechanism of Action of Ursolic Acid as a Potential Anti-Toxoplasmosis Agent, and Its Immunomodulatory Effects

summary:
  These changes demonstrate that UA promotes the production and the expression of IL-10 and IL-12 by consistently stimulating the immune cells as well as inhibit the expressions of IL-1β and IL-6 induced by T. gondii infection. These results indicate that UA not only effectively induces the production of cytokines between the immune cells by increasing the expression of IL-10 and IL-12 in macrophage and B cells after T. gondii infection, but also suppresses or strongly reduces the expression of the inflammatory cytokines from the immune cells.


id: cord-013315-plptulfb
author: Tilocca, Bruno
date: 2020-08-27
extension: .txt
mime: text/plain
words: 6837
sentence: 301
flesch: 36
cache: cache/cord-013315-plptulfb.txt
txt: txt/cord-013315-plptulfb.txt
title:
  Immunoinformatic-Based Prediction of Candidate Epitopes for the Diagnosis and Control of Paratuberculosis (Johne’s Disease)

summary:
  The list of epitope sequences was further analyzed through the Basic Local Alignment Search Tool for protein sequences (pBLAST) The list of epitope sequences was further analyzed through the Basic Local Alignment Search Tool for protein sequences (pBLAST)


id: cord-342921-lpn6cqz3
author: Leguia, Mariana
title: Full Genomic Characterization of a Saffold Virus Isolated in Peru
date: 2015-11-20
extension: .txt
mime: text/plain
words: 2159
sentence: 88
flesch: 42
cache: cache/cord-342921-lpn6cqz3.txt
txt: txt/cord-342921-lpn6cqz3.txt
summary:
  A number of available SAFV sequences were downloaded from GenBank to serve as references (Table 1) . Despite their extensive distribution, only a handful of SAFV genomic sequences from the Americas have been described [7] [8] [9] .


id: cord-322317-wsagoy52
author: Stranieri, Angelica
date: 2020-10-18
extension: .txt
mime: text/plain
words: 7553
sentence: 267
flesch: 42
cache: cache/cord-322317-wsagoy52.txt
txt: txt/cord-322317-wsagoy52.txt
title:
  Concordance between Histology, Immunohistochemistry, and RT-PCR in the Diagnosis of Feline Infectious Peritonitis

summary:
  Histological examination was performed on 93 tissue samples obtained from FIP cats and 83 obtained from non FIP cats. On the other hand, non FIP cats are less likely to shed the virus in the feces compared with FIP cats [17] .


id: cord-328395-2cakgmsj
author: Oxford, Alexandra E.
title: Endothelial Cell Contributions to COVID-19
date: 2020-09-25
extension: .txt
mime: text/plain
words: 6719
sentence: 289
flesch: 35
cache: cache/cord-328395-2cakgmsj.txt
txt: txt/cord-328395-2cakgmsj.txt
summary:
  In addition, endothelial cell infection promotes the formation of thrombus associated with an elevated neutrophil count This review will focus on the concept of endothelial cell infection and dysfunction as an active driver of COVID-19, which begins as a respiratory illness, with vascular pathology contributing significantly to the most negative patient outcomes.


id: cord-271648-m2c5bvuj
author: Ashour, Hossam M.
date: 2020-03-04
extension: .txt
mime: text/plain
words: 7550
sentence: 344
flesch: 53
cache: cache/cord-271648-m2c5bvuj.txt
txt: txt/cord-271648-m2c5bvuj.txt
title:
  Insights into the Recent 2019 Novel Coronavirus (SARS-CoV-2) in Light of Past Human Coronavirus Outbreaks

summary:
  Implications for virus origins and receptor binding Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2 Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis Elastase-mediated activation of the severe acute respiratory syndrome coronavirus spike protein at discrete sites within the S2 domain Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade Protease-mediated enhancement of severe acute respiratory syndrome coronavirus infection Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein Generation and characterization of human monoclonal neutralizing antibodies with distinct binding and sequence features against SARS coronavirus using XenoMouse Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution Identification of an antigenic determinant on the S2 domain of the severe acute respiratory syndrome coronavirus spike glycoprotein capable of inducing neutralizing antibodies Human monoclonal antibodies against highly conserved HR1 and HR2 domains of the SARS-CoV spike protein are more broadly neutralizing Fully human monoclonal antibody directed to proteolytic cleavage site in severe acute respiratory syndrome (SARS) That sort of adaptation required a set of amino acid changes in the RBD of S protein of SARS viruses that were circulating in bats [65] .


id: cord-292031-weiwksh6
author: Ramírez-Castillo, Flor Yazmín
title: Waterborne Pathogens: Detection Methods and Challenges
date: 2015-05-21
extension: .txt
mime: text/plain
words: 7362
sentence: 259
flesch: 27
cache: cache/cord-292031-weiwksh6.txt
txt: txt/cord-292031-weiwksh6.txt
summary:
  Even though culture dependent methods are extensively used for pathogens detection in water, these methods are limited by their low sensitivity and the excessive time needed to obtain reliable results. The Microbiology of the Water Distribution System A Report on an American Academy of Microbiology Colloquium Recommended advanced techniques for waterborne pathogen detection in developing countries Dei-Cas, E. Microbial agents associated with waterborne diseases Global Water, Sanitation, and Hygiene (WASH) Progress on Sanitation and Drinking-Water Contamination of water resources by pathogenic bacteria Millennium Development Goals: Progress towards the Health-Related Millennium Development Goals Waterborne outbreaks reported in the United States Causes of outbreaks associated with drinking water in the United States from A fatal waterborne disease epidemic in Walkerton, Ontario: Comparison with other waterborne outbreaks in the developed world Surveillance for waterborne disease outbreaks associated with drinking water and other nonrecreational water-United States Epidemiology of cholera in the Philippines The 2010 cholera outbreak in Haiti: How science solved a controversy Lessons learned during public health response to cholera epidemic in Haiti and the Dominican Republic Shiga toxin-producing Escherichia coli O104:H4: A new challenge for microbiology Annual Epidemiological Report Food-and Waterborne Diseases and Zoonoses Self-reported diarrhea in a control group: A strong association with reporting of low-pressure events in tap water Global Drinking Water Management and Conservation Optimal Decision-Making Surveillance for waterborne-disease outbreaks associated with drinking water--United States Emerging waterborne pathogens: Can we kill them all? Where do emerging pathogens come from?


id: cord-331022-tek4u751
author: Sinderewicz, Emilia
title: Immune Response to COVID-19: Can We Benefit from the SARS-CoV and MERS-CoV Pandemic Experience?
date: 2020-09-09
extension: .txt
mime: text/plain
words: 8489
sentence: 326
flesch: 40
cache: cache/cord-331022-tek4u751.txt
txt: txt/cord-331022-tek4u751.txt
summary:
  A comparison of the content of proinflammatory Th1 and Th2 cytokines in the serum of SARS patients with healthy controls documented a significantly greater concentration of TNF-α, IL-6, IL-8, IL-10, and IL-12 in the early stage of the SARS-CoV infection [32, 40] . It has been documented that increased IL-6 concentration in plasma of SARS patients was significantly increased in severe cases, but not in convalescent or control subjects, suggesting a positive correlation between serum IL-6 level and disease severity [61] .


id: cord-302161-ytr7ds8i
author: Lutz, Mirjam
date: 2020-07-24
extension: .txt
mime: text/plain
words: 9917
sentence: 365
flesch: 50
cache: cache/cord-302161-ytr7ds8i.txt
txt: txt/cord-302161-ytr7ds8i.txt
title:
  FCoV Viral Sequences of Systemically Infected Healthy Cats Lack Gene Mutations Previously Linked to the Development of FIP

summary:
  To track viral sequence mutations in organs of healthy FCoV carrier cats, we investigated FCoV sequences detected in the colon, liver, and thymus, as well as feces of seven experimentally FCoV infected cats. The overall comparison of FCoV gene sequences from the different cats euthanized at different time points after infection did not reveal any significant differences (Table 3) .


id: cord-355788-6hteott0
author: Shirvani, Edris
title: Newcastle Disease Virus as a Vaccine Vector for SARS-CoV-2
date: 2020-07-29
extension: .txt
mime: text/plain
words: 4090
sentence: 190
flesch: 47
cache: cache/cord-355788-6hteott0.txt
txt: txt/cord-355788-6hteott0.txt
summary:
  A preliminary report Attenuated veterinary virus vaccine for the treatment of cancer Phase I trial of intravenous administration of PV701, an oncolytic virus, in patients with advanced solid cancers Newcastle disease virus: A promising vector for viral therapy, immune therapy, and gene therapy of cancer Recovery of a virulent strain of Newcastle disease virus from cloned cDNA: Expression of a foreign gene results in growth retardation and attenuation High-level expression of a foreign gene from the 31 proximal first locus of a recombinant Newcastle disease virus Recombinant Newcastle disease virus as a vaccine vector Recombinant Newcastle disease virus as a viral vector: Effect of genomic location of foreign gene on gene expression and virus replication Optimization of human immunodeficiency virus Gag expression by Newcastle disease virus vectors for the induction of potent immune responses P and M gene junction is the optimal insertion site in Newcastle disease virus vaccine vector for foreign gene expression This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license Author Contributions: S.K.S. and E.S.; writing. NDV vector vaccines have shown promising results against SARS-CoV and IBV


id: cord-323380-hm9wd817
author: Helmy, Yosra A.
date: 2017-07-21
extension: .txt
mime: text/plain
words: 9801
sentence: 479
flesch: 42
cache: cache/cord-323380-hm9wd817.txt
txt: txt/cord-323380-hm9wd817.txt
title:
  A Comprehensive Review of Common Bacterial, Parasitic and Viral Zoonoses at the Human-Animal Interface in Egypt

summary:
  The highest prevalences of S. haematobium were detected in lower Egypt [106, 109] , while the highest prevelance of S. mansoni was detected around central Egypt [102, 118, 119] . Q fever may be enzootic in cattle in northern Egypt


id: cord-309381-cb80ntxs
author: Nogales, Aitor
title: Host Single Nucleotide Polymorphisms Modulating Influenza A Virus Disease in Humans
date: 2019-09-30
extension: .txt
mime: text/plain
words: 10240
sentence: 451
flesch: 40
cache: cache/cord-309381-cb80ntxs.txt
txt: txt/cord-309381-cb80ntxs.txt
summary:
  Just as an example mentioned below, IFITM3 is an ISG playing antiviral roles against influenza virus infection and other viruses [59] . B influenza viruses: Basis for the WHO recommendation on the composition of influenza vaccines for use in the 2009-2010 northern hemisphere season Prevention and Control of Seasonal Influenza with Vaccines The annual impact of seasonal influenza in the US: Measuring disease burden and costs The continual threat of influenza virus infections at the human-animal interface: What is new from a one health perspective?


id: cord-319799-h9kot3og
author: Schäfer, Alexandra
title: Epigenetic Landscape during Coronavirus Infection
date: 2017-02-15
extension: .txt
mime: text/plain
words: 10092
sentence: 388
flesch: 29
cache: cache/cord-319799-h9kot3og.txt
txt: txt/cord-319799-h9kot3og.txt
summary:
  It is becoming well established that many DNA viruses, and to some lesser extent RNA viruses, have evolved functions that antagonize the regulatory machine of the host epigenome, leading to regulated changes in host gene expression that lead to a favorable environment for virus replication and spread [36] . Over the last decade, research efforts have revealed a dynamic range of epigenetic factors that shape and regulate chromatin status, leading to changes in host gene expression patterns, and therefore to alterations in phenotypes.


id: cord-013280-kczj24se
author: Yang, Bo
title: Molecular Mechanisms of Immune Escape for Foot-and-Mouth Disease Virus
date: 2020-09-04
extension: .txt
mime: text/plain
words: 11333
sentence: 469
flesch: 41
cache: cache/cord-013280-kczj24se.txt
txt: txt/cord-013280-kczj24se.txt
summary:
  Recently, new mechanisms and functions of FMDV proteins inhibiting innate immunity have been discovered. This review summrized the molecular mechanisms of immune evasion caused by FMDV proteins.


id: cord-331020-lyxje82u
author: M. Najimudeen, Shahnas
date: 2020-09-24
extension: .txt
mime: text/plain
words: 6968
sentence: 269
flesch: 31
cache: cache/cord-331020-lyxje82u.txt
txt: txt/cord-331020-lyxje82u.txt
title:
  Infectious Bronchitis Coronavirus Infection in Chickens: Multiple System Disease with Immune Suppression

summary:
  Viruses Antigenic and Pathogenic Characteristics of QX-Type Avian Infectious Bronchitis Virus Strains Isolated in Southwestern China Molecular characterization of pathogenic 4/91-like and QX-like infectious bronchitis virus infecting commercial poultry farms in Indonesia Recombinant infectious bronchitis coronavirus Beaudette with the spike protein gene of the pathogenic M41 strain remains attenuated but induces protective immunity Development and characterization of a recombinant infectious bronchitis virus expressing the ectodomain region of S1 gene of H120 strain Heparan Sulfate Is a Selective Attachment Factor for the Avian Coronavirus Infectious Bronchitis Virus Beaudette Sialic acid is a receptor determinant for infection of cells by avian Infectious bronchitis virus Binding of avian coronavirus spike proteins to host factors reflects virus tropism and pathogenicity Glycosylation of the viral attachment protein of avian coronavirus is essential for host cell and receptor binding The pathogenesis of nephritis in chickens induced by infectious bronchitis virus Pathogenesis of Oviduct Lesions in Immature Chickens Following Exposure to Infectious Bronchitis Virus at One Day Old A 'new' strain of infectious bronchitis virus infecting domestic fowl in Great Britain Immunopathogenesis of infection in SPF chicks and commercial broiler chickens of a variant infectious bronchitis virus of economic importance Infectious bronchitis Nephropathogenicity of infectious bronchitis virus The etiology of uraemia of chickens Infectious avian nephrosis (uraemia) in Australia Isolation of avian infectious bronchitis virus from experimentally infected chickens In vitro characterization and pathogenesis of Egypt/Beni-Suef/01; a novel genotype of infectious bronchitis virus Establishment of Persistent Avian Infectious Bronchitis Virus Infection in Antibody-Free and Antibody-Positive Chickens Avian infectious bronchitis: Viral persistence in the harderian gland and histological changes after eyedrop vaccination Pathogenicity of a TW-Like Strain of Infectious Bronchitis Virus and Evaluation of the Protection Induced against It by a QX-Like Strain Comparison of the susceptibility to avian infectious bronchitis virus infection of two inbred lines of white leghorn chickens Electron microscope observations on the entry of avian infectious bronchitis virus into susceptible cells Histopathology and immunohistochemistry of renal lesions due to infectious bronchitis virus in chicks Detection of viral antigen following exposure of one-day-old chickens to the Holland 52 strain of infectious bronchitis virus Isolation of 4/91 Type of Infectious Bronchitis Virus as a New Variant in Japan and Efficacy of Vaccination Against 4/91 Type Field Isolate Productive replication of nephropathogenic infectious bronchitis virus in peripheral blood monocytic cells, a strategy for viral dissemination and kidney infection in chickens Tissue Tropism of Three Cloacal Isolates and Massachusetts Strain of Infectious Bronchitis Virus Pathogenesis and tissue distribution of avian infectious bronchitis virus isolate IRFIBV32 Experiences of vaccination against avian infectious bronchitis coronavirus The Effect of Infectious Bronchitis Virus on Chickens Infected with Mycoplasma gallisepticum Synergism between avian infectious bronchitis virus and Haemophilus gallinarum Effect of in ovo bursectomy on the course of an infectious bronchitis virus infection in line C White Leghorn chickens Cytotoxic T cells are critical in the control of infectious bronchitis virus in poultry Specific antibody secreting cells from chickens can be detected by three days and memory B cells by three weeks post-infection with the avian respiratory coronavirus Memory T cells protect chicks from acute infectious bronchitis virus infection Infectious Bronchitis Virus Immune Responses in the Harderian Gland upon Initial Vaccination Cellular, and Humoral Immune Responses Induced by Different Live Infectious Bronchitis Virus Vaccination Regimes and Protection Conferred against Infectious Bronchitis Virus Q1 Strain Disease of Poultry Infectious bronchitis Maternal antibody to infectious bronchitis virus: Its role in protection against infection and development of active immunity to vaccine Infectious bronchitis in laying hens: Interference with response to emulsion vaccine by attenuated live vaccine Studies with a bivalent infectious bronchitis killed virus vaccine Development and use of the H strain of avian infectious bronchitis virus from the Netherlands as a vaccine: A review Pathogenicity of a QX strain of infectious bronchitis virus in specific pathogen free and commercial broiler chickens, and evaluation of protection induced by a vaccination programme based on the Ma5 and 4/91 serotypes Characterization of a novel live attenuated infectious bronchitis virus vaccine candidate derived from a Korean nephropathogenic strain Safety and efficacy of an infectious bronchitis virus used for chicken embryo vaccination Infectious bronchitis Breadth of protection of the respiratory tract provided by different live-attenuated infectious bronchitis vaccines against challenge with infectious bronchitis viruses of heterologous serotypes Isolation and identification of four infectious bronchitis virus strains in China and analyses of their S1 glycoprotein gene Genetic Analysis of the S1 Gene of 4/91 Type Infectious Bronchitis Virus Isolated in Japan Transmissibility of Infectious Bronchitis Virus H120 Vaccine Strain among Broilers under Experimental Conditions Molecular epizootiology of infectious bronchitis virus in Sweden indicating the involvement of a vaccine strain Ion channel activity of influenza A virus M2 protein: Characterization of the amantadine block Genetic mutations in live infectious bronchitis vaccine viruses following single or dual in vitro infection of tracheal organ cultures Different evolutionary trajectories of vaccine-controlled and non-controlled avian infectious bronchitis viruses in commercial poultry Avian coronavirus infectious bronchitis attenuated live vaccines undergo selection of subpopulations and mutations following vaccination Hatchery Vaccination Against Poultry Viral Diseases: Potential Mechanisms and Limitations Genotyping of infectious bronchitis viruses identified in Canada between Vaccine efficacy against Ontario isolates of infectious bronchitis virus Using phylogenetic analysis to examine the changing strains of infectious bronchitis virus infections in Ontario over time Vaccination against infectious bronchitis virus: A continuous challenge Inactivated infectious bronchitis virus vaccine encapsulated in chitosan nanoparticles induces mucosal immune responses and effective protection against challenge Etiology and immunology of infectious bronchitis virus Comparison of the pathogenicity of QX-like, M41 and 793/B infectious bronchitis strains from different pathological conditions This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license The authors declare no conflict of interest.


id: cord-327000-oyg3oyx1
author: Li, Shasha
title: Porcine Epidemic Diarrhea Virus and the Host Innate Immune Response
date: 2020-05-11
extension: .txt
mime: text/plain
words: 11139
sentence: 482
flesch: 41
cache: cache/cord-327000-oyg3oyx1.txt
txt: txt/cord-327000-oyg3oyx1.txt
summary:
  These cap structures enhance the initiation of translation of viral proteins, protect viral mRNAs against cellular 5 -3 -exoribonuclease and limit the recognition of viral RNA by host innate system [120, 121] . Although several studies have been performed to understand the pathogenicity of PEDV, there remains limited information about the interaction between viral proteins and host cell factors during viral infection.


id: cord-351567-ifoe8x28
author: Rabi, Firas A.
title: SARS-CoV-2 and Coronavirus Disease 2019: What We Know So Far
date: 2020-03-20
extension: .txt
mime: text/plain
words: 5766
sentence: 241
flesch: 49
cache: cache/cord-351567-ifoe8x28.txt
txt: txt/cord-351567-ifoe8x28.txt
summary:
  Initial virological and clinical findings Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Controlled Trial of Ebola Virus Disease Therapeutics Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro First Case of 2019 Novel Coronavirus in the United States NIH Clinical Trial of Remdesivir to Treat COVID-19 Begins Gilead Sciences Initiates Two Phase 3 Studies of Investigational Antiviral Remdesivir for the Treatment of COVID-19 Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Protease inhibitors targeting coronavirus and filovirus entry Camostat Mesilate, Pancrelipase, and Rabeprazole Combination Therapy Improves Epigastric Pain in Early Chronic Pancreatitis and Functional Dyspepsia with Pancreatic Enzyme Abnormalities TACTIC Investigative Team a phase 1/2 trial to evaluate the pharmacokinetics, safety, and efficacy of NI-03 in patients with chronic pancreatitis: Study protocol for a randomized controlled trial on the assessment of camostat treatment in chronic pancreatitis (TACTIC) However, by that time, travelers had carried the virus to many countries, sparking memories of the previous coronavirus epidemics, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), and causing widespread media attention and panic.


id: cord-335774-15fhg8o9
author: Mull, Nathaniel
title: Ecology of Neglected Rodent-Borne American Orthohantaviruses
date: 2020-04-26
extension: .txt
mime: text/plain
words: 6842
sentence: 266
flesch: 33
cache: cache/cord-335774-15fhg8o9.txt
txt: txt/cord-335774-15fhg8o9.txt
summary:
  While studying such viruses is important, there are an untold number of other pathogens that persist among humans and wildlife that receive little to no attention [1] . Empirical data on the ecology of neglected American orthohantaviruses are crucial to understanding transmission and persistence of such viruses and threats to human health.


id: cord-334907-l4jjb93l
author: Ojeda, Nicolás
title: Interaction of the Amino-Terminal Domain of the ISAV Fusion Protein with a Cognate Cell Receptor
date: 2020-05-27
extension: .txt
mime: text/plain
words: 10708
sentence: 397
flesch: 43
cache: cache/cord-334907-l4jjb93l.txt
txt: txt/cord-334907-l4jjb93l.txt
summary:
  Both Phe residues are highly conserved amongst ISAV F sequences reported in GenBank, with only 4% of them showing a Phe183Leu change (data not shown), which correlates with the importance of their function, as proven by these results. HE and F fusion proteins were cloned between the Not I/Bam HI and Eco RI/Bam HI sites of the p3xFLAG-CMV14 vector.


id: cord-255339-oudj079q
author: Al-Tayib, Omar A.
date: 2019-02-22
extension: .txt
mime: text/plain
words: 15858
sentence: 615
flesch: 42
cache: cache/cord-255339-oudj079q.txt
txt: txt/cord-255339-oudj079q.txt
title:
  An Overview of the Most Significant Zoonotic Viral Pathogens Transmitted from Animal to Human in Saudi Arabia

summary:
  Borne Zoonotic Dis Update on the global spread of dengue Virologic and serologic surveillance for dengue fever in Jeddah, Saudi Arabia, 1994-1999 Clinical profile and outcome of hospitalized patients during first outbreak of dengue in Makkah, Saudi Arabia Department of Communicable Diseases, Ministry of Health (MOH) Saudi Arabia Ministry of Health: Riyadh, Saudi Arabia Phylogeny of dengue viruses circulating in Jeddah Reconstructing historical changes in the force of infection of dengue fever in Singapore: Implications for surveillance and control Dengue fever Clinical features of 567 consecutive patients admitted to a tertiary care center in Saudi Arabia Characteristics of dengue fever in a large public hospital Factors associated with the spread of dengue fever in Jeddah Governorate, Saudi Arabia. According to a March 3 statement, another patient, a 74-year-old man from Najran located in southern Saudi Arabia, was reported.


id: cord-350423-yaeduwvb
author: James, Claire D.
title: Viral Interactions with PDZ Domain-Containing Proteins—An Oncogenic Trait?
date: 2016-01-18
extension: .txt
mime: text/plain
words: 10646
sentence: 330
flesch: 31
cache: cache/cord-350423-yaeduwvb.txt
txt: txt/cord-350423-yaeduwvb.txt
summary:
  Perhaps not surprisingly considering the wide remit of PDZ protein functions, deregulation of a number of PDZ proteins has been linked to tumourigenesis [2] . What is striking is that the diverse viruses target a common subset of PDZ proteins that are intimately involved in controlling cell polarity and the structure and function of intercellular junctions, including tight junctions.


id: cord-314825-fzba05wn
author: Chauhan, Ravendra P.
date: 2020-05-08
extension: .txt
mime: text/plain
words: 22381
sentence: 1067
flesch: 51
cache: cache/cord-314825-fzba05wn.txt
txt: txt/cord-314825-fzba05wn.txt
title:
  A Systematic Review Analyzing the Prevalence and Circulation of Influenza Viruses in Swine Population Worldwide

summary:
  H9N2 seroprevalence among pig population and pig farm staff in Shandong Serological evidence of hepatitis E virus and influenza A virus infection in farmed wild boars in China Identification of a potential novel type of influenza virus in Bovine in China Emergence of avian H1N1 influenza viruses in pigs in China Receptor specificity in human, avian, and equine H2 and H3 influenza virus isolates H9N2 influenza A viruses from poultry in Asia have human virus-like receptor specificity First report of seroprevalence of swine influenza A virus in Tibetan pigs in Tibet Seroprevalence and associated risk factors of important pig viral diseases in Bhutan Serologic evidence of human influenza virus infections in swine populations Influenza A Virus in Backyard Pigs and Poultry in Rural Cambodia An outbreak of influenza in the swine with Hong Kong influenza virus (author's transl) Antigenic and genetic analysis of A/Hong Kong (H3N2) influenza viruses isolated from swine and man The follow-up study of swine and Hong Kong influenza virus infection among Japanese hogs Isolation of a recombinant influenza virus (Hsw 1 N2) from swine in Japan Sero-epizootiological study on swine influenza in a prefecture of Japan Further isolation of a recombinant virus (H1N2, formerly Hsw1N2) from a pig in Japan in 1980 The possible origin H1N1 (Hsw1N1) virus in the swine population of Japan and antigenic analysis of the isolates Prevalence of antibody to influenza C virus among pigs in Hyogo Prefecture Distribution of the antibody to influenza C virus in dogs and pigs in Yamagata Prefecture Continued circulation of reassortant H1N2 influenza viruses in pigs in Japan Novel reassortant influenza A(H1N2) virus derived from A(H1N1)pdm09 virus isolated from swine Occurrence of a pig respiratory disease associated with swine influenza A (H1N2) virus in Tochigi Prefecture Prevalence of antibodies to type A influenza viruses in swine sera 1990-1994 Antigenic and genetic characteristics of H1N1 human influenza virus isolated from pigs in Japan Genomic reassortants of pandemic A (H1N1) 2009 virus and endemic porcine H1 and H3 viruses in swine in Japan Influenza A virus infection Serological survey of influenza A virus infection in Japanese wild boars (Sus scrofa leucomystax) Isolation of H3N2 swine influenza virus in South Korea Genetic characterization of H7N2 influenza virus isolated from pigs Detection and isolation of H1N1 influenza virus from pigs in Korea Localization of swine influenza virus in naturally infected pigs First outbreak of respiratory disease associated with swine influenza H1N2 virus in pigs in Korea Serologic surveillance of swine H1 and H3 and avian H5 and H9 influenza A virus infections in swine population in Korea Genetic and antigenic characterization of swine H1N2 influenza viruses isolated from Korean pigs Isolation of influenza A(H3N2)v virus from pigs and characterization of its biological properties in pigs and mice Isolation and genetic characterization of H5N2 influenza viruses from pigs in Korea Isolation and phylogenetic analysis of H1N1 swine influenza virus isolated in Korea Phylogenetic analysis of swine influenza viruses recently isolated in Korea Isolation and characterization of novel H3N1 swine influenza viruses from pigs with respiratory diseases in Korea Evidence of human-to-swine transmission of the pandemic (H1N1) 2009 influenza virus in South Korea Identification of reassortant pandemic H1N1 influenza virus in Korean pigs Phylogenetic analysis of a swine influenza A(H3N2) virus isolated in Korea in 2012 Serological evidence for influenza virus infection in Korean wild boars Complete Genome Sequence of H1N1 Swine Influenza Virus from Pigs in the Republic of Korea in 2016 Isolation and serological characterization of influenza A virus from a pig in Thailand The first isolation of swine H1N1 influenza viruses from pigs in Thailand Genetic diversity of swine influenza viruses isolated from pigs during 2000 to 2005 in Thailand. Inter-species transmission of equine influenza virus H3N8 from horse to swine in China expanded the genetic diversity of swine influenza viruses.


id: cord-337259-b12fp75d
author: Segura, Mariela
date: 2020-05-14
extension: .txt
mime: text/plain
words: 20956
sentence: 854
flesch: 39
cache: cache/cord-337259-b12fp75d.txt
txt: txt/cord-337259-b12fp75d.txt
title:
  Update on Streptococcus suis Research and Prevention in the Era of Antimicrobial Restriction: 4th International Workshop on S. suis †

summary:
  Facing the new regulations in preventive use of antimicrobials in livestock and lack of effective vaccines, control of S. suis infections is worrisome. To date, four outbreaks of S. suis infections in humans have been recorded in that country, with case fatality rates varying from 6.5% to 16.1%.


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