item: #1 of 672 id: cord-000006-104sqoxz author: Bray, Daniel P. title: Composition and Function of Haemolymphatic Tissues in the European Common Shrew date: 2008-10-15 words: 5701 flesch: 42 summary: All ages seemed able to mount systemic, specific immune responses, but adult shrews showed some signs of lymphatic tissue exhaustion: lymphatic follicles in adults (n = 21) were both smaller than those in sub-adults (n = 18; Wald = 11.1, p<0.05) and exhibited greater levels of depletion (Wald = 13.3, p<0.05). This may allow older animals to react effectively to previously encountered parasites, but infection by novel agents, and eventual depletion of plasma cell reserves, could both still be factors in the near-synchronous mortality of adult shrews observed shortly after breeding. keywords: adult; animals; araneus; aselli; cells; follicles; pancreas; plasma; shrews; sub cache: cord-000006-104sqoxz.txt plain text: cord-000006-104sqoxz.txt item: #2 of 672 id: cord-000008-3dgjv0x1 author: Vali, Bahareh title: HIV-Specific T-Cells Accumulate in the Liver in HCV/HIV Co-Infection date: 2008-10-20 words: 5272 flesch: 42 summary: Effect of human immunodeficiency virus on hepatitis C virus infection among injecting drug users Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection Retrospective analysis of the impact of HIV infection and alcohol use on chronic hepatitis C in a large cohort of drug users Influence of human immunodeficiency virus infection on the course of hepatitis C virus infection: a meta-analysis Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis The role of tumor necrosis factor-alpha in liver toxicity, inflammation, and fibrosis induced by carbon tetrachloride Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection HIV longterm non-progressors maintain brisk CD8 T cell responses to other viral antigens CD8+ cell responses to hepatitis C virus (HCV) in the liver of persons with HCV-HIV coinfection versus HCV monoinfection Comparison of HCV-specific intrahepatic CD4+ T cells in HIV/HCV versus HCV Human immunodeficiency virus type 1-hepatitis C virus coinfection: intraindividual comparison of cellular immune responses against two persistent viruses Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection HIV-specific CD8+ lymphocytes in semen are not associated with reduced HIV shedding Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection The liver as a site of T-cell apoptosis: graveyard, or killing field? To determine the presence of intra-hepatic viral specific T-cell responses, liver isolated cells were stimulated with HCV and HIV peptide pools. keywords: cd8; cells; hcv; hiv; liver; responses cache: cord-000008-3dgjv0x1.txt plain text: cord-000008-3dgjv0x1.txt item: #3 of 672 id: cord-000013-pr9i9swk author: Croyle, Maria A. title: Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves the Immune Response in Mice date: 2008-10-29 words: 6535 flesch: 32 summary: In the presence of pre-existing immunity, only mice vaccinated I.N. survived. Pre-existing immunity did not compromise the frequency of IFN-γ+ CD8+ T cells (3.9±1% naïve vs. 3.6±1% pre-existing immunity, PEI) nor anti-Ebola neutralizing antibody (NAB, 40±10 reciprocal dilution, both groups). keywords: ad5; adenovirus; animals; antibody; cells; ebola; immune; immunity; mice; recombinant; response; vaccination; vaccine cache: cord-000013-pr9i9swk.txt plain text: cord-000013-pr9i9swk.txt item: #4 of 672 id: cord-000050-tfcerilc author: Rao, Srinivas title: Multivalent HA DNA Vaccination Protects against Highly Pathogenic H5N1 Avian Influenza Infection in Chickens and Mice date: 2008-06-18 words: 5614 flesch: 39 summary: A DNA prime-Mycobacterium bovis BCG boost vaccination strategy for cattle induces protection against bovine tuberculosis Immune response in mice and cattle after immunization with a Boophilus microplus DNA vaccine containing bm86 gene Immunization of pigs to prevent disease in humans: construction and protective efficacy of a Salmonella enterica serovar Typhimurium live negative-marker vaccine Humoral response to West Nile virus vaccination in alpacas and llamas Preliminary results of an anticircumsporozoite DNA vaccine trial for protection against avian malaria in captive African black-footed penguins (Spheniscus demersus) Recombinant influenza A virus vaccines for the pathogenic human A/Hong Kong/97 (H5N1) viruses Immunization of turkeys with a DNA vaccine expressing either the F or N gene of avian metapneumovirus Protection of turkeys against Chlamydophila psittaci challenge by DNA and rMOMP vaccination and evaluation of the immunomodulating effect of 1 alpha DNA vaccination in the avian Cross-protection among lethal H5N2 influenza viruses induced by DNA vaccine to the hemagglutinin Enhanced protective efficacy of H5 subtype avian influenza DNA vaccine with codon optimized HA gene in a pCAGGS plasmid vector Characterization of H5N1 influenza viruses that continue to circulate in geese in southeastern Control and prevention of avian influenza in an evolving scenario Genesis of pandemic influenza Containing pandemic influenza at the source The next influenza pandemic: can it be predicted viruses and vaccines Scientific barriers to developing vaccines against avian influenza viruses Overview of avian influenza DIVA test strategies Emergence and predominance of an H5N1 influenza variant in China A human T-cell leukemia virus type 1 regulatory element enhances the immunogenicity of human immunodeficiency virus type 1 DNA vaccines in mice and nonhuman primates Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity Protective immunity to lethal challenge of the 1918 pandemic influenza virus by vaccination Crossprotectiveness and immunogenicity of influenza A/Duck/Singapore/3/97(H5) vaccines against infection with A/Vietnam/1203/04(H5N1) virus in ferrets Vesicular stomatitis virus vectors expressing avian influenza H5 HA induce cross-neutralizing antibodies and long-term protection Efficacy of the AGRO-JET MIT-II NEEDLE-LESS JET INJECTOR for Iron Dextran Administration in Piglets Molecular determinants within the surface proteins involved in the pathogenicity of H5N1 influenza viruses in chickens Are we ready for pandemic influenza? For the two 5 plasmid combination groups pCMV/R 8kB-HA Biological features of genetic immunization DNA vaccines DNA vaccines: immunology, application, and optimization Strategies for inducing protection against avian influenza A virus subtypes with DNA vaccines A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice Immunotargeting with CD154 (CD40 ligand) enhances DNA vaccine responses in ducks Development and application of reference antisera against 15 hemagglutinin subtypes of influenza virus by DNA vaccination of chickens Effects of DDA, CpG-ODN, and plasmid-encoded chicken IFN-gamma on protective immunity by a DNA vaccine against IBDV in chickens Principles for vaccine protection in chickens and domestic waterfowl against avian influenza: emphasis on Asian H5N1 high pathogenicity avian influenza Association of serologic and protective responses of avian influenza vaccines in chickens Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques Route and method of delivery of DNA vaccine influence immune responses in mice and non-human primates Needle-free injection of DNA vaccines: a brief overview and methodology keywords: animals; avian; chickens; dna; h5n1; immunization; influenza; mice; protection; vaccine; virus; viruses cache: cord-000050-tfcerilc.txt plain text: cord-000050-tfcerilc.txt item: #5 of 672 id: cord-000063-tex6bgab author: Sui, Hong-Yan title: Small Interfering RNA Targeting M2 Gene Induces Effective and Long Term Inhibition of Influenza A Virus Replication date: 2009-05-22 words: 3531 flesch: 43 summary: 1B showed that the siRNA NP-1496 could inhibit influenza virus replication, while siRNA NP-336 had no inhibition effect, which is consistent with the previous report [25] . In this study we found that siM2 not only decreased the level of M2 mRNA but also the level of NP mRNA, suggesting that siM2 has a broad inhibition manner in the process of influenza virus replication. keywords: cells; gene; h5n1; influenza; inhibition; mdck; replication; sim2; sirna; virus cache: cord-000063-tex6bgab.txt plain text: cord-000063-tex6bgab.txt item: #6 of 672 id: cord-000077-d441jam3 author: Zhang, Hao-Jie title: The Y271 and I274 Amino Acids in Reverse Transcriptase of Human Immunodeficiency Virus-1 Are Critical to Protein Stability date: 2009-07-03 words: 5448 flesch: 46 summary: We tried to demonstrate this in vitro, by treating wild type and mutant RTs with recombinant protease, but wild type RT, as well as mutant RTs, could not be digested in vitro (data not shown). The conformation of the wild type and mutant RT p66 was further analyzed by native gel electrophoresis followed by Western blotting (Fig. 5B) . keywords: cells; fig; gag; immunodeficiency; mutants; mutations; p66; pol; transcriptase; type; virus cache: cord-000077-d441jam3.txt plain text: cord-000077-d441jam3.txt item: #7 of 672 id: cord-000079-533xlisc author: Huszthy, Peter C. title: Remission of Invasive, Cancer Stem-Like Glioblastoma Xenografts Using Lentiviral Vector-Mediated Suicide Gene Therapy date: 2009-07-20 words: 5455 flesch: 41 summary: One major drawback of gammaretroviral vectors is the exclusive transduction of dividing cells, since in human gliomas, the majority of tumor cells do not divide within a given treatment window. LCMV-GP pseudotyped lentiviral vectors exclusively transduced tumor cells in all invasive areas ( Figure 4A ), while normal brain cells were not transduced ( Figure 4B,C) . keywords: brain; cells; figure; gene; glioblastoma; glioma; lcmv; lentiviral; spheroids; stem; tumor; vectors; vsv cache: cord-000079-533xlisc.txt plain text: cord-000079-533xlisc.txt item: #8 of 672 id: cord-000082-jy7j8sh0 author: Huang, Ting title: Evidence of Recombination and Genetic Diversity in Human Rhinoviruses in Children with Acute Respiratory Infection date: 2009-07-27 words: 6209 flesch: 50 summary: However, discrepancies have appeared in the classification of some of the new HRV-A or HRV-C strains, depending on the size and location of the nucleotide sequence in the viral genome and on the phylogenetic methods used for direct analysis of HRV sequences Prior evidence of putative novel rhinovirus species 59 noncoding region alone does not unequivocally determine genetic type of human rhinovirus strains Distinguishing molecular features and clinical characteristics of a putative new rhinovirus species, human rhinovirus C (HRV C) Genome-wide diversity and selective pressure in the human rhinovirus Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses, and bocavirus during acute respiratory tract infections Novel species of human rhinoviruses in acute otitis media Human rhinovirus group C infection in children with lower respiratory tract infection Novel human rhinoviruses and exacerbation of asthma in children Genomic features of intertypic recombinant sabin poliovirus strains excreted by primary vaccinees Recombination in circulating enteroviruses Improved molecular identification of enteroviruses by RT-PCR and amplicon sequencing Co-circulation and evolution of polioviruses and species C enteroviruses in a district of Madagascar Evidence of recombination among enteroviruses Frequency and dynamics of recombination within different species of human enteroviruses Genome analysis of circulating picornavirus reveals rhinovirus recombination and a new enterovirus serotype. keywords: 59utr; hrv; recombination; sequences; species; strains; table; vp2 cache: cord-000082-jy7j8sh0.txt plain text: cord-000082-jy7j8sh0.txt item: #9 of 672 id: cord-000131-ugbwvy6j author: Jones, James Holland title: Early Assessment of Anxiety and Behavioral Response to Novel Swine-Origin Influenza A(H1N1) date: 2009-12-03 words: 4326 flesch: 42 summary: To evaluate the hypothesis that respondents' affective state (subjective anxiety, fatalism about infection) predicts protective measures, we include in the model demographic (age, gender), epidemiological (household size, number of contacts, survey day), and media (source of information on the outbreak) conditioning variables. To develop a measure for this, we cross-tabulated individual values of the protection index and affective status by survey day. keywords: health; influenza; information; media; number; people; respondents; risk; survey cache: cord-000131-ugbwvy6j.txt plain text: cord-000131-ugbwvy6j.txt item: #10 of 672 id: cord-000140-5kapn32k author: Wang, Pei-Gang title: Efficient Assembly and Secretion of Recombinant Subviral Particles of the Four Dengue Serotypes Using Native prM and E Proteins date: 2009-12-15 words: 7785 flesch: 49 summary: 48 hours post-transfection, expression of dengue E protein was monitored by flow cytometry on permeabilized transfected HeLa cells with the 4E11 monoclo-nal antibody against dengue E protein. To generate DV RSPs, we first transfected HeLa cells with native DV1 prME gene derived from the DV1 FGA/NA d1d keywords: antibody; cells; dengue; dv1; figure; genes; golgi; hela; line; membrane; particles; prme; protein; rsps; secretion; supernatant; virus cache: cord-000140-5kapn32k.txt plain text: cord-000140-5kapn32k.txt item: #11 of 672 id: cord-000143-2xvd5ogf author: Napthine, Sawsan title: Expression of the VP2 Protein of Murine Norovirus by a Translation Termination-Reinitiation Strategy date: 2009-12-22 words: 6891 flesch: 47 summary: The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation A bipartite sequence motif induces translation reinitiation in feline calicivirus RNA Expression of the ORF-2 protein of the human respiratory syncytial virus M2 gene is initiated by a ribosomal termination-dependent reinitiation mechanism Coupled translation of the respiratory syncytial virus M2 open reading frames requires upstream sequences Coupled translation of the second open reading frame of M2 mRNA is sequence dependent and differs significantly within the subfamily Pneumovirinae The importance of inter-and intramolecular base pairing for translation reinitiation on a eukaryotic bicistronic mRNA Characterization of the termination-reinitiation strategy employed in the expression of influenza B virus BM2 protein A dualluciferase reporter system for studying recoding signals Ribosome pausing and stacking during translation of a eukaryotic mRNA Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome Migration of 40S ribosomal subunits on messenger RNA in the presence of edeine Migration of 40S ribosomal subunits on messenger RNA when initiation is perturbed by lowering magnesium or adding drugs Mutational analysis of the RNA pseudoknot component of a coronavirus ribosomal frameshifting signal Mutational analysis of the 'slipperysequence' component of a coronavirus ribosomal frameshifting signal Generation of deletion and point mutations with one primer in a single cloning step Two-stage PCR protocol allowing introduction of multiple mutations, deletions and insertions using QuikChange Site-Directed Mutagenesis Structure-function analysis of the ribosomal frameshifting signal of two human immunodeficiency virus type 1 isolates with increased resistance to viral protease inhibitors Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Characterization of the frameshift signal of Edr, a mammalian example of programmed -1 ribosomal frameshifting Distinct protein forms are produced from alternatively spliced bicistronic glutamic acid decarboxylase However, the substantial reintiation activity displayed by MNV49.7, an mRNA in which both AUGs were changed, indicates that non-AUG codons can act as reinitiation codons, although probably at reduced efficiency. keywords: codon; figure; mnv; motif; mrna; orf; reinitiation; start; stop; structure; termination; translation; upstream cache: cord-000143-2xvd5ogf.txt plain text: cord-000143-2xvd5ogf.txt item: #12 of 672 id: cord-000158-d08buwtu author: Corti, Davide title: Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals date: 2010-01-20 words: 8113 flesch: 40 summary: Passive transfer studies in macaques showed that the administration of HIV-1 neutralizing mAbs protects against vaginal or intravenous challenge with SIV-HIV-1 chimeric viruses (SHIV) Furthermore, selective pressure imposed by neutralizing antibodies has been demonstrated in a human trial where three neutralizing monoclonal antibodies (mAbs) administered during HAART treatment-interruption led to a reduction in viremia followed by selection of escape mutants [3, 4] . keywords: activity; antibodies; assay; binding; cells; clade; epitope; gp120; gp41; human; immunodeficiency; isolates; mabs; neutralization; type; virus cache: cord-000158-d08buwtu.txt plain text: cord-000158-d08buwtu.txt item: #13 of 672 id: cord-000166-36bfeoqv author: Tracht, Samantha M. title: Mathematical Modeling of the Effectiveness of Facemasks in Reducing the Spread of Novel Influenza A (H1N1) date: 2010-02-10 words: 5854 flesch: 53 summary: The CDC defines the term facemask as a disposable mask cleared by the U.S. Food and Drug Administration (FDA) for use as a medical device, such as surgical masks. Surgical masks are designed to help stop droplets from being spread by the person wearing the mask, not to protect against breathing in very small particle aerosols that may contain viruses [8] . keywords: cases; h1n1; individuals; masks; n95; number; pandemic; population; wearing cache: cord-000166-36bfeoqv.txt plain text: cord-000166-36bfeoqv.txt item: #14 of 672 id: cord-000176-z76vjkxg author: Nguyen, Jack T. title: Triple Combination of Amantadine, Ribavirin, and Oseltamivir Is Highly Active and Synergistic against Drug Resistant Influenza Virus Strains In Vitro date: 2010-02-22 words: 7360 flesch: 38 summary: However, there have been few reports on the effects of drug combinations on resistant influenza viruses [26, 27, 29] . The impact of influenza epidemics on mortality: introducing a severity index Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from Swine influenza A (H1N1) infection in two children-Southern California Acting Secretary of the U.S. Department of Health and Human Services (2009) Determination that a Public Health Emergency Exists Director-General of the World Health Organization (2009) Swine influenza World now at the start of 2009 influenza pandemic Update: Drug Susceptibility of Swine-Origin Influenza A (H1N1) Viruses Triple combination of oseltamivir, amantadine, and ribavirin displays synergistic activity against multiple influenza virus strains in vitro Cyclopentane neuraminidase inhibitors with potent in vitro anti-influenza virus activities Strategic design and threedimensional analysis of antiviral drug combinations A three-dimensional model to analyze drug-drug interactions Schering Corporation Generation and characterization of recombinant influenza A (H1N1) viruses harboring amantadine resistance mutations Update: Drug Susceptibility of Swine-Origin Influenza A (H1N1) Viruses Current and future antiviral therapy of severe seasonal and avian influenza keywords: amantadine; combination; oseltamivir; regimen; ribavirin; synergy; tcad; tcad regimen cache: cord-000176-z76vjkxg.txt plain text: cord-000176-z76vjkxg.txt item: #15 of 672 id: cord-000180-howix091 author: MacLeod, Iain J. title: Binding of Herpes Simplex Virus Type-1 Virions Leads to the Induction of Intracellular Signalling in the Absence of Virus Entry date: 2010-03-05 words: 6802 flesch: 42 summary: The patterns of accumulation of cellular RNAs in cells infected with a wild-type and a mutant herpes simplex virus 1 lacking the virion host shutoff gene Viral oncoapoptosis of human tumor cells Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death The Bcl2 family: regulators of the cellular life-ordeath switch Innate Cellular Response to Virus Particle Entry Requires IRF3 but Not Virus Replication Identification of a Novel Pathway Essential for the Immediate-Early, Interferon-Independent Antiviral Response to Enveloped Virions Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion Induction of cyclin E-cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events Analysis of cyclin-dependent kinase activity after herpes simplex virus type 2 infection Requirement for Cellular Cyclin-Dependent Kinases in Herpes Simplex Virus Replication and Transcription E2F Proteins Are Posttranslationally Modified Concomitantly with a Reduction in Nuclear Binding Activity in Cells Infected with Herpes Simplex Virus 1 IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors Evidence from previous studies using soluble HSV-1 glycoprotein and UV-inactivated virus suggested that binding of HSV-1 virions to the cell surface might be sufficient to stimulate intracellular signalling pathways. keywords: binding; cell; entry; expression; herpes; hsv-1; infection; particles; signalling; virions; virus cache: cord-000180-howix091.txt plain text: cord-000180-howix091.txt item: #16 of 672 id: cord-000182-ni6iyzdn author: He, Zhisong title: Predicting Drug-Target Interaction Networks Based on Functional Groups and Biological Features date: 2010-03-11 words: 6042 flesch: 37 summary: All the detailed information for the genes and drugs listed here can be found in A guide to drug discovery: Target selection in drug discovery Predicting human safety: screening and computational approaches Assessment of chemical libraries for their druggability Review: Progress in computational approach to drug development against SARS 3D structure modeling of cytochrome P450 2C19 and its implication for personalized drug design Molecular modeling of two CYP2C19 SNPs and its implications for personalized drug design Review: Pharmacogenomics and personalized use of drugs Review: Structure of cytochrome P450s and personalized drug Structure-based maximal affinity model predicts small-molecule druggability A fast flexible docking method using an incremental construction algorithm Review: Structural bioinformatics and its impact to biomedical science Binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against SARS A probabilistic model for mining implicit 'chemical compound-gene' relations from literature Prediction of drug-target interaction networks from the integration of chemical and genomic spaces Statistical prediction of protein chemical interactions based on chemical structure and mass spectrometry data Integrating statistical predictions and experimental verifications for enhancing protein-chemical interaction predictions in virtual screening Alignment-free prediction of a drug-target complex network based on parameters of drug connectivity and protein sequence of receptors A vectorized sequence-coupling model for predicting HIV protease cleavage sites in proteins Review: Prediction of HIV protease cleavage sites in proteins GPCR-CA: A cellular automaton image approach for predicting G-protein-coupled receptor functional classes GPCR-GIA: a web-server for identifying Gprotein coupled receptors and their families with grey incidence analysis Signal-CF: a subsite-coupled and window-fusing approach for predicting signal peptides Using functional domain composition and support vector machines for prediction of protein subcellular location Cell-PLoc: A package of web-servers for predicting subcellular localization of proteins in various organisms Euk-mPLoc: a fusion classifier for large-scale eukaryotic protein subcellular location prediction by incorporating multiple sites A sequence-coupled vector-projection model for predicting the specificity of GalNAc-transferase ProtIdent: A web server for identifying proteases and their types by fusing functional domain and sequential evolution information Prediction of protease types in a hybridization space Prediction of membrane protein types and subcellular locations Low-frequency Fourier spectrum for predicting membrane protein types MemType-2L: A Web server for predicting membrane proteins and their types by incorporating evolution information through Pse-PSSM Support vector machines for predicting membrane protein types by using functional domain composition Review: recent advances in developing web-servers for predicting protein attributes A k-nearest neighbor classification rule based on Dempster-Shafer theory PredAcc: prediction of solvent accessibility Prediction of protein cellular attributes using pseudo amino acid composition Using amphiphilic pseudo amino acid composition to predict enzyme subfamily classes Digital coding of amino acids based on hydrophobic index Feature selection based on mutual information: criteria of max-dependency, max-relevance, and min-redundancy Insights from modelling three-dimensional structures of the human potassium and sodium channels The structure of phospholamban pentamer reveals a channel-like architecture in membranes Mechanism of drug inhibition and drug resistance of influenza A M2 channel Structure and mechanism of the M2 proton channel of influenza A virus Prediction of G-protein-coupled receptor classes Coupling interaction between thromboxane A2 receptor and alpha-13 subunit of guanine nucleotide-binding protein LIGAND: chemical database for enzyme reactions From genomics to chemical genomics: new developments in KEGG Predicting networking couples for metabolic pathways of Evaluating the statistical significance of multiple distinct local alignments A novel approach to predicting protein structural classes in a (20-1)-D amino acid composition space Prediction of protein secondary structure content by using the concept of Chou's pseudo amino acid composition and support vector machine Use of fuzzy clustering technique and matrices to classify amino acids and its impact to Chou's pseudo amino acid composition Using the concept of Chou's pseudo amino acid composition to predict apoptosis proteins subcellular location: an approach by approximate entropy Predicting protein subcellular location using Chou's pseudo amino acid composition and improved hybrid approach The modified Mahalanobis discriminant for predicting outer membrane proteins by using Chou's pseudo amino acid composition Predicting subcellular localization of mycobacterial proteins by using Chou's pseudo amino acid composition Prediction of Subcellular Localization of Apoptosis Protein Using Chou's Pseudo Amino Acid Composition Prediction of G-protein-coupled receptor classes based on the concept of Chou's pseudo amino acid composition: an approach from discrete wavelet transform Using the augmented Chou's pseudo amino acid composition for predicting protein submitochondria locations based on auto covariance approach Predicting the cofactors of oxidoreductases based on amino acid composition distribution and Chou's amphiphilic pseudo amino acid composition Predicting lipase types by improved Chou's pseudo-amino acid composition Using Chou's amphiphilic pseudoamino acid composition and support vector machine for prediction of enzyme subfamily classes Using Chou's pseudo amino acid composition to predict subcellular localization of apoptosis proteins: an approach with immune genetic algorithm-based ensemble classifier Prediction of cell wall lytic enzymes using Chou's amphiphilic pseudo amino acid composition Medicinal chemistry and bioinformatics -current trends in drugs discovery with networks topological indices Proteomics, networks, and connectivity indices Application of pseudo amino acid composition for predicting protein subcellular location: stochastic signal processing approach Weighted-support vector machines for predicting membrane protein types based on pseudo amino acid composition SLLE for predicting membrane protein types Using pseudo amino acid composition to predict protein structural classes: approached with complexity measure factor Using pseudo amino acid composition to predict protein subcellular location: approached with Lyapunov index, Bessel function, and Chebyshev filter Using cellular automata to generate Image representation for biological sequences Using cellular automata images and pseudo amino acid composition to predict protein subcellular location Using pseudo amino acid composition to predict transmembrane regions in protein: cellular automata and Lempel-Ziv complexity Using Pseudo Amino Acid Composition to Predict Protein Structural Class: Approached by Incorporating 400 Dipeptide Components Predicting protein structural classes with pseudo amino acid composition: an approach using geometric moments of cellular automaton image Using grey dynamic modeling and pseudo amino acid composition to predict protein structural classes Predicting membrane protein type by functional domain composition and pseudo amino acid composition Hum-PLoc: A novel ensemble classifier for predicting human protein subcellular localization Large-scale plant protein subcellular location prediction Predicting membrane protein types by the LLDA algorithm Predicting eukaryotic protein subcellular location by fusing optimized evidence-theoretic K-nearest neighbor classifiers Pseudo amino acid composition and its applications in bioinformatics, proteomics and system biology Recognition of a protein fold in the context of the Structural Classification of Proteins (SCOP) classification The classification and origins of protein folding patterns Seventy-five percent accuracy in protein secondary structure prediction Predicting protein folding types by distance functions that make allowances for amino acid interactions A fuzzy k-nearest neighbours algorithm Discriminant Analysis; Chapter 12 Multivariate analysis of variance On the generalized distance in statistics Although there are more features for target than those for drug in the original feature set, more drug features were selected, showing the important role of drugs. keywords: acid; amino; composition; drug; feature; information; interactions; prediction; protein; pseudo; sequence; set; structure; target cache: cord-000182-ni6iyzdn.txt plain text: cord-000182-ni6iyzdn.txt item: #17 of 672 id: cord-000208-th0wddvc author: Cornelissen, Lisette A. H. M. title: A Single Immunization with Soluble Recombinant Trimeric Hemagglutinin Protects Chickens against Highly Pathogenic Avian Influenza Virus H5N1 date: 2010-05-14 words: 5679 flesch: 45 summary: A novel technology for safe and expeditious vaccine production for human use Vaccines for pandemic influenza: summary of recent clinical trials Immunization with live-attenuated influenza viruses expressing altered NS1 proteins results in potent and protective memory CD8+T cells responses Recombinant modified vaccinia virus Ankara-based vaccine induces protective immunity in mice against infection with influenza virus H5N1 Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirusbased immunization A pseudotype baculovirusmediated vaccine confers protective immunity against lethal challenge with H5N1 avian influenza virus in mice and chickens Newcastle disease virus-vectored vaccines expressing the hemagglutinin or neuraminidase protein of H5N1 highly pathogenic avian influenza virus protect against virus challenge in monkeys Multivalent HA DNA vaccination protects against highly pathogenic H5N1 avian influenza infection in chickens and mice Present and future of veterinary viral vaccinology: a review Preparation, characterization, and immunogenicity in mice of a recombinant influenza H5 hemagglutinin vaccine against the avian H5N1 A/Vietnam/1203/ 2004 influenza virus Comparative efficacy of neutralizing antibodies elicited by recombinant hemagglutinin proteins from avian H5N1 influenza virus Baculovirus-derived hemagglutinin vaccines protect against lethal influenza infections by avian H5 and H7 subtypes Nanodisc-incorporated hemagglutinin provides protective immunity against influenza virus infection Glycans on influenza hemagglutinin affect receptor binding and immune response Structure of coronavirus hemagglutinin-esterase offers insight into corona and influenza The highly pathogenic avian influenza (HPAI) virus H5N1 causes multi-organ disease and death in poultry, resulting in significant economic losses in the poultry industry. keywords: challenge; chickens; h5n1; hpai; influenza; mice; protein; sh5; vaccination; vaccine; virus cache: cord-000208-th0wddvc.txt plain text: cord-000208-th0wddvc.txt item: #18 of 672 id: cord-000224-2lz03oqb author: Porter, Kristen A. title: Class II Transactivator (CIITA) Enhances Cytoplasmic Processing of HIV-1 Pr55Gag date: 2010-06-24 words: 6993 flesch: 36 summary: Curiously, CIITA expressing cells produced virus that was significantly more infectious than CIITA deficient cells, and this was independent of the class II antigen presentation pathway. Not only was processing to capsid p24 more complete in CIITA expressing cells, but vector-only control cells and those only expressing HLA-DR contained increased levels of processing intermediates. keywords: cells; ciita; class; expression; figure; gag; hiv; hla; mhc; processing; release; retention; virus cache: cord-000224-2lz03oqb.txt plain text: cord-000224-2lz03oqb.txt item: #19 of 672 id: cord-000237-mticfoic author: Guan, Xuhua title: Pneumonia Incidence and Mortality in Mainland China: Systematic Review of Chinese and English Literature, 1985–2008 date: 2010-07-23 words: 5410 flesch: 47 summary: Thirty-seven published studies met the inclusion criteria ( Figure 1 ); 14 publications included data on pneumonia incidence and 28 publications reported pneumonia mortality estimates. Studies on pneumonia mortality were more geographically representative than studies of pneumonia incidence, and there was at least one study of mortality from each of the six regions (Table S3 ). keywords: age; case; children; china; incidence; mortality; pneumonia; studies; study; years cache: cord-000237-mticfoic.txt plain text: cord-000237-mticfoic.txt item: #20 of 672 id: cord-000248-zueoyesj author: Berretta, Regina title: Cancer Biomarker Discovery: The Entropic Hallmark date: 2010-08-18 words: 33640 flesch: 32 summary: implications for Dunnigan-type familial partial lipodystrophy A-type lamins: guardians of the soma? Downregulation of human X-box binding protein 1 (hXBP-1) expression correlates with tumor progression in human prostate cancers The proapoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1 Gene network and canonical pathway analysis in prostate cancer: a microarray study Biomarker expression patterns that correlate with high grade features in treatment naive, organ-confined prostate cancer NF-kappaB2 processing and p52 nuclear accumulation after androgenic stimulation of LNCaP prostate cancer cells Diverse effects of zinc on NF-kappaB and AP-1 transcription factors: implications for prostate cancer progression Nuclear factor-kappaB nuclear localization is predictive of biochemical recurrence in patients with positive margin prostate cancer Id-1 expression promotes cell survival through activation of NF-kappaB signalling pathway in prostate cancer cells Suppression of hormone-refractory prostate cancer by a novel nuclear factor kappaB inhibitor in nude mice Mechanisms of constitutive NF-kappaB activation in human prostate cancer cells Bcl-2 suppresses apoptosis resulting from disruption of the NF-kappa B survival pathway Gene expression profiling of human prostate cancer stem cells reveals a proinflammatory phenotype and the importance of extracellular matrix interactions Molecular imaging of NF-kappaB in prostate tissue after systemic administration of IL-1 beta TNF/IL-1/NIK/NF-kappa B transduction pathway: a comparative study in normal and pathological human prostate (benign hyperplasia and carcinoma) Proteasome inhibitors induce apoptosis of prostate cancer cells by inducing nuclear translocation of IkappaBalpha Targeting the receptor activator of nuclear factor-kappaB (RANK) ligand in prostate cancer bone metastases Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgenindependent growth A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor Inhibitory effect of snake venom toxin from Vipera lebetina turanica on hormone-refractory human prostate cancer cell growth: induction of apoptosis through inactivation of nuclear factor kappaB Prostate cancer chemoprevention by silibinin: bench to bedside Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest NF-kappaB inhibition increases chemosensitivity to trichostatin A-induced cell death of Ki-Ras-transformed human prostate epithelial cells Involvement of the TNF-alpha autocrine-paracrine loop, via NF-kappaB and YY1, in the regulation of tumor cell resistance to Fas-induced apoptosis Estrogens and antiestrogens as etiological factors and therapeutics for prostate cancer NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells Anticancer potential of silymarin: from bench to bed side Blockage of NF-kappaB induces serine 15 phosphorylation of mutant p53 by JNK kinase in prostate cancer cells Skp2 enhances polyubiquitination and degradation of TIS21/BTG2/PC3, tumor suppressor protein, at the downstream of FoxM1 Triiodothyronine modulates cell proliferation of human prostatic carcinoma cells by downregulation of the B-cell translocation gene 2 B cell translocation gene 2 enhances susceptibility of HeLa cells to doxorubicin-induced oxidative damage TIS21 (/BTG2/PC3) as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule Expression of B-cell translocation gene 2 protein in normal human tissues Antiproliferative B cell translocation gene 2 protein is down-regulated posttranscriptionally as an early event in prostate carcinogenesis Identification of genes associated with stromal hyperplasia and glandular atrophy of the prostate by mRNA differential display Role of connective tissue growth factor in fibronectin synthesis in cultured human prostate stromal cells Stromal expression of connective tissue growth factor promotes angiogenesis and prostate cancer tumorigenesis Analysis of gene expression during staurosporine-induced neuronal differentiation of human prostate cancer cells Profiling molecular targets of TGF-beta1 in prostate fibroblast-to-myofibroblast transdifferentiation Expression of androgen receptor coregulatory proteins in prostate cancer and stromal-cell culture models FHL2, a novel tissue-specific coactivator of the androgen receptor Four and a Half LIM Domain 2 alters the impact of Aryl Hydrocarbon Receptor on Androgen Receptor transcriptional activity Differently regulated androgen receptor transcriptional complex in prostate cancer compared with normal prostate Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus Functional epigenomics identifies genes frequently silenced in prostate cancer Expression level and DNA methylation status of glutathione-S-transferase genes in normal murine prostate and TRAMP tumors Function of JunB in transient amplifying cell senescence and progression of human prostate cancer KAI1 promoter activity is dependent on p53, junB and AP2: evidence for a possible mechanism underlying loss of KAI1 expression in cancer cells Inhibition of prostate tumor growth by overexpression of NudC, a microtubule motorassociated protein Control of androgen receptor signaling in prostate cancer by the cochaperone small glutamine rich tetratricopeptide repeat containing protein alpha Signal transducer and activator of transcription-6 (STAT6) is a constitutively expressed survival factor in human prostate cancer Robust prostate cancer marker genes emerge from direct integration of inter-study microarray data Molecular features of the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer: genome-wide gene-expression profiles of prostate cancers and PINs Analysis of integrin alpha7 mutations in prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma The biology of cancer The chromosomal basis of cancer Gene panel model predictive of outcome in men at high-risk of systemic progression and death from prostate cancer after radical retropubic prostatectomy Aneuploidy and rapid cell proliferation in recurrent prostate cancers with androgen receptor gene amplification Prognostic value of DNA analysis of prostate adenocarcinoma: correlation to clinicopathologic predictors Heterogeneity in prostate cancer: Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator Alphamethylacyl-CoA racemase-an 'obscure' metabolic enzyme takes centre stage Biopsy tissue microarray study of Ki-67 expression in untreated, localized prostate cancer managed by active surveillance Alpha-methylacyl-CoA racemase (P504S) expression in evolving carcinomas within benign prostatic hyperplasia and in cancers of the transition zone Expression of alpha-methylacyl-CoA racemase (P504s) in various malignant neoplasms and normal tissues: astudy of 761 cases Using an AMACR (P504S)/34betaE12/p63 cocktail for the detection of small focal prostate carcinoma in needle biopsy specimens Diagnostic utility of alpha-methylacyl CoA racemase (P504S) on prostate needle biopsy Discovery and clinical application of a novel prostate cancer marker: alpha-methylacyl CoA racemase (P504S) Alphamethylacyl-CoA racemase: a multi-institutional study of a new prostate cancer marker Quantitative immunohistochemical detection of the molecular expression patterns in proliferative inflammatory atrophy The importance of determining the aggressiveness of prostate cancer using serum and tissue molecular markers GOLPH2 protein expression as a novel tissue biomarker for prostate cancer: implications for tissue-based diagnostics Optimization of laser capture microdissection and RNA amplification for gene expression profiling of prostate cancer ) alpha-Methylacyl-CoA racemase: expression levels of this novel cancer biomarker depend on tumor differentiation Elevated alpha-methylacyl-CoA racemase enzymatic activity in prostate cancer Comparison of monoclonal antibody (P504S) and polyclonal antibody to alpha methylacyl-CoA racemase (AMACR) in the work-up of prostate cancer Immunohistochemical detection of carcinoma in radical prostatectomy specimens following hormone therapy Basal cell subpopulation as putative human prostate carcinoma stem cells A statistical method for identifying differential gene-gene co-expression patterns Alphamethylacyl-CoA racemase (AMACR/P504S) protein expression in urothelial carcinoma of the upper urinary tract correlates with tumour progression Sequence variation in alpha-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer Malignant transformation of human benign prostate epithelial cells by high linear energy transfer alpha-particles Expression of alpha-methylacylcoenzyme A racemase in dysplastic Barrett's epithelium Quantitative analysis of a panel of gene expression in prostate cancer-with emphasis on NPY expression analysis The value of using an AMACR/34betaE12/p63 cocktail double staining for diagnosis of prostate carcinoma Decreased gene expression of steroid 5 alpha-reductase 2 in human prostate cancer: implications for finasteride therapy of prostate carcinoma Alpha-methylacyl-CoA racemase: a new molecular marker for prostate cancer Alpha-methylacyl-CoA racemase: a variably sensitive immunohistochemical marker for the diagnosis of small prostate cancer foci on needle biopsy Neoadjuvant docetaxel treatment for locally advanced prostate cancer: a clinicopathologic study Biomarkers for Prostate Cancer Method for quantification of a prostate cancer biomarker in urine without sample preparation Effects of the dual 5 alpha-reductase inhibitor dutasteride on apoptosis in primary cultures of prostate cancer epithelial cells and cell lines Routine immunohistochemical staining for high-molecular weight cytokeratin 34-beta and alpha-methylacyl CoA racemase (P504S) in postirradiation prostate biopsies Search for residual prostate cancer on pT0 radical prostatectomy after positive biopsy Branched fatty acids in dairy and beef products markedly enhance alpha-methylacyl-CoA racemase expression in prostate cancer cells in vitro Alpha-methyl CoA racemase expression in renal cell carcinomas Diagnostic utility of a p63/alpha-methyl-CoA-racemase (p504s) cocktail in atypical foci in the prostate Value of new prostate cancer markers: alpha methylacyl CoA racemase (P504S) and p63 Evaluation of p63 and p504s markers for the diagnosis of prostate cancer keywords: alpha; analysis; associated; biomarkers; cancer cells; cancer progression; cell; changes; coa; complexity; correlation; dataset; distribution; divergence; dna; expression; factor; figure; function; gene; gene expression; gleason; growth; human; information; jensen; kinase; loss; malignant; melanoma; metastasis; methylacyl; normalized; normalized shannon; novel; osteopontin; probes; profile; progression; prostate cancer; protein; racemase; regulation; results; role; samples; shannon; shannon divergence; shannon entropy; skin; study; tissue; transcriptional; tumor; values cache: cord-000248-zueoyesj.txt plain text: cord-000248-zueoyesj.txt item: #21 of 672 id: cord-000255-73nlxqgk author: Hosseini, Parviez title: Predictive Power of Air Travel and Socio-Economic Data for Early Pandemic Spread date: 2010-09-15 words: 4022 flesch: 44 summary: Such that eventually we may be able to predict viral emergence and develop vaccines against pandemic influenza viruses in advance of their spread. CONCLUSIONS/SIGNIFICANCE: We conclude that strategies to prevent pandemic influenza virus emergence and spread in the future should include: 1) enhanced surveillance for strains resulting from reassortment in traded livestock; 2) rapid deployment of control measures in the initial spreading phase to countries where travel data predict the pathogen will reach and to countries where lower healthcare resources will likely cause delays in reporting. keywords: countries; data; h1n1; healthcare; influenza; pandemic; spread; virus cache: cord-000255-73nlxqgk.txt plain text: cord-000255-73nlxqgk.txt item: #22 of 672 id: cord-000261-ip32y0j5 author: Becker, Pablo D. title: Generation of Human Antigen-Specific Monoclonal IgM Antibodies Using Vaccinated “Human Immune System” Mice date: 2010-10-04 words: 5828 flesch: 41 summary: Thus, to fully exploit the Ig repertoire of human B cells in an in vivo setting, we explored the possibility to raise mAbs following de novo induction of human B cell responses in mice carrying elements of the human immune system (HIS). Similarly to methods based on the immortalization of human memory B cells from individuals that were either vaccinated or exposed to pathogens, our strategy exploits the antibody repertoire of human B cells which is likely to be different from that of B cells of mice expressing human Ig gene segments. keywords: antibodies; antigen; cells; clones; human; igg; igm; mabs; mice; mouse; specific; vaccinated cache: cord-000261-ip32y0j5.txt plain text: cord-000261-ip32y0j5.txt item: #23 of 672 id: cord-000265-llilwq1u author: Gao, Rongbao title: A Systematic Molecular Pathology Study of a Laboratory Confirmed H5N1 Human Case date: 2010-10-12 words: 4904 flesch: 41 summary: Global public health concerns surrounding H5N1 viruses include not only individual transmission events between infected poultry and individual humans, but also their pandemic potential, should these viruses acquire genetic changes that result in sustained human-to-human transmission. Reactive hemophagocytosis in multiple organs, and occasional detection of viral antigen or viral RNA in extrapulmonary organs suggest a broader tissue distribution of H5N1 viruses compared with seasonal viruses in fatal human cases [21, 22] . keywords: avian; cells; gene; h5n1; human; infection; influenza; load; lung; tissues; virus; viruses cache: cord-000265-llilwq1u.txt plain text: cord-000265-llilwq1u.txt item: #24 of 672 id: cord-000266-xwfptmmv author: Liao, Qiuyan title: Situational Awareness and Health Protective Responses to Pandemic Influenza A (H1N1) in Hong Kong: A Cross-Sectional Study date: 2010-10-12 words: 7135 flesch: 40 summary: This suggests that these two items measure different aspects of social information. If mixed social messages occur signalling uncertainty then the utility of social information will fall. keywords: distancing; efficacy; h1n1; hand; health; influenza; information; model; self; social; trust; worry cache: cord-000266-xwfptmmv.txt plain text: cord-000266-xwfptmmv.txt item: #25 of 672 id: cord-000267-xroo7z7g author: Xiao, Xiaodong title: Human Anti-Plague Monoclonal Antibodies Protect Mice from Yersinia pestis in a Bubonic Plague Model date: 2010-10-13 words: 7386 flesch: 54 summary: Human anti-F1and anti-V mAbs show synergistic protection when used together in the murine bubonic plague model. [13] , and anti-V mouse mAbs 10-1 m, 74-1 m, 84-1 m, and 141-1 m as well as the control IgG1 mouse anti-Burkholderia mallei (Bm) antibody were obtained from Sylvia Trevino (USAMRIID) and anti-V mouse mAb 7.3 (7.3 m) was obtained from Jim Hill (Porton Down, Wiltshire, UK) keywords: anti; antigen; human; m252; mab; mabs; mice; mouse; pestis; plague cache: cord-000267-xroo7z7g.txt plain text: cord-000267-xroo7z7g.txt item: #26 of 672 id: cord-000269-v4jochbe author: Wittekindt, Nicola E. title: Nodeomics: Pathogen Detection in Vertebrate Lymph Nodes Using Meta-Transcriptomics date: 2010-10-18 words: 5897 flesch: 40 summary: A comparison of the three methods used to detect bacteria in mule deer lymph node samples is shown for MD 257 in Figure 2 and for MD 80228 and MD OCT-pool in Figure S1 . The microbial community of mule deer lymph nodes Detection of protein-coding and ribosomal RNA transcripts provides strong support for the presence of viable and replicating microorganisms. keywords: cdna; database; deer; helicobacter; libraries; lymph; microbial; pool; rna; rrna; sequencing; tags; transcripts cache: cord-000269-v4jochbe.txt plain text: cord-000269-v4jochbe.txt item: #27 of 672 id: cord-000321-ee7q7jhv author: Powell, Michael L. title: Further Characterisation of the Translational Termination-Reinitiation Signal of the Influenza B Virus Segment 7 RNA date: 2011-02-08 words: 9480 flesch: 46 summary: A bipartite sequence motif induces translation reinitiation in feline calicivirus RNA The importance of inter-and intramolecular base pairing for translation reinitiation on a eukaryotic bicistronic mRNA The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation Translation of the minor capsid protein of a calicivirus is initiated by a novel termination-dependent reinitiation mechanism Characterization of the sequence element directing translation reinitiation in RNA of the calicivirus rabbit hemorrhagic disease virus Expression of the VP2 protein of murine norovirus by a translation terminationreinitiation strategy A dualluciferase reporter system for studying recoding signals Translational readthrough of the PDE2 stop codon modulates cAMP levels in Saccharomyces cerevisiae Versatile vectors to study recoding: conservation of rules between yeast and mammalian cells Two-stage PCR protocol allowing introduction of multiple mutations, deletions and insertions using QuikChange Site-Directed Mutagenesis Structure-function analysis of the ribosomal frameshifting signal of two human immunodeficiency virus type 1 isolates with increased resistance to viral protease inhibitors Truncated initiation factor eIF4G lacking an eIF4E binding site can support capped mRNA translation Transformation of yeast by lithium acetate/singlestranded carrier DNA/polyethylene glycol method A 9-nt segment of a cellular mRNA can function as an internal ribosome entry site (IRES) and when present in linked multiple copies greatly enhances IRES activity Biochemical and functional analysis of a 9-nt RNA sequence that affects translation efficiency in eukaryotic cells An mRNA-rRNA basepairing mechanism for translation initiation in eukaryotes rRNA-complementarity in the 59 untranslated region of mRNA specifying the Gtx homeodomain protein: evidence that base-pairing to 18S rRNA affects translational efficiency Expression of the ORF-2 protein of the human respiratory syncytial virus M2 gene is initiated by a ribosomal termination-dependent reinitiation mechanism Translation termination reinitiation between open reading frame 1 (ORF1) and ORF2 enables capsid expression in a bovine norovirus without the need for production of viral subgenomic RNA The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation Antisense masking reveals contributions of mRNA-rRNA base pairing to translation of Gtx and FGF2 mRNAs Recycling of eukaryotic posttermination ribosomal complexes As expected, termination reinitiation was significantly (p,0.01) reduced in pAC99-yeastps, although there was still some background synthesis of fluc ( Figure 4C ). keywords: 18s; aug; bm2; codon; downstream; figure; motif; mrna; reinitiation; rrna; stop; termination; translation; turbs cache: cord-000321-ee7q7jhv.txt plain text: cord-000321-ee7q7jhv.txt item: #28 of 672 id: cord-000322-8ctsa9sd author: Ninove, Laetitia title: RNA and DNA Bacteriophages as Molecular Diagnosis Controls in Clinical Virology: A Comprehensive Study of More than 45,000 Routine PCR Tests date: 2011-02-09 words: 2897 flesch: 36 summary: Protocols for real time PCR detection of phages TA and MS2 were elaborated in various formats and are described in Supporting Information S2. When IDP was associated with negative PCR detection results, a new assay was performed using a tenfold dilution of the nucleic acid extract. keywords: detection; dna; pcr; rna; samples; time cache: cord-000322-8ctsa9sd.txt plain text: cord-000322-8ctsa9sd.txt item: #29 of 672 id: cord-000326-a18rch1f author: Zhou, Jun-Wei title: Apolipoprotein M Gene (APOM) Polymorphism Modifies Metabolic and Disease Traits in Type 2 Diabetes date: 2011-02-24 words: 4847 flesch: 46 summary: One SNP (rs805264) with significant result (p,0.001) indicative of informative missingness (IM) was excluded for further T2D association analyses (Supplelmentary Table S2 ). Results presented by Han et al. from the study of a Northern Chinese cohort showed significant association between rs707922 T allele and increased risk of cerebral infraction (OR = 1.78, p = 0.000). keywords: apom; association; chinese; cholesterol; diabetes; gene; metabolic; patients; plasma; rs707922; snps; t2d; traits cache: cord-000326-a18rch1f.txt plain text: cord-000326-a18rch1f.txt item: #30 of 672 id: cord-000336-57es391o author: Liao, Qiuyan title: Factors Affecting Intention to Receive and Self-Reported Receipt of 2009 Pandemic (H1N1) Vaccine in Hong Kong: A Longitudinal Study date: 2011-03-11 words: 7654 flesch: 36 summary: [50] : vaccination history and anticipated regret respectively accounted for an additional 10.7% and 13.7% of total variance in influenza vaccination intention [50] . A meta-analysis of the experimental evidence Statistical power analysis for the behavioral sciences Social foundataions of thought and action: a social cognitive theory Implementation intentions: strong effects of simple plans Implementation intentions and goal achievement: a meta-analysis of effects and processes Augmenting the Theory of Planned Behavior: roles for anticipated regret and descriptive norms Acting on intentions: the role of anticipated regret Determinants of older adults' intentions to vaccinate against influenza: a theoretical application Determinants of influenza vaccination among healthcare workers Situational awareness and health protective responses to pandemic influenza A (H1N1) in Hong Kong: a cross-sectional study Community psychological and behavioral responses through the first wave of 2009 pandemic (H1N1) in Hong Kong Power analysis and determination of sample size for covariance structure modeling Principles and practice of structural equation modeling A meta-analysis of Cronbach's coeffient alpha Efficacy of an extended theory of planned behaviour model for predicting caterers' hand hygiene practices Combining behavioral theories to predict recycling involvement An outbreak of the severe acute respiratory syndrome: predictors of health behaviors and effect of community prevention measures in Hong Kong, China Psychosocial factors influencing the practice of preventive behaviors against the severe acute respiratory syndrome among older Chinese in Hong Kong Main tables of the 2006 population census. keywords: influenza; intention; pandemic; ph1n1; planning; regret; respondents; study; uptake; vaccination; vaccine cache: cord-000336-57es391o.txt plain text: cord-000336-57es391o.txt item: #31 of 672 id: cord-000341-d3a06n3f author: Xu, Wanghui title: Screening of Random Peptide Library of Hemagglutinin from Pandemic 2009 A(H1N1) Influenza Virus Reveals Unexpected Antigenically Important Regions date: 2011-03-18 words: 6903 flesch: 43 summary: The major alternative approaches for epitope mapping are derived from scanning with antigenic peptides displayed on the surface of bacteriophage, bacteria and yeast Screening of antigenic peptides recognized by mouse antisera immunized with HA protein We first screened the yeast library displaying the H1N1 HA peptides to study the murine immune response to recombinant HA protein of the 2009 A(H1N1) Influenza virus. keywords: antibodies; antigenic; antisera; cells; fig; ha1; influenza; peptides; protein; region; residues; yeast cache: cord-000341-d3a06n3f.txt plain text: cord-000341-d3a06n3f.txt item: #32 of 672 id: cord-000346-9b6yz3f4 author: Holder, Benjamin P. title: Assessing the In Vitro Fitness of an Oseltamivir-Resistant Seasonal A/H1N1 Influenza Strain Using a Mathematical Model date: 2011-03-24 words: 7509 flesch: 42 summary: The growth of viral plaques during the enlargment phase Replication of viruses in a growing plaque: A reactiondiffusion model Time-delayed spread of viruses in growing plaques Parameter identifiability and estimation of HIV/AIDS dynamic models New low-viscosity overlay medium for viral plaque assays A simple and fast method for determining colony forming units Assessing the viral fitness of oseltamivir-resistant influenza viruses in ferrets, using a competitive-mixtures model Fluorometric assay of neuraminidase with a sodium (4-methylumbelliferyl-a-D-N-acetylneruaminate) substrate Advanced biochemistry: Protein properties and kinetics (BTC 560) -Course website Exploring the effect of biological delays in kinetic models of influenza within a host or cell culture Induction of programmed cell death (apoptosis) by influenza virus infection in tissue culture cells Apoptosis: A mechanism of cell killing by influenza A and B viruses NS1 protein of influenza A virus down-regulates apoptosis Impairment of multicycle influenza virus growth in Vero (WHO) cells by loss of trypsin activity Mode of action of the anti-influenza virus activity of plant flavonoid, 5,7,49-trihydroxy-8-methoxyflavone, from the roots of Scutellaria baicalensis The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 29-59 oligo(A) synthetase/ We have shown, however, in earlier work where influenza virus plaques were observed by immunostaining [41] , that the same plaque velocity can be measured from both the progress of dead cells, as we consider here, and the progress of newly infected cells. keywords: cell; growth; h275y; infection; influenza; mutant; plaque; rate; strain; time; titer; virus; yield cache: cord-000346-9b6yz3f4.txt plain text: cord-000346-9b6yz3f4.txt item: #33 of 672 id: cord-000347-gdra8xhj author: Gibbons, Henry S. title: Genomic Signatures of Strain Selection and Enhancement in Bacillus atrophaeus var. globigii, a Historical Biowarfare Simulant date: 2011-03-25 words: 9621 flesch: 38 summary: Phase-contrast microscopy of BG strains after two days of growth on SBA. WGS of variants revealed that several strains were mixed but highly related populations and uncovered a progressive accumulation of mutations among the “military” isolates. keywords: analysis; atrophaeus; bacillus; bacillus subtilis; detrick; figure; genome; genomic; growth; isolates; lineage; military; mutations; phenotype; selection; sequence; sequencing; simulant; sporulation; strains; subtilis cache: cord-000347-gdra8xhj.txt plain text: cord-000347-gdra8xhj.txt item: #34 of 672 id: cord-000352-qzkpik3z author: Carvalho, Gabrielle title: Participation of the Cell Polarity Protein PALS1 to T-Cell Receptor-Mediated NF-κB Activation date: 2011-03-30 words: 2620 flesch: 43 summary: In T lymphocytes, cell polarity proteins were shown to partition the leading edge from the uropod at the cell rear, and therefore participate to cell migration, homing, and scanning [4, 5, 6] . Altogether, our results strengthen the unexpected function of cell polarity proteins in lymphocyte proliferation [7, 8, 9, 10] , and unveil an original role for PALS1 during TCR-mediated NF-kB activation. keywords: activation; cell; figure; pals1; polarity; protein cache: cord-000352-qzkpik3z.txt plain text: cord-000352-qzkpik3z.txt item: #35 of 672 id: cord-000359-y0m1utug author: Walpita, Pramila title: Vaccine Potential of Nipah Virus-Like Particles date: 2011-04-06 words: 7812 flesch: 41 summary: The coming of age of virus-like particle vaccines Immunodrugs: therapeutic VLP-based vaccines for chronic diseases Ebola virus-like particle-based vaccine protects nonhuman primates against lethal Ebola virus challenge Human parainfluenza virus type 1 matrix and nucleoprotein genes transiently expressed in mammalian cells induce the release of virus-like particles containing nucleocapsid-like structures Requirements for the assembly and release of Newcastle disease virus-like particles Requirements for budding of paramyxovirus simian virus 5 virus-like particles Paramyxovirus Sendai virus-like particle formation by expression of multiple viral proteins and acceleration of its release by C protein Identification of the respiratory syncytial virus proteins required for formation and passage of helper-dependent infectious particles Quantitative analysis of Nipah virus proteins released as virus-like particles reveals central role for the matrix protein Assembly and biological and immunological properties of Newcastle disease virus-like particles Receptor binding, fusion inhibition, and induction of cross-reactive neutralizing antibodies by a soluble G glycoprotein of Hendra virus Membrane fusion tropism and heterotypic functional activities of the Nipah virus and Hendra virus envelope glycoproteins Paramyxoviridae: the viruses and their replication Correlates of protection induced by vaccination Neutralization of animal virus infectivity by antibody Antibody prophylaxis and therapy against Nipah virus infection in hamsters Efficient selection for high-expression transfectants with a novel eukaryotic vector Cis-acting elements in the antigenomic promoter of Nipah virus Chimeric coronavirus-like particles carrying severe acute respiratory syndrome coronavirus (SCoV) S protein protect mice against challenge with SCoV Cells that express all five proteins of vesicular stomatitis virus from cloned cDNAs support replication, assembly, and budding of defective interfering particles The 59 terminal trailer region of vesicular stomatitis virus contains a position-dependent cis-acting signal for assembly of RNA into infectious particles Structure of the recombinant alphavirus Western equine encephalitis virus revealed by cryoelectron microscopy Reverse genetics of negative-stranded RNA viruses: a global perspective Elucidation of Nipah virus morphogenesis and replication using ultrastructural and molecular approaches Ultrastructure of Hendra virus and Nipah virus within cultured cells and host animals A mature and fusogenic form of Nipah virus F protein requires proteolytic TLRs and innate immunity Regulation of adaptive immunity by the innate immune system Combined administration with DNA encoding vesicular stomatitis virus G protein enhances DNA vaccine potency Preliminary analysis of the requirements for fusion from within and fusion from without by Newcastle disease virus Innate cellular response to virus particle entry requires IRF3 but not virus replication Virus-like particle-induced fusion from without in tissue culture cells: role of outer-layer proteins VP4 and VP7 Fusion from without directed by human immunodeficiency virus particles Studies of membrane fusion. The budding capacity of virus proteins as VLPs, the proteinprotein interactions that facilitate this process, and the central role of M protein in VLP assembly and release has been described for several paramyxoviruses such as Sendai virus (SeV), Newcastle disease virus (NDV), respiratory syncytial virus (RSV), paramyxovirus simian virus 5 (PIV-5) and human parainfluenza virus type 1 (hPIV1) keywords: antibody; cells; expression; figure; formation; nipah; niv; particles; proteins; response; surface; vaccine; virus; vlps cache: cord-000359-y0m1utug.txt plain text: cord-000359-y0m1utug.txt item: #36 of 672 id: cord-000366-u4649rtx author: Shan, Tongling title: Genomic Characterization and High Prevalence of Bocaviruses in Swine date: 2011-04-15 words: 2927 flesch: 50 summary: Virus Taxonomy: The Eighth Report of the International Committee on Taxonomy of Viruses Animal bocaviruses: a brief review Complete nucleotide sequence and genome organization of bovine parvovirus Recovery and characterization of a minute virus of canines Human bocaviruses are highly diverse, dispersed, recombination prone, and prevalent in enteric infections Identification and characterization of a new bocavirus species in gorillas Widespread infection of chimpanzees and gorillas with homologues of human parvoviruses B19, PARV4 and human bocavirus in the wild Cloning of a human parvovirus by molecular screening of respiratory tract samples A novel bocavirus associated with acute gastroenteritis in Australian children A newly identified bocavirus species in human stool Human bocavirus Human bocavirus and acute wheezing in children Detection of human bocavirus in Canadian children in a 1-year study Human bocavirus infection in hospitalized children during winter Bocavirus infection in hospitalized children Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand Human bocavirus respiratory infections in children Clinical and molecular epidemiology of human bocavirus in respiratory and fecal samples from children in Hong Kong Human bocavirus infection in children with gastroenteritis Role of Human Bocavirus infections in outbreaks of gastroenteritis Human bocavirus-a novel parvovirus to infect humans No gastroenteric Bocavirus in high risk patients stool samples Human bocavirus infection in children with acute gastroenteritis and healthy controls Human bocavirus in an immunocompromised child presenting with severe diarrhea The first detection of human bocavirus 2 infections in China Frequent detection of highly diverse variants of cardiovirus, cosavirus, bocavirus, and circovirus in sewage samples collected in the United States Detection of a novel porcine boca-like virus in the background of porcine circovirus type 2 induced postweaning multisystemic wasting syndrome Identification and nearly full-length genome characterization of novel porcine bocaviruses Identification of a third human polyomavirus Using primer walking, we sequenced the nearly complete genomes of two highly divergent bocaviruses we provisionally named porcine bocavirus 1 isolate H18 (PBoV1-H18) and porcine bocavirus 2 isolate A6 (PBoV2-A6) which differed by 51.8% in their NS1 protein. keywords: bocavirus; children; h18; human; pbov1; porcine; samples cache: cord-000366-u4649rtx.txt plain text: cord-000366-u4649rtx.txt item: #37 of 672 id: cord-000374-gt2pwc9b author: Yang, Albert C. title: Clustering Heart Rate Dynamics Is Associated with β-Adrenergic Receptor Polymorphisms: Analysis by Information-Based Similarity Index date: 2011-05-04 words: 5317 flesch: 36 summary: Fractal dynamics in physiology: alterations with disease and aging Heritability of heart rate variability: the Framingham Heart Study Heritability of ambulatory heart rate variability Ethnic differences and heritability of heart rate variability in African-and European American youth Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study Inheritance of heart rate variability: the kibbutzim family study Pleiotropy of Creactive protein gene polymorphisms with C-reactive protein levels and heart rate variability in healthy male twins Angiotensin-converting enzyme and angiotensinogen gene polymorphisms and heart rate variability in twins Heart rate variability is associated with polymorphic variation in the choline transporter gene Association of UCP2 and UCP3 polymorphisms with heart rate variability in Japanese men Association of beta-adrenoceptor polymorphisms with cardiac autonomic modulation in Japanese males BDNF Val66Met polymorphism alters sympathovagal balance in healthy subjects Reduced physiological complexity in robust elderly adults with the APOE epsilon4 allele A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate Adrenergic receptor polymorphisms associated with resting heart rate: the HyperGEN Study Statistical physics approach to categorize biologic signals: from heart rate dynamics to DNA sequences Linguistic analysis of the human heartbeat using frequency and rank order statistics PhysioBank, PhysioToolkit, and PhysioNet: components of a new research resource for complex physiologic signals Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology: Heart rate variability: standards of measurement, physiological interpretation and clinical use The pNNx files: re-examining a widely used heart rate variability measure Relationship of heart rate variability to parasympathetic effect Respiratory sinus arrhythmia: noninvasive measure of parasympathetic cardiac control Assessment of autonomic function in humans by heart rate spectral analysis Power spectrum analysis of heart rate variability: a tool to explore neural regulatory mechanisms Mechanisms underlying very-low-frequency RR-interval oscillations in humans Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series Long-range correlations in nucleotide sequences Multiscale entropy analysis of complex physiologic time series Fractal analysis of heart rate dynamics as a predictor of mortality in patients with depressed left ventricular function after acute myocardial infarction. TRAndolapril Cardiac Evaluation Dynamic analysis of heart rate may predict subsequent ventricular tachycardia after myocardial infarction Predicting survival in heart failure case and control subjects by use of fully automated methods for deriving nonlinear and conventional indices of heart rate dynamics Fractal analysis of heart rate variability and mortality after an acute myocardial infarction Novel method to quantify loss of heart rate variability in pediatric multiple organ failure Fractal correlation properties of R-R interval dynamics and mortality in patients with depressed left ventricular function after an acute myocardial infarction The prognostic value of non-linear analysis of heart rate variability in patients with congestive heart failure-A pilot study of multiscale entropy Symbolic dynamics of heart rate variability: a probe to investigate cardiac autonomic modulation Entropy, entropy rate, and pattern classification as tools to typify complexity in short heart period variability series Quantitative analysis of heart rate variability Short-term forecasting of life-threatening cardiac arrhythmias based on symbolic dynamics and finite-time growth rates Nonlinear measures of heart period variability: decreased measures of symbolic dynamics in patients with panic disorder Information categorization approach to literary authorship disputes Genomic classification using an information-based similarity index: application to the SARS coronavirus A mathematical theory of communication Linear and non-linear indices of heart rate variability in chronic heart failure: mutual interrelationships and prognostic value Nonrandomness index applied for heart rate variability in surgical intensive care units using frequency and rank order statistics Nonlinear indices of heart rate variability in chronic heart failure patients: redundancy and comparative clinical value Polymorphism in the beta(1)-adrenergic receptor gene and hypertension Effects of beta1-adrenoceptor genetic polymorphisms on resting hemodynamics in patients undergoing diagnostic testing for ischemia Overexpression of human beta2-adrenergic receptors increases gain of excitationcontraction coupling in mouse ventricular myocytes Beta-adrenoceptor polymorphisms and heart failure Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies Arg16Gly polymorphism of the beta2-adrenergic receptor is associated with differences in cardiovascular function at rest and during exercise in humans Beta2-adrenoceptor polymorphisms relate to insulin resistance and sympathetic overactivity as early markers of metabolic disease in nonobese, normotensive individuals Beta2-and beta3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 years keywords: -ar; analysis; heart; hrv; ibs; index; polymorphisms; rate; study; subjects cache: cord-000374-gt2pwc9b.txt plain text: cord-000374-gt2pwc9b.txt item: #38 of 672 id: cord-000375-fvfl0bn1 author: Shen, Ching-I title: The Infection of Chicken Tracheal Epithelial Cells with a H6N1 Avian Influenza Virus date: 2011-05-06 words: 4049 flesch: 48 summary: Tracheal/ bronchial epithelium, mainly consisting of ciliated cells, goblet cells and basal cells, is the initially attacked tissue by the invading influenza viruses. Although SAa2-3Gal expression was relatively low in goblet and basal cells, still 21.360.05% of goblet cells and 51.1610.9% of basal cells were infected. keywords: 3gal; cells; goblet; influenza; maa; mal; saa2; virus; viruses cache: cord-000375-fvfl0bn1.txt plain text: cord-000375-fvfl0bn1.txt item: #39 of 672 id: cord-000408-pt3b4yc7 author: Lu, Sydney X. title: Ceacam1 Separates Graft-versus-Host-Disease from Graft-versus-Tumor Activity after Experimental Allogeneic Bone Marrow Transplantation date: 2011-07-06 words: 5467 flesch: 41 summary: In our model systems, WT T cells in a Ceacam1-deficient environment showed a phenotype similar to that of Ceacam1 2/2 alloactivated T cells: both showed increased activation, selective damage to the large intestines, and preferential accumulation in the MLN and intestinal parenchyma of mice with GVHD, and correspondingly decreased infiltration of the liver and PLN, ultimately leading to exacerbation of disease, with accelerated mortality in the first two weeks post-transplant. Carcinoembryonic antigen related cell adhesion molecule 1 (Ceacam1) is a transmembrane glycoprotein found on epithelium, T cells, and many tumors. keywords: allo; bmt; ceacam1; cells; donor; figure; gvhd; mice; recipients; t cells cache: cord-000408-pt3b4yc7.txt plain text: cord-000408-pt3b4yc7.txt item: #40 of 672 id: cord-000410-av8b8g8c author: Radoshitzky, Sheli R. title: Machupo Virus Glycoprotein Determinants for Human Transferrin Receptor 1 Binding and Cell Entry date: 2011-07-07 words: 3443 flesch: 51 summary: TfR1 residues essential for this interaction have been described, and a co-crystal of MACV GP1 bound to TfR1 suggests GP1 residues important for this association. We created MACV GP1 variants and tested their effect on TfR1 binding and virus entry to evaluate the functional significance of some of these and additional residues in human and simian cells. keywords: arenaviruses; binding; cell; entry; fig; gp1; htfr1; macv; receptor; residues cache: cord-000410-av8b8g8c.txt plain text: cord-000410-av8b8g8c.txt item: #41 of 672 id: cord-000413-h2e6h076 author: Zhang, Jingyu title: A Conformation-Sensitive Monoclonal Antibody against the A2 Domain of von Willebrand Factor Reduces Its Proteolysis by ADAMTS13 date: 2011-07-11 words: 4477 flesch: 46 summary: The mAb VP-1, which was directly against residues 1591-1605 (inside VWF A2 domain) of VWF polypeptide, inhibited the susceptibility of the recombinant type 2A VWF mutants R1606W and R1606Q to proteolytic cleavage by ADAMTS13 under the static condition. Our data demonstrate that the epitope of SZ34, a mAb raised against native VWF multimers, is located within the A1555-G1595 region, which comprises the a2-helix and a3-helix according to the crystal structure of VWF A2 domain [19] . keywords: adamts13; cleavage; domain; factor; mab; proteolysis; sz34; von; vwf; willebrand cache: cord-000413-h2e6h076.txt plain text: cord-000413-h2e6h076.txt item: #42 of 672 id: cord-000425-isw6jeir author: Flori, Laurence title: Immunity Traits in Pigs: Substantial Genetic Variation and Limited Covariation date: 2011-07-29 words: 7843 flesch: 40 summary: This cluster is representative of total cell number traits despite the eosinophil count (EOS) not being included. The estimation of phenotypic correlations (r r p ) with WOMBAT confirmed that the ITs are weakly correlated, except i) among a few cell count traits (WBC, LYM, MON, NEU), and ii) between cell count traits and a few leukocyte subsets (WBC, LYM, CD16 + CD2 + and keywords: adaptive; blood; cd16; cell; correlations; france; heritability; immunity; lps; pigs; production; response; subsets; total; traits cache: cord-000425-isw6jeir.txt plain text: cord-000425-isw6jeir.txt item: #43 of 672 id: cord-000434-ff2zadol author: Zhao, Rongmao title: Identification of a Highly Conserved H1 Subtype-Specific Epitope with Diagnostic Potential in the Hemagglutinin Protein of Influenza A Virus date: 2011-08-19 words: 5789 flesch: 46 summary: The structure and function of the hemagglutinin membrane glycoprotein of influenza virus Influenza vaccines for the future Characterization of a novel influenza hemagglutinin, H15: criteria for determination of influenza A subtypes Manual of Diagnostic Tests and Vaccines for Terrestrial Animals Development of blocking ELISA for detection of antibodies against avian influenza virus of the H7 subtype Development of epitope-blocking ELISA for universal detection of antibodies to human H5N1 influenza viruses A laboratory manual for the isolation and identification of avian pathogens Comparison of the hemagglutination-inhibiting and neutralizing antibody responses of volunteers given 400 chick cellagglutinating units of influenza A/New Jersey/76 split-virus vaccine Role of the laboratory in diagnosis of influenza during seasonal epidemics and potential pandemics Development of rHA1-ELISA for specific and sensitive detection of H9 subtype influenza virus Prokaryotic expression and purification of HA1 and HA2 polypeptides for serological analysis of the 2009 pandemic H1N1 influenza virus Utility of pandemic H1N1 2009 influenza virus recombinant hemagglutinin protein-based enzymelinked immunosorbent assay for serosurveillance Ab and T cell epitopes of influenza A virus, knowledge and opportunities Epitope analysis for influenza vaccine design Quantifying influenza vaccine efficacy and antigenic distance Antigenic characterization of recombinant hemagglutinin proteins derived from different avian influenza virus subtypes Epitope mapping of the hemagglutinin molecule of a highly pathogenic H5N1 influenza virus by using monoclonal antibodies Evaluation of the subtype specificity of monoclonal antibodies raised against H1 and H3 subtypes of human influenza A virus hemagglutinins Establishment of retroviral pseudotypes with influenza hemagglutinins from H1, H3, and H5 subtypes for sensitive and specific detection of neutralizing antibodies Minimum requirements for immunogenic and antigenic activities of homologs of a synthetic peptide of influenza virus hemagglutinin Genetic control and fine specificity of the immune response to a synthetic peptide of influenza virus hemagglutinin Microneutralizing test is an alternative method to type and subtype influenza viruses. keywords: antibodies; antibody; elisa; epitopes; fig; iav; influenza; p31; peptides; subtype; virus cache: cord-000434-ff2zadol.txt plain text: cord-000434-ff2zadol.txt item: #44 of 672 id: cord-000460-h3owwjao author: Xiong, Jing title: Leukocyte- and Platelet-Derived Microvesicle Interactions following In Vitro and In Vivo Activation of Toll-Like Receptor 4 by Lipopolysaccharide date: 2011-09-26 words: 4328 flesch: 34 summary: While those experiments provide evidence that LPS modulates platelet activation, they do not provide any insight about the interactions of platelet with other blood elements within the earliest stages of activation especially at time points prior to the period when measurable changes in circulating cytokines are observed in vivo For example, MV derived from neutrophils induced platelet activation by binding to platelets GP1ba (Glycoprotein 1b a) via activated a M b 2 on MV [38] , while platelet-derived MV mediate leukocyte-leukocyte aggregation, activate leukocyte phagocytic properties and amplify leukocyte-mediated tissue injury in thrombotic and inflammatory disorders [39] . keywords: activation; antigen; blood; cell; leukocyte; lps; mice; platelet; tlr4 cache: cord-000460-h3owwjao.txt plain text: cord-000460-h3owwjao.txt item: #45 of 672 id: cord-000478-88wo4xen author: Gowen, Brian B. title: Use of Recombinant Adenovirus Vectored Consensus IFN-α to Avert Severe Arenavirus Infection date: 2011-10-24 words: 4418 flesch: 43 summary: *P,0.05, ***P,0.001 compared to rAd EV-treated animals Treatment of Bolivian hemorrhagic fever with intravenous ribavirin Interferon-alpha as an immunotherapeutic protein Interferon alfacon-1 protects hamsters from lethal pichinde virus infection Combinatorial ribavirin and interferon alfacon-1 therapy of acute arenaviral disease in hamsters Animal models of highly pathogenic RNA viral infections: hemorrhagic fever viruses Enhanced circulating half-life and antitumor activity of a site-specific pegylated interferonalpha protein therapeutic Treatment of Yellow Fever Virus with an Adenovirus-Vectored Interferon, DEF201, in a Hamster Model Pre-and post-exposure protection against Western equine encephalitis virus after single inoculation with adenovirus vector expressing interferon alpha Nasal delivery of an adenovirus-based vaccine bypasses pre-existing immunity to the vaccine carrier and improves the immune response in mice vitro and in vivo activities of T-705 against arenavirus and bunyavirus infections A simple method of estimating fifty percent endpoints Recognition of virus infection and innate host responses to viral gene therapy vectors Human macrophages, but not dendritic cells, are activated and produce alpha/beta interferons in response to Mopeia virus infection Differential inhibition of type I interferon induction by arenavirus nucleoproteins Short double-stranded RNAs with an overhanging 59 ppp-nucleotide, as found in arenavirus genomes, act as RIG-I decoys Z proteins of New World arenaviruses bind RIG-I and interfere with type I interferon induction Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus Early and strong immune responses are associated with control of viral replication and recovery in lassa virus-infected cynomolgus monkeys Type 1 interferons and the virus-host relationship: a lesson in detente Singledose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model Alpha interferon as an adenovirus-vectored vaccine adjuvant and antiviral in Venezuelan equine encephalitis virus infection Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and D Efficacy waned when DEF201 treatment was delayed to 48 h postinfection. keywords: animals; challenge; day; def201; hamsters; infection; picv; rad; virus cache: cord-000478-88wo4xen.txt plain text: cord-000478-88wo4xen.txt item: #46 of 672 id: cord-000501-qz68gtd4 author: Greatorex, Jane S. title: Survival of Influenza A(H1N1) on Materials Found in Households: Implications for Infection Control date: 2011-11-22 words: 4319 flesch: 41 summary: Parker et al (1944) demonstrated improved survival of influenza viruses in the presence of human mucus [8] ; and in 1962, Buckland demonstrated experimentally that influenza virus was inactivated relatively quickly on glass, probably through desiccation Estimating household and community transmission parameters for influenza Statistical procedures for estimating the community probability of illness in family studies: rhinovirus and influenza Simulation studies of influenza epidemics: assessment of parameter estimation and sensitivity Using data on social contacts to estimate age-specific transmission parameters for respiratory-spread infectious agents Review of aerosol transmission of influenza A virus Transmission of Influenza A in human beings Influenza and related infection control issues Resistance of the Melbourne strain of influenza virus to desiccation Loss of infectivity on drying various viruses Survival of influenza-viruses on environmental surfaces Survival of influenza virus on banknotes Effectiveness of common household cleaning agents in reducing the viability of human influenza A(H1N1) Biophysical characterization of influenza virus subpopulations using field flow fractionation and multiangle light scattering: correlation of particle counts, size distribution and infectivity Genome packaging in influenza A virus Virus shedding and environmental deposition of novel A(H1N1) pandemic influenza virus: interim findings Mutational analysis of cis-acting RNA signals in segment 7 of influenza A virus Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathway Comparison of enzyme-linked immunosorbent assay, indirect immunofluorescence assay and virus isolation for detection of respiratory viruses in nasopharyngeal secretions Enhanced detection of infectious airborne influenza virus The occurrence of influenza A virus on household and day center fomites Respiratory viral RNA on toys in pediatric office waiting rooms Occurrence of bacteria and viruses on elementary classroom surfaces and the potential role of classroom hygiene in the spread of infectious diseases Influenza virus contamination of common household surfaces during the 2009 influenza A (H1N1) pandemic in Bangkok, Thailand: implications for contact transmission keywords: data; hours; influenza; pandemic; pr8; surfaces; survival; transmission; virus; viruses cache: cord-000501-qz68gtd4.txt plain text: cord-000501-qz68gtd4.txt item: #47 of 672 id: cord-000536-0mn1gbll author: Hu, Le-Le title: Predicting Biological Functions of Compounds Based on Chemical-Chemical Interactions date: 2011-12-29 words: 5173 flesch: 41 summary: In the downloaded STITCH chemicals interactions file: chemical_chemical.links.detailed.v2.0.tsv from http://stitch.embl.de/cgi/show_download_page.pl, there are 337,482 pairs of interactive compounds belonging solely to type I, 73,598 pairs solely in type II, 2,152,508 pairs solely in type III, 384 pairs in both type I and II, 120,936 pairs in both type I and III, 10,372 pairs in both type II and III, and 1,990 pairs in the three types, in total of 2,697,270 interactions. Here, we did not consider the selfinteraction, therefore w q,i~0 when q~i. Accordingly, the likelihood that the query compound C q is involved in the j-th metabolic pathway class can be formulated by the following score which is the sum of the interaction confidence scores of C q with its interactive compounds in the training dataset by counting both the number of interactive compounds and the interaction confidence scores. keywords: chemical; classes; compounds; interaction; metabolic; method; pathway; pathway classes; prediction cache: cord-000536-0mn1gbll.txt plain text: cord-000536-0mn1gbll.txt item: #48 of 672 id: cord-000539-uh3q65we author: Zhang, Yi title: Acute Respiratory Distress Syndrome Induced by a Swine 2009 H1N1 Variant in Mice date: 2012-01-03 words: 4631 flesch: 47 summary: The typical 2009 H1N1 virus, such as A/California/04/2009 (CA/04), can efficiently replicate in mouse lungs without prior host adaptation. Interferon (IFN)-c, monocyte chemotactic protein (MCP)-1, and tumor necrosis factor (TNF) dramatically increased in mouse lungs on days 6-8 p.i. keywords: ards; day; h1n1; infection; influenza; lung; mice; p.i; sd/09; virus cache: cord-000539-uh3q65we.txt plain text: cord-000539-uh3q65we.txt item: #49 of 672 id: cord-000540-bbjmcdo5 author: Hellard, Eléonore title: True versus False Parasite Interactions: A Robust Method to Take Risk Factors into Account and Its Application to Feline Viruses date: 2012-01-03 words: 7599 flesch: 39 summary: Patterns of co-ccurrence Interactions between species and the structure of helminth communities Detecting interspecific macroparasite interactions from ecological data: patterns and process Species Interactions in a Parasite Community Drive Infection Risk in a Wildlife Population Effects of bovine leucosis virus (BLV) infection on the bovine viral diarrhoea virus (BVDV) and bovine herpes virus 1 (BHV1) seroprevalences in dairy herds in Turkey Interactions between macroparasites and microparasites drive infection patterns in freeranging African buffalo Analysis of larval trematode communities Methods for estimation of associations between multiple species parasite infections Do the helminth parasites of wood mice interact Associations between filarial and gastrointestinal nematodes Possible interaction between myxomatosis and calicivirosis related to rabbit haemorrhagic disease affecting the European rabbit Spacing pattern in a population of rural free roaming domestic cats The mating system of feral cats (Felis catus L.) in a sub-Antarctic environment Retroviruses and sexual size dimorphism in domestic cats Bold attitude makes male urban feral domestic cats more vulnerable to Feline Immunodeficiency Virus When cats' ways of life interact with their viruses: a study in 15 natural populations of owned and unowned cats (Felis silvestris catus) The Large-Sample Distribution of the Likelihood Ratio for Testing Composite Hypotheses Feline immunodeficiency virus: an epidemiologic review A Serologic survey of wild felids from Central West Saudi Arabia Seroprevalence and genomic divergence of circulating strains of Feline Immunodeficiency Virus among Felidae and Hyaenidae species Current thoughts on feline immunodeficiency virus infection Feline immunodeficiency virus: an interesting model for AIDS studies and an important cat pathogen Feline calicivirus infection: ABCD guidelines on prevention and management Feline herpesvirus infection: ABCD guidelines on prevention and management Observations on the epidemiology and control of viral respiratory disease in cats Transmission of feline viral rhinotracheitis Experimental induction of feline rhinotracheitis virus re-excretion in FVR-recovered cats Parvovirus infections in wild carnivores Feline panleukopenia ABCD guidelines on prevention and management Immune carrier state of feline panleukopenia virus-infected cats Seasonality, mortality and herd immunity in feline panleukopenia Dynamics of a feline virus with two transmission modes within exponentially growing host populations Using Dynamic Stochastic Modelling to Estimate Population Risk Factors in Infectious Disease: The Example of FIV in 15 Cat Populations Alternative early life vaccination programs for companion animals AIC model selection in overdispersed capture-recapture data Innate immunity of the newborn: basic mechanisms and clinical correlates Age-related differences in social grooming among adult female Japanese monkeys (Macaca fuscata) FIV infection of the domestic cat: An animal model for AIDS Effect of primary stage feline immunodeficiency virus infection on subsequent feline calicivirus vaccination and challenge in cats Effects of incidental infections and immune activation on disease progression in experimentally feline immunodeficiency virus-infected cats Chronic oral infections of cats and their relationship to persistent oral carriage of feline calici-, immunodeficiency, or leukemia viruses Interaction of acute feline herpesvirus-1 and chronic feline immunodeficiency virus infections in experimentally infected specific pathogen free cats Activation of feline immunodeficiency virus long terminal repeat by feline herpesvirus type 1 Herpes simplex virus type-1 can reactivate transcription of latent human immunodeficiency virus The Herpes-simplex Virus Immediate-early Protein, Icp4, Is Required To Potentiate Replication of Human Immunodeficiency Virus In Cd4+ Lymphocytes Activation of Human-immunodeficiency-virus By Herpes-simplex Virus Co-infection and synergy of human immunodeficiency virus-1 and herpes simplex virus-1 Prevalence Of Feline Calicivirus, Feline Leukemia-Virus And Antibodies To FIV In Cats With Chronic Stomatitis Virus infections of carnivores Apoptosis in feline panleukopenia virus-infected lymphocytes Use of a feline panleukopenia modified live virus vaccine in cats in the primary-stage of feline immunodeficiency virus infection Long-term immunity in cats vaccinated with an inactivated trivalent vaccine Prevalence of antibodies to feline parvovirus, calicivirus, herpesvirus, coronavirus, and immunodeficiency virus and of feline leukemia virus antigen and the interrelationship of these viral infections in free-ranging lions in east Africa Genetic determinants of HIV-1 infection and progression to AIDS: immune response genes Host genetics in African trypanosomiasis Genetic dissection of host resistance to Mycobacterium tuberculosis: the sst1 locus and the Ipr1 gene Bovine tuberculosis: the genetic basis of host susceptibility Parasites, bright males, and the immunocompetence handicap Host condition and individual risk of cowpox virus infection in natural animal populations: cause or effect? Worms can worsen malaria: towards a new means to roll back malaria? Malaria and helminth interactions in humans: an epidemiological viewpoint The role of positive and negative interspecific associations in the organization of communities of intestinal helminths of bats Spatial niche competition among helminth parasites in horse's large intestine Intestinal Helminths Of Lesser Scaup Ducks -Patterns Of Association Host immunization shapes interspecific associations in trematode parasites Interspecific interactions tested -2 species of malarial parasite in a west-african lizard Prior bovine immunodeficiency virus infection does not inhibit subsequent superinfection by the acutely pathogenic Jembrana disease virus Immunologic responses to Vibrio cholerae in patients co-infected with intestinal parasites in Bangladesh When domestic cat (Felis silvestris catus) population structures interact with their viruses Trichinella spiralis: delayed rejection in mice concurrently infected with Nematospiroides dubius Crossimmunity between Haemonchus contortus and Trichostrongylus colubriformis in sheep Evidence of interaction between Ascaris suum and Metastrongylus apri in experimentally infected pigs Community structure: larval trematodes in snail hosts Analysis of larval trematode communities Analysing interspecific associations in parasites: alternative methods and effects of sampling heterogeneity Do the helminth parasites of wood mice interact? keywords: chi; data; factors; feline; fhv; fiv; infection; interactions; regression; risk; square; virus; viruses cache: cord-000540-bbjmcdo5.txt plain text: cord-000540-bbjmcdo5.txt item: #50 of 672 id: cord-000547-adfigzc1 author: Beniac, Daniel R. title: The Organisation of Ebola Virus Reveals a Capacity for Extensive, Modular Polyploidy date: 2012-01-11 words: 7821 flesch: 47 summary: (MOV) Physical principles in the construction of regular viruses Studies on the pleomorphism of HVJ virons Infectious bursal disease virus is an icosahedral polyploid dsRNA virus Architecture of ribonucleoprotein complexes in influenza A virus particles Ebola virus: new insights into disease aetiopathology and possible therapeutic interventions Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses Ebola virus: from discovery to vaccine The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing GP mRNA of Ebola virus is edited by the Ebola virus polymerase and by T7 and vaccinia virus polymerases Ebola virus glycoprotein 1: identification of residues important for binding and postbinding events Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor Comprehensive analysis of ebola virus GP1 in viral entry Identification of two amino acid residues on Ebola virus glycoprotein 1 critical for cell entry The assembly of Ebola virus nucleocapsid requires virion-associated proteins 35 and 24 and posttranslational modification of nucleoprotein Functional mapping of the nucleoprotein of Ebola virus Nucleocapsid-like structures of Ebola virus reconstructed using electron tomography Electron tomography reveals the steps in filovirus budding GraFix: stabilization of fragile macromolecular complexes for single particle cryo-EM GraFix: sample preparation for single-particle electron cryomicroscopy Post-crystallization treatments for improving diffraction quality of protein crystals Differentiation of filoviruses by electron microscopy Ebola and Marburg viruses: I. Some ultrastructural differences between strains when grown in Vero cells Ultrastructure of Ebola virus particles in human liver On the etiology of an unknown human infection originating from monkeys Apoptosis induced in vitro and in vivo during infection by Ebola and Marburg viruses Movie S1 3-D reconstruction of Ebola virus nucleocapsid. keywords: analysis; cryo; ebola; ebola virus; ebov; figure; genome; image; length; nucleocapsid; particles; protein; structure; virus; vp40 cache: cord-000547-adfigzc1.txt plain text: cord-000547-adfigzc1.txt item: #51 of 672 id: cord-000554-p4ufea6x author: Gao, Wei title: Distinct Regulation of Host Responses by ERK and JNK MAP Kinases in Swine Macrophages Infected with Pandemic (H1N1) 2009 Influenza Virus date: 2012-01-18 words: 5545 flesch: 47 summary: World Health Organization Swine influenza H1N1 virus induces acute inflammatory immune responses in pig lungs: a potential animal model for human H1N1 influenza virus Cytokines and acute phase proteins associated with acute swine influenza infection in pigs Porcine innate and adaptative immune responses to influenza and coronavirus infections Cytokines in the pathogenesis of influenza Alveolar macrophages are indispensable for controlling influenza viruses in lungs of pigs Pathology of the swine-origin influenza A (H1N1) flu Replication and plaque assay of influenza virus in an established line of canine kidney cells Immune-related gene expression in response to H11N9 low pathogenic avian influenza virus infection in chicken and Pekin duck peripheral blood mononuclear cells Modulation of the immune responses in chickens by low-pathogenicity avian influenza virus H9N2 Genetic and phenotypic characterization of a low-pathogenicity avian influenza H11N9 virus Host immune and apoptotic responses to avian influenza virus H9N2 in human tracheobronchial epithelial cells RNA recognition and signal transduction by RIG-I-like receptors RIG-I-like receptors: sensing and responding to RNA virus infection Pandemic H1N1 2009 influenza Previous studies found that IFN induction was dependent on the JNK1/2 signaling pathway in epithelial cells infected with influenza virus infection keywords: cells; erk1/2; h1n1pdm; induction; infection; influenza; jnk1/2; macrophages; swine; virus cache: cord-000554-p4ufea6x.txt plain text: cord-000554-p4ufea6x.txt item: #52 of 672 id: cord-000556-uu1oz2ei author: Kumar, Ranjit title: RNA-Seq Based Transcriptional Map of Bovine Respiratory Disease Pathogen “Histophilus somni 2336” date: 2012-01-20 words: 4410 flesch: 43 summary: We identified co-expression for 452 pairs (total 730 genes) of H. somni genes ( Table S2 ) that were transcribed together and constituted a minimal operon. Regions where coverage depth was greater than the lower tenth percentile of expressed genes were considered significantly expressed [21] ; in the current study, this corresponded to a coverage depth of 7 reads/bp in pileup format. keywords: coding; genes; genome; novel; protein; regions; rna; seq; somni; srnas; transcriptome cache: cord-000556-uu1oz2ei.txt plain text: cord-000556-uu1oz2ei.txt item: #53 of 672 id: cord-000574-7eflwyxk author: Liu, Yanli title: Effects of a Non-Conservative Sequence on the Properties of β-glucuronidase from Aspergillus terreus Li-20 date: 2012-02-07 words: 3932 flesch: 43 summary: Furthermore, Km of AtGUS(-3t)-E (1.95 mM) was just nearly one-seventh that of AtGUS-E (12.9 mM), whereas the catalytic efficiency of AtGUS(-3t)-E was 3.2 fold higher than that of AtGUS-E (7.16 vs. 2.24 mM s(−1)), revealing that the truncation of non-conservative sequence can significantly improve the catalytic efficiency of AtGUS. These results suggest that the secondary structure of AtGUS-E has changed after deletion of non-conservative sequence. keywords: activity; atgus; domain; enzyme; sequence cache: cord-000574-7eflwyxk.txt plain text: cord-000574-7eflwyxk.txt item: #54 of 672 id: cord-000580-dcid9emx author: Sällman Almén, Markus title: The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human Members date: 2012-02-20 words: 4665 flesch: 44 summary: The DSPA/IFITM subfamily is the most numerous and the mouse and human genes are all clustered in a consecutive manner on chromosome six and eleven, respectively. Establishing a rigid nomenclature based on evolutionary information and structural features of the predicted proteins facilitates prediction of the functional role of these genes that often have only have been studied in large gene or transcription consortia. keywords: analysis; dispanins; family; figure; genes; human; ifitm; proteins; sequences; subfamilies; subfamily cache: cord-000580-dcid9emx.txt plain text: cord-000580-dcid9emx.txt item: #55 of 672 id: cord-000581-ewx5xhrb author: Rudge, James W. title: Health System Resource Gaps and Associated Mortality from Pandemic Influenza across Six Asian Territories date: 2012-02-21 words: 5721 flesch: 30 summary: Figure 1 presents the geographical distribution of estimated resource gaps across provinces (or districts in the case of Indonesia) in each study country for the modeled pandemic influenza scenario, under our baseline assumptions and point estimates for parameter values. We found particularly wide variation in the availability of ventilators, and indeed other hospital resources, in Thailand, where our results suggest that inequitable distribution of health system resources [32] , rather than simply an overall nationwide shortage, could lead to a high number of avoidable deaths from pandemic influenza. keywords: countries; deaths; gaps; health; influenza; pandemic; provinces; resource; ventilators cache: cord-000581-ewx5xhrb.txt plain text: cord-000581-ewx5xhrb.txt item: #56 of 672 id: cord-000588-3wok0n21 author: Sainz, Juan title: Dectin-1 and DC-SIGN Polymorphisms Associated with Invasive Pulmonary Aspergillosis Infection date: 2012-02-27 words: 5519 flesch: 34 summary: By the inclusion of functional prediction analyses, the correlation of genotypes with positive GM determinations and Dectin-1 mRNA expression levels, the study strongly supported the role of Dectin-1 gene variants in determining susceptibility to IPA infection. Our predictive analysis showed that the carriage of the C allele for the Dectin-1 rs7309123 SNP creates a putative binding site for Cdxa, a relatively unknown transcription factor, which might be involved in the control of Dectin-1 gene expression. keywords: aspergillosis; ccl2; cell; dectin-1; gene; infection; ipa; patients; polymorphisms; risk; sign; snps; susceptibility; type cache: cord-000588-3wok0n21.txt plain text: cord-000588-3wok0n21.txt item: #57 of 672 id: cord-000609-dpcgl6ig author: Raju, Sammeta V. title: Suppression of Adenosine-Activated Chloride Transport by Ethanol in Airway Epithelia date: 2012-03-19 words: 4091 flesch: 38 summary: Adenosine receptors, cystic fibrosis, and airway hydration Cystic fibrosis Ethanol stimulates ciliary beating by dual cyclic nucleotide kinase activation in bovine bronchial epithelial cells Ethanol increases phosphodiesterase 4 activity in bovine bronchial epithelial cells Ethanol Upregulates Glucocorticoid-Induced Leucine Zipper Expression and Modulates Cellular Inflammatory Responses in Lung Epithelial Cells Isolation of CF cell lines corrected at DeltaF508-CFTR locus by SFHR-mediated targeting Influence of cell polarity on retrovirus-mediated gene transfer to differentiated human airway epithelia Human coronavirus 229E infects polarized airway epithelia from the apical surface Adenosine receptors and phosphodiesterase inhibitors stimulate Cl-secretion in Calu-3 cells Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium Soluble mediators, not cilia, determine airway surface liquid volume in normal and cystic fibrosis superficial airway epithelia Predominant constitutive CFTR conductance in small airways Purinergic regulation of epithelial transport Interferon-gamma down-regulates adenosine 2b receptor-mediated signaling and short circuit current in the intestinal epithelia by inhibiting the expression of adenylate cyclase Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity Modelling mucociliary clearance Innate immune functions of the airway epithelium Macrophages and polymorphonuclear neutrophils in lung defense and injury These data altogether confirmed that in airway epithelial cells ethanolsuppression of chloride transport is mediated through CFTR, a cAMP-activated chloride channel. keywords: adenosine; airway; camp; cells; cftr; chloride; epithelial; ethanol; transport cache: cord-000609-dpcgl6ig.txt plain text: cord-000609-dpcgl6ig.txt item: #58 of 672 id: cord-000638-ss1435el author: Beq, Stephanie title: Altered Thymic Function during Interferon Therapy in HCV-Infected Patients date: 2012-04-16 words: 5154 flesch: 37 summary: HIV-Hepatitis Spanish Study Group Future trends in managing hepatitis C Treatment of hepatitis C and anemia in human immunodeficiency virus-infected patients Use of pegylated interferons is associated with an increased incidence of infections during combination treatment of chronic hepatitis C: a side effect of pegylation? Incidence of neutropenia and infections during combination treatment of chronic hepatitis C with pegylated interferon alfa-2a or alfa-2b plus ribavirin Opportunistic infections and CD4 lymphocytopenia with interferon treatment in HIV-1 infected patients Regulation of cytokine expression by interferon-alpha in human bone marrow stromal cells: inhibition of hematopoietic growth factors and induction of interleukin-1 receptor antagonist Effects of recombinant alpha and gamma interferons on the in vitro growth of circulating hematopoietic progenitor cells (CFU-GEMM, CFU-Mk, BFU-E, and CFU-GM) from patients with myelofibrosis with myeloid metaplasia Impairment of T and B cell development by treatment with a type I interferon CD4+ T-lymphocytopenia in HIV-infected patients receiving interferon therapy for chronic hepatitis C. HIV-Hepatitis Spanish Study Group Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation Changes in thymic function with age and during the treatment of HIV infection Slow disease progression and robust therapy-mediated CD4+ T-cell recovery are associated with efficient thymopoiesis during HIV-1 infection IL-7 induces immunological improvement in SIV-infected rhesus macaques under antiviral therapy T cell homeostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors The magnitude of thymic output is genetically determined through controlled intrathymic precursor T cell proliferation Estimating thymic function through quantification of T-cell receptor excision circles Interleukin-7 treatment counteracts IFN-{alpha} therapy-induced lymphopenia and stimulates SIV-specific cytotoxic T lymphocyte responses in SIV-infected rhesus macaques Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1) The role of interleukin-7 in early T-cell development A direct estimate of the human alphabeta T cell receptor diversity How cells respond to interferons Augmentation of antitumor activity of 5-fluorouracil by interferon alpha is associated with up-regulation of p27Kip1 in human hepatocellular carcinoma cells Down-regulation of p27Kip1 expression is required for development and function of T cells Endogenous interferon-alpha production by differentiating human monocytes regulates expression and function of the IL-2/IL-4 receptor gamma chain Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood Tlymphocyte populations in hepatitis C and HIV co-infected patients treated with interferon-alfa-2a and ribavirin Interferon alpha augments activation-induced T cell death by upregulation of Fas (CD95/APO-1) and Fas ligand expression IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis Rapid decline of CD4+ cells after IFN alpha treatment in HIV-1 infection Injection of glycosylated recombinant simian IL-7 provokes rapid and massive T-cell homing in rhesus macaques Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells Hepatic interleukin-7 expression regulates T cell responses Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistence Interleukin-7 receptor expression: intelligent design Hepatitis C virus (HCV) genotype 1 subtype identification in new HCV drug development and future clinical practice Determinants of antiviral treatment initiation in a hepatitis C-infected population benefiting from universal health care coverage Response rates to pegylated interferon and ribavirin in HCV/HIV coinfection: a research synthesis Rare birds in North America: acute hepatitis C cohorts A validated assay to measure soluble IL-7 receptor shows minimal impact of IL-7 treatment The authors acknowledge the subjects who participated in this study. keywords: cell; figure; hcv; hiv; ifna; il-7; patients; plasma; proliferation; therapy cache: cord-000638-ss1435el.txt plain text: cord-000638-ss1435el.txt item: #59 of 672 id: cord-000642-mkwpuav6 author: Moreira, Rebeca title: Transcriptomics of In Vitro Immune-Stimulated Hemocytes from the Manila Clam Ruditapes philippinarum Using High-Throughput Sequencing date: 2012-04-19 words: 6864 flesch: 41 summary: Hits to R. philippinarum sequences were represented in a Venn diagram. The discovery of new immune sequences was very productive and resulted in a large variety of contigs that may play a role in the defense mechanisms of Ruditapes philippinarum. keywords: analysis; bivalves; clam; contigs; expression; factor; genes; immune; philippinarum; proteins; recognition; response; ruditapes; sequences; species; transcriptome cache: cord-000642-mkwpuav6.txt plain text: cord-000642-mkwpuav6.txt item: #60 of 672 id: cord-000666-je9t4i6q author: Verbist, Katherine C. title: IL-15 Participates in the Respiratory Innate Immune Response to Influenza Virus Infection date: 2012-05-18 words: 7242 flesch: 40 summary: Nevertheless, we wished to test whether the large increases in NK cell number in the lung airways following IL-15c administration could be attributed to IL-15-induced proliferation of NK cells at the site. In contrast, CD122 signaling appears to be important for NK cell migration to IL-15 as this receptor chain is down regulated on NK cells exposed to IL-15c in vivo ( Figure 3 ). keywords: airways; animals; cd8; cells; day; expression; figure; il-15; infection; influenza; lung; p.i cache: cord-000666-je9t4i6q.txt plain text: cord-000666-je9t4i6q.txt item: #61 of 672 id: cord-000689-8lvzab4i author: Qi, Yilin title: The Acute Environment, Rather than T Cell Subset Pre-Commitment, Regulates Expression of the Human T Cell Cytokine Amphiregulin date: 2012-06-14 words: 6566 flesch: 47 summary: We next tested whether human CD4 T cells expressed AR during antigen/APC stimulation in response to influenza peptides, allergens or tetanus antigens to stimulate Type 1, Type 2 and Thpp-biased recall responses, respectively [6] . Additional surface markers, including CD27 and the homing receptor CD62L are also expressed heterogeneously on human CD4 T cells. keywords: anti; camp; cd4; cells; cytokine; expression; figure; human; production; th1; th2 cache: cord-000689-8lvzab4i.txt plain text: cord-000689-8lvzab4i.txt item: #62 of 672 id: cord-000695-g5sum116 author: Hou, Yanxia title: Prediction and Identification of T Cell Epitopes in the H5N1 Influenza Virus Nucleoprotein in Chicken date: 2012-06-20 words: 5347 flesch: 52 summary: First, this is the first study to determine the structural characteristics of the peptide-binding domains of chicken MHC class I molecules belonging to the B4, B12, B15, and B19 haplotypes using a combined motif-structure method to predict T cell epitopes in chickens. The results indicate that peptides NP(89–97) (PKKTGGPIY) and NP(198–206) (KRGINDRNF) are NP T cell epitopes in chicken of certain haplotypes. keywords: b19; binding; cell; chicken; class; epitopes; haplotypes; mhc; molecules; peptide; t cell cache: cord-000695-g5sum116.txt plain text: cord-000695-g5sum116.txt item: #63 of 672 id: cord-000715-zl1s82yi author: Shulman, Lester M. title: Evaluation of Four Different Systems for Extraction of RNA from Stool Suspensions Using MS-2 Coliphage as an Exogenous Control for RT-PCR Inhibition date: 2012-07-16 words: 4791 flesch: 42 summary: The number of stool suspension RNA extracts with inhibitors of MS2 rRT-PCR varied between RNA extraction protocols for randomly chosen stool suspensions. Potential inhibitors that might be incompletely removed from stool suspensions during RNA extraction include hemoglobin, immunoglobulins, bilirubin, triglycerides, complex polysaccharides, organic and phenolic compounds, glycogen, fats, and metabolic products especially those from pathological conditions, bacteria, vegetables, medications, anticoagulants, and drugs or alcohol keywords: extraction; inhibition; inhibitors; ms2; pcr; rna; rrt; samples; stool cache: cord-000715-zl1s82yi.txt plain text: cord-000715-zl1s82yi.txt item: #64 of 672 id: cord-000719-o7ttiu97 author: Jonsson, Colleen B. title: Molecular Imaging Reveals a Progressive Pulmonary Inflammation in Lower Airways in Ferrets Infected with 2009 H1N1 Pandemic Influenza Virus date: 2012-07-20 words: 6413 flesch: 43 summary: These results suggest that molecular imaging will be a great asset in gaining insight into the temporal and spatial progression of the inflammatory process caused by influenza virus infection. To explore the potential utility of molecular imaging in influenza infection, we chose the ferret (Mustela putorius furo) model. keywords: caudal; day; ferrets; h1n1; h1n1pdm; imaging; infection; influenza; lobe; lung; pandemic; pet; right; virus cache: cord-000719-o7ttiu97.txt plain text: cord-000719-o7ttiu97.txt item: #65 of 672 id: cord-000720-5b936n3g author: Nannyonga, Betty title: The Dynamics, Causes and Possible Prevention of Hepatitis E Outbreaks date: 2012-07-24 words: 4408 flesch: 53 summary: [11] t Outbreak of chicken flu rattles Hong Kong Transmission dynamics and control of severe acute respiratory syndrome The Epidemiology and Control of Malaria A contribution to the mathematical theory of epidemics Inapparent infections and cholera dynamics Impact of immunisation on pertussis transmission in England and Wales Ministry of Health Uganda Weekly Report Mathematical Approaches for Emerging and Re emerging Infectious Diseases: An Introduction The global emergence/resurgence of arboviral diseases as public health problems Emerging infectious diseases: A global fire brigade responds to disease outbreaks Temporal association of acute Hepatitis A and Plasmodium falciparum malaria in children Association of hepatitis B surface antigen carriage with severe malaria in Gambian children Short Report: Hepatitis B infection and severe Plasmodium falciparum in Vietnamese adults Hepatitis B Infection Is Associated with Asymptomatic Malaria in the Brazilian Amazon HostVirus Interactions during Malaria Infection in Hepatitis B Virus Transgenic Mice Lastly, we further investigate the relationship between the co-infection factor for malaria and Hepatitis E on the value of [Image: see text] for Hepatitis E. Taken together, these results provide us with a better understanding of the dynamics and possible causes of Hepatitis E outbreaks. keywords: disease; dynamics; hepatitis; infection; malaria; model; number; outbreak; population cache: cord-000720-5b936n3g.txt plain text: cord-000720-5b936n3g.txt item: #66 of 672 id: cord-000721-leedutqo author: Nawaz, Sameena title: Human Bocaviruses Are Not Significantly Associated with Gastroenteritis: Results of Retesting Archive DNA from a Case Control Study in the UK date: 2012-07-24 words: 3207 flesch: 40 summary: HBoV infections were detected year round although a peak was observed in the spring/early summer months, between April and June 1994 (Figure 2 ). The prevalence of HBoV infection in the UK population was found to be 7.4% across all ages, with a higher percentage of the infections occurring in children ,5 years of age (19%). keywords: cases; children; controls; hbov; samples; study cache: cord-000721-leedutqo.txt plain text: cord-000721-leedutqo.txt item: #67 of 672 id: cord-000723-wo20st5w author: Xu, Zhenqiang title: Molecular and Microscopic Analysis of Bacteria and Viruses in Exhaled Breath Collected Using a Simple Impaction and Condensing Method date: 2012-07-25 words: 5057 flesch: 45 summary: Sphingomonas paucimobilis and Kocuria variants were found dominant in EBC samples using VITEK 2 system. Typically, these devices would be able to collect 1000 ml of EBC samples within about 10 min, however the collection often comes with a lengthy procedure and a higher cost. keywords: breath; collection; device; ebc; figure; hydrophobic; method; particles; samples; subjects; viruses cache: cord-000723-wo20st5w.txt plain text: cord-000723-wo20st5w.txt item: #68 of 672 id: cord-000725-rafwlw0t author: Hindinger, Claudia title: IFN-γ Signaling to Astrocytes Protects from Autoimmune Mediated Neurological Disability date: 2012-07-27 words: 5125 flesch: 35 summary: Supporting an initial pro-inflammatory role of astrocytes dependent on innate, not IFN-c responsiveness, inhibition of IFN-c signaling to astrocytes did not influence EAE onset or incidence, initial disease progression, astrocyte activation, or BBB integrity as indicated by similar entry of inflammatory cells into the brain. Therefore, astrocyte activation constitutes a ubiquitous, yet heteroge-neous response associated with both promoting and inhibiting CNS repair [3] [4] [5] . keywords: activation; astrocytes; cells; cns; disease; fig; gfapcr1d; ifn; mice; signaling cache: cord-000725-rafwlw0t.txt plain text: cord-000725-rafwlw0t.txt item: #69 of 672 id: cord-000726-tonaaft2 author: Chang, Binggong title: Influence of Mabs on PrP(Sc) Formation Using In Vitro and Cell-Free Systems date: 2012-07-27 words: 4988 flesch: 45 summary: It is interesting to note that, with the exception of only 8E9, the epitopes for all the Mabs that caused complete inhibition are located in the amino half of the PrP while those that caused incomplete inhibition are located in the carboxy half of PrP. There was good correlation between the extent of PrP Sc inhibition when 10 mg/ml Mab in cell culture was compared to 12 mg/ml Mab with sPMCA 40 . The PrP-specific Mabs that were evaluated for their ability to prevent PrP C to PrP Sc conversion have linear epitopes that span the entire prion protein from the amino to the carboxy terminus ( Table 1 , Fig. 1 ). keywords: antibodies; cells; conversion; formation; inhibition; mabs; prion; protein; prp cache: cord-000726-tonaaft2.txt plain text: cord-000726-tonaaft2.txt item: #70 of 672 id: cord-000736-6f8vyziv author: Pripuzova, Natalia title: Development of Real-Time PCR Array for Simultaneous Detection of Eight Human Blood-Borne Viral Pathogens date: 2012-08-17 words: 6827 flesch: 47 summary: The results of sensitivity testing of the real-time PCR array primer sets specific for HIV-1, HIV-2, HBV, HCV, and WNV the with FDA/CBER analytical plasma panels. Example of the experimental testing of HIV-1 specific primer set targeting gag gene (NP3/4) for its sensitivity with DNA analytical standards is shown in Figure S1 . keywords: array; copies; dna; hiv-1; human; pcr; plasma; primer; samples; sets; specific; virus cache: cord-000736-6f8vyziv.txt plain text: cord-000736-6f8vyziv.txt item: #71 of 672 id: cord-000742-0r4z1zea author: Vittecoq, Marion title: High Influenza A Virus Infection Rates in Mallards Bred for Hunting in the Camargue, South of France date: 2012-08-27 words: 5927 flesch: 48 summary: For this reason, avian influenza viruses (AIV) have been studied since 2004 in the area. 26/06/2006 | Ministe Áre de l'Alimentation, de l'Agriculture et de la Pe Ãche Efficacy of Oseltamivir-Zanamivir Combination Compared to Each Monotherapy for Seasonal Influenza: A Randomized Placebo-Controlled Trial Universal primer set for amplification and sequencing of HA0 cleavage sites of all influenza A viruses Assessment of methods for amino acid matrix selection and their use on empirical data shows that ad hoc assumptions for choice of matrix are not justified Differential effect of nucleotide substitutions in the 39arm of the influenza A virus vRNA promoter on transcription/replication by avian and human polymerase complexes is related to the nature of PB2 amino acid 627 Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential Avian influenza keywords: aiv; avian; birds; camargue; ducks; h10n7; hand; influenza; mallards; strain; virus; viruses; wild cache: cord-000742-0r4z1zea.txt plain text: cord-000742-0r4z1zea.txt item: #72 of 672 id: cord-000765-r7y1cqou author: Chang, Yu-Ming title: Functional Studies of ssDNA Binding Ability of MarR Family Protein TcaR from Staphylococcus epidermidis date: 2012-09-21 words: 5795 flesch: 46 summary: Moreover, to investigate possible pH effect of ssDNA binding activity of TcaR, a series of buffers with increasing pH were tested for their potential interfere in TcaR-ssDNA binding. In contrast, such ssDNA binding properties were not observed for other MarR family protein and TetR family protein, suggesting that the results from our studies are not an artifact due to simple charge interactions between TcaR and ssDNA. keywords: ability; antibiotics; binding; family; figure; gc33; icar; interaction; marr; protein; resistance; ssdna; tcar cache: cord-000765-r7y1cqou.txt plain text: cord-000765-r7y1cqou.txt item: #73 of 672 id: cord-000786-ofpcgxce author: Chua, Brendon Y. title: Hepatitis C VLPs Delivered to Dendritic Cells by a TLR2 Targeting Lipopeptide Results in Enhanced Antibody and Cell-Mediated Responses date: 2012-10-16 words: 6418 flesch: 37 summary: This result also correlated with significantly higher numbers of specific antibody secreting cells that was detected in the spleens of VLP+E(8)Pam(2)Cys vaccinated mice and greater ability of sera from these mice to neutralise the binding and uptake of VLPs by Huh7 cells. For the detection of specific antibody secreting cells by ELISPOT, PVDF membrane-lined 96-well plates (Mabtech, Nacka Strand, Sweden) were coated with 100 ml of PBS containing VLPs (10 mg/ml), recombinant E2 (10 mg/ml) or anti IgG antibody (10 mg/ml) overnight at 4uC. Plates were washed 5 times with PBS and blocked for 2 hours using RPMI 1640 medium (Gibco, USA) supplemented with 20% BSA (Sigma, Australia). keywords: antibody; cells; cys; hcv; hepatitis; mice; pam; responses; usa; virus; vlps cache: cord-000786-ofpcgxce.txt plain text: cord-000786-ofpcgxce.txt item: #74 of 672 id: cord-000809-9voqa1oy author: Archer, Brett N. title: Reproductive Number and Serial Interval of the First Wave of Influenza A(H1N1)pdm09 Virus in South Africa date: 2012-11-16 words: 3885 flesch: 43 summary: A preliminary estimation of the reproduction ratio for new influenza A(H1N1) from the outbreak in Mexico Introduction of 2009 pandemic influenza A(H1N1) into South Africa: Clinical presentation, epidemiology and transmissibility of the first 100 cases Interim report on pandemic H1N1 influenza virus infections in South Africa CDC protocol of realtime RTPCR for swine influenza A(H1N1), revision 1 A likelihood-based method for real-time estimation of the serial interval and reproductive number of an epidemic Different epidemic curves for severe acute respiratory syndrome reveal similar impacts of control measures Statistical analysis with missing data Estimation of the serial interval of influenza Strategies for containing an emerging influenza pandemic in Southeast Asia Risk factors of influenza transmission in households The reproduction number of seasonal influenza epidemics in Brazil Seasonal influenza in the United States, France, and Australia: transmission and prospects for control Transmissibility of 1918 pandemic influenza Estimates of the reproduction numbers of Spanish influenza using morbidity data Transmissibility of the influenza virus in the 1918 pandemic Containing pandemic influenza with antiviral agents Potential impact of antiviral drug use during influenza pandemic Estimates of the transmissibility of the 1968 (Hong Kong) influenza pandemic: evidence of increased transmissibility between successive waves Reporting errors in infectious disease outbreaks, with an application to Pandemic Influenza A/H1N1 We would like to acknowledge and thank the many individuals and organisations who contributed to the investigation and response to pandemic influenza in South Africa, including the public-and privatesector laboratories that contributed data to the national central registry of confirmed cases. In this work we incorporate data collected on all laboratory-confirmed cases detected during the 2009 pH1N1 epidemic in South Africa with the aim of describing the transmissibility characteristics (initial R t and temporal variation of R t ) of the epidemic in the country and compare its dynamics with those observed in other countries in the same year. keywords: cases; influenza; method; pandemic cache: cord-000809-9voqa1oy.txt plain text: cord-000809-9voqa1oy.txt item: #75 of 672 id: cord-000813-gagakqw4 author: Xue, Mei title: Identification of a Conserved B-cell Epitope on Reticuloendotheliosis Virus Envelope Protein by Screening a Phage-displayed Random Peptide Library date: 2012-11-21 words: 4402 flesch: 45 summary: However, the epitope identified in REV gp90 protein has not been finely mapped, and the core sequence of the epitope needs to be determined. After being blocked with 5% skim milk in PBS overnight at 4uC, the membrane was incubated with mAb A9E8 (diluted 1:2,000 in PBS) or REV-A-positive chicken serum (diluted 1:100 in PBS) at 37uC for 1 h. After being washed three times with PBST, the membrane was probed with a 1:5,000 dilution of HRP-conjugated goat anti-mouse IgG To investigate the conservation of the epitope among REV viruses, sequence alignment of the epitope and the corresponding regions on gp90 proteins of 32 REV-A strains, one REV-T strain, four SNV strains and one CSV strain was performed using the DNASTAR Lasergene program (Windows version; DNASTAR Inc., Madison, WI, USA). keywords: a9e8; cell; epitope; gp90; gst; mab; peptide; phage; protein; rev; virus cache: cord-000813-gagakqw4.txt plain text: cord-000813-gagakqw4.txt item: #76 of 672 id: cord-000833-m6abyuvx author: Sekiguchi, Satoshi title: Immunization with a Recombinant Vaccinia Virus That Encodes Nonstructural Proteins of the Hepatitis C Virus Suppresses Viral Protein Levels in Mouse Liver date: 2012-12-17 words: 5941 flesch: 45 summary: Here, we used poly (I:C)-induced expression of Cre recombinase to generate HCV transgenic mice in order to study the effect of HCV protein and confirmed that these mice developed chronic active hepatitis-including steatosis, lipid deposition, and hepatocellular carcinoma. To determine whether rVV-N25 treatment induced the same effect in other strains of HCV transgenic mice, we analyzed RzCN5-15 (+/2) /MxCre keywords: cn2; hcv; hepatitis; liver; mice; n25; protein; rvv; virus cache: cord-000833-m6abyuvx.txt plain text: cord-000833-m6abyuvx.txt item: #77 of 672 id: cord-000837-rdpsxb4n author: Perez-Pepe, Marcelo title: BUHO: A MATLAB Script for the Study of Stress Granules and Processing Bodies by High-Throughput Image Analysis date: 2012-12-20 words: 7091 flesch: 47 summary: The difference of these values from manual parameters was less than 4% for basal PBs and 10% for induced PBs in Drosophila cells, and less than 7% for basal and 12% for induced PBs in mammalian cells. SGs assemble as a consequence of the global translation silencing provoked by the inactivation of the translation initiation factor 2a (eIF2a) by specific kinases that are activated upon cell stress. keywords: analysis; buho; cells; drosophila; figure; foci; formation; images; number; prototypes; sgs; stress; values cache: cord-000837-rdpsxb4n.txt plain text: cord-000837-rdpsxb4n.txt item: #78 of 672 id: cord-000851-uylgyhs8 author: Wang, Zhenya title: Inhibitory Influence of Enterococcus faecium on the Propagation of Swine Influenza A Virus In Vitro date: 2013-01-07 words: 4529 flesch: 40 summary: Another cytokine stimulated by the probiotic treatment was IL-10, which is a typical Th2 cytokine that is initially repressed in virus infected cells but then expressed at higher levels later in infection to control the initial inflammatory response to infection. The results obtained reveal an almost complete recovery of viability of SwIV infected cells and an inhibition of virus multiplication by up to four log units in the E. faecium treated cells. keywords: 3d4/21; cells; faecium; fig; infection; influenza; probiotic; swiv; virus cache: cord-000851-uylgyhs8.txt plain text: cord-000851-uylgyhs8.txt item: #79 of 672 id: cord-000866-dr2uow4m author: Picard-Jean, Frédéric title: The Immunosuppressive Agent Mizoribine Monophosphate Is an Inhibitor of the Human RNA Capping Enzyme date: 2013-01-17 words: 7085 flesch: 43 summary: In silico docking of MZP on the highly conserved active site of an open conformation homology model of HCE GTase domain provides additional information on the mechanism of MZP binding to this site ( Fig. S4 and Table S1 ). The protein concentration was determined by the Bio-Rad dye binding method and stored at 280uC. The amino acids 1-219 corresponding to HCE RTase domain (HCE-T 1-219 ) and 229-597 corresponding to HCE GTase domain (HCE-G 229-597 ) were also expressed separately using the same procedure. keywords: activity; capping; domain; enzyme; gtase; hce; inhibition; mizoribine; mrna; mzp; protein; reaction; rna cache: cord-000866-dr2uow4m.txt plain text: cord-000866-dr2uow4m.txt item: #80 of 672 id: cord-000868-vnwpzsu8 author: Eissmann, Kristin title: HIV-1 Fusion Is Blocked through Binding of GB Virus C E2D Peptides to the HIV-1 gp41 Disulfide Loop date: 2013-01-22 words: 9147 flesch: 46 summary: We demonstrate that E2 peptides act late after CD4 and coreceptor engagement via binding the gp41 disulfide loop region, a new promising target for HIV-1 entry inhibition. PHA/IL-2-stimulated PBMC or TZM-bl cells were incubated with E2 peptides (25 mM), phorbol 12-myristate 13-acetate (PMA; 40 ng/ml), SDF-1a (1 mg/ml) or RANTES (50 nM) for 6 hr. keywords: binding; c e2; cd4; cells; disulfide; entry; fusion; gbv; gp120; gp41; hiv; loop; peptides; protein; region; virus cache: cord-000868-vnwpzsu8.txt plain text: cord-000868-vnwpzsu8.txt item: #81 of 672 id: cord-000877-usz7pnvu author: Abdel-Moneim, Ahmed S. title: Detection of Bocavirus in Children Suffering from Acute Respiratory Tract Infections in Saudi Arabia date: 2013-01-30 words: 1832 flesch: 48 summary: Swabs samples from 80 children with respiratory tract infections were examined for the presence of HBoV. Real-time polymerase chain reaction was used as a sensitive method to detect the HBoV. Direct gene sequencing was used to determine the genotype of the detected virus isolates. It was then detected in children with respiratory tract infections in addition to gastroenteritis worldwide [9] [10] [11] [12] . keywords: bocavirus; children; hbov; human; infections; tract cache: cord-000877-usz7pnvu.txt plain text: cord-000877-usz7pnvu.txt item: #82 of 672 id: cord-000895-z5rdf0mi author: Belalov, Ilya S. title: Causes and Implications of Codon Usage Bias in RNA Viruses date: 2013-02-25 words: 5459 flesch: 39 summary: A series of in silico shuffling algorithms were developed to account for these features and analyze the relative impact of mutational pressure components on codon usage bias in RNA viruses. The algorithms presented here provide a substantial improvement in dissecting origins of codon usage bias in RNA viruses. keywords: bias; codon; content; dinucleotide; enc; position; rna; usage; viruses cache: cord-000895-z5rdf0mi.txt plain text: cord-000895-z5rdf0mi.txt item: #83 of 672 id: cord-000905-1rhlu59c author: Cyktor, Joshua C. title: Clonal Expansions of CD8(+) T Cells with IL-10 Secreting Capacity Occur during Chronic Mycobacterium tuberculosis Infection date: 2013-03-05 words: 5796 flesch: 43 summary: T cells Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses PD-1 and its ligands in tolerance and immunity Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis Protection against Mycobacterium tuberculosis infection by CD8+ T cells requires the production of gamma interferon Contribution of CD8+ T cells to control of Mycobacterium tuberculosis infection V beta 17 T-cell deletion by endogenous mammary tumor virus in wild-type-derived mouse strain Murine T-cell receptor mutants with deletions of beta-chain variable region genes Highly focused T cell responses in latent human pulmonary Mycobacterium tuberculosis infection Clonal B cells in patients with hepatitis C virus-associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subset Predominant clonal accumulation of CD8+ T cells with moderate avidity in the central nervous systems of Theiler's virus-infected C57BL/6 mice Inclusion body myositis with human immunodeficiency virus infection: four cases with clonal expansion of viral-specific T cells CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion Clonal evolution of blasts in an elderly patient with CD56(+) relapsed acute promyelocytic leukemia Clonal immune responses of Mycobacterium-specific gammadelta T cells in tuberculous and non-tuberculous tissues during M. tuberculosis infection Accelerated induction of mycobacterial antigen-specific CD8+ T cells in the Mycobacterium tuberculosis-infected lung by subcutaneous vaccination with Mycobacterium bovis bacille Calmette-Guerin CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination New TB vaccines: is there a requirement for CD8 T cells? Activation of CD8 T cells by mycobacterial vaccination protects against pulmonary tuberculosis in the absence of CD4 T cells CD8 cytotoxic T cells and the development of new tuberculosis vaccines Studies have also reported that CD8 + T cells are most important during latent Mtb infection in mice, and that CD8 + T cell depletion early after infection had little effect on disease outcome [18] . keywords: cba; cd8; cells; il-10; infection; mice; mtb; tuberculosis cache: cord-000905-1rhlu59c.txt plain text: cord-000905-1rhlu59c.txt item: #84 of 672 id: cord-000912-6l6c7jpq author: Vitelli, Alessandra title: Vaccination to Conserved Influenza Antigens in Mice Using a Novel Simian Adenovirus Vector, PanAd3, Derived from the Bonobo Pan paniscus date: 2013-03-11 words: 4665 flesch: 44 summary: A single intranasal administration of PanAd3-NPM1 vaccine induced strong antibody and T cell responses, and protected against high dose lethal influenza virus challenge. Peptide scanning of T cell responses of healthy human individuals has shown that matrix 1 (M1) and nucleoprotein (NP) are among the prominent targets of CD8 + and CD4 + T cell cross-recognition keywords: adenovirus; cell; human; immunity; influenza; mice; npm1; panad3; responses; vaccine; vectors cache: cord-000912-6l6c7jpq.txt plain text: cord-000912-6l6c7jpq.txt item: #85 of 672 id: cord-000937-8vk89i4h author: Law, John title: Identification of Hepatotropic Viruses from Plasma Using Deep Sequencing: A Next Generation Diagnostic Tool date: 2013-04-17 words: 6656 flesch: 45 summary: To a lesser extent (about one read per million), we also detected sequences resembling RNA viruses in our DNA libraries (Supplemental Tables S15-S28 ). This may represent alignment inaccuracies or stretches of unknown DNA viruses that resemble RNA viruses. keywords: dna; ends; figure; hepatitis; libraries; library; patients; plasma; read; rna; samples; sequences; target; viral; viruses cache: cord-000937-8vk89i4h.txt plain text: cord-000937-8vk89i4h.txt item: #86 of 672 id: cord-000947-psguw47w author: Feng, Jianyu title: A Study of the Mechanism of the Chaperone-like Function of an scFv of Human Creatine Kinase by Computer Simulation date: 2013-04-24 words: 4721 flesch: 51 summary: programs for checking the quality of protein structures solved by NMR A method to identify protein sequences that fold into a known three-dimensional structure ElliPro: a new structure-based tool for the prediction of antibody epitopes ZDOCK: First set of peptides covered HCK sequence was spotted in squares A1 to M9. keywords: antibodies; binding; chaperone; epitopes; hck; membrane; peptide; protein; scfv cache: cord-000947-psguw47w.txt plain text: cord-000947-psguw47w.txt item: #87 of 672 id: cord-000959-nk2thkme author: Downer, Eric J. title: Identifying Early Inflammatory Changes in Monocyte-Derived Macrophages from a Population with IQ-Discrepant Episodic Memory date: 2013-05-06 words: 5417 flesch: 43 summary: [30] and T cell memory TLR4 expression on CD11b + PBMCs was similar in HP and LP groups and this is also shown in the representative dot plots of TLR4 + cells (O) which indicate the percentage positive cells. keywords: cd11b; cells; expression; group; lps; mdms; memory; monocytes; pbmcs; tlr2; tlr4 cache: cord-000959-nk2thkme.txt plain text: cord-000959-nk2thkme.txt item: #88 of 672 id: cord-000979-cav9n18w author: Hoppe, Sebastian title: Rapid Identification of Novel Immunodominant Proteins and Characterization of a Specific Linear Epitope of Campylobacter jejuni date: 2013-05-29 words: 10065 flesch: 45 summary: NCBI gene expression and hybridization array data repository Primer3 on the WWW for general users and for biologist programmers Geneious v5 Basic local alignment search tool Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins Predicting transmembrane protein topology with a hidden Markov model: Application to complete genomes A hidden Markov model for predicting transmembrane helices in protein sequences A semi-empirical method for prediction of antigenic determinants on protein antigens New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and x-ray derived accessible sites The SWISS-MODEL Workspace: A web-based environment for protein structure homology modeling The SWISS-MODEL Repository and associated resources SWISS-MODEL: an automated protein homology-modeling server SWISS-MODEL and the Swiss-PdbViewer: A case-control study in FoodNet sites Typing of Campylobacter jejuni and Campylobacter coli isolated from live broilers and retail broiler meat by flaA-RFLP, MLST, PFGE and REP-PCR Rapid pulsed-field gel electrophoresis protocol for subtyping of Campylobacter jejuni Evaluation of three commercial latex agglutination tests for identification of Campylobacter spp Molecular Cloning: A Laboratory Manual, Third Edition Severe acute respiratory syndrome diagnostics using a coronavirus protein microarray Immunogenic cross-reaction among outer membrane proteins of Gram-negative bacteria Microarray-based method for screening of immunogenic proteins from bacteria Proteinprotein interactions: analysis of a false positive GST pulldown result HaloTag: a novel protein labeling technology for cell imaging and protein analysis Validation of two ribosomal RNA removal methods for microbial metatranscriptomics Polyadenylic acid sequences in E. coli messenger RNA Identification of the gene for an Escherichia coli poly(A) polymerase A simple method to enrich mRNA from prokaryotic RNA Magnetic capturehybridization method for purification and probing of mRNA for neutral protease of Bacillus cereus Direct detection of recombinant gene expression by two genetically engineered yeasts in soil on the transcriptional and translational level Normalization of full-length-enriched cDNA Duplex-specific nuclease efficiently removes rRNA for prokaryotic RNA-seq Ligation-independent cloning of PCR products (LIC-PCR) High efficiency transformation of E. coli by high voltage electroporation The Campylobacter jejuni/coli CjaA (cj0982c) gene encodes an N-glycosylated lipoprotein localized in the inner membrane Genetic diversity of the Campylobacter genes coding immunodominant proteins Immunogenicity and immunoprotection of recombinant PEB1 in Campylobacter-jejuni-infected mice The National Center for Biotechnology Information's Protein Clusters Database Characterization of Genetically Matched Isolates of Campylobacter jejuni Reveals that Mutations in Genes Involved in Flagellar Biosynthesis Alter the Organism's Virulence Potential Nutrient Acquisition and Metabolism by Campylobacter jejuni Identification of Campylobacter jejuni Genes Contributing to Acid Adaptation by Transcriptional Profiling and Genome-Wide Mutagenesis Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems The Protein Data Bank: A Computer-based Archival File for Macromolecular Structures The 2.0 Crystal Structure of ABC Transporter from Thermatoga maritima Toward the estimation of the absolute quality of individual protein structure models Construction and Evaluation of Normalized cDNA keywords: antibodies; antibody; antigenic; binding; campylobacter; cdna; epitope; immunodominant; incubation; jejuni; linear; min; pcr; proteins; reaction; rna; screening; sequence; specific cache: cord-000979-cav9n18w.txt plain text: cord-000979-cav9n18w.txt item: #89 of 672 id: cord-000981-6vloa2w3 author: Bálint, Zoltán title: Double-Stranded RNA Attenuates the Barrier Function of Human Pulmonary Artery Endothelial Cells date: 2013-06-03 words: 6110 flesch: 45 summary: Despite the obvious clinical implications associated with the presence of circulating RNA, its pathological effects on endothelial cells and the governing molecular mechanisms are still not fully elucidated. Endothelial cells express toll-like receptor 3 (TLR3) keywords: cells; control; dsrna; effect; endothelial; figure; hpaecs; min; permeability; serca; treatment cache: cord-000981-6vloa2w3.txt plain text: cord-000981-6vloa2w3.txt item: #90 of 672 id: cord-000984-64p3wpav author: Huang, Shang-Hui title: Self-Oligomerization Is Essential for Enhanced Immunological Activities of Soluble Recombinant Calreticulin date: 2013-06-10 words: 5265 flesch: 46 summary: Samples of the eluted fractions were assayed by SDS-PAGE (Fig. 1A) , which showed that the eluent between 360-380 mM NaCl contained protein bands of the expected molecular weight for nCRT (55 kDa), which showed approximately 90% homogeneity judging by density of the major band in Coomassie blue (CBB)-stained gel (Fig. 1C ). In our previous study, rCRT/39-272 could effectively activate mouse macrophages in vitro keywords: binding; calreticulin; crt; domain; fig; kda; lps; macrophages; ncrt; protein; rcrt/18; residues cache: cord-000984-64p3wpav.txt plain text: cord-000984-64p3wpav.txt item: #91 of 672 id: cord-001007-645zegcv author: Kim, Hak title: Identification of Recombinant Human Rhinovirus A and C in Circulating Strains from Upper and Lower Respiratory Infections date: 2013-06-27 words: 4065 flesch: 39 summary: For HRV-A, there were five cases (4.8%) of intraspecies recombination events and three cases (2.8%) of interspecies recombination events. For HRV-C, there were four cases (3.8%) of intraspecies recombination events and seven cases (6.7%) of interspecies recombination events. keywords: cases; events; hrv; hrvs; recombination; sequences; strains; vp2; vp4 cache: cord-001007-645zegcv.txt plain text: cord-001007-645zegcv.txt item: #92 of 672 id: cord-001011-vjxmrmfc author: Lei, Daoxiong title: Hepatic Deficiency of COP9 Signalosome Subunit 8 Induces Ubiquitin-Proteasome System Impairment and Bim-Mediated Apoptosis in Murine Livers date: 2013-07-01 words: 6063 flesch: 39 summary: We also presented the first evidence that the upregulation of pro-apoptotic protein Bim and its interaction with Bcl2 may have mediated the Bax-dependent activation of the intrinsic pathway of hepatocyte apoptosis in Csn8 deficient livers. The present study demonstrates that Csn8 deficiency compromises protein deneddylation, differentially downregulates substrate receptor proteins of CRLs, and selectively accumulates CRL substrates such as pro-apoptotic protein Bim, and reduces 19S proteasome subunit Rpt5, leading to severe UPS functional impairment and massive apoptosis in hepatocytes of intact mice. keywords: apoptosis; bax; bcl2; bim; cell; csn8ko; figure; livers; mice; proteasome; protein; ups cache: cord-001011-vjxmrmfc.txt plain text: cord-001011-vjxmrmfc.txt item: #93 of 672 id: cord-001014-8yrpcl94 author: Kitagawa, Hiroshi title: Intranasally Administered Antigen 85B Gene Vaccine in Non-Replicating Human Parainfluenza Type 2 Virus Vector Ameliorates Mouse Atopic Dermatitis date: 2013-07-03 words: 4475 flesch: 50 summary: hPIV2 is a virus infectious to the respiratory tract mucosa, and therefore more effective capture of rhPIV2/Ag85B by respiratory epithelium compared with that of skin resident cells is reasonable. AD, especially in its acute phase, is a disease that Th2 cells are dominantly involved in the pathogenesis. keywords: ag85b; cells; ear; egfp; mice; rhpiv2; skin; treated; type; virus cache: cord-001014-8yrpcl94.txt plain text: cord-001014-8yrpcl94.txt item: #94 of 672 id: cord-001021-nag4at49 author: Shaheen, Hussam H. title: A Dual-Mode Surface Display System for the Maturation and Production of Monoclonal Antibodies in Glyco-Engineered Pichia pastoris date: 2013-07-10 words: 4749 flesch: 41 summary: As shown in Figure 3A , yeasts displaying anti-Her2 on cell surface were able to bind to the anti-Fc reagent only, while cells displaying anti-PCSK9 reacted with both biotinylated PCSK9 antigen and anti-human Fc antibody ( Figure 3B ). We assayed antibody display and expression in each strain following cultivation in 1L bioreactors by two independent methods. keywords: antibody; cell; chain; display; human; igg; length; pastoris; pcsk9; pichia; surface cache: cord-001021-nag4at49.txt plain text: cord-001021-nag4at49.txt item: #95 of 672 id: cord-001039-qocuprwb author: Hayasaka, Daisuke title: TNF-α Acts as an Immunoregulator in the Mouse Brain by Reducing the Incidence of Severe Disease Following Japanese Encephalitis Virus Infection date: 2013-08-05 words: 8611 flesch: 46 summary: Stocks of JEV JaOArS982 and JaTH160 viruses were obtained from cell culture medium of baby hamster kidney (BHK) cells infected with viruses previously prepared in suckling mouse brains [49] . Fields virology Past, present, and future of Japanese encephalitis Natural Japanese encephalitis virus infection among humans in west and east Japan shows the need to continue a vaccination program Overview: Japanese encephalitis New initiatives for the control of Japanese encephalitis by vaccination: minutes of a WHO/CVI meeting Immunobiology of Japanese Encephalitis Virus Proinflammatory cytokines and chemokines in humans with Japanese encephalitis Correlation of tumor necrosis factor levels in the serum and cerebrospinal fluid with clinical outcome in Japanese encephalitis patients Flavivirus encephalitis: pathological aspects of mouse and other animal models A preliminary neuropathological study of Japanese encephalitis in humans and a mouse model Comparative study of mouse brains infected with Japanese encephalitis virus by intracerebral or intraperitoneal inoculation West Nile virus encephalitis: sequential histopathological and immunological events in a murine model of infection Pathogenesis of neurotropic arbovirus infections Flaviviruses. keywords: days; disease; encephalitis; figure; il-10; infected; infection; jaoars982; levels; mice; tnf; virus cache: cord-001039-qocuprwb.txt plain text: cord-001039-qocuprwb.txt item: #96 of 672 id: cord-001045-jm60nxc2 author: DeLisle, Sylvain title: Using the Electronic Medical Record to Identify Community-Acquired Pneumonia: Toward a Replicable Automated Strategy date: 2013-08-13 words: 4334 flesch: 39 summary: Specialized software development is not required for automated text analyses to help identify pneumonia patients. Prior attempts to automatically identify pneumonia patients through medical records have concentrated on diagnostic codes assigned after hospital discharge. keywords: ari; cda; chest; data; imaging; patients; pneumonia; reports; text cache: cord-001045-jm60nxc2.txt plain text: cord-001045-jm60nxc2.txt item: #97 of 672 id: cord-001065-j4hvyyoi author: Boncristiani, Humberto F. title: In Vitro Infection of Pupae with Israeli Acute Paralysis Virus Suggests Disturbance of Transcriptional Homeostasis in Honey Bees (Apis mellifera) date: 2013-09-05 words: 6377 flesch: 40 summary: The high concentration of IAPV over other honey bee viruses in these purifications allowed us to strongly dilute the inoculum, decreasing the chances of cross inoculation with another virus. Attempts to isolate pure IAPV directly from naturally infected adult bees were unsuccessful due to co-infection of the bees with other honey bee viruses. keywords: bee; bees; colonies; colony; expression; gene; honey; iapv; infection; pbs; pupae; replication; time; treatment; virus; viruses cache: cord-001065-j4hvyyoi.txt plain text: cord-001065-j4hvyyoi.txt item: #98 of 672 id: cord-001071-bjx5td52 author: Vanhems, Philippe title: Estimating Potential Infection Transmission Routes in Hospital Wards Using Wearable Proximity Sensors date: 2013-09-11 words: 5047 flesch: 41 summary: The collected data can provide information on important aspects that impact the spreading patterns of infectious diseases, such as the strong heterogeneity of contact numbers and durations across individuals, the variability in the number of contacts during a day, and the fraction of repeated contacts across days. Contact patterns were qualitatively similar from one day to the next. keywords: contacts; data; duration; individuals; number; patterns; staff; time; transmission cache: cord-001071-bjx5td52.txt plain text: cord-001071-bjx5td52.txt item: #99 of 672 id: cord-001078-5m29nugu author: Chen, Xiaorong title: Clinical Features and Factors Associated with Outcomes of Patients Infected with a Novel Influenza A (H7N9) Virus: A Preliminary Study date: 2013-09-17 words: 3948 flesch: 43 summary: C-reactive protein level might be used as an early marker for clinical prognosis in H7N9 patients based on results from our logistic regression analyses, which was in agreement with previous studies showing that C-reactive protein level might serve as a marker for severity of illness in influenza infections [18, 19] . Elderly people may have increased risk for H7N9 virus infection. keywords: avian; group; h7n9; infection; influenza; patients; therapy; treatment; virus cache: cord-001078-5m29nugu.txt plain text: cord-001078-5m29nugu.txt item: #100 of 672 id: cord-001083-vy1nxax2 author: Malagnac, Fabienne title: Rab-GDI Complex Dissociation Factor Expressed through Translational Frameshifting in Filamentous Ascomycetes date: 2013-09-19 words: 6838 flesch: 52 summary: The corrected version of the PaYIP3 CDS was PCR amplified using the PhusionH High-Fidelity DNA Polymerase, P. anserina PaYIP3 C The corrected in-frame form (PaYIP3 C -GFP) is more difficult to observe in the hyphae, as expected if it is present in lower amounts. keywords: -gfp; anserina; fig; frameshifting; gene; payip3; payip3 c; protein; pseudoknot; sequence; slippery; type; wild cache: cord-001083-vy1nxax2.txt plain text: cord-001083-vy1nxax2.txt item: #101 of 672 id: cord-001088-dugsh7mp author: Kim, So-Hee title: Mucosal Vaccination with Recombinant Adenovirus Encoding Nucleoprotein Provides Potent Protection against Influenza Virus Infection date: 2013-09-25 words: 5502 flesch: 27 summary: A virus infection induces cross-protective immunity against a lethal infection with a heterosubtypic virus strain in mice Comparison of vaccines for induction of heterosubtypic immunity to influenza A virus: cold-adapted vaccine versus DNA prime-adenovirus boost strategies Cold-adapted influenza and recombinant adenovirus vaccines induce cross-protective immunity against pH1N1 challenge in mice A universal influenza A vaccine based on adenovirus expressing matrix-2 ectodomain and nucleoprotein protects mice from lethal challenge Sublingual administration of bacteria-expressed influenza virus hemagglutinin 1 (HA1) induces protection against infection with 2009 pandemic H1N1 influenza virus Evaluation of the sublingual route for administration of influenza H5N1 virosomes in combination with the bacterial second messenger c-di-GMP Intranasal vaccination with H5, H7 and H9 hemagglutinins co-localized in a virus-like particle protects ferrets from multiple avian influenza viruses A simplified system for generating recombinant adenoviruses Dual role of respiratory syncytial virus glycoprotein fragment as a mucosal immunogen and chemotactic adjuvant Sublingual vaccination with influenza virus protects mice against lethal viral infection Immunogenicity and protective efficacy of a dual subunit vaccine against respiratory syncytial virus and influenza virus Adenovirus-vectored drug-vaccine duo as a rapid-response tool for conferring seamless protection against influenza Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein Induction of virusspecific cytotoxic T lymphocytes as a basis for the development of broadly protective influenza vaccines Evidence for a correlation between antibody-dependent cellular cytotoxicity-mediating anti-HIV-1 antibodies and prognostic predictors of HIV infection Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes Expression of influenza A virus internal antigens on the surface of infected P815 cells Adenoviruses as vaccine vectors Safety and immunogenicity of adenovirus-vectored nasal and epicutaneous influenza vaccines in humans Single mucosal immunization of recombinant adenovirus-based vaccine expressing F1 protein fragment induces protective mucosal immunity against respiratory syncytial virus infection Nasal delivery of an adenovirus-based vaccine bypasses pre-existing immunity to the vaccine carrier and improves the immune response in mice Pathogen recognition and inflammatory signaling in innate immune defenses Tissue distribution of lymphocytes and plasma cells and the role of the gut Vaccines: correlates of vaccine-induced immunity Human immune responses to influenza virus vaccines administered by systemic or mucosal routes New strategies for using mucosal vaccination to achieve more effective immunization Single mucosal, but not parenteral, immunization with recombinant adenoviral-based vaccine provides potent protection from pulmonary tuberculosis Enhanced mucosal immunoglobulin A response of intranasal adenoviral vector human immunodeficiency virus vaccine and localization in the central nervous system Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain Mucosal IgA responses in influenza virus infections; thoughts for vaccine design Crossprotection in mice infected with influenza A virus by the respiratory route is correlated with local IgA antibody rather than serum antibody or cytotoxic T cell reactivity Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity Differential antigen presentation regulates the changing patterns of CD8+ T cell immunodominance in primary and secondary influenza virus infections Ecological and immunological determinants of influenza evolution A novel role for non-neutralizing antibodies against nucleoprotein in facilitating resistance to influenza virus Contributions of antinucleoprotein IgG to heterosubtypic immunity against influenza virus Universal vaccine based on ectodomain of matrix protein 2 of influenza A: Fc receptors and alveolar macrophages mediate protection Accordingly, we engineered a recombinant adenovirus expressing full-length NP derived from PR8 influenza virus as a potential vaccine candidate in order to investigate whether priming for NP-specific immune responses could offer crossprotection against different strains and subtypes of influenza virus. keywords: challenge; i.n; immunization; influenza; mice; mucosal; protection; rad; vaccine; virus cache: cord-001088-dugsh7mp.txt plain text: cord-001088-dugsh7mp.txt item: #102 of 672 id: cord-001090-qg2r691d author: Twin, Jimmy title: The Potential of Metatranscriptomics for Identifying Screening Targets for Bacterial Vaginosis date: 2013-09-27 words: 3948 flesch: 37 summary: Overall, this library consisted of 72826 (93%) bacterial reads, 3865 (4.9%) human reads and 34 (0.04%) either plastid, fungal or viral reads (Table 1) . The metagenomics RAST server -a public resource for the automatic phylogenetic and functional analysis of metagenomes Study of inter-and intra-individual variations in the salivary microbiota Interactive metagenomic visualization in a Web browser Changes in vaginal bacterial concentrations with intravaginal metronidazole therapy for bacterial vaginosis as assessed by quantitative PCR Detection of bacterial vaginosis-related organisms by real-time PCR for Lactobacilli, Gardnerella vaginalis and Mycoplasma hominis Comparative assessment of human and farm animal faecal microbiota using real-time quantitative PCR Diversity of cervicovaginal microbiota associated with female lower genital tract infections Inverse association of H 2 O 2 -producing lactobacilli and vaginal Escherichia coli colonization in women with recurrent urinary tract infections Broadrange bacterial detection and the analysis of unexplained death and critical illness Stata Statistical Software: Release 12 Bacterial communities in women with bacterial vaginosis: high resolution phylogenetic analyses reveal relationships of microbiota to clinical criteria Evidence for a commensal, symbiotic relationship between Gardnerella vaginalis and Prevotella bivia involving ammonia: potential significance for bacterial vaginosis Prevotella amnii sp. keywords: 16s; amnii; cdna; dna; library; prevotella; reads; rrna; study cache: cord-001090-qg2r691d.txt plain text: cord-001090-qg2r691d.txt item: #103 of 672 id: cord-001092-pkps5j8w author: Coleman, Ryan G. title: Ligand Pose and Orientational Sampling in Molecular Docking date: 2013-10-01 words: 9892 flesch: 46 summary: The former relied on an implementation of DOCK's traditional hotspot-based graph matching [81, 82] which focused the search for complementary ligand orientations to the protein likely to lead to favorable fits, while the latter eliminated the need to build ligand conformations on the fly, especially useful when docking the same ligand to multiple proteins as the time is saved for additional screens beyond the first. Similarly we were concerned about the sampling of ligand conformations in the flexibase. keywords: atoms; conformations; decoys; discovery; docking; dud; energy; enrichment; inhibitors; ligand; novel; orientations; poses; protein; receptor; sampling; scoring; screening; structure; targets cache: cord-001092-pkps5j8w.txt plain text: cord-001092-pkps5j8w.txt item: #104 of 672 id: cord-001099-jirkkkvy author: Yousuf, Mohammad A. title: Caveolin-1 Associated Adenovirus Entry into Human Corneal Cells date: 2013-10-11 words: 7144 flesch: 41 summary: The influence of innate and pre-existing immunity on adenovirus therapy A new link between virus cell entry and inflammation: adenovirus interaction with integrins induces specific proinflammatory responses Viral capsid is a pathogen-associated molecular pattern in adenovirus keratitis Preferential activation of Toll-like receptor nine by CD46-utilizing adenoviruses CD46-utilizing adenoviruses inhibit C/EBPbeta-dependent expression of proinflammatory cytokines Virus Entry by Endocytosis Lipid rafts mediate chemotropic guidance of nerve growth cones Low cholesterol triggers membrane microdomain-dependent CD44 shedding and suppresses tumor cell migration Caveolin, a protein component of caveolae membrane coats Identification, sequence, and expression of caveolin-2 defines a caveolin gene family Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice Endocytosis of simian virus 40 into the endoplasmic reticulum Role of endosomes in simian virus 40 entry and infection Association of the Caveola vesicular system with cellular entry by filoviruses A novel cell entry pathway for a DAF-using human enterovirus is dependent on lipid rafts Internalization of echovirus 1 in caveolae Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection Rift Valley fever virus strain MP-12 enters mammalian host cells via Caveola-mediated endocytosis Entry of tiger frog virus (an Iridovirus) into HepG2 cells via a pH-dependent, atypical, Caveola-mediated endocytosis pathway Caveola-dependent endocytic entry of amphotropic murine leukemia virus Human coronavirus 229E binds to CD13 in rafts and enters the cell through caveolae Heparan sulfate-binding footand-mouth disease virus enters cells via Caveola-mediated endocytosis Viruses and endosome membrane dynamics Virus entry by endocytosis Focal adhesion kinase plays a pivotal role in herpes simplex virus entry Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinase ERK1/2 and MEK1/2 induced by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) early during infection of target cells are essential for expression of viral genes and for establishment of infection HijAkt: The PI3K/Akt pathway in virus replication and pathogenesis Role of alpha(v) integrins in adenovirus cell entry and gene delivery Corneal cell survival in adenovirus type 19 infection requires phosphoinositide 3-kinase/Akt activation Respiratory syncytial virus inhibits apoptosis and induces NFkappa B activity through a phosphatidylinositol 3-kinase-dependent pathway Genome-wide analysis of human kinases in clathrin-and caveolae/raftmediated endocytosis Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5 Adenovirus serotype 35 vector-mediated transduction into human CD46-transgenic mice The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3 Viruses can often circumvent artificial barriers to cell entry by use of alternate entry pathways [50, 60, 61] . keywords: adenovirus; caveolae; caveolin-1; cells; corneal; d37; endocytosis; entry; fractions; hadv; human; infection; lipid; min; src; virus cache: cord-001099-jirkkkvy.txt plain text: cord-001099-jirkkkvy.txt item: #105 of 672 id: cord-001117-llb4f74a author: Ji, Wen-Jie title: Spironolactone Attenuates Bleomycin-Induced Pulmonary Injury Partially via Modulating Mononuclear Phagocyte Phenotype Switching in Circulating and Alveolar Compartments date: 2013-11-19 words: 4983 flesch: 28 summary: In addition, recent studies demonstrated that lung alveolar macrophages are established prior to birth and maintains themselves subsequently during adulthood independent of replenishment from circulating monocyte input in steady state Second, we did not observed significant changes in lung interstitial macrophages by spironolactone. keywords: alveolar; analysis; bleomycin; cells; fibrosis; inflammation; injury; lung; macrophages; monocytes; mouse; spironolactone; tissue cache: cord-001117-llb4f74a.txt plain text: cord-001117-llb4f74a.txt item: #106 of 672 id: cord-001120-fxd533b4 author: Everitt, Aaron R. title: Defining the Range of Pathogens Susceptible to Ifitm3 Restriction Using a Knockout Mouse Model date: 2013-11-21 words: 4881 flesch: 40 summary: In wild type mice, the expression pattern of Ifitm3 was noteworthy. The ~50% survival of wild type mice falls within acceptable boundaries owing to inherent inefficiencies in the delivery of parasites into the mice [28] . keywords: cell; days; figure; ifitm3; infection; influenza; mice; mouse; restriction; role; rsv; type; virus cache: cord-001120-fxd533b4.txt plain text: cord-001120-fxd533b4.txt item: #107 of 672 id: cord-001123-n2e4s7bu author: Lin, Yue-Zhi title: The Soluble Form of the EIAV Receptor Encoded by an Alternative Splicing Variant Inhibits EIAV Infection of Target Cells date: 2013-11-22 words: 5900 flesch: 45 summary: Therefore, the present study had three objectives: 1) to identify alternative splicing variants for ELR1, 2) to determine whether any of these variants encode soluble ELR1 and 3) to characterize the roles of any soluble forms of the receptor in EIAV infection. Horses and related experimental protocols used in this study were approved by the Institutional Animal Care and Use Committee (IACUC) of the Harbin Veterinary Research Institute (HVRI), Chinese Academy of Agricultural Sciences. The expression of soluble ELR1 (sELR1) was examined by Western blot, flow cytometry and confocal microscopy. keywords: cells; eiav; elr1; equine; expression; gfp; infection; mrna; protein; receptor; soluble; virus cache: cord-001123-n2e4s7bu.txt plain text: cord-001123-n2e4s7bu.txt item: #108 of 672 id: cord-001126-uqr00nzd author: Zhang, Zhicheng title: Synonymous Codon Usage in TTSuV2: Analysis and Comparison with TTSuV1 date: 2013-11-26 words: 4905 flesch: 40 summary: Studies have indicated that synonymous codon usage is non-random and species-specific [1] . We previously investigated synonymous codon usage in TTSuV1 [29] and began to suspect that this method might be important for elucidating the molecular mechanism and evolutionary process of TTSuV. In this study, synonymous codon usage bias was analyzed in the coding sequences (CDS) from the 41 available TTSuV2 genomes, and the codon usage patterns of TTSuV2 and TTSuV1 were compared. keywords: analysis; bias; codon; genomes; ttsuv2; usage; virus cache: cord-001126-uqr00nzd.txt plain text: cord-001126-uqr00nzd.txt item: #109 of 672 id: cord-001129-gi2kswai author: Lemos de Matos, Ana title: Positive Evolutionary Selection On the RIG-I-Like Receptor Genes in Mammals date: 2013-11-27 words: 6982 flesch: 42 summary: For RIG-I, the greatest number of codons identified as candidates under selective pressures were located in known protein functional domains, which might reveal the pressure imposed by the great number of viruses recognized by this RLR The coding region of the three RLR genes, RIG-I, MDA5 and LGP2, were collected for different mammalian species from NCBI (http://www.ncbi.nlm.nih.gov) and Ensembl (http:// www.ensembl.org/index.html) databases (Table S1 ). keywords: alignment; figure; gene; lgp2; mammalian; mda5; nucleotide; rig; rna; selection; sequences; site; species cache: cord-001129-gi2kswai.txt plain text: cord-001129-gi2kswai.txt item: #110 of 672 id: cord-001142-puj74k7y author: Crescenzo-Chaigne, Bernadette title: The Panhandle Formed by Influenza A and C Virus NS Non-Coding Regions Determines NS Segment Expression date: 2013-11-21 words: 3360 flesch: 48 summary: Our results thus provide useful information to improve our understanding of influenza A virus biology. Evolution and ecology of influenza A viruses Orthomyxoviridae: The viruses and their replication Mutations in the nonconserved noncoding sequences of the influenza A virus segments affect viral vRNA formation Non coding extremities of the seven influenza virus type C vRNA segments: effect on transcription and replication by the type C and type A polymerase complexes Molecular studies of influenza B virus in the reverse genetics era The 3' and 5'-terminal sequences of influenza A, B and C virus RNA segments are highly conserved and show partial inverted complementarity 5' and 3' terminal nucleotide sequences of the RNA genome segments of influenza virus Segment-specific and common nucleotide sequences in the noncoding regions of influenza B virus genome RNAs Orthomyxovirus replication, transcription, and polyadenylation Differential effect of nucleotide substitutions in the 3' arm of the influenza A virus vRNA promoter on transcription/replication by avian and human polymerase complexes is related to the nature of PB2 amino acid 627 The influenza virus panhandle is involved in the initiation of transcription Characterization of the RNA-fork model of virion RNA in the initiation of transcription in influenza A virus Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle Structure of influenza virus panhandle RNA studied by NMR spectroscopy and molecular modeling Nucleotides at the extremities of the viral RNA of influenza C virus are involved in typespecific interactions with the polymerase complex Mutational analysis of the influenza virus cRNA promoter and identification of nucleotides critical for replication Promoter elements in the influenza vRNA terminal structure A hairpin loop at the 5' end of influenza A virus virion RNA is required for synthesis of poly(A)+ mRNA in vitro Rescue of influenza A virus from recombinant Generation of influenza A viruses entirely from cloned cDNAs Rescue of influenza C virus from recombinant A molecular mechanism of complement resistance of human melanoma cells Specific residues of the influenza A virus hemagglutinin viral RNA are important for efficient packaging into budding virions Development of a quantitative assay for SARS coronavirus and correlation of GAPDH mRNA with SARS coronavirus in clinical specimens Naked RNA immunization with replicons derived from poliovirus and Semliki Forest virus genomes for the generation of a cytotoxic T cell response against the influenza A virus nucleoprotein Incorporation of influenza A virus genome segments does not absolutely require wild-type sequences For the 3' and 5' ends, respectively, the conserved parts are 12 and 13 nt for type A, 12 and 11nt for type B and 11 and 12 nt for type C influenza viruses [6] [7] [8] . keywords: cells; influenza; panhandle; rna; segment; type; viruses cache: cord-001142-puj74k7y.txt plain text: cord-001142-puj74k7y.txt item: #111 of 672 id: cord-001145-hc9ssruz author: Akazawa, Yuko title: Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis date: 2013-12-13 words: 6302 flesch: 46 summary: Collectively, this study reveals a possible association between VacA-induced apoptosis in gastric epithelial cells, and activation of ER stress in H. pylori-positive gastric mucosa. Infection with Helicobactor pylori (H. pylori) may result in chronic gastritis, gastric ulcer, and gastric cancer The principal findings of this study indicate the following: (i) VacA induces ER stress in gastric epithelial cells, especially in the presence of NH 4 Cl, (ii) VacA-induced apoptosis is at least in part, dependent on activation of CHOP-mediated intracellular signaling, (iii) ER stress is responsible for induction of pro-apoptotic BH3-only protein Bim as well as Bax activation, and (iv) ER stress markers and BH3-only proteins are up-regulated in H. pylori infected-human gastric mucosa. keywords: apoptosis; cells; chop; gastric; perk; pylori; sirna; stress; vaca cache: cord-001145-hc9ssruz.txt plain text: cord-001145-hc9ssruz.txt item: #112 of 672 id: cord-001162-z8cbbit3 author: Yun, Heather C. title: Pandemic Influenza Virus 2009 H1N1 and Adenovirus in a High Risk Population of Young Adults: Epidemiology, Comparison of Clinical Presentations, and Coinfection date: 2014-01-08 words: 3368 flesch: 34 summary: key: cord-001162-z8cbbit3 authors: Yun, Heather C.; Fugate, William H.; Murray, Clinton K.; Cropper, Thomas L.; Lott, Lisa; McDonald, J. Matthew title: Pandemic Influenza Virus 2009 H1N1 and Adenovirus in a High Risk Population of Young Adults: Epidemiology, Comparison of Clinical Presentations, and Coinfection date: 2014-01-08 journal: PLoS One DOI: 10.1371/journal.pone.0085094 sha: doc_id: 1162 cord_uid: z8cbbit3 BACKGROUND: In 2009, pandemic H1N1 influenza virus (2009 H1N1) emerged worldwide, causing morbidity and mortality that disproportionately affected young adults. Despite high frequencies of adenovirus infection, coinfection with adenovirus and 2009 H1N1 is rare and apparently does not result in increased morbidity. keywords: adenovirus; h1n1; illness; influenza; study; subjects; trainees; training cache: cord-001162-z8cbbit3.txt plain text: cord-001162-z8cbbit3.txt item: #113 of 672 id: cord-001186-jkg7qkj6 author: Skowronski, Danuta M. title: Randomized Controlled Ferret Study to Assess the Direct Impact of 2008–09 Trivalent Inactivated Influenza Vaccine on A(H1N1)pdm09 Disease Risk date: 2014-01-27 words: 8888 flesch: 34 summary: Four observational studies from Canada Seasonal influenza vaccine and increased risk of pandemic A/H1N1-related illness: first detection of the association in British Columbia Clinical and epidemiologic characteristics of an outbreak of novel H1N1 (swine origin) influenza A virus among United States military beneficiaries Association between seasonal influenza vaccination in 2008-2009 and pandemic influenza A (H1N1) 2009 infection among school students from Kobe Effectiveness of pandemic H1N1 vaccine against influenza-related hospitalization in children Effectiveness of 2008-09 trivalent influenza vaccine against 2009 pandemic influenza A (H1N1) -United States Notes from the field: outbreak of 2009 pandemic influenza A (H1N1) virus at a large public university in Delaware Pandemic influenza H1N1 2009 infection in Victoria, Australia: no evidence for harm or benefit following receipt of seasonal influenza vaccine in 2009 No association between 2008-09 influenza vaccine and influenza A(H1N1)pdm09 virus infection Partial protection of seasonal trivalent inactivated vaccine against novel pandemic influenza A/H1N1 2009: case control study in Mexico City Infection and deaths from influenza A H1N1 virus in Mexico: a retrospective analysis Protective efficacy of seasonal influenza vaccination against seasonal and pandemic influenza virus infection during 2009 in Hong Kong Mechanism for seasonal vaccine effect on pandemic H1N1 risk remains uncertain Comparison of a live attenuated 2009 H1N1 vaccine with seasonal influenza vaccines against 2009 pandemic H1N1 virus infection in mice and ferrets Seasonal influenza vaccine provides priming for A/H1N1 immunization Assessment of the efficacy of commercially available and candidate vaccines against a pandemic H1N1 2009 virus Impact of prior seasonal influenza vaccination and infection on pandemic A(H1N1) influenza virus replication in ferrets Efficacy of vaccination with different combinations of MF59-adjuvanted and non-adjuvanted seasonal and pandemic influenza vaccines against pandemic H1N1 (2009) influenza virus infection in ferrets Efficacy of seasonal live attenuated influenza vaccine against virus replication and transmission of a pandemic 2009 H1N1 virus in ferrets World Health Organization. WHO recommendations on the composition of influenza virus vaccines Cross-lineage influenza B and heterologous influenza A antibody responses in vaccinated mice: immunologic interactions and B/Yamagata dominance Oseltamivirresistant pandemic A/H1N1 virus is as virulent as its wild-type counterpart in mice and ferrets The 2009 pandemic H1N1 D222G hemagglutinin mutation alters receptor specificity and increases virulence in mice but not in ferrets Global Influenza Surveillance Network Manual for the laboratory diagnosis and virological surveillance of influenza IDEXX product brochure Profiling of humoral immune responses to influenza viruses by using protein microarray Enhanced expression of an alpha2,6-linked sialic acid on MDCK cells improves isolation of human influenza viruses and evaluation of their sensitivity to a neuraminidase inhibitor Enhanced lung disease and Th2 response following human metapneumovirus infection in mice immunized with the inactivated virus Early cytokine mRNA expression profiles predict Morbillivirus disease outcome in ferrets Molecular cloning and phylogenetic analysis of inflammatory cytokines of the ferret (Mustela putorius furo) Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation A new mathematical model for relative quantification in realtime RT-PCR Protective efficacy against pandemic influenza of seasonal influenza vaccination in children in Hong Kong: a randomized controlled trial The ferret as a model organism to study influenza A virus infection Vaccination against human influenza A/H3N2 virus prevents the induction of heterosubtypic immunity against lethal infection with avian influenza A/H5N1 virus Yearly influenza vaccinations: a double-edged sword? Seasonal influenza vaccination and the risk of infection with pandemic influenza: a possible illustration of nonspecific temporary immunity following infection Understanding dengue pathogenesis: implications for vaccine design An in-depth analysis of original antigenic sin in dengue virus infection Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes High titer and avidity of nonneutralizing antibodies against influenza vaccine antigen are associated with severe influenza Failure of protection and enhanced pneumonia with a US H1N2 swine influenza virus in pigs vaccinated with an inactivated classical swine H1N1 vaccine Enhanced pneumonia and disease in pigs vaccinated with an inactivated humanlike (d-cluster) H1N2 vaccine and challenged with pandemic 2009 H1N1 influenza virus Kinetics of lung lesion development and pro-inflammatory cytokine response in pigs with vaccine-associated enhanced respiratory disease induced by challenge with pandemic (2009) keywords: a(h1n1)pdm09; animals; antibody; ch+5; day; ferrets; group; infection; influenza; lung; pandemic; placebo; seasonal; table; tiv; vaccinated; vaccine; virus cache: cord-001186-jkg7qkj6.txt plain text: cord-001186-jkg7qkj6.txt item: #114 of 672 id: cord-001199-9khx93c0 author: Liu, Fengchen title: Effect of the One-Child Policy on Influenza Transmission in China: A Stochastic Transmission Model date: 2014-02-06 words: 6872 flesch: 41 summary: With this model, we simulated 30 years of influenza transmission and compared influenza transmission rates in populations with and without the one-child policy control. The strict onechild policy was introduced to compare influenza transmission rates with a hypothetical one-child policy to rates with an actual one-child policy, since two or more children are often allowed in rural areas and for ethnic minorities [4] ; the existing census data do not reflect the effects of truly restricting families to one child. keywords: attack; child policy; contact; household; individual; influenza; model; population; rate; transmission cache: cord-001199-9khx93c0.txt plain text: cord-001199-9khx93c0.txt item: #115 of 672 id: cord-001207-yjaiybwf author: Sachsenröder, Jana title: The General Composition of the Faecal Virome of Pigs Depends on Age, but Not on Feeding with a Probiotic Bacterium date: 2014-02-19 words: 5923 flesch: 45 summary: Most obvious are age-related differences in the proportion between pig viruses and bacteriophages as well as an increasing diversification of virus species by age. The percentage of detected mammalian virus sequences was highest (55–77%) in the samples of the youngest piglets and lowest (8–10%) in the samples of the sows. keywords: bacteriophages; faecal; faecium; group; piglets; probiotic; reads; samples; sequences; species; virome; viruses cache: cord-001207-yjaiybwf.txt plain text: cord-001207-yjaiybwf.txt item: #116 of 672 id: cord-001213-gxqufddb author: Butt, Azeem Mehmood title: Genome-Wide Analysis of Codon Usage and Influencing Factors in Chikungunya Viruses date: 2014-03-04 words: 7187 flesch: 45 summary: A comparative analysis of RSCU between CHIKV and its hosts showed that codon usage patterns of CHIKV are a mixture of coincidence and antagonism. Studies on codon usage have determined several factors that could influence codon usage patterns, including mutational pressure, natural or translational selection, secondary protein structure, replication and selective transcription, hydrophobicity and hydrophilicity of the protein and the external environment. keywords: analysis; chikv; codon; codon usage; genomes; p,0.01; patterns; usage; values; viruses cache: cord-001213-gxqufddb.txt plain text: cord-001213-gxqufddb.txt item: #117 of 672 id: cord-001219-517gka4h author: Timpka, Toomas title: Intentions to Perform Non-Pharmaceutical Protective Behaviors during Influenza Outbreaks in Sweden: A Cross-Sectional Study following a Mass Vaccination Campaign date: 2014-03-07 words: 5809 flesch: 32 summary: We administered a cross-sectional telephone survey to a representative sample (n = 443) of the Swedish adult population to examine whether self-reported intentions to improve personal hygiene and increase social distancing during influenza outbreaks could be explained by trust in official information, self-reported health (SF-8), sociodemographic factors, and determinants postulated in protection motivation theory, namely threat appraisal and coping appraisal. Protective behavior associated with influenza outbreaks has also been investigated with regard to general estimates of health status [15] , but few studies have used validated measures of self-rated health as a means for the sub categorization. keywords: appraisal; behaviors; health; influenza; intention; model; outbreaks; self; study; threat cache: cord-001219-517gka4h.txt plain text: cord-001219-517gka4h.txt item: #118 of 672 id: cord-001249-awn9ayy6 author: Lasecka, Lidia title: The Nairovirus Nairobi Sheep Disease Virus/Ganjam Virus Induces the Translocation of Protein Disulphide Isomerase-Like Oxidoreductases from the Endoplasmic Reticulum to the Cell Surface and the Extracellular Space date: 2014-04-08 words: 9966 flesch: 43 summary: Statistical analysis of the effect of infection on distribution of host cell proteins was carried out using the chisq.test() function in R. NSDVi-infected cells were harvested with 0.4 ml of a lysis buffer (1% (v/v) Nonidet P-40, 50 mM Tris/Cl pH 7.5, 150 mM NaCl, 2 mM EDTA, 2.5 mM EDTA) containing protease inhibitor cocktail set III (Calbiochem) at a final dilution of 1/200. The underlying mechanism for the redistribution of these soluble ER proteins in NSDV infected cells remains to be determined. keywords: anti; cells; congo; crimean; disease; erp57; fever; figure; fluor; infection; mouse; nsdv; pdi; pregn; protein; rabbit; surface; virus cache: cord-001249-awn9ayy6.txt plain text: cord-001249-awn9ayy6.txt item: #119 of 672 id: cord-001251-forh7lw4 author: Jank, Johanna M. title: The Domain-Specific and Temperature-Dependent Protein Misfolding Phenotype of Variant Medium-Chain acyl-CoA Dehydrogenase date: 2014-04-09 words: 7802 flesch: 40 summary: Based on visual analysis of side-chain replacements in the MCAD 3D structure, one would judge mutations p.Tyr67His, p.Arg206Cys, p.Asp266Gly, and p.Arg413Ser, all affecting protein surface regions, as not damaging. Moreover, mutations p.Tyr67His and p.Lys329Glu displayed similar behavior with respect to various parameters of protein conformation and stability. keywords: acadm; acyl; chain; coa; fad; mcad; mutations; p.lys329glu; p.tyr67his; protein; stability; thermal; type; variant cache: cord-001251-forh7lw4.txt plain text: cord-001251-forh7lw4.txt item: #120 of 672 id: cord-001253-3jnkki5z author: Mohammad, Fahim title: Advantages and Limitations of Anticipating Laboratory Test Results from Regression- and Tree-Based Rules Derived from Electronic Health-Record Data date: 2014-04-14 words: 3857 flesch: 48 summary: We analyzed 10 years of electronic health records—a total of 69.4 million blood tests—to see how well standard rule-mining techniques can anticipate test results based on patient age and gender, recent diagnoses, and recent laboratory test results. In a sense, contingency is a form of selection bias: there may well be other diagnoses or test result results that correlate with the result for the test of interest that are not routinely measured according to current best practices. keywords: data; glm; laboratory; result; rules; set; test cache: cord-001253-3jnkki5z.txt plain text: cord-001253-3jnkki5z.txt item: #121 of 672 id: cord-001254-y2knt8g0 author: Parkhomenko, Taisiya A. title: Comparison of DNA-Hydrolyzing Antibodies from the Cerebrospinal Fluid and Serum of Patients with Multiple Sclerosis date: 2014-04-15 words: 6771 flesch: 46 summary: An additional question is why there is no good correlation between various indexes, characterizing different MS patients. Recently we have shown that IgGs from the sera of MS patients are active in the hydrolysis of DNA. keywords: abs; activity; csf; dna; dnase; iggs; patients; protein; sera; serum; total cache: cord-001254-y2knt8g0.txt plain text: cord-001254-y2knt8g0.txt item: #122 of 672 id: cord-001263-hqxiyxfj author: Kam, Yiu-Wing title: Unique Epitopes Recognized by Antibodies Induced in Chikungunya Virus-Infected Non-Human Primates: Implications for the Study of Immunopathology and Vaccine Development date: 2014-04-22 words: 5686 flesch: 42 summary: Although patient cohort studies have shown the production of CHIKV specific antibodies, the fine specificity of the antibody response against CHIKV is not completely defined. Arrows at the middle panel (non-structural proteins) and the lower panel (structural proteins) indicate CHIKV proteins detected by corresponding CHIKV antigen-specific rabbit sera performed at a dilution of 1:2,000 followed by HRP-conjugated anti-rabbit IgG secondary antibodies. keywords: antibodies; chikungunya; chikv; epitopes; figure; glycoprotein; infection; macaques; proteins; sera; serum; virus cache: cord-001263-hqxiyxfj.txt plain text: cord-001263-hqxiyxfj.txt item: #123 of 672 id: cord-001275-a9o2dvke author: Chen, Xue title: A Vaccine of L2 Epitope Repeats Fused with a Modified IgG1 Fc Induced Cross-Neutralizing Antibodies and Protective Immunity against Divergent Human Papillomavirus Types date: 2014-05-06 words: 5577 flesch: 41 summary: 16-26 years HPV16/ 18 L1 VLP vaccine induces cross-neutralizing antibodies that may mediate cross-protection Protection against heterologous human papillomavirus challenge by a synthetic lipopeptide vaccine containing a broadly cross-neutralizing epitope of L2 Protection of rabbits against challenge with rabbit papillomaviruses by immunization with the N terminus of human papillomavirus type 16 minor capsid antigen L2 Type-specific and cross-reactive antibodies induced by human papillomavirus 31 L1/L2 virus-like particles Mechanisms of human papillomavirus type 16 neutralization by l2 cross-neutralizing and l1 type-specific antibodies Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection Potent anti-HPV immune responses induced by tandem repeats of the HPV16 L2 (20 -38) peptide displayed on bacterial thioredoxin The N-terminal region of the human papillomavirus L2 protein contains overlapping binding sites for neutralizing, cross-neutralizing and non-neutralizing antibodies Neutralization of HPV16, 18, 31, and 58 pseudovirions with antisera induced by immunizing rabbits with synthetic peptides representing segments of the HPV16 minor capsid protein L2 surface region Monoclonal antibodies recognizing cross-neutralization epitopes in human papillomavirus 16 minor capsid protein L2 Crossneutralization potential of native human papillomavirus N-terminal L2 epitopes A protective and broadly cross-neutralizing epitope of human papillomavirus L2 Minor capsid protein of human genital papillomaviruses contains subdominant, crossneutralizing epitopes Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells Transport of immune complexes from the subcapsular sinus to lymph node follicles on the surface of nonphagocytic cells, including cells with dendritic morphology B cell recognition of membrane-bound antigen: an exquisite way of sensing ligands Taking dendritic cells into medicine A papillomavirus-like particle (VLP) vaccine displaying HPV16 L2 epitopes induces cross-neutralizing antibodies to HPV11 Chimeric L1-L2 virus-like particles as potential broad-spectrum human papillomavirus vaccines Efficacy of RG1-VLP Vaccination against Infections with Genital and Cutaneous Human Papillomaviruses VLPs displaying a single L2 epitope induce broadly cross-neutralizing antibodies against human papillomavirus A universal virus-like particle-based vaccine for human papillomavirus: longevity of protection and role of endogenous and exogenous adjuvants Development of AAVLP(HPV16/31L2) particles as broadly protective HPV vaccine candidate A recombinant mimetics of the HIV-1 gp41 prehairpin fusion intermediate fused with human IgG Fc fragment elicits neutralizing antibody response in the vaccinated mice HIV-1 and influenza antigens synthetically linked to IgG2a Fc elicit superior humoral responses compared to unmodified antigens in mice Efficient mucosal vaccination mediated by the neonatal Fc receptor A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses Ebola virus glycoprotein Fc fusion protein confers protection against lethal challenge in vaccinated mice A novel Fc gamma receptor ligand augments humoral responses by targeting antigen to Fc gamma receptors Rapid immune responses to a botulinum neurotoxin Hc subunit vaccine through in vivo targeting to antigen-presenting cells Localization of the binding site for the human high-affinity Fc receptor on IgG Human Fc gamma RI and Fc gamma RII interact with distinct but overlapping sites on human IgG Trivalent Human Papillomavirus (HPV) VLP vaccine covering HPV type 58 can elicit high level of humoral immunity but also induce immune interference among component types Human papillomavirus type 58 L1 virus-like particles purified by two-step chromatography elicit high levels of long-lasting neutralizing antibodies Efficient intracellular assembly of papillomaviral vectors Generation of HPV pseudovirions using transfection and their use in neutralization assays Optimization of multimeric human papillomavirus L2 vaccines Concatenated multitype L2 fusion proteins as candidate prophylactic panhuman papillomavirus vaccines Immunization with potato plants expressing VP60 protein protects against rabbit hemorrhagic disease virus Differential antibody responses to a distinct region of human papillomavirus minor capsid proteins Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine Surface display of IgG Fc on baculovirus vectors enhances binding to antigen-presenting cells and cell lines expressing Fc receptors Crossreactive HIV-1-neutralizing activity of serum IgG from a rabbit immunized with gp41 fused to IgG1 Fc: possible role of the prolonged half-life of the immunogen Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA with adjuvant monophosphoryl lipid To measure cross-reactive antibody responses to HPV capsids in antisera, ELISA plates were coated with 1.5610 4 to 2.0610 4 IU of HPV PsVs (depending on the PsV stock) encoding GFP. keywords: antibodies; antibody; cross; hpv; hpv16; human; mice; papillomavirus; protein; responses; types cache: cord-001275-a9o2dvke.txt plain text: cord-001275-a9o2dvke.txt item: #124 of 672 id: cord-001280-skavefji author: Choi, Sang-Ho title: Usefulness of Cellular Analysis of Bronchoalveolar Lavage Fluid for Predicting the Etiology of Pneumonia in Critically Ill Patients date: 2014-05-13 words: 4139 flesch: 31 summary: For positiveand negative predictive values, the prevalence of bacterial pneumonia in severe pneumonia patients admitted to the medical ICU was assumed to be 35.9%, based on our previous study [14] . By using strict enrollment criteria, however, only a small proportion of pneumonia patients who underwent bronchoscopic BAL was finally included (Figure 1 ), which might have influenced on the results. keywords: analysis; bal; fluid; patients; pneumonia; total; wbc cache: cord-001280-skavefji.txt plain text: cord-001280-skavefji.txt item: #125 of 672 id: cord-001343-3euy4u9k author: Wang, Yadong title: A Multi-Method Approach to Curriculum Development for In-Service Training in China’s Newly Established Health Emergency Response Offices date: 2014-06-27 words: 4089 flesch: 38 summary: We assessed tasks, roles and responsibilities, and training needs of HERO staff through face-to-face interviews of eleven experienced key informants; they included health emergency experts from the government, the military and the academic sector, and senior staff of HEROs. At the global level, perennial threats of the pandemic spread of infectious diseases like SARS and influenza, as well as the sequelae of earthquakes, tsunamis, bioterrorism and complex humanitarian emergencies, heightened awareness of the need to strengthen national, regional and global capacity in prevention, preparedness and response to public health emergencies. keywords: china; curriculum; development; emergency; health; knowledge; response; staff; training cache: cord-001343-3euy4u9k.txt plain text: cord-001343-3euy4u9k.txt item: #126 of 672 id: cord-001359-c1uom5f7 author: Oslund, Karen L. title: Synergistic Up-Regulation of CXCL10 by Virus and IFN γ in Human Airway Epithelial Cells date: 2014-07-17 words: 4573 flesch: 47 summary: following infection with the MEM influenza virus and treatment with IFN c. CXCL10 induction was also significantly elevated following the combined treatment of MEM and IFN c treatment as compared to the treatment with IFN c alone. In summary, we demonstrate IFN c and the influenza virus synergistically induce CXCL10 in human airway epithelial cells. keywords: cells; cxcl10; dsrna; human; ifn; ifnar; induction; treatment cache: cord-001359-c1uom5f7.txt plain text: cord-001359-c1uom5f7.txt item: #127 of 672 id: cord-001363-irysq6pf author: Liu, Zhenjiang title: SELDI-TOF-MS Proteomic Profiling of Serum, Urine, and Amniotic Fluid in Neural Tube Defects date: 2014-07-23 words: 5121 flesch: 42 summary: [34, 42] , and has many other advantages compared with traditional approaches: 1) it is much faster to perform; 2) it has high-throughput capability; 3) it requires only small amount of protein sample; 4) it has relatively high sensitivity to detect proteins at picomole to attamole range; 5) it can effectively resolve low mass proteins (2-20 KDa) and 6) it is directly applicable for development of clinical assays Second Report of the Collaborative Acetylcholinesterase Study Differential expression of proteomics models of colorectal cancer, colorectal benign disease and healthy controls Identification of serum proteins as prognostic and predictive markers of colorectal cancer using surface enhanced laser desorption ionization-time of flight mass spectrometry Identification of serum biomarkers for pancreatic adenocarcinoma by proteomic analysis Discovery of serum biomarkers for pancreatic adenocarcinoma using proteomic analysis The complement component C3a fragment is a potential biomarker for hepatitis C virus-related hepatocellular carcinoma Identification of beta2-microgloblin as a candidate for early diagnosis of imaging-invisible hepatocellular carcinoma in patient with liver cirrhosis Identification of candidate molecular markers predicting chemotherapy resistance in non-small cell lung cancer Identification of a 17-protein signature in the serum of lung cancer patients Improving Detection Accuracy of Lung Cancer Serum Proteomic Profiling via Two-Stage Training Process Enriched sera protein profiling for detection of non-small cell lung cancer biomarkers Detection and identification of potential biomarkers of breast cancer keywords: control; fluid; mothers; ntd; ntds; peaks; samples; serum; urine cache: cord-001363-irysq6pf.txt plain text: cord-001363-irysq6pf.txt item: #128 of 672 id: cord-001368-ymp1pj3r author: Zhang, Chao title: Recombinant Scorpine Produced Using SUMO Fusion Partner in Escherichia coli Has the Activities against Clinically Isolated Bacteria and Inhibits the Plasmodium falciparum Parasitemia In Vitro date: 2014-07-28 words: 4445 flesch: 44 summary: Thus, the expression strategy presented in this study allowed convenient high yield and easy purification of recombinant Scorpine for pharmaceutical applications in the future. To measure effects of recombinant Scorpine on the growth of bacteria planktonic cell, the bacteria were transferred into 96-well flat-bottomed polystyrene microtiter plates (BD Falcon, SanJose, CA, USA) at approximately 10 5 CFU/ml in tryptic soy broth (TSB) in the presence of recombinant Scorpine (5 and 10 mM) and cultured at 37uC for 24 h under static conditions, aerobically. keywords: aureus; bacteria; baumannii; biofilm; coli; expression; fusion; protein; scorpine; sumo cache: cord-001368-ymp1pj3r.txt plain text: cord-001368-ymp1pj3r.txt item: #129 of 672 id: cord-001383-hww0watl author: Li, Wenchao title: Self-Assembly and Release of Peste des Petits Ruminants Virus-Like Particles in an Insect Cell-Baculovirus System and Their Immunogenicity in Mice and Goats date: 2014-08-12 words: 6565 flesch: 41 summary: No N protein-specific antibodies were found in goats vaccinated with PPRV H or PPRV F VLPs; in contrast, seroconversion to N protein was detected in goats vaccinated with the PPRV Nig 75/1 attenuated virus (data not shown). To date, the assembly and release of PPRV VLPs have not been well characterized, and their immunogenicity remains unknown. keywords: baculovirus; cells; expression; goats; h vlps; insect; mice; particles; pprv; protein; ruminants; virus; vlps cache: cord-001383-hww0watl.txt plain text: cord-001383-hww0watl.txt item: #130 of 672 id: cord-001387-2g9dc5z4 author: McIntyre, K. Marie title: A Quantitative Prioritisation of Human and Domestic Animal Pathogens in Europe date: 2014-08-19 words: 4582 flesch: 33 summary: Finally, the acceptability of the H-index proxy for animal pathogen impact was examined by comparison with other measures. There were statistically significant differences between H-indices for host types (humans, animal, zoonotic), and there was limited evidence that H-indices are a reasonable proxy for animal pathogen impact. keywords: animal; disease; health; human; impact; index; indices; list; pathogens; zoonotic cache: cord-001387-2g9dc5z4.txt plain text: cord-001387-2g9dc5z4.txt item: #131 of 672 id: cord-001420-b4zcvd04 author: Crescenzo-Chaigne, Bernadette title: Chimeric NP Non Coding Regions between Type A and C Influenza Viruses Reveal Their Role in Translation Regulation date: 2014-09-30 words: 6277 flesch: 49 summary: A virus nucleoprotein required for viral polymerase binding and RNA synthesis Interaction of the influenza a virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication Isolation of a novel swine influenza virus from Oklahoma in 2011 which is distantly related to human influenza C viruses Clinical features of influenza C virus infection in children Influenza C virus uses 9-O-acetyl-N-acetylneuraminic acid as a high affinity receptor determinant for attachment to cells Comparison of the three large polymerase proteins of influenza A, B, and C viruses Comparative analysis of the ability of the polymerase complexes of influenza viruses type A, B and C to assemble into functional RNPs that allow expression and replication of heterotypic model RNA templates in vivo A plasmid-based reverse genetics system for influenza A virus A molecular mechanism of complement resistance of human melanoma cells Genetic analysis of animal viruses. For the 39 and 59 ends, respectively, the conserved sequences are 12 and 13 nt for type A and 11 and 12 nt for type C influenza viruses [3, 4, 5] . keywords: end; genetics; influenza; panhandle; rna; segment; type; type c; virus; viruses cache: cord-001420-b4zcvd04.txt plain text: cord-001420-b4zcvd04.txt item: #132 of 672 id: cord-001421-6t5puo6p author: Marfà, Santiago title: Lack of a 5.9 kDa Peptide C-Terminal Fragment of Fibrinogen α Chain Precedes Fibrosis Progression in Patients with Liver Disease date: 2014-10-02 words: 5059 flesch: 42 summary: Fibrosis scores and liver function tests of the two groups of fibrotic patients were similar to those obtained in HCV LT patients. The methods currently available to assess liver fibrosis include the serological determination of several parameters related to liver function and hepatic remodeling, imaging techniques, such as Fibroscan or ARFI and the use of invasive procedures such as HVPG measurement or liver biopsy, the latter still being the most widely accepted gold standard method for assessing liver fibrosis [9] . keywords: fibrinogen; fibrosis; hcv; kda; liver; non; patients; peak; protein; recurrent; samples; serum cache: cord-001421-6t5puo6p.txt plain text: cord-001421-6t5puo6p.txt item: #133 of 672 id: cord-001432-d4zavkcn author: Nishida, Yoriko title: Antibody-Validated Proteins in Inflamed Islets of Fulminant Type 1 Diabetes Profiled by Laser-Capture Microdissection Followed by Mass Spectrometry date: 2014-10-16 words: 5292 flesch: 41 summary: Probable ATP-dependent RNA helicase DEAD box helicase 5 (DDX5) was over-expressed in the nucleus and cytoplasm of all subsets of islet cells affected by FT1DM ( Figure 2G ). Serpin B6 (SERPINB6) was strongly expressed both in islet cells and exocrine cells in FT1DM-affected tissues but was only weakly expressed in non-diabetic control tissues. keywords: beta; cells; control; diabetes; expression; figure; ft1dm; ifn; islets; pancreas; proteins; tissue; type cache: cord-001432-d4zavkcn.txt plain text: cord-001432-d4zavkcn.txt item: #134 of 672 id: cord-001435-ebl8yc92 author: Hoppe, Sebastian title: Identification of Antigenic Proteins of the Nosocomial Pathogen Klebsiella pneumoniae date: 2014-10-21 words: 9628 flesch: 46 summary: The structure of bacterial outer membrane proteins Identification and characterization of ompl as a potential vaccine candidate for immune-protection against salmonellosis in mice The unique structure of Haemophilus influenzae protein E reveals multiple binding sites for host factors Directed evaluation of enterotoxigenic Escherichia coli autotransporter proteins as putative vaccine candidates Structure of the c-terminal domain of Neisseria heparin binding antigen (nhba), one of the main antigens of a novel vaccine against Neisseria meningitidis In vivo versus in vitro protein abundance analysis of Shigella dysenteriae type 1 reveals changes in the expression of proteins involved in virulence, stress and energy metabolism Surface expression, singlechannel analysis and membrane topology of recombinant Chlamydia trachomatis major outer membrane protein Predicting transmembrane protein topology with a hidden markov model: application to complete genomes A hidden markov model for predicting transmembrane helices in protein sequences A semi-empirical method for prediction of antigenic determinants on protein antigens New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and x-ray-derived accessible sites Toward the estimation of the absolute quality of individual protein structure models The rin: an rna integrity number for assigning integrity values to rna measurements Gene expression omnibus: Protein expression, lysis, and spotting of fulllength proteins were performed as described above. keywords: a.u; alanine; antibodies; antibody; cdna; epitope; linear; min; model; pcr; peptides; pneumoniae; position; proteins; reaction; sequence; specificity cache: cord-001435-ebl8yc92.txt plain text: cord-001435-ebl8yc92.txt item: #135 of 672 id: cord-001446-mpuovmeb author: Bratcher, Preston E. title: Factors Influencing the Measurement of Plasma/Serum Surfactant Protein D Levels by ELISA date: 2014-11-03 words: 4876 flesch: 37 summary: Integrating lung and plasma expression of pneumo-proteins in developing biomarkers in COPD: a case study of surfactant protein D Ageing and smoking contribute to plasma surfactant proteins and protease imbalance with correlations to airway obstruction Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease Budesonide/formoterol enhances the expression of pro Surfactant Protein-B in lungs of COPD patients Exhaled metallic elements and serum pneumoproteins in asymptomatic smokers and patients with COPD or asthma Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study The effects of fluticasone with or without salmeterol on systemic biomarkers of inflammation in chronic obstructive pulmonary disease Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD Serum surfactant protein D during acute exacerbations of chronic obstructive pulmonary disease Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD Serum surfactant protein D: biomarker of chronic obstructive pulmonary disease Value of serum and induced sputum surfactant protein-D in chronic obstructive pulmonary disease Surfactant protein d, soluble intercellular adhesion molecule-1 and highsensitivity C-reactive protein as biomarkers of chronic obstructive pulmonary disease The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema Surfactant protein D in serum from patients with allergic bronchopulmonary aspergillosis Serum-surfactant SP-D correlates inversely to lung function in cystic fibrosis Circulating surfactant protein-D and the risk of cardiovascular morbidity and mortality The utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on-and off-pump coronary bypass surgery Can serum surfactant protein D or CC-chemokine ligand 18 predict outcome of interstitial lung disease in patients with early systemic sclerosis? Serum levels of surfactant proteins A and D are useful biomarkers for interstitial lung disease in patients with progressive systemic sclerosis Clinical significance of surfactant protein D as a serum marker for evaluating pulmonary fibrosis in patients with systemic sclerosis Comparative study of serum surfactant protein-D and KL-6 concentrations in patients with systemic sclerosis as markers for monitoring the activity of pulmonary fibrosis Surfactant protein D and KL-6 as serum biomarkers of interstitial lung disease in patients with scleroderma Clinical significance of serum pulmonary surfactant proteins a and d for the early detection of radiation pneumonitis Diagnostic significance of surfactant proteins A and D in sera from patients with radiation pneumonitis Study of Clara cell 16, KL-6, and surfactant protein-D in serum as disease markers in pulmonary sarcoidosis Serum surfactant protein D is elevated in allergic patients Involvement of eicosanoids and surfactant protein D in extrinsic allergic alveolitis Functional and biological characteristics of asthma in cleaning workers Circulating surfactant protein D is decreased in early rheumatoid arthritis: a 1-year prospective study Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis Elevated plasma surfactant protein D (SP-D) levels and a direct correlation with anti-severe acute respiratory syndrome coronavirus-specific IgG antibody in SARS patients Analysis of plasma surfactant protein D levels in lung transplant recipients Clinical significance of the serum surfactant protein D and KL-6 levels in patients with measles complicated by interstitial pneumonia Surfactant protein D (SP-D) serum levels in patients with community-acquired pneumonia small star, filled Serum SP-D levels as a biomarker of lung injury in respiratory syncytial virus bronchiolitis Serum KL-6 and surfactant protein D in children with 2009 pandemic H1N1 influenza infection Serum KL-6 and surfactant proteins A and D in pediatric interstitial lung disease Polymorphisms in the human surfactant protein-D (SFTPD) gene: strong evidence that serum levels of surfactant protein-D (SP-D) are genetically influenced Surfactant protein d, a marker of lung innate immunity, is positively associated with insulin sensitivity Circulating levels of Clara cell protein 16 but not surfactant protein D identify and quantify lung damage in patients with multiple injuries Blood biomarkers and measures of pulmonary function-a study from the Swedish twin registry Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice Long-term stability and circadian variation in circulating levels of surfactant protein D A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D Plasma surfactant protein D levels and the relation to body mass index in a chinese population Plasma C3d levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings Respiratory effects associated with wood fuel use: a cross-sectional biomarker study among adolescents Roles of serum clara cell protein 16 and surfactant protein-D in the early diagnosis and progression of silicosis Serum surfactant protein-A, but not surfactant protein-D or KL-6, can predict preclinical lung damage induced by smoking Biomarkers of early respiratory effects in smoking adolescents Circulating markers of interstitial lung disease and subsequent risk of lung cancer Inhaled LPS challenges in smokers: a study of pulmonary and systemic effects Lung epithelium injury biomarkers in workers exposed to sulphur dioxide in a nonferrous smelter The effects of GH and hormone replacement therapy on serum concentrations of mannan-binding lectin, surfactant protein D and vitamin D binding protein in Turner syndrome Plasma surfactant D in patients following acute paraquat intoxication Respiratory function and changes in lung epithelium biomarkers after a short-training intervention in chlorinated vs. ozone indoor pools A panel of lung injury biomarkers enhances the definition of primary graft dysfunction (PGD) Surfactant protein D in atopic dermatitis and psoriasis Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury Effects of leukoreduced blood on acute lung injury after trauma: a randomized controlled trial Surfactant phospholipids, surfactant proteins, and inflammatory markers during acute lung injury in children Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury Plasma CC16 levels are associated with development of ALI/ARDS in patients with ventilator-associated pneumonia: a retrospective observational study Plasma levels of surfactant protein D and KL-6 for evaluation of lung injury in critically ill mechanically ventilated patients Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome Serum surfactant proteins-A and -D as biomarkers in idiopathic pulmonary fibrosis Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS Increased plasma concentration of surfactant protein D in chronic periodontitis independent of SFTPD genotype: potential role as a biomarker Effect of single vs bilateral lung transplantation on plasma surfactant protein D levels in idiopathic pulmonary fibrosis Pulmonary surfactant protein D in sera and bronchoalveolar lavage fluids Enzymelinked immunosorbent assay using F(ab')2 fragment for the detection of human pulmonary surfactant protein D in sera Comparative study of KL-6, surfactant protein-A, surfactant protein-D, and monocyte chemoattractant protein-1 as serum markers for interstitial lung diseases Increased circulating levels of soluble Fas ligand are correlated with disease activity in patients with fibrosing lung diseases Monitoring markers of disease activity for interstitial lung diseases with serum surfactant proteins A and D Clinical importance of bronchoalveolar lavage fluid and blood cytokines, surfactant protein D, and Kerbs von Lungren 6 antigen in idiopathic pulmonary alveolar proteinosis Significance of serum vascular endothelial growth factor level in patients with idiopathic pulmonary fibrosis Pneumocyte biomarkers KL-6 and surfactant protein D reflect the distinct findings of high-resolution computed tomography in nonspecific interstitial pneumonia keywords: antibody; elisa; levels; lung; plasma; protein; serum; surfactant cache: cord-001446-mpuovmeb.txt plain text: cord-001446-mpuovmeb.txt item: #136 of 672 id: cord-001447-oi7bkm4z author: Dhanasekaran, Sakthivel title: Toll-Like Receptor Responses to Peste des petits ruminants Virus in Goats and Water Buffalo date: 2014-11-04 words: 6018 flesch: 43 summary: Peste des petits ruminants Prevalence and distribution of peste des petits ruminants virus infection in small ruminants in India Global distribution of peste des petits ruminants virus and prospects for improved diagnosis and control The detection of antibody against peste des petits ruminants virus in sheep, goats, cattle and buffaloes Isolation of pestes des petits ruminants virus from an outbreak in Indian buffalo (Bubalus bubalis) Current situation of Peste des petits ruminants (PPR) in the Sudan Peste des petits ruminants in Ethiopian goats The isolation of peste des petits ruminants virus from Nigerian sheep and goats Peste des petits ruminants has been widely present in southern India since, if not before, the late 1980s Peste des petits ruminants outbreak in western Turkey Evaluation of the virulence of some strains of peste-des-petits-ruminants virus (PPRV) in experimentally infected West African dwarf goats Evaluation of novel diagnostic tools for peste des petits ruminants virus in naturally infected goat herds The pathogenicity of bovine strains of foot-and-mouth disease virus for impala and wildebeest The 40-corrected Ct values of TLR3 and TLR7 mRNA, fold changes in the ligand induced cytokine mRNA expression, PPRV H gene levels and virus yield estimated by TCID 50 determination was compared by two-way ANOVA with Bonferroni test for multiple comparisons. keywords: breeds; buffalo; des; expression; goats; infection; levels; pbmc; peste; pprv; replication; ruminants; tlr7; virus cache: cord-001447-oi7bkm4z.txt plain text: cord-001447-oi7bkm4z.txt item: #137 of 672 id: cord-001455-n7quwr4s author: Rapin, Noreen title: Activation of Innate Immune-Response Genes in Little Brown Bats (Myotis lucifugus) Infected with the Fungus Pseudogymnoascus destructans date: 2014-11-12 words: 3724 flesch: 45 summary: Although damage caused by the fungus is restricted to the superficial skin, infected bats clearly show signs of systemic physiological perturbation such as dehydration, hypovolemia and metabolic acidosis [24] . Infected bats arouse from torpor more frequently than uninfected bats [25, 26] possibly leading to emaciation. keywords: bats; destructans; fungal; genes; infection; levels; lucifugus; pcr; response; transcripts cache: cord-001455-n7quwr4s.txt plain text: cord-001455-n7quwr4s.txt item: #138 of 672 id: cord-001460-eo2bxxbq author: Padhi, Siladitya title: Atomistic Detailed Mechanism and Weak Cation-Conducting Activity of HIV-1 Vpu Revealed by Free Energy Calculations date: 2014-11-13 words: 6679 flesch: 51 summary: Furthermore, unlike transporters, ion channels do not usually undergo large scale domain motions during the process of solute transport, since they undergo gating prior to solute transport [66] . (TIF) Identification of a protein encoded by the vpu gene of HIV-1 A novel gene of HIV-1, vpu, and its 16-kilodalton product Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein HIV-1 accessory proteins-ensuring viral survival in a hostile environment Misdirection of membrane trafficking by HIV-1 Vpu and Nef Viral proteins function as ion channels Viral channel forming proteins-modeling the target HIV-1 Vpu-an ion channel in search of a job Viral channel proteins in intracellular protein-protein communication: Vpu of HIV-1, E5 of HPV16 and p7 of HCV Structural modeling of Vpu from HIV-1 based on solid-state NMR observables Solution structure of the hydrophilic region of HIV-1 encoded virus protein U (Vpu) by CD and 1H NMR spectroscopy Solution structure of the cytoplasmic domain of the human immunodeficiency virus type 1 encoded virus protein U (Vpu) keywords: channel; energy; ion; ion channel; ions; pore; protein; region; vpu cache: cord-001460-eo2bxxbq.txt plain text: cord-001460-eo2bxxbq.txt item: #139 of 672 id: cord-001537-i34vmfpp author: Lima, Francisco Esmaile de Sales title: Genomic Characterization of Novel Circular ssDNA Viruses from Insectivorous Bats in Southern Brazil date: 2015-02-17 words: 3883 flesch: 46 summary: Sequence analyses were performed with the BLASTX software (http://www.ncbi.nlm.nih.gov/blast/). Pan-reactive primers were used targeting the conserved rep region of circoviruses and cycloviruses to screen DNA bat fecal samples. keywords: batcv; bats; cap; circoviruses; cyclovirus; dna; genomes; rep; samples; sequences cache: cord-001537-i34vmfpp.txt plain text: cord-001537-i34vmfpp.txt item: #140 of 672 id: cord-001546-ndz3oarf author: Ayithan, Natarajan title: Virus-Like Particles Activate Type I Interferon Pathways to Facilitate Post-Exposure Protection against Ebola Virus Infection date: 2015-02-26 words: 5132 flesch: 47 summary: Lines of evidence support the critical importance of type I IFN signaling in providing resistance against EBOV infection; mice deficient in Stat1, a transcription factor required for IFN induction, or Ifnar1, encoding the membrane receptor for type I IFNs, are susceptible to wild type Zaire EBOV, against which wild type mice are resistant Mouse-adapted EBOV causes similar acute disease in mice, offering a useful animal model to study EBOV infection keywords: ebov; ifn; ifnar; induction; infection; mice; protection; signaling; type; virus; vlps cache: cord-001546-ndz3oarf.txt plain text: cord-001546-ndz3oarf.txt item: #141 of 672 id: cord-001571-drcfdv9z author: Alvarez, Julio title: Impact of Porcine Epidemic Diarrhea on Performance of Growing Pigs date: 2015-03-13 words: 3103 flesch: 53 summary: Pig batches produced by the 18 flows that broke with PED during the study period (March 2013-June 2014) in the 120 days before the first PED+ batch. To evaluate the effect of PEDv infection on mortality and performance, a retrospective cohort study was carried out in which the exposed group was the first PED-positive batch from a given flow (infected batch) and the unexposed group (control batch) was defined as the batch that had left the sow farm immediately before the exposed group. keywords: batches; mortality; pedv; pigs; sow cache: cord-001571-drcfdv9z.txt plain text: cord-001571-drcfdv9z.txt item: #142 of 672 id: cord-001599-pfdnmzx2 author: Wee, Yin Shen title: Age-Related Onset of Obesity Corresponds with Metabolic Dysregulation and Altered Microglia Morphology in Mice Deficient for Ifitm Proteins date: 2015-04-09 words: 6021 flesch: 39 summary: Analysis of the gene expression profiles in the hypothalamus of IfitmDel animals, compared to WT, demonstrated an altered ratio of Pomc and Npy neuropeptide expression, which likely impairs the satiation response of the IfitmDel animal leading to an increased eating behavior. Anatomical analysis of the hypothalamus using immunohistochemistry revealed that microglia exhibit an abnormal morphology in IfitmDel animals and respond abnormally to Poly:IC challenge. keywords: animals; blood; cells; expression; fig; hypothalamus; ifitmdel; leptin; levels; mice; microglia; poly; proteins cache: cord-001599-pfdnmzx2.txt plain text: cord-001599-pfdnmzx2.txt item: #143 of 672 id: cord-001601-tsuz3j40 author: Ngan, Luong Thi My title: Antiviral Activity and Possible Mechanism of Action of Constituents Identified in Paeonia lactiflora Root toward Human Rhinoviruses date: 2015-04-10 words: 6176 flesch: 47 summary: In the presence of 100 μg/mL PA or 20 μg/mL PGG in MRC5 cell cultures infected with HRV-2, the RNA replication levels were reduced by 30.1 and 14.3 fold, respectively, compared to the levels in the cell cultures without the compounds (Fig 4A) . The findings indicated that these constituents interfered with host cell protein expression of this receptor through inhibition of the receptor RNA expression or reduction of HRV replication. keywords: cells; cultures; expression; hrv; human; icam-1; infection; mrc5; pgg; treatment; virus cache: cord-001601-tsuz3j40.txt plain text: cord-001601-tsuz3j40.txt item: #144 of 672 id: cord-001603-vlv8x8l8 author: Ul-Haq, Zaheer title: 3D Structure Prediction of Human β1-Adrenergic Receptor via Threading-Based Homology Modeling for Implications in Structure-Based Drug Designing date: 2015-04-10 words: 5607 flesch: 47 summary: A new era in the treatment of heart failure Pharmacogenetics of the human beta-adrenergic receptors Predicting molecular interactions in silico: I. A guide to pharmacophore identification and its applications to drug design Virtual screening for SARS-CoV protease based on KZ7088 pharmacophore points Structure-based 3D-QSAR models and dynamics analysis of novel N-benzyl pyridinone as p38α MAP kinase inhibitors for anticytokine activity ClustalW and Clus-talX version 2.0 Comparison of composer and ORCHESTRAR SYBYL Molecular Modeling Software version 7.3, Tripos Associates I-TASSER: a unified platform for automated protein structure and function prediction PROCHECK: a program to check the stereochemical quality of protein structures VERIFY3D: assessment of protein models with three-dimensional profiles Verification of protein structures: patterns of nonbonded atomic interactions Surflex: fully automatic flexible molecular docking using a molecular similarity-based search engine FRED pose prediction and virtual screening accuracy GOLD version 3.0. Salt bridges play important roles in protein structure and function. keywords: alignment; binding; docking; drug; homology; hsβadr1; ligand; model; protein; receptor; residues; sequence; structure cache: cord-001603-vlv8x8l8.txt plain text: cord-001603-vlv8x8l8.txt item: #145 of 672 id: cord-001605-8p06bpt1 author: Sapmak, Ariya title: The pbrB Gene Encodes a Laccase Required for DHN-Melanin Synthesis in Conidia of Talaromyces (Penicillium) marneffei date: 2015-04-13 words: 5186 flesch: 48 summary: T. marneffei cells have been shown to become melanized in vivo. In the absence of tricyclazole, T. marneffei conidia appeared green ( Fig 1B) . keywords: conidia; dhn; fig; fumigatus; fungal; gene; marneffei; melanin; pbrb; strain cache: cord-001605-8p06bpt1.txt plain text: cord-001605-8p06bpt1.txt item: #146 of 672 id: cord-001620-yy5gq0ki author: Woo, Hye-Min title: Isolation of Single-Stranded DNA Aptamers That Distinguish Influenza Virus Hemagglutinin Subtype H1 from H5 date: 2015-04-22 words: 3945 flesch: 44 summary: In vitro selection of ssDNA aptamers specific for H1-HA1 rather than H5-HA1, and determination of binding affinity To select specific ssDNA aptamers that can distinguish H1-HA1 from H5-HA1, counter-SELEX was performed with an ssDNA library of 88-mers containing a randomized sequence region of 45 nucleotides in the center, followed by lambda exonuclease digestion, as shown in Fig 1A. Enrichment of selected ssDNA aptamers specific for H1-HA1 protein was assessed by ELISA on the basis of the interaction between H1-HA1 protein and biotinylated ssDNA aptamers. To confirm the selectivity of ssDNA aptamers, HEK293T cells were harvested with trypsin-EDTA, washed three times with 1 mL of PBS, added to a pre-incubated protein-aptamer complex of 100 μg GST-H1-HA1 protein and 8 μg FITC-labeled aptamer in PBS, and incubated at 4°C for 30 min. keywords: aptamers; binding; gst; ha1; influenza; protein; ssdna; virus cache: cord-001620-yy5gq0ki.txt plain text: cord-001620-yy5gq0ki.txt item: #147 of 672 id: cord-001639-p9mbmfaq author: Alfonso-Morales, Abdulahi title: Evaluation of a Phylogenetic Marker Based on Genomic Segment B of Infectious Bursal Disease Virus: Facilitating a Feasible Incorporation of this Segment to the Molecular Epidemiology Studies for this Viral Agent date: 2015-05-06 words: 6839 flesch: 42 summary: Phylogenetic analysis for both segments of IBDV genome was also performed, revealing the presence of a natural reassortant strain with segment A from vvIBDV strains and segment B from non-vvIBDV strains within Cuban IBDV population. Besides, the current work revealed the presence of a novel IBDV natural reassortant between segment A from vvIBDV strains and segment B from non-vvIBDV strains in Cuban IBDV population. keywords: analysis; bursal; disease; fig; genome; lineage; marker; segment b; segments; sequences; strains; virus; vvibdv cache: cord-001639-p9mbmfaq.txt plain text: cord-001639-p9mbmfaq.txt item: #148 of 672 id: cord-001707-piyo00yg author: Murray, Jillian title: Determining the Provincial and National Burden of Influenza-Associated Severe Acute Respiratory Illness in South Africa Using a Rapid Assessment Methodology date: 2015-07-08 words: 3880 flesch: 45 summary: Other countries that have influenza surveillance in place can also implement this methodology to estimate their national burden of severe influenza disease. Excess mortality due to pneumonia or influenza during influenza seasons among persons with acquired immunodeficiency syndrome Increased burden of respiratory viral associated severe lower respiratory tract infections in children infected with human immunodeficiency virus type-1 Severe influenza-associated respiratory infection in high HIV prevalence setting, South Africa Naturally-acquired influenza-specific CD4+ T-cell proliferative responses are impaired in HIV-infected African adults Influenza surveillance in 15 countries in Africa Lower respiratory tract infections associated with influenza A and B viruses in an area with a high prevalence of pediatric human immunodeficiency type 1 infection Seasonal influenza epidemiology in sub-Saharan Africa: a systematic review Twenty-five years of outpatient influenza surveillance in South Africa Recommendations pertaining to the use of viral vaccines: influenza 2013 Regional perspectives on influenza surveillance in Africa Strategy to enhance influenza surveillance worldwide World Health Organization. keywords: cases; hiv; influenza; province; sari; south cache: cord-001707-piyo00yg.txt plain text: cord-001707-piyo00yg.txt item: #149 of 672 id: cord-001716-lbtdex4p author: Gilca, Rodica title: Mid-Season Estimates of Influenza Vaccine Effectiveness against Influenza A(H3N2) Hospitalization in the Elderly in Quebec, Canada, January 2015 date: 2015-07-22 words: 4076 flesch: 32 summary: respiratory viral panel with in-house nucleic acid amplification tests for diagnosis of respiratory virus infections Methodologic issues regarding the use of three observational study designs to assess influenza vaccine effectiveness We thank the Quebec Ministry of Health (Ministère de la Santé et des Services sociaux du Québec) for providing financial support for this surveillance project. A number of other recent studies in Canada, the United States, and Europe have also reported interference from prior receipt of seasonal influenza vaccine [22] [23] keywords: 95%ci; a(h3n2; estimates; hospitalization; influenza; season; vaccine cache: cord-001716-lbtdex4p.txt plain text: cord-001716-lbtdex4p.txt item: #150 of 672 id: cord-001734-bbeznd3r author: Gupta, Garvita title: NMR and MD Studies Reveal That the Isolated Dengue NS3 Protease Is an Intrinsically Disordered Chymotrypsin Fold Which Absolutely Requests NS2B for Correct Folding and Functional Dynamics date: 2015-08-10 words: 9791 flesch: 46 summary: The NS2B (1-130) and NS3pro proteins were completely insoluble and all found in inclusion body, which were solubilized with PBS buffer (pH7.4) containing 8 M urea. 4 ppm, while all isolated NS3pro residues have the absolute values of (ΔCα-ΔCβ) < keywords: buffer; cofactor; complex; dengue; domain; dynamics; fig; hsqc; nmr; ns2b; ns3pro; protease; protein; residues; simulations; structures cache: cord-001734-bbeznd3r.txt plain text: cord-001734-bbeznd3r.txt item: #151 of 672 id: cord-001748-7e8px4vx author: Nobach, Daniel title: Shedding of Infectious Borna Disease Virus-1 in Living Bicolored White-Toothed Shrews date: 2015-08-27 words: 4889 flesch: 42 summary: For the investigation of long lasting virus shedding BoDV-1 infected animals were sampled again after at least more than 250 days in the husbandry. Whether naturally BoDV-1 infected shrews also display subtle deficits in learning, memory and/or social behavior, especially mating, needs to be addressed in further behavioral and breeding experiments. keywords: animals; bodv-1; borna; disease; infection; reservoir; shedding; shrews; time; transmission; virus cache: cord-001748-7e8px4vx.txt plain text: cord-001748-7e8px4vx.txt item: #152 of 672 id: cord-001761-yvd1n42f author: Yoshimura, Takeo title: Controlled Microwave Heating Accelerates Rolling Circle Amplification date: 2015-09-08 words: 4437 flesch: 43 summary: Moreover, RCA reactions containing a 4-fold excess concentration of the Bst-LF were accelerated by conventional as well as microwave heating. The objectives of the present research were to apply microwave heating to RCA and indicate factors that contribute to the microwave selective heating effect. keywords: buffer; dna; heating; microwave; rca; reaction; temperature cache: cord-001761-yvd1n42f.txt plain text: cord-001761-yvd1n42f.txt item: #153 of 672 id: cord-001781-afg1nmib author: Saksena, Sumeet title: Evidence for the Convergence Model: The Emergence of Highly Pathogenic Avian Influenza (H5N1) in Viet Nam date: 2015-09-23 words: 7628 flesch: 45 summary: Our study, the first to use CTI as a risk factor, found it had a large positive influence on HPAI H5N1 risk at the national level. von Thunen's Isolated State Health and peri-urban natural resource production Livestock production: recent trends, future prospects Anthropogenic factors and the risk of highly pathogenic avian influenza H5N1: prospects from a spatial-based model Prospects for emerging infections in East and southeast Asia 10 years after severe acute respiratory syndrome Zoonosis emergence linked to agricultural intensification and environmental change Risk factor modelling of the spatio-temporal patterns of highly pathogenic avian influenza (HPAIV) H5N1: a review Diversity and evenness: A unifying notation and its consequences Land mosaics: the ecology of landscapes and regions Characterization of Poultry Production Systems in Vietnam Spatio-temporal epidemiology of highly pathogenic avian influenza (subtype H5N1) in poultry in eastern India Agro-environmental determinants of avian influenza circulation: a multisite study in Thailand, Vietnam and Madagascar Risk factors for highly pathogenic avian influenza (HPAI) H5N1 infection in backyard chicken farms Risk analysis for the highly pathogenic avian influenza in Mainland China using meta-modeling Environmental factors contributing to the spread of H5N1 avian influenza in mainland China Flying over an infected landscape: distribution of highly pathogenic avian influenza H5N1 risk in South Asia and satellite tracking of wild waterfowl Environmental and anthropogenic risk factors for highly pathogenic avian influenza subtype H5N1 outbreaks in Romania Mapping spread and risk of avian influenza A (H7N9) in China Risk for infection with highly pathogenic avian influenza virus (H5N1) in backyard chickens Spatio-Temporal Occurrence Modeling of Highly Pathogenic Avian Influenza Subtype H5N1: A Case Study in the Red River Delta Rivers and flooded areas identified by medium-resolution remote sensing improve risk prediction of the highly pathogenic avian influenza H5N1 in Thailand Ecology and geography of avian influenza (HPAI H5N1) transmission in the Middle East and northeastern Africa Predictable ecology and geography of avian influenza (H5N1) transmission in Nigeria and West Africa Chagas disease risk in Texas The effect of habitat fragmentation and species diversity loss on hantavirus prevalence in Panama Soil-landscape modeling and spatial prediction of soil attributes Spatio-temporal dynamics of global H5N1 outbreaks match bird migration patterns Risk factors and characteristics of H5N1 Highly Pathogenic Avian Influenza (HPAI) post-vaccination outbreaks Very high resolution interpolated climate surfaces for global land areas A working guide to boosted regression trees Novel methods improve prediction of species' distributions from occurrence data An autologistic model for the spatial distribution of wildlife Multivariable geostatistics in S: the gstat package Ecological determinants of highly pathogenic avian influenza (H5N1) outbreaks in Bangladesh Species Distribution Models: Ecological Explanation and Prediction Across Space and Time Improving risk models for avian influenza: the role of intensive poultry farming and flooded land during the 2004 Thailand epidemic Modeling habitat suitability for occurrence of highly pathogenic avian influenza virus H5N1 in domestic poultry in Asia: a spatial multicriteria decision analysis approach Predicting the risk of avian influenza A H7N9 infection in live-poultry markets across Asia Principles and practical application of the receiver-operating characteristic analysis for diagnostic tests The effects of species' range sizes on the accuracy of distribution models: ecological phenomenon or statistical artefact? Seasonal Patterns in Human A (H5N1) Virus Infection: Analysis of Global Cases Integrated mapping of establishment risk for emerging vector-borne infections: a case study of canine leishmaniasis in southwest France Fragmentation analysis for prediction of suitable habitat for vectors: example of riverine tsetse flies in Burkina Faso The impact of habitat fragmentation on tsetse abundance on the plateau of eastern Zambia Spatial pattern analysis program for quantifying landscape structure Risk factors of highly pathogenic avian influenza H5N1 occurrence at the village and farm levels in the Red River Delta Region in Vietnam Factors in the emergence of infectious diseases We thank Nargis Sultana, University of Hawaii, Manoa for assistance with compiling a GIS database. keywords: avian; data; diversity; factors; h5n1; hpai; influenza; land; model; poultry; risk; studies; urban; use; wave cache: cord-001781-afg1nmib.txt plain text: cord-001781-afg1nmib.txt item: #154 of 672 id: cord-001843-ceatyj3o author: Huang, Yong title: Ultrasensitive Detection of RNA and DNA Viruses Simultaneously Using Duplex UNDP-PCR Assay date: 2015-11-06 words: 5196 flesch: 45 summary: The sensitivity, specificity, and reproducibility of the UNDP-PCR assay for TGEV TGEV genomic RNA was extracted using RNA Kit and reverse transcribed to synthesize cDNA. Therefore, a UNDP-PCR method for RNA virus TGEV needs to be established first. keywords: assay; dna; duplex; pcr; pcv2; rna; samples; tgev; undp; virus cache: cord-001843-ceatyj3o.txt plain text: cord-001843-ceatyj3o.txt item: #155 of 672 id: cord-001865-ji83zmy7 author: Kuroda, Kengo title: Immortalization of Fetal Bovine Colon Epithelial Cells by Expression of Human Cyclin D1, Mutant Cyclin Dependent Kinase 4, and Telomerase Reverse Transcriptase: An In Vitro Model for Bacterial Infection date: 2015-12-01 words: 5759 flesch: 43 summary: BFCE cells were seeded on the 8 well Millicell 1 EZ SLIDE (Millipore) at 5.0 ×10 4 cells. Fig 1B shows the PD value of BFCE primary cells (diamond) and BFCE-K4DT cells expressing CDK4R24C, cyclin D1, TERT (square). keywords: bacteria; bfce; bovine; cells; cyclin; enteritidis; epithelial; expression; fig; infection; k4dt; primary; tlr cache: cord-001865-ji83zmy7.txt plain text: cord-001865-ji83zmy7.txt item: #156 of 672 id: cord-001898-ntqyjqqk author: Huang, Chih-Wei title: Lys-315 at the Interfaces of Diagonal Subunits of δ-Crystallin Plays a Critical Role in the Reversibility of Folding and Subunit Assembly date: 2016-01-05 words: 6589 flesch: 43 summary: However, the urea dissociated monomers of K315A mutant protein in GdmCl were reversible folding through a multiple steps mechanism as measured by tryptophan and ANS fluorescence. As shown in Fig 2A, the dramatic changes in the signal for the first transition were due to subunit dissociation as reported previously, with the GdmCl concentrations for half transition ([D] 1/2 ) at 1 ± 0.05 and 0.5 ± 0.01 M for wildtype and K315A mutant protein, respectively [28] . keywords: conformation; crystallin; fig; gdmcl; k315a; monomeric; monomers; mutant; protein; type; urea cache: cord-001898-ntqyjqqk.txt plain text: cord-001898-ntqyjqqk.txt item: #157 of 672 id: cord-001909-yy9xp5ms author: Buß, O. title: Statistical Evaluation of HTS Assays for Enzymatic Hydrolysis of β-Keto Esters date: 2016-01-05 words: 7036 flesch: 46 summary: A variety of hydrolase screening assays is based on non-natural substrates with chromophoric groups. High throughput assays permit simultaneous measurement of samples in 96-to 1536-well plates so that 10 5 to 10 7 samples may be screended per day keywords: activity; assay; enzyme; esters; ethanol; evaluation; hts; hydrolases; indicator; keto; luminescence; reaction; screening; substrate cache: cord-001909-yy9xp5ms.txt plain text: cord-001909-yy9xp5ms.txt item: #158 of 672 id: cord-001910-6zfz2ns5 author: Zhang, Xianming title: Abdominal Muscle Activity during Mechanical Ventilation Increases Lung Injury in Severe Acute Respiratory Distress Syndrome date: 2016-01-08 words: 3991 flesch: 49 summary: The purpose of this study was to test the hypothesis that abdominal muscle activity during mechanically ventilation increases lung injury in severe ARDS. After lung injury, Beagles were randomly assigned into spontaneous breathing group (BIPAP(SB)) and abdominal muscle paralysis group (BIPAP(AP)). keywords: ards; bipap; group; injury; lung; muscle; pressure; ventilation cache: cord-001910-6zfz2ns5.txt plain text: cord-001910-6zfz2ns5.txt item: #159 of 672 id: cord-001958-2gt3fwpy author: Meseda, Clement A. title: Percutaneous Vaccination as an Effective Method of Delivery of MVA and MVA-Vectored Vaccines date: 2016-02-19 words: 8186 flesch: 35 summary: In the work described here, we demonstrate in mouse models that percutaneous inoculation of MVA elicited protective immune responses against lethal intranasal challenge with the Western Reserve (WR) strain of vaccinia virus, and at low doses of MVA, lower morbidity was recorded in mice that were vaccinated via the percutaneous route than in those immunized via the intramuscular or subcutaneous routes. Similar to studies investigating MVA as a smallpox vaccine, preclinical and clinical evaluation of MVA-vectored vaccines in development has relied predominantly on the use of intramuscular, intradermal or subcutaneous routes of MVA delivery. keywords: ankara; groups; influenza; mice; mva; pfu; responses; skin; smallpox; vaccination; vaccine; vaccinia; virus cache: cord-001958-2gt3fwpy.txt plain text: cord-001958-2gt3fwpy.txt item: #160 of 672 id: cord-001964-iy6qzq58 author: Muñoz-González, Sara title: Classical Swine Fever Virus vs. Classical Swine Fever Virus: The Superinfection Exclusion Phenomenon in Experimentally Infected Wild Boar date: 2016-02-26 words: 6947 flesch: 42 summary: Samples from animal 1 (Group A: Margarita acutely infected wild boar; 10 dpi), animal 5 (Group B: Cat01 persistently infected wild boar and superinfected with CSFV Margarita strain; 13 dpi), and a Pestivirus-free wild boar (animal 1 before infection), were used to assess SIE in PBMCs (Fig 1) . Furthermore, the samples analysed from superinfected animals (Group B: CSFV Catalonia 01 persistently infected inoculated with CSFV Margarita strain) only showed the sequence corresponding to the Cat01 strain [30] (Fig 4) . keywords: animals; cells; csfv; fever; group; ifn; infection; margarita; rna; samples; strain; swine; virus cache: cord-001964-iy6qzq58.txt plain text: cord-001964-iy6qzq58.txt item: #161 of 672 id: cord-001982-arczqdza author: Khajah, Maitham A. title: Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis date: 2016-03-10 words: 6231 flesch: 50 summary: This suggest that the antiinflammatory properties of Ang 1-7 are in part mediated through reduction of Ang II levels. Ang II expression determined by immunoblotting was increased at days 4 and 6 post-colitis induction compared to UT mice (Fig 2A) , as was ACE2. keywords: ang; angiotensin; colitis; colon; daily; dss; fig; i.p; mice; severity; treatment cache: cord-001982-arczqdza.txt plain text: cord-001982-arczqdza.txt item: #162 of 672 id: cord-001983-zo9yngfc author: Napp, S. title: Understanding Spatio-Temporal Variability in the Reproduction Ratio of the Bluetongue (BTV-1) Epidemic in Southern Spain (Andalusia) in 2007 Using Epidemic Trees date: 2016-03-10 words: 8782 flesch: 45 summary: BTV-1 epidemic in Andalusia resulted from a combination of local transmission and long distance jumps with the establishment of new foci that produced large variability in transmission, not only through time, but also among the different geographical areas. In these overlapping areas R t values are likely to be lower as the farms that get the infection are shared by different foci. keywords: andalusia; bluetongue; btv; btv-1; epidemic; farms; foci; r t; transmission; values cache: cord-001983-zo9yngfc.txt plain text: cord-001983-zo9yngfc.txt item: #163 of 672 id: cord-002023-7zd5zhbz author: Hiremath, Jagadish title: Entrapment of H1N1 Influenza Virus Derived Conserved Peptides in PLGA Nanoparticles Enhances T Cell Response and Vaccine Efficacy in Pigs date: 2016-04-19 words: 6517 flesch: 44 summary: In addition, results of ex vivo restimulation of LMNCs with all the four individual peptides elicited comparable peptide specific T cell response in NPP vaccinated pigs. Moreover, intramuscularly delivered flu vaccine induces poor mucosal IgA antibody and T cell responses [4] . keywords: antibody; cell; h1n1; influenza; m2e; npp; peptides; pigs; plga; response; specific; swiv; vaccine; virus cache: cord-002023-7zd5zhbz.txt plain text: cord-002023-7zd5zhbz.txt item: #164 of 672 id: cord-002043-z1b7pj3s author: Wang, Xue-Yang title: Comparative Transcriptome Analysis of Bombyx mori (Lepidoptera) Larval Midgut Response to BmNPV in Susceptible and Near-Isogenic Resistant Strains date: 2016-05-11 words: 5896 flesch: 36 summary: Down-regulation of transporter related genes, such as lactase-phlorizin hydrolase (LPH), B(0, +)-type amino acid transporter 1 (BAT1), actin cytoskeleton-regulatory complex protein PAN1 (PAN1), MFS-type transporter (MFS), and otoferlin, could repress virus infection in host cells [37] Apoptosis plays a vital role in regulating cell response in Lepidopteran insects during viral infections, where larvae use selective apoptosis and subsequent sloughing of the infected cells in the midgut epithelium to resist virus infection [51, 52] . keywords: analysis; apoptosis; bc9; bmnpv; bmnpv infection; bombyx; degs; expression; genes; infection; mori; p50; protein; resistance; silkworm; virus cache: cord-002043-z1b7pj3s.txt plain text: cord-002043-z1b7pj3s.txt item: #165 of 672 id: cord-002044-9xgt3tf4 author: Hendiger, Jacek title: Influence of the Pressure Difference and Door Swing on Heavy Contaminants Migration between Rooms date: 2016-05-12 words: 4537 flesch: 51 summary: During the measurement series with the door opened towards a negatively pressurized zone (Fig 10) , in the case of the lowest values of pressure difference (2.5 Pa), a considerable degree of contaminants migration to the Influence of the Pressure Difference and Door Swing on Heavy Contaminants Migration between Rooms room was observed. Unlike other studies which focus on the analysis of pressure difference, the present study looks at the contaminants which are heavier than air and on “pumping out” the contaminants by means of door swing. keywords: contaminants; difference; door; pressure; pressure difference; room; smoke cache: cord-002044-9xgt3tf4.txt plain text: cord-002044-9xgt3tf4.txt item: #166 of 672 id: cord-002094-7tewne3a author: Tago, Damian title: The Impact of Farmers’ Strategic Behavior on the Spread of Animal Infectious Diseases date: 2016-06-14 words: 6295 flesch: 47 summary: key: cord-002094-7tewne3a authors: Tago, Damian; Hammitt, James K.; Thomas, Alban; Raboisson, Didier title: The Impact of Farmers’ Strategic Behavior on the Spread of Animal Infectious Diseases date: 2016-06-14 journal: PLoS One DOI: 10.1371/journal.pone.0157450 sha: doc_id: 2094 cord_uid: 7tewne3a One of the main strategies to control the spread of infectious animal diseases is the implementation of movement restrictions. Movement restriction policies (MRPs) are one of the most popular strategies implemented within and between countries to fight the spread of infectious animal diseases in Europe and worldwide [1] . keywords: animals; disease; farmers; mrp; network; nodes; period; spread cache: cord-002094-7tewne3a.txt plain text: cord-002094-7tewne3a.txt item: #167 of 672 id: cord-002100-dt5zvebj author: He, Yonghua title: Transgenic Soybean Production of Bioactive Human Epidermal Growth Factor (EGF) date: 2016-06-17 words: 6802 flesch: 39 summary: Genistein enhances relaxation of the spontaneously hypertensive rat aorta by transactivation of epidermal growth factor receptor following binding to membrane estrogen receptors-α and activation of G protein-coupled, endothelial nitric acid synthase-dependent pathway Genistein increases epidermal growth factor receptor signaling and promotes tumor progression in advanced human prostate cancer The production of recombinant pharmaceutical proteins in plants Sowing the seeds of success: pharmaceutical proteins from plants Recombinant Pharmaceuticals from Plants: The Plant Endomembrane System as Bioreactor Commercialization of biopharmaceutical and bioindustrial proteins from plants Efficacy of a food plant-based oral cholera toxin β subunit vaccine Oral immunization with hepatitis β surface antigen expressed in transgenic plants Immunogenicity of recombinant LT-B delivered orally to humans in transgenic corn Expression of hepatitis B surface antigen (HBsAg) gene in transgenic banana (Musa Sp) Severe acute respiratory syndrome (SARS) S protein production in plants: development of recombinant vaccine Expression and immunogenicity of an Escherichia coli K99 fimbriae subunit antigen in soybean Protein expression systems: why soybean seeds? in Soybean-Molecular Aspects of Breeding Cosuppression of the α-subunits of β-conglycinin in transgenic soybean seeds induces the formation of endoplasmic reticulum-derived protein bodies Silencing of soybean seed storage proteins results in a rebalanced protein composition preserving seed protein content without major collateral changes in the metabolome and transcriptome Reduction of protease inhibitor activity by expression of a mutant Bowman-Birk gene in soybean seed Epidermal growth factor augments adaptation following small bowel resection: optimal dosage, route, and timing of administration Expression of functional recombinant human growth hormone in transgenic soybean seeds Processing and localization of bovine β-casein expressed in transgenic soybean seeds under control of a soybean lectin expression cassette Embryo-specific silencing of a transporter reduces phytic acid content of maize and soybean seeds Metabolically engineered oilseed crops with enhanced seed tocopherol An alternative to fish oils: metabolic engineering of oilseed crops to produce omega 3 long chain polyunsaturated fatty acids Correct targeting of proinsulin in protein storage vacuoles of transgenic soybean seeds High-level expression of basic fibroblast growth factor in transgenic soybean seeds and characterization of its biological activity Expression of correctly processed human growth hormone in seeds of transgenic tobacco plants Genistein analogues: effects on epidermal growth factor receptor tyrosine kinase and on stress-activated pathways Increased sulfur amino acids in soybean plants overexpressing the maize 15 kD zein protein Enhanced levels of methionine and cysteine in transgenic alfalfa (Medicago sativa L.) plants over-expressing the Arabidopsis cystathionine γ-synthase gene Transgenic soybean plants overexpressing O-acetylserine sulfhydrylase accumulate enhanced levels of cysteine and Bowman-Birk protease inhibitor in seeds Effects of proteome rebalancing and sulfur nutrition on the accumulation of methionine Dry seeds from two successive generations of PCR positive plants were analyzed by ELISA for the expression of EGF protein until all 7 lines were confirmed to be homozygous. keywords: cells; control; egf; egfr; expression; factor; growth; hegf; human; lines; milk; protein; seeds; soybean; soymilk; sulfur; transgenic cache: cord-002100-dt5zvebj.txt plain text: cord-002100-dt5zvebj.txt item: #168 of 672 id: cord-002141-9mxi4dzi author: Memczak, Henry title: Anti-Hemagglutinin Antibody Derived Lead Peptides for Inhibitors of Influenza Virus Binding date: 2016-07-14 words: 8796 flesch: 47 summary: The antibody derived peptide PeB and its mutant variant PeB GF are promising hemagglutinin binding peptides, which both could have potential for application in viral diagnostics and therapeutics. A more epitope-oriented accession to binding peptides is the search for paratope-derived peptides from variable regions of specific antibodies [24] . keywords: aichi; amino; antibody; binding; cells; energy; fig; h3n2; hemagglutinin; infection; influenza; inhibition; kcal; mol; peb; peptides; residues; virus cache: cord-002141-9mxi4dzi.txt plain text: cord-002141-9mxi4dzi.txt item: #169 of 672 id: cord-002180-gsdk5x3e author: Davies, Colin title: Expression of the NS5 (VPg) Protein of Murine Norovirus Induces a G1/S Phase Arrest date: 2016-08-24 words: 4504 flesch: 49 summary: In this study, we show that expression of viral NS5 protein in cell culture induces an accumulation of cells in the G 0 /G This study identified that NS5 (VPg), is capable of inducing cell cycle arrest in the absence of viral replication or other viral proteins in an analogous manner to MNV-1 infection. keywords: cell; cycle; expression; host; ns5; phase; protein; rna; viral cache: cord-002180-gsdk5x3e.txt plain text: cord-002180-gsdk5x3e.txt item: #170 of 672 id: cord-002222-rgqwm3vb author: Olarte-Castillo, Ximena A. title: Divergent Sapovirus Strains and Infection Prevalence in Wild Carnivores in the Serengeti Ecosystem: A Long-Term Study date: 2016-09-23 words: 7547 flesch: 39 summary: Information on sapovirus infection of wildlife is limited and is currently lacking for any free-ranging wildlife species in Africa. The likelihood of sapovirus infection decreased with increasing hyena group size, suggesting an encounter reduction effect, but was independent of socially mediated ano-genital contact, or the extent of the area over which an individual roamed. keywords: clan; days; hyenas; individuals; infection; likelihood; prevalence; range; samples; sapovirus; serengeti; size; species; strains; study; years cache: cord-002222-rgqwm3vb.txt plain text: cord-002222-rgqwm3vb.txt item: #171 of 672 id: cord-002305-qq73gr9y author: Anson, Marie title: Regulation and Maintenance of an Adoptive T-Cell Dependent Memory B Cell Pool date: 2016-11-23 words: 5437 flesch: 47 summary: It is possible that limited antigen-specific T-B cell encounters may constraint the number of responding B cells and thus determine linear precursor-progeny between naïve and memory B cells. Overall these findings suggest that the T-cell dependent memory B cell pool comprises distinct subsets of memory B cells with different properties and effector functions keywords: aid; antigen; cells; fig; hel; igm; memory; mice; specific; yfp cache: cord-002305-qq73gr9y.txt plain text: cord-002305-qq73gr9y.txt item: #172 of 672 id: cord-002398-0a3okta0 author: Myllykoski, Matti title: Structural aspects of nucleotide ligand binding by a bacterial 2H phosphoesterase date: 2017-01-31 words: 6162 flesch: 51 summary: In addition, a number of LigT complex structures with active-site ligands were solved, hence significantly extending the earlier results on the LigT structure, which was only available as a complex with the reaction product 2 0 -AMP In animals, 2-5As synthesized by 2 0 -5 0 -oligoadenylate synthases 2H enzyme active site structure have functions in innate immunity, whereby they specifically activate RNase L keywords: -amp; binding; cnpase; complex; enzyme; fig; ligand; ligt; phosphate; reaction; rna; site; structure; trna cache: cord-002398-0a3okta0.txt plain text: cord-002398-0a3okta0.txt item: #173 of 672 id: cord-002426-5e1xn7kj author: Falcón-Lezama, Jorge Abelardo title: Analysis of spatial mobility in subjects from a Dengue endemic urban locality in Morelos State, Mexico date: 2017-02-22 words: 5948 flesch: 43 summary: There was no significant difference between cases and population controls, regardless of age. b) Cases vs. population controls. keywords: area; cases; control; dengue; locality; mobility; population; study; time; transmission cache: cord-002426-5e1xn7kj.txt plain text: cord-002426-5e1xn7kj.txt item: #174 of 672 id: cord-002473-2kpxhzbe author: Das, Jayanta Kumar title: Chemical property based sequence characterization of PpcA and its homolog proteins PpcB-E: A mathematical approach date: 2017-03-31 words: 4616 flesch: 56 summary: Current protocols in molecular biology Phylogenetic analysis of protein sequences based on conditional LZ complexity Analyzing and synthesizing phylogenies using tree alignment graphs A probabilistic measure for alignment-free sequence comparison Simplification of protein sequence and alignment-free sequence analysis Phylogenies and the comparative method Progressive sequence alignment as a prerequisitetto correct phylogenetic trees Graph theory with applications to engineering and computer science Protein flexibility predictions using graph theory Dictionary of protein secondary structure: pattern recognition of hydrogenbonded and geometrical features Use of information discrepancy measure to compare protein secondary structures 2-D graphical representation of protein sequences and its application to coronavirus phylogeny A 2D graphical representation of protein sequence and its numerical characterization Similarity/dissimilarity analysis of protein sequences based on a new spectrum-like graphical representation Pse-in-One: a web server for generating various modes of pseudo components of DNA, RNA, and protein sequences Secondly, we build a graph theoretic model on using amino acid sequences which is also applied to the cytochrome c7 family members and some unique characteristics and their domains are highlighted. keywords: acids; amino; chemical; graph; group; ppca; ppcd; protein; sequence cache: cord-002473-2kpxhzbe.txt plain text: cord-002473-2kpxhzbe.txt item: #175 of 672 id: cord-002560-pue5q5wp author: Moreno, Paloma S. title: Characterisation of the canine faecal virome in healthy dogs and dogs with acute diarrhoea using shotgun metagenomics date: 2017-06-01 words: 5140 flesch: 47 summary: Our shotgun metagenomic sequence data indicated that the most frequent RNA viral family in dog samples with acute diarrhoea was Astroviridae, being identified in more than half of the diarrheal samples. Other dog sample had contigs/singletons similar to a canine kobuvirus (JN387133.1), covering 2.2% of complete genome. keywords: acute; astrovirus; canine; contigs; diarrhoea; dogs; faecal; genome; samples; sequences; singletons; viruses cache: cord-002560-pue5q5wp.txt plain text: cord-002560-pue5q5wp.txt item: #176 of 672 id: cord-002601-d8908t93 author: Arellano-Llamas, Rocío title: Molecular features of influenza A (H1N1)pdm09 prevalent in Mexico during winter seasons 2012-2014 date: 2017-07-10 words: 3380 flesch: 47 summary: Molecular and phylogenetic analyses of the whole viral genome are necessary to determine the antigenic and pathogenic characteristics of influenza viruses that cause severe outcomes of the disease. Mutations V344M and I354L of PB2 and N321K of PA, I397M, I435T of PB1, S498N of NP, N44S, V241L, N369K of NA V80I of M1, L90I of NS1 and S185T, S203T, E374K and S451N of HA appeared together during the evolution of influenza virus in Mexico. keywords: genome; group; influenza; mexico; pandemic; pb2; samples; sequences; substitutions; virus cache: cord-002601-d8908t93.txt plain text: cord-002601-d8908t93.txt item: #177 of 672 id: cord-002602-2qvyhjlp author: Roy, Amrita title: Solution conformations of Zika NS2B-NS3pro and its inhibition by natural products from edible plants date: 2017-07-10 words: 9013 flesch: 49 summary: On the other hand, our results suggest that despite being intrinsically disordered [44] , the C-half of Zika NS2B is absolutely required for implementing the catalytic actions, thus implying that the closed conformation might be enzymatically-active, which was also previously speculated [27] Unfortunately, NMR spectroscopy cannot be utilized to investigate the interaction between those compounds and Zika NS2B-NS3pro as the presence of 20% glycerol significantly increased the rotational tumbling time of the protein which made NMR peaks too broad for detection. keywords: activity; complex; complexes; dengue; fig; linked; nmr; ns2b; ns3pro; protease; virus; zika; zika ns2b; zikv cache: cord-002602-2qvyhjlp.txt plain text: cord-002602-2qvyhjlp.txt item: #178 of 672 id: cord-002621-sq5iod1w author: Attia, Mohamed I. title: New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres date: 2017-07-25 words: 5999 flesch: 42 summary: As an indicator of selectivity for tumor cells, compound 7e was analyzed for cell growth inhibitory activity in three non-tumorigenic cell lines. Twenty compounds, i.e. 4a-o and 7a-e, were analyzed for cancer cell growth inhibitory activity. keywords: activity; cancer; cell; compound; drug; fig; growth; microspheres; plga; release; value cache: cord-002621-sq5iod1w.txt plain text: cord-002621-sq5iod1w.txt item: #179 of 672 id: cord-002624-59nznqsd author: Ti, Jinfeng title: Identification of one B-cell epitope from NS1 protein of duck Tembusu virus with monoclonal antibodies date: 2017-07-26 words: 4074 flesch: 48 summary: In summary, one highly conserved B-cell epitope on TMUV NS1 protein were precisely screened and identified which could provide an important basis and data for understanding the antigenic structure of NS1 protein and the clinical application of epitope-mediated detecting and diagnostic methods. In this study, one B-cell epitope was screened by prokaryotic expression system to express a series of small peptides of One B-cell epitope from TMUV NS1 protein truncated protein and analyzed by Western Blotting. keywords: cell; epitope; mab; ns1; protein; times; tmuv; virus; washing cache: cord-002624-59nznqsd.txt plain text: cord-002624-59nznqsd.txt item: #180 of 672 id: cord-002705-ntokyoai author: Nasir, Nazrila Hairin title: Effectiveness of a fluid chart in outpatient management of suspected dengue fever: A pilot study date: 2017-10-04 words: 4467 flesch: 53 summary: Dengue: guidelines for diagnosis, treatment, prevention and control Dengue and dengue haemorrhagic fever Fact sheet No. 117 Cost of Dengue Cases in Eight Countries in the Americas and Asia: A Prospective Study Quality of life of dengue patients Fluid intake and decreased risk for hospitalization for dengue fever Comparison of the effects of oral hydration and intravenous fluid replacement in adult patients with non-shock dengue hemorrhagic fever in Taiwan Randomised primary health center based interventions to improve the diagnosis and treatment of undifferentiated fever and dengue in Vietnam Clinical and laboratory features that distinguish dengue from other febrile illnesses in endemic populations Use of simple laboratory features to distinguish the early stage of severe acute respiratory syndrome from dengue fever Early clinical and laboratory indicators of acute dengue illness Evaluating the effectiveness of a fluid chart to improve oral intake in suspected dengue fever patients: a feasibility study Early predictors of dengue infection in adults (EPOD)-A Malaysian outpatient experience Protocol for out-patient management of dengue illness in young adults Dengue Guidelines for Diagnosis, Treatment, Prevention and Control New Edition. The fluid chart is a simple, inexpensive tool that may reduce hospitalization and intravenous fluid requirement in suspected dengue patients. keywords: care; dengue; fluid; group; intervention; patients; study cache: cord-002705-ntokyoai.txt plain text: cord-002705-ntokyoai.txt item: #181 of 672 id: cord-002811-5hrydciz author: Hercik, Christine title: A diagnostic and epidemiologic investigation of acute febrile illness (AFI) in Kilombero, Tanzania date: 2017-12-29 words: 6513 flesch: 37 summary: This study is the first to employ two syndromic TaqMan Array Cards for the simultaneous survey of 57 different organisms to better characterize the type and prevalence of detected agents among febrile patients. In order to inform clinical management and optimize treatment regimens for febrile patients, information on common causes and associations of febrile illness, particularly in areas endemic to malaria, is critically required. keywords: afi; agents; blood; children; detection; fever; illness; malaria; mean; patients; study; tac; tanzania; values cache: cord-002811-5hrydciz.txt plain text: cord-002811-5hrydciz.txt item: #182 of 672 id: cord-002834-2htnywef author: Tsuchiaka, Shinobu title: Genetic diversity and recombination of enterovirus G strains in Japanese pigs: High prevalence of strains carrying a papain-like cysteine protease sequence in the enterovirus G population date: 2018-01-11 words: 3006 flesch: 41 summary: key: cord-002834-2htnywef authors: Tsuchiaka, Shinobu; Naoi, Yuki; Imai, Ryo; Masuda, Tsuneyuki; Ito, Mika; Akagami, Masataka; Ouchi, Yoshinao; Ishii, Kazuo; Sakaguchi, Shoichi; Omatsu, Tsutomu; Katayama, Yukie; Oba, Mami; Shirai, Junsuke; Satani, Yuki; Takashima, Yasuhiro; Taniguchi, Yuji; Takasu, Masaki; Madarame, Hiroo; Sunaga, Fujiko; Aoki, Hiroshi; Makino, Shinji; Mizutani, Tetsuya; Nagai, Makoto title: Genetic diversity and recombination of enterovirus G strains in Japanese pigs: High prevalence of strains carrying a papain-like cysteine protease sequence in the enterovirus G population date: 2018-01-11 journal: PLoS One DOI: 10.1371/journal.pone.0190819 sha: doc_id: 2834 cord_uid: 2htnywef To study the genetic diversity of enterovirus G (EV-G) among Japanese pigs, metagenomics sequencing was performed on fecal samples from pigs with or without diarrhea, collected between 2014 and 2016. The G2-PL-CP strain HgYa2-1 showed high homology Genetic diversity and recombination of enterovirus G strains in Japanese pigs to G2 strains in the tree for VP4-VP3 and VP1, whereas HgYa2-1 showed high similarity with G1-PL-CP lineage 1 strains in regions P2 and P3 (Fig 3A) . keywords: ishi; recombination; sequence; strains cache: cord-002834-2htnywef.txt plain text: cord-002834-2htnywef.txt item: #183 of 672 id: cord-002848-w6q1x1zs author: Zhang, Ailian title: Immunostimulatory activity of water-extractable polysaccharides from Cistanche deserticola as a plant adjuvant in vitro and in vivo date: 2018-01-23 words: 5472 flesch: 48 summary: Detection of WPCD immunomodulatory activity in vivo. Thus, WPCD adjuvant activity data in DCs in vitro may provide valuable information for animal models. keywords: activity; adjuvants; cells; dcs; igg; mice; ova; polysaccharides; wpcd cache: cord-002848-w6q1x1zs.txt plain text: cord-002848-w6q1x1zs.txt item: #184 of 672 id: cord-002889-fie121ns author: White, Michael title: Development of improved therapeutic mesothelin-based vaccines for pancreatic cancer date: 2018-02-23 words: 4884 flesch: 41 summary: In addition, the MVA virus has oncolytic properties in vitro as it can replicate in and kill Panc02 pancreatic adenocarcinoma cell line tumor cells, even though it is unable to replicate in most mammalian cells. For pre-vaccination of mice, mice were injected i.m. with 3.8 x 10 7 pfu/mouse, and then boosted with 1.5 x 10 7 pfu/mouse, and challenged with Panc02 tumor cells as above. keywords: anti; cancer; cells; mesothelin; mice; mouse; mva; panc02; response; tumor; virus; viruses cache: cord-002889-fie121ns.txt plain text: cord-002889-fie121ns.txt item: #185 of 672 id: cord-002890-g7aje88u author: Wood, Paul L. title: Lipidomic analysis of immune activation in equine leptospirosis and Leptospira-vaccinated horses date: 2018-02-23 words: 3281 flesch: 32 summary: According to HIV Stage of Infection, Pace of Disease Progression, Viremia Level and Immunological Response to Treatment Preliminary evaluation of a dual antigen ELISA to distinguish vaccinated from Leptospira infected horses Clinical, serological and echocardiographic examination of healthy field dogs before and after vaccination with a commercial tetravalent leptospirosis vaccine Levels of cyclic phosphatidic acid are increased in surfactant from asthmatic horses exposed to hay Secretory phospholipase A2 in the pathogenesis of acute dengue infection Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection Targeting phospholipase D in cancer, infection and neurodegenerative disorders Phospholipase D promotes Arcanobacterium haemolyticum adhesion via lipid raft remodeling and host cell death following bacterial invasion Cyclic phosphatidic acid-a unique bioactive phospholipid PPAR γ Networks in Cell Signaling: Other lipids of interest were triacylglycerols that were only elevated in the serum of infected horses and sphingomyelins that were increased only in the serum of vaccinated horses. keywords: activation; horses; immune; infection; leptospira; leptospirosis; lipid; serum; tag; vaccinated cache: cord-002890-g7aje88u.txt plain text: cord-002890-g7aje88u.txt item: #186 of 672 id: cord-002901-u4ybz8ds author: Yu, Chanki title: Acral melanoma detection using a convolutional neural network for dermoscopy images date: 2018-03-07 words: 3517 flesch: 47 summary: Dermoscopy images of BN were divided into nine types, and AM images into three types according to the reference [15] , by two dermatologists. Although further data analysis is necessary to improve their accuracy, convolutional neural networks would be helpful to detect acral melanoma from dermoscopy images of the hands and feet. keywords: cnn; dermoscopy; expert; images; melanoma; non; training cache: cord-002901-u4ybz8ds.txt plain text: cord-002901-u4ybz8ds.txt item: #187 of 672 id: cord-002913-k5b6abyk author: Kim, Ha Kyun title: Asymmetric expression level of clock genes in left vs. right nasal mucosa in humans with and without allergies and in rats: Circadian characteristics and possible contribution to nasal cycle date: 2018-03-13 words: 4947 flesch: 42 summary: The domestic pig as an experimental animal for studies on the nasal cycle Observations on the reaction of the normal nasal mucous membrane Some practical considerations of the physiology of the upper respiratory tract Observations on the alternate erectility of the nasal mucous membrane The central reciprocal control of nasal vasomotor oscillations Sympathetic control of nasal erectile tissue The influence of the hypothalamus on the sympathetic innervation of the nasal vasculature of the cat Day-night differences in mucosal plasma proteins in common cold Circadian changes in the secretory activity of nasal mucosa Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research Guidelines for reporting experiments involving animals: the ARRIVE guidelines Circadian rhythm of clock genes in human adipose explants Melatonin signaling modulates clock genes expression in the mouse retina Clock genes display rhythmic expression in human hearts Circadian clocks in rat skin and dermal fibroblasts: differential effects of aging, temperature and melatonin Expression of the circadian clock genes clock and period1 in human skin Molecular clock is involved in predictive circadian adjustment of renal function Glucocorticoids reset the nasal circadian clock in mice Scanning electron microscopy of arteriovenous anastomosis in nasal respiratory mucosa Autonomic innervation of the nasal mucosa Nasal resistance and nasal blood flow in postural changes Sympathetic influence on the nasal mucosa Autonomic regulation of nasal vessels during changes in body position Effects of posture change on nasal patency Time is of the essence: vascular complicaqtion of the circadian clock Circadian clocks and vascular function Vascular disease in mice with a dysfunctional circadian clock Schroder Elizabeth A. Smooth-muscle BMAL1 particiaptes in blood pressure circadian rhythm regulation Effect of circadian rhythm on clinical and pathophysiological conditions and inflammation The genetics of mammalian circadian order and disorder: implications for physiology and disease Disruption of SIRT1-mediated control of circadian molecular clock and inflammation in chronic obstructive pulmonary disease Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of Altered circadian clock gene expression in patients with schizophrenia Circadian timekeeping is disturbed in rheumatoid arthritis at molecular level Optimization of dosing schedule of daily inhalant dexamethasone to minimize phase shifting of clock gene expression rhythm in the lungs of the ashma mouse model Circadian clock gene Period2 regulates a time-of -day-dependent variation in cutaneous anaphylactic reaction Disruption of the suprachiasmatic neucleus blunts a time of day-dependent variation in systemic anaphylactic reaction in mice Biological clock dysfuntion exacerbates contact hypersensitivity in mice Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis Immunohistochemical localization of subtypes of muscarinic receptors in human inferior turbinate mucosa M1 and M3 muscarinic antagonists inhibit human nasal glandular secretion in vitro Vagal regulation of respiratory Clocks in mice This work was supported by The Basic Science Research Program through the National Research Foundation of Korea (2016R1D1A1A02936927). In this respect, although the relationships between allergic rhinitis and clock genes functions remains unclear, we hypothesized that clock genes expression levels might be altered in allergic nasal mucosa in comparison with their levels in normal nasal mucosa. keywords: circadian; clock; expression; genes; human; levels; mucosa; nasal; per2; rat cache: cord-002913-k5b6abyk.txt plain text: cord-002913-k5b6abyk.txt item: #188 of 672 id: cord-002935-jq1xumrh author: Postnikova, Elena title: Testing therapeutics in cell-based assays: Factors that influence the apparent potency of drugs date: 2018-03-22 words: 6245 flesch: 51 summary: In contrast, EBOV spread on Vero E6 cells varied considerably between cell passages 6-28 with peak infection (replication efficacy) at cell culture passages 12-14 ( Fig 3A) and equally lower for early or late passages. The EBOV/Mak titer was determined by plaque assay in Vero E6 cells. keywords: activity; assay; cells; drug; ebola; ebov; hpi; huh; moi; time; toremifene; vero; virus cache: cord-002935-jq1xumrh.txt plain text: cord-002935-jq1xumrh.txt item: #189 of 672 id: cord-002939-6a3ga6v9 author: Ribeiro, Ana Freitas title: Severe influenza A(H1N1)pdm09 in pregnant women and neonatal outcomes, State of Sao Paulo, Brazil, 2009 date: 2018-03-26 words: 4663 flesch: 41 summary: key: cord-002939-6a3ga6v9 authors: Ribeiro, Ana Freitas; Pellini, Alessandra Cristina Guedes; Kitagawa, Beatriz Yuko; Marques, Daniel; Madalosso, Geraldine; Fred, Joao; Albernaz, Ricardo Kerti Mangabeira; Carvalhanas, Telma Regina Marques Pinto; Zanetta, Dirce Maria Trevisan title: Severe influenza A(H1N1)pdm09 in pregnant women and neonatal outcomes, State of Sao Paulo, Brazil, 2009 date: 2018-03-26 journal: PLoS One DOI: 10.1371/journal.pone.0194392 sha: doc_id: 2939 cord_uid: 6a3ga6v9 To investigate the factors associated with death and describe the gestational outcomes in pregnant women with influenza A(H1N1)pdm09, we conducted a case-control study (deaths and recovered) in hospitalized pregnant women with laboratory-confirmed influenza A(H1N1)pdm09 with severe acute respiratory illness (SARI) in the state of São Paulo from June 9 to December 1, 2009. Antiviral treatment was a protective Severe influenza A(H1N1) in pregnant women factor for death when administered within the first 48 hours after the onset of symptoms, OR 0.16 (95% CI 0.05-0.50), and when administered 48 to 72 hours after the onset of symptoms, OR 0.09 (95% CI 0.01-0.87). keywords: cases; controls; death; health; hospitalization; influenza; pandemic; risk; women cache: cord-002939-6a3ga6v9.txt plain text: cord-002939-6a3ga6v9.txt item: #190 of 672 id: cord-002953-4rqoenhr author: Arruda, Andréia Gonçalves title: Time-series analysis for porcine reproductive and respiratory syndrome in the United States date: 2018-04-03 words: 3164 flesch: 35 summary: Data was aggregated retrospectively at the week level for the number of herds containing animals actively shedding PRRS virus. First, we characterized the number of sites per region, the mean (standard deviation [SD]) number of animals in the herds and the mean number of farms containing animals actively shedding PRRS virus (considering a closed population) over time. keywords: porcine; prrs; states; swine; syndrome; time; virus cache: cord-002953-4rqoenhr.txt plain text: cord-002953-4rqoenhr.txt item: #191 of 672 id: cord-002957-gw2cow0d author: Gray, Darren W. title: DIVA metabolomics: Differentiating vaccination status following viral challenge using metabolomic profiles date: 2018-04-05 words: 7446 flesch: 30 summary: Elevated levels of biliverdin and bilirubin and decreased 3-indolepropionic acid in non-vaccinated animals at day 6 p.i. may be associated with increased oxidative stress and reactive oxygen scavenging at periods of peak virus titre. During latter stages of infection, increased levels of N-[(3α,5β,12α)-3,12-dihydroxy-7,24-dioxocholan-24-yl]glycine and lysophosphatidycholine and decreased enterolactone in non-vaccinated animals may reflect suppression of innate immune response mechanisms and progression to adaptive immune responses. keywords: acid; analysis; animals; bovine; bpi3v; calves; challenge; data; day; disease; infection; metabolite; p.i; plasma; post; study; vaccinated; vaccination; virus cache: cord-002957-gw2cow0d.txt plain text: cord-002957-gw2cow0d.txt item: #192 of 672 id: cord-002973-bkr4ndl2 author: Seifi, Morteza title: Accurate prediction of functional, structural, and stability changes in PITX2 mutations using in silico bioinformatics algorithms date: 2018-04-17 words: 5066 flesch: 35 summary: We used two parallel prediction methods to investigate the possible effects on PITX2 protein structure and stability of missense variants. To assess the performance of eight different stability predictor programs (DUET, SDM, mCSM, I-Mutant3.0, MUpro, iPTREE-STAB, CUPSAT, and iStable) in predicting the effect of missense mutations on PITX2 protein stability, the change in protein stability (ΔΔG) were computed for all 24 PITX2 homeodomain variants (15 functionally characterised and 9 functionally uncharacterised mutations) (Table 7) . keywords: amino; missense; modeling; mutations; pitx2; programs; protein; stability; structure; variants cache: cord-002973-bkr4ndl2.txt plain text: cord-002973-bkr4ndl2.txt item: #193 of 672 id: cord-003024-17f1evh3 author: Nunes, Márcio Roberto Teixeira title: Revalidation and genetic characterization of new members of Group C (Orthobunyavirus genus, Peribunyaviridae family) isolated in the Americas date: 2018-05-24 words: 3450 flesch: 43 summary: So far, previous studies have described the genomic characteristics S and M RNA segments of members of Group C viruses, but many sequences generated by Sanger sequencing approach were divergent, despite using the same strains of group C viruses Thus, our study reported the genomes of three new members in Group C virus (Apeu strain BeAn848, Itaqui strain BeAn12797 and Nepuyo strain BeAn10709), as well as re-sequencing of original strains of five members: Caraparu (strain BeAn3994), Madrid (strain BT4075), Murucutu (strain BeAn974), Oriboca (strain BeAn17), and Marituba (strain BeAn15). keywords: fig; group; members; orthobunyavirus; protein; segments; sequences; strain; viruses cache: cord-003024-17f1evh3.txt plain text: cord-003024-17f1evh3.txt item: #194 of 672 id: cord-003062-qm8kalyt author: Chowdhury, Fazle Rabbi title: The association between temperature, rainfall and humidity with common climate-sensitive infectious diseases in Bangladesh date: 2018-06-21 words: 4998 flesch: 48 summary: A previous study in Chittagong, Bangladesh showed increased malaria cases with increasing temperature Table 4 . Unfortunately, very few studies on the relationship between various environmental variables and trends of infectious disease incidence have been performed so far in Bangladesh, although there are reports of some infections increasing sporadically in different regions of the country keywords: bangladesh; cases; change; climate; diseases; encephalitis; malaria; pneumonia; study; temperature cache: cord-003062-qm8kalyt.txt plain text: cord-003062-qm8kalyt.txt item: #195 of 672 id: cord-003125-iptisi1m author: Machablishvili, Ann title: Overview of three influenza seasons in Georgia, 2014–2017 date: 2018-07-27 words: 3725 flesch: 39 summary: We aimed to present Influenza Like Illness (ILI) and Severe Acute Respiratory Infection (SARI) surveillance data and characterize influenza viruses circulating in the country over three influenza seasons. RESULTS: 32% (397/1248) of ILI and 29% (581/1997) of SARI patients tested were positive for influenza viruses. keywords: georgia; ili; influenza; sari; seasons; surveillance; viruses; years cache: cord-003125-iptisi1m.txt plain text: cord-003125-iptisi1m.txt item: #196 of 672 id: cord-003244-abs3tc3r author: Chong, Ka Chun title: Monitoring the age-specificity of measles transmissions during 2009-2016 in Southern China date: 2018-10-08 words: 4847 flesch: 48 summary: During 2000-2009, the number of measles cases showed a remarkable decrease but remained around 6.8 per 100,000 on average [2] . Daily notifications of measles cases from January 1, 2009 to December 31, 2016 were collected from the National Infectious Disease Monitoring Information System (NIDMIS), as complied by the Center for Disease Control and Prevention (CDC) of Guangdong Province. keywords: age; cases; children; china; groups; measles; months; vaccination; years cache: cord-003244-abs3tc3r.txt plain text: cord-003244-abs3tc3r.txt item: #197 of 672 id: cord-003270-vu9b5a14 author: Panahi, Heidar Ali title: A comprehensive in silico analysis for identification of therapeutic epitopes in HPV16, 18, 31 and 45 oncoproteins date: 2018-10-24 words: 7034 flesch: 46 summary: Regarding the fundamental importance of epitope prediction in vaccine development, we investigated the best potential CD8+ T cell epitopes from the E5, E6, and E7 oncoproteins of four prevalent hrHPV genotypes (16, 18, 31 and 45) in the world and Iran There are several limitations for epitope prediction: 1) The major drawback of peptidebased vaccines is low immunogenicity [92, 93] . keywords: binding; cell; epitopes; hla; hpv; human; mhc; molecules; papillomavirus; peptide; prediction; step cache: cord-003270-vu9b5a14.txt plain text: cord-003270-vu9b5a14.txt item: #198 of 672 id: cord-003377-9vkhptas author: Wu, Tong title: The live poultry trade and the spread of highly pathogenic avian influenza: Regional differences between Europe, West Africa, and Southeast Asia date: 2018-12-19 words: 4969 flesch: 43 summary: The response variable in all models estimated was a log transformation of the number of H5N1 poultry outbreaks in a given country in a given year, obtained from the Emergency Prevention System for Animal Health (EMPRES), a joint project of the FAO and OIE The distribution of H5N1 poultry outbreaks between 2004-2016 across the member states of ASEAN, ECOWAS, and EU. keywords: avian; biosecurity; bloc; ecowas; h5n1; influenza; model; poultry; risk; trade cache: cord-003377-9vkhptas.txt plain text: cord-003377-9vkhptas.txt item: #199 of 672 id: cord-003404-eqgc8v7y author: May, Win Lai title: Impact of glucose-6-phosphate dehydrogenase deficiency on dengue infection in Myanmar children date: 2019-01-02 words: 4952 flesch: 52 summary: The clinical parameters of warning signs were more frequent in severe dengue patients, which was in agreement with previous studies; hepatomegaly was a risk factor of DSS or severe dengue infection In cases of severe G6PD deficiency, the lack of oxidative metabolism can cause a reduction in oxygen-dependent phagocytosis as observed in chronic granulomatous disease [4] and allows for viral replication keywords: activity; children; deficiency; dehydrogenase; dengue; g6pd; infection; myanmar; patients; phosphate; study cache: cord-003404-eqgc8v7y.txt plain text: cord-003404-eqgc8v7y.txt item: #200 of 672 id: cord-003484-ylpa702c author: Blázquez, Elena title: Evaluation of the effectiveness of the SurePure Turbulator ultraviolet-C irradiation equipment on inactivation of different enveloped and non-enveloped viruses inoculated in commercially collected liquid animal plasma date: 2019-02-21 words: 7006 flesch: 47 summary: The objective of this study was to assess inactivation efficiency of the SurePure Turbulator UV-C irradiation system with selected swine enveloped viruses Pseudorabies virus (PRV), Because antibodies against porcine viruses are not expected to be found in bovine blood, bovine plasma was inoculated with PRV, PRRSV, PEDV, CSFV, SIV, SVA, SVDV, PPV and PCV-2. keywords: bovine; cells; inactivation; irradiation; non; plasma; porcine; tcid; titer; virus; viruses cache: cord-003484-ylpa702c.txt plain text: cord-003484-ylpa702c.txt item: #201 of 672 id: cord-003498-4ct0ywnw author: Bdeir, Najat title: A system for production of defective interfering particles in the absence of infectious influenza A virus date: 2019-03-01 words: 6225 flesch: 42 summary: Thus, more red fluorescent cells were observed when supernatants from PB2 expressing cells were added to MDCK-PB2opt as compared to MDCK-PB2 cells (Fig 5B) . This matches data published for DI-244 generated by use of standard virus [35] and demonstrates that DIPs produced in PB2 expressing cells are fully functional, although the activity of purified DIPs remains to be examined. keywords: cells; di-244; dips; fig; iav; influenza; mdck; pb2; pb2opt; production; supernatants; virus cache: cord-003498-4ct0ywnw.txt plain text: cord-003498-4ct0ywnw.txt item: #202 of 672 id: cord-003503-t6cnjwpd author: Sung, Ming-Hua title: Phylogeographic investigation of 2014 porcine epidemic diarrhea virus (PEDV) transmission in Taiwan date: 2019-03-06 words: 3363 flesch: 41 summary: PloS one Heterogeneity in spike protein genes of porcine epidemic diarrhea viruses isolated in Korea Detection and molecular diversity of spike gene of porcine epidemic diarrhea virus in China The S2 glycoprotein subunit of porcine epidemic diarrhea virus contains immunodominant neutralizing epitopes Cellular entry of the porcine epidemic diarrhea virus Sequence analysis of the partial spike glycoprotein gene of porcine epidemic diarrhea viruses isolated in Korea Coronaviruses: structure and genome expression Role of transportation in spread of porcine epidemic diarrhea virus infection, United States. keywords: data; diarrhea; epidemic; pedv; pig; porcine; strains; taiwan; transmission; virus cache: cord-003503-t6cnjwpd.txt plain text: cord-003503-t6cnjwpd.txt item: #203 of 672 id: cord-003507-22ylifqo author: Kelly, J. Daniel title: Projections of Ebola outbreak size and duration with and without vaccine use in Équateur, Democratic Republic of Congo, as of May 27, 2018 date: 2019-03-07 words: 4483 flesch: 44 summary: List of 21 prior Ebola outbreaks from 1976 to 2016 by time period, country, confirmed/probable reported and time series case count, outbreak inclusion into the regression and stochastic models. We modeled Ebola virus transmission using a stochastic branching process model that included reproduction numbers from past Ebola outbreaks and a particle filtering method to generate a probabilistic projection of the outbreak size and duration conditioned on its reported trajectory to date; modeled using high (62%), low (44%), and zero (0%) estimates of vaccination coverage (after deployment). keywords: cases; disease; ebola; evd; model; outbreak; size; vaccination; virus cache: cord-003507-22ylifqo.txt plain text: cord-003507-22ylifqo.txt item: #204 of 672 id: cord-003548-zuwt7gk5 author: Cai, Haiming title: Modulating the 3’ end-DNA and the fermentation process for enhanced production and biological activity of porcine interferon-gamma date: 2019-03-26 words: 6855 flesch: 41 summary: The researchers also used different expression systems to express pIFN-γ, but most of them have a problem with low protein expression or activity, which limits the further application of pIFN-γ Protein expression of pIFN-γ in P. pastoris. keywords: -his; -his tag; cells; expression; fermentation; gene; pastoris; pichia; pifn; protein; tag; γ protein cache: cord-003548-zuwt7gk5.txt plain text: cord-003548-zuwt7gk5.txt item: #205 of 672 id: cord-003551-jzfl4xuk author: Ciejka, Justyna title: Synthetic sulfonated derivatives of poly(allylamine hydrochloride) as inhibitors of human metapneumovirus date: 2019-03-28 words: 3075 flesch: 46 summary: At 1000 μg/ml no inhibition of early steps of virus infection was noted for carrageenans or NSPAHs (first four functional assays, S4-S7 Figs), but we observed strong inhibition of progeny virus production in assay 5, wherein the inhibitors were added 2 h after the inoculation. Cells were propagated in T75 flasks (TPP, Switzerland) at 37˚C in atmosphere containing 5% CO 2 . hMPV virus stock (clinical isolate, clade B2) was kindly provided by Dr. Oliver Schildgen (Institute of Pathology, Witten/Herdecke University). keywords: carrageenan; cells; hmpv; human; infection; metapneumovirus; polymers; virus cache: cord-003551-jzfl4xuk.txt plain text: cord-003551-jzfl4xuk.txt item: #206 of 672 id: cord-003602-wtestt8i author: Jung, Eunok title: Strategies in regulating glioblastoma signaling pathways and anti-invasion therapy date: 2019-04-22 words: 8919 flesch: 44 summary: A mathematical model of glioblastoma tumor spheroid invasion in a three-dimensional in vitro experiment Targeting adaptive glioblastoma: an overview of proliferation and invasion Crosstalk between glial and glioblastoma cells triggers the go-or-grow phenotype of tumor cells Dynamics and pattern formation in invasive tumor growth Proliferation and invasion: plasticity in tumor cells Reciprocal activation of transcription factors underlies the dichotomy between proliferation and invasion of glioma cells Evolutionary game theory in an agent-based brain tumor model: exploring the Genotype-Phenotype link Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits The role of the tumor microenvironment in glioblastoma: A mathematical model AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment Showering c-MET-dependent cancers with drugs Aberrant constitutive activation of nuclear factor kap-paB in glioblastoma multiforme drivesinvasive phenotype Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state Detection of circulating tumour cell clusters in human glioblastoma Extraneural Glioblastoma Multiforme Vertebral Metastasis Complex role of NK cells in regulation of oncolytic virus-bortezomib therapy A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment Glioma progression through the prism of heat shock protein mediated extracellular matrix remodeling and epithelial to mesenchymal transition Qualitative network modeling of the MYC-p53 control system of cell proliferation and differentiation Chondroitin sulfate proteoglycans from salmon nasal cartilage inhibit angiogenesis The mode and dynamics of glioblastoma cell invasion into a decellularized tissue-derived extracellular matrix-based three-dimensional tumor model Extracellular matrix remodeling in vivo for enhancing tumor-targeting efficiency of nanoparticle drug carriers using the pulsed high intensity focused ultrasound Engineering strategies to mimic the glioblastoma microenvironment Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins Enhancing the therapeutic efficacy of adenovirus in combination with biomaterials Targeted therapies in bladder cancer-an update Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor Retargeting polymer-coated adenovirus to the FGF receptor allows productive infection and mediates efficacy in a peritoneal model of human ovarian cancer TGF-beta signaling and its targeting for glioma treatment Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling. Despite advances in these approaches, glioma cells can still invade the neighboring tissues beyond detection leading to tumor recurrence. keywords: ampk; cell; control; cycle; drug; ffi; ffi ffi; fig; glioblastoma; glioma; glucose; infusion; invasion; mir-451; mtor; proliferation; signaling; tumor cache: cord-003602-wtestt8i.txt plain text: cord-003602-wtestt8i.txt item: #207 of 672 id: cord-003712-mafz21no author: Perez Vidakovics, Maria Laura A. title: Junín virus induces autophagy in human A549 cells date: 2019-06-19 words: 6207 flesch: 41 summary: in JUNV infected cells compared to the mock, indicating the activation of autophagy during JUNV infection of A549 cells. The localization of viral proteins in infected cells was analysed using a specific Given that autophagy is increased during JUNV infection, we then determined whether cellular autophagy regulates JUNV multiplication. keywords: autophagosomes; autophagy; cells; fig; infected; infection; junv; lc3; membrane; protein; replication; virus cache: cord-003712-mafz21no.txt plain text: cord-003712-mafz21no.txt item: #208 of 672 id: cord-003841-7uaj9hmx author: Desmonts de Lamache, D. title: Immuno-modulating properties of Tulathromycin in porcine monocyte-derived macrophages infected with porcine reproductive and respiratory syndrome virus date: 2019-08-23 words: 8002 flesch: 34 summary: Treatment with tulathromycin (1mg/mL) significantly reduced PRRSV cell necrosis at 12 hours (Fig 9) . However, due to its high antigenic variability and poorly understood immunopathogenesis, there is currently no effective vaccine or treatment to control PRRSV infection. keywords: anti; cells; effects; fig; infection; l929; macrophages; mdms; monocyte; porcine; production; prrsv; syndrome; tulathromycin; usa; virus cache: cord-003841-7uaj9hmx.txt plain text: cord-003841-7uaj9hmx.txt item: #209 of 672 id: cord-004017-gcmpatlb author: Errecaborde, Kaylee Myhre title: Factors that enable effective One Health collaborations - A scoping review of the literature date: 2019-12-04 words: 9216 flesch: 32 summary: In the analysis, the research uncovered 12 factors that supported successful health event response. This is particularly impactful given that the absence of these resources and actions was noted across the literature as challenges to effective health response. keywords: articles; collaboration; efforts; event; factors; health; literature; network; process; research; response; review; support; team; training cache: cord-004017-gcmpatlb.txt plain text: cord-004017-gcmpatlb.txt item: #210 of 672 id: cord-004068-d66lwylf author: Shimoda, Tomoko title: Effect of thermal control of dry fomites on regulating the survival of human pathogenic bacteria responsible for nosocomial infections date: 2019-12-27 words: 4678 flesch: 36 summary: Other factors such as UV radiation, humidity, the presence of organic materials, and surface type are known to be associated with the ability of Thermal control of dry fomites and bacterial survival bacteria responsible for hospital-acquired infections to survive on dry surfaces It is therefore possible that there are other unknown factors responsible for bacterial survival, particularly on dry surfaces, in hospitals. keywords: aureus; bacteria; coli; hospital; surfaces; survival; temperature cache: cord-004068-d66lwylf.txt plain text: cord-004068-d66lwylf.txt item: #211 of 672 id: cord-004091-gex0zvoa author: Abdulkareem, Shaheen A. title: Risk perception and behavioral change during epidemics: Comparing models of individual and collective learning date: 2020-01-06 words: 8381 flesch: 48 summary: Even in M2, there were limitations of making decisions about risk perceptions individually: risk perception fell too quickly, implying that people stopped worrying about the epidemics although they continued. key: cord-004091-gex0zvoa authors: Abdulkareem, Shaheen A.; Augustijn, Ellen-Wien; Filatova, Tatiana; Musial, Katarzyna; Mustafa, Yaseen T. title: Risk perception and behavioral change during epidemics: Comparing models of individual and collective learning date: 2020-01-06 journal: PLoS One DOI: 10.1371/journal.pone.0226483 sha: doc_id: 4091 cord_uid: gex0zvoa Modern societies are exposed to a myriad of risks ranging from disease to natural hazards and technological disruptions. keywords: agents; disease; fig; group; household; individual; information; learning; perception; process; risk cache: cord-004091-gex0zvoa.txt plain text: cord-004091-gex0zvoa.txt item: #212 of 672 id: cord-010368-plpghewn author: Kenmoe, Sebastien title: Association of early viral lower respiratory infections and subsequent development of atopy, a systematic review and meta-analysis of cohort studies date: 2020-04-24 words: 3927 flesch: 35 summary: Included studies were prospective and retrospective cohorts with a minimum follow-up duration of one year. In accordance with Newcastle-Ottawa Scale (NOS) criteria including patient selection, comparability of groups, and outcome evaluation, two independent researchers (KS and AFM) assessed the quality of all included studies [26] (S2 Table) . keywords: atopy; development; lrti; review; serum; studies; years cache: cord-010368-plpghewn.txt plain text: cord-010368-plpghewn.txt item: #213 of 672 id: cord-010369-x9z8dg6a author: Saito, Kyoko title: Comparative characterization of flavivirus production in two cell lines: Human hepatoma-derived Huh7.5.1-8 and African green monkey kidney-derived Vero date: 2020-04-24 words: 5049 flesch: 53 summary: In the course of the Comparison of flavivirus production between Huh7.5.1-8 and Vero cell lines infection, plaques in Huh7.5.1-8 cells grew more rapidly than those in Vero cells. Codon 55 of RIG-I gene of Huh7.5.1 cells was heterozygous as was that of Huh7.5.1-8 cells, showing that the heterozygosity of the codon was stable at least during the time span for isolation of the Huh7.5.1-8 clone from Huh7.5.1 cells. keywords: cells; fig; huh7.5.1; infection; jev; line; plaque; rna; vero; virus cache: cord-010369-x9z8dg6a.txt plain text: cord-010369-x9z8dg6a.txt item: #214 of 672 id: cord-011496-r8e19t0c author: de Rooij, Doret title: Development of a competency profile for professionals involved in infectious disease preparedness and response in the air transport public health sector date: 2020-05-21 words: 7600 flesch: 37 summary: Although competency profiles for infectious disease control professionals are available, none addresses the complex airport environment. This method is commonly used for the development of competency profiles keywords: airport; competencies; competency; competency profile; disease; health; international; management; participants; preparedness; professionals; profile; public; response cache: cord-011496-r8e19t0c.txt plain text: cord-011496-r8e19t0c.txt item: #215 of 672 id: cord-011798-uss38ped author: Li, Guowei title: Intellectual capital and the efficiency of SMEs in the transition economy China; Do financial resources strengthen the routes? date: 2020-07-02 words: 8760 flesch: 35 summary: For instance, Fonseka et al, [31] demonstrate that out of many resources, financial capital is the most prominent for SMEs in emerging economies. For instance, Penrose, [85] securitizes that a firm's resources such as financial capital, talented managers and knowledge etc. are the key inputs into the production process, value creation and high efficiency. keywords: advantage; business; capital; customer; customer capital; efficiency; firm; intellectual; performance; research; resources; role; smes cache: cord-011798-uss38ped.txt plain text: cord-011798-uss38ped.txt item: #216 of 672 id: cord-011857-brbqgbpz author: Beasley, Steven A. title: An Angelman syndrome substitution in the HECT E3 ubiquitin ligase C-terminal Lobe of E6AP affects protein stability and activity date: 2020-07-08 words: 4499 flesch: 43 summary: The same sample was used afterwards to obtain a melting curve of the mutant monitoring changes in α-helical content at 222 nm over a temperature range of 5-90˚C, temperature slope 1˚C/min, data pitch 0.3, response 4 seconds, bandwidth 1 nm, sensitivity standard 100 mdeg, and voltage of 600 mV. Ubiquitination assays were conducted with 10 μM Alexa Fluor 647 N-terminally labeled ubiquitin, 10 μM E1 activating enzyme UBE1 (Uba1), 15 μM E2 conjugating enzyme UBE2L3 (UbcH7), and E3 ligase (35 μM E6AP C-lobe or E6AP HECT , as well as their variants), 2 μM DTT, 20 mM ATP, 40 mM MgCl 2 in 50 mM HEPES pH 7.5, 100 mM NaCl. Cancer Metastasis Rev E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53 A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18 Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade Polyubiquitination by HECT E3s and the determinants of chain type specificity HECT E3 ubiquitin ligases: emerging insights into their biological roles and disease relevance Angelman syndrome protein UBE3A interacts with primary microcephaly protein ASPM, localizes to centrosomes and regulates chromosome segregation Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6 Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination E6AP and calmodulin reciprocally regulate estrogen receptor stability Identification of annexin A1 as a novel substrate for E6AP-mediated ubiquitylation The spectrum of mutations in UBE3A causing Angelman syndrome Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein The Angelman syndromeassociated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily Novel mutations of ubiquitin protein ligase 3A gene in Italian patients with Angelman syndrome Design parameters to control synthetic gene expression in Escherichia coli Designing genes for successful protein expression Gene Designer: a synthetic biology tool for constructing artificial DNA segments Simple and efficient site-directed mutagenesis using two singleprimer reactions in parallel to generate mutants for protein structure-function studies Pure absorption gradient enhanced heteronuclear single quantum correlation spectroscopy with improved sensitivity Internal pH indicators for biomolecular NMR An efficient experiment for sequential backbone assignment of medium-sized isotopically enriched proteins Correlating backbone amide and side chain resonances in larger proteins by multiple relayed triple resonance NMR Three-dimensional triple-resonance NMR Spectroscopy of isotopically enriched proteins Gradient-enhanced triple-resonance three-dimensional NMR experiments with improved sensitivity Improved 3D triple-resonance NMR techniques applied to a 31 kDa protein An efficient 3D NMR technique for correlating the proton and 15N backbone amide resonances with the alpha-carbon of the preceding residue in uniformly 15N/13C enriched proteins A constant-time three-dimensional triple-resonance pulse scheme to correlate intraresidue 1HN, 15N, and 13C 0 keywords: angelman; e6ap; hect; i827k; ligase; lobe; nmr; protein; ube3a; ubiquitin cache: cord-011857-brbqgbpz.txt plain text: cord-011857-brbqgbpz.txt item: #217 of 672 id: cord-012387-1ogcxd7b author: Kaufman, Aaron R. title: The political consequences of opioid overdoses date: 2020-08-04 words: 2958 flesch: 43 summary: In contrast to other studies examining the effects of tragedy on political participation, we find that friends and family of opioid overdose victims are less likely to turn out to vote than they were before tragedy struck, even compared to victims of premature cancer or a demographically-matched sample of registrants without familial opioid overdoses. How might friends and family of opioid overdose victims respond politically? keywords: cancer; family; friends; opioid; overdose; party; victims cache: cord-012387-1ogcxd7b.txt plain text: cord-012387-1ogcxd7b.txt item: #218 of 672 id: cord-012461-v8d91fdo author: Marnissi, Boutheina title: Generation of ssDNA aptamers as diagnostic tool for Newcastle avian virus date: 2020-08-13 words: 6116 flesch: 47 summary: DNA polymerase Aptasensors as the future of antibiotics test kits-a case study of the aptamer application in the chloramphenicol detection New Prostate Cancer Targets for Diagnosis, Imaging, and Therapy: Focus on Prostate-Specific Membrane Antigen Screening of nucleic acid aptamer of lung cancer cells based on cell exponential enrichment ligand system evolution and its application in tumor diagnosis and treatment Rapid and highly sensitive method for influenza A (H1N1) virus detection Exploiting enzyme catalysis in ultra-low ion strength media for impedance biosensing of avian influenza virus using a bare interdigitated electrode A novel method for detection of H9N2 influenza viruses by an aptamer-real time-PCR Advancements in Nucleic Acid Based Therapeutics against Respiratory Viral Infections One round of SELEX for the generation of DNA aptamers directed against KLK6 A combined enrichment and aptamer pulldown assay for Francisella tularensis detection in food and environmental matrices FASTAptamer: A Bioinformatic Toolkit for High-throughput Sequence Analysis of Combinatorial Selections Development of a real-time reverse-transcription PCR for detection of newcastle disease virus RNA in clinical samples Limit of blank, limit of detection and limit of quantitation Investigations on the interface of nucleic acid aptamers and binding targets Increased inhibitory ability of conjugated RNA aptamers against the HCV IRES Evolution of a T7 RNA polymerase variant that transcribes 2'-Omethyl RNA New NTP analogs: the synthesis of 4'-thioUTP and 4'-thioCTP and their utility for SELEX Magnetic Separation-Based Multiple SELEX for Effectively Selecting Aptamers against Saxitoxin, Domoic Acid, and Tetrodotoxin Selection of aptamers by systematic evolution of ligands by exponential enrichment: addressing the polymerase chain reaction issue Emulsion PCR: a high efficient way of PCR amplification of random DNA libraries in aptamer selection Development and validation of a new PCR optimization method by combining experimental design and artificial neural network Optimization and troubleshooting in PCR Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencing Selection, Characterization and Interaction Studies of a DNA Aptamer for the Detection of Bifidobacterium bifidum Identification and application of ssDNA aptamers against H(3)(7)Rv in the detection of Mycobacterium tuberculosis A self-assemble aptamer fragment/target complex based high-throughput colorimetric aptasensor using enzyme linked aptamer assay A colorimetric sandwich-type assay for sensitive thrombin detection based on enzymelinked aptamer assay Aptamers as a replacement for antibodies in enzyme-linked immunosorbent assay. The first step was the elution of high affinity aptamers using high concentration of NaCl. keywords: affinity; aptamers; detection; dna; elaa; ndv; pbs; pcr; samples; sandwich; selex; vaccine; virus cache: cord-012461-v8d91fdo.txt plain text: cord-012461-v8d91fdo.txt item: #219 of 672 id: cord-012889-dtil5xeo author: Holzer, Joshua title: The effect of copartisan justice ministers on human rights in presidential democracies date: 2020-09-02 words: 7298 flesch: 43 summary: Prime Ministers: How the Separation of Powers Affects Party Organization and Behavior The accountability deficit in Latin America The Cingranelli-Richards (CIRI Index) Human Rights Dataset The Political Terror Scale The Political Terror Scale (PTS): A re-introduction and a comparison to CIRI Index Are Global Human Rights Conditions Static or Improving? Electoral rules and incentives to protect human rights Principals, agents and human rights Is Religion the Enemy of Human Rights? Information effects and human rights data: Is the good news about increased human rights information bad news for human rights measures? Respect for human rights has improved over time: The effect of copartisan justice ministers on human rights in presidential democracies PLOS ONE | https://doi.org/10.1371/journal.pone.0234938 September 2, 2020 13 / 17 When justice answers to the president: Reexamining the effect of cabinet partisanship on human rights in presidential democracies Uncovering patterns among latent variables: Human rights and de facto judicial independence Constitutionalism and Rights: The Influence of the United States Constitution Abroad. keywords: ciri; copartisan; government; independence; index; justice; minister; president; respect; rights; scores cache: cord-012889-dtil5xeo.txt plain text: cord-012889-dtil5xeo.txt item: #220 of 672 id: cord-012891-heqsfzkm author: Blanco Vázquez, Cristina title: Detection of latent forms of Mycobacterium avium subsp. paratuberculosis infection using host biomarker-based ELISAs greatly improves paratuberculosis diagnostic sensitivity date: 2020-09-03 words: 7838 flesch: 38 summary: Logistic regression analysis indicated that biomarker FAM84A was excluded and biomarkers DES, ABCA13, MMP8 and SPARC-based ELISAs included in the diagnostic model for discrimination of infected animals and non-infected control animals. Up-regulation of MMP-8 expression in peripheral blood of MAP infected animals may indicate that MMP-8 plays an important role in the inflammation and destruction of tissue observed in the development of PTB. SPARC, also known as osteonectin, is a matrix protein that binds collagen, and is required for the development of granuloma-like structures during chronic infections keywords: abca13; animals; control; detection; diffuse; elisa; fecal; lesions; map; mmp8; ptb; sensitivity; sparc cache: cord-012891-heqsfzkm.txt plain text: cord-012891-heqsfzkm.txt item: #221 of 672 id: cord-012967-w1oc0wdd author: Eberle, Jaelyn J. title: Using tooth enamel microstructure to identify mammalian fossils at an Eocene Arctic forest date: 2020-09-23 words: 5902 flesch: 50 summary: The techniques for preparing and studying tooth enamel microstructure of large fossil mammals were described by [19] and are summarized here. Additionally, when studied under SEM, the enamel of NUFV2092B and 2092E has rounded prisms that open to one side and are surrounded by interprismatic matrix that is nearly parallel to the prisms, which also occurs in Coryphodon enamel, based on prior studies. keywords: 2092e; arctic; coryphodon; enamel; eocene; fiord; formation; fossil; microstructure; nufv; prisms; tooth cache: cord-012967-w1oc0wdd.txt plain text: cord-012967-w1oc0wdd.txt item: #222 of 672 id: cord-013099-j816c3tw author: Blease, Charlotte title: US primary care in 2029: A Delphi survey on the impact of machine learning date: 2020-10-08 words: 5705 flesch: 49 summary: key: cord-013099-j816c3tw authors: Blease, Charlotte; Kharko, Anna; Locher, Cosima; DesRoches, Catherine M.; Mandl, Kenneth D. title: US primary care in 2029: A Delphi survey on the impact of machine learning date: 2020-10-08 journal: PLoS One DOI: 10.1371/journal.pone.0239947 sha: doc_id: 13099 cord_uid: j816c3tw OBJECTIVE: To solicit leading health informaticians’ predictions about the impact of AI/ML on primary care in the US in 2029. This study presents timely information on informaticians’ consensus views about the impact of AI/ML on US primary care in 2029. keywords: care; consensus; delphi; experts; health; participants; round; survey cache: cord-013099-j816c3tw.txt plain text: cord-013099-j816c3tw.txt item: #223 of 672 id: cord-013263-xw611i8k author: Dederichs, Melina title: Students’ perspectives on interventions to reduce stress in medical school: A qualitative study date: 2020-10-15 words: 5663 flesch: 48 summary: Evidence-based mental health Mindfulness interventions in medical education: A systematic review of their impact on medical student stress, depression, fatigue and burnout Association Between Learning Environment Interventions and Medical Student Well-being: A Systematic Review The benefits of pass-fail grading on stress, mood, and group cohesion in medical students Impact of pass/fail grading on medical students' well-being and academic outcomes Differences in Medical Students' Academic Performance between a Pass/Fail and Tiered Grading System A systematic review of the literature describing the outcomes of nearpeer mentoring programs for first year medical students Introducing first-year students to medical school: experiences at the Faculty of Medicine of Erasmus University Students helping students: vertical peer mentoring to enhance the medical school experience The doctor, his patient and the illness Research on Balint groups: a literature review The impact of a physician awareness group and the first year of training on hematology-oncology fellows Stressors perceived by the para-clinical undergraduate medical students Teaching the clinical encounter in psychiatry: a trial of Balint groups for medical students Reflecting on our practice: an evaluation of Balint groups for medical students in psychiatry A qualitative analysis of student Balint groups in medical education: contexts and triggers of case presentations and discussion themes. The mental health of medical students remains to be a matter of concern. keywords: fail; focus; groups; interventions; medical; pass; stress; students; study cache: cord-013263-xw611i8k.txt plain text: cord-013263-xw611i8k.txt item: #224 of 672 id: cord-013265-qrfi6e5c author: Isono, Toshihito title: Treatment of severe pneumonia by hinokitiol in a murine antimicrobial-resistant pneumococcal pneumonia model date: 2020-10-15 words: 4594 flesch: 34 summary: Taken together, these findings suggested that the antibacterial action of hinokitiol in the lungs of pneumonia mice reduced the production of cytokines or chemokines in BALF and serum. In this study, intratracheal hinokitiol administration reduced neutrophil infiltration and elastase release in the lungs of pneumonia mice, consequently diminishing lung injury and pneumococcal DNA detection in serum. keywords: administration; balf; group; hinokitiol; infection; lung; mice; pbs; pneumonia; serum; treatment cache: cord-013265-qrfi6e5c.txt plain text: cord-013265-qrfi6e5c.txt item: #225 of 672 id: cord-013333-7jx4t0ol author: Palloni, Alberto title: Impacts of the 1918 flu on survivors' nutritional status: A double quasi-natural experiment date: 2020-10-20 words: 10570 flesch: 48 summary: The parameter θ k measures the difference of effects of flu exposure between those born in high and low severity municipios whereas the difference of effects of exposure between those born in municipios affected by the earthquake and those born in the remaining municipios is, δ The F-test indicates that the total effect of flu exposure is statistically significant (prF o >F � = 79.13 is .0002). keywords: areas; conditions; earthquake; effects; exposure; females; flu; flu severity; growth; height; knee height; municipios; pandemic; severity cache: cord-013333-7jx4t0ol.txt plain text: cord-013333-7jx4t0ol.txt item: #226 of 672 id: cord-013334-cptu0k7s author: Holst-Hansen, Joachim A. title: Does the size of rewards influence performance in cognitively demanding tasks? date: 2020-10-21 words: 6102 flesch: 52 summary: The correlation between high reward and performance was 0.125 in our study, and with this correlation we would have required a sample size of 247 to obtain a p-value below 0.05, if relying on a simple linear regression. While we cannot rule out the existence of a small positive effect of high rewards, our study reduces the prior belief one should have in the replicability of former, relatively large effect sizes, in either direction. keywords: effect; effort; motivation; participants; performance; reward; size; studies; tasks cache: cord-013334-cptu0k7s.txt plain text: cord-013334-cptu0k7s.txt item: #227 of 672 id: cord-013356-y6vceq2x author: Peace, Angela title: Orchard layout and plant traits influence fruit yield more strongly than pollinator behaviour and density in a dioecious crop date: 2020-10-23 words: 5865 flesch: 50 summary: Within this window, pollen availability is typically not a limiting factor in kiwifruit due to male flowers having up to twice as many pollen grains than female flowers, and the anthers continued to dehisce over this four-hour period. These probabilities depend on the ratio of male to female flowers raised to the power of the preference, such that the movement of pollinators between flowers can be written as the following expressions: 1 À m f þ m � � d fraction on male flowers that move to a female flower ð4bÞ � ε fraction on female flowers that move to a female flower ð4cÞ � ε fraction on female flowers that move to a male flower ð4dÞ Values for strong preferences were used for the analyses in this paper, details are described in the Parameterization section. keywords: ffl ffl; flowers; fruit; kiwifruit; male; model; number; pollinator; total; yield cache: cord-013356-y6vceq2x.txt plain text: cord-013356-y6vceq2x.txt item: #228 of 672 id: cord-048339-nzh87aux author: Caley, Peter title: The Waiting Time for Inter-Country Spread of Pandemic Influenza date: 2007-01-03 words: 5747 flesch: 41 summary: To this end, countries may consider introducing non-pharmaceutical interventions such as border screening, promoting early presentation of cases among arriving passengers, requiring the use of personal protective equipment during travels (e.g. the wearing of masks), and reducing traveler numbers. We also investigate how the delay is affected by the reproduction number of the emerged strain, early presentation of cases among arriving passengers, and reducing traveler numbers. keywords: country; delay; epidemic; flight; number; region; source cache: cord-048339-nzh87aux.txt plain text: cord-048339-nzh87aux.txt item: #229 of 672 id: cord-048353-hqc7u9w3 author: Chis Ster, Irina title: Transmission Parameters of the 2001 Foot and Mouth Epidemic in Great Britain date: 2007-06-06 words: 6400 flesch: 50 summary: When fitting models with time varying infectivity parameters we actually fit I post and the ratio m This may seem paradoxical but reflects the fact that while culling (the effect of which is explicitly included in the input data) dramatically reduced case incidence in April, from May to September 2001, case incidence maintained itself at a low level -but almost entirely within cattle farms. keywords: cattle; epidemic; farms; infected; infection; infectivity; model; parameters; sheep; species; time cache: cord-048353-hqc7u9w3.txt plain text: cord-048353-hqc7u9w3.txt item: #230 of 672 id: cord-048358-z5klydpi author: Catic, André title: Screen for ISG15-crossreactive Deubiquitinases date: 2007-07-25 words: 5371 flesch: 40 summary: The solution was mixed thoroughly and to this was added ISG15 activating enzyme (Boston Biochem, ISG15 E1, 50 nM final) and UbcH8 (Boston Biochem, 250 nM final), or SUMO activating enzyme (SAE1/SAE2 heterodimer, 50 nM final) and UbcH9 (250 nM final). USP2 exhibits oncogenic potential in prostate cancer by stabilizing its substrate Fatty Acid Synthase (FAS) [38] , and FAS has indeed been identified as a target of ISG15 modification [39] . keywords: activity; dubs; enzyme; figure; human; isg15; isg15vs; probes; proteases; proteasome; proteins; ubiquitin; usp14; usp5 cache: cord-048358-z5klydpi.txt plain text: cord-048358-z5klydpi.txt item: #231 of 672 id: cord-048360-n9sih438 author: Villard, Viviane title: Rapid Identification of Malaria Vaccine Candidates Based on α-Helical Coiled Coil Protein Motif date: 2007-07-25 words: 4797 flesch: 41 summary: Found at: doi:10.1371/journal.pone.0000645.s005 (0.05 MB DOC) Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing Reverse vaccinology and genomics Plasmodium falciparum liver stage antigen-1 is well conserved and contains potent B and T cell determinants Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3 Phase I malaria vaccine trial with a long synthetic peptide derived from the merozoite surface protein 3 antigen Plasmodium falciparum merozoite surface protein 6 displays multiple targets for naturally occurring antibodies that mediate monocyte-dependent parasite killing Template-based coiled-coil antigens elicit neutralizing antibodies to the SARS-coronavirus Phase 1 randomized double-blind safety and immunogenicity trial of Plasmodium falciparum malaria merozoite surface protein FMP1 vaccine De novo design of alpha-helical proteins: basic research to medical applications Genome sequence of the human malaria parasite Plasmodium falciparum A flexible motif search technique based on generalized profiles Transcriptomics and proteomics: tools for the identification of novel drug targets and vaccine candidates for tuberculosis A proteomic view of the Plasmodium falciparum life cycle The Transcriptome of the Intraerythrocytic Developmental Cycle of Plasmodium falciparum Crossreactive antigens between life cycle stages of plasmodium falciparum Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes Mapping of conformational B cell epitopes within alpha-helical coiled coil proteins A de novo designed template for generating conformation-specific antibodies that recognize alpha-helices in proteins Targeting malaria virulence and remodeling proteins to the host erythrocyte A host-targeting signal in virulence proteins reveals a secretome in malarial infection Proteomic analysis identifies novel proteins of the Maurer's clefts, a secretory compartment delivering Plasmodium falciparum proteins to the surface of its host cell Multi-character population study of the vir subtelomeric multigene superfamily of Plasmodium vivax, a major human malaria parasite A Maurer's cleft-associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells A novel antibody-dependent cellular cytotoxicity mechanism involved in defense against malaria requires costimulation of monocytes FcgammaRII and FcgammaRIII Predicting coiled coils from protein sequences Improved prediction of signal peptides: SignalP 3.0 TMbase-A database of membrane spanning proteins segments Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes Prediction of potential GPImodification sites in proprotein sequences pTARGET Figure S1 CD spectra of the peptides 45 (S1A) and 12 (S1B) Found at: doi:10.1371/journal.pone.0000645.s001 (12.32 MB TIF) Figure S2 ELISA inhibition assay using anti-human peptide specific antibodies. keywords: antibodies; assays; blood; coil; falciparum; human; malaria; parasite; peptides; proteins; sera; specific; table; vaccine cache: cord-048360-n9sih438.txt plain text: cord-048360-n9sih438.txt item: #232 of 672 id: cord-048364-yfn8sy1m author: Fraser, Christophe title: Estimating Individual and Household Reproduction Numbers in an Emerging Epidemic date: 2007-08-22 words: 9061 flesch: 40 summary: The structure of the paper focuses first on deriving estimators for individual reproduction numbers, then on household reproduction numbers and finally on examples of pandemic influenza dynamics and measles. One approach to estimating household reproduction numbers is simply to switch perspective from individual to household, directly estimate the generation time distribution (times taken for one household to infect another) and incidence of infection of households, and apply the results of equations (9) or (12) to estimate reproduction number as a function of time, R * (t), or exponential growth rate, R * (r). keywords: household; infection; number; reproduction; reproduction number; time; time t; transmission cache: cord-048364-yfn8sy1m.txt plain text: cord-048364-yfn8sy1m.txt item: #233 of 672 id: cord-048367-yya6w976 author: Jónsson, Stefán R. title: The Restriction of Zoonotic PERV Transmission by Human APOBEC3G date: 2007-09-12 words: 5949 flesch: 47 summary: Here, long-term co-culture experiments were used to show that porcine endogenous retrovirus (PERV) transmission from pig to human cells is reduced to nearly undetectable levels by expressing human APOBEC3G in virus-producing pig kidney cells. For instance, human APOBEC3G can potently inhibit the replication of SIV (except isolates such as SIV cpz which encode a Vif protein closely related to that of HIV-1), feline foamy virus and MLV (e.g., [17] [18] [19] [20] 25, 26, 39, 41, 42] ). keywords: apobec3; cells; data; dna; figure; gene; human; pcr; perv; pig; transmission; virus cache: cord-048367-yya6w976.txt plain text: cord-048367-yya6w976.txt item: #234 of 672 id: cord-048446-gaemgm0t author: White, Laura Forsberg title: Transmissibility of the Influenza Virus in the 1918 Pandemic date: 2008-01-30 words: 3736 flesch: 44 summary: Using a likelihood-based method and a nonparametric method, we estimate the serial interval and reproductive number throughout the course of each outbreak. Preliminary statistics of certain locations A likelihood based method for real time estimation of the serial interval and reproductive number of an epidemic A flexible growth function for empirical use Radioligand Assay Statistical analysis of radioimmunoassay data These results confirm the high pathogenicity of influenza and its ability to rapidly spread through populations. keywords: data; estimates; influenza; interval; method; number cache: cord-048446-gaemgm0t.txt plain text: cord-048446-gaemgm0t.txt item: #235 of 672 id: cord-048471-7jszm1nd author: Salim, Omar title: Functional Analysis of the 5′ Genomic Sequence of a Bovine Norovirus date: 2008-05-14 words: 5667 flesch: 44 summary: To date, it has not been possible to explain the difference in the predicted and observed sizes for the JV N-term, and the addition of the 14 amino acid V5 epitope within JV N-term does not account for this apparent large shift in molecular weight. It cannot be ruled out, however, that the wild type JV N-term aberrantly co-migrates with the 39 kDa JV 2C protein in SDS-PAGE. keywords: cells; initiation; ires; kda; protein; rna; term; translation; virus cache: cord-048471-7jszm1nd.txt plain text: cord-048471-7jszm1nd.txt item: #236 of 672 id: cord-048477-ze511t38 author: Patel, Mahomed S. title: General Practice and Pandemic Influenza: A Framework for Planning and Comparison of Plans in Five Countries date: 2008-05-28 words: 6919 flesch: 36 summary: In an analysis of pandemic influenza plans in Asia-Pacific countries in 2006, Coker found that although all countries recognised the importance of pandemic planning, operational responsibility particularly at the local level, remained unclear; most plans relied on specialised flu hospitals, while few developed the possibility of caring for patients at home Accessed 13 Arkansas responds: Arkansas pandemic influenza response plan Pandemic influenza plan Influenza pandemic preparedness plan Pandemic influenza plan Public health pandemic influenza plan Virginia emergency operations plan attachment pandemic influenza HHS pandemic influenza plan Ontario health plan for an influenza pandemic Surveillance of influenza-like illness in England and Wales during 1966-2006 keywords: care; countries; framework; health; influenza; pandemic; planning; plans; practice; preparedness; primary; public; response; system cache: cord-048477-ze511t38.txt plain text: cord-048477-ze511t38.txt item: #237 of 672 id: cord-048483-umvrwgaw author: van der Sande, Marianne title: Professional and Home-Made Face Masks Reduce Exposure to Respiratory Infections among the General Population date: 2008-07-09 words: 3816 flesch: 44 summary: Regardless of mask type, children were less well protected. The logit transformation is a standard transformation to transform the probability scale (0,1) to the real axis (-infinity, +infinity) to allow standard regression techniques (including ANOVA) to test the effects of co-variables (mask type, age class, sex, activity, duration of use) on transformed PFs in a linear model, using the statistical application R (version 2.5.0). keywords: factors; home; masks; protection; transmission; type; wearing cache: cord-048483-umvrwgaw.txt plain text: cord-048483-umvrwgaw.txt item: #238 of 672 id: cord-048492-4z38v9rg author: Tang, Julian W. title: Seasonality of Influenza A(H3N2) Virus: A Hong Kong Perspective (1997–2006) date: 2008-07-23 words: 4470 flesch: 41 summary: However, they did not have access to large numbers of influenza sequences from Southeast Asia. For all of these reasons, any investigation of the underlying basis for influenza seasonality may benefit greatly from a study of influenza viruses isolated from Hong Kong. keywords: a(h3n2; figures; hong; influenza; kong; seasonality; sequences; viruses cache: cord-048492-4z38v9rg.txt plain text: cord-048492-4z38v9rg.txt item: #239 of 672 id: cord-251979-j3mme15e author: Kandeel, Amr title: Morbidity, Mortality, and Seasonality of Influenza Hospitalizations in Egypt, November 2007-November 2014 date: 2016-09-08 words: 4721 flesch: 39 summary: The aims of this study were to (1) assess the proportion of SARI cases having influenza infection in Egypt; (2) examine the types and subtypes of detected influenza viruses in Egypt; (3) compare demographic and clinical characteristics of influenza-positive SARI cases to those of influenza-negative SARI cases in Egypt; (4) quantify influenza deaths and assess influenza mortality risk factors in Egypt; and (5) establish a defined period of influenza seasonality in Egypt. Regardless, patients with influenza infection comprised 19% of total SARI deaths. keywords: cases; data; egypt; hospitalization; infection; influenza; patients; sari; surveillance; years cache: cord-251979-j3mme15e.txt plain text: cord-251979-j3mme15e.txt item: #240 of 672 id: cord-252347-vnn4135b author: Lee, Wai-Ming title: A Diverse Group of Previously Unrecognized Human Rhinoviruses Are Common Causes of Respiratory Illnesses in Infants date: 2007-10-03 words: 5718 flesch: 46 summary: Selection of the target region To identify a genomic region suitable for molecular typing of HRV, we analyzed all published HRV sequences. These results suggested HRV serotypes are stable and do not undergo influenza virus-like antigenic drift [7] . keywords: hrv; hrvs; human; new; pcr; region; sequences; serotypes; strains cache: cord-252347-vnn4135b.txt plain text: cord-252347-vnn4135b.txt item: #241 of 672 id: cord-252739-1manzf3l author: Zheng, Yueming title: Hexachlorophene Is a Potent KCNQ1/KCNE1 Potassium Channel Activator Which Rescues LQTs Mutants date: 2012-12-12 words: 4019 flesch: 52 summary: Both potentiate homomeric KCNQ1 channel but lack sensitivity to the KCNQ1/KCNE1 complex. KCNQ potassium channels: physiology, pathophysiology, and pharmacology K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel Mechanisms of I(Ks) suppression in LQT1 mutants Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias Spectrum of mutations in long-QT syndrome genes KCNQ1 gene mutations and the respective genotype-phenotype correlations in the long QT syndrome Neural KCNQ (Kv7) channels Activation of Kv7 (KCNQ) voltagegated potassium channels by synthetic compounds Activation of KCNQ2/3 potassium channels by novel pyrazolo [1,5-a] pyrimidin-7(4H)-one derivatives The therapeutic potential of neuronal KV7 (KCNQ) channel modulators: an update Kv7 channels as targets for the treatment of pain Desensitization of chemical activation by auxiliary subunits: convergence of molecular determinants critical for augmenting KCNQ1 potassium channels A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties Discovery of a Novel Activator of KCNQ1-KCNE1 K+ Channel Complexes Soap bacteriostats Mitochondrial ATPsensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells The genetic basis of long QT and short QT syndromes: a mutation update Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits Impaired KCNQ1-KCNE1 and phosphatidylinositol-4,5-bisphosphate interaction underlies the long QT syndrome Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV Inhibition of the Staphylococcus aureus NADPH-dependent enoyl-acyl carrier protein reductase by triclosan and hexachlorophene Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels The role of the IsK protein in the specific pharmacological properties of the IKs channel complex Stilbenes and fenamates rescue the loss of I(KS) channel function induced by an LQT5 mutation and other IsK mutants Molecular biology of arrhythmic syndromes Pathophysiological mechanisms of dominant and recessive KVLQT1 K+ channel mutations found in inherited cardiac arrhythmias Novel mutations in KvLQT1 that affect Iks activation through interactions with Isk Characterization and subcellular localization of KCNQ1 with a heterozygous mutation in the C terminus Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate PIP2 is a necessary cofactor for ion channel function: how and why? keywords: channels; complex; current; effects; hcp; kcnq1; lqts; potential cache: cord-252739-1manzf3l.txt plain text: cord-252739-1manzf3l.txt item: #242 of 672 id: cord-252795-x66zqmgv author: Islam, Md. Akhtarul title: Depression and anxiety among university students during the COVID-19 pandemic in Bangladesh: A web-based cross-sectional survey date: 2020-08-26 words: 4014 flesch: 41 summary: Tanvir title: Depression and anxiety among university students during the COVID-19 pandemic in Bangladesh: A web-based cross-sectional survey date: 2020-08-26 journal: PLoS One DOI: 10.1371/journal.pone.0238162 sha: doc_id: 252795 cord_uid: x66zqmgv The purpose of this study was to investigate the prevalence of depression and anxiety among Bangladeshi university students during the COVID-19 pandemic. It is expected that both the government and universities could work together to fix the academic delays and financial problems to reduce depression and anxiety among university students. keywords: anxiety; covid-19; depression; health; mental; students; study; university cache: cord-252795-x66zqmgv.txt plain text: cord-252795-x66zqmgv.txt item: #243 of 672 id: cord-252838-av7ducrk author: Lucchi, Naomi W. title: Real-Time Fluorescence Loop Mediated Isothermal Amplification for the Diagnosis of Malaria date: 2010-10-29 words: 4917 flesch: 49 summary: The sensitivity and specificity of RealAmp method was calculated using both microscopy and a nested PCR assay We compared DNA obtained by the standard Qiagen method of DNA isolation and that obtained by direct heating for their performance in RealAmp method. keywords: amplification; dna; falciparum; malaria; method; pcr; realamp; samples cache: cord-252838-av7ducrk.txt plain text: cord-252838-av7ducrk.txt item: #244 of 672 id: cord-253056-765rs3e7 author: Dionne, Audrey title: Profile of resistance to IVIG treatment in patients with Kawasaki disease and concomitant infection date: 2018-10-17 words: 3727 flesch: 41 summary: Although concomitant infection does not affect coronary outcome, it is unknown how it influences the response to IVIG treatment. Retrospective cohort study between 2008 and 2016 in a tertiary pediatric university hospital, including 154 children, of which 59 (38%) had concomitant infection. keywords: children; infection; ivig; patients; treatment cache: cord-253056-765rs3e7.txt plain text: cord-253056-765rs3e7.txt item: #245 of 672 id: cord-253436-dz84icdc author: Wille, Michelle title: High Prevalence and Putative Lineage Maintenance of Avian Coronaviruses in Scandinavian Waterfowl date: 2016-03-03 words: 2020 flesch: 46 summary: Influenza A virus, avian paramyxovirus and avian coronavirus Multiple Alignment of DNA Sequences with MAFFT Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods Estimating maximum likelihood phylogenies with PhyML SeaView Version 4: A Multiplatform Graphical User Interface for Sequence Alignment and Phylogenetic Tree Building FigTree v1.1.1: Tree figure drawing tool Diverse gammacoronaviruses detected in wild birds from Madagascar Detection and molecular characterization of infectious bronchitis-like viruses in wild bird populations Genetically diverse coronaviruses in wild bird populations of northern England Molecular identification and characterization of novel coronaviruses infecting graylag geese (Anser anser), feral pigeons (Columbia livia) and mallards (Anas platyrhynchos) Identification of avian coronavirus in wild aquatic birds of the central and eastern USA Surveillance of avian coronaviruses in wild bird populations of Korea Absence of coronaviruses, paramyxoviruses, and influenza A viruses in seabirds in the southwestern Indian Ocean Animal migration and infectious disease risk Juveniles and migrants as drivers for seasonal epizootics of avian influenza virus Global patterns of influenza a virus in wild birds The evolutionary genetics and emergence of avian influenza A viruses in wild birds Spatial, temporal, and species variation in prevalence of influenza A viruses in wild migratory birds We wish to thank and the duck trappers at Ottenby Bird Observatory and Jonas Waldenström for collecting and providing samples used in this study, Jonas Blomberg for kindly providing sequence, Mallard CoV sequences generated in this study are indicated with a filled circle and Scaup CoV sequences with an asterisk. We found a prevalence of 18.7% CoV, which is higher than the 0-15% reported previously in wild bird studies [11, 14, 15, [21] keywords: coronaviruses; cov; prevalence; sequences; species cache: cord-253436-dz84icdc.txt plain text: cord-253436-dz84icdc.txt item: #246 of 672 id: cord-254000-pbzcupjg author: Suvannachart, Pukkapol title: Repeatability, reproducibility, agreement, and safety of Tono-Pen tip cover for intraocular measurement using latex and polyethylene wrap date: 2020-09-28 words: 3629 flesch: 56 summary: PW tip cover was prepared by cutting the commercial PW to a size of 5 by 5 centimetres. The left eye of each participant was used to study the agreement between OF and PW tip covers and intra-observer repeatability of both types. keywords: agreement; cover; eyes; loa; repeatability; tip cache: cord-254000-pbzcupjg.txt plain text: cord-254000-pbzcupjg.txt item: #247 of 672 id: cord-254025-j1l0mder author: de Melo, Andreia C. title: Cancer inpatients with COVID-19: A report from the Brazilian National Cancer Institute date: 2020-10-26 words: 3385 flesch: 46 summary: Therefore, the overall COVID-19-related mortality rate reached almost one third of the cases (60 [33.1%]), which was higher than that reported by other series with cancer patients [7, 8, 10, 12, 14] , and far exceeding the mortality reported for non-cancer patients [5] . There was no paired sample with non-cancer patients with COVID-19 or cancer patients without COVID-19 to provide a better comparison between the outcomes of morbidity and mortality. keywords: cancer; cases; covid-19; death; mortality; patients; study cache: cord-254025-j1l0mder.txt plain text: cord-254025-j1l0mder.txt item: #248 of 672 id: cord-254117-2ttwaegh author: Priest, Patricia C. title: Thermal Image Scanning for Influenza Border Screening: Results of an Airport Screening Study date: 2011-01-05 words: 4187 flesch: 37 summary: Entry screening to delay local transmission of 2009 pandemic influenza A (H1N1) Revision of the International Health Regulations World Health Organisation Screening for fever by remote-sensing infrared thermographic camera Limitations of forehead infrared body temperature detection for fever screening for severe acute respiratory syndrome Analysis of IR thermal imager for mass blind fever screening Cutaneous infrared thermometry for detecting febrile patients World Health Organization Working Group on International and Community Transmission of SARS (2004) Public health interventions and SARS spread Thermal image scanners to detect fever in airline passengers, Vancouver and Toronto Border screening for SARS Investigation of the optimal assessment of febrile passengers detected by infrared thermal scanning at an international airport Epidemiology of travel-associated pandemic (H1N1) 2009 infection in 116 patients International travels and fever screening during epidemics: a literature review on the effectiveness and potential use of non-contact infrared thermometers Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review Screening for Influenza Infection in International Airline Travellers Manual for the surveillance of vaccine-preventable diseases Diagnostic tests 3: receiver operating characteristic plots Clinical signs and symptoms predicting influenza infection Predicting influenza infections during epidemics with use of a clinical case definition Diagnosis of influenza in the community: relationship of clinical diagnosis to confirmed virological, serologic, or molecular detection of influenza Time lines of infection and disease in human influenza: a review of volunteer challenge studies Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China Clinical diagnostic criteria for isolating patients admitted to hospital with suspected pandemic influenza Entry screening for severe acute respiratory syndrome (SARS) or influenza: policy evaluation We thank the Health Emergency Management Branch, Department of Health and Ageing, Australia for lending us the scanner; Christchurch International Airport Limited, New Zealand Customs Service, and the participating airlines for their cooperation and assistance; and Andrew Strathdee for the laboratory testing. The prevalence of fever is high in case series of patients with confirmed influenza infection [11, 21] , since often one of the criteria that is often used to determine whether testing takes place is the presence of fever. keywords: fever; infection; influenza; itis; screening; study; temperature; travellers cache: cord-254117-2ttwaegh.txt plain text: cord-254117-2ttwaegh.txt item: #249 of 672 id: cord-254313-g2oc32dm author: Klink, Thomas title: Evaluating the diagnostic accuracy of the WHO Severe Acute Respiratory Infection (SARI) criteria in Middle Eastern children under two years over three respiratory seasons date: 2020-04-30 words: 4501 flesch: 46 summary: Findings from a sentinel-based virological surveillance system for flu Estimation of flu and severe acute respiratory illness incidence (Burden) in three provinces of the Islamic Republic of Iran Viral etiology, seasonality and severity of hospitalized patients with severe acute respiratory infections in the Eastern Mediterranean Region Morbidity, mortality, and seasonality of flu hospitalizations in Egypt Incidence of flu virus-associated severe acute respiratory infection in Damanhour district Flu-associated severe acute respiratory infections in 2 sentinel sites in Lebanon Characteristics of severe acute respiratory infection associated hospitalization in Yemen Evaluation of the new world health organization case definition of severe acute respiratory infection for flu surveillance during the peak weeks of two flu seasons in Quebec Comparison of severe acute respiratory illness (sari) and clinical pneumonia case definitions for the detection of flu virus infections among hospitalized patients, western Kenya Evaluation of case definitions to detect respiratory syncytial virus infection in hospitalized children below 5 years in Rural Western Kenya Performance of Surveillance Case Definitions in Detecting Respiratory Syncytial Virus Infection Among Young Children Hospitalized with Severe Respiratory Illness-South Africa Evaluation of case definitions for estimation of respiratory syncytial virus associated hospitalizations among children in a rural community of northern India What are the most sensitive and specific sign and symptom combinations for flu in patients hospitalized with acute respiratory illness? Subjects meeting SARI criteria were determined post-hoc. keywords: age; children; criteria; flu; months; sari; virus cache: cord-254313-g2oc32dm.txt plain text: cord-254313-g2oc32dm.txt item: #250 of 672 id: cord-254340-e1x0z3rh author: Cruz, Christian Joy Pattawi title: Exploring the young demographic profile of COVID-19 cases in Hong Kong: Evidence from migration and travel history data date: 2020-06-26 words: 4969 flesch: 57 summary: Analysis of the travel histories of Hong Kong cases suggests that the majority of imported cases in the 15-24 age group may be Hong Kong residents who are studying or working abroad. By doing so, we highlight the importance of returnee Hong Kong residents from overseas hotspots on the relatively young age structure of confirmed cases during the second wave in March 2020. keywords: age; care; cases; covid-19; data; hong; hong kong; kong; population; travel cache: cord-254340-e1x0z3rh.txt plain text: cord-254340-e1x0z3rh.txt item: #251 of 672 id: cord-254825-c5d0wul9 author: Kim, Sei Won title: Containment of a healthcare-associated COVID-19 outbreak in a university hospital in Seoul, Korea: A single-center experience date: 2020-08-14 words: 3562 flesch: 46 summary: Severe symptoms develop in approximately 14% of COVID-19 patients, and the overall mortality is around 2% of confirmed COVID-19 cases [10] . Contact was defined as presence in the same room with COVID-19 confirmed patients, or in the same outpatient clinic or examination room, 30 minutes before and after COVID-19 confirmed patients. keywords: contact; cov-2; covid-19; hospital; outbreak; patients; pcr; sars cache: cord-254825-c5d0wul9.txt plain text: cord-254825-c5d0wul9.txt item: #252 of 672 id: cord-255013-njpuc475 author: He, Xiaocui title: Establishment of Myotis myotis Cell Lines - Model for Investigation of Host-Pathogen Interaction in a Natural Host for Emerging Viruses date: 2014-10-08 words: 4531 flesch: 46 summary: Euro surveillance : bulletin europeen sur les maladies transmissibles Fatal human rabies caused by European bat Lyssavirus type 2a infection in Scotland Emerging diseases in Chiroptera: why bats? Passive surveillance (1987 to 2004) of United Kingdom bats for European bat lyssaviruses Experimental Nipah virus infection in pteropid bats (Pteropus poliocephalus) Experimental hendra virus infectionin pregnant guinea-pigs and fruit Bats (Pteropus poliocephalus) Antiviral immune responses of bats: a review Transmission studies of Hendra virus (equine morbillivirus) in fruit bats, horses and cats Experimental study of European bat lyssavirus type-2 infection in Daubenton's bats (Myotis daubentonii) Bats and viruses: friend or foe? Pathogenesis studies with Australian bat lyssavirus in grey-headed flying foxes (Pteropus poliocephalus) Establishment, immortalisation and characterisation of pteropid bat cell lines Type I interferon reaction to viral infection in interferon-competent, immortalized cell lines from the African fruit bat Eidolon helvum Establishment of cell line from embryonic tissue of Pipistrellus ceylonicus bat species from India & its susceptibility to different viruses Bat airway epithelial cells: a novel tool for the study of zoonotic viruses Interferon production and signaling pathways are antagonized during henipavirus infection of fruit bat cell lines Anti-Lyssaviral Activity of Interferons kappa and omega from the Serotine Bat, Eptesicus serotinus White-nose syndrome fungus: a generalist pathogen of hibernating bats Standardized detection of Simian virus 40 by real-time quantitative polymerase chain reaction in pediatric malignancies Enhanced passive bat rabies surveillance in indigenous bat species from Germany -a retrospective study Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) A broader variety of bat cell lines, particularly European bat cell lines from tissues of immune relevance, is therefore urgently in demand for lyssavirus-host studies. keywords: bats; cell; expression; fig; ifn; infection; lines; lyssavirus; mmbr; myotis; virus cache: cord-255013-njpuc475.txt plain text: cord-255013-njpuc475.txt item: #253 of 672 id: cord-255351-vp19ydce author: Lanata, Claudio F. title: Global Causes of Diarrheal Disease Mortality in Children <5 Years of Age: A Systematic Review date: 2013-09-04 words: 5453 flesch: 43 summary: We stratified studies by the number of pathogens sought and calculated the unadjusted and age-adjusted medians, as described above, separately for single pathogen studies and for studies that sought 5 to 13 pathogens. GBD used rates reported in diarrhea studies published between 1975 and 2010 done in outpatients, casecontrol, and community-based studies as a reference category to adjust the proportions seen in inpatient studies. keywords: age; children; deaths; diarrhea; estimates; pathogens; rotavirus; studies; study; years cache: cord-255351-vp19ydce.txt plain text: cord-255351-vp19ydce.txt item: #254 of 672 id: cord-255384-tljyx6ua author: Decaro, Nicola title: Full-Genome Analysis of a Canine Pneumovirus Causing Acute Respiratory Disease in Dogs, Italy date: 2014-01-06 words: 4647 flesch: 51 summary: The relatedness to other CnPnVs (98.5% of aa identity) was confirmed in the putative N protein (393 aa), which displayed 6 substitutions among canine viruses. In both proteins that were 176 and 98 aa in length, respectively, the Italian CnPnV was more closely related to extant canine viruses than to MPVs (aa identities of 98.9% and 99% in the M2-1 and M2-2 products, respectively). keywords: bari/100; canine; cnpnv; dogs; gene; identity; mpv; pcr; strain; virus cache: cord-255384-tljyx6ua.txt plain text: cord-255384-tljyx6ua.txt item: #255 of 672 id: cord-255576-738khdwv author: Van Duyne, Rachel title: Localization and Sub-Cellular Shuttling of HTLV-1 Tax with the miRNA Machinery date: 2012-07-10 words: 9857 flesch: 50 summary: Interestingly, in Tax expressing cells, Drosha is almost exclusively found in the nucleus at specific foci colocalizing with Tax ( Figures 2B, C) . Here we question whether the remaining Drosha is functional in Tax expressing cells. keywords: binding; cells; control; drosha; expression; htlv-1; human; infected; infection; levels; mirna; pathway; protein; rna; tax; virus cache: cord-255576-738khdwv.txt plain text: cord-255576-738khdwv.txt item: #256 of 672 id: cord-255588-nh34lgdh author: Guo, Fang title: RO 90-7501 Enhances TLR3 and RLR Agonist Induced Antiviral Response date: 2012-10-03 words: 4799 flesch: 33 summary: The cell colonies demonstrating the highest levels of poly I:C-inducible luciferase expression (measured with Steady-Glo reagent, Promega) were expanded into cell lines and designated as 293TLR3/IFNbLuc or 293TLR3/ NFkBLuc, respectively. RO 90-7501 modulates TLR3 signal transduction, but has no effect on cells that TLR3 signal transduction is not activated The differential regulation of RO 90-7501 on the activation of IFN-b promoter and NFkB induced by poly I:C suggests that the compound modulates TLR3 signal transduction, but does not target ligand RNA or TLR3 itself. keywords: activation; cells; expression; ifn; promoter; response; tlr3; virus cache: cord-255588-nh34lgdh.txt plain text: cord-255588-nh34lgdh.txt item: #257 of 672 id: cord-256326-3ebcuzd6 author: Liotta, Giuseppe title: Is social connectedness a risk factor for the spreading of COVID-19 among older adults? The Italian paradox date: 2020-05-21 words: 2364 flesch: 51 summary: The association of social connectedness with the spread of COVID-19 among older Italian adults, hence older adult mortality rate, is not confirmed. key: cord-256326-3ebcuzd6 authors: Liotta, Giuseppe; Marazzi, Maria Cristina; Orlando, Stefano; Palombi, Leonardo title: Is social connectedness a risk factor for the spreading of COVID-19 among older adults? keywords: cases; covid-19; italy; population; years cache: cord-256326-3ebcuzd6.txt plain text: cord-256326-3ebcuzd6.txt item: #258 of 672 id: cord-256424-t3dtabi4 author: Bousbia, Sabri title: Repertoire of Intensive Care Unit Pneumonia Microbiota date: 2012-02-28 words: 5650 flesch: 34 summary: Some pathogens considered to be typical for ICU pneumonia such as Pseudomonas aeruginosa and Streptococcus species can be detected as commonly in controls as in pneumonia patients which strikingly highlights the existence of a core pulmonary microbiota. In preliminary results, we have reported the likely frequency of Tropheryma whipplei and the occurrence of vegetable DNA in pneumonia patients [12, 13] . keywords: bacteria; bal; controls; culture; fungi; icu; patients; phylotypes; pneumonia; species; studies; study; viruses cache: cord-256424-t3dtabi4.txt plain text: cord-256424-t3dtabi4.txt item: #259 of 672 id: cord-256837-100ir651 author: Smith, Steven B. title: Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis date: 2012-03-14 words: 8455 flesch: 33 summary: In particular, resistance to different classes of antiviral drugs is becoming more clinically prevalent in respiratory virus infections as seen with RSV and FLU treated with the antiviral drugs palivizumab [7] , and oseltamivir Therefore, more study is needed specifically on the role of caspase and tubulin in host response to respiratory virus infection. keywords: analysis; cells; comparison; datasets; drug; expression; factor; figure; gene; group; host; human; infection; parkin; pathways; protein; response; signaling; table; treatment; viruses cache: cord-256837-100ir651.txt plain text: cord-256837-100ir651.txt item: #260 of 672 id: cord-257077-cdnkk6ou author: Gabor, Kristin A. title: Super Resolution Microscopy Reveals that Caveolin-1 Is Required for Spatial Organization of CRFB1 and Subsequent Antiviral Signaling in Zebrafish date: 2013-07-09 words: 8662 flesch: 42 summary: To compare the effect of Cav-1b depletion on the antiviral response to pathogen, we examined control MO cells, Cav-1b MO cells, and control cells after SHRV infection in an ISRE promoterdriven luciferase assay. A greater reduction in ISRE activity was observed in either SHRV-infected or Cav-1b MO cells when compared to control MO infected cells, a finding that is consistent with the decrease in Stat1 gene expression shown in Figure 3a . keywords: cav-1b; caveolae; cells; control; crfb1; domains; expression; figure; ifn; infection; membrane; molecules; receptor; response; shrv; signaling; virus; zebrafish cache: cord-257077-cdnkk6ou.txt plain text: cord-257077-cdnkk6ou.txt item: #261 of 672 id: cord-257217-f9sdt7ax author: Nunes, Marta C. title: Clinical Epidemiology of Bocavirus, Rhinovirus, Two Polyomaviruses and Four Coronaviruses in HIV-Infected and HIV-Uninfected South African Children date: 2014-02-03 words: 4642 flesch: 37 summary: A role for Streptococcus pneumoniae in virusassociated pneumonia Respiratory viral and pneumococcal coinfection of the respiratory tract: implications of pneumococcal vaccination A new virus isolated from the human respiratory tract Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease A newly discovered human pneumovirus isolated from young children with respiratory tract disease Cloning of a human parvovirus by molecular screening of respiratory tract samples Identification of a new human coronavirus Clinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia Identification of a third human polyomavirus A newly reported human polyomavirus, KI virus, is present in the respiratory tract of Australian children Identification of a novel polyomavirus from patients with acute respiratory tract infections The role of rhinovirus in asthma exacerbations Rhinovirus viremia in children with respiratory infections Differing manifestations of respiratory syncytial virus-associated severe lower respiratory tract infections in human immunodeficiency virus type 1-infected and uninfected children Increased burden of respiratory viral associated severe lower respiratory tract infections in children infected with human immunodeficiency virus type-1 Respiratory viruses in HIV-infected patients with suspected respiratory opportunistic infection Contribution of common and recently described respiratory viruses to annual hospitalizations in children in South Africa Human polyomaviruses, WU and KI in HIV exposed children with acute lower respiratory tract infections in hospitals in South Africa Pneumococcal coinfection with human metapneumovirus A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection Evaluation of NucliSens easyMAG for automated nucleic acid extraction from various clinical specimens Development of the Respiratory Index of Severity in Children (RISC) score among young children with respiratory infections in South Africa Viral acute respiratory infections among infants visited in a rural hospital of southern Mozambique Accepted for publication) Clinical epidemiology of newly discovered respiratory viruses in HIV-infected and HIVuninfected South African children A preliminary study of pneumonia etiology among hospitalized children in Kenya Viral etiology of severe pneumonia among Kenyan infants and children Human coronavirus NL63 associated with lower respiratory tract symptoms in early life Epidemiology of multiple respiratory viruses in childcare attendees Human respiratory coronavirus HKU1 versus other coronavirus infections in Italian hospitalised patients Detection of four human coronaviruses in respiratory infections in children: a one-year study in Colorado Clinical assessment and improved diagnosis of bocavirus-induced wheezing in children Rationale and expectations of the Pneumonia Etiology Research for Child Health (PERCH) study The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children Prevention (2012) Severe coinfection with seasonal influenza A (H3N2) virus and Staphylococcus aureus-Maryland Furthermore, respiratory viral infections may heighten the susceptibility to developing a super-imposed bacterial infection resulting in severe pneumonia keywords: children; hiv; infections; lrti; study; viral; viruses cache: cord-257217-f9sdt7ax.txt plain text: cord-257217-f9sdt7ax.txt item: #262 of 672 id: cord-257603-ov0b8yub author: Azlan, Arina Anis title: Public knowledge, attitudes and practices towards COVID-19: A cross-sectional study in Malaysia date: 2020-05-21 words: 4686 flesch: 50 summary: Even so, correct rates of COVID-19 knowledge ranged widely indicating that while some participants had high levels of knowledge on the disease, others did not. Several studies conducted in other Asian countries have indicated high levels of COVID-19 knowledge among the general population [13] and healthcare workers keywords: attitudes; covid-19; health; knowledge; malaysia; mco; participants; practices; survey cache: cord-257603-ov0b8yub.txt plain text: cord-257603-ov0b8yub.txt item: #263 of 672 id: cord-258172-p54j4zzo author: Barker, Harlan title: Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2 date: 2020-10-28 words: 8473 flesch: 43 summary: In lung, ACE2 expressing cells are generally uncommon with no cell type having a ratio of ACE2-expressing cells greater than 2.6%. [27] , whereas Sims and colleagues demonstrated ACE2 expression on the luminal surface of ciliated cells in freshly excised human nasal and tracheobronchial tissue keywords: ace2; analysis; angiotensin; binding; cells; cov-2; covid-19; data; expression; gene; human; lung; mrna; receptor; sars; tissues cache: cord-258172-p54j4zzo.txt plain text: cord-258172-p54j4zzo.txt item: #264 of 672 id: cord-258243-2utl2mfl author: Chen, Jeng-Wen title: Factors associated with changing indications for adenotonsillectomy: A population-based longitudinal study date: 2018-05-29 words: 4361 flesch: 41 summary: We presented the distribution of the three major categories of surgical indication (RICI, UAO, and Tumor) as the number and percentage of patients and analyzed the trends of changing surgical indications. Table 1 shows the complete list of ICD-9-CM codes (top three diagnoses) in these categories of surgical indications. keywords: age; hospital; incidence; indications; patients; pediatric; study; tonsillectomy cache: cord-258243-2utl2mfl.txt plain text: cord-258243-2utl2mfl.txt item: #265 of 672 id: cord-258366-fu9b446y author: Couto, Carla R. title: Fighting Misconceptions to Improve Compliance with Influenza Vaccination among Health Care Workers: An Educational Project date: 2012-02-06 words: 3290 flesch: 44 summary: The compliance with influenza vaccination is poor among health care workers (HCWs) due to misconceptions about safety and effectiveness of influenza vaccine. We proposed an educational prospective study to demonstrate to HCWs that influenza vaccine is safe and that other respiratory viruses (RV) are the cause of respiratory symptoms in the months following influenza vaccination. keywords: events; hcws; influenza; study; symptoms; vaccination; vaccine cache: cord-258366-fu9b446y.txt plain text: cord-258366-fu9b446y.txt item: #266 of 672 id: cord-259771-653opx0h author: Dwivedi, Varun title: Biodegradable Nanoparticle-Entrapped Vaccine Induces Cross-Protective Immune Response against a Virulent Heterologous Respiratory Viral Infection in Pigs date: 2012-12-11 words: 5905 flesch: 39 summary: Applied Chemistry and Chemical Enginnering Delivering neuroactive molecules from biodegradable microspheres for application in central nervous system disorders Intranasal M cell uptake of nanoparticles is independently influenced by targeting ligands and buffer ionic strength Swine influenza H1N1 virus induces acute inflammatory immune responses in pig lungs: a potential animal model for human H1N1 influenza virus Porcine dendritic cells generated in vitro: morphological, phenotypic and functional properties Altered pathogenesis of porcine respiratory coronavirus in pigs due to immunosuppressive effects of dexamethasone: implications for corticosteroid use in treatment of severe acute respiratory syndrome coronavirus An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema Detection and duration of porcine reproductive and respiratory syndrome virus in semen, serum, peripheral blood mononuclear cells, and tissues from Yorkshire, Hampshire, and Landrace boars Cross-protective immunity to porcine reproductive and respiratory syndrome virus by intranasal delivery of a live virus vaccine with a potent adjuvant Induction of protective immune responses against Venezuelan equine encephalitis (VEE) virus aerosol challenge with microencapsulated VEE virus vaccine Immunogenicity of bovine parainfluenza type 3 virus proteins encapsulated in nanoparticle vaccines, following intranasal administration to mice Interferon-alpha response to swine arterivirus (PoAV), the porcine reproductive and respiratory syndrome virus Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo Biodegradable polymer microspheres as vaccine adjuvants and delivery systems Differential effects of agarose and poly(lactic-coglycolic acid) on dendritic cell maturation Differential levels of dendritic cell maturation on different biomaterials used in combination products Cellular variables in bronchoalveolar lavage fluids (BALF) in selected healthy pigs Metal-rich ambient particles (particulate matter 2.5) cause airway inflammation in healthy subjects Studies on chitosan: In a post-challenge study, Nano-KAg vaccinated MN184 challenged pigs were clinically healthy with no fever or respiratory distress. keywords: cells; figure; immune; kag; lung; mucosal; nano; pigs; prrsv; response; study; vaccinated; vaccine; virus cache: cord-259771-653opx0h.txt plain text: cord-259771-653opx0h.txt item: #267 of 672 id: cord-260432-imslfm4l author: Marshall, Jenika D. title: THP-1 macrophage cholesterol efflux is impaired by palmitoleate through Akt activation date: 2020-05-21 words: 5868 flesch: 43 summary: key: cord-260432-imslfm4l authors: Marshall, Jenika D.; Courage, Emily R.; Elliott, Ryan F.; Fitzpatrick, Madeline N.; Kim, Anne D.; Lopez-Clavijo, Andrea F.; Woolfrey, Bronwyn A.; Ouimet, Mireille; Wakelam, Michael J. O.; Brown, Robert J. title: THP-1 macrophage cholesterol efflux is impaired by palmitoleate through Akt activation date: 2020-05-21 journal: PLoS One DOI: 10.1371/journal.pone.0233180 sha: doc_id: 260432 cord_uid: imslfm4l Lipoprotein lipase (LPL) is upregulated in atherosclerotic lesions and it may promote the progression of atherosclerosis, but the mechanisms behind this process are not completely understood. Overall, our data support a negative role for the FFA component of lipoprotein hydrolysis products generated by LPL, by impairing macrophage cholesterol efflux via Akt activation. keywords: akt; cholesterol; control; efflux; ffa; fig; lipoprotein; lpl; macrophages; mixture; palmitoleate; phosphorylation; species cache: cord-260432-imslfm4l.txt plain text: cord-260432-imslfm4l.txt item: #268 of 672 id: cord-260572-vd65ygtm author: Kim, Curi title: Comparison of Nasopharyngeal and Oropharyngeal Swabs for the Diagnosis of Eight Respiratory Viruses by Real-Time Reverse Transcription-PCR Assays date: 2011-06-30 words: 3517 flesch: 46 summary: For influenza viruses, sensitivities of NP and OP swabs differed by both type and subtype: NP swabs were more sensitive than OP swabs for influenza B virus, while OP swabs were more sensitive than NP swabs for overall influenza A and 2009 H1N1 virus; there was no significant difference between swabs for H3N2 virus or the unsubtypable influenza A viruses. Previous studies evaluating NP and OP swabs in detecting influenza viruses found NP swabs to be more sensitive than OP swabs, but these studies used combined outcomes for influenza A and B viruses and did not analyze by influenza A subtypes [6, 16, 17] . keywords: influenza; patients; specimens; swabs; virus; viruses cache: cord-260572-vd65ygtm.txt plain text: cord-260572-vd65ygtm.txt item: #269 of 672 id: cord-260647-7bjhobg7 author: Coudray-Meunier, Coralie title: A Novel High-Throughput Method for Molecular Detection of Human Pathogenic Viruses Using a Nanofluidic Real-Time PCR System date: 2016-01-29 words: 5584 flesch: 39 summary: This information is available on line on the web site of the Institut de Veille Sanitaire (IVS) at http://www. invs.sante.fr/content/download/6498/42945/version/2/file/fiche_info_patient.pdf for HAV samples and on the web site of the NRC at www.cnr-ve.org for enteric virus samples. Sensitive and quantitative detection of human enteric viruses is typically achieved through quantitative RT-PCR (RT-qPCR). keywords: array; assays; detection; dpcr; qpcr; rna; samples; time; viruses cache: cord-260647-7bjhobg7.txt plain text: cord-260647-7bjhobg7.txt item: #270 of 672 id: cord-260653-5qwtvm9x author: Chikhlikar, Priya title: DNA Encoding an HIV-1 Gag/Human Lysosome-Associated Membrane Protein-1 Chimera Elicits a Broad Cellular and Humoral Immune Response in Rhesus Macaques date: 2006-12-27 words: 6151 flesch: 45 summary: The longevity of the immunological memory of B cells and CD8 + cells is also increased in animals immunized with LAMP/chimeras. The larger fraction of CD8 + T cells expressing IFN-c (.20%) following inoculation with recombinant vaccinia virus encoding Gag, in comparison with the proportion of tetramer positive cells, is attributed to the massive in vivo expansion of Gag-activated CD8 + T cells reactive against several other Gag MHC I epitopes, besides the immunodominant H-2Kd-AMQMLKETI peptide-tetramer epitope complex. keywords: antigen; cd8; cells; dna; gag; human; lamp; macaques; responses; usa cache: cord-260653-5qwtvm9x.txt plain text: cord-260653-5qwtvm9x.txt item: #271 of 672 id: cord-260728-4w23kwzu author: Timmermans, Ans title: Human Sentinel Surveillance of Influenza and Other Respiratory Viral Pathogens in Border Areas of Western Cambodia date: 2016-03-30 words: 7426 flesch: 44 summary: Previous studies have attributed the etiology of acute viral respiratory infections in Cambodia to rhinovirus, respiratory syncytial virus (RSV), parainfluenza virus (PIV), influenza virus A and B, human metapneumovirus (HMPV), bocavirus, adenovirus, enterovirus, and coronavirus Influenza virus efficiently escapes from host antibodies through an accumulation of mutations/single amino acid changes (antigenic drift) at the antigenic sites (epitopes) in surface glycoproteins of the hemagglutinin (HA) gene, and to a lesser extent, neuraminidase (NA) genes [8] . keywords: acid; amino; antigenic; cambodia; changes; gene; influenza; isolates; pcr; samples; sequences; sites; specimens; study; table; virus cache: cord-260728-4w23kwzu.txt plain text: cord-260728-4w23kwzu.txt item: #272 of 672 id: cord-260843-c97kctjz author: Dai, Lei title: Transmissible Gastroenteritis Virus Infection Enhances SGLT1 and GLUT2 Expression to Increase Glucose Uptake date: 2016-11-16 words: 4651 flesch: 40 summary: EGFR has been reported to increased glucose uptake which is critical for the cell [10] , we found the EGFR and p-EGFR both promote glucose uptake in IPEC-J2 cells during TGEV infection. In this study, we therefore sought to evaluate the effects of TGEV infection on glucose uptake and SGLT1 and GLUT2 expression. keywords: cells; egfr; expression; glucose; glut2; infection; ipec; protein; sglt1; tgev; uptake cache: cord-260843-c97kctjz.txt plain text: cord-260843-c97kctjz.txt item: #273 of 672 id: cord-261410-kb91eagd author: Park, Ji Young title: Clinical Features and Courses of Adenovirus Pneumonia in Healthy Young Adults during an Outbreak among Korean Military Personnel date: 2017-01-23 words: 3512 flesch: 41 summary: Only 12% of HAdV pneumonia patients displayed leukocytosis, whereas febrile leukopenia (62.7%) and thrombocytopenia (41%) were commonly observed. Fever, high fever (!39.0˚C), nasal congestion, sore throat, throat clearing, headache, and pharyngeal inflammation were more common among HAdV pneumonia patients than in others. keywords: adenovirus; group; hadv; infection; military; outbreak; patients; pneumonia; training cache: cord-261410-kb91eagd.txt plain text: cord-261410-kb91eagd.txt item: #274 of 672 id: cord-261908-olcuq6tm author: Lai, Ka-Man title: Propagation of Respiratory Aerosols by the Vuvuzela date: 2011-05-23 words: 3984 flesch: 47 summary: We recommend that consideration is taken of their propensity to disseminate respiratory aerosols and that persons with respiratory infections be advised not to blow their vuvuzela in places where they risk infecting others. We hypothesised that vuvuzelas might facilitate the generation and dissemination of respiratory aerosols. keywords: aerosols; air; mean; particles; peak; shouting; vuvuzela cache: cord-261908-olcuq6tm.txt plain text: cord-261908-olcuq6tm.txt item: #275 of 672 id: cord-262345-hti1jjpn author: Eddy, Lucy H. title: The validity and reliability of observational assessment tools available to measure fundamental movement skills in school-age children: A systematic review date: 2020-08-25 words: 8738 flesch: 45 summary: A systematic review was required to document the psychometric properties of the observational assessment tools being promoted as measures of FMS to allow schools and health practitioners to make informed decisions about FMS assessment tools. The aim of the review was to evaluate the psychometric properties of observational FMS assessment tools for school-age children. keywords: assessment; children; evidence; fms; motor; movement; psychometric; reliability; results; studies; study; test; tools; validity cache: cord-262345-hti1jjpn.txt plain text: cord-262345-hti1jjpn.txt item: #276 of 672 id: cord-262748-v4xue7ha author: Xu, Yongtao title: Identification of Peptide Inhibitors of Enveloped Viruses Using Support Vector Machine date: 2015-12-04 words: 4645 flesch: 34 summary: Although the exact fusion mechanism remains elusive, it was suggested that the three classes of viral fusion proteins share a similar mechanism of membrane fusion. Although the exact fusion mechanism remains elusive and the three classes of viral fusion proteins exhibit distinct structural folds, they may share a similar mechanism of membrane fusion [3] . keywords: acid; activities; amino; fusion; inhibitors; model; peptides; protein; svm; virus cache: cord-262748-v4xue7ha.txt plain text: cord-262748-v4xue7ha.txt item: #277 of 672 id: cord-262759-ec2c25q3 author: Hsieh, Yi-Ting title: Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient Epithelial Cells Are Less Tolerant to Infection by Staphylococcus aureus date: 2013-11-04 words: 4861 flesch: 38 summary: Bacterial infection or treatment with septic plasma might induce mitochondrial dysfunction by the accumulation of reactive oxygen species (ROS) and nitric oxide radical (NO ． ) in lymphocytes or epithelial cells leading to cell apoptosis Redox imbalance may induce cell apoptosis and necrosis, thus highlighting the role of G6PD in defending against oxidative damage keywords: a549; aureus; cells; deficiency; figure; g6pd; infection; ros; treatment; vancomycin cache: cord-262759-ec2c25q3.txt plain text: cord-262759-ec2c25q3.txt item: #278 of 672 id: cord-262832-5iejckwx author: Yen, Muh-Yong title: Taipei's Use of a Multi-Channel Mass Risk Communication Program to Rapidly Reverse an Epidemic of Highly Communicable Disease date: 2009-11-23 words: 5999 flesch: 46 summary: In general, children at northeastern Taipei schools, located closest to Keelung, were at greater risk for pink eye (OR = 2.26, p-value = 0.003) both at home (OR = 3.93, p-value ,0.001) and at school (OR = 2.46, p-value = 0.001), than those at schools located in districts further away (Figure 1 ). Taipei experienced a rapid decrease in AHC cases between the Friday of the SMS announcement and the following Monday, October 15, (0.70% vs. 0.36%). keywords: ahc; cases; city; communication; epidemic; health; keelung; outbreak; public; risk; school; taipei cache: cord-262832-5iejckwx.txt plain text: cord-262832-5iejckwx.txt item: #279 of 672 id: cord-262846-1mhimfsf author: Gray, Nicholas title: Is “no test is better than a bad test”? Impact of diagnostic uncertainty in mass testing on the spread of COVID-19 date: 2020-10-21 words: 6025 flesch: 51 summary: To illustrate the sensitivity of the model to testing scenarios an evaluation was conducted with a range of infection test sensitivities, from 50% (i.e of no diagnostic value) to 98%. Each test has unique parameters, so for example test A (active virus infection test) has a targeting parameter T A whilst test B (antibody test) has T B . keywords: covid-19; disease; lockdown; model; people; population; positive; sensitivity; test; testing cache: cord-262846-1mhimfsf.txt plain text: cord-262846-1mhimfsf.txt item: #280 of 672 id: cord-262876-civfvk45 author: Su, Tong title: Knowledge Levels and Training Needs of Disaster Medicine among Health Professionals, Medical Students, and Local Residents in Shanghai, China date: 2013-06-24 words: 4498 flesch: 40 summary: The selected key and interested contents on disaster medicine training were similar between health professionals and medical students, while the priorities chosen by local residents were quite different from health professionals and medical students (p<0.001). Disaster medicine training, an integrated part of efficient disaster preparedness, is vital for community residents to perform timely self-rescue and mutual-aid and also for health professionals to develop comprehensive skills [8] . keywords: community; disaster; health; medical; medicine; professionals; residents; students; training cache: cord-262876-civfvk45.txt plain text: cord-262876-civfvk45.txt item: #281 of 672 id: cord-263276-keyu60in author: Zhou, Weimin title: Prevalence of Herpes and Respiratory Viruses in Induced Sputum among Hospitalized Children with Non Typical Bacterial Community-Acquired Pneumonia date: 2013-11-18 words: 3815 flesch: 48 summary: Global burden of disease in 2002: data sources, methods and results Community-acquired pneumonia in children Etiology of community-acquired pneumonia in 254 hospitalized children Etiology of community-acquired pneumonia in hospitalized children based on WHO clinical guidelines Access to a polymerase chain reaction assay method targeting 13 respiratory viruses can reduce antibiotics: a randomised, controlled trial Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children The role of respiratory viral infections among children hospitalized for community-acquired pneumonia in a developing country Comprehensive detection of causative pathogens using real-time PCR to diagnose pediatric community-acquired pneumonia Etiology and epidemiology of viral pneumonia among hospitalized children in rural Mozambique: a malaria endemic area with high prevalence of human immunodeficiency virus Viral etiology of severe pneumonia among Kenyan infants and children Etiology of community-acquired pneumonia in hospitalized school-age children: evidence for high prevalence of viral infections Improved diagnosis of the etiology of community-acquired pneumonia with real-time polymerase chain reaction Induced sputum in the diagnosis of childhood community-acquired pneumonia Viruses and bacteria in sputum samples of children with community-acquired pneumonia Lower respiratory infections among hospitalized children in New Caledonia: a pilot study for the Pneumonia Etiology Research for Child Health project The burden of respiratory syncytial virus infection in young children Rhinovirus transmission within families with children: incidence of symptomatic and asymptomatic infections Combined cytomegalovirus prophylaxis in lung transplantation: effects on acute rejection, lymphocytic bronchitis/bronchiolitis, and herpesvirus infections Cytomegalovirus infection in critically ill patients: associated factors and consequences Herpesviruses detection by quantitative real-time polymerase chain reaction in bronchoalveolar lavage and transbronchial biopsy in lung transplant: viral infections and histopathological correlation Three new human herpesviruses (HHV6, 7, and 8) Human bocavirus infections in hospitalized children and adults Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand Update on rhinovirus and coronavirus infections Rapid and simultaneous detection of 6 types of human herpes virus (herpes simplex virus, varicella-zoster virus, Epstein-Barr virus, cytomegalovirus, human herpes virus 6A/B, and human herpes virus 7) by multiplex PCR assay Etiology and clinical characterization of respiratory virus infections in adult patients attending an emergency department in Beijing Molecular assays for detection of human metapneumovirus Epidemiological profile and clinical associations of human bocavirus and other human parvoviruses Characterization of human coronavirus etiology in Chinese adults with acute upper respiratory tract infection by real-time RT-PCR assays The role of viruses in the aetiology of community-acquired pneumonia in adults Lower respiratory tract viral infections in hospitalized adult patients Molecular monitoring of causative viruses in child acute respiratory infection in endemoepidemic situations in Shanghai Effects of coronavirus infections in children Mixed respiratory virus infections Multipathogen infections in hospitalized children with acute respiratory infections Viruses in community-acquired pneumonia in children aged less than 3 years old: high rate of viral coinfection Severe respiratory syncytial virus pneumonia associated with primary Epstein-Barr virus infection Cytomegalovirus and herpes simplex virus effect on the prognosis of mechanically ventilated patients suspected to have ventilator-associated pneumonia Cytomegalovirus pneumonia in immunocompetent host: case report and literature review CMV in critically ill patients: pathogen or bystander We thank the medical and technical staffs from the Wenling Hospital for their assistance and support. In this study, it was unable to determine whether the HHVs were reactivated from a latent reservoir after another respiratory virus infection, or if an immunosuppressed condition caused by HHV infection increases the potential risk of other respiratory virus infections. keywords: cap; children; non; pneumonia; samples; study; viruses cache: cord-263276-keyu60in.txt plain text: cord-263276-keyu60in.txt item: #282 of 672 id: cord-263453-7v4y02j6 author: Nishiura, Hiroshi title: Early Epidemiological Assessment of the Virulence of Emerging Infectious Diseases: A Case Study of an Influenza Pandemic date: 2009-08-31 words: 5352 flesch: 48 summary: doi:10.1371/journal.pone.0006852.g003 Figure 6 shows the time course of biased cCFR estimates in the USA and Canada based on the reporting date of confirmed cases and deaths to the World Health Organization. We first examine the approach by analyzing an outbreak of severe acute respiratory syndrome in Hong Kong (2003) with known unbiased cCFR estimate, and then investigate published epidemiological datasets of novel swine-origin influenza A (H1N1) virus infection in the USA and Canada (2009). keywords: cases; ccfr; deaths; estimate; onset; time cache: cord-263453-7v4y02j6.txt plain text: cord-263453-7v4y02j6.txt item: #283 of 672 id: cord-263464-fdosch11 author: Nuvey, Francis Sena title: Evaluation of the sentinel surveillance system for influenza-like illnesses in the Greater Accra region, Ghana, 2018 date: 2019-03-14 words: 4095 flesch: 44 summary: Even though the WHO's standards for influenza surveillance alluded to the possibility of resource limitation hindering achievement of all influenza surveillance system objectives, it advocates for influenza surveillance systems capable of collecting the minimum amount of data needed for decision making [5] . Morb Mortal Wkly Rep Strategy to enhance influenza surveillance worldwide A summary of influenza surveillance systems in Australia Influenza surveillance in Europe: establishing epidemic thresholds by the Moving Epidemic Method Establishing seasonal and alert influenza thresholds in Cambodia using the WHO method: implications for effective utilization of influenza surveillance in the tropics and subtropics Exploring a proposed WHO method to determine thresholds for seasonal influenza surveillance World Health Organization. keywords: case; ghana; health; ili; influenza; sentinel; sites; surveillance; system cache: cord-263464-fdosch11.txt plain text: cord-263464-fdosch11.txt item: #284 of 672 id: cord-263684-3535k3op author: Tang, Julian W. title: Different Types of Door-Opening Motions as Contributing Factors to Containment Failures in Hospital Isolation Rooms date: 2013-06-24 words: 5296 flesch: 45 summary: Yet, at least one analytical case report has demonstrated that containment failure may result from simply opening isolation room doors [23] . Brief descriptions of each door-opening scenario are also included in Tables 1 and 2 . From a qualitative visual inspection of these images, it can be clearly seen that the single-doors produce less disturbance than the double-doors, and sliding doors produce far less air exchange than hinged-doors, i.e. single-sliding,double-sliding,single-hinged,double-hinged, when the doors are graded in terms of the potential for their door-opening motion to induce bulk air flow movement across the doorways. keywords: air; door; dye; figure; food; isolation; movement; opening; room; sliding; water cache: cord-263684-3535k3op.txt plain text: cord-263684-3535k3op.txt item: #285 of 672 id: cord-263978-jk82bk1a author: Karaivanov, Alexander title: A social network model of COVID-19 date: 2020-10-29 words: 11408 flesch: 50 summary: Shorter or less strict policies can be effective at lower initial infection rates. The middle panel of Fig 13 displays simulations exploring lower initial infection rates I 0 keywords: agents; contacts; epidemic; fig; graph; infection; model; network; node; nsir; number; rate; time cache: cord-263978-jk82bk1a.txt plain text: cord-263978-jk82bk1a.txt item: #286 of 672 id: cord-264880-0tmd9knh author: Li, Zhao title: Picoliter Well Array Chip-Based Digital Recombinase Polymerase Amplification for Absolute Quantification of Nucleic Acids date: 2016-04-13 words: 5361 flesch: 42 summary: The blade was held at a 40-60°angle relative to the chip carrier so that the edge of silica gel was placed at the end of PWA chip. Silanization of the PWA chip to avoid cross-contamination The manufactured finished PWA chip was 20.8 mm × 16 mm, with 27,000 closely packed microwells. keywords: amplification; chip; detection; digital; dna; drpa; fig; isothermal; pcr; pwa; reaction; rpa; time cache: cord-264880-0tmd9knh.txt plain text: cord-264880-0tmd9knh.txt item: #287 of 672 id: cord-265138-i5m3ax7g author: Wang, Xi-Ling title: Model Selection in Time Series Studies of Influenza-Associated Mortality date: 2012-06-20 words: 4197 flesch: 38 summary: These findings shall help standardize the Poisson modeling approach for influenza disease burden studies. The burden of influenza in East and South-East Asia: a review of the English language literature The Underrecognized Burden of Influenza in Young Children The annual impact of seasonal influenza in the US: Measuring disease burden and costs Estimating influenza-associated deaths in the United States Department of Health, The Government of the Hong Kong Special Administrative Region (2012) Death statistics -by sex and age, cause of death in tabulation list of the international classification of diseases A Practical Guide for Designing and Conducting Influenza Disease Burden Studies Influenza-attributable mortality in Australians aged more than 50 years: a comparison of different modelling approaches Circulating influenza virus, climatic factors, and acute myocardial infarction: a time series study in England and Wales and Hong Kong Excess mortality monitoring in England and Wales during the influenza A(H1N1) 2009 pandemic Air pollutants and health outcomes: Assessment of confounding by influenza Confounding by Season in Ecologic Studies of Seasonal Exposures and Outcomes: Examples From Estimates of Mortality Due to Influenza Estimates of US influenza-associated deaths made using four different methods Influenza-Associated Hospitalization in a Subtropical City Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States Influenza-Associated Mortality in Hong Kong Seasonal effects of influenza on mortality in a subtropical city Validation of Statistical Models for Estimating Hospitalization Associated with Influenza and Other Respiratory Viruses Regression Models for Count Data in R Winter viruses: influenza-and respiratory syncytial virus-related morbidity in chronic lung disease Influenza and the rates of hospitalization for respiratory disease among infants and young children Part 4. keywords: criteria; data; influenza; model; mortality; poisson; study cache: cord-265138-i5m3ax7g.txt plain text: cord-265138-i5m3ax7g.txt item: #288 of 672 id: cord-265812-1hcp36cw author: De Jong, Cornelis N. title: Etanercept for steroid-refractory acute graft-versus-host disease: A single center experience date: 2017-10-26 words: 3168 flesch: 49 summary: Patients with grade II aGVHD at diagnosis are significantly more likely to achieve a CR to initial treatment with high dose steroids as compared to patients with more advanced aGVHD Treatment response rate was 28% in etanercept treated patients. keywords: agvhd; days; etanercept; line; patients; treatment cache: cord-265812-1hcp36cw.txt plain text: cord-265812-1hcp36cw.txt item: #289 of 672 id: cord-266797-uglsx7se author: Anastassopoulou, Cleo title: Data-based analysis, modelling and forecasting of the COVID-19 outbreak date: 2020-03-31 words: 5431 flesch: 48 summary: Thus, in a second scenario, we have also derived results by taking twenty times the number of reported cases for the infectious and forty times the number for the recovered cases, while keeping constant the number of deaths that is more likely to be closer to the real number. We also provide estimations of the case fatality (ĝ) and case recovery (b) ratios over the entire period using a rolling window of one day from the 11th of January to the 16th of January to provide the very first estimations. keywords: cases; data; february; january; number; recovery cache: cord-266797-uglsx7se.txt plain text: cord-266797-uglsx7se.txt item: #290 of 672 id: cord-266799-t7lqlv41 author: Rotejanaprasert, Chawarat title: Preliminary estimation of temporal and spatiotemporal dynamic measures of COVID-19 transmission in Thailand date: 2020-09-24 words: 5039 flesch: 40 summary: To approximate the disease dynamics at this early phase we adopted statistical methods to estimate disease transmission measures under various assumptions. Introduction Two critical pieces of information when a new emerging infectious disease epidemic occurs are the mechanism of disease transmission and how infectious it is. keywords: cases; control; covid-19; data; disease; number; reproduction; thailand; time; transmission cache: cord-266799-t7lqlv41.txt plain text: cord-266799-t7lqlv41.txt item: #291 of 672 id: cord-267042-nvwnbp2j author: Gaspard, Philippe title: Gastroenteritis and respiratory infection outbreaks in French nursing homes from 2007 to 2018: Morbidity and all-cause lethality according to the individual characteristics of residents date: 2019-09-24 words: 5641 flesch: 44 summary: Reported infection rates were close to 30.0% in influenza outbreaks and 40.0% in NoV outbreaks [18] [19] key: cord-267042-nvwnbp2j authors: Gaspard, Philippe; Mosnier, Anne; Simon, Loic; Ali-Brandmeyer, Olivia; Rabaud, Christian; Larocca, Sabrina; Heck, Béatrice; Aho-Glélé, Serge; Pothier, Pierre; Ambert-Balay, Katia title: Gastroenteritis and respiratory infection outbreaks in French nursing homes from 2007 to 2018: Morbidity and all-cause lethality according to the individual characteristics of residents date: 2019-09-24 journal: PLoS One DOI: 10.1371/journal.pone.0222321 sha: doc_id: 267042 cord_uid: nvwnbp2j BACKGROUND: Gastroenteritis (GE) and respiratory tract infection (RTI) outbreaks are a significant issue in nursing homes. keywords: age; autonomy; flu+; infection; influenza; lethality; los; nursing; outbreaks; residents; rti cache: cord-267042-nvwnbp2j.txt plain text: cord-267042-nvwnbp2j.txt item: #292 of 672 id: cord-267189-xq70rn1j author: Wang, Xinyu title: Co-Circulation of Canine Coronavirus I and IIa/b with High Prevalence and Genetic Diversity in Heilongjiang Province, Northeast China date: 2016-01-15 words: 3049 flesch: 48 summary: For the phylogenetic analysis, partial sequences of the M and S genes of CCoV strains, including CCoV-I, CCoV-IIa, and CCoV-IIb strains, were retrieved from GenBank. Nucleotide sequences of the partial S gene of CCoV strains identified in our study were shown in Supporting Information (S2 Fig). keywords: canine; ccov; china; coronavirus; dogs; iia; samples; strains cache: cord-267189-xq70rn1j.txt plain text: cord-267189-xq70rn1j.txt item: #293 of 672 id: cord-267307-kyh0xsrp author: Kasting, Monica L. title: Public perceptions of the effectiveness of recommended non-pharmaceutical intervention behaviors to mitigate the spread of SARS-CoV-2 date: 2020-11-04 words: 4354 flesch: 48 summary: For purposes of analyses, we divided the sample using a median split, creating two groups: those who had lower perceived effectiveness of the NPI measures (score range: 1-3.99; 47.3% of the sample) and those who had higher perceived effectiveness (score range: 4.00-5.00; 52.7% of the sample). However, little is known about public perceptions of the effectiveness of these measures, and high perceived effectiveness is likely to be critical in order to achieve widespread adoption of NPI. METHODS: keywords: cov-2; covid-19; effectiveness; health; participants; public; sars cache: cord-267307-kyh0xsrp.txt plain text: cord-267307-kyh0xsrp.txt item: #294 of 672 id: cord-267519-a0bcmjkn author: Bravi, Francesca title: Predictors of severe or lethal COVID-19, including Angiotensin Converting Enzyme inhibitors and Angiotensin II Receptor Blockers, in a sample of infected Italian citizens date: 2020-06-24 words: 3307 flesch: 34 summary: In conclusions, the present study did not find any association between COVID-19 severity and treatment with ARBs, ACE inhibitors, or both, and confirms previous findings in supporting the recommendation of several scientific societies to continue ARBs or ACE inhibitors medication for all patients, unless otherwise advised by their physicians, who should thus be reassured. Significant predictors of severe disease were older age (with AORs largely increasing after 70 years of age), male gender (AOR: 1.76; 1.40–2.23), diabetes (AOR: 1.52; 1.05–2.18), CVD (AOR: 1.88; 1.32–2.70) and COPD (AOR: 1.88; 1.11–3.20). keywords: ace; angiotensin; arbs; covid-19; disease; inhibitors; subjects cache: cord-267519-a0bcmjkn.txt plain text: cord-267519-a0bcmjkn.txt item: #295 of 672 id: cord-267566-gdjl0qmu author: Kweon, Oh Joo title: Antibody kinetics and serologic profiles of SARS-CoV-2 infection using two serologic assays date: 2020-10-22 words: 3604 flesch: 46 summary: Rigorous verification study with serially collected serum from COVID-19 patients is required to ensure analytic performance and clinical accuracy. In addition, both assays showed 94.2~96.4% of IgG specificities and increased IgG titers in COVID-19 patients were maintained. keywords: assays; cov-2; covid-19; igg; igm; patients; pso; sars cache: cord-267566-gdjl0qmu.txt plain text: cord-267566-gdjl0qmu.txt item: #296 of 672 id: cord-267605-efb10j3u author: Zheng, Li-Zhen title: Steroid-Associated Hip Joint Collapse in Bipedal Emus date: 2013-10-21 words: 5859 flesch: 40 summary: Lovastatin prevents steroid induced adipogenesis and osteonecrosis A new animal model of femoral head osteonecrosis: one that progresses to human-like mechanical failure The apparent critical isotherm for cryoinsult-induced osteonecrotic lesions in emu femoral heads Focal cryogen insults for inducing segmental osteonecrosis: computational and experimental assessments of thermal fields Emu Model of Full-range Femoral Head Osteonecrosis Induced Focally by an Alternating Freezing and Heating Insult Osteonecrosis induced by a single administration of low-dose lipopolysaccharide in rabbits Effects of pulse methylprednisolone on bone and marrow tissues: corticosteroid-induced osteonecrosis in rabbits Rapid destruction of the femoral head after a single intraarticular injection of corticosteroid into the hip joint Functional perfusion MRI predicts later occurrence of steroid-associated osteonecrosis: an experimental study in rabbits Guide for the Care and Used of Laboratory Animals Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research Impaired bone healing in rabbits with steroid-induced osteonecrosis Promotion of bone repair by implantation of cryopreserved bone marrow-derived mononuclear cells in a rabbit model of steroid-associated osteonecrosis Constitutional flavonoids derived from Epimedium dose-dependently reduce incidence of steroid-associated osteonecrosis not via direct action by themselves on potential cellular targets The effects of glucosamine hydrochloride on subchondral bone changes in an animal model of osteoarthritis Bone histomorphometry: standardization of nomenclature, symbols, and units. Focal cryogenic (liquid nitrogen) insults [23, 25] and alternative cooling and heating insults [26] have also been tested to induce ON in emus with femoral head collapse. keywords: bone; collapse; emus; figure; group; head; hip; induction; joint; model; osteonecrosis; region; saon; study cache: cord-267605-efb10j3u.txt plain text: cord-267605-efb10j3u.txt item: #297 of 672 id: cord-267644-guzn0peq author: Livadiotis, George title: Statistical analysis of the impact of environmental temperature on the exponential growth rate of cases infected by COVID-19 date: 2020-05-29 words: 6527 flesch: 46 summary: The results clearly support the first reported statistically significant relationship of negative correlation between the average environmental temperature and exponential growth rates of the infected cases. Therefore, exponential growth rate must be related to outdoors (rather than indoors) activities, and thus to the environmental temperature. keywords: cases; exponential; ffi ffi; growth; growth rate; rate; temperature cache: cord-267644-guzn0peq.txt plain text: cord-267644-guzn0peq.txt item: #298 of 672 id: cord-267973-uvz7kavu author: Do, Lien Anh Ha title: Respiratory Syncytial Virus and Other Viral Infections among Children under Two Years Old in Southern Vietnam 2009-2010: Clinical Characteristics and Disease Severity date: 2016-08-08 words: 5924 flesch: 45 summary: RSV infections occurred at younger age than three other leading viral infections i.e rhinovirus (RV), metapneumovirus (MPV), parainfluenza virus (PIV-3) and were significantly more frequent in the first 6 months of life. Clinical severity score of RSV infection was significantly higher than PIV-3 but not for RV or MPV. keywords: cases; children; disease; infections; load; n(%; rsv; severity; study; virus cache: cord-267973-uvz7kavu.txt plain text: cord-267973-uvz7kavu.txt item: #299 of 672 id: cord-268429-drejl99k author: Almberg, Emily S. title: A Serological Survey of Infectious Disease in Yellowstone National Park’s Canid Community date: 2009-09-16 words: 7281 flesch: 46 summary: The probability of CDV exposure among wolf pups was highest in 1999, 2002, and 2005, a pattern less clearly mirrored in the adult data (no year effect was significant) (Figure 1 , Table S3 ). Both juvenile and adult coyote seroprevalence mirrored the temporal patterns among NR wolf pups; CDV seroprevalence was 100% in 1999 and 2005 among both age groups and 0% otherwise among juveniles (year effects were not significant; Figure 1 ). keywords: canine; caninum; cdv; coyotes; exposure; interior; pup; survival; wolf; wolves; ynp cache: cord-268429-drejl99k.txt plain text: cord-268429-drejl99k.txt item: #300 of 672 id: cord-268524-lr51ubz5 author: Droit-Volet, Sylvie title: Time and Covid-19 stress in the lockdown situation: Time free, «Dying» of boredom and sadness date: 2020-08-10 words: 5272 flesch: 49 summary: A social-psychological investigation into the process of time orientation Mindfulness meditation, time judgment and time experience: Importance of the time scale considered (seconds or minutes) Awareness of the passage of time and self-consciousness: What do meditators report? Nonetheless, in the different distress scales used, the different dimensions of emotion (valence and arousal) were not dissociated, and no survey has examined their relationships to time experience, even though emotion and the experience of time are known to be intrinsically linked. keywords: boredom; covid-19; experience; lockdown; passage; stress; time cache: cord-268524-lr51ubz5.txt plain text: cord-268524-lr51ubz5.txt item: #301 of 672 id: cord-268816-nth3o6ot author: Roy, Satyaki title: Factors affecting COVID-19 infected and death rates inform lockdown-related policymaking date: 2020-10-23 words: 5736 flesch: 50 summary: • Distance from one state to another (is not measured in miles but the euclidean distance between their latitude-longitude coordinates between the pair of states [32] ) (filename: source/Data_distance.xlsx, feature name: d(state1, state2)). • Gender feature(s) is a fraction of total population representing the male and female individuals [33] (filename: source/Data_gender.csv, feature name: Male, Female). keywords: age; airport; covid-19; death; factors; feature; infection; lockdown; population; pre; states; testing cache: cord-268816-nth3o6ot.txt plain text: cord-268816-nth3o6ot.txt item: #302 of 672 id: cord-268977-hcg2rrhl author: Feikin, Daniel R. title: Etiology and Incidence of Viral and Bacterial Acute Respiratory Illness among Older Children and Adults in Rural Western Kenya, 2007–2010 date: 2012-08-24 words: 6449 flesch: 43 summary: The percentage of malaria blood smears positive among ARI patients ranged from (13) 1041 (10) 341 (8) 3406 (11) -1194 (62) 2212 (8) 489 (14) 802 (7) CFR a for ARI cases (5) 15 (4) 73 (2) -69 For ARI patients, blood, nasopharyngeal and oropharyngeal specimens using polyester-tipped swabs, and urine were collected. keywords: adults; ari; cases; controls; hiv; incidence; influenza; pathogen; patients; pneumonia; study; virus; years cache: cord-268977-hcg2rrhl.txt plain text: cord-268977-hcg2rrhl.txt item: #303 of 672 id: cord-269453-30l6rzgo author: Yang, Po title: Feasibility study of mitigation and suppression strategies for controlling COVID-19 outbreaks in London and Wuhan date: 2020-08-06 words: 6785 flesch: 49 summary: Suppression intervention from the 32 nd day: the peak of daily infections greatly reduced to 16 thousand, but it had to be followed at least 200 days. We used a benchmark reported in [11] that assumes Hubei province with no intervention as M = 15, and after suppression intervention, M reduced to 3. keywords: cases; covid-19; intervention; london; model; number; population; suppression; wuhan cache: cord-269453-30l6rzgo.txt plain text: cord-269453-30l6rzgo.txt item: #304 of 672 id: cord-269690-6r2bfydw author: De Lorenzo, Rebecca title: Residual clinical damage after COVID-19: A retrospective and prospective observational cohort study date: 2020-10-14 words: 4423 flesch: 40 summary: This is consistent with the hypothesis that SARS-CoV-2 infection may be associated with chronic cardiovascular damage [30] , and highlights the need of cardiovascular care in the management of COVID-19 patients. Among hospitalised patients, age ≥63 years, or age <63 plus non-invasive ventilation or diabetes identified those with the highest probability to need follow-up. keywords: age; analysis; covid-19; disease; follow; malnutrition; need; patients; ptsd cache: cord-269690-6r2bfydw.txt plain text: cord-269690-6r2bfydw.txt item: #305 of 672 id: cord-270408-4qqyb8sd author: Pane, Masdalina title: Causes of Mortality for Indonesian Hajj Pilgrims: Comparison between Routine Death Certificate and Verbal Autopsy Findings date: 2013-08-21 words: 3459 flesch: 49 summary: key: cord-270408-4qqyb8sd authors: Pane, Masdalina; Imari, Sholah; Alwi, Qomariah; Nyoman Kandun, I; Cook, Alex R.; Samaan, Gina title: Causes of Mortality for Indonesian Hajj Pilgrims: Comparison between Routine Death Certificate and Verbal Autopsy Findings date: 2013-08-21 journal: PLoS One DOI: 10.1371/journal.pone.0073243 sha: doc_id: 270408 cord_uid: 4qqyb8sd BACKGROUND: Indonesia provides the largest single source of pilgrims for the Hajj (10%). Pattern of diseases among visitors to Mina health centers during the Hajj season, 1429 H (2008 G) Hajj: health lessons for mass gatherings Common health hazards in French pilgrims during the Hajj of 2007: a prospective cohort study The epidemiology of Hajj-related critical illness: lessons for deployment of temporary critical care services* Comparison of mortality and morbidity rates among Iranian pilgrims in Hajj How to reduce cardiovascular mortality and morbidity among Hajj Pilgrims: A multiphasic screening, intervention and assessment Verbal autopsy: current practices and challenges Potential and limits of verbal autopsies Factors associated with place of death in Addis Ababa Applying verbal autopsy to determine cause of death in rural Vietnam Accuracy of WHO Verbal Autopsy Tool in Determining Major Causes of Neonatal Deaths in India Verbal Autopsy Standards: Ascertaining and attributing causes of death Famine-affected, refugee, and displaced populations: recommendations for public health issues Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies Causes of admission to intensive care units in the Hajj period of the Islamic year 1424 Clinical and temporal patterns of severe pneumonia causing critical illness during Hajj A review of data-derived methods for assigning causes of death from verbal autopsy data Physical activity and stroke in British middle aged men Influence of graded dehydration on hyperthermia and cardiovascular drift during exercise Tuberculosis is the commonest cause of pneumonia requiring hospitalization during Hajj (pilgrimage to Makkah) High risk of Mycobacterium tuberculosis infection during the Hajj pilgrimage Country profile -Indonesia Indonesian pilgrims suffer high mortality rates despite predeparture screenings, accompanying medical teams and the availability of specialized health services during the Hajj. keywords: autopsy; death; hajj; health; indonesian; mortality; pilgrims cache: cord-270408-4qqyb8sd.txt plain text: cord-270408-4qqyb8sd.txt item: #306 of 672 id: cord-270647-vn4kirrx author: Romero-Espinoza, Jose A. title: Virome and bacteriome characterization of children with pneumonia and asthma in Mexico City during winter seasons 2014 and 2015 date: 2018-02-15 words: 3518 flesch: 43 summary: Molecular detection of human rhinoviruses in respiratory samples: a comparison of Taqman probe-, SYBR green I-and BOXTObased real-time PCR assays Detection and Characterization of respiratory viruses causing Acute Respiratory Illness and Asthma Exacerbation in children during Three Different Season (2011-2014) in Mexico City. The role of respiratory viruses in the etiology of bacterial pneumonia: keywords: asthma; children; diseases; dna; et.al; pneumonia; reads; samples; tract; viruses cache: cord-270647-vn4kirrx.txt plain text: cord-270647-vn4kirrx.txt item: #307 of 672 id: cord-270681-6ayciihs author: Bálint, Ádám title: Comparative In Vivo Analysis of Recombinant Type II Feline Coronaviruses with Truncated and Completed ORF3 Region date: 2014-02-20 words: 4702 flesch: 42 summary: ABCD guidelines on prevention and management A review of feline infectious peritonitis virus infection: 1963-2008 Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses Acquisition of macrophage tropism during the pathogenesis of feline infectious peritonitis is determined by mutations in the feline coronavirus spike protein Spike protein fusion peptide and feline coronavirus virulence Deletions in the 7a ORF of feline coronavirus associated with an epidemic of feline infectious peritonitis The role of accessory proteins in the replication of feline infectious peritonitis virus in peripheral blood monocytes Feline infectious peritonitis; insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3c gene Sequence analysis of feline coronaviruses and the circulating virulent/avirulent theory Significance of coronavirus mutants in feces and diseased tissues of cats suffering from feline infectious peritonitis Molecular characterization of feline infectious peritonitis virus strain DF-2 and studies on the role of ORF3abc in viral cell tropism Live, attenuated coronavirus vaccines through the directed deletion of group-specific genes provide protection against feline infectious peritonitis Expression of CD134 and CXCR4 mRNA in term placentas from FIV-infected and control cats Differentiation of feline coronavirus type I and II infections by virus neutralization test Replication of feline coronaviruses in peripheral blood monocytes High viral loads despite absence of clinical and pathological findings in cats experimentally infected with feline coronavirus (FCoV) type I and in naturally FCoV-infected cats Pathogenic characteristics of persistent feline enteric coronavirus infection in cats Feline infectious peritonitis: role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats Challenge trial of an intranasal feline infectious peritonitis vaccine Virus-encoded proteinases and proteolytic processing in the Nidovirales SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: While parent virus FIPV DF-2 developed feline infectious peritonitis in all the infected cats, its recombinant virus PBFIPV-DF-2, differing only in seven nucleotides, proved to be surprisingly low virulent, although caused an acute febrile episode similarly to the original FIPV DF-2. keywords: cats; coronavirus; day; df-2; fcov; feline; orf3abc; p.i; pbfipv; rna; virus cache: cord-270681-6ayciihs.txt plain text: cord-270681-6ayciihs.txt item: #308 of 672 id: cord-270683-982eqtog author: Pavel, Shaikh Terkis Islam title: Isolation and characterization of severe acute respiratory syndrome coronavirus 2 in Turkey date: 2020-09-16 words: 5535 flesch: 56 summary: The diluted sample was inoculated onto monolayers of Vero E6 cells and gently agitated at 37˚C for 1 h. Consequently, DMEM with 2% FBS was added and the infected cells were monitored for the appearance of cytopathic effect (CPE). Twenty-four-well plates were seeded with Vero E6 cells and incubated at 37˚C with 5% CO 2 . keywords: cell; coronavirus; cov-2; fig; infection; lines; ma-104; sars; turkey; vero; virus cache: cord-270683-982eqtog.txt plain text: cord-270683-982eqtog.txt item: #309 of 672 id: cord-271660-5sfkhg19 author: Sun, Hsin-Yun title: Impact of introducing fluorescent microscopy on hospital tuberculosis control: A before-after study at a high caseload medical center in Taiwan date: 2020-04-03 words: 3893 flesch: 35 summary: Contact investigation had been expanded to all HCWs who were exposed to TB patients since 2004. In keeping with previous observations (S3 Table) , the absence of cough and other typical symptoms is a barrier to prompt respiratory isolation of TB patients (S2 Table) . keywords: isolation; microscopy; patients; respiratory; risk; smear; tuberculosis cache: cord-271660-5sfkhg19.txt plain text: cord-271660-5sfkhg19.txt item: #310 of 672 id: cord-272445-0xauff51 author: Naaber, Paul title: Evaluation of SARS-CoV-2 IgG antibody response in PCR positive patients: Comparison of nine tests in relation to clinical data date: 2020-10-27 words: 2752 flesch: 45 summary: Given the large variability in antibody tests, discrepancies between test results are expected. We found a remarkable variation in the sensitivity of antibody tests with the following performance: LIPS N (91.8%), Epitope (85.6%), Abbott and in-house LIPS S-RBD (both 84.5%), Roche (83.5%), Euroimmun (82.5%), DiaSorin (81.4%), SNIBE (70.1%), and Biosensor (64.9%). keywords: antibody; covid-19; patients; results; tests cache: cord-272445-0xauff51.txt plain text: cord-272445-0xauff51.txt item: #311 of 672 id: cord-272655-qeojdpez author: Remolina, Yuly Andrea title: Viral Infection in Adults with Severe Acute Respiratory Infection in Colombia date: 2015-11-17 words: 4310 flesch: 37 summary: Furthermore, current challenges in the epidemiological surveillance of viral respiratory tract infections include the early and fast identification of aetiological agents, especially at the beginnings of outbreaks, and the optimal and timely management of a large number of samples [14] . Results from a prospective, population-based study Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults Bacterial complications of respiratory tract viral illness: a comprehensive evaluation Estimates of mortality attributable to influenza and RSV in the United States during 1997-2009 by influenza type or subtype, age, cause of death, and risk status Roles of humidity and temperature in shaping influenza seasonality Epidemiology and seasonality of respiratory tract virus infections in the tropics Utilization of nucleic acid amplification assays for the detection of respiratory viruses Comparative evaluation of effectiveness of IAVchip DNA microarray in influenza A diagnosis Microorganisms in respiratory tract of patients diagnosed with atypical pneumonia: results of a research based on the use of reverse transcription polymerase chain reaction (RT-PCR) DNA microarray method and enzyme-linked immunosorbent assay The clinical utility of a near patient care rapid microarray-based diagnostic test for influenza and respiratory syncytial virus infections in the pediatric setting Multi-center evaluation of the adenovirus R-gene US assay for the detection of adenovirus in respiratory samples Antibiotic prescribing in ambulatory care settings for adults with colds, upper respiratory tract infections, and bronchitis Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections A role for Streptococcus pneumoniae in virus-associated pneumonia keywords: cases; days; hospital; infections; influenza; patients; pneumonia; study; virus cache: cord-272655-qeojdpez.txt plain text: cord-272655-qeojdpez.txt item: #312 of 672 id: cord-272878-6f0q661e author: Schnepf, Nathalie title: High Burden of Non-Influenza Viruses in Influenza-Like Illness in the Early Weeks of H1N1v Epidemic in France date: 2011-08-17 words: 4178 flesch: 40 summary: The interferon response circuit: induction and suppression by pathogenic viruses Situation épidémiologique de la bronchiolite Portrait of a year-old pandemic Detection of extensive cross-neutralization between pandemic and seasonal A/ H1N1 Influenza Viruses using a pseudotype neutralization assay Multiplex real-time PCR for detection of respiratory tract infections Frequent detection of viral coinfection in children hospitalized with acute respiratory tract infection using a real-time polymerase chain reaction Detection of multiple respiratory pathogens during primary respiratory infection: nasal swab versus nasopharyngeal aspirate using real-time polymerase chain reaction Prospective evaluation of a novel multiplex real-time PCR assay for detection of fifteen respiratory pathogens-duration of symptoms significantly affects detection rate Improving the clinical diagnosis of influenza-a comparative analysis of new influenza A (H1N1) cases Molecular diagnosis of respiratory viruses Detection of respiratory viruses by molecular methods Comprehensive diagnostics for respiratory virus infections after transplantation or after potential exposure to swine flu A/H1N1: what else is out there? Another possible explanation is better prevention behaviour about respiratory infections as recommended by a national campaign including recommendations for hands washing after sneezing and the use of mask [1] . keywords: assay; data; h1n1v; infections; influenza; pathogens; patients; positive; viruses cache: cord-272878-6f0q661e.txt plain text: cord-272878-6f0q661e.txt item: #313 of 672 id: cord-272971-9luzvzsu author: Guo, Hainan title: Hong Kong Hospital Authority resource efficiency evaluation: Via a novel DEA-Malmquist model and Tobit regression model date: 2017-09-08 words: 6012 flesch: 47 summary: The measurement of hospital efficiency might be biased if the undesirable factors are ignored. In this section, we first analyze the HKHA data, and then discuss the measurement results of hospital efficiency in HK from 2000 to 2013 by applying Malmquist index based on GSBUP-DEA. keywords: dea; efficiency; factors; gsbup; healthcare; hkha; hospital; inputs; medical; model; resource cache: cord-272971-9luzvzsu.txt plain text: cord-272971-9luzvzsu.txt item: #314 of 672 id: cord-273175-bao8xxe2 author: Tran, Viet-Thi title: COVID-19–related perceptions, context and attitudes of adults with chronic conditions: Results from a cross-sectional survey nested in the ComPaRe e-cohort date: 2020-08-06 words: 3862 flesch: 45 summary: About one quarter of patients would refuse any contact with symptomatic people (17.8% and 23.4% for occasional and COVID-19-related perceptions, context and attitudes of adults with chronic conditions frequent contacts, respectively). key: cord-273175-bao8xxe2 authors: Tran, Viet-Thi; Ravaud, Philippe title: COVID-19–related perceptions, context and attitudes of adults with chronic conditions: Results from a cross-sectional survey nested in the ComPaRe e-cohort date: 2020-08-06 journal: PLoS One DOI: 10.1371/journal.pone.0237296 sha: doc_id: 273175 cord_uid: bao8xxe2 BACKGROUND: To avoid a surge of demand on the healthcare system due to the COVID-19 pandemic, we must reduce transmission to individuals with chronic conditions who are at risk of severe illness with COVID-19. keywords: chronic; conditions; contacts; covid-19; participants; patients; people; risk cache: cord-273175-bao8xxe2.txt plain text: cord-273175-bao8xxe2.txt item: #315 of 672 id: cord-273343-als886fe author: McClenahan, Shasta D. title: Discovery of a Bovine Enterovirus in Alpaca date: 2013-08-12 words: 4603 flesch: 45 summary: Viral diseases of new world camelids Census of Agriculture Chronic weight loss in an immunodeficient adult llama Camelid immunoglobulins and their importance for the newborn-a review Evaluation of bovine viral diarrhea virus in New World camelids Bovine viral diarrhea virus in New World camelids Isolation of bovine viral diarrhea virus from an alpaca BVDV in British alpacas Genotyping and phylogenetic analysis of bovine viral diarrhea virus isolates from BVDV infected alpacas in North America Prevalence of bovine viral diarrhea virus infections in alpacas in the United States Persistent infection with bovine viral diarrhea virus in an alpaca Update on llama medicine. [1, 3, 4] and bovine viral diarrhea virus keywords: alpaca; bovine; enterovirus; min; pcr; sequences; serotypes; virus; viruses cache: cord-273343-als886fe.txt plain text: cord-273343-als886fe.txt item: #316 of 672 id: cord-273594-vmbhok1u author: Sichelstiel, Anke title: Targeting IL-1β and IL-17A Driven Inflammation during Influenza-Induced Exacerbations of Chronic Lung Inflammation date: 2014-06-11 words: 5628 flesch: 36 summary: Overall, blockade of IL-17A and IL-1b could be valuable therapeutic options for future treatment of viral induced exacerbations of chronic lung inflammation. In order to investigate the role of IL-1b during COPD exacerbations we utilized a model of LPS and elastase induced chronic lung inflammation, followed by infection with influenza in wild type or IL-1b deficient mice. keywords: chronic; disease; exacerbations; figure; il-17a; il-1b; infection; inflammation; influenza; lung; mice; pulmonary cache: cord-273594-vmbhok1u.txt plain text: cord-273594-vmbhok1u.txt item: #317 of 672 id: cord-273764-itu39mln author: Li, Taisheng title: Long-Term Persistence of Robust Antibody and Cytotoxic T Cell Responses in Recovered Patients Infected with SARS Coronavirus date: 2006-12-20 words: 2663 flesch: 44 summary: Neutralizing antibodies in patients with severe acute respiratory syndrome-associated coronavirus infection Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals Antibody response of patients with severe acute respiratory syndrome (SARS) targets the viral nucleocapsid Antibody responses against SARS-coronavirus and its nucleocaspid in SARS patients Longitudinal profile of immunoglobulin G (IgG), IgM, and IgA antibodies against the severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein in patients with pneumonia due to the SARS coronavirus Detection of specific antibodies to severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein for serodiagnosis of SARS coronavirus pneumonia Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Significant changes of peripheral T lymphocyte subsets in patients with severe acute respiratory syndrome We feel in debt to patients' willingness to participate our study. 3B summarizes results for all the samples tested and four peptide pools, namely NX4, NX6, NY6, and NY7, were found to be preferentially recognized by recovered SARS patients (Fig. 3B ). keywords: changes; fig; patients; responses; sars cache: cord-273764-itu39mln.txt plain text: cord-273764-itu39mln.txt item: #318 of 672 id: cord-274241-biqbsggu author: Shaw, Timothy I. title: Transcriptome Sequencing and Annotation for the Jamaican Fruit Bat (Artibeus jamaicensis) date: 2012-11-15 words: 6004 flesch: 48 summary: Human and mouse genomes were used as references to estimate the distribution of bat contigs within known gene transcripts. Horse and human were identified as the top two species with best BLAST hits for bat contigs ( Figure 2 ). keywords: analysis; artibeus; bats; contigs; fruit; genes; genome; human; immune; mouse; sequences; species; transcriptome; tree; virus cache: cord-274241-biqbsggu.txt plain text: cord-274241-biqbsggu.txt item: #319 of 672 id: cord-274268-0ucqp3uz author: Chorus, Caspar title: Diabolical dilemmas of COVID-19: An empirical study into Dutch society’s trade-offs between health impacts and other effects of the lockdown date: 2020-09-16 words: 7804 flesch: 40 summary: Returning to the fact that our sample, while representative in terms of gender and age, is somewhat skewed towards highly educated people (see Table 2 ), these segment-specific estimation results imply that our aggregate level estimates for society's weighing of various policy impacts of exit strategies is likely to somewhat underestimate the weight attached to fatalities and to somewhat overestimate the weight attached to other policy impacts such as physical and mental injuries, educational advantage, and income loss. With a view to exploring potential causes behind differences in weights attached to fatalities and other policy impacts, we estimated a series of two-class latent class models, where class membership was determined by respondents' perceived risk that they or a relative would contract COVID-19, would become severely ill if having contracted the virus, would be hospitalized if contracting the virus, or would die if contracting the virus. keywords: choice; class; covid-19; dutch; effects; health; impacts; model; number; policies; policy; respondents; terms cache: cord-274268-0ucqp3uz.txt plain text: cord-274268-0ucqp3uz.txt item: #320 of 672 id: cord-275058-61eof7y8 author: Inoue, Hiroyasu title: The propagation of economic impacts through supply chains: The case of a mega-city lockdown to prevent the spread of COVID-19 date: 2020-09-15 words: 3993 flesch: 50 summary: key: cord-275058-61eof7y8 authors: Inoue, Hiroyasu; Todo, Yasuyuki title: The propagation of economic impacts through supply chains: The case of a mega-city lockdown to prevent the spread of COVID-19 date: 2020-09-15 journal: PLoS One DOI: 10.1371/journal.pone.0239251 sha: doc_id: 275058 cord_uid: 61eof7y8 The negative effect of such a lockdown may propagate to other regions through supply chains because of supply and demand shortages. keywords: chains; effect; lockdown; production; supply; tokyo cache: cord-275058-61eof7y8.txt plain text: cord-275058-61eof7y8.txt item: #321 of 672 id: cord-275395-w2u7fq1g author: Romero-Severson, Ethan Obie title: Change in global transmission rates of COVID-19 through May 6 2020 date: 2020-08-06 words: 4024 flesch: 52 summary: Most countries showed large decreases in transmission rates over time, and more than half of studied countries have transmission rates below the epidemic threshold. The model is then simulated forward for 21 days, assuming exponential growth with transmission rate χ 0 , which is taken at the initial state of the model at time zero. keywords: countries; data; deaths; model; rate; time; transmission cache: cord-275395-w2u7fq1g.txt plain text: cord-275395-w2u7fq1g.txt item: #322 of 672 id: cord-276372-q1fzxt3r author: Conde, Dalia A. title: Zoos through the Lens of the IUCN Red List: A Global Metapopulation Approach to Support Conservation Breeding Programs date: 2013-12-11 words: 4781 flesch: 42 summary: Only two of the 59 taxonomic orders show a higher proportion of threatened species in ISIS zoos than would be expected if species were selected at random. To determine whether the number of threatened species in ISIS zoos is different from what would result from a random sample, we carried out the following analyses. keywords: cbps; conservation; individuals; isis; metapopulation; number; species; zoos cache: cord-276372-q1fzxt3r.txt plain text: cord-276372-q1fzxt3r.txt item: #323 of 672 id: cord-276577-06boh550 author: Schanzer, Dena L. title: Estimating Sensitivity of Laboratory Testing for Influenza in Canada through Modelling date: 2009-08-18 words: 3961 flesch: 33 summary: While the null value for b 5 is zero, which indicates no statistical association between the number of influenza positive tests and the number of influenza negative tests, the corresponding null value for sensitivity is 1. The weekly number of influenza negative tests estimated to be falsely negative is given by b 5 InflA w +b 6 InflB w . keywords: influenza; model; number; sensitivity; testing; tests; viruses cache: cord-276577-06boh550.txt plain text: cord-276577-06boh550.txt item: #324 of 672 id: cord-276763-x3dqi0ym author: Lowery-North, Douglas W. title: Measuring Social Contacts in the Emergency Department date: 2013-08-21 words: 6208 flesch: 53 summary: Therefore, number and total duration of staff contacts are underestimated. The authors found 71% of staff contact events were with other staff. keywords: contact; cross; duration; hospital; infection; number; patient; shift; staff; study; system cache: cord-276763-x3dqi0ym.txt plain text: cord-276763-x3dqi0ym.txt item: #325 of 672 id: cord-276898-ia80cy8j author: Yamanaka, Atsushi title: Imported Case of Acute Respiratory Tract Infection Associated with a Member of Species Nelson Bay Orthoreovirus date: 2014-03-25 words: 3856 flesch: 46 summary: Orthoreoviruses and their replication Piscine reovirus encodes a cytotoxic, non-fusogenic, integral membrane protein and previously unrecognized virion outer-capsid proteins A previously unknown reovirus of bat origin is associated with an acute respiratory disease in humans Identification and characterization of a new orthoreovirus from patients with acute respiratory infections Investigation of a potential zoonotic transmission of orthoreovirus associated with acute influenza-like illness in an adult patient A novel reovirus isolated from a patient with acute respiratory disease Xi River virus, a new bat reovirus isolated in southern China Pulau virus; a new member of the Nelson Bay orthoreovirus species isolated from fruit bats in Malaysia Structure and cytopathic effects of Nelson Bay virus Rapid genome sequencing of RNA viruses An improved procedure for rapid determination of viral RNA sequences of avian RNA viruses Novel reovirus isolation from an Ostrich (Struthio camelus) in Japan Bat coronaviruses and experimental infection of bats, the Philippines Ligationmediated amplification for effective rapid determination of viral RNA sequences (RDV) Novel virus discovery in field-collected mosquito larvae using an improved system for rapid determination of viral RNA sequences (RDV ver4.0) Pathogenic characteristics of highly virulent avian reovirus, strain 58-132, isolated from a chicken with tenosynovitis A post-entry step in the mammalian orthoreovirus replication cycle is a determinant of cell tropism A plasmid-based reverse genetics system for animal double-stranded RNA viruses The Great Island subgroup of tick-borne orbiviruses represents a single gene pool Virulence potential of fusogenic orthoreoviruses A novel approach for collecting samples from fruit bats for isolation of infectious agents Bats: important reservoir hosts of emerging viruses A morbillivirus that caused fatal disease in horses and humans Hendra and Nipah viruses: different and dangerous Nipah virus: a recently emergent deadly paramyxovirus An apparently new virus (family Paramyxoviridae) infectious for pigs, humans, and fruit bats Probable human infection with a newly described virus in the family Paramyxoviridae. S2-segment of Miyazaki-Bali/2007 had the highest homology with being approximately 92-94% in nucleotide sequences to those of HK23629/07, HK46886/09, and HK50842/10, which also seem to have originated in Indonesia [6, 20] , while it showed 83-90% homology to those of Kampar, Melaka, Pulau, Sikamat, and Nelson Bay viruses. keywords: bali/2007; bay; miyazaki; nelson; orthoreovirus; patient; protein; sequences; species; viruses cache: cord-276898-ia80cy8j.txt plain text: cord-276898-ia80cy8j.txt item: #326 of 672 id: cord-277306-r8jki3x4 author: Osborne, Christina title: Alphacoronaviruses in New World Bats: Prevalence, Persistence, Phylogeny, and Potential for Interaction with Humans date: 2011-05-12 words: 5192 flesch: 52 summary: Similar findings were made in rhinolophid bats in Asia that harbor SARs-like-bat-CoVs [37] and in fruit bats experimentally infected with bat CoVs which showed no signs of illness [39] . To assess the potential for zoonotic transmission of bat CoVs, we focused part of this present work on North American bats that have the closest contact with humans and sampled roosts where big brown bats had histories of contact or potential for contact with people [30] . keywords: bats; brown; colorado; cov; covs; prevalence; rna; sequences; site; species; viruses; world cache: cord-277306-r8jki3x4.txt plain text: cord-277306-r8jki3x4.txt item: #327 of 672 id: cord-277357-lpurk7pe author: González-González, Everardo title: Portable and accurate diagnostics for COVID-19: Combined use of the miniPCR thermocycler and a well-plate reader for SARS-CoV-2 virus detection date: 2020-08-13 words: 4008 flesch: 44 summary: The blueGel1 has several important advantages and represents a valid and portable solution for detecting PCR amplification products. Our results suggest that using a commercial plate reader to determine the extent of advance of PCR amplifications is a practical, reliable, reproducible, and robust alternative to the use of gel electrophoresis. keywords: amplification; cov-2; covid-19; detection; fluorescence; minipcr; plate; reader; sars cache: cord-277357-lpurk7pe.txt plain text: cord-277357-lpurk7pe.txt item: #328 of 672 id: cord-277409-q5wx313k author: Resende, Lucilene Aparecida title: Impact of LbSapSal Vaccine in Canine Immunological and Parasitological Features before and after Leishmania chagasi-Challenge date: 2016-08-24 words: 7946 flesch: 39 summary: All the analyzed dogs were euthanized 885 days after L. chagasi-experimental challenge and the spleens were collected to evaluate parasite loads. The establishment of a prominent pro-inflammatory immune response after “LbSapSal” immunization supported the increased levels of nitric oxide production, favoring a reduction in spleen parasitism (78.9%) and indicating long-lasting protection against L. chagasi infection. keywords: chagasi; challenge; control; dogs; experimental; fig; group; ifn; lbsapsal; leishmania; levels; panel; parasite; slca cache: cord-277409-q5wx313k.txt plain text: cord-277409-q5wx313k.txt item: #329 of 672 id: cord-277548-hgmmtew3 author: Lou, Emil title: Perspectives of cancer patients and their health during the COVID-19 pandemic date: 2020-10-30 words: 2841 flesch: 42 summary: The objective of this study was to compare concerns about COVID-19 among individuals undergoing cancer treatment to those with a history of cancer not currently receiving therapy and to those without a cancer history. Survey items included demographics, personal concerns about COVID-19, and among those currently receiving cancer therapy, perceived effects of the COVID-19 pandemic on cancer treatment. keywords: cancer; covid-19; history; pandemic; patients; treatment cache: cord-277548-hgmmtew3.txt plain text: cord-277548-hgmmtew3.txt item: #330 of 672 id: cord-278018-3qemb0x3 author: Li, Li title: Identification of M.tuberculosis-Specific Th1 Cells Expressing CD69 Generated in vivo in Pleural Fluid Cells from Patients with Tuberculous Pleurisy date: 2011-08-22 words: 5994 flesch: 50 summary: Previous studies have also demonstrated the usefulness of the determination of CD69 on CD4 + T cells after in vitro stimulation with tuberculin as a rapid indicator of immune sensitization against MTB We found a significant increase in CD69 expression on CD4 + T cells in PFCs. keywords: cd4; cd69; cells; expression; ifn; t cells; th1; tnf cache: cord-278018-3qemb0x3.txt plain text: cord-278018-3qemb0x3.txt item: #331 of 672 id: cord-278087-0nicp0eq author: García-García, María Luz title: Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study date: 2017-03-16 words: 3004 flesch: 45 summary: In our series, clinical differences have been found between HMPV infections and other respiratory viruses infections. According to this large and both long series, i.e. nine consecutive epidemic seasons, of respiratory infections in hospitalized children, hMPV had an important role in infants and was associated with 5.5% of admissions. keywords: children; hmpv; hrsv; infections; viruses cache: cord-278087-0nicp0eq.txt plain text: cord-278087-0nicp0eq.txt item: #332 of 672 id: cord-278099-ypov9ha3 author: Kumar, Surender title: Molecular characterization of a novel cryptic virus infecting pigeonpea plants date: 2017-08-03 words: 11418 flesch: 49 summary: Emaravirus: A novel genus of multipartite negative strand RNA plant viruses The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses Interference with viral infection by defective RNA replicase Effects of mutations in poliovirus 3Dpol on RNA polymerase activityand on polyprotein cleavage Enzymatic activity of poliovirus RNA polymerase mutants with single amino acid changes in the conserved YGDD amino acid motif Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity Structure of Foot and mouth disease virus RNA-dependent RNA-polymerase and its complex with a template-primer RNA Site-specific mutagenesis of AIDS virus reverse transcriptase Point mutations which drastically affect the polymerization activity of encephalomyocarditis virus RNA-dependent RNA polymerase correspond to the active site of Escherichia coli DNA polymerase I Defined mutations in a small region of the brome mosaic virus 2a gene cause diverse temperature-sensitive RNA replication phenotypes I-TASSER server for protein 3D structure prediction I-TASSER: a unified platform for automated protein structure & function prediction Structure of the RNA-dependent RNA polymerase of poliovirus Evolution and taxonomy of positive strand RNA viruses: implications of comparative analysis of amino acid sequences A unified polymerase mechanism for non-homologous DNA & RNA polymerases Initiation of viral RNA-dependent RNA polymerization Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site Crystal structure of complete rhinovirus RNA polymerase suggests front-loading of protein primer A comparison of viral RNA-dependent RNA polymerases The structure of a protein primer-polymerase complex in the initiation of genome replication The palm subdomain-based active site is internally permuted in viral RNA-dependent RNA polymerases of an ancient lineage Poliovirus RNA-dependent RNA polymerase (3Dpol): It is of interest to examine if ArCV-1 RNA dependent RNA polymerase (RdRp) structurally resembles the known RdRp of the dsRNA bacteriophage Փ-6, reovirus, or with other viruses like calciviruses and picornaviruses keywords: amino; analysis; arcv-1; conserved; cryptic; cryptoviruses; dsrna; fig; genome; identity; motif; picornaviruses; polymerase; protein; rdrp; residues; rna; sequence; structure; thumb; virus; viruses cache: cord-278099-ypov9ha3.txt plain text: cord-278099-ypov9ha3.txt item: #333 of 672 id: cord-278123-mq56em3z author: Hasan, Mohammad Rubayet title: Detection of SARS-CoV-2 RNA by direct RT-qPCR on nasopharyngeal specimens without extraction of viral RNA date: 2020-07-24 words: 3941 flesch: 45 summary: RNA extraction is preferable to the use of direct specimens because the extraction process concentrates and purifies the RNA targets and excludes PCR inhibitory substances. This could potentially be due to interfering substances concentrated by the SARS-CoV-2 detection by RT-qPCR without RNA extraction extraction process. keywords: approach; cov-2; qpcr; rna; sars; specimens; standard cache: cord-278123-mq56em3z.txt plain text: cord-278123-mq56em3z.txt item: #334 of 672 id: cord-278224-sq7tokbx author: Protopopova, Alexandra title: Behavioral predictors of subsequent respiratory illness signs in dogs admitted to an animal shelter date: 2019-10-23 words: 7591 flesch: 45 summary: The high levels of cortisol (or corticosterone) inhibit further production of the CRH and ACTH resulting in a negative feedback loop (see [14] for a discussion in shelter dogs). Management of Disease Outbreaks in Animal Shelters Bold personality makes domestic dogs entering a shelter less vulnerable to diseases A placebo-controlled trial of two intranasal vaccines to prevent tracheobronchitis (kennel cough) in dogs entering a humane shelter The effects of exercise and calm interactions on in-kennel behavior of shelter dogs In-kennel behavior predicts length of stay in shelter dogs Development and validation of a body condition score system for dogs Behavior and cortisol levels of dogs in a public animal shelter, and an exploration of the ability of these measures to predict problem behavior after adoption Tools for Partial Least Squares Path Modeling (PLS-PM) keywords: animal; behavior; curiosity; data; day; disease; dogs; illness; kennel; shelter; sociability; study; time cache: cord-278224-sq7tokbx.txt plain text: cord-278224-sq7tokbx.txt item: #335 of 672 id: cord-279259-eu80ccm6 author: Pandey, Aseem title: Impact of Preexisting Adenovirus Vector Immunity on Immunogenicity and Protection Conferred with an Adenovirus-Based H5N1 Influenza Vaccine date: 2012-03-14 words: 4906 flesch: 42 summary: Adenoviruses (Ad) possess several attributes that make them suitable candidates for vaccine vectors [1, 2] . A response of intranasal adenoviral vector human immunodeficiency virus vaccine and localization in the central nervous system Mucosal vaccines: the promise and the challenge Immunogenicity of an E1-deleted recombinant human adenovirus against rabies by different routes of administration Adenovirus-specific human T cells are pervasive, polyfunctional, and crossreactive Route of adenovirus-based HIV-1 vaccine delivery impacts the phenotype and trafficking of vaccine-elicited CD8+ T lymphocytes Phase keywords: cells; dose; groups; i.m; i.n; immunity; vaccine; vector cache: cord-279259-eu80ccm6.txt plain text: cord-279259-eu80ccm6.txt item: #336 of 672 id: cord-279421-rxocrgfu author: Zhang, Dan title: Clinical Evaluation of a Single-Tube Multiple RT-PCR Assay for the Detection of 13 Common Virus Types/Subtypes Associated with Acute Respiratory Infection date: 2016-04-04 words: 2865 flesch: 42 summary: In conclusion, our results demonstrates the one-tube assay revealed significant improvements over the two-tube assay in terms of the better sensitivity, more accurate quality control, less nonspecific amplification, more cost-effective and shorter turn-around time and will be a valuable tool for routine surveillance of respiratory virus infection in China. The aim of this study is to provide a high throughput screening method for routine surveillance of respiratory virus infection in provincial and local Centers for Disease Control and Prevention, China. keywords: assay; detection; study; tube; tube assay; virus; viruses cache: cord-279421-rxocrgfu.txt plain text: cord-279421-rxocrgfu.txt item: #337 of 672 id: cord-280386-a8qr7nl6 author: Pires, Sara M. title: Aetiology-Specific Estimates of the Global and Regional Incidence and Mortality of Diarrhoeal Diseases Commonly Transmitted through Food date: 2015-12-03 words: 5932 flesch: 40 summary: For all other pathogens we included two previously published systematic reviews: 1) the aetiology of diarrhoeal disease studies for children 5 years of age published between 1980 and 2008 Epidemiology and infection Global burden of childhood pneumonia and diarrhoea Global causes of diarrhoeal disease mortality in children <5 years of age: a systematic review Etiology of diarrhea among older children, adolescents, and adults: a systematic review Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study Foodborne illness acquired in the United States-unspecified agents Disease burden of foodborne pathogens in the Netherlands Longitudinal study of infectious intestinal disease in the UK (IID2 study): incidence in the community and presenting to general practice Estimates of the burden of foodborne illness in Canada for 30 specified pathogens and unspecified agents, circa Foodborne illness, Australia, circa 2000 and circa Foodborne infections in France Risk ranking for foodborne microbial hazards in New Zealand: burden of disease estimates Global Incidence of Human Shiga Toxin-Producing Escherichia coli Infections and Deaths: A Systematic Review and Knowledge Synthesis. keywords: age; diarrhoeal; diseases; estimates; incidence; mortality; pathogens; region; studies cache: cord-280386-a8qr7nl6.txt plain text: cord-280386-a8qr7nl6.txt item: #338 of 672 id: cord-280471-cqypwi5d author: Sun, Hua-Bao title: The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19 date: 2020-09-25 words: 4349 flesch: 53 summary: In the patients with COVID-19, the total number of peripheral blood lymphocytes decreased mainly as the number of CD4+ T lymphocytes decreased. In patients with COVID-19, the number of peripheral blood lymphocytes decreased, mainly manifesting as a decrease in the number of CD4+ T lymphocytes, a decrease in the ratio of CD4+/CD8+ lymphocytes, and a decrease in the number of CD8+ lymphocytes; the degrees of these reductions was significantly correlated with the severity of disease. keywords: blood; cd4; covid-19; covid-19 group; group; lymphocytes; number; patients cache: cord-280471-cqypwi5d.txt plain text: cord-280471-cqypwi5d.txt item: #339 of 672 id: cord-280482-o887a7q9 author: Xu, Suming title: Transgenic Mice Expressing MCP-1 by the Urothelium Demonstrate Bladder Hypersensitivity, Pelvic Pain and Voiding Dysfunction: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Animal Model Study date: 2016-09-29 words: 4141 flesch: 38 summary: Supporting Information S1 Monocyte chemoattractant protein-1 (MCP-1): an overview Mycobacterium bovis bacillus Calmette-Gué rin (BCG) induces human CC-and CXC-chemokines in vitro and in vivo Wound healing in MIP-1alpha (-/-) and MCP-1(-/-) mice Mice lacking MCP-1 have enhanced susceptibility to an interstitial polymicrobial infection due to impaired monocyte recruitment Impaired monocyte migration and reduced type 1 (TH1) C-C chemokine receptor 2 knockout mice Increased expression of CCL2 in insulin-producing cells of transgenic mice promotes mobilization of myeloid cells from the bone marrow, marked insulitis, and diabetes Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation Pertussis toxin-induced reversible encephalopathy dependent on monocyte chemoattractant protein-1 overexpression in mice Transgenic CCL2 expression in the central nervous system results in a dysregulated immune response and enhanced lethality after coronavirus infection Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study Differential profile analysis of urinary cytokines in patients with overactive bladder Monocyte chemoattractant protein-1 and macrophage inflammatory protein-1α as possible biomarkers for the chronic pelvic pain syndrome Recruitment of bone marrow derived cells to the bladder after bladder outlet obstruction Urinary concentration and tissue messenger RNA expression of monocyte chemoattractant protein-1 as an indicator of the degree of hydronephrotic atrophy in partial ureteral obstruction Expression and function of CCL2/CCR2 in rat micturition reflexes and somatic sensitivity with urinary bladder inflammation MCP-1-induced histamine release from mast cells is associated with development of interstitial cystitis/bladder pain syndrome in rat models Chronic pelvic allodynia is mediated by CCL2 through mast cells in an experimental autoimmune cystitis model Diagnosis and treatment of interstitial cystitis/bladder pain syndrome: AUA guideline amendment A tissue-specific promoter that can drive a foreign gene to express in the suprabasal urothelial cells of transgenic mice Vectors for high-level expression of cDNAs controlled by tissuespecific promoters in transgenic mice Urinary bladder epithelium antigen induces CD8+ T cell tolerance, activation, and autoimmune response Animal models of urologic chronic pelvic pain syndromes: Findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Gene expression profiling of mouse bladder inflammatory responses to LPS, substance P, and antigen-stimulation Modulating bladder neuro-inflammation: RDP58, a novel anti-inflammatory peptide, decreases inflammation and nerve growth factor production in experimental cystitis Role of inflammation in bladder function and interstitial cystitis Inflammation and inflammatory control in interstitial cystitis/bladder pain syndrome: Although our data indicate the presence of increased pelvic pain sensitivity, we will continue demonstrating bladder pain by using more specific methods such as the bladder distention-evoked visceromotor response (VMR) method [22] . keywords: bladder; c57bl/6; cystitis; inflammation; lps; mcp-1; mice; model; pain; pelvic; uro cache: cord-280482-o887a7q9.txt plain text: cord-280482-o887a7q9.txt item: #340 of 672 id: cord-280846-bbv6f5gf author: Greninger, Alexander L. title: A Metagenomic Analysis of Pandemic Influenza A (2009 H1N1) Infection in Patients from North America date: 2010-10-18 words: 8040 flesch: 37 summary: Treatment with DNase twice yielded the best percentage recovery of However, despite very low viral titers, H1N1 influenza was still detectable by deep sequencing, with 270 and 18 reads aligning to influenza for Cal-UC12 and BC-59, respectively (Table 1) . Emergence of a novel swine-origin influenza A (H1N1) virus in humans Triplereassortant swine influenza A (H1) in humans in the United States Pandemic potential of a strain of influenza A (H1N1): early findings Rapid-test sensitivity for novel swine-origin influenza A (H1N1) virus in humans Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic Metagenomics for the discovery of novel human viruses Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult Microarray-based detection and genotyping of viral pathogens Characterization of a novel coronavirus associated with severe acute respiratory syndrome Viral discovery and sequence recovery using DNA microarrays Pan-viral screening of respiratory tract infections in adults with and without asthma reveals unexpected human coronavirus and human rhinovirus diversity Identification of cardioviruses related to Theiler's murine encephalomyelitis virus in human infections Achalasia and viral infection: new insights from veterinary medicine Recovery of divergent avian bornaviruses from cases of proventricular dilatation disease: identification of a candidate etiologic agent Utility of DNA microarrays for detection of viruses in acute respiratory tract infections in children Identification of a novel astrovirus (astrovirus VA1) associated with an outbreak of acute gastroenteritis The complete genome of klassevirus -a novel picornavirus in pediatric stool Metagenomic analyses of viruses in stool samples from children with acute flaccid paralysis Bat guano virome: predominance of dietary viruses from insects and plants plus novel mammalian viruses Multiple diverse circoviruses infect farm animals and are commonly found in human and chimpanzee feces Genetic detection and characterization of Lujo virus, a new hemorrhagic feverassociated arenavirus from southern Africa A new arenavirus in a cluster of fatal transplant-associated diseases Influenza vaccine-outmaneuvering antigenic shift and drift Broadspectrum respiratory tract pathogen identification using resequencing DNA microarrays Robust sequence selection method used to develop the FluChip diagnostic microarray for influenza virus Panmicrobial oligonucleotide array for diagnosis of infectious diseases Experimental evaluation of the FluChip diagnostic microarray for influenza virus surveillance Detection in 2009 of the swine origin influenza A (H1N1) virus by a subtyping microarray Large-scale evolutionary surveillance of the 2009 H1N1 influenza A virus using resequencing arrays Identifying influenza viruses with resequencing microarrays Detection of molecular markers of drug resistance in the 2009 pandemic influenza A (H1N1) viruses using pyrosequencing Direct metagenomic detection of viral pathogens in nasal and fecal specimens using an unbiased high-throughput sequencing approach Characterization of quasispecies of pandemic 2009 influenza A virus (A/H1N1/ 2009) by de novo sequencing using a next-generation DNA sequencer California Pandemic Working G (2010) Severe 2009 H1N1 influenza in pregnant and postpartum women in California E-Predict: a computational strategy for species identification based on observed DNA microarray hybridization patterns Development and quantitative analyses of a universal rRNA-subtraction protocol for microbial metatranscriptomics The NIH Human Microbiome Project Xenotropic Murine Leukemia Virus-related Gammaretrovirus in Respiratory Tract Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome Antiviral actions of interferons Clonal integration of a polyomavirus in human Merkel cell carcinoma Metagenomic analysis of respiratory tract DNA viral communities in cystic fibrosis and non-cystic fibrosis individuals Streptococcus pneumoniae coinfection is correlated with the severity of H1N1 pandemic influenza RNA viral community in human feces: prevalence of plant pathogenic viruses Substantial biases in ultra-short read data sets from high-throughput DNA sequencing Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein Real-time DNA sequencing from single polymerase molecules The next generation becomes the now generation The long march: a sample preparation technique that enhances contig length and coverage by high-throughput short-read sequencing Kleine-Levin syndrome: a systematic study of 108 patients PANTHER pathway: an ontology-based pathway database coupled with data analysis tools SSAHA: a fast search method for large DNA databases Multiple sequence alignment using ClustalW and ClustalX We thank Aurora París at the Ministry of Health BSL-3 state laboratory in Veracruz for providing 2009 H1N1 samples from Mexico. keywords: analysis; data; detection; genome; h1n1; human; influenza; novel; pcr; reads; samples; sequence; sequencing; virochip; virus; viruses cache: cord-280846-bbv6f5gf.txt plain text: cord-280846-bbv6f5gf.txt item: #341 of 672 id: cord-281124-4nhy35xn author: Soowannayan, Chumporn title: RNA-Binding Domain in the Nucleocapsid Protein of Gill-Associated Nidovirus of Penaeid Shrimp date: 2011-08-03 words: 5634 flesch: 41 summary: GAV N protein also bound to double-stranded (ds)RNAs prepared to GAV ORF1b gene regions and to bacteriophage M13 genomic ssDNA. GAV N protein binding to two dsRNAs was also assessed (Fig. 3B) . keywords: binding; fig; gav; gene; length; protein; rna; sequence; ssrna; virus cache: cord-281124-4nhy35xn.txt plain text: cord-281124-4nhy35xn.txt item: #342 of 672 id: cord-281161-u896icp9 author: Wang, Jing title: The Adjuvanticity of an O. volvulus-Derived rOv-ASP-1 Protein in Mice Using Sequential Vaccinations and in Non-Human Primates date: 2012-05-17 words: 6880 flesch: 41 summary: A number of microbial products, including bacterial LPS, peptidoglycan, dsRNA, muramyl peptides, CpG, flagellin and microbial proteins, were shown to act as vaccine adjuvants [41] [42] Alum's adjuvant action: grease is the word Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity Immunological mechanisms of vaccination Vaccine adjuvants: putting innate immunity to work Adjuvants for the future Recent advances in vaccine adjuvants Rationally-designed vaccine adjuvants: separating efficacy from toxicity Enhancing oral vaccine potency by targeting intestinal M cells Diversity and dialogue in immunity to helminths Immune regulation by helminth parasites: cellular and molecular mechanisms T helper type-2 cytokine responses: potential therapeutic targets Helminth antigens modulate TLR-initiated dendritic cell activation TLR11 activation of dendritic cells by a protozoan profilin-like protein rOv-ASP-1, a recombinant secreted protein of the helminth Onchocerca volvulus, is a potent adjuvant for inducing antibodies to ovalbumin, HIV-1 polypeptide and SARS-CoV peptide antigens Immune evasion genes from filarial nematodes Helminth parasites-masters of regulation A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62 ES-62, a filarial nematode-derived immunomodulator with anti-inflammatory potential Modulation of a heterologous immune response by the products of Ascaris suum Taenia crassiceps carbohydrates stimulate IL-6 expression in naive murine macrophages via Toll-like receptors (TLRs) keywords: adjuvant; antibodies; antibody; asp-1; cpg; mice; protein; responses; rov; rrbd; sars; th1; th2; vaccine cache: cord-281161-u896icp9.txt plain text: cord-281161-u896icp9.txt item: #343 of 672 id: cord-281364-syg0wo77 author: Caì, Yíngyún title: CD26/DPP4 Cell-Surface Expression in Bat Cells Correlates with Bat Cell Susceptibility to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection and Evolution of Persistent Infection date: 2014-11-19 words: 3835 flesch: 44 summary: Our study confirms the role of CD26/DPP4 as receptor for two divergent MERS-CoV isolates and correlates its presence or absence on the surface of bat cells directly with bat cell susceptibility or resistance to productive MERS-CoV infection (Figures 2 and 3 ). Bat cells were washed with phosphate-buffered saline (PBS) and then dissociated with cell dissociation buffer (Life Technologies). keywords: bat; cd26; cells; coronavirus; cov; dpp4; human; infection; lines; mers; syndrome cache: cord-281364-syg0wo77.txt plain text: cord-281364-syg0wo77.txt item: #344 of 672 id: cord-281665-6n7aq4k9 author: Qiu, Sangsang title: Is Tuberculosis Treatment Really Free in China? A Study Comparing Two Areas with Different Management Models date: 2015-05-20 words: 3983 flesch: 46 summary: Epidemiology of anti-tuberculosis drug resistance in a Chinese population: current situation and challenges ahead Economic support to improve tuberculosis treatment outcomes in South Africa: a pragmatic cluster-randomized controlled trial Economic impact of pulmonary tuberculosis on patients and their families of Dharan municipality, Nepal Perception and social consequences of tuberculosis: a focus group study of tuberculosis patients in Sialkot DOTS in China-removing barriers or moving barriers? Progress in tuberculosis control and the evolving public-health system in China Adverse reactions due to directly observed treatment strategy therapy in chinese tuberculosis patients: a prospective study Analysis of the economic burden of diagnosis and treatment of tuberculosis patients in rural China Barriers to TB care for rural-to-urban migrant TB patients in Shanghai: a qualitative study Tuberculosis patient expenditure on drugs and tests in subsidised, public services in China: a descriptive study Effective reimbursement rates of the rural health insurance among uncomplicated tuberculosis patients in China Tuberculosis control in China: striving for sustainability How affordable are tuberculosis diagnosis and treatment in rural China? Under the current “free of diagnosis and treatment” policy, the financial burden remains heavy on tuberculosis patients. keywords: china; costs; health; model; patients; study; treatment; tuberculosis cache: cord-281665-6n7aq4k9.txt plain text: cord-281665-6n7aq4k9.txt item: #345 of 672 id: cord-281815-zvs5qe8x author: Subramanian, Shoba title: Hemoglobin Cleavage Site-Specificity of the Plasmodium falciparum Cysteine Proteases Falcipain-2 and Falcipain-3 date: 2009-04-09 words: 5971 flesch: 38 summary: Reducing requirements for hemoglobin hydrolysis by Plasmodium falciparum cysteine proteases Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2 Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3 Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities A mass spectrometry-based strategy for detecting and characterizing endogenous proteinase activities in complex biological samples Proteolytic 18O-labeling strategies for quantitative proteomics Handbook of Proteolytic Enzymes A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase Folding of the Plasmodium falciparum cysteine protease falcipain-2 is mediated by a chaperone-like peptide and not the prodomain Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2 The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif Structural and functional characterization of Falcipain-2, a hemoglobinase from the malarial parasite Plasmodium falciparum Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease Falcipain cysteine proteases require bipartite motifs for trafficking to the Plasmodium falciparum food vacuole Food vacuole targeting and trafficking of falcipain-2, an important cysteine protease of human malaria parasite Plasmodium falciparum A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity Definition and redesign of the extended substrate specificity of granzyme B Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors Antimalarial activities of novel synthetic cysteine protease inhibitors Quantitative pH measurements in Plasmodium falciparum-infected erythrocytes using pHluorin Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH Antimalarials increase vesicle pH in Plasmodium falciparum Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine Proteolysis of human hemoglobin by schistosome cathepsin D Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine A Plasmodium falciparum dipeptidyl aminopeptidase I participates in vacuolar hemoglobin degradation Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum Plasmodium falciparum falcilysin: a metalloprotease with dual specificity Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function Effects on growth, hemoglobin metabolism and paralogous gene expression resulting from disruption of genes encoding the digestive vacuole plasmepsins of Plasmodium falciparum Plasmodium food vacuole plasmepsins are activated by falcipains Plasmodium falciparum cysteine protease falcipain-2 cleaves erythrocyte membrane skeletal proteins at late stages of parasite development Ankyrin peptide blocks falcipain-2-mediated malaria parasite release from red blood cells A role of falcipain-2, principal cysteine proteases of Plasmodium falciparum in merozoite egression Generation of hemoglobin peptides in the acidic digestive vacuole of Plasmodium falciparum implicates peptide transport in amino acid production Haemoglobin C protects against clinical Plasmodium falciparum malaria Aberrant development of Plasmodium falciparum in hemoglobin CC red cells: implications for the malaria protective effect of the homozygous state Hemoglobin variants and disease manifestations in severe falciparum malaria Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases Protective effects of the sickle cell gene against malaria morbidity and mortality Hemoglobin hydrolysis has been described as an ordered process initiated by aspartic proteases, but cysteine protease inhibitors completely block the process, suggesting that cysteine proteases can also initiate hemoglobin hydrolysis. keywords: amino; cleavage; cysteine; falcipain-2; falciparum; hemoglobin; hydrolysis; peptides; plasmodium; proteases cache: cord-281815-zvs5qe8x.txt plain text: cord-281815-zvs5qe8x.txt item: #346 of 672 id: cord-282194-0sjmf1yn author: Cherak, Stephana J. title: Impact of social media interventions and tools among informal caregivers of critically ill patients after patient admission to the intensive care unit: A scoping review date: 2020-09-11 words: 5412 flesch: 37 summary: Ultimately, the relatively rapid evolution of social media means studies on usage will nearly exclusively reflect social media use of the past. Advances in Patient Safety Lessons Learned From Web-and Social Media-Based Educational Initiatives by Pulmonary The World Federation of Societies of Intensive and Critical Care Medicine Newsletter Online, social media and mobile technologies for psychosis treatment: a systematic review on novel user-led interventions Methods of using real-time social media technologies for detection and remote monitoring of HIV outcomes Social media use in healthcare: A systematic review of effects on patients and on their relationship with healthcare professionals Retiring the Term Futility in Value-Laden Decisions Regarding Potentially Inappropriate Medical Treatment Ethical dilemmas due to the Covid-19 pandemic Bereavement Support on the Frontline of COVID-19: Recommendations for Hospital Clinicians Rehabilitation After Critical Illness in People With COVID-19 Infection Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations We thank Dr. Diane Lorenzetti (University of Calgary) for the development of the search strategies. keywords: care; caregivers; health; media; patient; review; studies; study; use cache: cord-282194-0sjmf1yn.txt plain text: cord-282194-0sjmf1yn.txt item: #347 of 672 id: cord-282202-q2q4vies author: Banerjee, Amitava title: Clinical academic research in the time of Corona: A simulation study in England and a call for action date: 2020-08-13 words: 4111 flesch: 41 summary: Dissemination: across UK and internationally to those considering COVID-19 clinical research. key: cord-282202-q2q4vies authors: Banerjee, Amitava; Katsoulis, Michail; Lai, Alvina G.; Pasea, Laura; Treibel, Thomas A.; Manisty, Charlotte; Denaxas, Spiros; Quarta, Giovanni; Hemingway, Harry; Cavalcante, João L.; Noursadeghi, Mahdad; Moon, James C. title: Clinical academic research in the time of Corona: A simulation study in England and a call for action date: 2020-08-13 journal: PLoS One DOI: 10.1371/journal.pone.0237298 sha: doc_id: 282202 cord_uid: q2q4vies OBJECTIVES: keywords: academic; clinical; covid-19; data; health; infection; mitigation; model; number; pandemic; research cache: cord-282202-q2q4vies.txt plain text: cord-282202-q2q4vies.txt item: #348 of 672 id: cord-282303-idh7io9v author: Hassan, Md. Zakiul title: Contamination of hospital surfaces with respiratory pathogens in Bangladesh date: 2019-10-28 words: 4160 flesch: 32 summary: Muzahidul; Rahman, Mahmudur; Gurley, Emily S. title: Contamination of hospital surfaces with respiratory pathogens in Bangladesh date: 2019-10-28 journal: PLoS One DOI: 10.1371/journal.pone.0224065 sha: doc_id: 282303 cord_uid: idh7io9v With limited infection control practices in overcrowded Bangladeshi hospitals, surfaces may play an important role in the transmission of respiratory pathogens in hospital wards and pose a serious risk of infection for patients, health care workers, caregivers and visitors. Respiratory viral and bacterial pathogens, including Staphylococcus aureus, Streptococcus pyogenes, influenza viruses, respiratory syncytial virus, adenovirus, rhinoviruses and novel coronavirus strains, can survive on hospital surfaces for days, weeks or even months. keywords: hospital; infection; pathogens; patients; pneumoniae; respiratory; surfaces; swabs; wards cache: cord-282303-idh7io9v.txt plain text: cord-282303-idh7io9v.txt item: #349 of 672 id: cord-282668-bs634hti author: Niang, Mbayame Ndiaye title: Respiratory viruses in patients with influenza-like illness in Senegal: Focus on human respiratory adenoviruses date: 2017-03-22 words: 4627 flesch: 42 summary: Molecular Evolutionary Genetics Analysis version 6.0 Epidemiology of respiratory viral infections in two long-term refugee camps in Kenya Viral etiology and seasonality of influenza-like illness in Gabon Epidemiology of respiratory viral infection using multiplex rt-PCR in Laboratory Surveillance of Influenza-Like Illness in Seven Teaching Hospitals The clinical and etiological characteristics of influenza-like illness (ILI) in outpatients in Temporal changes in respiratory adenovirus serotypes circulating in the greater Toronto area Adenovirus respiratory tract infections in Peru Sentinel surveillance of influenza-like illness in two hospitals in Respiratory viral infections during the 2009-2010 winter season in Central England, UK: incidence and patterns of multiple virus co-infections Viral etiology of severe acute respiratory infections in hospitalized children in Cameroon The role of respiratory viral infections among children hospitalized for community-acquired pneumonia in a developing country Respiratory Virus Detection and Clinical Diagnosis in Children Attending Day Care Surveillance for severe acute respiratory infections in Southern Arizona Epidemiology of human respiratory viruses in children with acute respiratory tract infections in Jinan, China Respiratory viral infection in lower airways of asymptomatic children Viral and Other Infections of the Human Respiratory Tract The epidemiology of adenovirus infections in Greater Manchester, UK 1982-96 Estimates of world-wide distribution of child deaths from acute respiratory infections Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis Molecular identification of adenoviruses associated with respiratory infection in Egypt from Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China Feigin RD, Cherry JD. keywords: adenovirus; children; detection; hadv; human; infections; influenza; patients; senegal; species; study; years cache: cord-282668-bs634hti.txt plain text: cord-282668-bs634hti.txt item: #350 of 672 id: cord-283604-fqc9jp0l author: Chen, Meng title: Adenoviruses Associated with Acute Respiratory Diseases Reported in Beijing from 2011 to 2013 date: 2015-03-27 words: 3066 flesch: 36 summary: Seventh Report of the International Committee on Taxonomy of Viruses New adenovirus species found in a patient presenting with gastroenteritis Evidence of frequent recombination among human adenoviruses Molecular and serological characterization of species B2 adenovirus strains isolated from children hospitalized with acute respiratory disease in Genome sequence of a novel virus of the species human adenovirus d associated with acute gastroenteritis Molecular epidemiology of human adenoviruses d associated with epidemic keratoconjunctivitis in Rapid detection of adenovirus in throat swab specimens by PCR during respiratory disease outbreaks among military recruits Abrupt emergence of diverse species B adenoviruses at US military recruit training centers Multiplexed Luminex xMAP assay for detection and identification of five adenovirus serotypes associated with epidemics of respiratory disease in adults Outbreak of acute respiratory disease in China caused by B2 species of adenovirus type 11 Genomic analyses of recombinant adenovirus type 11a in China High incidence of multiple viral infections identified in upper respiratory tract infected children under three years of age in MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods Detection of three human adenovirus species in adults with acute respiratory infection in China Human adenovirus infection in children with acute respiratory tract disease in Guangzhou Prevalence of adenovirus in children with acute respiratory tract infection in Lanzhou, China Molecular typing of adenoviruses in pediatric respiratory infections in Molecular epidemiology and clinical presentation of human adenovirus infections in Kansas City children Molecular identification of adenoviruses associated with respiratory infection in Egypt from Lower respiratory tract infections due to adenovirus in hospitalized Korean children: epidemiology, clinical features, and prognosis Natural variants of human adenovirus type 3 provide evidence for relative genome stability across time and geographic space Genomic and bioinformatics analyses of HAdV-4vac and HAdV-7vac, two human adenovirus (HAdV) strains that constituted original prophylaxis against HAdV-related acute respiratory disease, a reemerging epidemic disease Computational analysis of adenovirus serotype 5 (HAdV-C5) from an HAdV coinfection shows genome stability after 45 years of circulation Outbreak of febrile respiratory illness associated with adenovirus 11a infection in a Singapore military training cAMP Emergence of community-acquired adenovirus type 55 as a cause of community-onset pneumonia Severe community-acquired pneumonia caused by adenovirus type 11 in immunocompetent adults in Beijing Epidemiology of human adenovirus and molecular characterization of human adenovirus 55 in China Evidence of molecular evolution driven by recombination events influencing tropism in a novel human adenovirus that causes epidemic keratoconjunctivitis Computational analysis identifies human adenovirus type 55 as a re-emergent acute respiratory disease pathogen We thank all the laboratory staffs and the epidemiologists in Beijing Center for Disease Control and Prevention and team members in the projects. key: cord-283604-fqc9jp0l authors: Chen, Meng; Zhu, Zhen; Huang, Fang; Liu, Donglei; Zhang, Tiegang; Ying, Deng; Wu, Jiang; Xu, Wenbo title: Adenoviruses Associated with Acute Respiratory Diseases Reported in Beijing from 2011 to 2013 date: 2015-03-27 journal: PLoS One DOI: 10.1371/journal.pone.0121375 sha: doc_id: 283604 cord_uid: fqc9jp0l BACKGROUND: Adenovirus is one of the most common causes of viral acute respiratory infections. keywords: adenovirus; gene; hadv; human; infection; species; study; type cache: cord-283604-fqc9jp0l.txt plain text: cord-283604-fqc9jp0l.txt item: #351 of 672 id: cord-283976-jgae7r2q author: Armstrong, Melissa J. title: Research priorities of caregivers and individuals with dementia with Lewy bodies: An interview study date: 2020-10-07 words: 4114 flesch: 33 summary: The Rotterdam Study The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease Care burden and mental ill health in spouses of people with Parkinson disease dementia and Lewy body dementia Caregiver burden in family carers of people with dementia with Lewy bodies and Alzheimer's disease Clinical findings, functional abilities and caregiver distress in the early stage of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) Examining carer stress in dementia: the role of subtype diagnosis and neuropsychiatric symptoms Patients with dementia with Lewy bodies have more impaired quality of life than patients with Alzheimer disease Trajectories and determinants of quality of life in dementia with Lewy bodies and Alzheimer's disease Priority setting partnership to identify the top 10 research priorities for the management of Parkinson's disease Living with Parkinson's disease: priorities for research suggested by patients Dementia priority setting partnership with the James Lind Alliance: using patient and public involvement to inform the research agenda National priorities for dementia care: perspectives of individuals living with dementia and their care partners Priorities for people living with dementia: education, counseling, research Patient and public involvement in identifying dementia research priorities Qualitative descriptive methods in health science research Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups Lewy body dementias National Research Summit on Care, Services, and Supports for Persons with Dementia and Their Caregivers: Final Summit Report Development of assessment toolkits for improving the diagnosis of the Lewy body dementias: feasibility study within the DIAMOND Lewy study Lewy body dementia: the caregiver experience of clinical care Caregiver-reported barriers to quality end-of-life care in dementia with Lewy bodies: a qualitative analysis End-of-life experiences in dementia with Lewy bodies: Qualitative interviews with former caregivers Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases Research questions asked about participant priorities for DLB research in general and then specifically queried participant priorities regarding research on DLB symptoms, daily challenges, caregiving/family life, and diagnosis. keywords: caregivers; dementia; dlb; individuals; lewy; participants; priorities; research; study cache: cord-283976-jgae7r2q.txt plain text: cord-283976-jgae7r2q.txt item: #352 of 672 id: cord-284016-zb6cv8ik author: Li, Wei title: Activation of Interleukin-32 Pro-Inflammatory Pathway in Response to Influenza A Virus Infection date: 2008-04-16 words: 4231 flesch: 39 summary: Although pro-inflammatory factor COX-2 has been identified as an obligatory mediator in the airway inflammation during influenza virus infection [26] , virtually little is currently known regarding the regulation of a newly identified proinfammatory factor IL-32 in influenza A virus infection or the mechanism whereby influenza A virus upregulates IL-32 expression. Interestingly, we found that COX-2-associate PGE(2) production activated by influenza virus infection was significantly suppressed by over-expression of IL-32 but increased by IL-32-specific siRNA, suggesting there was a feedback mechanism between IL-32 and COX-2. keywords: cells; cox-2; expression; fig; il-32; infection; inflammatory; influenza; pge; production; virus cache: cord-284016-zb6cv8ik.txt plain text: cord-284016-zb6cv8ik.txt item: #353 of 672 id: cord-284275-bqo203pf author: Lu, Roujian title: Characterization of Human Coronavirus Etiology in Chinese Adults with Acute Upper Respiratory Tract Infection by Real-Time RT-PCR Assays date: 2012-06-15 words: 2979 flesch: 50 summary: Update on rhinovirus and coronavirus infections Identification of a new human coronavirus Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia Identification of a novel coronavirus in patients with severe acute respiratory syndrome A novel coronavirus associated with severe acute respiratory syndrome A previously undescribed coronavirus associated with respiratory disease in humans Viruses and bacteria in the etiology of the common cold A cluster of cases of severe acute respiratory syndrome in Hong Kong Croup is associated with the novel coronavirus NL63 Respiratory coronavirus infections in children younger than two years of age Coronavirus 229E-related pneumonia in immunocompromised patients Coronavirus HKU1 infection in the United States Human respiratory coronavirus HKU1 versus other coronavirus infections in Italian hospitalised patients Detection of human coronavirus NL63, human metapneumovirus and respiratory syncytial virus in children with respiratory tract infections in southwest Sweden Evidence of human coronavirus HKU1 and human bocavirus in Australian children Detection of human coronavirus-NL63 in children in Japan Human coronaviruses infections in rural Tailand: A comprehensive study using real-time reverse-transcription polymerase chain reaction assays Detection of Four Human Coronaviruses in Respiratory Infections in Children: A One-Year Study in Colorado Impact of human coronavirus infections in otherwise healthy children who attended an emergency department Human coronavirus and acute respiratory illness in older adults with chronic obstructive pulmonary disease Coronavirus infection and hospitalizations for acute respiratory illness in young children An outbreak of coronavirus OC43 respiratory infection in Normandy, France Epidemiology and Clinical Presentations of the Four Human Coronaviruses 229E, HKU1, NL63, and OC43 Detected over 3 Years Using a Novel Multiplex Real-Time PCR Method Prevalence of Human Coronaviruses in Adults With Acute Respiratory Tract Infections in Beijing Laboratory Diagnosis and Surveillance of Human Respiratory Viruses by PCR in Etiology and clinical characterization of respiratory virus infections in adult patients attending an emergency department in Beijing Molecular assays for detection of human metapneumovirus Epidemiological profil and clinical associations of human bocavirus and other human parvoviruses Coronavirus HKU1 and other coronavirus infections in Hong Kong Human (nonsevere acute respiratory syndrome) coronavirus infections in hospitalized children in France Clinical disease in children associated with newly described coronavirus subtypes Detection of human coronaviruses in children with acute gastroenteritis A prospective hospital-based study of the clinical impact of non-severe acute respiratory syndrome (Non-SARS)-related human coronavirus infection Seroepidemiology of group I human coronaviruses in children Acute respiratory infection and influenza-like illness viral etiologies in Brazilian adults The common cold Molecular diagnosis of respiratory virus infections Use of sensitive, broad-spectrum molecular assays and human airway epithelium cultures for detection of respiratory pathogens Our results suggest that testing algorithms that include sensitive HCoVs detection contribute to the likelihood of obtaining a laboratory diagnosis when respiratory virus infection is suspected [26, [37] keywords: coronavirus; hcovs; hku1; human; infection; patients; pcr cache: cord-284275-bqo203pf.txt plain text: cord-284275-bqo203pf.txt item: #354 of 672 id: cord-284501-5i0w74q4 author: Armesto, Maria title: The Replicase Gene of Avian Coronavirus Infectious Bronchitis Virus Is a Determinant of Pathogenicity date: 2009-10-09 words: 8008 flesch: 47 summary: Comparative analysis of complete genome sequences of three avian coronaviruses reveals a novel group 3c coronavirus Identification of a novel coronavirus from a beluga whale by using a panviral microarray Detection of a novel and highly divergent coronavirus from asian leopard cats and Chinese ferret badgers in Southern China Infectious bronchitis Avian coronavirus diseases and infectious bronchitis vaccine development Coronavirus avian infectious bronchitis virus Infectious Bronchitis Nidovirus genome organization and expression mechanisms Gene 5 of the avian coronavirus infectious bronchitis virus is not essential for replication Neither the RNA nor the proteins of open reading frames 3a and 3b of the coronavirus infectious bronchitis virus are essential for replication Transmissible gastroenteritis coronavirus gene 7 is not essential but influences in vivo virus replication and virulence Heterologous gene expression from transmissible gastroenteritis virus replicon particles Engineering the transmissible gastroenteritis virus genome as an expression vector inducing lactogenic immunity Live, attenuated coronavirus vaccines through the directed deletion of group-specific genes provide protection against feline infectious peritonitis Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice Recombinant avian infectious bronchitis virus expressing a heterologous spike gene demonstrates that the spike protein is a determinant of cell tropism Generation of a recombinant avian coronavirus infectious bronchitis virus using transient dominant selection Recombinant infectious bronchitis coronavirus Beaudette with the spike protein gene of the pathogenic M41 strain remains attenuated but induces protective immunity Effect of serial embryo passage of an Arkansas-type avian infectious bronchitis virus isolate on clinical response, virus recovery and immunity Attenuation, safety and efficacy of an infectious bronchitis virus GA98 serotype vaccine Development and use of the H strain of avian infectious bronchitis virus from The Netherlands as a vaccine: a review The pathogenesis of virulent and avirulent avian infectious bronchitis virus Characterization of a replicating and packaged defective RNA of avian coronavirus infectious bronchitis virus Replication and packaging of coronavirus infectious bronchitis virus defective RNAs lacking a long open reading frame Leader switching occurs during the rescue of defective RNAs by heterologous strains of the coronavirus infectious bronchitis virus Coronavirus IBV: partial amino terminal sequencing of spike polypeptide S2 identifies the sequence Arg-Arg-Phe-Arg-Arg at the cleavage site of the spike precursor propolypeptide of IBV strains Beaudette and M41 Reverse genetics system for the avian coronavirus infectious bronchitis virus Taxonomic studies on strains of avian infectious bronchitis virus using neutralisation tests in tracheal organ cultures Transient dominant selection for the modification and generation of recombinant infectious bronchitis coronaviruses Expression of bacteriophage T7 RNA polymerase in avian and mammalian cells by a recombinant fowlpox virus The use of chicken tracheal organ cultures for the isolation and assay of avian infectious bronchitis virus Completion of the sequence of the genome of the coronavirus avian infectious bronchitis virus A new DNA sequence assembly program Sequences of the nucleocapsid genes from two strains of avian infectious bronchitis virus Open Reading Frames 3a and 3b of Infectious bronchitis virus cis-Acting Sequences Required for Coronavirus Infectious Bronchitis Virus Defective-RNA Replication and Packaging Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: differences in pathogenesis map to the 39 one-third of the genome Altered pathogenicity, immunogenicity, tissue tropism and 39-7 kb region sequence of an avian infectious coronavirus strain after serial passage in embryos. A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae Turkey coronavirus is more closely related to avian infectious bronchitis virus than to mammalian coronaviruses: a review Detection of a coronavirus from turkey poults in Europe genetically related to infectious bronchitis virus of chickens Complete genomic sequence of turkey coronavirus Complete nucleotide sequence of polyprotein gene 1 and genome organization of turkey coronavirus Coronaviruses from pheasants (Phasianus colchicus) are genetically closely related to coronaviruses of domestic fowl (infectious bronchitis virus) and turkeys Molecular identification and characterization of novel coronaviruses infecting graylag geese (Anser anser), feral pigeons (Columbia livia) and mallards (Anas platyrhynchos) keywords: cells; chickens; gene; ibv; m41; rbeaur; rep; replicase; sequence; struct-2; virus cache: cord-284501-5i0w74q4.txt plain text: cord-284501-5i0w74q4.txt item: #355 of 672 id: cord-285433-ehnu83qe author: Sun, Hongliu title: Detection of Cytomegalovirus Antibodies Using a Biosensor Based on Imaging Ellipsometry date: 2015-08-21 words: 4705 flesch: 50 summary: The key immune methods used for CMV antibody detection are: enzyme-linked immunosorbent assay (ELISA) Additionally, new immune methods for CMV antibody detection have been developed, such as the chemiluminesent microparticle immunoassay (CMIA) keywords: antibodies; antibody; areas; cmv; control; detection; grayscale; igg; serum; value cache: cord-285433-ehnu83qe.txt plain text: cord-285433-ehnu83qe.txt item: #356 of 672 id: cord-285546-5tjhdczt author: Green, Manfred S. title: The confounded crude case-fatality rates (CFR) for COVID-19 hide more than they reveal—a comparison of age-specific and age-adjusted CFRs between seven countries date: 2020-10-21 words: 2390 flesch: 61 summary: Similarity in case fatality rates (CFR) of COVID-19/SARS-COV-2 in Italy and China Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy Early estimation of the case fatality rate of COVID-19 in mainland China: a data-driven analysis Potential biases in estimating absolute and relative case-fatality risks during outbreaks Covid-19: death rate is 0.66% and increases with age, study estimates Estimates of the severity of coronavirus disease 2019: a model-based analysis Aggiornamento nazionale The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19)-China, 2020. The age-adjusted CFRs were computed by the direct method, using the combined number of cases in all seven countries in each age group as the standard population. keywords: age; cases; cfrs; countries cache: cord-285546-5tjhdczt.txt plain text: cord-285546-5tjhdczt.txt item: #357 of 672 id: cord-285749-0ejhd9nw author: Hoffmann, Markus title: The Hemagglutinin of Bat-Associated Influenza Viruses Is Activated by TMPRSS2 for pH-Dependent Entry into Bat but Not Human Cells date: 2016-03-30 words: 6052 flesch: 41 summary: BatFLUAV-HAL does not use sialic acids for host cell entry FLUAV employ alpha-2,3-(avian viruses) and alpha-2,6-linked (human viruses) sialic acids as receptors for host cell entry [47] Finally, the type II transmembrane serine protease TMPRSS2 was able to activate HAL for cell entry indicating that batFLUAV can utilize human proteases for HAL activation. keywords: batfluav; cells; entry; hal; human; influenza; proteins; pseudotypes; tmprss2; trypsin; virus; viruses cache: cord-285749-0ejhd9nw.txt plain text: cord-285749-0ejhd9nw.txt item: #358 of 672 id: cord-286065-x0g67pnb author: Metzgar, David title: The IRIDICA BAC BSI Assay: Rapid, Sensitive and Culture-Independent Identification of Bacteria and Candida in Blood date: 2016-07-06 words: 5932 flesch: 34 summary: PCR-based rapid sepsis diagnosis effectively guides clinical treatment in patients with new onset of SIRS Laboratory detection of sepsis: biomarkers and molecular approaches EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units Burden of illness imposed by severe sepsis in Germany Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock The potential for PCR based testing to improve diagnosis and treatment of sepsis Community-acquired bloodstream infection in critically ill adult patients: impact of shock and inappropriate antibiotic therapy on survival Multiplex real-time PCR and blood culture for identification of bloodstream pathogens in patients with suspected sepsis Benefit of appropriate empirical antibiotic treatment: thirty-day mortality and duration of hospital stay Delaying the empiric treatment of Candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality Improved detection of blood stream pathogens by real-time PCR in severe sepsis Blood cultures: key elements for best practices and future directions A comprehensive model to optimize the strategy for diagnosing bacteremia The clinical and prognostic importance of positive blood cultures in adults Blood culture contamination: persisting problems and partial progress A critical appraisal of the role of the clinical microbiology laboratory in the diagnosis of bloodstream infections Interference testing in clinical chemistry; approved guideline. keywords: assay; bac; bac bsi; blood; bsi; bsi assay; culture; iridica; iridica bac; negative; organisms; pcr; samples; species cache: cord-286065-x0g67pnb.txt plain text: cord-286065-x0g67pnb.txt item: #359 of 672 id: cord-286404-eggkqq3b author: Strayer, David R. title: Effect of disease duration in a randomized Phase III trial of rintatolimod, an immune modulator for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome date: 2020-10-29 words: 5450 flesch: 41 summary: The most frequent adverse event is a limited flu-like syndrome (consisting of headache, chills, fever, flushing, and myalgia) that occurs in approximately 44-45% of rintatolimod patients vs. 30-33% of placebo patients. The proportion of rintatolimod patients improving ETT by �25% was statistically similar for those with sudden onset (38.7%) and for those with slow onset (39.5%). keywords: cfs; duration; ett; fatigue; patients; placebo; population; rintatolimod; subset; target cache: cord-286404-eggkqq3b.txt plain text: cord-286404-eggkqq3b.txt item: #360 of 672 id: cord-286613-cmtsu73g author: Lee, Sung Woo title: Risk Factors for Acute Kidney Injury and In-Hospital Mortality in Patients Receiving Extracorporeal Membrane Oxygenation date: 2015-10-15 words: 3608 flesch: 53 summary: BMC anesthesiology Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome A meta-analysis of complications and mortality of extracorporeal membrane oxygenation Complications of extracorporeal membrane oxygenation for treatment of cardiogenic shock and cardiac arrest: a meta-analysis of 1,866 adult patients RIFLE classification is predictive of shortterm prognosis in critically ill patients with acute renal failure supported by extracorporeal membrane oxygenation Acute kidney injury in adult postcardiotomy patients with extracorporeal membrane oxygenation: evaluation of the RIFLE classification and the Acute Kidney Injury Network criteria Acute kidney injury is a frequent complication in critically ill neonates receiving extracorporeal membrane oxygenation: a 14-year cohort study Renal function and survival in 200 patients undergoing ECMO therapy A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study KDIGO clinical practice guideline for acute kidney injury RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank SAPS 3 at dialysis commencement is predictive of hospital mortality in patients supported by extracorporeal membrane oxygenation and acute dialysis Prognostic consequences of borderline dysnatremia: pay attention to minimal serum sodium change Pump-induced hemolysis in a rabbit model of neonatal ECMO Extracorporeal membrane oxygenation using a centrifugal pump and a servo regulator to prevent negative inlet pressure Flow dynamics of different adult ECMO systems: a clinical evaluation Hemolysis is associated with acute kidney injury during major aortic surgery Hemolysis in pediatric patients receiving centrifugalpump extracorporeal membrane oxygenation: prevalence, risk factors, and outcomes Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients. With every increment in SAPS2, serum sodium level, and ECMO pump speed (1 score in SAPS2, 1 mmol/L in serum sodium level, and 1,000 rpm in ECMO pump speed), the risks of in-hospital mortality were increased, with HRs (95% CI, p-value) of 1.02 (1.004-1.035, 0.01), 1.042 (1.014-1.070, 0.003) and 1.333 (1.020-1.742, 0.04), respectively ( Table 2) . keywords: aki; ecmo; hospital; mortality; patients; pump; stage cache: cord-286613-cmtsu73g.txt plain text: cord-286613-cmtsu73g.txt item: #361 of 672 id: cord-286708-igu984oc author: Chua, Kaw Bing title: Identification and Characterization of a New Orthoreovirus from Patients with Acute Respiratory Infections date: 2008-11-25 words: 4366 flesch: 47 summary: The discovery of Kampar virus highlights the increasing trend of emergence of bat zoonotic viruses and the need to expand our understanding of bats as a source of many unknown viruses. In conclusion, the discovery and characterization of KamV corroborate our previous work on MelV and demonstrate the increasing risk posed by unknown bat viruses which are capable of infecting and causing disease in humans. keywords: bats; case; fruit; human; kampar; kamv; melv; nbv; species; virus; viruses cache: cord-286708-igu984oc.txt plain text: cord-286708-igu984oc.txt item: #362 of 672 id: cord-286837-j2sqs20q author: Koetsier, Antonie title: Do Intensive Care Data on Respiratory Infections Reflect Influenza Epidemics? date: 2013-12-31 words: 4530 flesch: 45 summary: We explored whether ICU data reflect influenza like illness (ILI) activity in the general population, and whether ICU respiratory infections can predict influenza epidemics. In addition, ICU data of the first three years was used to build three regression models to predict the start and end of influenza epidemics in the years thereafter, one to three weeks ahead. keywords: admissions; data; epidemics; icu; ili; incidence; influenza; week cache: cord-286837-j2sqs20q.txt plain text: cord-286837-j2sqs20q.txt item: #363 of 672 id: cord-287739-58fth3xl author: Huang, Yhu-Chering title: Successful Control of Methicillin-Resistant Staphylococcus aureus in Endemic Neonatal Intensive Care Units—A 7-Year Campaign date: 2011-08-12 words: 3824 flesch: 35 summary: The reduction of MRSA infection was gradual and significantly; it appeared to occur prominently for two specific time periods, from 2001 to 2002 and from 2004 to 2005. In contrast, the rate of MRSA infection among the non-colonized infants was similar during both periods; even, MRSA HA infection rate increased slightly in 2007 when the strategy of 'search and destroy' was discontinued since the supported grant was due. keywords: aureus; infection; isolates; methicillin; mrsa; nicus; staphylococcus cache: cord-287739-58fth3xl.txt plain text: cord-287739-58fth3xl.txt item: #364 of 672 id: cord-287761-73qgx58i author: Aly, Mahmoud title: Occurrence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) across the Gulf Corporation Council countries: Four years update date: 2017-10-13 words: 3394 flesch: 50 summary: Next, we sought out the detailed demographic distributions of reported cases among 14 governorates in Saudi Arabia. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an invitro and ex-vivo study Prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Abu Dhabi Emirate Infection control and MERS-CoV in health-care workers MERS coronovirus has probably been present in bats for many years, research shows Link to MERS virus underscores bats' puzzling threat Genetic characterization of Betacoronavirus lineage C viruses in bats reveals marked sequence divergence in the spike protein of pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications for the origin of the novel Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus in bats, Saudi Arabia MERS coronavirus neutralizing antibodies in camels Animal models of Middle East respiratory syndrome coronavirus infection MERS-CoV keywords: cases; coronavirus; cov; east; infections; mers; middle; region cache: cord-287761-73qgx58i.txt plain text: cord-287761-73qgx58i.txt item: #365 of 672 id: cord-287784-f7usy52w author: Maestre, Ana M. title: Equine Torovirus (BEV) Induces Caspase-Mediated Apoptosis in Infected Cells date: 2011-06-15 words: 9019 flesch: 39 summary: The slight reduction in the percentage of apoptotic cells upon treatment of infected cells with the caspase-9 inhibitor could suggest that the mitochondrial apoptotic pathway may be triggered by caspase-8-mediated cleavage of the pro-apoptotic protein Bid. Here, we report the first biochemical study of the effects caused by a torovirus in the infected cells, and show that typical morphological and biochemical features of apoptosis are induced in BEV infected cells. keywords: apoptosis; apoptotic; bev; caspase; cells; cleavage; derm; e. derm; hpi; infected; infection; protein; rna; torovirus; virus cache: cord-287784-f7usy52w.txt plain text: cord-287784-f7usy52w.txt item: #366 of 672 id: cord-288440-w7g2agaf author: Jia, Rui title: The C-Terminal Sequence of IFITM1 Regulates Its Anti-HIV-1 Activity date: 2015-03-04 words: 4924 flesch: 47 summary: The virus stocks were named HIV-1 NL4-3 /BlaM-Vpr that has HIV-1 envelope protein, and NLENY1/VSV-G/BlaM-Vpr that has the VSV-G protein as the envelope, respectively. Mouse IFITM1 diminishes HIV-1 entry IFITM1 orthologs from different species are highly conserved, except for mouse and rat IFITM1 that have shortened C-termini (Fig. 4A ). keywords: bh10; cells; env; fig; human; ifitm1; nl4; protein; virus cache: cord-288440-w7g2agaf.txt plain text: cord-288440-w7g2agaf.txt item: #367 of 672 id: cord-288502-qqg41daz author: Martini, Katharina title: Patterns of organizing pneumonia and microinfarcts as surrogate for endothelial disruption and microangiopathic thromboembolic events in patients with coronavirus disease 2019 date: 2020-10-05 words: 3619 flesch: 42 summary: One hypothesis is, that the high mortality observed among COVID-19 patients may be partly due to undiagnosed pulmonary embolism (PE) and pulmonary in situ thrombosis, outlining the possible role of CT pulmonary angiography (CT-PA) in patients with rapid clinical worsening On CT-PA, 13.2% of COVID-19 patients presented with PE whereas in the control-groups prevalence of PE was 9.1% and 8.9%, respectively (p = 0.452). keywords: artery; changes; cohort; covid-19; patients; pneumonia; ratio cache: cord-288502-qqg41daz.txt plain text: cord-288502-qqg41daz.txt item: #368 of 672 id: cord-289017-vwye3pk9 author: Comach, Guillermo title: Sentinel Surveillance of Influenza-Like Illness in Two Hospitals in Maracay, Venezuela: 2006–2010 date: 2012-09-11 words: 6275 flesch: 44 summary: Influenza viruses, including pandemic H1N1 2009, were the most frequently detected pathogens, accounting for 67.4% (97/144) of the viruses detected. CONCLUSIONS/SIGNIFICANCE: Influenza viruses were the most commonly detected viral organisms among patients with acute febrile respiratory illnesses presenting at two hospitals in Maracay, Venezuela. keywords: detection; ili; influenza; pandemic; pcr; ph1n1; study; surveillance; venezuela; viral; viruses cache: cord-289017-vwye3pk9.txt plain text: cord-289017-vwye3pk9.txt item: #369 of 672 id: cord-289093-si8btsab author: Beard, Philippa M. title: A Loss of Function Analysis of Host Factors Influencing Vaccinia virus Replication by RNA Interference date: 2014-06-05 words: 6591 flesch: 44 summary: To investigate this complex pathogen-host relationship further, a RNAi screen of druggable host targets was carried out to analyse the effect of cellular protein depletion on VACV replication, using a multi-cycle VACV infection assay that monitors all stages of virus replication including virus spread. This resulted in a Pearson product moment correlation coefficient of 0.86, confirming that fluorescence was a reliable determinant of virus replication. keywords: analysis; cells; data; figure; gene; hfs; host; infection; proteins; replication; rnai; screen; sirna; vaccinia; vacv; virus cache: cord-289093-si8btsab.txt plain text: cord-289093-si8btsab.txt item: #370 of 672 id: cord-289285-aof7xy13 author: Michaelis, Martin title: Glycyrrhizin Exerts Antioxidative Effects in H5N1 Influenza A Virus-Infected Cells and Inhibits Virus Replication and Pro-Inflammatory Gene Expression date: 2011-05-17 words: 4332 flesch: 36 summary: Phospholipid biosynthesis from native and organometallic precursors Quantitative analysis of cellular proteome alterations in human influenza A virus-infected mammalian cell lines Nuclear factor 90 negatively regulates influenza virus replication by interacting with viral nucleoprotein Inflammatory responses in influenza A virus infection Role of apoptosis and cytokines in influenza virus morbidity Apoptosis and pathogenesis of avian influenza A (H5N1) virus in humans The A549 cell line, derived from a human pulmonary adenocarcinoma, is an established model for type II pneumocytes [36] , and commonly used for the investigation of the effect of influenza viruses on this cell type [see e.g. 6,37,38]. keywords: a549; cells; concentrations; expression; figure; glycyrrhizin; h5n1; infection; influenza; replication; virus cache: cord-289285-aof7xy13.txt plain text: cord-289285-aof7xy13.txt item: #371 of 672 id: cord-289305-mfjyjjer author: Lee, Min Hye title: A systematic review on the causes of the transmission and control measures of outbreaks in long-term care facilities: Back to basics of infection control date: 2020-03-10 words: 7552 flesch: 46 summary: Three of them were long-lasting outbreaks with multiple clusters for more than 6 months, which suggested that an accurate identification of how pathogens spread was a fundamental step in outbreak control. Forming a local support network between acute hospitals and LTCFs at a regional level would be a potential way to close the gaps and to enhance outbreak control practices in LTCFs without adequate capacity [74] . keywords: care; control; hand; hygiene; infection; influenza; ltcfs; measures; outbreaks; review; studies; study; transmission cache: cord-289305-mfjyjjer.txt plain text: cord-289305-mfjyjjer.txt item: #372 of 672 id: cord-289510-spmknns5 author: Curado, Evaldo M. F. title: A discrete-time-evolution model to forecast progress of Covid-19 outbreak date: 2020-10-29 words: 5923 flesch: 62 summary: From this data set we can build the time series of symptomatic infected people fI UK ðtÞg 133 t¼1 , and asymptomatic infected people fA UK ðtÞg 119 t¼1 (Fig 3) . Notice that here the total number of inhabitants of a country is not an important parameter, as it is in other disease models. keywords: data; day; model; number; people; time cache: cord-289510-spmknns5.txt plain text: cord-289510-spmknns5.txt item: #373 of 672 id: cord-289555-1z4vbldd author: Mühldorfer, Kristin title: Diseases and Causes of Death in European Bats: Dynamics in Disease Susceptibility and Infection Rates date: 2011-12-28 words: 5766 flesch: 38 summary: For hypotheses A and B, we used a generalized linear mixed modeling approach (binomial GLMM using function lmer in library lme4) with bat species included as random effect. Additional findings of our parasite analyses are distinct variations in ecto-and endoparasite prevalence in relation to bat species. keywords: age; bacterial; bats; differences; disease; european; germany; infection; mortality; prevalence; species; table cache: cord-289555-1z4vbldd.txt plain text: cord-289555-1z4vbldd.txt item: #374 of 672 id: cord-289873-6hivjqof author: Lu, Rui title: Patients with mild and general COVID-19 should be negative for at least 3 consecutive nucleic acid tests before discharged date: 2020-10-02 words: 1693 flesch: 46 summary: Meanwhile, if COVID-19 patients who met other discharge criteria were tested for 3 consecutive nucleic acids (median test time was 23 days), the positive rate of nucleic acid test after three nucleic acid tests might be 5.26%. Patients met the following inclusion criteria were included in this study: (1) patients with mild and general COVID-19 [3] ; (2) Patients with complete self-care ability; (3) patients diagnosed with COVID-19 through nucleic acid test. keywords: acid; nucleic; patients cache: cord-289873-6hivjqof.txt plain text: cord-289873-6hivjqof.txt item: #375 of 672 id: cord-289892-yh1lioyz author: Bai, Bingke title: Virus-Like Particles of SARS-Like Coronavirus Formed by Membrane Proteins from Different Origins Demonstrate Stimulating Activity in Human Dendritic Cells date: 2008-07-16 words: 5461 flesch: 49 summary: The observed difference in DC-stimulating activity between BVLPs and SARS CoV VLPs was very likely due to the S protein. Therefore, we compared the phenotypic and functional changes of immature DCs inoculated with BVLPs or with SARS CoV VLPs. keywords: bvlps; cells; coronavirus; cov; dcs; human; protein; sars; study cache: cord-289892-yh1lioyz.txt plain text: cord-289892-yh1lioyz.txt item: #376 of 672 id: cord-290034-4b0mshqa author: Le, Yen H. title: Virus detections among patients with severe acute respiratory illness, Northern Vietnam date: 2020-05-12 words: 2835 flesch: 38 summary: Emerging infectious diseases Etiology and clinical outcomes of acute respiratory virus infection in hospitalized adults Enterovirus Infection in Adults Presenting with Nonspecific Febrile Illness during Summer Evolution and spatiotemporal dynamics of enterovirus A71 subgenogroups in Vietnam. The majority of study patients (62.4%) were female and all study patients were aged 15 years or older. keywords: influenza; military; patients; sari; study; virus; viruses cache: cord-290034-4b0mshqa.txt plain text: cord-290034-4b0mshqa.txt item: #377 of 672 id: cord-290120-fd26t8ja author: Tan, Chew Yee title: First molecular detection and complete sequence analysis of porcine circovirus type 3 (PCV3) in Peninsular Malaysia date: 2020-07-24 words: 6610 flesch: 48 summary: In the first cluster, Malaysian PCV3 strains were grouped with PCV3 strains from Italy (GenBank accession no.: [21] for a final identity confirmation as PCV3 by comparing their similarity with reference PCV3 sequences deposited in the GenBank. keywords: circovirus; detection; malaysia; orf2; pcv2; pcv3; pigs; porcine; samples; sequences; strains; study; type; values cache: cord-290120-fd26t8ja.txt plain text: cord-290120-fd26t8ja.txt item: #378 of 672 id: cord-290446-43h1r4pm author: Vazquez, Leonardo title: Comprehensive structural analysis of designed incomplete polypeptide chains of the replicase nonstructural protein 1 from the severe acute respiratory syndrome coronavirus date: 2017-07-27 words: 8864 flesch: 44 summary: Fluorescent molecule with exceptional binding properties Extrinsic Fluorescent Dyes as Tools for Protein Characterization Development of hydrophobicity parameters to analyze proteins which bear postor cotranslational modifications Initial hydrophobic collapse in the folding of barstar Structural characterization of proteins and complexes using small-angle Xray solution scattering Hydrodynamic Radii of Native and Denatured Proteins Measured by Pulse Field Gradient NMR Techniques † Internal motion in globular proteins The 13C Chemical-Shift Index: A simple method for the identification of protein secondary structure using 13C chemical-shift data The chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopy Sensitivity of secondary structure propensities to sequence differences between α-and γ-synuclein: Implications for fibrillation Chain Length Dependence of Apomyoglobin Folding: Structural Evolution from Misfolded Sheets to Native Helices † Backbone dynamics of proteins as studied by 15N inverse detected heteronuclear NMR spectroscopy: application to staphylococcal nuclease Rapid formation of secondary structure framework in protein folding studied by stopped-flow circular dichroism A Non-Native α-Helix Is Formed in the -Sheet Region of the Molten Globule State of Canine Milk Lysozyme Transient Non-Native Helix Formation during the Folding of b-Lactoglobulin Non-native alpha-helical intermediate in the refolding of beta-lactoglobulin, a predominantly beta-sheet protein Chain length dependence of apomyoglobin folding: structural evolution from misfolded sheets to native helices Transient folding intermediates characterized by protein engineering Truncated staphylococcal nuclease is compact but disordered Exploring the folding funnel of a polypeptide chain by biophysical studies on protein fragments The active form of the steroidogenic acute regulatory protein, StAR, appears to be a molten globule Novel β-barrel fold in the nuclear magnetic resonance structure of the replicase nonstructural protein 1 from the severe acute respiratory syndrome coronavirus The small-angle X-ray scattering beamline of the Brazilian Synchrotron Light Laboratory FIT2D: an introduction and overview. Parallels with the protein folding pathway A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding Quantitative determination of ribosome nascent chain stability Cotranslational Protein Folding inside the Ribosome Exit Tunnel Protein folding on the ribosome studied using NMR spectroscopy The Ribosome Modulates Nascent Protein Folding Transient Tertiary Structure Formation within the Ribosome Exit Port Tertiary interactions within the ribosomal exit tunnel Design of an expression system for detecting folded protein domains and mapping macromolecular interactions by NMR Fast folding of a prototypic polypeptide: The immunoglobulin binding domain of streptococcal protein G Mapping the Binding Site for Matrix Metalloproteinase on the N-Terminal Domain of the Tissue Inhibitor of Metalloproteinases-2 by NMR Chemical Shift Perturbation † Using chemical shift perturbation to characterise ligand binding Crystal structure of truncated human βB1-crystallin X-ray analysis of βB2-crystallin and evolution of oligomeric lens proteins The Use of Circular Dichroism in the Investigation of Protein Structure and Function Dimer formation from 1-anilino-8-naphthalenesulfonate catalyzed by bovine serum albumin. keywords: chemical; construct; domain; fig; folding; fusion; gb1; length; nsp1; nsp1(13; polypeptide; protein; strand; structure cache: cord-290446-43h1r4pm.txt plain text: cord-290446-43h1r4pm.txt item: #379 of 672 id: cord-290539-8ak2tths author: Cagno, Valeria title: Novel broad spectrum virucidal molecules against enveloped viruses date: 2018-12-07 words: 5556 flesch: 46 summary: Post treatment: Cells were infected with HSV-2 (MOI 0.01) for 2 h at 37˚C, the viral inoculum was removed and cultures were exposed to different compound concentrations and incubated until control cultures displayed extensive cytopathology. Virolytic antiviral peptides derived from mastoparan were shown to inhibit different enveloped viruses acting on the envelope and causing its detachment from the viral core [14] . keywords: acid; activity; assay; cells; compound; fig; hsv-2; mixture; virus; viruses cache: cord-290539-8ak2tths.txt plain text: cord-290539-8ak2tths.txt item: #380 of 672 id: cord-290773-kgb8r561 author: Ahn, Jong Gyun title: Clinical characteristics and cytokine profiles of children with acute lower respiratory tract infections caused by human rhinovirus date: 2018-07-03 words: 2597 flesch: 43 summary: Understanding the epidemiological, clinical, and immunological features of HRV will help to prevent and treat HRV respiratory diseases. Therefore, in this study, we investigated the epidemiological, clinical, and virological characteristics of HRV infections in children with acute lower respiratory tract infections. keywords: children; hrv; human; infections; rhinovirus; species cache: cord-290773-kgb8r561.txt plain text: cord-290773-kgb8r561.txt item: #381 of 672 id: cord-290833-m0wodqr3 author: Yuan, Lvfeng title: Synthetic surfactin analogues have improved anti-PEDV properties date: 2019-04-11 words: 3587 flesch: 47 summary: The SLPs were tested for anti-PEDV activity using a plaque reduction assay. In order to explore the relationship between CMC, anti-PEDV activity, and hemolytic activity, scatter plots for pairs of assays (Fig 5) . keywords: acid; activity; amino; cells; lipopeptides; pedv; slp5; surfactin; virus cache: cord-290833-m0wodqr3.txt plain text: cord-290833-m0wodqr3.txt item: #382 of 672 id: cord-291104-6chpmgry author: Leung, Danny T. M. title: Osteopontin Fragments with Intact Thrombin-Sensitive Site Circulate in Cervical Cancer Patients date: 2016-08-05 words: 6276 flesch: 49 summary: It is instructive that at the start of our study, we had actually experimented with pairs of mAbs (e.g. biotinylated-mAb 659 and -mAb 446) in capture ELI-SAs to detect plasma OPN from patients, but none had succeeded. Differences in the antibody pairs used can affect the type of OPN fragment detected and hence the vast discordances among test kits for the same set of plasma samples keywords: cancer; elisa; fig; fraction; kda; mab; opn; osteopontin; patients; plasma; protein cache: cord-291104-6chpmgry.txt plain text: cord-291104-6chpmgry.txt item: #383 of 672 id: cord-291176-evb6yt0r author: Giorgi Rossi, Paolo title: Characteristics and outcomes of a cohort of COVID-19 patients in the Province of Reggio Emilia, Italy date: 2020-08-27 words: 4569 flesch: 42 summary: key: cord-291176-evb6yt0r authors: Giorgi Rossi, Paolo; Marino, Massimiliano; Formisano, Debora; Venturelli, Francesco; Vicentini, Massimo; Grilli, Roberto title: Characteristics and outcomes of a cohort of COVID-19 patients in the Province of Reggio Emilia, Italy date: 2020-08-27 journal: PLoS One DOI: 10.1371/journal.pone.0238281 sha: doc_id: 291176 cord_uid: evb6yt0r This is a population-based prospective cohort study on archive data describing the age- and sex-specific prevalence of COVID-19 and its prognostic factors. The cohort of COVID-19 patients includes all symptomatic patients who tested positive with PCR between February 27 and April 2, 2020. keywords: age; covid-19; death; disease; hospitalization; patients; risk; study cache: cord-291176-evb6yt0r.txt plain text: cord-291176-evb6yt0r.txt item: #384 of 672 id: cord-291360-z19ri377 author: Lan, Fan-Yun title: COVID-19 symptoms predictive of healthcare workers’ SARS-CoV-2 PCR results date: 2020-06-26 words: 4357 flesch: 45 summary: Positive assay results represented detection of SARS--CoV2 RNA, while for negative results, the virus was not detected. Table 3 shows the counts and percentages of HCWs with positive and negative assays, and age-and sex-adjusted odds ratios for increasing numbers of total reported symptoms. keywords: assays; cov-2; covid-19; hcws; pcr; sars; symptoms cache: cord-291360-z19ri377.txt plain text: cord-291360-z19ri377.txt item: #385 of 672 id: cord-291417-p49ukyhx author: Mikulska, Malgorzata title: Tocilizumab and steroid treatment in patients with COVID-19 pneumonia date: 2020-08-20 words: 4449 flesch: 38 summary: Indeed, some real life experiences in COVID-19 patients showed that the use of antiinflammatory treatments might be beneficial [12] . The OW-weighted Cox proportional hazard regression model was used to calculate the adjusted hazard-ratio (HR OW ) of tocilizumab/methylprednisolone/SOC vs SOC patients. keywords: covid-19; days; failure; methylprednisolone; patients; pneumonia; soc; tocilizumab; treatment cache: cord-291417-p49ukyhx.txt plain text: cord-291417-p49ukyhx.txt item: #386 of 672 id: cord-291756-ejh1r8h4 author: Pérez-Fuentes, María del Carmen title: Threat of COVID-19 and emotional state during quarantine: Positive and negative affect as mediators in a cross-sectional study of the Spanish population date: 2020-06-25 words: 3769 flesch: 44 summary: There was a direct positive effect of perceived threat from COVID-19 on sadness-depression, anxiety and anger-hostility moods, while anxiety and anger-hostility had a direct positive effect on perception of threat from the virus. Thus, there was a circular relationship, in which perceived threat influenced the presence of negative mood, and negative mood, in turn, linked to emotions of irritation and agitation from a present situation, promoted the feeling of threat. keywords: affect; anxiety; balance; covid-19; mood; perception; state; threat cache: cord-291756-ejh1r8h4.txt plain text: cord-291756-ejh1r8h4.txt item: #387 of 672 id: cord-292237-45hi4iz2 author: Calvo-Pinilla, Eva title: Establishment of a Bluetongue Virus Infection Model in Mice that Are Deficient in the Alpha/Beta Interferon Receptor date: 2009-04-09 words: 4742 flesch: 48 summary: The permeability disorders of the vascular system described for ruminants [35] is reflected in the petecheias observed in spleen in BTV infected mice. I. Pathogenesis of bluetongue virus infection in mice Measles virus spread and pathogenesis in genetically modified mice Induction of interferon with bluetongue virus in various cells The pathogenesis of experimental bluetongue virus infection of calves Dynamics of viral spread in bluetongue virus infected calves Bluetongue virus: virology, pathogenesis and immunity Efficacy of ZULVACH 1 -inactivaded and adjuvanted vaccine against bluetongue virus serotype 1 A simple method of estimating fifty percent endpoints Bluetongue virus detection by two real-time RT-qPCRs targeting two different genomic segments We thank Fort Dodge Veterinaria SA for facilitating the BTV inactivated vaccine ZULVAC-BTV-4. keywords: animal; bluetongue; btv; btv-4; ifnar; infection; mice; model; virus cache: cord-292237-45hi4iz2.txt plain text: cord-292237-45hi4iz2.txt item: #388 of 672 id: cord-292396-8w06oc5i author: Leger, Thomas title: Low-dose chest CT for diagnosing and assessing the extent of lung involvement of SARS-CoV-2 pneumonia using a semi quantitative score date: 2020-11-03 words: 3388 flesch: 52 summary: In particular, lymph nodes and pleural effusion are highly frequent in severe patients. This type of CT score was first described in 2004 for severe acute respiratory syndrome (SARS). keywords: covid-19; involvement; ldct; lung; news; patients; score cache: cord-292396-8w06oc5i.txt plain text: cord-292396-8w06oc5i.txt item: #389 of 672 id: cord-292475-jrl1fowa author: Abry, Patrice title: Spatial and temporal regularization to estimate COVID-19 reproduction number R(t): Promoting piecewise smoothness via convex optimization date: 2020-08-20 words: 7472 flesch: 46 summary: The tool also provides local trends that permit to forecast short-term future values of R. The proposed tools were applied to pandemic incidence data consisting of daily counts of new infections, from several databases providing data either worldwide on an aggregated percountry basis or, for France only, based on the sole hospital counts, spread across the French territory. This calls for a triplet of constraints: i) robust access to fast-collected data; ii) semi-parametric models for such data that focus on a subset of critical parameters; iii) estimation procedures that are both elaborated enough to yield robust estimates, and versatile enough to be used on a daily basis and applied to (often-limited in quality and quantity) available data. keywords: data; estimation; ffi; france; number; pandemic; r(t; reproduction; time cache: cord-292475-jrl1fowa.txt plain text: cord-292475-jrl1fowa.txt item: #390 of 672 id: cord-292537-9ra4r6v6 author: Liu, Fenglin title: Predicting and analyzing the COVID-19 epidemic in China: Based on SEIRD, LSTM and GWR models date: 2020-08-27 words: 5675 flesch: 47 summary: Among them, the number of confirmed cases was the mostly used and reflected the severity of COVID-19 epidemic. The average percent error of LSTM model predictions for the four selected provinces and cities was within ±1.0% on February 14 th (Table 5) . keywords: cases; china; coronavirus; covid-19; data; epidemic; model; number; rate; study; wuhan cache: cord-292537-9ra4r6v6.txt plain text: cord-292537-9ra4r6v6.txt item: #391 of 672 id: cord-292777-oztmw8jo author: Wong, Michelle title: Microbial Translocation Contribute to Febrile Episodes in Adults with Chemotherapy-Induced Neutropenia date: 2013-07-16 words: 3303 flesch: 31 summary: sCD14 concentrations were however, elevated in febrile episodes (p = 0.0066) and no association was observed between sCD14 concentration and microbiological findings. Unusual presentations of infection in neutropenic patients Fever in immunocompromised patients Molecular diagnosis of sepsis in neutropenic patients with haematological malignancies Bacteremia and fungemia in patients with neoplastic disease Infections in patients with febrile neutropenia: epidemiology, microbiology, and risk stratification The Infectious Diseases Society of America 2002 guidelines for the use of antimicrobial agents in patients with cancer and neutropenia: salient features and comments Bacteraemia in febrile neutropenic cancer patients Viral findings in adult hematological patients with neutropenia Fever of unknown origin-reexamined and redefined Fever of unknown origin in adults: 40 years on Microbial translocation is a cause of systemic immune activation in chronic HIV infection Endotoxaemia and inflammatory mediators in febrile patients with haematological disease Endotoxaemia as a cause of fever in immunosuppressed patients Endotoxaemia, fever and clinical status in immunosuppressed patients: a preliminary study Bacterial translocation and gram-negative bacteremia in patients with hematological malignancies Multiplex real-time PCR for detection of respiratory tract infections Submitted) keywords: concentrations; endotoxin; episodes; findings; patients; scd14 cache: cord-292777-oztmw8jo.txt plain text: cord-292777-oztmw8jo.txt item: #392 of 672 id: cord-293072-giakcaki author: Xu, Wan-Xiang title: A simpler and more cost-effective peptide biosynthetic method using the truncated GST as carrier for epitope mapping date: 2017-10-12 words: 5335 flesch: 42 summary: Design all 16/18mer peptides with an overlap of 8 aa residues covering the full-length of the target protein or a longer segment sequence for the first round of antigenic peptide mapping, as well as design a set of 8mer peptides with overlapping 7 aa residues and covering each reactive 16/18mer peptide sequence for the second round of precise BCE motif identification. In order to know how many BCEs are there among three neighboring reactive 18mer-peptides of P32-34 (Fig 4A and 4B) , which were blotted in first round of antigenic peptide mapping in our study on epitome decoding of huZP4 protein, we first expressed a set of 8mer-peptides (P110-120) covering the full-length sequence of reactive P32 according to procedures of steps 1 to 8 in the protocol, and then they were subjected to SDS-PAGE, and transferred onto 0.2 μm nitrocellulose membrane. keywords: bce; bsp; clones; dna; gst188; mapping; method; motif; peptide; protein cache: cord-293072-giakcaki.txt plain text: cord-293072-giakcaki.txt item: #393 of 672 id: cord-293393-kbndie8e author: Braesch-Andersen, Sten title: ApoD Mediates Binding of HDL to LDL and to Growing T24 Carcinoma date: 2014-12-16 words: 6296 flesch: 52 summary: Anti-apoD antibodies capture ApoB in a detergent-free dual specific ELISA. Three flasks each of confluent cells (2.5 million in 9 ml) and non-confluent cells (1.5 million in 7 ml) were sampled 4 times. keywords: anti; apob; apod; apolipoprotein; binding; cells; confluent; elisa; hdl; ldl; particles cache: cord-293393-kbndie8e.txt plain text: cord-293393-kbndie8e.txt item: #394 of 672 id: cord-293794-vudufao5 author: Cuthbertson, Leah title: Viral respiratory infections and the oropharyngeal bacterial microbiota in acutely wheezing children date: 2019-10-17 words: 4823 flesch: 43 summary: It has been suggested this may be due to immune modulation by these organisms, in infants resulting in increased risk of asthma development in later life [13] . Using 16s rRNA gene sequencing of respiratory samples from children presenting to hospital with acute wheezing, this study aimed to examine whether the bacterial community in the airways of children with acute respiratory wheeze was altered compared with that of nonwheezing children. Significant differences in Shannon-Weiner and inverse Simpsons were observed in those that required oxygen and those that had ever attended kindergarten. keywords: analysis; cases; children; community; differences; diversity; samples; study; wheeze cache: cord-293794-vudufao5.txt plain text: cord-293794-vudufao5.txt item: #395 of 672 id: cord-293946-4bquxdqa author: Huong, Nguyen Quynh title: Coronavirus testing indicates transmission risk increases along wildlife supply chains for human consumption in Viet Nam, 2013-2014 date: 2020-08-10 words: 6230 flesch: 46 summary: [31] to explore phylogenetic relationships among bat coronavirus 512/2005 sequences at the intraspecies level, as haplotype networks may better represent the relationships among viral sequences with low sequence diversity compared with phylogenetic trees We observed two main clusters and a shallow geographic structure of genetic diversity, perhaps illustrative of sampling effort but also of localized transmission and circulation of bat coronavirus 512/2005 strains in these provinces. keywords: animals; bat; bats; coronavirus; farms; field; guano; human; nam; rats; rodents; samples; sites; species; trade; viet; wildlife cache: cord-293946-4bquxdqa.txt plain text: cord-293946-4bquxdqa.txt item: #396 of 672 id: cord-294023-knaxr7t0 author: Murri, Rita title: Social media as a tool for scientific updating at the time of COVID pandemic: Results from a national survey in Italy date: 2020-09-03 words: 2074 flesch: 46 summary: key: cord-294023-knaxr7t0 authors: Murri, Rita; Segala, Francesco Vladimiro; Del Vecchio, Pierluigi; Cingolani, Antonella; Taddei, Eleonora; Micheli, Giulia; Fantoni, Massimo title: Social media as a tool for scientific updating at the time of COVID pandemic: Results from a national survey in Italy date: 2020-09-03 journal: PLoS One DOI: 10.1371/journal.pone.0238414 sha: doc_id: 294023 cord_uid: knaxr7t0 In the face of the rapid evolution of the COVID-19 pandemic, healthcare professionals on the frontline are in urgent need of frequent updates in the accomplishment of their practice. 70% (n = 261) of respondents reported that their use of social media to seek medical information increased during the pandemic. keywords: covid-19; information; media; pandemic cache: cord-294023-knaxr7t0.txt plain text: cord-294023-knaxr7t0.txt item: #397 of 672 id: cord-294372-pec1886j author: Greene, Dina N. title: Decreasing median age of COVID-19 cases in the United States—Changing epidemiology or changing surveillance? date: 2020-10-15 words: 1700 flesch: 55 summary: key: cord-294372-pec1886j authors: Greene, Dina N.; Jackson, Michael L.; Hillyard, David R.; Delgado, Julio C.; Schmidt, Robert L. title: Decreasing median age of COVID-19 cases in the United States—Changing epidemiology or changing surveillance? date: 2020-10-15 journal: PLoS One DOI: 10.1371/journal.pone.0240783 sha: doc_id: 294372 cord_uid: pec1886j BACKGROUND: Given the striking increase in risk of severe COVD-19 with increasing age, our findings suggest that the increasing availability of SARS-CoV-2 tests has increased testing of low-acuity patients or asymptomatic persons in ambulatory care settings, who tend to be younger than the more severely ill patients. keywords: age; sars; years cache: cord-294372-pec1886j.txt plain text: cord-294372-pec1886j.txt item: #398 of 672 id: cord-294568-12eyo13f author: Fernandes-Matano, Larissa title: Prevalence of non-influenza respiratory viruses in acute respiratory infection cases in Mexico date: 2017-05-03 words: 4936 flesch: 41 summary: Real-Time RT-PCR Assay for Non-Influenza Respiratory Viruses Anuario de Morbilidad Lineamientos para la Vigilancia de Influenza por Laboratorio Viral coinfection in acute respiratory infection in Mexican children treated by the emergency service: A cross-sectional study The frequency and seasonality of influenza and other respiratory viruses in Tennessee: two influenza seasons of surveillance data Surveillance for severe acute respiratory infections in Southern Arizona Prevalence of respiratory virus in symptomatic children in private physician office settings in five communities of the state of Veracruz, Mexico Influenza and other respiratory virus infections in outpatients with medically attended acute respiratory infection during Human rhinovirus and disease severity in children Rhinovirus infection in children hospitalized with acute bronchiolitis and its impact on subsequent wheezing or asthma: a comparison of etiologies The role of rhinovirus in asthma exacerbations The ABCs of rhinoviruses, wheezing, and asthma Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production Pathogenesis of rhinovirus infection Frequency of viruses associated with acute respiratory infections in children younger than five years of age at a locality of Mexico City Comparative viral frequency in Mexican children under 5 years of age with and without upper respiratory symptoms According to data from the Secretary of Health, approximately 80% of the samples from patients with ARIs that are received for confirmation of influenza virus infection outside of flu season are negative for the different strains of this virus and remain without a defined aetiology. keywords: age; aris; cases; children; human; infections; influenza; prevalence; samples; study; viruses cache: cord-294568-12eyo13f.txt plain text: cord-294568-12eyo13f.txt item: #399 of 672 id: cord-294591-793ywpcd author: Hu, Xiaoyun title: Self-Reported Use of Personal Protective Equipment among Chinese Critical Care Clinicians during 2009 H1N1 Influenza Pandemic date: 2012-09-05 words: 3621 flesch: 35 summary: Vaccination status, positive attitudes towards PPE use, cultural factor (perceived reprimand for noncompliance), and organizational factors (availability of PPE in ICU, notice of influenza precautions) were identified as independent predictors of high compliance, while negative attitudes towards PPE use and violation of recommended PPE use were associated with low compliance. Similar to the study of Daugherty and coworkers [16] , we found a similar proportion (74%) of respondents claiming their confidence to improve compliance to PPE use, again suggesting perception of inadequate PPE use among most respondents. keywords: care; compliance; influenza; knowledge; pandemic; ppe; use cache: cord-294591-793ywpcd.txt plain text: cord-294591-793ywpcd.txt item: #400 of 672 id: cord-294592-zwvr57a0 author: Mukherjee, Moumita title: Global cataloguing of variations in untranslated regions of viral genome and prediction of key host RNA binding protein-microRNA interactions modulating genome stability in SARS-CoV-2 date: 2020-08-11 words: 6103 flesch: 48 summary: We have also looked at the possible regulation of viral genomic RNA through binding of host RNA binding proteins (RBPs) and miR-NAs in specific sequences of the viral UTRs. We also looked at the putative host RNA binding protein (RBP) and microRNA binding sites in these regions by ‘RBPmap’ and ‘RNA22 v2’ respectively. keywords: binding; expression; genome; host; mirna; region; rna; sars; sequence; site; variants; virus cache: cord-294592-zwvr57a0.txt plain text: cord-294592-zwvr57a0.txt item: #401 of 672 id: cord-294645-yzh8h7zo author: Freeman, David W. title: Association between GDF15, poverty and mortality in urban middle-aged African American and white adults date: 2020-08-07 words: 4988 flesch: 41 summary: It is also important to understand how temporal changes in GDF15 levels vis-à-vis socioeconomic measures relate with mortality risk and aging-related diseases in disadvantaged communities and to assess interaction between changes in GDF15 and the social determinants of health. There is limited information about whether poverty influences biologic markers of mortality risk. keywords: cause; gdf15; health; interaction; loggdf15; mortality; poverty; race; risk; status; study cache: cord-294645-yzh8h7zo.txt plain text: cord-294645-yzh8h7zo.txt item: #402 of 672 id: cord-294768-bs6thjw2 author: Alonso-Fernández, Alberto title: Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study date: 2020-08-25 words: 4656 flesch: 43 summary: D-dimer, platelet count, and, C reactive protein values were significantly higher among PE patients. The proportion of patients with PE diagnosed during the first days (when laboratory data was obtained by protocol) was higher (66.7%) than the proportion of PE patients diagnosed during follow-up (when laboratory data was obtained at the discretion of the clinician) (42.9%). keywords: covid-19; dimer; patients; pneumonia; pulmonary; risk; study; values cache: cord-294768-bs6thjw2.txt plain text: cord-294768-bs6thjw2.txt item: #403 of 672 id: cord-294912-xl0wzi16 author: Alteri, Claudia title: Detection and quantification of SARS-CoV-2 by droplet digital PCR in real-time PCR negative nasopharyngeal swabs from suspected COVID-19 patients date: 2020-09-08 words: 3634 flesch: 38 summary: Of note, a severe COVID-19 manifestation characterized 14 of the 19 patients with a ddPCR confirmed SARS--CoV-2 infection (73.7%, S1 Table) . In order to further confirm the performance of the ddPCR-based assay, IgG against SARS--CoV-2 were tested by using a commercial Chemiluminescent microparticle immunoassay IgG against SARS-CoV-2 (https://www.corelaboratory.abbott/us/en/offerings/segments/ infectious-disease/sars-cov-2, sensitivity:99.9% specificity:100%) keywords: copies; cov-2; covid-19; ddpcr; patients; rtpcr; samples; sars cache: cord-294912-xl0wzi16.txt plain text: cord-294912-xl0wzi16.txt item: #404 of 672 id: cord-295201-u2dola34 author: Morimoto, Konosuke title: The Burden and Etiology of Community-Onset Pneumonia in the Aging Japanese Population: A Multicenter Prospective Study date: 2015-03-30 words: 5400 flesch: 41 summary: The proportion of pneumonia cases among outpatients in hospitals (α ij1 ) was calculated from the surveillance data. To estimate the proportion of pneumonia cases among outpatients in clinics (α ij2 ), we obtained the clinic databases from two clinics in Nagasaki City. keywords: age; aspiration; burden; cases; community; incidence; japan; patients; pneumonia; population; study; years cache: cord-295201-u2dola34.txt plain text: cord-295201-u2dola34.txt item: #405 of 672 id: cord-295293-ickp2n47 author: Latsuzbaia, Ardashel title: Evolving social contact patterns during the COVID-19 crisis in Luxembourg date: 2020-08-06 words: 2977 flesch: 47 summary: Another limitation of our study is that the pre-pandemic survey conducted in 2007 was conducted using a paper diary approach and our online approach might lead to lower ascertainment of contact numbers. While the number of social contacts was substantially lower during the lockdown by more than 80% compared to the pre-pandemic period, we observed a more recent 121% increase during the post lockdown period showing an increased potential for COVID-19 spread. keywords: contacts; iqr; lockdown; mean; number cache: cord-295293-ickp2n47.txt plain text: cord-295293-ickp2n47.txt item: #406 of 672 id: cord-295339-nzc47itk author: Baker, Marissa G. title: Estimating the burden of United States workers exposed to infection or disease: A key factor in containing risk of COVID-19 infection date: 2020-04-28 words: 3322 flesch: 34 summary: While the majority of exposed workers are employed in healthcare sectors, other occupational sectors also have high proportions of exposed workers. While the majority of exposed workers are employed in healthcare sectors, other occupational sectors also have high proportions of exposed workers. keywords: disease; exposure; infection; occupations; states; workers; workplace cache: cord-295339-nzc47itk.txt plain text: cord-295339-nzc47itk.txt item: #407 of 672 id: cord-295352-b8kztgt8 author: Maksimowski, Nicholas title: Kidney ACE2 expression: Implications for chronic kidney disease date: 2020-10-30 words: 3520 flesch: 47 summary: In addition, loss of ACE2 accelerates the progression of experimental kidney disease [35-37]; therefore, we also studied the relationships between kidney ACE2 expression and genes implicated in inflammation and fibrosis in CKD. Important clinical data regarding ethnicity and race, and treatment with ACEIs and/or ARBs were not available, so we could not address the impact of these variables on kidney ACE2 expression in our study. keywords: ace2; ckd; expression; fig; kidney; mrna cache: cord-295352-b8kztgt8.txt plain text: cord-295352-b8kztgt8.txt item: #408 of 672 id: cord-295536-dbpt4dhr author: Shook, Natalie J. title: Disease avoidance in the time of COVID-19: The behavioral immune system is associated with concern and preventative health behaviors date: 2020-08-20 words: 4605 flesch: 36 summary: Identifying psychological factors that may encourage engagement in preventative health behaviors is crucial. Germ aversion and pathogen disgust sensitivity were the two variables most consistently associated with COVID-19 concern and preventative health behaviors, while accounting for demographic, health, and psychosocial covariates. keywords: behaviors; concern; covid-19; disease; disgust; health; participants cache: cord-295536-dbpt4dhr.txt plain text: cord-295536-dbpt4dhr.txt item: #409 of 672 id: cord-295559-yc8q62z8 author: Qian, Zhaohui title: Role of the Spike Glycoprotein of Human Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Virus Entry and Syncytia Formation date: 2013-10-03 words: 7314 flesch: 44 summary: We have used lentivirus pseudotypes with MERS-CoV spike glycoprotein to identify cells susceptible to infection with MERS-CoV and to study the role of MERS S protein in virus entry and syncytia formation. Thus, MERS S protein does not require acidification to mediate virus entry, and the acidification required for endosomal entry keywords: cells; coronavirus; cov; entry; figure; human; membrane; mers; protein; pseudovirions; receptor; spike; vero cache: cord-295559-yc8q62z8.txt plain text: cord-295559-yc8q62z8.txt item: #410 of 672 id: cord-295781-b831y105 author: VanLeuven, James T. title: Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory viruses date: 2017-06-02 words: 7225 flesch: 47 summary: Interestingly, the differences in kinetics of host cell gene expression did not correspond with differences in the kinetics of viral replication in this cell line (S1 Fig). Current protocols in microbiology Enhanced growth of a murine coronavirus in transformed mouse cells Substrate-specific gene expression in Batrachochytrium dendrobatidis, the chytrid pathogen of amphibians A framework for oligonucleotide microarray preprocessing Controlling the False Discovery Rate-a Practical and Powerful Approach to Multiple Testing Interferome v2.0: an updated database of annotated interferon-regulated genes Rhinovirus induces airway epithelial gene expression through double-stranded RNA and IFN-dependent pathways Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infection A systems approach to understanding human rhinovirus and influenza virus infection Gene expression profiles during in vivo human rhinovirus infection: insights into the host response Plasticity and virus specificity of the airway epithelial cell immune response during respiratory virus infection Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses Innate immune response to influenza A virus in differentiated human alveolar type II cells Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro Alveolar Type II Epithelial Cells Contribute to the Anti-Influenza A Virus Response in the Lung by Integrating Pathogenand Microenvironment-Derived Signals Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia Development of a mouse model mimicking key aspects of a viral asthma exacerbation Experimental rhinovirus infection increases human tissue kallikrein activation in allergic subjects Kinins are generated during experimental rhinovirus colds Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-kappaB and EGFR pathways Localization of mouse hepatitis virus nonstructural proteins and RNA synthesis indicates a role for late endosomes in viral replication Mouse hepatitis virus replicase proteins associate with two distinct populations of intracellular membranes Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5 Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome T cell epitope specificity and pathogenesis of mouse hepatitis virus-1-induced disease in susceptible and resistant hosts Characterization of the murine alpha interferon gene family Regulation of inducible and tissue-specific gene expression. keywords: cells; expression; fig; genes; ifn; infection; mhv; pr8; response; type; viruses cache: cord-295781-b831y105.txt plain text: cord-295781-b831y105.txt item: #411 of 672 id: cord-296399-vvbjulm9 author: Brinkmann, Constantin title: The glycoprotein of vesicular stomatitis virus promotes release of virus-like particles from tetherin-positive cells date: 2017-12-07 words: 7023 flesch: 38 summary: These observations could indicate that VSV-G-mediated tetherin antagonism is not operative in VSV infected cells. Moreover, siRNAmediated knock-down of endogenous tetherin expression in HeLa cells reduced the amount of cell surface associated tetherin (Fig 3B) and increased viral titers roughly 10-fold as compared to cells transfected with scrambled siRNA or mock transfected cells (Fig 3C) . keywords: antagonism; cells; ebov; expression; fig; medium; protein; release; spread; tetherin; virus; vpu; vsv cache: cord-296399-vvbjulm9.txt plain text: cord-296399-vvbjulm9.txt item: #412 of 672 id: cord-296435-6dergkha author: Wang, Tiehua title: Thrombocytopenia Is Associated with Acute Respiratory Distress Syndrome Mortality: An International Study date: 2014-04-14 words: 4479 flesch: 34 summary: Although not significant, ARDS patients were in the ICU longer (ARDS median = 13 days; non-ARDS median = 9 days; p = 0.21) and on mechanical ventilation longer (ARDS median = 7 days; non-ARDS median = 5 days;p = 0.53) than non-ARDS patients. In contrast, pneumonia (p = 0.002) and external pulmonary injury (p = 0.013) had higher mortality rates in non-ARDS patients. keywords: ards; beijing; boston; cohort; icu; mortality; patients; risk; thrombocytopenia cache: cord-296435-6dergkha.txt plain text: cord-296435-6dergkha.txt item: #413 of 672 id: cord-296487-m4xba78g author: MacIntyre, Chandini Raina title: Health system capacity in Sydney, Australia in the event of a biological attack with smallpox date: 2019-06-14 words: 5064 flesch: 49 summary: Physical space requirements extend beyond isolation of smallpox cases, to quarantine of contacts. Today, work health and safety requirements would dictate that PAPRs or disposable respirators with a hood and coveralls be available to clinicians treating smallpox cases. keywords: beds; case; contacts; epidemic; health; number; response; smallpox; tracing cache: cord-296487-m4xba78g.txt plain text: cord-296487-m4xba78g.txt item: #414 of 672 id: cord-296550-wkmnfph3 author: Hossain, Mohammad Anwar title: Knowledge, attitudes, and fear of COVID-19 during the Rapid Rise Period in Bangladesh date: 2020-09-24 words: 4581 flesch: 51 summary: However, our study did find subjects with high fear scores and who were also more likely to follow good preventive practices, as recommended by the health advisory. The majority of the population had high fear scores, with significantly higher scores found in women and elderly adults. keywords: bangladesh; covid-19; fear; knowledge; scores; study; subjects; symptoms cache: cord-296550-wkmnfph3.txt plain text: cord-296550-wkmnfph3.txt item: #415 of 672 id: cord-296635-8r3tm966 author: Breed, Andrew C. title: Evidence of Endemic Hendra Virus Infection in Flying-Foxes (Pteropus conspicillatus)—Implications for Disease Risk Management date: 2011-12-14 words: 4577 flesch: 43 summary: Vector Borne Zoonotic Diseases The ecology of Hendra virus and Australian bat lyssavirus Reproduction and nutritional stress are risk factors for Hendra virus infection in little red flying foxes (Pteropus scapulatus) Experimental Hendra virus infection in pregnant guinea-pigs and fruit bats (Pteropus poliocephalus) Isolation of Hendra virus from pteropid bats: a natural reservoir of Hendra virus Fenner's Veterinary Virology Landscape-scale redistribution of a highly mobile threatened species, Pteropus conspicillatus (Chiroptera, Pteropodidae), in response to Tropical Cyclone Larry Volant viruses: a concern to bats, humans and other animals Spatial and Temporal Patterns of Zaire ebolavirus Antibody Prevalence in the Possible Reservoir Bat Species Amplification of emerging viruses in a bat colony Ecology of rabies virus exposure in colonies of Brazilian free-tailed bats (Tadarida brasiliensis) at natural and man-made roosts in Texas Flying foxes: fruit and blossom bats of Australia Latitudinal range shifts in Australian flying-foxes: A re-evaluation Evidence for Nipah virus recrudescence and serological patterns of captive Pteropus vampyrus Fatal encephalitis due to novel paramyxovirus transmitted from horses Relapsed and late-onset Nipah encephalitis Dietary variation in spectacled flying foxes (Pteropus conspicillatus) of the Australian Wet Tropics Field anaesthesia of three Australian species of flying fox Some aspects of female reproduction in the greyheaded flying-fox, Pteropus poliocephalus (Megachiroptera: Pteropodidae) Laboratory diagnosis of Nipah and Hendra virus infections Hendra and Nipah virus diseases. doi:10.1371/journal.pone.0028816.g003 The natural history of Hendra and Nipah viruses Nipah virus: impact, origins, and causes of emergence Evidence of henipavirus infection in West African fruit bats Henipavirus RNA in African bats Epidemiological perspectives on Hendra virus infection in horses and flying foxes Hendra virus outbreak with novel clinical features Queensland Government, Department of Primary Industries and Fisheries Hendra virus infection in a veterinarian Human Hendra virus encephalitis associated with equine outbreak Nipah virus: keywords: bats; females; flying; hendra; hev; infection; lactation; seroprevalence; transmission; virus cache: cord-296635-8r3tm966.txt plain text: cord-296635-8r3tm966.txt item: #416 of 672 id: cord-296691-cg463fbn author: Wang, Ren title: De novo Sequence Assembly and Characterization of Lycoris aurea Transcriptome Using GS FLX Titanium Platform of 454 Pyrosequencing date: 2013-04-09 words: 5838 flesch: 41 summary: Hence, determination of the genetic pathways and specific genes involved in Amaryllidaceae alkaloids biosynthesis and some other aspects of Lycoris could be beneficial for humans and enrich our knowledge and understanding of functional genomics and biological research. For the purpose of improving mRNA abundance of genes related to Amaryllidaceae alkaloids biosynthesis, the leaves were treated with those abiotic elicitors for RNA extraction. keywords: alkaloids; amaryllidaceae; analysis; aurea; biosynthesis; cdna; galanthamine; genes; lycoris; molecular; sequences; sequencing; species; total; transcriptome cache: cord-296691-cg463fbn.txt plain text: cord-296691-cg463fbn.txt item: #417 of 672 id: cord-297287-0i4nc353 author: Braun, Benjamin title: Simulating phase transitions and control measures for network epidemics caused by infections with presymptomatic, asymptomatic, and symptomatic stages date: 2020-09-10 words: 4005 flesch: 44 summary: Social distancing controls in this model exhibit a phase transition regarding total number of infections, either when imposed globally or when based on individual response to infected contacts. Reduced viral shedding with social distancing probability over 25% led to overall infection of approximately 2% of the agents. keywords: agent; control; distancing; model; number; shedding cache: cord-297287-0i4nc353.txt plain text: cord-297287-0i4nc353.txt item: #418 of 672 id: cord-297835-ukrz8tlv author: Leith, Douglas J. title: Measurement-based evaluation of Google/Apple Exposure Notification API for proximity detection in a light-rail tram date: 2020-09-30 words: 5592 flesch: 53 summary: Following [9] updated to reflect GAEN calibration changes pushed by Google on 13th June 2020, for the Google Pixel 2 handsets used in our experiments we map from RSSI to attenuation level using the formula -31-(RSSI-6) This is similar to the behaviour observed in previous GAEN measurements taken on a bus [8] , and is of course pertinent to the use of attenuation level as a proxy for distance. keywords: api; app; attenuation; detection; exposure; gaen; gaen api; handsets; level cache: cord-297835-ukrz8tlv.txt plain text: cord-297835-ukrz8tlv.txt item: #419 of 672 id: cord-298078-uqrwq5qk author: Kwak, Hoyun title: Annexin A2 Binds RNA and Reduces the Frameshifting Efficiency of Infectious Bronchitis Virus date: 2011-08-30 words: 5377 flesch: 51 summary: Since the frameshifting of IBV generates RNA dependent RNA polymerase, which is critical for successful viral replication, the protein that inhibits frameshifting must be a major antiviral regulator in eukaryotic cells. Since translation is a complex process involving many regulatory factors in addition to the ribosome, binding of RNA binding protein (RBP) at a nearby RNA signal could affect RNA conformation and somehow redirect the translational machinery keywords: anxa2; binding; cells; efficiency; frameshifting; ibv; mutant; protein; pseudoknot; ribosomal; rna; type cache: cord-298078-uqrwq5qk.txt plain text: cord-298078-uqrwq5qk.txt item: #420 of 672 id: cord-298131-zolwjl9u author: Xiao, Shuqi title: Understanding PRRSV Infection in Porcine Lung Based on Genome-Wide Transcriptome Response Identified by Deep Sequencing date: 2010-06-29 words: 9366 flesch: 34 summary: Data were presented as fold changes in gene expression normalized to the HPRT1 gene and relative to the C sample. Despite such limitations, our DGE study offers a broad, system-wide window into molecular processes that regulate gene expression and also provides new leads for functional studies of candidate genes involved in host-virus interaction, as illustrated in this paper. keywords: abundance; analysis; cells; expression; figure; genes; host; infected; infection; lungs; number; pigs; porcine; prrsv; response; syndrome; tags; transcript; viral; virus cache: cord-298131-zolwjl9u.txt plain text: cord-298131-zolwjl9u.txt item: #421 of 672 id: cord-298679-w0yp4u19 author: Iftimie, Simona title: Risk factors associated with mortality in hospitalized patients with SARS-CoV-2 infection. A prospective, longitudinal, unicenter study in Reus, Spain date: 2020-09-03 words: 3589 flesch: 42 summary: Wuhan studies report that the incidence of cancer is higher in COVID-19 patients than in the general population [34, 35] . One aspect that caught our attention is that, despite our hospital being the reference center for Oncology in our province, the number of cancer patients infected with COVID-19 was relatively low. keywords: coronavirus; cov-2; covid-19; disease; mortality; patients; sars; study cache: cord-298679-w0yp4u19.txt plain text: cord-298679-w0yp4u19.txt item: #422 of 672 id: cord-299491-8rfm0jxh author: Xiao, Shenglan title: Role of fomites in SARS transmission during the largest hospital outbreak in Hong Kong date: 2017-07-20 words: 4768 flesch: 50 summary: Birkhäuser Advances in Infectious Diseases BAID Evidence of airborne transmission of the severe acute respiratory syndrome virus Role of air distribution in SARS transmission during the largest nosocomial outbreak in Hong Kong Multi-zone modeling of probable SARS virus transmission by airflow between flats in Block E Severe acute respiratory syndrome coronavirus on hospital surfaces Detection of airborne severe acute respiratory syndrome (SARS) coronavirus and environmental contamination in SARS outbreak units Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice Effectiveness of precautions against droplets and contact in prevention of nosocomial transmission of severe acute respiratory syndrome (SARS). Except for Pattern 1, the long-range airborne route was predominant, which is consistent with several findings of the similarity between bio-aerosol concentrations and reported attack rates distributions in SARS outbreaks keywords: fig; file; fomite; infection; risk; route; sars; transmission cache: cord-299491-8rfm0jxh.txt plain text: cord-299491-8rfm0jxh.txt item: #423 of 672 id: cord-299509-7xjdryoq author: Scholte, Florine E. M. title: Characterization of Synthetic Chikungunya Viruses Based on the Consensus Sequence of Recent E1-226V Isolates date: 2013-08-01 words: 9731 flesch: 44 summary: To examine CHIKV-induced translational shut-off, the synthesis of 35 S-labeled viral and cellular proteins during the course of CHIKV LS3 infection was analyzed by metabolic labeling of infected 293/ACE2 cells with 35 S-Met and 35 S-Cys (Fig. 3C) . CHIKV RNA was isolated from virions using the QIAamp Viral RNA mini kit. keywords: cells; chikungunya; chikv; chikv ls3; fig; gfp; host; infection; ita07; ls3; p.i; ra1; replication; rna; sequence; strains; synthetic; vero; virus; viruses cache: cord-299509-7xjdryoq.txt plain text: cord-299509-7xjdryoq.txt item: #424 of 672 id: cord-299852-t0mqe7yy author: Janssen, Loes H. C. title: Does the COVID-19 pandemic impact parents’ and adolescents’ well-being? An EMA-study on daily affect and parenting date: 2020-10-16 words: 8586 flesch: 46 summary: We tested whether adding parent level (Level 2) to Model 1 for adolescents improved the model fit based on the likelihood ratio tests. Parents and adolescents who agreed to participate were sent an online questionnaire on demographic characteristics and general mental well-being. keywords: adolescents; affect; baseline; covid-19; covid-19 pandemic; model; pandemic; parenting; parents cache: cord-299852-t0mqe7yy.txt plain text: cord-299852-t0mqe7yy.txt item: #425 of 672 id: cord-299953-sasfvcun author: Whitehead, Ashley B. R. title: Burden of exposure to infectious bursal disease virus, infectious bronchitis virus, Newcastle disease virus, Mycoplasma gallisepticum, and intestinal parasites in introduced broiler chickens on the Galapagos date: 2018-09-24 words: 4447 flesch: 52 summary: Study results are relevant because (i) they provide new baseline data on the burden of exposure to avian pathogens in broiler farms, (ii) justify the need to verify standard operating procedures in hatcheries that supply (non-vaccinated) day-old chicks to the Galapagos and (iii) to implement enhanced biosecurity standards on broiler chicken farms to mitigate risk of disease transmission between broilers, backyard poultry, and wild birds on the Galapagos. Study results are relevant because (i) they provide new baseline data on the burden of exposure to avian pathogens in broiler farms, (ii) justify the Table 2 need to verify standard operating procedures in hatcheries that supply (non-vaccinated) dayold chicks to the Galapagos and (iii) to implement enhanced biosecurity standards on broiler chicken farms to mitigate risk of disease transmission between broilers, backyard poultry, and wild birds on the Galapagos. keywords: broilers; chickens; cristobal; cruz; exposure; farms; galapagos; santa; study cache: cord-299953-sasfvcun.txt plain text: cord-299953-sasfvcun.txt item: #426 of 672 id: cord-300859-nqklx0vn author: Henderson, Kelley C. title: Specificity and Strain-Typing Capabilities of Nanorod Array-Surface Enhanced Raman Spectroscopy for Mycoplasma pneumoniae Detection date: 2015-06-29 words: 8233 flesch: 37 summary: Unsupervised chemometric analysis of M. pneumoniae strain types and Mollicutes species An area of growing interest is the role of M. pneumoniae strain type in pathogenesis and disease epidemiology. keywords: clinical; control; detection; isolates; model; pls; pneumoniae; sers; species; spectra; strains; type cache: cord-300859-nqklx0vn.txt plain text: cord-300859-nqklx0vn.txt item: #427 of 672 id: cord-301180-ndiwmnv0 author: Lin, Min-Hsuan title: Nullbasic, a Potent Anti-HIV Tat Mutant, Induces CRM1-Dependent Disruption of HIV Rev Trafficking date: 2012-12-10 words: 5176 flesch: 31 summary: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling Intracellular trafficking and interactions of the HIV-1 Tat protein The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin betadependent nuclear localization signals Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1 Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import NOPdb: Nucleolar Proteome Database-2008 update Involvement of the nucleolus in replication of human viruses Involvement of the plant nucleolus in virus and viroid infections: parallels with animal pathosystems Protein B23 is an important human factor for the nucleolar localization of the human immunodeficiency virus protein Tat C23 interacts with B23, a putative nucleolar-localization-signal-binding protein Major nucleolar proteins shuttle between nucleus and cytoplasm The roles of nucleolar structure and function in the subcellular location of the HIV-1 Rev protein Recruitment of the Crm1 nuclear export factor is sufficient to induce cytoplasmic expression of incompletely spliced human immunodeficiency virus key: cord-301180-ndiwmnv0 authors: Lin, Min-Hsuan; Sivakumaran, Haran; Apolloni, Ann; Wei, Ting; Jans, David A.; Harrich, David title: Nullbasic, a Potent Anti-HIV Tat Mutant, Induces CRM1-Dependent Disruption of HIV Rev Trafficking date: 2012-12-10 journal: PLoS One DOI: 10.1371/journal.pone.0051466 sha: doc_id: 301180 cord_uid: ndiwmnv0 Nullbasic, a mutant of the HIV-1 Tat protein, has anti-HIV-1 activity through mechanisms that include inhibition of Rev function and redistribution of the HIV-1 Rev protein from the nucleolus to the nucleoplasm and cytoplasm. keywords: b23; cells; crm1; fig; myc; nuclear; nullbasic; proteins; rev; tat cache: cord-301180-ndiwmnv0.txt plain text: cord-301180-ndiwmnv0.txt item: #428 of 672 id: cord-301811-ykpiorgo author: Tanaka, Takuma title: Estimation of the percentages of undiagnosed patients of the novel coronavirus (SARS-CoV-2) infection in Hokkaido, Japan by using birth-death process with recursive full tracing date: 2020-10-28 words: 5533 flesch: 53 summary: If the individuals who came into contact with diagnosed patients had been so intensively tested that a much larger number of asymptomatic patients had been diagnosed, the analysis would have needed an extended model including asymptomatic diagnosed patients. Moreover, our model cannot utilize information on asymptomatic diagnosed patients. keywords: asymptomatic; contact; individuals; model; number; patients; tracing cache: cord-301811-ykpiorgo.txt plain text: cord-301811-ykpiorgo.txt item: #429 of 672 id: cord-302189-3xab3yxc author: Tillmann, Ramona Liza title: Sensitive Commercial NASBA Assay for the Detection of Respiratory Syncytial Virus in Clinical Specimen date: 2007-12-26 words: 1778 flesch: 35 summary: Hospitalized children with respiratory syncytial virus infection and neuromuscular impairment face an increased risk of a complicated course Human metapneumovirus infections cause similar symptoms and clinical severity as respiratory syncytial virus infections Viral etiology of acute respiratory tract infections in children presenting to hospital: role of polymerase chain reaction and demonstration of multiple infections Bronchiolitis: assessment and evidence-based management Community-acquired pneumonia in children Selected populations at increased risk from respiratory syncytial virus infection Respiratory syncytial virus infections in the pediatric intensive care unit: clinical characteristics and risk factors for adverse outcomes Palivizumab prophylaxis reduces hospitalization due to respiratory syncytial virus in young children with hemodynamically significant congenital heart disease Prospective population-based study of viral lower respiratory tract infections in children under 3 years of age (the PRI.DE study) Therefore, the FDA cleared CE marked NOW® RSV ELISA, the NucliSENS® EasyQ RSV A+B NASBA, and a literature based inhouse RT-PCR protocol were compared for their relative sensitivities. keywords: elisa; pcr; rsv cache: cord-302189-3xab3yxc.txt plain text: cord-302189-3xab3yxc.txt item: #430 of 672 id: cord-302200-9gekjgr0 author: Kilich, Eliz title: Factors that influence vaccination decision-making among pregnant women: A systematic review and meta-analysis date: 2020-07-09 words: 6662 flesch: 32 summary: Health Care for Women International Vulnerable groups within a vulnerable population: awareness of the A(H1N1)pdm09 pandemic and willingness to be vaccinated among pregnant women in Ivory Coast Poor uptake of influenza vaccination in pregnancy in northern India Disparities in Tdap vaccination and vaccine information needs among pregnant women in the United States Knowledge, attitudes, beliefs, and behaviors of pregnant women approached to participate in a Tdap maternal immunization randomized, controlled trial Missed opportunities for tetanus immunization of pregnant women in Juiz de Fora Knowledge, attitudes, beliefs, and barriers associated with the uptake of influenza vaccine among pregnant women Improving influenza vaccination coverage in pregnancy in Melbourne Increasing uptake of influenza vaccine by pregnant women post H1N1 pandemic: a longitudinal study in Antenatal vaccination against Group B streptococcus: attitudes of pregnant women and healthcare professionals in the UK towards participation in clinical trials and routine implementation An assessment of missed opportunities for immunization in children and pregnant women attending different health facilities of a state hospital Seasonal influenza vaccination in pregnant women: knowledge, attitudes, and behaviors in Italy Status of pandemic influenza vaccination and factors affecting it in Turkish pregnant women The perspective of pregnant women on pandemic influenza vaccine before pandemics Trends in seasonal influenza vaccine uptake during pregnancy in Western Australia: Implications for midwives Pregnant women's perception of risk with use of the H1N1 vaccine Influenza vaccination among pregnant women: Patient beliefs and medical provider practices Patient attitudes toward influenza and tetanus, diphtheria and acellular pertussis vaccination in pregnancy Vaccination of pregnant women in the Valencian community during the 2014-15 influenza season: A multicentre study Exploring patients' awareness and healthcare professionals' knowledge and attitude to pertussis and influenza vaccination during the antenatal periods in Cavan Monaghan general hospital Pandemic (H1N1) 2009 influenza vaccine uptake in pregnant women entering the 2010 influenza season in Western Australia Influenza and pertussis vaccination in pregnancy: Release 15 Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement Knowledge, attitudes and practices about influenza vaccination among pregnant women and healthcare providers serving pregnant women in Managua Understanding pregnant women's attitudes and behavior toward influenza and pertussis vaccination Vaccination against pertussis and influenza in pregnancy: A qualitative study of barriers and facilitators Perceptions of Hong Kong Chinese women toward influenza vaccination during pregnancy Increased awareness and health care provider endorsement is required to encourage pregnant women to be vaccinated Exploring pregnant women's views on influenza vaccination and educational text messages Message framing strategies to increase influenza immunization uptake among pregnant African American women Identifying ways to increase seasonal influenza vaccine uptake among pregnant women in China: A qualitative investigation of pregnant women and their obstetricians Reasons why pregnant women did not vaccinate against Influenza A H1N1 Attitudes and beliefs of pregnant women and new mothers regarding influenza vaccination in British Columbia Assessing the acceptability of a maternal Tdap vaccine based on mothers' knowledge, attitudes, and beliefs of pertussis and vaccinations in Lusaka, Zambia. keywords: analysis; factors; influenza; maternal; pandemic; pertussis; pregnancy; studies; uptake; vaccination; vaccine; women cache: cord-302200-9gekjgr0.txt plain text: cord-302200-9gekjgr0.txt item: #431 of 672 id: cord-302355-3se1wp8o author: Chen, Yi-Shiuan title: The conserved stem-loop II structure at the 3' untranslated region of Japanese encephalitis virus genome is required for the formation of subgenomic flaviviral RNA date: 2018-07-26 words: 6032 flesch: 45 summary: Furthermore, being infected with RNA viruses induces double membrane vesicles to form replication/transcription complexes that are protease-and nuclease-resistant [27] [28] [29] . The DENV sfRNA is readily formed when treated with XRN1 at concentration as low as 0.01 units (Fig 1E, lane 7) , whereas the 800-nt JEV RNA was relatively resistant to low concentrations of XRN1 (0.01 and 0.1 unit) (Fig 1E, lanes 2 and 3) . keywords: accumulation; cells; fig; formation; genome; jev; rdrp; replication; sfrna; structure; virus; vitro; xrn1 cache: cord-302355-3se1wp8o.txt plain text: cord-302355-3se1wp8o.txt item: #432 of 672 id: cord-302529-43pd2qsp author: El Moussi, Awatef title: Virological Surveillance of Influenza Viruses during the 2008–09, 2009–10 and 2010–11 Seasons in Tunisia date: 2013-09-19 words: 3251 flesch: 39 summary: key: cord-302529-43pd2qsp authors: El Moussi, Awatef; Pozo, Francisco; Ben Hadj Kacem, Mohamed Ali; Ledesma, Juan; Cuevas, Maria Teresa; Casas, Inmaculada; Slim, Amine title: Virological Surveillance of Influenza Viruses during the 2008–09, 2009–10 and 2010–11 Seasons in Tunisia date: 2013-09-19 journal: PLoS One DOI: 10.1371/journal.pone.0074064 sha: doc_id: 302529 cord_uid: 43pd2qsp BACKGROUND: The data contribute to a better understanding of the circulation of influenza viruses especially in North-Africa. We describe in this report the findings of laboratory-based surveillance of human cases of influenza virus and other respiratory viruses' infection during three seasons in Tunisia. keywords: a(h1n1)pdm09; cases; influenza; pandemic; season; surveillance; tunisia; viruses cache: cord-302529-43pd2qsp.txt plain text: cord-302529-43pd2qsp.txt item: #433 of 672 id: cord-302962-qw6s1t7j author: Hause, Ben M. title: Bovine Rhinitis Viruses Are Common in U.S. Cattle with Bovine Respiratory Disease date: 2015-03-19 words: 4951 flesch: 52 summary: In addition to controlled studies, numerous investigations of acute respiratory disease in cattle resulted in the isolation of bovine rhinitis viruses where paired acute and convalescent sera suggested a causative role for bovine rhinitis virus The PCR assay specificity was confirmed using bovine rhinitis virus positive samples as determined by metagenomic sequencing as well as with cultures of common BRDC pathogens BVDV, BHV-1, BRSV, BCV, Mannheimia haemolytica, Histophilus somni, Pasteurella multocida and Mycoplasma bovis. keywords: bovine; brav2; brbv; brv; disease; reads; rhinitis; samples; virus; viruses cache: cord-302962-qw6s1t7j.txt plain text: cord-302962-qw6s1t7j.txt item: #434 of 672 id: cord-303034-w72oeoxq author: Haischer, Michael H. title: Who is wearing a mask? Gender-, age-, and location-related differences during the COVID-19 pandemic date: 2020-10-15 words: 4432 flesch: 50 summary: The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2 Reducing transmission of SARS-CoV-2 A modelling framework to assess the likely effectiveness of facemasks in combination with 'lock-down' in managing the COVID-19 pandemic United States Coronavirus Info; c2020 Temporal dynamics in viral shedding and transmissibility of COVID-19 Enviromental Health Matters Initiative Face coverings for the public: Laying straw men to rest Face masks for the public during the COVID-19 crisis Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: Additionally, mask mandates are necessary to increase mask wearing among the public to a level required to mitigate the spread of COVID-19. keywords: age; covid-19; data; individuals; mandates; mask; public; rural; wearing cache: cord-303034-w72oeoxq.txt plain text: cord-303034-w72oeoxq.txt item: #435 of 672 id: cord-303187-ny4qr2a2 author: Belo, Vinícius Silva title: Abundance, survival, recruitment and effectiveness of sterilization of free-roaming dogs: A capture and recapture study in Brazil date: 2017-11-01 words: 7692 flesch: 39 summary: Editora Ministério da Saúde A general methodology for the analysis of capture-recapture experiments in open populations U-CARE: utilities for performing goodness of fit tests and manipulating capture-recapture data Estimability and likelihood inference for generalized linear mixed models using data cloning Model Selection and Multi-Model Inference: A Practical Information-Theoretic Approach Information-theoretic model selection and model averaging for closed-population capture-recapture studies Studies on dog population and its implication for rabies control Assessing demographic and epidemiologic parameters of rural dog populations in India during mass vaccination campaigns A survey of the dog population in rural Bangladesh Free-roaming dog population estimation and status of the dog population management and rabies control program in Dhaka City Demography of domestic dogs in rural and urban areas of the Coquimbo region of Chile and implications for disease transmission Spacing and social organization: Urban stray dogs revisited Is survivorship a better fitness surrogate than fecundity? Fecundity and longevity of roaming dogs in Jaipur Population ecology of free-ranging urban dogs in West Bengal Age, sex, density, winter weather, and population crashes in Soay sheep Sex-and age-dependent effects of population density on life history traits of red deer Cervus elaphus in a temperate forest The Evolution of Parental Care Effects of maternal care on the lifetime reproductive success of females in a neotropical harvestman A seroepidemiologic survey of canine visceral leishmaniosis among apparently healthy dogs in Croatia Persistent Instability and Population Regulation in Soay Sheep Temporal changes in key factors and key age groups influencing the population dynamics of female red deer Assessing the impact of climate variation on survival in vertebrate populations Complex interplay between intrinsic and extrinsic drivers of long-term survival trends in southern elephant seals Loss of density-dependence and incomplete control by dominant breeders in a territorial species with density outbreaks Stochasticity and Determinism: How Density-Independent and Density-Dependent Processes Affect Population Variability Bayesian Inference on the Effect of Density Dependence and Weather on a Guanaco Population from Chile Density-Dependent Spacing Behaviour and Activity Budget in Pregnant, Domestic Goats (Capra hircus) Such information on the dynamics of free-ranging dogs are useful for informing control interventions of unrestricted dog populations and against canine visceral leishmaniasis and rabies, both neglected tropical diseases endemic to various countries. keywords: animals; areas; capture; control; dogs; dynamics; estimates; model; parameters; population; probability; recruitment; sterilization; study; survival cache: cord-303187-ny4qr2a2.txt plain text: cord-303187-ny4qr2a2.txt item: #436 of 672 id: cord-303331-xolksoy3 author: Pourghasemi, Hamid Reza title: Assessment of the outbreak risk, mapping and infection behavior of COVID-19: Application of the autoregressive integrated-moving average (ARIMA) and polynomial models date: 2020-07-28 words: 5991 flesch: 52 summary: This study also can aid local authorities in imposing strict social distancing measures in the regions with high outbreak risk. Sixteen effective factors were selected for spatial modelling of outbreak risk. keywords: cases; covid-19; distance; fars; infection; iran; mapping; model; outbreak; outbreak risk; province; risk cache: cord-303331-xolksoy3.txt plain text: cord-303331-xolksoy3.txt item: #437 of 672 id: cord-303490-rixuuytu author: Pazos, Michael A. title: Estrogen Mediates Innate and Adaptive Immune Alterations to Influenza Infection in Pregnant Mice date: 2012-07-05 words: 6650 flesch: 40 summary: Vaccine Birth outcomes among women exposed to neuraminidase inhibitors during pregnancy Influenza virus infections in pregnant mice Influenza infections during pregnancy in the mouse Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden, in pregnant mice Estriol ameliorates autoimmune demyelinating disease: implications for multiple sclerosis Enhancement of collagen-induced arthritis in female mice by estrogen receptor blockage Maintained pregnancy levels of oestrogen afford complete protection from post-partum exacerbation of collagen-induced arthritis Treatment of multiple sclerosis with the pregnancy hormone estriol Cutting edge: stealth influenza virus replication precedes the initiation of adaptive immunity Effect of respiratory hospitalization during pregnancy on infant outcomes The complex role of estrogens in inflammation Sex hormones and the immune response in humans Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol Estrogen inhibits dendritic cell maturation to RNA viruses Antiviral instruction of bone marrow leukocytes during respiratory viral infections Type I IFNs enhance the terminal differentiation of dendritic cells Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection Influenza virus evades innate and adaptive immunity via the NS1 protein T cell responses during influenza infection: getting and keeping control The impact of sex, gender and pregnancy on 2009 H1N1 disease Elevated 17b-Estradiol Protects Females from Influenza A Virus Pathogenesis by Suppressing Inflammatory Responses Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor a but not estrogen receptor b Suppression of experimental autoimmune encephalomyelitis using estrogen receptor-selective ligands A question of selfpreservation: immunopathology in influenza virus infection The pathology of influenza virus infections Animal models of preterm birth Cachectin/ tumor necrosis factor-alpha formation in human decidua. Pregnancy has been an acknowledged risk factor for severe complications from influenza virus infection for nearly a century [15] , and has been observed during every major influenza pandemic including the pandemics of 1918 keywords: cd8; cells; cytokine; estrogen; figure; infection; influenza; levels; lung; mice; pregnancy; treatment; virus cache: cord-303490-rixuuytu.txt plain text: cord-303490-rixuuytu.txt item: #438 of 672 id: cord-303845-y6ws3u6x author: DeLisle, Sylvain title: Combining Free Text and Structured Electronic Medical Record Entries to Detect Acute Respiratory Infections date: 2010-10-14 words: 5616 flesch: 36 summary: A manual review of EMR entries constituted the reference standard for ARI case detection. Structured EMR parameters and free-text analyses can be combined into algorithms that can detect ARI cases with new levels of sensitivity or precision. keywords: ari; cases; cda; codes; data; detection; emr; icd-9; influenza; parameters; patients; study; surveillance; text cache: cord-303845-y6ws3u6x.txt plain text: cord-303845-y6ws3u6x.txt item: #439 of 672 id: cord-304616-k92fa15l author: Izes, Aaron M. title: Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected cats date: 2020-08-05 words: 4213 flesch: 44 summary: A simple, high pressure liquid chromatography assay was developed to detect mefloquine plasma concentrations in feline plasma. In vitro hepatic metabolism of mefloquine using microsomes from cats, dogs and the common brush-tailed possum (Trichosurus vulpecula) Predicting plasma protein binding of drugs: a new approach Drug-protein binding: a critical review of analytical tools Clinical pharmacokinetics of mefloquine Positive predictive value of albumin: globulin ratio for feline infectious peritonitis in a mid-western referral hospital population A high performance liquid chromatographic assay of mefloquine in saliva after a single oral dose in healthy adult Africans Defining limit of detection and limit of quantitation as applied to drug of abuse testing: striving for a consensus International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use Prevalence of feline immunodeficiency virus infection in domesticated and feral cats in eastern Australia Risk factors for feline infectious peritonitis in Australian cats pH adjustment of human blood plasma prior to bioanalytical sample preparation Chemistry (cobas) reference intervals In vitro hepatic metabolism of mefloquine using microsomes from cats, dogs and the common brush-tailed possum Clinical application of mefloquine pharmacokinetics in the treatment of P. falciparum malaria In vitro binding of cefovecin to plasma proteins in Australian marsupials and plasma concentrations of cefovecin following single subcutaneous administration to koalas (Phascolarctos cinereus) Species differences in drug plasma protein binding Selective plasma protein binding of antimalarial drugs to α1-acid glycoprotein Plasma protein binding and blood-free concentrations: which studies are needed to develop a drug? Serum protein concentrations in Plasmodium falciparum malaria Critical assessment of the diagnostic value of feline α1-acid glycoprotein for feline infectious peritonitis using the likelihood ratios approach Protein binding of antimicrobials: methods for quantification and for investigation of its impact on bacterial killing Errors in estimating the unbound fraction of drugs due to the volume shift in equilibrium dialysis Clinical pharmacology: plasma protein binding of drugs What is the true clinical significance of plasma protein binding displacement interactions? keywords: binding; cats; concentrations; feline; fip; mefloquine; plasma; protein; samples cache: cord-304616-k92fa15l.txt plain text: cord-304616-k92fa15l.txt item: #440 of 672 id: cord-304993-t4rua95e author: Jung, Kwonil title: The Effects of Simvastatin or Interferon-α on Infectivity of Human Norovirus Using a Gnotobiotic Pig Model for the Study of Antivirals date: 2012-07-23 words: 7085 flesch: 42 summary: Different HBGA phenotypes (A or H) were shown to influence susceptibility of Gn pigs to HuNoV infection In our study, although HuNoV infection of Gn pigs induced mild enteric disease, Gn pigs were susceptible to oral infection by the GII.4 HS194 strain, which reaffirms the results of our previous studies using a closely related GII.4 HuNoV (HS66 strain) keywords: cells; cholesterol; expression; hunov; infection; levels; nhifn; pigs; poly; shedding; simvastatin; treatment; virus cache: cord-304993-t4rua95e.txt plain text: cord-304993-t4rua95e.txt item: #441 of 672 id: cord-305071-4ck8nd24 author: Calvo, Cristina title: Eight Year Prospective Study of Adenoviruses Infections in Hospitalized Children. Comparison with Other Respiratory Viruses date: 2015-07-06 words: 3527 flesch: 45 summary: Finally, we have performed a comparison between HAdV single infections, and the most important circulating virus in the same populations and period. Frequency and clinical course of HAdV infections were compared with RSV, rhinovirus (RV), human bocavirus (HBoV) and influenza in the same population. keywords: adenovirus; cases; children; fever; hadv; infections; patients cache: cord-305071-4ck8nd24.txt plain text: cord-305071-4ck8nd24.txt item: #442 of 672 id: cord-305274-mcsdem7y author: Beniac, Daniel R. title: Conformational Reorganization of the SARS Coronavirus Spike Following Receptor Binding: Implications for Membrane Fusion date: 2007-10-24 words: 5481 flesch: 46 summary: Found at: doi:10.1371/journal.pone.0001082.s001 (7.24 MB MOV) Movie S2 Three-dimensional morphing of the SARS spike, and ACE2 bound structures. Viral membrane fusion proteins are responsible both for binding to cellular receptors, and the subsequent fusion of viral and cellular membranes. keywords: ace2; binding; cell; cov; cryo; fusion; membrane; receptor; sars; sars spike; spike; structure; virus cache: cord-305274-mcsdem7y.txt plain text: cord-305274-mcsdem7y.txt item: #443 of 672 id: cord-305303-82n96ukr author: Shapira, Assaf title: Removal of Hepatitis C Virus-Infected Cells by a Zymogenized Bacterial Toxin date: 2012-02-16 words: 10191 flesch: 37 summary: These zymoxins showed a higher level of cytotoxicity when applied to NS3 expressing cells or to HCV infected cells, demonstrating a potential therapeutic window. To evaluate the potential of the NS3-cleavable MazF based zymoxin in eradication of NS3 expressing cells, three 96 well plates were seeded with Tet-inducible full NS3-4A, Tet-NS3/activated MazF or Tet-NS3/uncleavable MazF cells and were supplemented with 3 fold serial dilutions of tetracycline starting with 1000 ng/ ml. keywords: cells; encoding; hcv; infected; mazf; mazf cells; mcherry; ns3; peptide; protease; protein; tet; toxin; uncleavable; uncleavable mazf; virus; zymoxin cache: cord-305303-82n96ukr.txt plain text: cord-305303-82n96ukr.txt item: #444 of 672 id: cord-305393-96mrxt8a author: Lai, Yvonne title: Viral Double-Strand RNA-Binding Proteins Can Enhance Innate Immune Signaling by Toll-Like Receptor 3 date: 2011-10-10 words: 9628 flesch: 53 summary: The transfected cells were induced 18 to 22 h later by the addition of poly(I:C) or viral dsRNAs to the culture medium to a final concentration of 1 mg/ mL in the presence or absence of 100 nM of RNA binding proteins. (TIF) Plant and animal sensors of conserved microbial signatures Innate immune recognition of viral infection Intracellular pattern recognition receptors in the host response Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing Sensing and signaling in antiviral innate immunity Structure and function of Toll receptors and their ligands A missense mutation of the Toll-like receptor 3 gene in a patient with influenzaassociated encephalopathy TLR3 deficiency in patients with herpes simplex encephalitis Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity Dissecting TLR3 signalling in dendritic cells The Toll-like receptor 3:dsRNA signaling complex Leucinerich repeats and pathogen recognition in Toll-like receptors Predicting Toll-like receptor structures and characterizing ligand binding The TLR3 signaling complex forms by cooperative receptor dimerization Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain mRNA is an endogenous ligand for Toll-like receptor 3 LL37 and cationic peptides enhance TLR3 signaling by viral doublestranded RNAs Replication of hepatitis C virus HCV NS5B polymerase inhibitors Template requirements for RNA synthesis by a recombinant hepatitis C virus RNAdependent RNA polymerase De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus Mechanism of de novo initiation by the hepatitis C virus RNA-dependent RNA polymerase: role of divalent metals Requirements for de novo initiation of RNA synthesis by recombinant flaviviral RNA-dependent RNA polymerases De novo initiation pocket mutations have multiple effects on hepatitis C virus RNAdependent RNA polymerase activities A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase Regulation of de novo-initiated RNA synthesis in hepatitis C virus RNA-dependent RNA polymerase by intermolecular interactions De novo initiation of viral RNA-dependent RNA synthesis Structural and functional analysis of hepatitis C virus strain JFH1 polymerase A comprehensive structure-function comparison of hepatitis C virus strain JFH1 and J6 polymerases reveals a key residue stimulating replication in cell culture across genotypes Ross River virus transmission, infection, and disease: a cross-disciplinary review The coat protein leads the way: an update on basic and applied studies with the Brome mosaic virus coat protein Hepatitis B virus infection-natural history and clinical consequences Virus assembly, allostery and antivirals Effects of deletions in the N-terminal basic arm of brome mosaic virus coat protein on RNA packaging and systemic infection Biological significance of the seven aminoterminal basic residues of brome mosaic virus coat protein Fulllength hepatitis B virus core protein packages viral and heterologous RNA with similarly high levels of cooperativity In vitro-assembled alphavirus core-like particles maintain a structure similar to that of nucleocapsid cores in mature virus Cutting Edge: keywords: 1bd21; beas-2b; binding; cells; dsrna; fig; hcv; il6; poly(i; polymerase; production; proteins; rna; signaling; tlr3; virus cache: cord-305393-96mrxt8a.txt plain text: cord-305393-96mrxt8a.txt item: #445 of 672 id: cord-305547-e66o5j85 author: Bénet, Thomas title: Etiology and Factors Associated with Pneumonia in Children under 5 Years of Age in Mali: A Prospective Case-Control Study date: 2015-12-22 words: 4165 flesch: 40 summary: Among pneumonia cases, 30.5% were hypoxemic at admission, mortality was 4.2%. Pneumonia cases differed from the controls regarding clinical signs and symptoms but not in terms of past medical history. keywords: cases; children; controls; etiology; mali; patients; pneumonia cache: cord-305547-e66o5j85.txt plain text: cord-305547-e66o5j85.txt item: #446 of 672 id: cord-305811-987dhnf7 author: Cho, Che-Pei title: Regulation of Programmed Ribosomal Frameshifting by Co-Translational Refolding RNA Hairpins date: 2013-04-29 words: 5863 flesch: 45 summary: Because widely distributed RNA structures along an open reading-frame [28] are unwound and refolded repeatedly during translation, the involvement of refolding RNA hairpins in the regulation of translational elongation may be more common than first thought. As E site sequences can affect the potency of downstream stimulators [12, 13] , we ask whether the potency of attenuators can be affected by either proximal E site sequences or downstream stimulators. keywords: activity; attenuation; base; fig; frameshifting; hairpin; pairs; prf; ribosomal; ribosome; rna; site; stem cache: cord-305811-987dhnf7.txt plain text: cord-305811-987dhnf7.txt item: #447 of 672 id: cord-305900-ht7hb2rc author: van den Brand, Judith M. A. title: Comparison of Temporal and Spatial Dynamics of Seasonal H3N2, Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Virus Infections in Ferrets date: 2012-08-08 words: 9469 flesch: 44 summary: (DOC) Pathology of human influenza revisited Comparison of the pathology caused by H1N1, H5N1, and H3N2 influenza viruses The pathology of influenza virus infections Number of human H5N1 cases Comparative pathology of select agent influenza a virus infections Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals The ferret: an animal model to study influenza virus Efficacy of vaccination with different combinations of MF59-adjuvanted and non-adjuvanted seasonal and pandemic influenza vaccines against pandemic H1N1 (2009) influenza in ferrets Local innate immune responses and influenza virus transmission and virulence in ferrets Pathogenesis of avian influenza A (H5N1) viruses in ferrets Pathogenesis and transmission of triple-reassortant swine H1N1 influenza viruses isolated before the 2009 H1N1 pandemic Modeling host responses in ferrets during A/California/07/2009 influenza infection Course of seasonal influenza A/Brisbane/59/07 H1N1 infection in the ferret Comparative pathology in ferrets infected with H1N1 influenza A viruses isolated from different hosts Virulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferrets Interactions of surfactant protein A with influenza A viruses: binding and neutralization Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques Severity of pneumonia due to new H1N1 influenza virus in ferrets is intermediate between that due to seasonal H1N1 virus and highly pathogenic avian influenza H5N1 virus Alveolar edema fluid clearance and acute lung injury Upregulation of alveolar epithelial fluid transport after subacute lung injury in rats from bleomycin Estrogen regulation of nitric oxide and inducible nitric oxide synthase (iNOS) in immune cells: implications for immunity, autoimmune diseases, and apoptosis Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia Avian influenza A (H5N1) infection in eastern Turkey in 2006 Update on avian influenza A (H5N1) virus infection in humans Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals Inefficient transmission of H5N1 influenza viruses in a ferret contact model Pathogenesis of Influenza A/H5N1 virus infection in ferrets differs between intranasal and intratracheal routes of inoculation Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004 Depletion of lymphocytes and diminished cytokine production in mice infected with a highly virulent influenza A (H5N1) virus isolated from humans Influenza This is because influenza virus infection is a highly dynamic process, both temporally and spatially. keywords: alveolar; antigen; cells; dpi; expression; ferrets; figure; h5n1; infection; influenza; table; tract; virus cache: cord-305900-ht7hb2rc.txt plain text: cord-305900-ht7hb2rc.txt item: #448 of 672 id: cord-306135-pt4jsr6d author: Chan, Kamfai title: A Rapid and Low-Cost PCR Thermal Cycler for Infectious Disease Diagnostics date: 2016-02-12 words: 6327 flesch: 52 summary: While others have reported fast PCR reactions using various approaches, seldom were the systems challenged with PCR reactions containing low numbers of template per PCR reaction. Speeding up PCR reactions when polypropylene tubes are used While polypropylene plastic tubes are commonly used in most commercial thermal cycles, they are not ideal for achieving a fast PCR reaction time because of the slow heat transfer between the plastic and the heating element. keywords: cycles; min; pcr; reaction; rna; temperature; thermal; time; ttc; tubes; ° c cache: cord-306135-pt4jsr6d.txt plain text: cord-306135-pt4jsr6d.txt item: #449 of 672 id: cord-306278-c4q4la5c author: Esposito, Susanna title: Epidemiology and Clinical Characteristics of Respiratory Infections Due to Adenovirus in Children Living in Milan, Italy, during 2013 and 2014 date: 2016-04-05 words: 4662 flesch: 43 summary: Overall, little data on HAdV circulation have been collected in Europe and no recent data regarding the epidemiology, molecular characterization, and clinical features of respiratory HAdV infections in children have been collected in Italy. [22, 23] , where this virus was the predominant type for respiratory HAdV infection from 1981 to 2002. keywords: adenovirus; cases; children; hadv; infection; load; pcr; species; study; time cache: cord-306278-c4q4la5c.txt plain text: cord-306278-c4q4la5c.txt item: #450 of 672 id: cord-306466-y4yg42p8 author: Nofal, Ahmed Maged title: Who complies with COVID-19 transmission mitigation behavioral guidelines? date: 2020-10-08 words: 5729 flesch: 33 summary: Importantly, when adding controls in Model 2, we now find that extraversion negatively influences the tendency of people to comply with COVID-19 transmission mitigation behavioral guidelines, meanwhile agreeableness, conscientiousness, and openness to experience positively influence the tendency of people to Big five personality traits and COVID-19 behavioral guidelines While we are cautious about causality issues given the cross-sectional nature of our data, we emphasize that COVID-19 transmission mitigation behavioral guidelines are a result of an exogenous shock (i.e. the sudden outbreak of COVID-19). key: cord-306466-y4yg42p8 authors: Nofal, Ahmed Maged; Cacciotti, Gabriella; Lee, Nick title: Who complies with COVID-19 transmission mitigation behavioral guidelines? date: 2020-10-08 journal: PLoS One DOI: 10.1371/journal.pone.0240396 sha: doc_id: 306466 cord_uid: y4yg42p8 During the past 6 months, the world has lost almost 950,000 lives because of the outbreak of COVID-19, with more than 31 million individuals diagnosed with COVID-19 worldwide. keywords: covid-19; covid-19 transmission; guidelines; individuals; mitigation; people; personality; transmission; transmission mitigation cache: cord-306466-y4yg42p8.txt plain text: cord-306466-y4yg42p8.txt item: #451 of 672 id: cord-306958-8bx8kxxh author: Christensen, Sarah R. title: Political and personal reactions to COVID-19 during initial weeks of social distancing in the United States date: 2020-09-24 words: 4276 flesch: 41 summary: This survey examined attitudes toward media, government, and community responses to COVID-19 by political ideology and sociodemographic factors. Questions assessed political ideology, scientific trust, and media consumption, as well as attitudes, anxieties, impacts, and knowledge related to COVID-19. keywords: covid-19; government; health; ideology; media; pandemic; respondents; u.s cache: cord-306958-8bx8kxxh.txt plain text: cord-306958-8bx8kxxh.txt item: #452 of 672 id: cord-307036-n44yml79 author: Ng, Oi-Wing title: Substitution at Aspartic Acid 1128 in the SARS Coronavirus Spike Glycoprotein Mediates Escape from a S2 Domain-Targeting Neutralizing Monoclonal Antibody date: 2014-07-14 words: 8556 flesch: 52 summary: S protein containing the substitution of D1128 with alanine (D1128A) exhibited a significant decrease in binding capability to mAb 1A9 compared to wild-type S protein. Every surface spike of the SARS-CoV is composed of a trimer of S protein of 1255 amino acids in length. keywords: 1a9; cells; coronavirus; cov; d1128a; mab; mutant; n1056k; protein; sars; type; virus cache: cord-307036-n44yml79.txt plain text: cord-307036-n44yml79.txt item: #453 of 672 id: cord-307540-dr5m9pfk author: Coelho, Flávio C. title: Assessing the spread of COVID-19 in Brazil: Mobility, morbidity and social vulnerability date: 2020-09-18 words: 3520 flesch: 49 summary: To identify regions with high geographical and social vulnerability, we proposed a classification scheme based on three main criteria: population mobility, socio-demographic-economic characteristics, and the available health care infrastructure in terms of hospital capacity. Number of COVID-19 cases notified per day was obtained from the site brasil.io/dataset/ covid19/casofull. keywords: areas; covid-19; micro; mobility; number; paulo; population; regions cache: cord-307540-dr5m9pfk.txt plain text: cord-307540-dr5m9pfk.txt item: #454 of 672 id: cord-307934-84zfabti author: Lai, Chao-Kuen title: Nonstructural Protein 5A Is Incorporated into Hepatitis C Virus Low-Density Particle through Interaction with Core Protein and Microtubules during Intracellular Transport date: 2014-06-06 words: 8230 flesch: 52 summary: Processing pathways of the hepatitis C virus proteins Expression and identification of hepatitis C virus polyprotein cleavage products Efficient initiation of HCV RNA replication in cell culture Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons Association of hepatitis C virus replication complexes with microtubules and actin filaments is dependent on the interaction of NS3 and NS5A Cytoskeletal requirements for hepatitis C virus (HCV) RNA synthesis in the HCV replicon cell culture system Initiation of hepatitis C virus infection requires the dynamic microtubule network: role of the viral nucleocapsid protein Hepatitis C virus egress and release depend on endosomal trafficking of core protein Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule-and dynein-dependent manner Hepatitis C virus: assembly and release of virus particles Homotypic interaction and multimerization of hepatitis C virus core protein Interaction of hepatitis C virus core protein with viral sense RNA and suppression of its translation The lipid droplet is an important organelle for hepatitis C virus production Subcellular localization of hepatitis C virus structural proteins in a cell culture system that efficiently replicates the virus An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles Ultrastructural and biophysical characterization of hepatitis C virus particles produced in cell culture Complete replication of hepatitis C virus in cell culture Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro Identification of a residue in hepatitis C virus E2 glycoprotein that determines scavenger receptor BI and CD81 receptor dependency and sensitivity to neutralizing antibodies Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome Characterization of low-and very-low-density hepatitis C virus RNA-containing particles Hepatitis C virus: buoyant density of the factor VIII-derived isolate in sucrose Hepatitis C virus particle detected by immunoelectron microscopic study Identification of hepatitis C virus by immunoelectron microscopy Visualization of hepatitis C virions and putative defective interfering particles isolated from lowdensity lipoproteins Production of infectious hepatitis C virus in tissue culture from a cloned viral genome An in vitro model of hepatitis C virion production B lymphocytes secrete antigen-presenting vesicles Exosomes: endosomal-derived vesicles shipping extracellular messages Shortrange exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication The heat shock cognate protein 70 is associated with hepatitis C virus particles and modulates virus infectivity Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras Robust production of infectious hepatitis C virus (HCV) from stably HCV cDNA-transfected human hepatoma cells Annexin A2 is involved in the formation of hepatitis C virus replication complex on the lipid raft Fluorescent detection of lipid droplets and associated proteins Effect of cell growth on hepatitis C virus (HCV) replication and a mechanism of cell confluence-based inhibition of HCV RNA and protein expression Hepatitis C virus RNA replication occurs on a detergent-resistant membrane that cofractionates with caveolin-2 Molecular determinants and dynamics of hepatitis C virus secretion Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway The ESCRT system is required for hepatitis C virus production Vps4 and the ESCRT-III complex are required for the release of infectious hepatitis C virus particles Membrane fusion and fission: enveloped viruses Association of hepatitis C virus envelope proteins with exosomes Microvesicles and viral infection Hepatitis C virus core particle detected by immunoelectron microscopy and optical rotation technique Buoyant density of hepatitis C virus recovered from infected hosts: two different features in sucrose equilibrium density-gradient centrifugation related to degree of liver inflammation Extraordinarily low density of hepatitis C virus estimated by sucrose density gradient centrifugation and the polymerase chain reaction The Phe105 loop of Alix Bro1 domain plays a key role in HIV-1 release A pathogenic picornavirus acquires an envelope by hijacking cellular membranes HIV and mature dendritic cells: Trojan exosomes riding the Trojan horse? NS2 protein of influenza virus is found in purified virus and phosphorylated in infected cells The paramyxovirus SV5 V protein binds two atoms of zinc and is a structural component of virions Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3 Localization of the Vpx packaging signal within the C terminus of the human immunodeficiency virus type 2 Gag precursor protein Alpha-helical peptide-induced vesicle rupture revealing new insight into the vesicle fusion process as monitored in situ by quartz crystal microbalance-dissipation and reflectometry Mechanism of an amphipathic alpha-helical peptide's antiviral activity involves sizedependent virus particle lysis Hepatitis C virus entry depends on clathrin-mediated endocytosis We thank Dr. Takaji Wakita of National Institute of Infectious Disease, Tokyo, Japan, for plasmid pJFH1, Dr. Charles M. Rice from Center for the Study of Hepatitis C, Rockefeller University, New York, USA, for Huh7.5 cells. None of the fractions obtained from these cells contained HCV NS5A protein (data not shown), consistent with the previous report [34] . keywords: anti; cells; core; core protein; density; fig; hcv; hepatitis; membrane; ns5a; particles; protein; rna; virus cache: cord-307934-84zfabti.txt plain text: cord-307934-84zfabti.txt item: #455 of 672 id: cord-308249-es948mux author: Dokuka, Sofia title: How academic achievement spreads: The role of distinct social networks in academic performance diffusion date: 2020-07-27 words: 5048 flesch: 44 summary: In this paper, we analyze the diffusion of academic performance across different types of student social networks. In this paper, we consider the transmission of academic performance within student social networks. keywords: behavior; diffusion; effect; friendship; networks; performance; students; study; ties cache: cord-308249-es948mux.txt plain text: cord-308249-es948mux.txt item: #456 of 672 id: cord-308261-hxlebas8 author: Broekhuis, Femke title: Using GPS collars to investigate the frequency and behavioural outcomes of intraspecific interactions among carnivores: A case study of male cheetahs in the Maasai Mara, Kenya date: 2019-04-03 words: 4778 flesch: 45 summary: Reduced temporal partitioning among Africa's large carnivores Movement activity based classification of animal behaviour with an application to data from cheetah (Acinonyx jubatus) Spatial and behavioral changes by red foxes (Vulpes vulpes) in response to artificial territory intrusion Field observation of two males following a female in the Iberian lynx (Lynx pardinus) during the mating season Genetic analysis reveals promiscuity among female cheetahs The evolution of fatal fighting Relating long-term studies to conservation practice: The case of the Serengeti Cheetah Project Acinonyx jubatus) population: the first 25 years Male turnover reduces population growth: An enclosure experiment on voles Intraspecific interactions among carnivores: A case study of male cheetahs Possible negative effects of adult male mortality on female grizzly bear reproduction Do male cheetahs Acinonyx jubatus commit infanticide? key: cord-308261-hxlebas8 authors: Broekhuis, Femke; Madsen, Emily K.; Keiwua, Kosiom; Macdonald, David W. title: Using GPS collars to investigate the frequency and behavioural outcomes of intraspecific interactions among carnivores: A case study of male cheetahs in the Maasai Mara, Kenya date: 2019-04-03 journal: PLoS One DOI: 10.1371/journal.pone.0213910 sha: doc_id: 308261 cord_uid: hxlebas8 Intraspecific interactions between individuals or groups of individuals of the same species are an important component of population dynamics. keywords: cheetahs; data; dyad; encounter; individuals; interactions; male; marking; posts; proximity cache: cord-308261-hxlebas8.txt plain text: cord-308261-hxlebas8.txt item: #457 of 672 id: cord-308344-ao9z00t7 author: Diep, Nguyen Van title: Novel Porcine Epidemic Diarrhea Virus (PEDV) Variants with Large Deletions in the Spike (S) Gene Coexist with PEDV Strains Possessing an Intact S Gene in Domestic Pigs in Japan: A New Disease Situation date: 2017-01-17 words: 4211 flesch: 47 summary: (DOCX) Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines An apparently new syndrome of porcine epidemic diarrhoea A new coronavirus-like particle associated with diarrhea in swine Porcine epidemic diarrhea virus infection: Etiology, epidemiology, pathogenesis and immunoprophylaxis Heterogeneity in spike protein genes of porcine epidemic diarrhea viruses isolated in Korea Porcine epidemic diarrhea virus variants with high pathogenicity New variants of porcine epidemic diarrhea virus, China Emergence of Porcine epidemic diarrhea virus in the United States: clinical signs, lesions, and viral genomic sequences Distinct characteristics and complex evolution of PEDV strains Comparison of porcine epidemic diarrhea viruses from Germany and the United States Complete genome sequence of a porcine epidemic diarrhea s gene indel strain isolated in france in Complete genome sequence of a porcine epidemic diarrhea virus from a novel outbreak in belgium PubMed Central Outbreak-related porcine epidemic diarrhea virus strains similar to US strains, South Korea US-like strain of porcine epidemic diarrhea virus outbreaks in Taiwan US-like isolates of porcine epidemic diarrhea virus from Japanese outbreaks between New variant of porcine epidemic diarrhea virus, United States Cell culture isolation and sequence analysis of genetically diverse US porcine epidemic diarrhea virus strains including a novel strain with a large deletion in the spike gene Novel porcine epidemic diarrhea virus variant with large genomic deletion New porcine epidemic diarrhoea virus variant with a large deletion in the spike gene identified in domestic pigs Detection and molecular diversity of spike gene of porcine epidemic diarrhea virus in China Cloning and further sequence analysis of the spike gene of attenuated porcine epidemic diarrhea virus DR13 Porcine epidemic diarrhea virus: An emerging and re-emerging epizootic swine virus Genetic diversity of ORF3 and spike genes of porcine epidemic diarrhea virus in Thailand Molecular characterization and phylogenetic analysis of porcine epidemic diarrhea virus (PEDV) samples from field cases in Fujian Differentiation of a Vero cell adapted porcine epidemic diarrhea virus from Korean field strains by restriction fragment length polymorphism analysis of ORF 3 PEDV ORF3 encodes an ion channel protein and regulates virus production Molecular epidemiology of porcine epidemic diarrhea virus in China Isolation and serial propagation of porcine epidemic diarrhea virus in cell cultures and partial characterization of the isolate An immunohistochemical investigation of porcine epidemic diarrhoea Porcine epidemic diarrhea: its diagnosis and control Molecular characterization of pig epidemic diarrhoea viruses isolated in Japan from Differential detection of transmissible gastroenteritis virus and porcine epidemic diarrhea virus by duplex RT-PCR Sequence determination of the nucleocapsid protein gene of the porcine epidemic diarrhoea virus confirms that this virus is a coronavirus related to human coronavirus 229E and porcine transmissible gastroenteritis virus MEGA6: Molecular Evolutionary Genetics Analysis version 6.0 Coronavirus spike proteins in viral entry and pathogenesis Identification of the epitope region capable of inducing neutralizing antibodies against the porcine epidemic diarrhea virus Identification of two novel B cell epitopes on porcine epidemic diarrhea virus spike protein The GPRLQPY motif located at the carboxy-terminal of the spike protein induces antibodies that neutralize Porcine epidemic diarrhea virus Mutations in the spike gene of porcine epidemic diarrhea virus associated with growth adaptation in vitro and attenuation of virulence in vivo Genetic variation analysis of reemerging porcine epidemic diarrhea virus prevailing in central China from Defective viral particles and viral disease processes Defective interfering viruses and their potential as antiviral agents Evolution, antigenicity and pathogenicity of global porcine epidemic diarrhea virus strains Cellular entry of the porcine epidemic diarrhea virus Establishment of feline intestinal epithelial cell cultures for the propagation and study of feline enteric coronaviruses Manipulation of the porcine epidemic diarrhea virus genome using targeted RNA recombination Genetic evolution and tropism of transmissible gastroenteritis coronaviruses Diseases of Swine, Tenth Ed The work was conducted with funding from the University of Miyazaki (grant number 2014-70). keywords: diarrhea; epidemic; gene; pedv; porcine; strains; variants; virus cache: cord-308344-ao9z00t7.txt plain text: cord-308344-ao9z00t7.txt item: #458 of 672 id: cord-308480-t2vukbwp author: Liang, Zhongjie title: Molecular Basis of NDM-1, a New Antibiotic Resistance Determinant date: 2011-08-24 words: 4283 flesch: 43 summary: To explore the detailed mechanism for the susceptibility of the two antibiotics against NDM-1 positive strain, 100 mM meropenem was used as NDM-1 substrate, then 50 mM and 150 mM tigecycline or aztreonam were mixed with the reaction system as the inhibitors. Our study will provide clues to investigate the molecular basis of extended antibiotics resistance of NDM-1 and then accelerate the search for new antibiotics against NDM-1 positive strain in clinical studies. keywords: antibiotics; figure; hydrolysis; lactam; loop1; meropenem; protein; site; strain; structure cache: cord-308480-t2vukbwp.txt plain text: cord-308480-t2vukbwp.txt item: #459 of 672 id: cord-308764-9z4qcoqz author: Wei, Lin title: Transcriptome Analysis of Houttuynia cordata Thunb. by Illumina Paired-End RNA Sequencing and SSR Marker Discovery date: 2014-01-02 words: 5255 flesch: 47 summary: in China based on RAMP markers Anti-inflammatory effect of Houttuynia cordata injection Immunomodulatory and anti-SARS activities of Houttuynia cordata Temjenmongla Anticestodal activity of Houttuynia cordata leaf extract against Hymenolepis diminuta in experimentally infected rats Variation in chemical composition and antibacterial activities of essential oils from two species of Houttuynia cordata Thunb Biological and antibacterial activities of the natural herb Houttuynia cordata water extract against the intracellular bacterial pathogen salmonella within the RAW 264.7 macrophage Virucidal effects of the steam distillate from Houttuynia cordata and its components on HSV-1, influenza virus, and HIV Houttuynia cordata blocks HSV infection through inhibition of NF-kB activation vitro and in vivo effects of Houttuynia cordata on infectious bronchitis virus Pharmacodynamic experiment of the antivirus effect of Houttuynia cordata injection on influenza virus in mice Houttuyninum, an active constituent of Chinese herbal medicine, inhibits phosphorylation of HER2/neu receptor tyrosine kinase and the tumor growth of HER2/neuoverexpressing cancer cells Houttuynia cordata Thunb. using an oxidized frying oil-fed model Antioxidative effects of polyphenols in leaves of Houttuynia cordata on protein fragmentation by copper-hydrogen peroxide in vitro Inhibitory effects of Houttuynia cordata water extracts on anaphylactic reaction and mast cell activation Suppressive effects of Houttuynia cordata Thunb. keywords: analysis; cordata; h. cordata; houttuynia; markers; primer; reads; sequences; sequencing; ssr; ssrs; transcriptome; unigenes cache: cord-308764-9z4qcoqz.txt plain text: cord-308764-9z4qcoqz.txt item: #460 of 672 id: cord-309010-tmfm5u5h author: Dietert, Kristina title: Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia date: 2017-11-20 words: 7851 flesch: 26 summary: https://doi.org/10.1371/journal.pone.0188251.g010 Comparative histopathology of mouse models of acute pneumonia semiquantification of mouse pneumonia is inconceivable. Murine acute lung infection models mirror human pathologies in many aspects and contribute to our understanding of the disease and the development of novel treatment strategies. keywords: + +; acute; alveolar; cov; fig; iav; infection; lesions; lung; mers; mice; model; mouse; pathogen; pneumonia cache: cord-309010-tmfm5u5h.txt plain text: cord-309010-tmfm5u5h.txt item: #461 of 672 id: cord-309043-dlmx12vt author: von Brunn, Albrecht title: Analysis of Intraviral Protein-Protein Interactions of the SARS Coronavirus ORFeome date: 2007-05-23 words: 6742 flesch: 48 summary: We therefore cloned the SARS-CoV ORFeome by recombinatorial cloning (GATEWAY technology) and performed a genome-wide analysis for viral protein interactions by yeast-two-hybrid (Y2H) matrix screen. Known virus-host and intraviral interactions of SARS proteins were identified by a literature screen (see Tables S1 and S2). keywords: accessory; cells; coronavirus; cov; interactions; network; nsp2; nsp8; number; orf9b; proteins; replication; rna; sars; virus; y2h cache: cord-309043-dlmx12vt.txt plain text: cord-309043-dlmx12vt.txt item: #462 of 672 id: cord-309194-jtouafgd author: Lu, Xiao title: Lung ultrasound score in establishing the timing of intubation in COVID-19 interstitial pneumonia: A preliminary retrospective observational study date: 2020-09-03 words: 3673 flesch: 40 summary: Our study examined COVID-19 patients with interstitial pneumonia, using the clinical application of LUS to assess intubation timing. From February 14, 2020 to March 6, 2020, COVID-19 patients were admitted in the ICU of the Cancer Center of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. keywords: covid-19; intubation; lung; lus; patients; study; ultrasound cache: cord-309194-jtouafgd.txt plain text: cord-309194-jtouafgd.txt item: #463 of 672 id: cord-309471-lr68epyb author: Xia, Jingya title: Virus-Specific Immune Memory at Peripheral Sites of Herpes Simplex Virus Type 2 (HSV-2) Infection in Guinea Pigs date: 2014-12-08 words: 7026 flesch: 34 summary: The total number of ganglia/spinal cord-resident, HSV-specific CD4 + and CD8 + T cells was not different demonstrating the maintenance of both subsets of virus specific memory T cells at the sites of HSV-2 latency during the initial months after HSV-2 infection. We used genital HSV-2 infection of guinea pigs to assess the type and location of HSV-specific memory cells at peripheral sites of HSV-2 infection. keywords: cells; ganglia; genital; guinea; hsv; infection; memory; resident; specific; spinal; virus cache: cord-309471-lr68epyb.txt plain text: cord-309471-lr68epyb.txt item: #464 of 672 id: cord-309621-6jj19xpr author: Yu, Pin title: Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus date: 2017-02-24 words: 4647 flesch: 36 summary: Here, we comprehensively describe the histopathological features of the disease and the distribution of the MERS-CoV antigen and DDP4 in rhesus macaque and common marmoset models. key: cord-309621-6jj19xpr authors: Yu, Pin; Xu, Yanfeng; Deng, Wei; Bao, Linlin; Huang, Lan; Xu, Yuhuan; Yao, Yanfeng; Qin, Chuan title: Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus date: 2017-02-24 journal: PLoS One DOI: 10.1371/journal.pone.0172093 sha: doc_id: 309621 cord_uid: 6jj19xpr Middle East respiratory syndrome (MERS), which is caused by a newly discovered coronavirus (CoV), has recently emerged. keywords: alveolar; cells; cov; infection; lungs; macaques; marmosets; mers; pneumocytes; rhesus cache: cord-309621-6jj19xpr.txt plain text: cord-309621-6jj19xpr.txt item: #465 of 672 id: cord-309981-4p3ybrn1 author: Dai, Ling-Ling title: Anxiety and depressive symptoms among COVID-19 patients in Jianghan Fangcang Shelter Hospital in Wuhan, China date: 2020-08-28 words: 3561 flesch: 39 summary: Among them, 57 (18.6%) experienced anxiety symptoms, and 41 (13.4%) experienced depressive symptoms. Based on covariates with P < 0.10 as screening covariates, having a family member who has been confirmed with COVID-19, number of current physical symptoms, symptoms change after hospitalization, and poor sleep quality were the related factors of anxiety symptoms, and gender, education level, smoking history, drinking history, having a family member who has been confirmed COVID-19, number of current physical symptoms, symptoms change after hospitalization, and poor sleep quality were the related factors of depressive symptoms (see Table 1 ). keywords: anxiety; covid-19; fangcang; patients; quality; shelter; sleep; symptoms cache: cord-309981-4p3ybrn1.txt plain text: cord-309981-4p3ybrn1.txt item: #466 of 672 id: cord-310061-nro623aa author: Valitutto, Marc T. title: Detection of novel coronaviruses in bats in Myanmar date: 2020-04-09 words: 3682 flesch: 42 summary: Supporting information S1 Fauci AS The challenge of emerging and reemerging infectious diseases Factors in the emergence of infectious diseases Host range and emerging and reemerging pathogens Global trends in emerging infectious diseases Risk factors for human disease emergence Human ecology in pathogenic landscapes: two hypotheses on how land use change drives viral emergence Ecology of zoonoses; natural and unnatural histories Impacts of biodiversity on the emergence and transmission of infectious diseases Diseases of humans and their domestic mammals: pathogen characteristics, host range and the risk of emergence Bat origin of human coronaviruses Bats: Important reservoir hosts of emerging viruses Host and viral traits predict zoonotic spillover from mammals Bats as reservoirs of severe emerging infectious diseases Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor Bats are natural reservoirs of SARS-like coronaviruses Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats Middle East respiratory syndrome coronavirus in bats, Saudi Arabia Further evidence for bats as the evolutionary source of Middle East respiratory syndrome coronavirus A pneumonia outbreak associated with a new coronavirus of probable bat origin Global epidemiology of bat coronaviruses Bats and coronaviruses Discovery of seven novel mammalian and avian coronaviruses in the genus Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus Fatal swine acute diarrhea syndrome caused by an HKU2-related coronavirus of bat origin A new bat-HKU2-like coronavirus in swine Prevalence and genetic diversity of coronaviruses in bats from China Bat coronavirus in Brazil related to Appalachian Ridge and porcine epidemic diarrhea viruses Ecosystem services provided by bats Global patterns in coronavirus diversity Optimizing viral discovery in bats Global hotspots and correlates of emerging zoonotic diseases Emerging infectious diseases in southeast Asia: regional challenges to control Zoonoses in South-East Asia: a regional burden, a global threat Bat coronaviruses and experimental infection of bats, the Philippines Identification of a severe acute respiratory syndrome coronavirus-like virus in a leaf-nosed bat in Nigeria Identification of mosquito bloodmeals using mitochondrial cytochrome oxidase subunit I and cytochrome b gene sequences PREDICT 1 & 2 Test Data HealthMap Database Group C betacoronavirus in bat guano fertilizer Coronaviruses in guano from Pteropus medius bats in Peradeniya Diversity of coronavirus in bats from Eastern Thailand Virome profiling of bats from Myanmar by metagenomic analysis of tissue samples reveals more novel mammalian viruses Circulation of Alphacoronavirus, Betacoronavirus and Paramyxovirus in Hipposideros bat species in Zimbabwe Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission Bats, coronaviruses, and deforestation: Toward the emergence of novel infectious diseases? key: cord-310061-nro623aa authors: Valitutto, Marc T.; Aung, Ohnmar; Tun, Kyaw Yan Naing; Vodzak, Megan E.; Zimmerman, Dawn; Yu, Jennifer H.; Win, Ye Tun; Maw, Min Thein; Thein, Wai Zin; Win, Htay Htay; Dhanota, Jasjeet; Ontiveros, Victoria; Smith, Brett; Tremeau-Brevard, Alexandre; Goldstein, Tracey; Johnson, Christine K.; Murray, Suzan; Mazet, Jonna title: Detection of novel coronaviruses in bats in Myanmar date: 2020-04-09 journal: PLoS One DOI: 10.1371/journal.pone.0230802 sha: doc_id: 310061 cord_uid: nro623aa The recent emergence of bat-borne zoonotic viruses warrants vigilant surveillance in their natural hosts. keywords: bats; coronaviruses; guano; health; host; human; myanmar; samples; sars; species cache: cord-310061-nro623aa.txt plain text: cord-310061-nro623aa.txt item: #467 of 672 id: cord-310396-jitao9k0 author: Lei, Yu title: MAVS-Mediated Apoptosis and Its Inhibition by Viral Proteins date: 2009-03-07 words: 6050 flesch: 39 summary: Notably, host cell apoptosis is a successful strategy to impede viral replication and restrict virus spreading during a productive infection [6] . Host cell apoptosis has been reported to suppress viral replication and the subsequent production of infectious progeny viruses [19] . keywords: apoptosis; cell; cov; death; expression; fig; host; ifn; mavs; protein; responses; sars; virus cache: cord-310396-jitao9k0.txt plain text: cord-310396-jitao9k0.txt item: #468 of 672 id: cord-310438-744r7gc3 author: Chan, Ta-Chien title: The Impact of Matching Vaccine Strains and Post-SARS Public Health Efforts on Reducing Influenza-Associated Mortality among the Elderly date: 2010-06-25 words: 5086 flesch: 35 summary: [47] ; and (3) improvements in influenza vaccines through enhancement of innate immunity [48, 49, 50] . Data was collected on Taiwan's annual and monthly influenzaassociated mortality rates for the elderly population, monthly meteorological conditions (obtained from Taiwan's Central Weather Bureau), annual influenza vaccine strains (collected from the WHO) keywords: deaths; excess; influenza; mortality; p&i; post; sars; strains; taiwan; vaccine; viruses cache: cord-310438-744r7gc3.txt plain text: cord-310438-744r7gc3.txt item: #469 of 672 id: cord-310466-0lbbiq7u author: Fu, Yang-chih title: Representative Contact Diaries for Modeling the Spread of Infectious Diseases in Taiwan date: 2012-10-03 words: 4422 flesch: 46 summary: To ensure that such diary-based contact patterns provide accurate baseline data for policy implementation in densely populated Taiwan, we collected contact diaries from a national sample, using 3-stage systematic probability sampling and rigorous in-person interviews. To ensure that such diary-based contact patterns provide accurate baseline data for policy implementation, we collected contact diaries from a representative national sample in Taiwan and extracted realistic parameters for our simulation modeling of disease infections. keywords: age; contact; data; disease; respondents; social; survey; taiwan cache: cord-310466-0lbbiq7u.txt plain text: cord-310466-0lbbiq7u.txt item: #470 of 672 id: cord-310678-33c3mp1o author: Morgantini, Luca A. title: Factors contributing to healthcare professional burnout during the COVID-19 pandemic: A rapid turnaround global survey date: 2020-09-03 words: 3495 flesch: 44 summary: Barello et al. assessed 376 Italian HCPs who interacted with COVID-19 infected patients for their reported burnout, psychosomatic symptoms and self-perceived general health, finding in their study population high emotional burnout, physical symptoms, and work-related pressure [7] . Adequate PPE was protective against reported burnout (RR = 0�88, 95% CI = 0�79-0�97, P = 0�01). keywords: burnout; covid-19; hcps cache: cord-310678-33c3mp1o.txt plain text: cord-310678-33c3mp1o.txt item: #471 of 672 id: cord-310790-3ikgmiof author: Cherrak, Sabri Ahmed title: Potential bioactive glycosylated flavonoids as SARS-CoV-2 main protease inhibitors: A molecular docking and simulation studies date: 2020-10-15 words: 3496 flesch: 45 summary: In this work, a screening of natural flavonoids has been made and their potential inhibitory effect against SARS-CoV-2 Mpro by molecular docking and molecular dynamics has been tested. The results which are summarized in Table 1 show that natural aglycone flavonoids possess high docking scores; with a maximum score achieved by EGCG with -7,9 kcal.mol -1 . keywords: binding; cov-2; docking; fig; flavonoids; mpro; protease; protein; sars cache: cord-310790-3ikgmiof.txt plain text: cord-310790-3ikgmiof.txt item: #472 of 672 id: cord-310947-aqau2n7q author: Pan, Ji'An title: Genome-Wide Analysis of Protein-Protein Interactions and Involvement of Viral Proteins in SARS-CoV Replication date: 2008-10-01 words: 6850 flesch: 39 summary: In our screen, 1.4 protein interactions per viral protein on the average was detected, and this result is in the upper range of the detection rates of viral protein interactions obtained by yeast two-hybrid systems Nsp11 is a small polypeptide containing only 13 amino acids and no interaction was detected with it in various assays but nsp11 in the fusion with nsp10 (nsp10/ 11) could significantly enhance the binding capability of nsp10 with either nsp14 or nsp16, indicating that the small nsp11 may also play important roles in viral protein interactions and replication. keywords: activity; coronavirus; cov; genome; hybrid; interactions; nsp10; protein; replication; rna; sars; syndrome; system; transcription cache: cord-310947-aqau2n7q.txt plain text: cord-310947-aqau2n7q.txt item: #473 of 672 id: cord-311065-ie3gty6e author: Gaddi, Pamela J. title: IL-10 Mediated Regulation of Liver Inflammation during Acute Murine Cytomegalovirus Infection date: 2012-08-03 words: 6618 flesch: 41 summary: vivo IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection The role of IL-10 in mouse hepatitis virus-induced demyelinating encephalomyelitis IL-10 and natural regulatory T cells: two independent anti-inflammatory mechanisms in herpes simplex virusinduced ocular immunopathology Excess neutrophil infiltration during cytomegalovirus brain infection of interleukin-10-deficient mice Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virus IL-10 Regulates Viral Lung Immunopathology during Acute Respiratory Syncytial Virus Infection in Mice Immune responses and cytokine induction in the development of severe hepatitis during acute infections with murine cytomegalovirus Type I interferons regulate inflammatory cell trafficking and macrophage inflammatory protein 1alpha delivery to the liver Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1a (MIP-1a)-dependent pathways The roles of interferon-gamma and perforin in antiviral immunity in mice that differ in genetically determined NK-cell-mediated antiviral activity Perforin and granzymes have distinct roles in defensive immunity and immunopathology CXCR3-dependent recruitment of antigen-specific T lymphocytes to the liver during murine cytomegalovirus infection Comparing the kinetics of NK cells, CD4, and CD8 T cells in murine cytomegalovirus infection The dynamics of mouse cytomegalovirus-specific CD4 T cell responses during acute and latent infection The role of CD4 and CD8 T cells in viral infections Mechanisms for virus-induced liver disease: tumor necrosis factor-mediated pathology independent of natural killer and T cells during murine cytomegalovirus infection Increased weight loss with reduced viral replication in interleukin-10 knock-out mice infected with murine cytomegalovirus Murine cytomegalovirus infection down-regulates MHC class II expression on macrophages by induction of IL-10 Nonredundant roles for B cell-derived IL-10 in immune counter-regulation Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glands Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection Interleukin-10 repletion suppresses pro-inflammatory cytokines and decreases liver pathology without altering viral replication in murine cytomegalovirus (MCMV)-infected IL-10 knockout mice Expansion and contraction of the NK cell compartment in response to murine cytomegalovirus infection Specific and nonspecific NK cell activation during virus infection Expansion of protective CD8+ T-cell responses driven by recombinant cytomegaloviruses Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells A chemokine-to-cytokineto-chemokine cascade critical in antiviral defense IFN-alphabeta-mediated inflammatory responses and antiviral defense in liver is TLR9-independent but MyD88-dependent during murine cytomegalovirus infection Monocyte chemoattractant protein-1 and CCR2 interactions are required for IFN-alpha/ beta-induced inflammatory responses and antiviral defense in liver The murine cytomegalovirus immunomodulatory gene m152 prevents recognition of infected cells by M45-specific CTL but does not alter the immunodominance of the M45-specific CD8 T cell response in vivo Four distinct patterns of memory CD8 T cell responses to chronic murine cytomegalovirus infection Genome-wide analysis reveals a highly diverse CD8 T cell response to murine cytomegalovirus Cytomegalovirus hepatitis: characterization of the inflammatory infiltrate in resistant and susceptible mice Posttranscriptional regulation of II10 gene expression allows natural killer cells to express immunoregulatory function Systemic but not local infections elicit immunosuppressive IL-10 also alters the function of antigen-presenting cells such as dendritic cells and macrophages by limiting expression of MHC class II and costimulatory molecules, and the production of chemokines, thereby indirectly inhibiting T cell responses and controlling cellular accumulation keywords: cd8; cells; fig; il-10; infection; liver; mcmv; mice; responses cache: cord-311065-ie3gty6e.txt plain text: cord-311065-ie3gty6e.txt item: #474 of 672 id: cord-311074-j3fw4dfc author: Alviset, Sophie title: Continuous Positive Airway Pressure (CPAP) face-mask ventilation is an easy and cheap option to manage a massive influx of patients presenting acute respiratory failure during the SARS-CoV-2 outbreak: A retrospective cohort study date: 2020-10-14 words: 4848 flesch: 44 summary: Optimal respiratory support for COVID-19 patients presenting with acute hypoxemic respiratory failure, however, remains unknown. The role of face-mask CPAP in managing acute hypoxemic respiratory failure in COVID-19 patients warrants further investigation in larger prospective studies and comparison with other ways to manage hypoxemic respiratory failure, such as high flow nasal oxygen cannula keywords: covid-19; cpap; failure; hypoxemic; icu; intubation; patients; respiratory; study; ventilation cache: cord-311074-j3fw4dfc.txt plain text: cord-311074-j3fw4dfc.txt item: #475 of 672 id: cord-311288-6ttux2uu author: Luo, Chen title: What triggers online help-seeking retransmission during the COVID-19 period? Empirical evidence from Chinese social media date: 2020-11-03 words: 6205 flesch: 40 summary: Altruistic, egoistic, and reciprocity motivations for retweeting The dual-process approach to human sociality: A review Determinants of information retweeting in microblogging What you say is what you get: How self-disclosure in support seeking affects language use in support provision in online support forums Health organizations providing and seeking social support: A Twitterbased content analysis When Facebook is easier than face-to-face: Social support derived from Facebook in socially anxious individuals Sensitive self-disclosures, responses, and social support on Instagram: The case of #Depression Communication of social support in computer-mediated groups for people with disabilities An analysis of social support exchanges in online HIV/AIDS self-help groups You get what you give: The interplay between social support types and support provision is still under-investigated, particularly the comparison of different types' outcomes has not been thoroughly examined in the online context. keywords: covid-19; credibility; health; help; information; media; online; posts; proximity; retransmission; seeking; study; support cache: cord-311288-6ttux2uu.txt plain text: cord-311288-6ttux2uu.txt item: #476 of 672 id: cord-311531-wezrs7gc author: Parčina, Marijo title: Multicenter evaluation of the QIAstat Respiratory Panel—A new rapid highly multiplexed PCR based assay for diagnosis of acute respiratory tract infections date: 2020-03-12 words: 3586 flesch: 41 summary: The QIAstat Respiratory Panel(®) assay (QIAstat RP) is a multiplexed in vitro diagnostics test for the rapid simultaneous detection of 21 pathogens directly from respiratory samples, including human mastadenovirus A-G, primate bocaparvovirus 1+2, human coronavirus (HKU1, NL63, OC43, 229E), human metapneumovirus A/B, rhinovirus/enterovirus, influenza A virus (no subtype, subtype H1, H1N1/2009, H3), influenza B virus, human respirovirus 1+3, human orthorubulavirus 2+4, human orthopneumovirus, Bordetella pertussis, Chlamydia pneumoniae, Mycoplasma pneumoniae and Legionella pneumophila. For 440 of 445 specimens (98.9%), a valid result was obtained by the initial QIAstat RP testing. keywords: filmarray; influenza; pathogens; qiastat; qiastat rp; samples; testing cache: cord-311531-wezrs7gc.txt plain text: cord-311531-wezrs7gc.txt item: #477 of 672 id: cord-311941-0dpm35dd author: Jones, Bryony A. title: Calf-Level Factors Associated with Bovine Neonatal Pancytopenia – A Multi-Country Case-Control Study date: 2013-12-02 words: 5745 flesch: 52 summary: For case calves, the thrombocyte value was set at ,150610 9 /litre, the lower threshold of the reference range in the Netherlands. Case dams (dams of cases) had increased odds of being in second or more lactation rather than first lactation compared with control dams (dams of controls). keywords: bnp; calves; case; colostrum; control; dam; dams; odds; pregsure; vaccinated cache: cord-311941-0dpm35dd.txt plain text: cord-311941-0dpm35dd.txt item: #478 of 672 id: cord-312002-4qhvljpv author: Pacheco-Barrios, Kevin title: COVID-19 pandemic and Farr’s law: A global comparison and prediction of outbreak acceleration and deceleration rates date: 2020-09-17 words: 5436 flesch: 50 summary: Finally, we performed a post-hoc extraction of the new cases for June 10, 2020 (one point extraction), and the political actions against COVID-19 per country, from the University of Washington Health Index and Evaluation C: Both ratios are equal to 1; D: First ratio less than 1�0 but Second ratio higher than 1�0; E: both ratios are less than 1�0� � No cases for more than 10 days�� Data belong to June 09, on June 10 there was no cases reported�� The countries with end date beyond June 10 are countries having more than zero predicted cases or deaths after we ended our simulation (June 10, 2020), meaning they could continue with the pandemic wave beyond the end our simulation. The predominant region for both ratios was Europe, while high income countries were predominant for the R 1 and middle-income for R 2 ( Table 2 ). keywords: cases; countries; covid-19; data; deaths; epidemic; health; june; new cache: cord-312002-4qhvljpv.txt plain text: cord-312002-4qhvljpv.txt item: #479 of 672 id: cord-312033-iarl77n0 author: López Barreda, Rodrigo title: Poverty, quality of life and psychological wellbeing in adults with congenital heart disease in Chile date: 2020-10-08 words: 4065 flesch: 46 summary: A hypothesis Quality of life of patients with congenital heart diseases Living with CHD: quality of life (QOL) in early adult life Quality of life of adult congenital heart disease patients: a systematic review of the literature Medical factors that predict quality of life for young adults with congenital heart disease: What matters most? Patient-reported outcomes in adults with congenital heart disease: Inter-country variation, standard of living and healthcare system factors Personality traits, quality of life and perceived health in adolescents with congenital heart disease Depression and anxiety in adults with congenital heart disease: a pilot study Psychosocial functioning of the adult with congenital heart disease: a 20-33 years follow-up Hopelessness among adults with congenital heart disease: Cause for despair or hope? key: cord-312033-iarl77n0 authors: López Barreda, Rodrigo; Guerrero, Alonso; de la Cuadra, Juan Cristóbal; Scotoni, Manuela; Salas, Wilbaldo; Baraona, Fernando; Arancibia, Francisca; Uriarte, Polentzi title: Poverty, quality of life and psychological wellbeing in adults with congenital heart disease in Chile date: 2020-10-08 journal: PLoS One DOI: 10.1371/journal.pone.0240383 sha: doc_id: 312033 cord_uid: iarl77n0 The objective of this study was to assess the quality of life and psychological wellbeing of adults with congenital heart disease (CHD) in Chile, and to identify other associated factors. keywords: chd; disease; health; heart; life; patients; qol; quality; study cache: cord-312033-iarl77n0.txt plain text: cord-312033-iarl77n0.txt item: #480 of 672 id: cord-312367-24huwt3y author: Coelho, Camila title: Biochemical screening for SARS-CoV-2 main protease inhibitors date: 2020-10-06 words: 3381 flesch: 41 summary: Recent progresses in polymer and textile applications Benzophenone derivatives as cysteine protease inhibitors and biological activity against Leishmania(L.) amazonensis amastigotes Leishmanicidal therapy targeted to parasite proteases Molecular mechanisms of quinone cytotoxicity Sulfonic Acid Dyes: Inhibition of the Human Immunodeficiency Virus and Mechanism of Action Evans Blue Inhibits HBV Replication Through a Dual Antiviral Mechanism by Targeting Virus Binding and Capsid Assembly Evaluation and comparison of computational models Expression and purification of soluble His(6)-tagged TEV protease Use of a Fluorescence Plate Reader for Measuring Kinetic Parameters with Inner Filter Effect Correction Program DYNAFIT for the Analysis of Enzyme Kinetic Data: Application to HIV Proteinase The authors thank FastBio, Ribeirão Preto, Brazil for help with reagent importation. Thus, further work has to be carried out to corroborate whether hematoporphyrin is indeed a specific inhibitor of SARS-Cov-2 M pro and eventually a mediator of hematological disorders. keywords: compounds; cov-2; inhibitors; pro; protease; sars cache: cord-312367-24huwt3y.txt plain text: cord-312367-24huwt3y.txt item: #481 of 672 id: cord-312493-wbhji81g author: Tay, Ee Laine title: Exploring a Proposed WHO Method to Determine Thresholds for Seasonal Influenza Surveillance date: 2013-10-11 words: 4305 flesch: 45 summary: Flu Activity & Surveillance: Weekly US Influenza Surveillance Report Weekly Influenza Surveillance Overview In: Control Establishing thresholds for influenza surveillance in Victoria Can syndromic thresholds provide early warning of national influenza outbreaks? Methods for monitoring influenza surveillance data A routine tool for detection and assessment of epidemics of influenza-like syndromes in France A statistical algorithm for the early detection of outbreaks of infectious disease Epidemic features affecting the performance of outbreak detection algorithms Influenza surveillance in Europe: establishing epidemic thresholds by the Moving Epidemic Method Modelling influenza epidemic -can we detect the beginning and predict the intensity and duration? Detection of epidemics in their early stage through infectious disease surveillance Do CuSums have a role in routine communicable disease surveillance? Detecting the start of an influenza outbreak using exponentially weighted moving average charts Overview of Influenza Surveillance in the United States Laboratory-supported influenza surveillance in Victorian sentinel general practices Estimation of influenza vaccine effectiveness from routine surveillance data A medical locum service as a site for sentinel influenza surveillance Influenza-like illness surveillance using a deputising medical service corresponds to surveillance from sentinel general practices Laboratory diagnosis and surveillance of human respiratory viruses by PCR in H1N1 swine origin influenza infection in the United States and Europe in 2009 may be similar to H1N1 seasonal influenza infection in two Australian states in A comparison of data sources for the surveillance of seasonal and pandemic influenza in Victoria Influenza surveillance in Australia: we need to do more than count The use of thresholds to describe levels of influenza activity An Analysis of Variance Test for Normality (Complete Samples) Improving the Estimation of Influenza-Related Mortality Over a Seasonal Baseline Predicting the epidemic sizes of influenza A/H1N1, A/H3N2, and B: a statistical method The significance of increased influenza notifications during spring and summer of 2010-11 in Australia Pandemic influenza H1N1 2009 infection in Victoria, Australia: no evidence for harm or benefit following receipt of seasonal influenza vaccine in 2009 The aim of this study was to explore the feasibility of the WHO method for the calculation of influenza thresholds using a range of existing surveillance and laboratory data sources in one surveillance system. keywords: data; datasets; ili; influenza; laboratory; peak; season; surveillance; thresholds cache: cord-312493-wbhji81g.txt plain text: cord-312493-wbhji81g.txt item: #482 of 672 id: cord-312678-81gnmxbk author: Elayeh, Eman title: Before and after case reporting: A comparison of the knowledge, attitude and practices of the Jordanian population towards COVID-19 date: 2020-10-15 words: 5443 flesch: 48 summary: Similarly, participants practice towards preventing transmission of COVID-19 score was calculated by assigning a score of one for appropriate practices, while inappropriate practices were assigned a score of zero. Hence, we rapidly adapted our study in order to engage more participants and to evaluate how this reported case altered the KAP of Jordanian citizens. keywords: case; covid-19; disease; knowledge; participants; practices; reporting; study cache: cord-312678-81gnmxbk.txt plain text: cord-312678-81gnmxbk.txt item: #483 of 672 id: cord-312817-gskbu0oh author: Witte, Carmel title: Spatiotemporal network structure among “friends of friends” reveals contagious disease process date: 2020-08-06 words: 5927 flesch: 40 summary: Our friends-of-friends network analysis suggests that avian mycobacteriosis can spread through bird social networks. We took care in assembling our network to ensure that the edge construction between subjects and friends adhered to general recommendations for disease networks [26, 46, 47] . keywords: birds; disease; exposure; friends; incubation; infection; network; subject; time; transmission cache: cord-312817-gskbu0oh.txt plain text: cord-312817-gskbu0oh.txt item: #484 of 672 id: cord-313107-6cfenpxm author: Singh, Anirudh K. title: Evaluation of pooled sample analysis strategy in expediting case detection in areas with emerging outbreaks of COVID-19: A pilot study date: 2020-09-22 words: 2891 flesch: 45 summary: In a recent study Hogan and co-workers made a similar observation while assessing the utility of pooled sample testing strategy to detect community transmission of SARS-CoV-2 in San Francisco Bay Area, CA, USA. At the reported point prevalence of 4.8% among the individuals tested in this study, the NPV of pooled sample strategy was around 96%; thereby suggesting the possibility of missing infected cases and risking community transmission from undiagnosed individuals. keywords: covid-19; pcr; pools; samples; strategy; study; testing cache: cord-313107-6cfenpxm.txt plain text: cord-313107-6cfenpxm.txt item: #485 of 672 id: cord-313506-6bb4q7nv author: Sano, Akiko title: Physiological Level Production of Antigen-Specific Human Immunoglobulin in Cloned Transchromosomic Cattle date: 2013-10-24 words: 6718 flesch: 46 summary: In order to improve the functional interactions between the hIgM and bIgα/ Igβ proteins in the pre-BCR, as well as the overall functionality of hIgM in Tc bovine B cells, we constructed a gene-targeting vector to bovinize the CH2-TM2 domain of hIgM that is involved in interacting with bIgα/Igβ [18] . To detect surface hIgG on Tc bovine B cells, goat anti-hIgG (Life Technologies, Grand Island, NY) directly labeled with AF 488 was used. keywords: bovine; cattle; cell; clone; dt40; figure; fragment; gene; genomic; higg; hpabs; human; locus; pcr; site cache: cord-313506-6bb4q7nv.txt plain text: cord-313506-6bb4q7nv.txt item: #486 of 672 id: cord-314651-e4uaw5fy author: Zhao, Guangyu title: Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-Coronavirus date: 2015-12-23 words: 4174 flesch: 38 summary: Systemic inflammation is believed to be a primary reason for the severe outcome in MERS--CoV infections [14, 24] . To evaluate MERS-CoV infection in the hDPP4 transgenic mice, distribution of the viral antigen NP protein was assessed in mouse tissues by immunohistochemical staining. keywords: coronavirus; cov; day; east; fig; hdpp4; infection; mers; mice; syndrome; transgenic cache: cord-314651-e4uaw5fy.txt plain text: cord-314651-e4uaw5fy.txt item: #487 of 672 id: cord-314908-kp2jznwb author: Roczniewska, Marta title: I believe I can craft! introducing Job Crafting Self-Efficacy Scale (JCSES) date: 2020-08-10 words: 9303 flesch: 49 summary: JCSE explained unique variance in job crafting behaviors over and above general self-efficacy, and was more important in predicting job crafting than contextual factors. In the meta-analysis, general self-efficacy has been positively linked with job crafting behaviors [3] ; however, its predictive power was low to medium, and differed for distinct crafting behaviors. keywords: crafting; demands; efficacy; factor; jcse; job; model; resources; self; study cache: cord-314908-kp2jznwb.txt plain text: cord-314908-kp2jznwb.txt item: #488 of 672 id: cord-315343-ywgoqlxj author: Ribeiro, Haroldo V. title: City size and the spreading of COVID-19 in Brazil date: 2020-09-23 words: 5475 flesch: 52 summary: This result shows that large cities have a lower prevalence of adults older than 60 years, such that a 1% increase in city population is associated with a 0.91% rise in the high-risk population. However, during the long-term course of the pandemic, this urban advantage vanishes and large cities start to exhibit higher incidence of cases and deaths, such that every 1% rise in population is associated with a 0.14% increase in the number of fatalities per capita after about four months since the first two daily deaths. keywords: cases; cities; city; covid-19; deaths; number cache: cord-315343-ywgoqlxj.txt plain text: cord-315343-ywgoqlxj.txt item: #489 of 672 id: cord-315531-2gc2dc46 author: McGarvey, Peter B. title: Systems Integration of Biodefense Omics Data for Analysis of Pathogen-Host Interactions and Identification of Potential Targets date: 2009-09-25 words: 7018 flesch: 33 summary: Callable Personal Librarian (CPL) (version 65) UniRef: comprehensive and non-redundant UniProt reference clusters A data integration methodology for systems biology: experimental verification From bytes to bedside: data integration and computational biology for translational cancer research Integration of metabolomic and proteomic phenotypes: analysis of data covariance dissects starch and RFO metabolism from low and high temperature compensation response in Arabidopsis thaliana Comparative proteomics of human monkeypox and vaccinia intracellular mature and extracellular enveloped virions The utility of accurate mass and LC elution time information in the analysis of complex proteomes Cytoscape: a software environment for integrated models of biomolecular interaction networks Exploring biological networks with Cytoscape software Comparative assessment of large-scale data sets of protein-protein interactions A direct comparison of protein interaction confidence assignment schemes A relationship between gene expression and protein interactions on the proteome scale: analysis of the bacteriophage T7 and the yeast Saccharomyces cerevisiae Protein interactions: two methods for assessment of the reliability of high throughput observations Assessment of the reliability of protein-protein interactions and protein function prediction Gaining confidence in high-throughput protein interaction networks Vaccinia virus induces cell fusion at acid pH and this activity is mediated by the N-terminus of the 14-kDa virus envelope protein A 14K envelope protein of vaccinia virus with an important role in virus-host cell interactions is altered during virus persistence and determines the plaque size phenotype of the virus The oligomeric structure of vaccinia viral envelope protein A27L is essential for binding to heparin and heparan sulfates on cell surfaces: a structural and functional approach using site-specific mutagenesis Vaccinia virus envelope H3L protein binds to cell surface heparan sulfate and is important for intracellular mature virion morphogenesis and virus infection in vitro and in vivo Vaccinia virus envelope D8L protein binds to cell surface chondroitin sulfate and mediates the adsorption of intracellular mature virions to cells Vaccinia virus F9 virion membrane protein is required for entry but not virus assembly, in contrast to the related L1 protein The vaccinia virus gene I2L encodes a membrane protein with an essential role in virion entry Blockade of chemokine activity by a soluble chemokine binding protein from vaccinia virus Monkeypox virus viral chemokine inhibitor (MPV vCCI), a potent inhibitor of rhesus macrophage inflammatory protein-1 Identification of a peptide derived from vaccinia virus A52R protein that inhibits cytokine secretion in response to TLR-dependent signaling and reduces in vivo bacterial-induced inflammation A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense Molecular characterization and expression of the stratification-related cytokeratins 4 and 15 Mouse keratin 4 is necessary for internal epithelial integrity Clumping factor B, a fibrinogen-binding MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesin of Staphylococcus aureus, also binds to the tail region of type I cytokeratin 10 The surface protein Srr-1 of Streptococcus agalactiae binds human keratin 4 and promotes adherence to epithelial HEp-2 cells Vaccinia virus entry, exit, and interaction with differentiated human airway epithelia Protective effect of Toll-like receptor 4 in pulmonary vaccinia infection Computational identification of strain-, species-and genus-specific proteins A search method for homologs of small proteins. The MPD is built on the data and capabilities of iProClass [6] a warehouse of protein information, which in turn is built around UniProtKB keywords: analysis; anthracis; bacillus; data; gene; host; information; integration; interactions; mpd; pathogen; protein; proteomics; research; results; search; virus cache: cord-315531-2gc2dc46.txt plain text: cord-315531-2gc2dc46.txt item: #490 of 672 id: cord-316047-d9cpe9yl author: Gonzalez, T. title: Influence of COVID-19 confinement on students’ performance in higher education date: 2020-10-09 words: 8521 flesch: 57 summary: Most probably, different students will find different motivations in this new scenario (probably a combination of many). In this subject we have expressed student performance as a 0-10 score and analyzed it across all tests performed in self-evaluation. keywords: assessment; confinement; covid-19; learning; performance; stage; students; study; tests; years cache: cord-316047-d9cpe9yl.txt plain text: cord-316047-d9cpe9yl.txt item: #491 of 672 id: cord-316287-4i1grvlr author: Yim, Sung Sun title: Rapid Isolation of Antibody from a Synthetic Human Antibody Library by Repeated Fluorescence-Activated Cell Sorting (FACS) date: 2014-10-10 words: 6392 flesch: 46 summary: Strategies and challenges for the next generation of therapeutic antibodies High level production of a kringle domain variant by high-cell-density cultivation of Escherichia coli Advances in the production of human monoclonal antibodies Selecting and screening recombinant antibody libraries Synthetic therapeutic antibodies Yeast surface display for screening combinatorial polypeptide libraries Applications of display technology in protein analysis Targeting recombinant antibodies to the surface of E. coli: Fusion to a peptidoglycan associated lipoprotein Isolation of high-affinity ligand-binding proteins by periplasmic expression with cytometric screening (PECS) Separation of E. coli expressing functional cell-wall bound antibody fragments by FACS Anchored periplasmic expression, a versatile technology for the isolation of highaffinity antibodies from Escherichia coli-expressed libraries Development of an optimized expression system for the screening of antibody libraries displayed on the E. coli surface Nanogap field-effect transistor biosensors for electrical detection of avian influenza Label-free optical diagnosis of hepatitis B virus with genetically engineered fusion proteins High-yield production of the VP1 structural protein epitope from serotype O foot-andmouth disease virus in Escherichia coli Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity Universal Genetic Assay for Engineering Extracellular Protein Expression Kabat database and its applications: 30 years after the first variability plot Simultaneous mutagenesis of antibody CDR regions by overlap extension and PCR A vector for the removal of deletion mutants from antibody libraries Secretory production of recombinant protein by a high cell density culture of a protease negative mutant Escherichia coli strain Development of human anti-murine antibody (HAMA) response in patients The following strategy is usually used for screening a recombinant antibody library: (i) cultivation of library cells; (ii) fluorescent-antigenpeptide or protein labeling of the library cells; (iii) FACS sorting of the highly fluorescent population; (iv) regeneration of the sorted cells by regrowth or re-cloning of the sorted target genes; (v) repetition of steps i-iv until a highly fluorescent population is separated from the negative control population; and (vi) analysis of the individual clones. keywords: antibodies; antibody; antigen; cells; clones; coli; facs; fluorescent; library; scfv; screening; sorting cache: cord-316287-4i1grvlr.txt plain text: cord-316287-4i1grvlr.txt item: #492 of 672 id: cord-316319-m6uha1qn author: Daleno, Cristina title: Phylogenetic Analysis of Human Rhinovirus Isolates Collected from Otherwise Healthy Children with Community-Acquired Pneumonia during Five Successive Years date: 2013-11-19 words: 3976 flesch: 47 summary: HRV genotypes within each species detected among study subjects. Forty-seven (31.1%) of the children with HRV infection were aged <1 year, 71 (47.0%) were aged 1-3 years, and 33 (21.9%) were aged ≥4 years. keywords: children; genotypes; hrv; rhinovirus; species; strains; study cache: cord-316319-m6uha1qn.txt plain text: cord-316319-m6uha1qn.txt item: #493 of 672 id: cord-316703-8kxx3034 author: Parera, Mariona title: Canine Hepacivirus NS3 Serine Protease Can Cleave the Human Adaptor Proteins MAVS and TRIF date: 2012-08-01 words: 4200 flesch: 46 summary: Expression of NS3/4A proteases with a mutated version of NS4 partially abolished wildtype MAVS or TRIF repressor cleavage (Fig. 4) ; specifically, mutations in NS4 had less impact in the activity of CHV NS3/4A protease than in the activity of HCV NS3/4A protease (Fig. 4B) . We found that CHV NS3/4A protease could process, with comparable efficiency, the specific MAVS and TRIF cleavage sites known to be processed in vivo by HCV NS3/4A protease [14, 15] . keywords: chv; cleavage; fig; hcv; human; mavs; ns3/4a; protease; trif; virus cache: cord-316703-8kxx3034.txt plain text: cord-316703-8kxx3034.txt item: #494 of 672 id: cord-316853-vaea6siv author: Xie, Nanzhen title: Prevalence of depressive symptoms among nurses in China: A systematic review and meta-analysis date: 2020-07-07 words: 4364 flesch: 40 summary: Furthermore, the nationwide investigation of depressive symptoms prevalence should be performed with a standard diagnostic tool, which may be more useful for policy makers and planners. Furthermore, the nationwide investigation of depressive symptoms prevalence should be performed with a standard diagnostic tool, which may be more useful for policy makers and planners. keywords: analysis; chinese; depression; meta; nurses; prevalence; studies; study; symptoms cache: cord-316853-vaea6siv.txt plain text: cord-316853-vaea6siv.txt item: #495 of 672 id: cord-317058-anvmj4li author: Liu, Xinkui title: Analysis of clinical features and early warning signs in patients with severe COVID-19: A retrospective cohort study date: 2020-06-26 words: 3366 flesch: 48 summary: A higher number of patients showed signs of dyspnea in the severe group than in the non-severe group in our study, indicating that dyspnea was one of the main symptoms among patients with severe COVID-19; thus, a daily evaluation for dyspnea should be conducted among COVID-19 patients. In this study, we summarized the clinical features of COVID-19 patients and identified the early warning signs of severe COVID-19, which will help physicians determine which patients require further observation. keywords: covid-19; group; lymphocyte; patients; risk; study cache: cord-317058-anvmj4li.txt plain text: cord-317058-anvmj4li.txt item: #496 of 672 id: cord-317244-4su5on6s author: Maganga, Gael D. title: Identification of an Unclassified Paramyxovirus in Coleura afra: A Potential Case of Host Specificity date: 2014-12-31 words: 3483 flesch: 45 summary: A new mouse paramyxovirus (J virus) Isolation and molecular characterization of a novel cytopathogenic paramyxovirus from tree shrews Complete genome sequence of a novel paramyxovirus, Tailam virus, discovered in Sikkim rats Identification and phylogenetic comparison of Salem virus, a novel paramyxovirus of horses Reproduction and nutritional stress are risk factors for Hendra virus infection in little red flying foxes Bats host major mammalian paramyxoviruses Encephalitis caused by a lyssavirus in fruit bats in Australia Airborne transmission of lyssaviruses Rabies in nonhematophagous bats Guidelines of the American Society of Mammalogists for the use of wild mammals in research Ecological and behavioral methods for the study of bats Sensitive and broadly reactive reverse transcription-PCR assays to detect novel paramyxoviruses Marburg virus infection detected in a common African bat Newly discovered ebola virus associated with hemorrhagic Fever outbreak in Uganda Basic local alignment search tool MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance and Maximum Parsimony Methods MRBAYES: Bayesian inference of phylogenetic trees Isolation of Genetically Diverse Marburg Viruses from Egyptian Fruit Bats Studies of Reservoir Hosts for Marburg Virus Genomic characterizations of bat coronaviruses (1A, 1B and HKU8) and evidence for co-infections in Miniopterus bats Isolation of Hendra virus from pteropid bats: a natural reservoir of Hendra virus Bats are natural reservoirs of SARS-like coronaviruses Bats: important reservoir hosts of emerging viruses Novel astroviruses in insectivorous bats Bat white-nose syndrome: an emerging fungal pathogen? Inoculation of bats with European Geomyces destructans supports the novel pathogen hypothesis for the origin of white-nose syndrome Pathogenesis studies with Australian bat lyssavirus in grey-headed flying foxes (Pteropus poliocephalus) Bats and Lyssaviruses Discovery of an Ebolavirus-Like Filovirus in Europe Nipah virus infection in bats (Order Chiroptera) in Peninsular Malaysia Fruit bats as reservoirs of Ebola virus Is Marburg Virus Enzootic in Gabon? Bats as a continuing source of emerging infections in humans Risk factor for Nipah virus encephalitis in Bangladesh Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats Paramyxovirus and Pneumovirus diseases of animals and birds: comparatives aspects and diagnosis Dionisia bunoi n. g. n. sp., Haemoproteidae parasite du microchiroptè re Hipposideros cyclops au Gabon The chiropteran haemosporidian Polychromophilus melanipherus: A worldwide species complex restricted to the family Many authors suggested that persistence in the absence of pathology or disease appears to be a common characteristic of bat viruses in their natural host population [28, 29] . keywords: afra; bats; belpv; host; paramyxovirus; pcr; rna; species; virus; viruses cache: cord-317244-4su5on6s.txt plain text: cord-317244-4su5on6s.txt item: #497 of 672 id: cord-317779-j67vb7f3 author: Irizarry, Kristopher J. L. title: RNA sequencing demonstrates large-scale temporal dysregulation of gene expression in stimulated macrophages derived from MHC-defined chicken haplotypes date: 2017-08-28 words: 9744 flesch: 37 summary: key: cord-317779-j67vb7f3 authors: Irizarry, Kristopher J. L.; Downs, Eileen; Bryden, Randall; Clark, Jory; Griggs, Lisa; Kopulos, Renee; Boettger, Cynthia M.; Carr, Thomas J.; Keeler, Calvin L.; Collisson, Ellen; Drechsler, Yvonne title: RNA sequencing demonstrates large-scale temporal dysregulation of gene expression in stimulated macrophages derived from MHC-defined chicken haplotypes date: 2017-08-28 journal: PLoS One DOI: 10.1371/journal.pone.0179391 sha: doc_id: 317779 cord_uid: j67vb7f3 Discovering genetic biomarkers associated with disease resistance and enhanced immunity is critical to developing advanced strategies for controlling viral and bacterial infections in different species. These differences in gene expression appear to be regulated by complex epigenetic mechanisms that need further investigation. keywords: b19; b19 cells; b2 cells; birds; cells; data; day; differentiation; expression; gene expression; genes; haplotype; hours; ifnγ; macrophages; stimulation; time cache: cord-317779-j67vb7f3.txt plain text: cord-317779-j67vb7f3.txt item: #498 of 672 id: cord-317912-v2wovcqd author: Akmatov, Manas K. title: Equivalence of Self- and Staff-Collected Nasal Swabs for the Detection of Viral Respiratory Pathogens date: 2012-11-14 words: 3495 flesch: 53 summary: Due to much lower expenses for personnel and travel, selfcollection would be a highly cost-efficient way to obtain diagnostic nasal swabs in medium and large scale population-based studies on ARI epidemiology [3] . The amount of β-actin DNA per swab was higher in the self- than in the staff-collected swabs (p = 0.008). keywords: day; nasal; participants; self; staff; study; swabs cache: cord-317912-v2wovcqd.txt plain text: cord-317912-v2wovcqd.txt item: #499 of 672 id: cord-318008-4s9eoae3 author: Parsons Leigh, Jeanna title: A national cross-sectional survey of public perceptions of the COVID-19 pandemic: Self-reported beliefs, knowledge, and behaviors date: 2020-10-23 words: 5687 flesch: 43 summary: We elected to collect 2,000 questionnaires to allow for regional subgroup analyses and calculated the associated margin of error to be +/-2.2% at a 95% confidence level. Of those who were not self-isolating (n = 1,144), the vast majority (n = 1,083, 95.1%, 95% CI 93.8%-96.4%) reported that they practiced physical distancing always (n = 783, 68.8%, (95% CI 66.0%-71.5%) or often (n = 300, 26.3%, 95% CI 23.7%-28.9%). keywords: covid-19; health; information; pandemic; public; respondents; self; sources; survey cache: cord-318008-4s9eoae3.txt plain text: cord-318008-4s9eoae3.txt item: #500 of 672 id: cord-318614-518giv0m author: Tsai, Jih-Jin title: A fully automated sample-to-answer PCR system for easy and sensitive detection of dengue virus in human serum and mosquitos date: 2019-07-10 words: 4829 flesch: 42 summary: The semi-automated POCKIT combo system includes an automated taco mini for nucleic acid extraction and a POCKIT device for PCR detection. Sample info and test results of mosquito samples with pan-DENV RT-iiPCR on fully automated POCKIT Central system and semi-automated POCKIT combo system. keywords: dengue; denv; detection; extraction; iipcr; pan; pcr; pockit; system; virus cache: cord-318614-518giv0m.txt plain text: cord-318614-518giv0m.txt item: #501 of 672 id: cord-318696-jheb2fnn author: Kesic, Matthew J. title: Exposure to Ozone Modulates Human Airway Protease/Antiprotease Balance Contributing to Increased Influenza A Infection date: 2012-04-09 words: 8666 flesch: 36 summary: This correlates with the increase in protease expression post ozone exposure ( Figure 5B ), viral entry (Figure 4) , and viral replication ( Figure 1C and 1D ). Similarly, by analyzing the apical washes for influenza viral titers 24 h post-infection, we saw a significant increase in viral titers in ozone exposed cells as compared to the control ( Figure 1D ). keywords: cells; cleavage; exposure; expression; figure; infection; influenza; necs; ozone; post; protease; protein; replication; slpi; stress; virus cache: cord-318696-jheb2fnn.txt plain text: cord-318696-jheb2fnn.txt item: #502 of 672 id: cord-318845-w7q5o8wc author: Pendell, Dustin L. title: Economic Assessment of FMDv Releases from the National Bio and Agro Defense Facility date: 2015-06-26 words: 8169 flesch: 45 summary: Unlike previous studies that focused on various alternate mitigation strategies, this study focuses on potential animal disease releases from NBAF. However, consequences of disease outbreaks are inherently dynamic in nature with benefits and costs accruing differently to producers and consumers across time, and this interplay has important policy implications [5] . keywords: animal; beef; costs; disease; fmd; impacts; losses; model; outbreak; quarter; release; states; study; u.s cache: cord-318845-w7q5o8wc.txt plain text: cord-318845-w7q5o8wc.txt item: #503 of 672 id: cord-319190-esjfhztp author: Lu, Xi title: In Vitro Activity of Sodium New Houttuyfonate Alone and in Combination with Oxacillin or Netilmicin against Methicillin-Resistant Staphylococcus aureus date: 2013-07-02 words: 3298 flesch: 38 summary: In time-kill analysis, SNH at 1/2 MIC in combination with oxacillin at 1/128 to 1/64 MIC or netilmicin at 1/8 to 1/2 MIC decreased the viable colonies by ≥2log(10) CFU/mL. CONCLUSIONS/SIGNIFICANCE: SNH demonstrated in vitro antibacterial activity against 103 hospital-associated MRSA isolates. Sodium new houttuyfonate (SNH) is an analogue of houttuynin, the main antibacterial ingredient of Houttuynia cordata Thunb. keywords: antibacterial; antimicrobial; aureus; combinations; mic; mrsa; snh; strains cache: cord-319190-esjfhztp.txt plain text: cord-319190-esjfhztp.txt item: #504 of 672 id: cord-319256-7pyinx1a author: Jin, Xin title: The values of coagulation function in COVID-19 patients date: 2020-10-29 words: 2826 flesch: 43 summary: key: cord-319256-7pyinx1a authors: Jin, Xin; Duan, Yongwei; Bao, Tengfei; Gu, Junjuan; Chen, Yawen; Li, Yuanyuan; Mao, Shi; Chen, Yongfeng; Xie, Wen title: The values of coagulation function in COVID-19 patients date: 2020-10-29 journal: PLoS One DOI: 10.1371/journal.pone.0241329 sha: doc_id: 319256 cord_uid: 7pyinx1a OBJECTIVE: To investigate the blood coagulation function in COVID-19 patients, and the correlation between coagulopathy and disease severity. We analyzed the coagulation function in COVID-19 patients through the data including thrombin-antithrombin complex (TAT), α2-plasmininhibitor-plasmin Complex (PIC), thrombomodulin (TM), t-PA/PAI-1 Complex (t-PAIC), prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), fibrinogen (FIB), thrombin time (TT), D-Dimer (DD), and platelet (PLT). keywords: coagulation; covid-19; disease; paic; patients cache: cord-319256-7pyinx1a.txt plain text: cord-319256-7pyinx1a.txt item: #505 of 672 id: cord-319538-bawzonq1 author: Krause, Martin title: Association between procalcitonin levels and duration of mechanical ventilation in COVID-19 patients date: 2020-09-18 words: 2571 flesch: 28 summary: We aimed to identify if plasma procalcitonin levels on admission are associated with the duration of mechanical ventilation (primary outcome), 28-day mortality, and time to intubation (secondary outcomes) in a cohort of COVID-19 patients requiring mechanical ventilation. key: cord-319538-bawzonq1 authors: Krause, Martin; Douin, David J.; Tran, Timothy T.; Fernandez-Bustamante, Ana; Aftab, Muhammad; Bartels, Karsten title: Association between procalcitonin levels and duration of mechanical ventilation in COVID-19 patients date: 2020-09-18 journal: PLoS One DOI: 10.1371/journal.pone.0239174 sha: doc_id: 319538 cord_uid: bawzonq1 BACKGROUND: Patients diagnosed with COVID-19 frequently require mechanical ventilation. keywords: duration; level; patients; procalcitonin; ventilation cache: cord-319538-bawzonq1.txt plain text: cord-319538-bawzonq1.txt item: #506 of 672 id: cord-319675-mwy3t1ny author: Gu, Li title: Sustained Viremia and High Viral Load in Respiratory Tract Secretions Are Predictors for Death in Immunocompetent Adults with Adenovirus Pneumonia date: 2016-08-17 words: 3087 flesch: 52 summary: At admission (on day 5–7 after illness onset), the patients in fatal cases presented higher initial viral loads in respiratory tract secretions (8.578 ± 2.115 vs 6.263 ± 1.225 Log(10) copies/ml, p = 0.023). For those with positive AdV PCR testing, serial whole blood and respiratory tract samples were collected until death or discharge. keywords: cases; day; load; patients; samples; tract cache: cord-319675-mwy3t1ny.txt plain text: cord-319675-mwy3t1ny.txt item: #507 of 672 id: cord-319706-2e9jrv0s author: Ebinger, Joseph E. title: Pre-existing traits associated with Covid-19 illness severity date: 2020-07-23 words: 4912 flesch: 32 summary: For the total sample of Covid-19 patients, we used parametric tests to compare normally distributed continuous variables and non-normally distributed or categorical variables, respectively. CONCLUSIONS AND RELEVANCE: In our healthcare system, greater Covid-19 illness severity is seen in patients who are older, male, African American, obese, with diabetes, and with greater overall comorbidity burden. keywords: age; care; covid-19; illness; intubation; male; patients; risk; severity; sex cache: cord-319706-2e9jrv0s.txt plain text: cord-319706-2e9jrv0s.txt item: #508 of 672 id: cord-319845-oob2ktnz author: Proença-Modena, José Luiz title: Detection of Human Bocavirus mRNA in Respiratory Secretions Correlates with High Viral Load and Concurrent Diarrhea date: 2011-06-20 words: 5862 flesch: 43 summary: The most frequent clinical diagnoses associated with respiratory HBoV are general upper respiratory tract infections (URTI), bronchiolitis, pneumonia, bronchitis and exacerbation of asthma [2] . A comparison of clinical features between HBoV patients with and without shedding of VP1 mRNA revealed an association of active viral replication with diarrhea (OR = 6.00; 95% CI = 1.15-34.14; p = 0.04) and a clinical diagnosis of URTI (OR = 19.33; 95% CI = 1.82-294.96; p = 0.01). keywords: ari; bocavirus; detection; hbov; human; infections; patients; pcr; samples; study; viruses cache: cord-319845-oob2ktnz.txt plain text: cord-319845-oob2ktnz.txt item: #509 of 672 id: cord-319921-uxtydu60 author: Meli, Marina L. title: Feline Leukemia Virus and Other Pathogens as Important Threats to the Survival of the Critically Endangered Iberian Lynx (Lynx pardinus) date: 2009-03-09 words: 5513 flesch: 42 summary: With the exception of feline immunodeficiency virus (FIV), evidence of infection by all tested feline pathogens was found in Iberian lynxes. Iberian lynxes are confined to two isolated populations in southern Spain in the Doñ ana and Sierra Morena areas, and only 40-50 and 150-200, respectively, are estimated to remain [5, 6, 7] . keywords: animals; cats; feline; felv; iberian; infection; leukemia; lynx; lynxes; pcr; provirus; samples; sequences; virus cache: cord-319921-uxtydu60.txt plain text: cord-319921-uxtydu60.txt item: #510 of 672 id: cord-320091-2lrqubdl author: Badawi, Alaa title: Prevalence of chronic comorbidities in dengue fever and West Nile virus: A systematic review and meta-analysis date: 2018-07-10 words: 8525 flesch: 44 summary: ORs of severe flavivirus diseases were about 2 to 4 in infected patients with comorbidities such as diabetes, hypertension and heart diseases. Currently, our knowledge of the host-related factors that influence the pathogenesis of severe disease is inadequate to allow prediction of who will develop severe clinical illness. keywords: cases; comorbidities; dengue; denv; diabetes; diseases; fever; flavivirus; infection; patients; prevalence; risk; studies; study; west; wnv cache: cord-320091-2lrqubdl.txt plain text: cord-320091-2lrqubdl.txt item: #511 of 672 id: cord-320466-l7017jis author: Akgun, Emel title: Proteins associated with neutrophil degranulation are upregulated in nasopharyngeal swabs from SARS-CoV-2 patients date: 2020-10-20 words: 3726 flesch: 36 summary: The abundance of these proteins were found to be increased in COVID-19 positive patient samples compared to negative ones. NETs have pathogen killing properties and include strands of DNA wrapped with histones and are enriched with neutrophil proteins like MPO, ELANE, PRTN3 and AZU1 keywords: covid-19; elane; infection; inflammation; mpo; neutrophil; patients; proteins; prtn3; samples; sars cache: cord-320466-l7017jis.txt plain text: cord-320466-l7017jis.txt item: #512 of 672 id: cord-320938-f526k9q1 author: Chen, Hongjun title: Partial and Full PCR-Based Reverse Genetics Strategy for Influenza Viruses date: 2012-09-28 words: 8653 flesch: 51 summary: key: cord-320938-f526k9q1 authors: Chen, Hongjun; Ye, Jianqiang; Xu, Kemin; Angel, Matthew; Shao, Hongxia; Ferrero, Andrea; Sutton, Troy; Perez, Daniel R. title: Partial and Full PCR-Based Reverse Genetics Strategy for Influenza Viruses date: 2012-09-28 journal: PLoS One DOI: 10.1371/journal.pone.0046378 sha: doc_id: 320938 cord_uid: f526k9q1 Since 1999, plasmid-based reverse genetics (RG) systems have revolutionized the way influenza viruses are studied. In addition, influenza viruses were recovered from a full set of Flu PCR amplicons without the use of plasmids. keywords: amplicons; cells; fig; influenza; lane; pcr; pcr amplicons; pdm; plasmid; pol1; pr8; primer; virus; viruses cache: cord-320938-f526k9q1.txt plain text: cord-320938-f526k9q1.txt item: #513 of 672 id: cord-321438-llnqzkqt author: Ma, Ruili title: Proteome Profile of Swine Testicular Cells Infected with Porcine Transmissible Gastroenteritis Coronavirus date: 2014-10-21 words: 7135 flesch: 36 summary: [12] , while ORF7 may interact with host cell proteins and play a role in TGEV replication Although we have some knowledge concerning the translation and function of these viral proteins, the interactions that occur between these proteins and host cell proteins are not fully understood. keywords: analysis; cells; changes; coronavirus; expression; gene; host; hpi; infected; infection; itraq; proteins; replication; response; tgev; time; virus cache: cord-321438-llnqzkqt.txt plain text: cord-321438-llnqzkqt.txt item: #514 of 672 id: cord-321624-z2mntwef author: Kowitdamrong, Ekasit title: Antibody responses to SARS-CoV-2 in patients with differing severities of coronavirus disease 2019 date: 2020-10-09 words: 3391 flesch: 51 summary: Supporting information S1 Clinical features of patients infected with 2019 novel coronavirus in Wuhan A novel coronavirus outbreak of global health concern Early transmission patterns of coronavirus disease 2019 (COVID-19) in travellers from Wuhan to Thailand Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR SARS-CoV-2 antibody testing-questions to be asked Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19) Antibody responses to SARS-CoV-2 in patients with COVID-19 Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease Patients Clinical performance of different SARS-CoV-2 IgG antibody tests Evaluation of two automated and three rapid lateral flow immunoassays for the detection of anti-SARS-CoV-2 antibodies Assessment of SARS-CoV-2 serological tests for the diagnosis of COVID-19 through the evaluation of three immunoassays: Two automated immunoassays (Euroimmun and Abbott) and one rapid lateral flow immunoassay (NG Biotech) Performance Characteristics of Four High-Throughput Immunoassays for Detection of IgG Antibodies against SARS-CoV-2 Clinical Performance of Two SARS-CoV-2 Serologic Assays Diagnostic performance of seven rapid IgG/IgM antibody tests and the Euroimmun IgA/IgG ELISA in COVID-19 patients Neutralizing Antibodies Responses to SARS-CoV-2 in COVID-19 Inpatients and Convalescent Patients Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population. In the present study, 30% of COVID-19 patients developed positive IgA antibodies very early, within 3 days after the onset of symptoms. keywords: cov-2; group; iga; igg; patients; sars; symptoms cache: cord-321624-z2mntwef.txt plain text: cord-321624-z2mntwef.txt item: #515 of 672 id: cord-321705-6a7avlro author: Hou, Tianya title: Social support and mental health among health care workers during Coronavirus Disease 2019 outbreak: A moderated mediation model date: 2020-05-29 words: 5378 flesch: 43 summary: Personality & Individual Differences Relationships Among Positive Emotions, Coping, Resilience and Mental Health Longitudinal study of resilience and mental health in marines leaving military service Mental Health and Resilience in HIV/AIDS-Affected Children: A Review of the Literature and Recommendations for Future Research The impact of psychological resilience on Army active duty military wives' mental and physical health Annual Research Review: Resilience and mental health in children and adolescents living in areas of armed conflict-a systematic review of findings in low-and middle-income countries Understanding the influence of resilience for people with a lived experience of mental illness: A self-determination theory perspective Association between social support and healthrelated quality of life among Chinese rural elders in nursing homes: the mediating role of resilience Depression Treatment in Older Adult Veterans The Prevalence and Predictors of Mental Health Treatment Services in a National Sample of Depressed Veterans Attitudes towards mental health care in younger and older adults: Similarities and differences Age as a predictive factor of mental health service use among adults with depression and/or anxiety disorder receiving care through the Veterans Health Administration Effects of Resilience Training on the Reduction of Stress and Depression among Dutch Workers. key: cord-321705-6a7avlro authors: Hou, Tianya; Zhang, Taiquan; Cai, Wenpeng; Song, Xiangrui; Chen, Aibin; Deng, Guanghui; Ni, Chunyan title: Social support and mental health among health care workers during Coronavirus Disease 2019 outbreak: A moderated mediation model date: 2020-05-29 journal: PLoS One DOI: 10.1371/journal.pone.0233831 sha: doc_id: 321705 cord_uid: 6a7avlro PURPOSES: During the outbreak of Coronavirus Disease 2019 (COVID-19) all over the world, the mental health conditions of health care workers are of great importance to ensure the efficiency of rescue operations. keywords: adults; care; care workers; health; health care; middle; resilience; study; support; workers cache: cord-321705-6a7avlro.txt plain text: cord-321705-6a7avlro.txt item: #516 of 672 id: cord-321834-n5w88l23 author: Huang, Cheng-Yang title: Inhibition of a Putative Dihydropyrimidinase from Pseudomonas aeruginosa PAO1 by Flavonoids and Substrates of Cyclic Amidohydrolases date: 2015-05-19 words: 5265 flesch: 43 summary: Although we found that dihydroorotate, 5-hydantoin acetic acid, and acetohydroxamate inhibited dihydropyrimidinase activity, their IC 50 values were at the millimolar range and higher than the K m values of dihydropyrimidinase, which were insufficient as potent inhibitors. To assess whether allantoin and dihydroorotate are dihydropyrimidinase inhibitors, allantoin and dihydroorotate were individually included in the standard assay using 5-propylhydantoin (Fig 2A) or dihydrouracil ( Fig 2B) as a substrate. keywords: activity; aeruginosa; dihydromyricetin; dihydropyrimidinase; dihydrouracil; fig; flavonoids; hydantoin; myricetin; structure; substrate cache: cord-321834-n5w88l23.txt plain text: cord-321834-n5w88l23.txt item: #517 of 672 id: cord-321855-7b1c2xdh author: Alshami, Alanoud title: Silent disease and loss of taste and smell are common manifestations of SARS-COV-2 infection in a quarantine facility: Saudi Arabia date: 2020-10-30 words: 3382 flesch: 53 summary: A recent study has shown that the viral load detected in asymptomatic patients was similar to the viral load of symptomatic patients suggesting that asymptomatic patients can also transmit the disease This regulation has helped us to better understand the prevalence of SARS-COV-2 infection in asymptomatic patients. keywords: asymptomatic; disease; patients; residents; study; symptoms cache: cord-321855-7b1c2xdh.txt plain text: cord-321855-7b1c2xdh.txt item: #518 of 672 id: cord-322414-dpx191xh author: Harke, Nina N. title: To defer or not to defer? A German longitudinal multicentric assessment of clinical practice in urology during the COVID-19 pandemic date: 2020-09-15 words: 3778 flesch: 39 summary: This disadvantageous postoperative course for COVID-19 positive patients was also supported by Nepogodiev [13] . Accordingly, only a minority of the respondents reported COVID-19 positive patients in their departments in March and April. keywords: april; cases; covid-19; march; patients; surgeries; surgery; week cache: cord-322414-dpx191xh.txt plain text: cord-322414-dpx191xh.txt item: #519 of 672 id: cord-322446-ddv86eoy author: Sharma, Kulbhushan title: SARS-CoV 9b Protein Diffuses into Nucleus, Undergoes Active Crm1 Mediated Nucleocytoplasmic Export and Triggers Apoptosis When Retained in the Nucleus date: 2011-05-27 words: 8463 flesch: 53 summary: Typical infected cells showed numerous nuclear foci of 9b protein by 36 h post-infection, as well as extensive, larger areas of cytoplasmic inclusions ( Fig. 1a and 1b) . Lower panels: An in-vitro transport assay for 9b protein performed in the presence of WGA. keywords: cells; cov; export; fig; hrs; localization; nes; nuclear; nucleus; panel; protein; sars; transport cache: cord-322446-ddv86eoy.txt plain text: cord-322446-ddv86eoy.txt item: #520 of 672 id: cord-322533-adqqm0n9 author: Sha, Dexuan title: Spatiotemporal analysis of medical resource deficiencies in the U.S. under COVID-19 pandemic date: 2020-10-14 words: 5194 flesch: 44 summary: [9, 10] . Are U.S. medical resources enough to handle the worst scenario during this crisis? In this study, we (1) conduct a medical data analysis, and re-evaluate the spatial distribution of medical resource features (hospital beds, ICU beds, and CCS) at county level; (2) develop two Medical Resource Deficiency Indices (MRDI and MRDI d ) by linking positive COVID-19 infections and local medical resources to measure local medical burden; and (3) develop a data-driven dynamic spatiotemporal framework to visualize and analyze the MRDI /MRDI keywords: beds; care; county; covid-19; data; icu; level; mrdi; number; patients; u.s cache: cord-322533-adqqm0n9.txt plain text: cord-322533-adqqm0n9.txt item: #521 of 672 id: cord-322827-h33su548 author: Guan, Lili title: Unlocking Patients with Mental Disorders Who Were in Restraints at Home: A National Follow-Up Study of China’s New Public Mental Health Initiatives date: 2015-04-07 words: 5069 flesch: 47 summary: Releasing the mentally ill from physical restraint Global mental health: a failure of humanity A qualitative study of religious practices by chronic mentally ill and their caregivers in South India WPA guidance on steps, obstacles and mistakes to avoid in the implementation of community mental health care Scale up of services for mental health in low-income and middle-income countries Resources for mental health: scarcity, inequity, and inefficiency Barriers to improvement of mental health services in low-income and middle-income countries Treatment and prevention of mental disorders in low-income and middle-income countries Recognizing the gap between the population's needs for mental health care and the level of resources and services available [2] keywords: care; family; health; patients; program; treatment; unlocking cache: cord-322827-h33su548.txt plain text: cord-322827-h33su548.txt item: #522 of 672 id: cord-323133-gdg50omp author: Buzatto, G. P. title: The pathogens profile in children with otitis media with effusion and adenoid hypertrophy date: 2017-02-23 words: 4245 flesch: 36 summary: S. pneumoniae and M. catarrhalis were detected more often in middle ear washes from OME patients than controls. Although total virus detection was not statistically different from controls at the middle ear washes (p = 0.065), adenovirus was detected in higher proportions in adenoid samples of OME patients than controls (p = 0.019). keywords: adenoid; bacteria; children; detection; ear; media; middle; ome; otitis; patients cache: cord-323133-gdg50omp.txt plain text: cord-323133-gdg50omp.txt item: #523 of 672 id: cord-323185-n0rubc72 author: Varshney, Bhavna title: SARS Coronavirus 3b Accessory Protein Modulates Transcriptional Activity of RUNX1b date: 2012-01-12 words: 5707 flesch: 45 summary: Results depicted a 1.5 fold increase in phosphorylated RUNX1b levels in 3b transfected cells compared to control transfected cells (Fig. 5A ). ChIP results from 3b transfected cells using anti-HA depicted co-immunoprecipitation of the IL2 promoter region containing RUNX1 binding site but not from mock transfected cells (Fig. 3) . keywords: activity; acute; binding; cells; coronavirus; cov; human; il2; promoter; protein; runx1b; sars; transcription cache: cord-323185-n0rubc72.txt plain text: cord-323185-n0rubc72.txt item: #524 of 672 id: cord-323330-ghwhgkdm author: Ekundayo, Temitope Cyrus title: A global bibliometric analysis of Plesiomonas-related research (1990 – 2017) date: 2018-11-29 words: 4904 flesch: 35 summary: The aim of the survey was to evaluate international participation in P. shigelloides research-with a special interest in regions where Plesiomonas infections have higher prevalence rates (i.e., Africa and Southeast Asia)-in order to address knowledge gaps and provide a resource that can help identify present and future research priorities. The scientific output related to P. shigelloides research by Lotka's law showed a beta coefficient and constant of 2.30 and 0.44, Table 2 shows the top 20 most productive authors in the field. keywords: analysis; articles; authors; countries; keywords; network; plesiomonas; research; shigelloides cache: cord-323330-ghwhgkdm.txt plain text: cord-323330-ghwhgkdm.txt item: #525 of 672 id: cord-323433-9km824uh author: van den Wijngaard, Cees C. title: Syndromic Surveillance for Local Outbreaks of Lower-Respiratory Infections: Would It Work? date: 2010-04-29 words: 4791 flesch: 44 summary: The total number of detected clusters and signals is presented, for the non-restrictive parameter settings on space and time (A), for the settings with a maximum time window of 7 weeks (B), and for the settings with a maximum radius of 25 km (C). As a threshold value for the significance of cluster signals, we used a threshold of recurrence intervals $1 year, and only evaluated the LRI clusters that were above this threshold. keywords: clusters; data; disease; lri; outbreaks; signals; surveillance; time cache: cord-323433-9km824uh.txt plain text: cord-323433-9km824uh.txt item: #526 of 672 id: cord-324091-nljd2ok1 author: Gordon, Jennifer L. title: The psychological impact of fertility treatment suspensions during the COVID-19 pandemic date: 2020-09-18 words: 4515 flesch: 42 summary: Participants completed a battery of questionnaires assessing depressive symptoms, perceived mental health impact, and change in quality of life related to treatment suspensions. Neither age, years of education, annual income, nor the number of children a woman had were correlated with either change in quality of life or perceived mental health impact (p >.05). keywords: health; impact; infertility; life; quality; suspensions; treatment cache: cord-324091-nljd2ok1.txt plain text: cord-324091-nljd2ok1.txt item: #527 of 672 id: cord-324359-88vy3dre author: Kamara, Foday Mamoud title: How villagers in central Sierra Leone understand infection risks under threat of Covid-19 date: 2020-06-24 words: 2951 flesch: 56 summary: key: cord-324359-88vy3dre authors: Kamara, Foday Mamoud; Mokuwa, Esther Yei; Richards, Paul title: How villagers in central Sierra Leone understand infection risks under threat of Covid-19 date: 2020-06-24 journal: PLoS One DOI: 10.1371/journal.pone.0235108 sha: doc_id: 324359 cord_uid: 88vy3dre BACKGROUND: Concern has been expressed over how well Africa is prepared to cope with the pandemic of Covid-19. We assessed understanding of infection risks via an experimental game. keywords: covid-19; disease; game; infection; players; stones cache: cord-324359-88vy3dre.txt plain text: cord-324359-88vy3dre.txt item: #528 of 672 id: cord-324405-6uanhe2p author: Burke, Rachel M. title: Enhanced contact investigations for nine early travel-related cases of SARS-CoV-2 in the United States date: 2020-09-02 words: 6625 flesch: 37 summary: The results of these investigations suggest that the risk of becoming infected with SARS--CoV-2 is high among close household contacts of confirmed COVID-19 patients, especially significant others. In response to the first cases identified in the United States, close contacts of confirmed COVID-19 cases were investigated to enable early identification and isolation of additional cases and to learn more about risk factors for transmission. keywords: case; case patient; contacts; cov-2; covid-19; exposure; household; patient; samples; sars; travel cache: cord-324405-6uanhe2p.txt plain text: cord-324405-6uanhe2p.txt item: #529 of 672 id: cord-324410-be2ith3z author: Wang, Qi title: Accurate Reproduction of 161 Small-Molecule Complex Crystal Structures using the EUDOC Program: Expanding the Use of EUDOC to Supramolecular Chemistry date: 2007-06-13 words: 3776 flesch: 42 summary: These results show that the influence of crystal packing or crystal environment on crystal structures of guest-host complexes is significant, which is consistent with the reported influence of crystal packing on protein structures To expand the application of the EUDOC program to supramolecular chemistry, we tested its ability to reproduce crystal structures of small-molecule complexes. keywords: complexes; crystal; crystal structures; eudoc; guest; host; program; structures cache: cord-324410-be2ith3z.txt plain text: cord-324410-be2ith3z.txt item: #530 of 672 id: cord-325113-sou8xyld author: Kuiper, Johannes W. P. title: Detection of SARS-CoV-2 from raw patient samples by coupled high temperature reverse transcription and amplification date: 2020-11-02 words: 4980 flesch: 43 summary: A RNA-and DNA-reading heat-stable polymerase reverse transcribes and amplifies viral RNA Evidence of an acute SARS-CoV-2 infection depends on the detection of viral RNA species in patient samples, which necessitates reverse transcription of RNA followed by PCR amplification of the resulting DNA. When 5000 genome equivalents of the purified, in vitro transcribed viral RNA was used as a PCR template for a generic, heat-stable DNA-dependent DNA polymerase (Taq DNA polymerase) keywords: dna; fig; patient; pcr; polymerase; rna; samples; sars; temperature; volcano3 cache: cord-325113-sou8xyld.txt plain text: cord-325113-sou8xyld.txt item: #531 of 672 id: cord-326011-5rmhjbri author: Cui, Dawei title: Clinical and Epidemiologic Characteristics of Hospitalized Patients with Laboratory-Confirmed Respiratory Syncytial Virus Infection in Eastern China between 2009 and 2013: A Retrospective Study date: 2016-11-01 words: 3508 flesch: 39 summary: However, few studies regarding the epidemiology of hospitalizations for RSV infection have been performed previously in China. Moreover, young children aged <5 years (89.1%, 932/1046), particularly young infants aged <1 year (43.3%, 453/1046), represented the highest proportion of patients with RSV infections. keywords: children; china; infection; patients; rsv; virus cache: cord-326011-5rmhjbri.txt plain text: cord-326011-5rmhjbri.txt item: #532 of 672 id: cord-326568-twv2i3fb author: Bruminhent, Jackrapong title: Clinical characteristics and risk factors for coronavirus disease 2019 (COVID-19) among patients under investigation in Thailand date: 2020-09-15 words: 4407 flesch: 45 summary: COVID-19 patients can present as asymptomatic, mild upper respiratory tract disease or potentially severe pneumonia. Although there was a previous case series of COVID-19 patients who were hospitalized [9] , there has been no study focused on this population. keywords: case; cov-2; covid-19; infection; patients; puis; risk; thailand cache: cord-326568-twv2i3fb.txt plain text: cord-326568-twv2i3fb.txt item: #533 of 672 id: cord-327199-ggomuomb author: Moerdyk-Schauwecker, Megan title: Cellular Proteins Associated with the Interior and Exterior of Vesicular Stomatitis Virus Virions date: 2014-08-08 words: 6429 flesch: 35 summary: mature and extracellular enveloped virions Protein composition of the vaccinia virus mature virion Identification of proteins associated with murine gammaherpesvirus 68 virions Proteomic analysis of pathogenic and attenuated alcelaphine herpesvirus 1 Proteins of purified Epstein-Barr virus Identification of proteins associated with murine cytomegalovirus virions Comprehensive characterization of extracellular herpes simplex virus type 1 virions Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome Virion proteins of Kaposi's sarcomaassociated herpesvirus Proteomic characterization of pseudorabies virus extracellular virions Cellular proteins in influenza virus particles Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3 Proteomic analysis of purified coronavirus infectious bronchitis virus particles Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages Proteomic analysis of human immunodeficiency virus using liquid chromatography/tandem mass spectrometry effectively distinguishes specific incorporated host proteins Identification of host proteins associated with retroviral vector particles by proteomic analysis of highly purified vector preparations Distinct host cell proteins incorporated by SIV replicating in CD4+ T cells from natural disease resistant versus non-natural disease susceptible hosts Protein analysis of purified respiratory syncytial virus particles reveals an important role for heat shock protein 90 in virus particle assembly Proteomic analysis of purified Newcastle disease virus particles Proteomics of the Autographa californica nucleopolyhedrovirus budded virions Correlation between structure, protein composition, morphogenesis and cytopathology of Glossina pallidipes salivary gland hypertrophy virus Profiling of cellular proteins in porcine reproductive and respiratory syndrome virus virions by proteomics analysis Analysis of virion associated host proteins in vesicular stomatitis virus using a proteomics approach A single amino acid change in the L-polymerase protein of vesicular stomatitis virus completely abolishes viral mRNA cap methylation Recombinant vesicular stomatitis viruses from DNA The lipidomes of vesicular stomatitis virus, semliki forest virus, and the host plasma membrane analyzed by quantitative shotgun mass spectrometry Specific interactions of vesicular stomatitis virus L and NS proteins with heterologous genome ribonucleoprotein template lead to mRNA synthesis in vitro Systematic characterization of nuclear proteome during apoptosis: a quantitative proteomic study by differential extraction and stable isotope labeling Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search Code developments to improve the efficiency of automated MS/MS spectra interpretation Mining genomes: correlating tandem mass spectra of modified and unmodified peptides to sequences in nucleotide databases Future prospects for the analysis of complex biological systems using micro-column liquid chromatography-electrospray tandem mass spectrometry Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists Biophysical studies of vesicular stomatitis virus Structural domains of vesicular stomatitis virus. Here we aimed to determine the localization of host proteins within the VSV virions by analyzing: i) whole VSV virions; and ii) whole VSV virions treated with Proteinase K to remove all proteins outside the viral envelope. keywords: analysis; budding; cell; host; human; prok; proteins; rnp; stomatitis; type; virions; virus; viruses; vsv cache: cord-327199-ggomuomb.txt plain text: cord-327199-ggomuomb.txt item: #534 of 672 id: cord-327257-doygrgrc author: Zhu, Jocelyn title: Deep transfer learning artificial intelligence accurately stages COVID-19 lung disease severity on portable chest radiographs date: 2020-07-28 words: 3689 flesch: 48 summary: Deep-learning convolutional neural network (CNN) was used to predict lung disease severity scores. [12, 13] with an additional regression layer was utilized to predict disease severity scores of CXR on a graded scale. keywords: covid-19; cxr; disease; learning; lung; scores; severity; transfer cache: cord-327257-doygrgrc.txt plain text: cord-327257-doygrgrc.txt item: #535 of 672 id: cord-327534-f2wvh6la author: Zhou, Peng title: IRF7 in the Australian Black Flying Fox, Pteropus alecto: Evidence for a Unique Expression Pattern and Functional Conservation date: 2014-08-06 words: 7755 flesch: 48 summary: Pictures show co-localisation of bat IRF7 or bat IRF3 with bat MyD88 in PaKiT03 cells and human IRF7 or human IRF3 with human MyD88 in HEK293T cells. Sequence differences in the MyD88 binding domain of bat and human IRF7 led to the hypothesis that there may be functional differences in the activation of bat IRF7 and the regulation of the IFN response that may contribute to the ability of bats to resist the clinical outcomes of viral infection. keywords: alecto; bat; bats; binding; cells; expression; figure; human; ifn; immune; irf3; irf7; myd88; promoter; response cache: cord-327534-f2wvh6la.txt plain text: cord-327534-f2wvh6la.txt item: #536 of 672 id: cord-328206-iylw1bvw author: Yu, Daojun title: Simultaneous Detection and Differentiation of Human Papillomavirus Genotypes 6, 11, 16 and 18 by AllGlo Quadruplex Quantitative PCR date: 2012-11-09 words: 4073 flesch: 42 summary: In addition, AllGlo probe quadruplex fluorescence quantitative PCR also has the advantages of relatively high throughput, time savings, simple operation, and lower cost, which are key factors that are needed in order to be qualified for clinical applications. AllGlo quadruplex quantitative PCR in a single tube has the advantages of relatively high throughput, good reproducibility, high sensitivity, high specificity, and a wide linear range of detection. keywords: allglo; detection; dna; fluorescence; hpv; pcr; probe; qpcr; quadruplex; test cache: cord-328206-iylw1bvw.txt plain text: cord-328206-iylw1bvw.txt item: #537 of 672 id: cord-328627-cf8f71dr author: Jando, Julia title: Expression and regulation of the neutral amino acid transporter B(0)AT1 in rat small intestine date: 2017-09-15 words: 8985 flesch: 45 summary: Additionally, plasma levels of branched-chain amino acids were elevated under high protein and amino acid diet. Based on the fact that protein and neutral amino acid availability fluctuates and that not much is yet known about the dietary regulation of intestinal amino acid transporters, we tested the hypothesis that B 0 AT1 function and expression in rat small intestine is acutely regulated by amino acid loads and/or chronically by diets. keywords: ace2; acid; amino; at1; diet; distal; expression; intestine; jejunum; protein; rats; transport cache: cord-328627-cf8f71dr.txt plain text: cord-328627-cf8f71dr.txt item: #538 of 672 id: cord-328633-c31xsyeo author: Moser, Michael J. title: Thermostable DNA Polymerase from a Viral Metagenome Is a Potent RT-PCR Enzyme date: 2012-06-04 words: 7878 flesch: 48 summary: The AMV and MMLV had higher RT activity at 37uC while the 3173 Pol RT was much more active at 65uC using the fluorogenic incorporation assay ( Figure 3A ). Soluble proteins were collected from the supernatant after centrifugation at 11,000 rcf for 10 minutes and assayed for DNA Pol activity based on their ability to extend a 59 fluorescently labeled oligonucleotide primer. keywords: activity; amplification; dna; enzyme; exonuclease; fidelity; figure; mmlv; ms2; pcr; pol; polymerase; primer; reverse; rna; step; taq; target cache: cord-328633-c31xsyeo.txt plain text: cord-328633-c31xsyeo.txt item: #539 of 672 id: cord-329223-f84gjxm1 author: Kouokam, Joseph Calvin title: Investigation of Griffithsin's Interactions with Human Cells Confirms Its Outstanding Safety and Efficacy Profile as a Microbicide Candidate date: 2011-08-02 words: 8854 flesch: 42 summary: In this work we expanded the safety studies to include analyses of off-target effects derived from GRFT binding cell surface oligomannose glycans on human PBMC as well as characterized ectocervical, endocervical and vaginal keratinocyte cell lines End1/E6E7, Ect1/E6E7 and VK2E6E7, which were originally established from normal human endocervical, ectocervical, and vaginal epithelia, respectively, and immortalized by expression of human papillomavirus 16/E6E7 In summary, our data provide further evidence that GRFT, an exceptionally potent antiviral lectin, has very minor effects on the molecular physiology of human cells. keywords: activity; antiviral; binding; cell; cona; data; e6e7; expression; fig; grft; human; lectins; lines; pbmc; pbs; surface; treatment cache: cord-329223-f84gjxm1.txt plain text: cord-329223-f84gjxm1.txt item: #540 of 672 id: cord-329468-vjsurl60 author: Okino, Cintia Hiromi title: Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles date: 2017-02-15 words: 5854 flesch: 41 summary: In contrast, in the current study an unexpected suppressive effect in the TLR7 gene expression was observed only during the early phase of IBV B isolate infection (1dpi), as the transcripts of this gene were found 5 times downregulated. Prevention of IBV infection is currently achieved through vaccination, especially by attenuated viral vaccines, suggesting that local mucosal immunity is essential for induction of effective protection against disease [7, 8, 9] . keywords: chickens; expression; genes; group; ibv; immune; infection; isolate; responses; samples; tracheal; virus cache: cord-329468-vjsurl60.txt plain text: cord-329468-vjsurl60.txt item: #541 of 672 id: cord-329727-h47q76y8 author: Sisó-Almirall, Antoni title: Prognostic factors in Spanish COVID-19 patients: A case series from Barcelona date: 2020-08-21 words: 3445 flesch: 48 summary: This study summarizes the clinical, biological and radiological characteristics, evolution and prognostic factors of patients with COVID-19 disease in primary and community healthcare. A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe Clinical presentation and outcome across age categories among patients with COVID-19 admitted to a Spanish Emergency Department Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area Clinical Characteristics of Covid-19 in New York City Utility of hyposmia and hypogeusia for the diagnosis of COVID-19 COVID-19)-United States The Italian coronavirus disease 2019 outbreak: recommendations from clinical practice Impact of low dose tocilizumab on mortality rate in patients with COVID-19 related pneumonia keywords: 95%ci; admission; covid-19; death; icu; patients cache: cord-329727-h47q76y8.txt plain text: cord-329727-h47q76y8.txt item: #542 of 672 id: cord-329999-flzqm3wh author: Buchanan, Tom title: Why do people spread false information online? The effects of message and viewer characteristics on self-reported likelihood of sharing social media disinformation date: 2020-10-07 words: 13823 flesch: 47 summary: Social media disinformation is very widely used as a tool of influence: computational propaganda has been described as a pervasive and ubiquitous part of modern everyday life [8] . Having shared material known to be untrue at the time (Table 6 ) was significantly predicted by lower Agreeableness and lower age. keywords: analysis; disinformation; facebook; likelihood; literacy; material; media; participants; people; sharing; stories; studies; study cache: cord-329999-flzqm3wh.txt plain text: cord-329999-flzqm3wh.txt item: #543 of 672 id: cord-330079-pdaowkop author: Xu, Lin title: Surveillance and Genome Analysis of Human Bocavirus in Patients with Respiratory Infection in Guangzhou, China date: 2012-09-11 words: 4479 flesch: 44 summary: Many reports of adult HBoV infection enrolled no more than 100 samples [2, 8, 12, 29, 30] . In contrast, HBoV positive adults were mainly diagnosed as acute upper respiratory tract infection (AURI) ( Table 3) . keywords: bocavirus; children; hbov; human; infection; patients; pcr; strains; virus cache: cord-330079-pdaowkop.txt plain text: cord-330079-pdaowkop.txt item: #544 of 672 id: cord-330110-pamxy4av author: Teissier, Elodie title: Mechanism of Inhibition of Enveloped Virus Membrane Fusion by the Antiviral Drug Arbidol date: 2011-01-25 words: 9290 flesch: 43 summary: This could result in conformational rearrangements and, in the context of Arb fusion inhibition, aromatic residues might consequently become more or less accessible to Arb molecules present in their vicinity. Arb concentration in solution was measured at 280 nm in the supernatant (Arb extinction coefficient = 9510 M 21 .cm 21 ). keywords: arb; aromatic; binding; entry; figure; fluorescence; fusion; hcv; hcvpp; hepatitis; lipid; liposomes; membrane; peptides; protein; residues; virus cache: cord-330110-pamxy4av.txt plain text: cord-330110-pamxy4av.txt item: #545 of 672 id: cord-330537-xz0wt1sz author: Biermann, Olivia title: Active case-finding policy development, implementation and scale-up in high-burden countries: A mixed-methods survey with National Tuberculosis Programme managers and document review date: 2020-10-28 words: 5670 flesch: 47 summary: NTP managers considered the national governments the most powerful stakeholder for ACF policy development, while sub-national actors were perceived most powerful for ACF policy implementation. The aim of this study was to describe attitudes of NTP managers related to ACF policy development, implementation and scale-up in the 30 high-burden countries, which potentially impact the development and implementation of national ACF policies. keywords: acf; countries; development; evidence; health; implementation; managers; ntp; policy cache: cord-330537-xz0wt1sz.txt plain text: cord-330537-xz0wt1sz.txt item: #546 of 672 id: cord-330749-xt4aa2ur author: Schilling, Stefan title: Isolation Facilities for Highly Infectious Diseases in Europe – A Cross-Sectional Analysis in 16 Countries date: 2014-10-28 words: 4126 flesch: 35 summary: The study presented was set up to compare the operational management, resources, and technical equipment among European isolation facilities. Consensus statements on the operational management of isolation facilities have been published recently. keywords: care; countries; data; diseases; equipment; european; facilities; isolation cache: cord-330749-xt4aa2ur.txt plain text: cord-330749-xt4aa2ur.txt item: #547 of 672 id: cord-331652-oc5s1if2 author: Trudeau, Michaela P. title: Comparison of Thermal and Non-Thermal Processing of Swine Feed and the Use of Selected Feed Additives on Inactivation of Porcine Epidemic Diarrhea Virus (PEDV) date: 2016-06-24 words: 5999 flesch: 49 summary: Feed samples were spiked with PEDV and then heated to 120–145°C for up to 30 min or irradiated at 0–50 kGy. Another set of feed samples spiked with PEDV and mixed with Ultracid P (Nutriad), Activate DA (Novus International), KEM-GEST (Kemin Agrifood), Acid Booster (Agri-Nutrition), sugar or salt was incubated at room temperature (~25°C) for up to 21 days. keywords: additives; feed; log; pedv; processing; survival; swine; temperature; virus cache: cord-331652-oc5s1if2.txt plain text: cord-331652-oc5s1if2.txt item: #548 of 672 id: cord-331885-8zmuhebu author: Xu, Xiuyan title: Risk factor analysis combined with deep learning in the risk assessment of overseas investment of enterprises date: 2020-10-02 words: 3796 flesch: 37 summary: Considering the characteristics of investment risk assessment, DNN is applied to the construction of the enterprise overseas investment risk assessment model. Meanwhile, the assessment of overseas investment risks is less researched, let alone the applications of deep learning methods in overseas investment risk assessment. keywords: assessment; enterprises; investment; investment risk; learning; model; overseas; resources; risk; risk assessment cache: cord-331885-8zmuhebu.txt plain text: cord-331885-8zmuhebu.txt item: #549 of 672 id: cord-332922-2qjae0x7 author: Mbuvha, Rendani title: Bayesian inference of COVID-19 spreading rates in South Africa date: 2020-08-05 words: 3225 flesch: 48 summary: We follow the framework of [6] to perform Bayesian inference for model parameters on the South African COVID-19 data. The posterior inference is governed by Bayes theorem as follows: Where P(W|D, M) is the posterior distribution of a vector of model parameters (W) given the model(M) and observed data(D), P(D|W, M) is the data likelihood and P(D) is the evidence. keywords: change; data; inference; model; seir; sir; trajectory cache: cord-332922-2qjae0x7.txt plain text: cord-332922-2qjae0x7.txt item: #550 of 672 id: cord-333208-tibtngy8 author: Muñoz-Moreno, Raquel title: Antiviral Role of IFITM Proteins in African Swine Fever Virus Infection date: 2016-04-26 words: 5875 flesch: 42 summary: Expression of IFITM1, 2 and 3 reduced virus infectivity in Vero cells, with IFITM2 and IFITM3 having an impact on viral entry/uncoating. The role of IFITM2 in the inhibition of ASFV in Vero cells could be related to impaired endocytosis-mediated viral entry and alterations in the cholesterol efflux, suggesting that IFITM2 is acting at the late endosome, preventing the decapsidation stage of ASFV. keywords: asfv; cells; cholesterol; endosomal; entry; expression; fig; ifitm2; ifn; infection; membrane; protein; vero; virus cache: cord-333208-tibtngy8.txt plain text: cord-333208-tibtngy8.txt item: #551 of 672 id: cord-333248-5342lyeu author: Elenius, Varpu title: The relationship of serum vitamins A, D, E and LL-37 levels with allergic status, tonsillar virus detection and immune response date: 2017-02-24 words: 3314 flesch: 39 summary: Higher vitamin E levels were associated with lower IL-28 expression (P = 0.016) We found that higher bioavailable 25(OH)D levels were associated with lower prevalence of allergic rhinitis and atopy, higher vitamin E levels with lower prevalence of self-reported allergy, and higher vitamin A showed borderline significance for an association with less respiratory virus detections. keywords: expression; fig; levels; ll-37; serum; vitamin cache: cord-333248-5342lyeu.txt plain text: cord-333248-5342lyeu.txt item: #552 of 672 id: cord-333413-8buawes0 author: Liebing, J. title: Health status of free-ranging ring-necked pheasant chicks (Phasianus colchicus) in North-Western Germany date: 2020-06-16 words: 5556 flesch: 47 summary: Based on these findings, our study focused on pheasant chicks up to eleven weeks of age. Previous studies on pheasants indicated that the most sensitive age class for infectious diseases was pheasant chicks, possibly due to a higher susceptibility keywords: ac1; ac2; ac3; age; animals; birds; chicks; germany; inflammation; mycoplasma; pcr; pheasant; population; samples; virus cache: cord-333413-8buawes0.txt plain text: cord-333413-8buawes0.txt item: #553 of 672 id: cord-333522-zsdymkjd author: Gruse, Jeannine title: Quercetin Feeding in Newborn Dairy Calves Cannot Compensate Colostrum Deprivation: Study on Metabolic, Antioxidative and Inflammatory Traits date: 2016-01-11 words: 7029 flesch: 41 summary: Although quercetin is known to exert antioxidative effects, we did not find improved antioxidative status in the plasma of calves nor increased hepatic expression of antioxidative enzymes, which is in line with previous findings of our group in research conducted on neonatal calves and lactating dairy cows The aim of this work was to study effects of quercetin feeding on metabolic, antioxidative and inflammatory parameters in neonatal calves to investigate whether quercetin could compensate for insufficient colostrum supply. keywords: calves; colostrum; concentrations; day; days; effects; fed; feeding; fig; formula; groups; life; plasma; quercetin; status; table cache: cord-333522-zsdymkjd.txt plain text: cord-333522-zsdymkjd.txt item: #554 of 672 id: cord-333650-4towah1t author: Malmo, Jostein title: Cytokine Profiles in Human Metapneumovirus Infected Children: Identification of Genes Involved in the Antiviral Response and Pathogenesis date: 2016-05-12 words: 4668 flesch: 43 summary: Further, the expression of IL-6 ( Fig 4C) was not increased at mRNA level in any of the groups with hMPV infected children. The lack of IFN-γ detection in NPAs from hMPV infected children has also recently been reported elsewhere [31] . keywords: children; expression; hmpv; ifn; infection; mrna; patients; severity cache: cord-333650-4towah1t.txt plain text: cord-333650-4towah1t.txt item: #555 of 672 id: cord-333853-p2kbjwpy author: Smee, Donald F. title: Therapy and Long-Term Prophylaxis of Vaccinia Virus Respiratory Infections in Mice with an Adenovirus-Vectored Interferon Alpha (mDEF201) date: 2011-10-13 words: 4605 flesch: 45 summary: These results demonstrate the long-acting prophylactic and treatment capacity of mDEF201 to combat vaccinia virus infections. The results from these experiments indicate that mDEF201 has an extremely long-acting prophylactic activity against vaccinia virus infections in mice. keywords: day; days; infection; interferon; lung; mdef201; mice; vaccinia; virus cache: cord-333853-p2kbjwpy.txt plain text: cord-333853-p2kbjwpy.txt item: #556 of 672 id: cord-333955-bnzbppof author: Biesold, Susanne E. title: Type I Interferon Reaction to Viral Infection in Interferon-Competent, Immortalized Cell Lines from the African Fruit Bat Eidolon helvum date: 2011-11-30 words: 5030 flesch: 46 summary: However, there remains a fundamental lack of knowledge on the ways type I IFNs are induced and IFN signals are processed in bat cells. Here we present a set of essential tools to characterize IFN induction and -response in bat cells, and introduce a novel group of highly IFN-competent, immortalized bat cell lines from the species E. helvum that hosts relevant zoonotic viruses including Henipa-and Lyssaviruses keywords: bat; bats; cells; figure; helvum; ifn; induction; infection; lines; onnv; pcr; species; virus cache: cord-333955-bnzbppof.txt plain text: cord-333955-bnzbppof.txt item: #557 of 672 id: cord-334218-bkjfy66e author: Lin, Jung-Da title: Impact of Mated Female Nonproductive Days in Breeding Herd after Porcine Epidemic Diarrhea Virus Outbreak date: 2016-01-15 words: 3642 flesch: 51 summary: PEDV outbreak were compared using a two-way ANOVA for multiple comparisons. In addition to this pig farm, we also analyzed the productivity index during the 1-year period before and after PEDV outbreaks from one Taiwanese farrow-to-finish herd (500 sows). keywords: days; npds; outbreak; pedv; period; sows; weaning cache: cord-334218-bkjfy66e.txt plain text: cord-334218-bkjfy66e.txt item: #558 of 672 id: cord-334695-cjxlw1tu author: Kam, Yiu-Wing title: Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells In Vitro date: 2009-11-17 words: 6416 flesch: 38 summary: CONCLUSIONS/SIGNIFICANCE: These results suggest that SARS S-protein is susceptible to airway protease cleavage and, furthermore, that protease mediated enhancement of virus entry depends on specific conformation of SARS S-protein upon ACE2 binding. Altogether, we have identified at least two amino acid residues which are sensitive to airway protease cleavage in vitro and may be important for in vivo virus entry and fusion. keywords: airway; cells; cleavage; cov; covpp; entry; envelope; figure; fusion; glycoprotein; proteases; sars; spike; virus cache: cord-334695-cjxlw1tu.txt plain text: cord-334695-cjxlw1tu.txt item: #559 of 672 id: cord-334955-gnu92up6 author: Sutton, Jeannette title: COVID-19: Retransmission of official communications in an emerging pandemic date: 2020-09-16 words: 7803 flesch: 40 summary: We develop a lexicon of keywords associated with risk communication about the pandemic response, then use automated coding to identify message content and message structural features. First, to assess whether message content and structure varied between the two time periods of interest (before and after the national emergency declaration), we used chi-square tests to examine the association for message content and message structural features and whether the message was published before and after March 13, 2020. keywords: communication; content; declaration; emergency; features; health; information; message; message retransmission; public; retransmission; threat cache: cord-334955-gnu92up6.txt plain text: cord-334955-gnu92up6.txt item: #560 of 672 id: cord-335245-1eksm537 author: Pattyn, Els title: HyperISGylation of Old World Monkey ISG15 in Human Cells date: 2008-06-18 words: 7051 flesch: 48 summary: Mechanism and role in protein-ubiquitin conjugation UBE1L2, a novel E1 enzyme specific for ubiquitin Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/ beta-induced ubiquitin-like protein Interferoninducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins Screen for ISG15-crossreactive deubiquitinases UBP43 (USP18) specifically removes ISG15 from conjugated proteins UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection Mx genes show weaker primary response to virus than other interferon-regulated genes Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15 ISG15-dependent Regulation Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin Evidence for higher rates of nucleotide substitution in rodents than in man Proteomic identification of proteins conjugated to ISG15 in mouse and human cells Identification and Herc5-mediated ISGylation of novel target proteins Differential roles for arginine in the interaction with ubiquitin-activating enzyme Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease Autonomous regulation of the anaphasepromoting complex couples mitosis to S-phase entry UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme Sequential E2s drive polyubiquitin chain assembly on APC targets UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation Fanconi anemia and ubiquitination Chromatographic isolation of methionine-containing peptides for gel-free proteome analysis: identification of more than 800 Escherichia coli proteins A complex interaction pattern of CIS and SOCS2 with the leptin receptor Improved recovery of proteome-informative, protein N-terminal peptides by combined fractional diagonal chromatography (COFRADIC) keywords: activating; agmisg15; anti; cells; conjugation; enzyme; figure; huisg15; human; ifn; isg15; isgylation; protein; residue; ube1l; ubiquitin cache: cord-335245-1eksm537.txt plain text: cord-335245-1eksm537.txt item: #561 of 672 id: cord-335272-jypxi99z author: Sharma, Anupam Joya title: A cross-sectional study of psychological wellbeing of Indian adults during the Covid-19 lockdown: Different strokes for different folks date: 2020-09-03 words: 9805 flesch: 49 summary: Moreover, both qualitative and quantitative study findings suggested that greater frequency of calling family members during lockdown could strengthen social relationships and increase social empathy. Therefore, we posit that persons belonging to the LGBT community could suffer from increased stress during lockdown. keywords: adults; anxiety; covid-19; family; findings; lgbt; lockdown; participants; qualitative; risk; study; symptoms; time cache: cord-335272-jypxi99z.txt plain text: cord-335272-jypxi99z.txt item: #562 of 672 id: cord-335404-s48psqth author: Mukandavire, Zindoga title: Quantifying early COVID-19 outbreak transmission in South Africa and exploring vaccine efficacy scenarios date: 2020-07-24 words: 3578 flesch: 40 summary: Cumulative data for COVID-19 cases reported in South Africa from the 5 th March to 11 th April 2020 is shown in S1 Table. Following a similar approach in [37] , we use a Markov Chain Monte Carlo (MCMC) within a Bayesian framework (in R FME package [38] ) to fit the model to the cumulative data of confirmed COVID-19 cases in South Africa and estimate the magnitude of the epidemic using the basic reproductive number and quantify required vaccines' attributes to stem similar outbreaks. keywords: africa; covid-19; disease; epidemic; lockdown; model; south; vaccine cache: cord-335404-s48psqth.txt plain text: cord-335404-s48psqth.txt item: #563 of 672 id: cord-335441-bj3me7p8 author: Jourdain, Elsa title: Influenza Virus in a Natural Host, the Mallard: Experimental Infection Data date: 2010-01-28 words: 6383 flesch: 48 summary: A virus A/Turkey/Minn/BF/72 (Hv6Neq2) Highly pathogenic avian influenza virus infection of Mallards with homo-and heterosubtypic immunity induced by low-pathogenic avian influenza viruses Effects of influenza A virus infection on migrating mallard ducks Electrocardiography, heart rates, and heart weights of free-living birds Characteristics of the febrile response in Pekin ducks Ecologic immunology of avian influenza (H5N1) in migratory birds Ecological immunology: life-history trade-offs and immune defense in birds Effect of intravenous inoculation of avian influenza virus on reproduction and growth in mallard ducks Hampered foraging and migratory performance in swans infected with lowpathogenic avian influenza A virus Practical considerations for high-throughput influenza A virus surveillance studies of wild birds by use of molecular diagnostic tests Sampling for low-pathogenic avian influenza A virus in wild Mallard ducks: oropharyngeal versus cloacal swabbing Coinfection of wild ducks by influenza A viruses: distribution patterns and biological significance Immunology of avian influenza virus: a review Bile immunoglobulin of the duck (Anas platyrhynchos). Likewise, local immunity may influence the outcome of duck infections and provide protection against further infections. keywords: birds; body; day; days; ducks; h7n7; infection; influenza; inoculation; mallards; study; temperature; viral; virus cache: cord-335441-bj3me7p8.txt plain text: cord-335441-bj3me7p8.txt item: #564 of 672 id: cord-335505-s013j5ex author: Zhang, Chen title: Viral Etiology and Clinical Profiles of Children with Severe Acute Respiratory Infections in China date: 2013-08-22 words: 3187 flesch: 39 summary: Respiratory Viral Panel Fast in a clinical laboratory setting Comparison of three multiplex PCR assays for the detection of respiratory viral infections: evaluation of xTAG respiratory virus panel fast assay, RespiFinder 19 assay and RespiFinder SMART 22 assay Etiology and Incidence of viral and bacterial acute respiratory illness among older children and adults in rural western Kenya Molecular monitoring of causative viruses in child acute respiratory infection in endemo-epidemic situations in Shanghai Respiratory viruses in hospitalized children with acute lower respiratory tract infections in harbin, China Viral etiology of bronchiolitis among pediatric inpatients in northern Taiwan with emphasis on newly identified respiratory viruses Viral etiology of severe pneumonia among Kenyan infants and children Impact of parainfluenza virus infection in pediatric cancer patients Parainfluenza 3 virus and other common respiratory pathogens in children with human immunodeficiency virus infection Parainfluenza and influenza virus infections in pediatric organ transplant recipients Parainfluenza virus infection in adult lung transplant recipients: an emergent clinical syndrome with implications on allograft function Comparison of results of detection of rhinovirus by PCR and viral culture in human nasal wash specimens from subjects with and without clinical symptoms of respiratory illness Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children Secondary, Comparison analysis was firstly performed between urban and suburban/rural patients in china; In addition, this is also the first study on association analysis Estimates of mortality in children younger than 5 years for Burkina Faso A molecular epidemiological study of respiratory viruses detected in Japanese children with acute wheezing illness Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology Clinical and epidemiological comparison of human metapneumovirus and respiratory syncytial virus in seoul Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: a retrospective study of 27 years The global problem of antibiotic resistance A preliminary study of pneumonia etiology among hospitalized children in Kenya Etiology and epidemiology of viral pneumonia among hospitalized children in rural Mozambique: a malaria endemic area with high prevalence of human immunodeficiency virus The burden of respiratory syncytial virus infection in young children Human metapneumovirus and severity of respiratory syncytial virus disease Detection of human metapneumovirus in infants with acute respiratory tract infection Detection of respiratory viruses by molecular methods Development of a respiratory virus panel test for detection of twenty human respiratory viruses by use of multiplex PCR and a fluid microbead-based assay Comparison of the BD Directigen Flu A+B Kit and the Abbott TestPack RSV with a multiplex RT-PCR ELISA for rapid detection of influenza viruses and respiratory syncytial virus Comparison of the Luminex Respiratory Virus Panel fast assay with in-house real-time PCR for respiratory viral infection diagnosis Evaluation of multiple test methods for the detection of the novel 2009 influenza A (H1N1) during the New York City outbreak Enhanced viral etiological diagnosis of respiratory system infection outbreaks by use of a multitarget nucleic acid amplification assay Performance of a rapid molecular multiplex assay for the detection of influenza and picornaviruses Comparison of the Luminex xTAG keywords: children; etiology; infection; patients; sari; study; virus; viruses cache: cord-335505-s013j5ex.txt plain text: cord-335505-s013j5ex.txt item: #565 of 672 id: cord-335859-k37jivp6 author: Wu, Daphne C. title: Predictors of self-reported symptoms and testing for COVID-19 in Canada using a nationally representative survey date: 2020-10-21 words: 3113 flesch: 47 summary: The strongest predictor of testing was having COVID symptoms among members of the household, of whom about 16.5% were tested, compared to 2.1% among those without COVID symptoms among household members (OR = 6.63, 4.46- A nationally representative survey of Canadians finds that about 8% of adults report that they or someone in their household reported symptoms suggestive of COVID in March 2020. Here, we report on the results of the first nationally-representative poll in Canada of selfreported COVID symptoms conducted by the Angus Reid Forum in early April 2020 covering symptoms reported mostly in March 2020, prior to the peak month of test-reported cases in April. keywords: covid; household; sars; survey; symptoms; testing cache: cord-335859-k37jivp6.txt plain text: cord-335859-k37jivp6.txt item: #566 of 672 id: cord-335880-m8gecsf0 author: Peci, Adriana title: Epidemiology of Enterovirus D68 in Ontario date: 2015-11-23 words: 4034 flesch: 48 summary: Enterovirus D68 in the United States Detection and whole genome sequence analysis of an enterovirus 68 cluster Enterovirus 68 is associated with respiratory illness and shares biological features with both the enteroviruses and the rhinoviruses MMWR.Clusters of Acute Respiratory Illness Associated with Human Enterovirus 68-Asia, Europe, and United States Genetic Diversity of Human Enterovirus 68 Strains Isolated in Kenya Using the Hypervariable 3'-End of VP1 Gene Acute flaccid paralysis in a child infected with enterovirus D68: Laboratory testing identified enterovirus D68 (EV-D68) in respiratory specimens from most of these children. keywords: cases; d68; enterovirus; ontario; patients; specimens; testing cache: cord-335880-m8gecsf0.txt plain text: cord-335880-m8gecsf0.txt item: #567 of 672 id: cord-336364-2ust3qoq author: Artigas, Laura title: In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine storm date: 2020-10-02 words: 5863 flesch: 41 summary: Starting from different drug targets the effect of the drugs converges on human proteins with a known role in SARS-CoV-2 infection cycle. The 'Coronavirus-host interaction set' is composed of human proteins with a relevant role in SARS-CoV-2 infection and a set of human coronaviruses host interactome retrieved through manual curation of scientific publications (S1 Table) . keywords: ard; combination; cov-2; drug; effect; infection; melatonin; network; pirfenidone; proteins; sars; set cache: cord-336364-2ust3qoq.txt plain text: cord-336364-2ust3qoq.txt item: #568 of 672 id: cord-336420-1a2u9p4t author: Söderman, Martina title: Frequent Respiratory Viral Infections in Children with Febrile Neutropenia - A Prospective Follow-Up Study date: 2016-06-16 words: 4204 flesch: 41 summary: Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america A prospective study on the epidemiology of febrile episodes during chemotherapy-induced neutropenia in children with cancer or after hemopoietic stem cell transplantation Respiratory viruses, a common microbiological finding in neutropenic children with fever Frequency and Clinical Outcome of Respiratory Viral Infections and Mixed Viral-bacterial Infections in Children With Cancer, Fever and Neutropenia Nasopharyngeal Detection of Respiratory Viruses in Febrile Neutropenic Children Health-related quality of life anticipated with different management strategies for paediatric febrile neutropaenia European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the era of growing resistance: summary of the Antibiotic resistance is associated with longer bacteremic episodes and worse outcome in febrile neutropenic children with cancer Invasive fungal infections in paediatric acute myeloid leukaemia The Clinical Feature of Invasive Fungal Infection in Pediatric Patients With Hematologic and Malignant Diseases Community-acquired pneumonia requiring hospitalization among U.S. children Respiratory viral infections in children with leukemia Clinical utility of PCR for common viruses in acute respiratory illness Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values Upper respiratory virus detection without parent-reported illness in children is virus-specific Respiratory pathogens in children with and without respiratory symptoms Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children Frequent and prolonged shedding of bocavirus in young children attending daycare Development and implementation of a molecular diagnostic platform for daily rapid detection of 15 respiratory viruses Coexistence of two clades of enterovirus D68 in pediatric Swedish patients in the summer and fall of 2014 Screening respiratory samples for detection of human rhinoviruses (HRVs) and enteroviruses: comprehensive VP4-VP2 typing reveals high incidence and genetic diversity of HRV species C New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0 Management of respiratory viral infections in hematopoietic cell transplant recipients and patients with hematologic malignancies Influenza A/H1N1 in pediatric oncology patients Pathogenesis of bloodstream infection in children with blood cancer A prospective study of septicaemia on a paediatric oncology unit: a three-year experience at The Royal Liverpool Children's Hospital, Alder Hey, UK Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection Human rhinovirus species associated with hospitalizations for acute respiratory illness in young US children Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia High prevalence of human rhinovirus C infection in Thai children with acute lower respiratory tract disease Human rhinovirus C infections in pediatric hematology and oncology patients Respiratory syncytial viral infection in children with compromised immune function Epidemiology of multiple respiratory viruses in childcare attendees Duration of rhinovirus shedding in the upper respiratory tract in the first year of life Clinical assessment and improved diagnosis of bocavirus-induced wheezing in children Human bocavirus in children with acute lymphoblastic leukemia Persistence of human bocavirus DNA in immunocompromised children Although respiratory viruses are commonly associated with this condition, the etiologic significance of this finding remains unclear and is therefore the subject of this study. keywords: children; episodes; neutropenia; respiratory; viruses cache: cord-336420-1a2u9p4t.txt plain text: cord-336420-1a2u9p4t.txt item: #569 of 672 id: cord-336441-m6pur6td author: Wang, Changjian title: Features and drivers for energy-related carbon emissions in mega city: The case of Guangzhou, China based on an extended LMDI model date: 2019-02-11 words: 5187 flesch: 34 summary: WRI (World Resources Institute), C40 Cities Climate Leadership Group, ICLEI (International Council for Local Environmental Initiatives) Global Protocol for Community-Scale Greenhouse Gas Emission Inventories: An Accounting and Reporting Standard for Cities Decem Changes of CO2 emissions embodied in China-Japan trade: drivers and implications Consumption-based accounting of CO2 emissions Outsourcing CO2 within China City-level climate change mitigation in China Assessing the urban carbon footprint: An overview Greenhouse Gas Emissions from Chinese Cities A study on carbon emissions in Shanghai Energy and greenhouse gas emissions review for Macao The benchmarks of carbon emissions and policy implications for China's cities: Case of Nanjing Contributing to local policy making on GHG emission reduction through inventorying and attribution: A case study of Shenyang Carbon flow of urban system and its policy implications: The case of Nanjing Managing urban energy system: A case of Suzhou in China Embodied greenhouse gas emission by Macao Three-scale input-output modeling for urban economy: Carbon emission by Beijing Production and consumption accounting of CO2 emissions for Xiamen Using hybrid method to evaluate carbon footprint of Xiamen City Consumption-based emission accounting for Chinese cities An empirical research on the influencing factors of regional CO2 emissions: Evidence from Beijing city Features and influencing factors of carbon emissions indicators in the perspective of residential consumption: Evidence from Beijing Potential impacts of industrial structure on energy consumption and CO2 emission: a case study of Beijing Carbon dioxide emission drivers for a typical metropolis using input-output structural decomposition analysis Structural decomposition analysis of the carbonization process in Beijing: A regional explanation of rapid increasing carbon dioxide emission in China Delinking indicators on regional industry development and carbon emissions: Beijing-Tianjin-Hebei economic band case A local-scale low-carbon plan based on the STIR-PAT model and the scenario method: The case of Minhang District Estimation, characteristics, and determinants of energy-related industrial CO2 emissions in Decomposing the influencing factors of industrial carbon emissions in Shanghai using the LMDI method Using an extended LMDI model to explore technoeconomic drivers of energy-related industrial CO2 emission changes: A case study for Shanghai (China) A multi-sectoral decomposition analysis of city-level greenhouse gas emissions: Case study of Tianjin Using the STIRPAT model to explore the factors driving regional CO2 emissions: a case of Tianjin China's regional CO2 emissions reduction potential: A study of Chongqing city Mitigating greenhouse gas emissions from China's cities: Case study of Suzhou Decoupling analysis on energy consumption, embodied GHG emissions and economic growth-The case study of Macao Features, trajectories and driving forces for energyrelated GHG emissions from Chinese mega cites: The case of Beijing, Tianjin, Shanghai and Chongqing Consumption-based CO2 accounting of China's megacities: The case of Beijing The consumption-based black carbon emissions of China's megacities Comparing structural decomposition analysis and index Structural decomposition analysis applied to energy and emissions: Some methodological developments Influencing mechanism of energy-related carbon emissions in Xinjiang based on the input-output and structural decomposition analysis Influencing mechanism of energy-related carbon emissions in Xinjiang based on the input-output and structural decomposition analysis Carbon emissions decomposition and environmental mitigation policy recommendations for sustainable development in Shandong province Decomposition of energy-related carbon emissions in Xinjiang and relative mitigation policy recommendations The process of energy-related carbon emissions and influencing mechanism research in Xinjiang A new energy decomposition method: perfect in decomposition and consistent in aggregation Decomposition analysis for policymaking in energy: which is the preferred method? Earth's Future New provincial CO2 emission inventories in China based on apparent energy consumption data and updated emission factors Methodology and applications of city level CO2 emission accounts in China A synthesis of carbon dioxide emissions from fossil-fuel combustion Reduced carbon emission estimates from fossil fuel combustion and cement production in China Examining the driving factors of energy related carbon emissions using the extended STIRPAT model based on IPAT identity in Xinjiang Global and regional drivers of accelerating CO2 emissions 82. keywords: carbon; carbon emissions; china; city; consumption; effect; emissions; energy; guangzhou; intensity; urban cache: cord-336441-m6pur6td.txt plain text: cord-336441-m6pur6td.txt item: #570 of 672 id: cord-336615-jfnj6l41 author: Wong, Sarah Sze Wah title: In Vitro and In Vivo Activity of a Novel Antifungal Small Molecule against Candida Infections date: 2014-01-22 words: 7906 flesch: 49 summary: Moreover, Candida cell counts from tongue swabs of the SM21-treated mice (4.5610 2 CFUs/ml) were consistently lower than those of the control mice (4.8610 3 CFUs/ml) and the nystatin-treated animals (6.0610 2 CFUs/ml). Oral surgery, oral medicine, oral pathology Biofilm lifestyle of Candida: a mini review Epidemiology of Candida species infections in critically ill non-immunosuppressed patients Candida species bloodstream infection: epidemiology and outcome in a single institution from 1991 to Epidemiology of invasive candidiasis: a persistent public health problem Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options Candida bloodstream infections: comparison of species distributions and antifungal resistance patterns in community-onset and nosocomial isolates in the SENTRY Antimicrobial Surveillance Program Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance An insight into the antifungal pipeline: selected new molecules and beyond Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation Management of invasive fungal infections: a role for polyenes Persistent Candida albicans colonization and molecular mechanisms of azole resistance in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients Antimicrobial resistance: resistance to antifungal agents: mechanisms and clinical impact Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance At what cost echinocandin resistance Antifungal susceptibility and virulence attributes of bloodstream isolates of Candida from Hong Kong and Finland Emergence of a Candida krusei isolate with reduced susceptibility to caspofungin during therapy Antibacterial and antifungal drug discovery Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics Small-molecule inhibitors of the budded-to-hyphal-form transition in the pathogenic yeast Candida albicans An amino acid liquid synthetic medium for the development of mycelial and yeast forms of Candida albicans Reference method for broth dilution antifungal susceptibility testing of yeasts Biofilmforming ability of Candida albicans is unlikely to contribute to high levels of oral yeast carriage in cases of human immunodeficiency virus infection Improvement of XTT assay performance for studies involving Candida albicans biofilms Adhesion of oral Candida albicans isolates to denture acrylic following limited exposure to antifungal agents Antifungal resistance of candidal biofilms formed on denture acrylic in vitro Biofilm formation of Candida albicans is variably affected by saliva and dietary sugars keywords: 37uc; albicans; antifungal; assay; biofilm; candida; candidiasis; cells; figure; mice; sm21 cache: cord-336615-jfnj6l41.txt plain text: cord-336615-jfnj6l41.txt item: #571 of 672 id: cord-336843-c0sr3six author: Gerritsen, M. G. title: Improving early diagnosis of pulmonary infections in patients with febrile neutropenia using low-dose chest computed tomography date: 2017-02-24 words: 4327 flesch: 44 summary: Management of febrile neutropenia: ESMO Clinical Practice Guidelines A prospective survey of febrile events in hematological malignancies The utility of routine chest radiography in the initial evaluation of adult patients with febrile neutropenia patients undergoing HSCT Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america. Two previous studies have compared the use of CXR with LDCT in febrile neutropenic patients. keywords: cxr; detection; fever; ifd; ldct; neutropenia; patients; study cache: cord-336843-c0sr3six.txt plain text: cord-336843-c0sr3six.txt item: #572 of 672 id: cord-337067-j8ebslif author: Mades, Andreas title: Role of Human Sec63 in Modulating the Steady-State Levels of Multi-Spanning Membrane Proteins date: 2012-11-15 words: 8753 flesch: 43 summary: This prompted us to examine whether or not Sec63 may play a more general role in the production of ER proteins. It also did not affect the glycosylation pattern of VSV.G. Since these data are in seemingly conflict with the results obtained for the HBV envelope proteins, we next assessed the behavior of multispanning membrane proteins synthesized in the presence of upregulated Sec63. keywords: bip; cells; complex; control; dna; envelope; fig; function; hbv.s; human; levels; membrane; protein; sec63; signal; state; translocation; translocon cache: cord-337067-j8ebslif.txt plain text: cord-337067-j8ebslif.txt item: #573 of 672 id: cord-337585-kpghvb6u author: Moustaqim-Barrette, Amina title: Accessing Take-Home Naloxone in British Columbia and the role of community pharmacies: Results from the analysis of administrative data date: 2020-09-11 words: 4017 flesch: 44 summary: Relatedly, the higher proportion of pharmacy naloxone kit distribution in the Vancouver Coastal Region in the 2018 analytic sample is likely due to low reporting in high volume, low-capacity community sites in the Vancouver region compared to other regions. While analyses from the BCCDC shows that the BC THN program, combined with other harm reduction interventions, has averted thousands of opioid overdose deaths [20, 21] , there is still relatively little data in the published literature examining community reach and barriers to access of naloxone distribution programs in Canada. keywords: distribution; kits; naloxone; overdose; program; sites; thn cache: cord-337585-kpghvb6u.txt plain text: cord-337585-kpghvb6u.txt item: #574 of 672 id: cord-337630-ojhk5opy author: Tasic, Velibor title: Clinical and Functional Characterization of URAT1 Variants date: 2011-12-16 words: 5361 flesch: 40 summary: This data highlights the importance of renal urate transporters in determining serum urate concentrations, and the clinical phenotypes that should lead the renal clinician to suspect an inherited form of renal hypouricaemia. This data highlights the importance of renal urate transporters in determining serum urate concentrations and the of clinical phenotypes that should lead the clinician to suspect an inherited form of renal hypouricaemia. keywords: acid; analysis; exercise; heterozygous; hypouricaemia; mutations; patients; renal; serum; slc22a12; transporter; urate cache: cord-337630-ojhk5opy.txt plain text: cord-337630-ojhk5opy.txt item: #575 of 672 id: cord-337795-khqx4t4q author: Pellecchia, Umberto title: Social Consequences of Ebola Containment Measures in Liberia date: 2015-12-09 words: 5121 flesch: 47 summary: A body of literature exists on how public health measures negatively impact people without offering a substantial reduction of virus transmission An anthropological perspective allowed an understanding of socio-political implications of public health measures, analysing how these are practically experienced and performed by people keywords: cremation; ebola; epidemic; health; liberia; measures; monrovia; practices; quarantine; research; social cache: cord-337795-khqx4t4q.txt plain text: cord-337795-khqx4t4q.txt item: #576 of 672 id: cord-337879-liqhbqxl author: Kriesel, John D. title: Deep Sequencing for the Detection of Virus-Like Sequences in the Brains of Patients with Multiple Sclerosis: Detection of GBV-C in Human Brain date: 2012-03-08 words: 5064 flesch: 49 summary: A new arenavirus in a cluster of fatal transplant-associated diseases The complete genome of klassevirus -a novel picornavirus in pediatric stool Human enterovirus 109: a novel interspecies recombinant enterovirus isolated from a case of acute pediatric respiratory illness in Nicaragua Hepatitis G virus Identification of GBV-D, a novel GB-like flavivirus from old world frugivorous bats (Pteropus giganteus) in Bangladesh The natural history of nonhuman GB Virus C (GBV-Ccpz) in captive chimpanzees Review of the epidemiology, molecular characterization and tropism of the hepatitis G virus/GBV-C Evidence that the GBV-C/hepatitis G virus is primarily a lymphotropic virus Lack of GB virus C/hepatitis G virus sequences in cerebrospinal fluid in patients with central nervous system infections GB virus type C/Hepatitis G virus GBV-C/hepatitis G virus infection and non-Hodgkin lymphoma: a case control study The prevalence of hepatitis C and hepatitis G virus infection in patients with B cell non-Hodgkin lymphomas in Greece: a Hellenic Cooperative Oncology Group Study High prevalence of hepatitis G virus infection in Hodgkin's disease and Bcell lymphoproliferative disorders: absence of correlation with hepatitis C virus infection GB Virus Type C Envelope Protein E2 Elicits Antibodies That React with a Cellular Antigen on HIV-1 Particles and Neutralize Diverse HIV-1 Isolates Cluster analysis and display of genome-wide expression patterns Java Treeview-extensible visualization of microarray data Effect of primer selection on estimates of GB virus C (GBV-C) prevalence and response to antiretroviral therapy for optimal testing for GBV-C viremia Development of GBV-C E2 Monoclonal Antibodies that Precipitate HIV-1 Particles and Neutralize Diverse HIV-1 Isolates. [14] The GB viruses are approximately 10 kb in size and are most closely related to hepatitis C virus. keywords: brain; control; gbv; hepatitis; human; reads; rna; sequences; specimens; virus cache: cord-337879-liqhbqxl.txt plain text: cord-337879-liqhbqxl.txt item: #577 of 672 id: cord-337913-eu2gn4bl author: Stojanov, Ana title: Does Perceived Lack of Control Lead to Conspiracy Theory Beliefs? Findings from an online MTurk sample date: 2020-08-17 words: 7937 flesch: 41 summary: We consider the reasons why conspiracy theory beliefs do not appear to be based in any straightforward way on control beliefs, interrogating existing findings and presenting new data that call the relationship into question. Findings from an online MTurk sample date: 2020-08-17 journal: PLoS One DOI: 10.1371/journal.pone.0237771 sha: doc_id: 337913 cord_uid: eu2gn4bl It is widely believed that conspiracy theory beliefs are the product of perceived lack of control. keywords: beliefs; conspiracy; conspiracy theories; control; effect; group; participants; studies; study; theories; theory cache: cord-337913-eu2gn4bl.txt plain text: cord-337913-eu2gn4bl.txt item: #578 of 672 id: cord-338067-vjyad10p author: Hao, Yan title: Prediction and analysis of Corona Virus Disease 2019 date: 2020-10-05 words: 4784 flesch: 55 summary: A SVM with fuzzy granulation was used to predict the growth range of confirmed new cases, new deaths, and new cured cases. The SVM with fuzzy granulation can successfully predict the growth range of confirmed new cases and new cured cases, although the average predicted values are slightly large. keywords: cases; data; deaths; growth; layer; network; neural; prediction cache: cord-338067-vjyad10p.txt plain text: cord-338067-vjyad10p.txt item: #579 of 672 id: cord-338594-wft7yy6j author: Winkler, Michael title: Rhesus macaque IFITM3 gene polymorphisms and SIV infection date: 2017-03-03 words: 4642 flesch: 37 summary: key: cord-338594-wft7yy6j authors: Winkler, Michael; Gärtner, Sabine; Wrensch, Florian; Krawczak, Michael; Sauermann, Ulrike; Pöhlmann, Stefan title: Rhesus macaque IFITM3 gene polymorphisms and SIV infection date: 2017-03-03 journal: PLoS One DOI: 10.1371/journal.pone.0172847 sha: doc_id: 338594 cord_uid: wft7yy6j Interferon-induced transmembrane proteins (IFITMs) have been recognized as important antiviral effectors of the innate immune system, both in cell culture and in infected humans. This is noteworthy since IFITM3 polymorphisms in SIV-infection the N-terminal residues of IFITM3 control intracellular localization and spectrum of antiviral activity [32, 43, 44] and were suggested to be shaped by selective pressure during primate evolution [32] . keywords: animals; association; cohort; gene; human; infection; polymorphisms; proteins; rhesus; rhifitm3; siv; virus cache: cord-338594-wft7yy6j.txt plain text: cord-338594-wft7yy6j.txt item: #580 of 672 id: cord-339026-eu11larc author: Ryals, Renee C. title: The effects of PEGylation on LNP based mRNA delivery to the eye date: 2020-10-29 words: 4822 flesch: 41 summary: At 24 hours post-injection, 0.5% PEG particles with corresponding cholesterol modifications demonstrated significant 1.9-fold, 5.2-fold and 18.9-fold increases in luciferase activity compared to 1.5%, 3% and 5% PEG particles, respectively (Fig 2B, p<0 .05). At 24 hours post-injection, 0.5% PEG particles modulated against cholesterol demonstrated significant 2.7-fold, 3.0-fold and 17.5-fold increases in luciferase activity compared to 1.5%, 3% and 5% PEG particles, respectively (Fig 5B, p<0.05 ). keywords: delivery; expression; fold; lnp; lnps; particles; peg; post; rpe; size cache: cord-339026-eu11larc.txt plain text: cord-339026-eu11larc.txt item: #581 of 672 id: cord-339157-wj47xeqj author: Zhang, Chao title: Involvement of the renin-angiotensin system in the progression of severe hand-foot-and-mouth disease date: 2018-05-23 words: 3081 flesch: 50 summary: Previous studies have indicated that serum Ang II levels in patients with H7N9 infection were related to the severity of infection. Previous studies have indicated that serum Ang II levels in patients withH7N9 infection were higher than controls and were related to the severity of infection keywords: ang; cases; concentrations; dpi; ev71; hfmd cache: cord-339157-wj47xeqj.txt plain text: cord-339157-wj47xeqj.txt item: #582 of 672 id: cord-339327-4422s317 author: Norris, Susan L. title: An evaluation of emergency guidelines issued by the World Health Organization in response to four infectious disease outbreaks date: 2018-05-30 words: 3692 flesch: 41 summary: key: cord-339327-4422s317 authors: Norris, Susan L.; Sawin, Veronica Ivey; Ferri, Mauricio; Raques Sastre, Laura; Porgo, Teegwendé V. title: An evaluation of emergency guidelines issued by the World Health Organization in response to four infectious disease outbreaks date: 2018-05-30 journal: PLoS One DOI: 10.1371/journal.pone.0198125 sha: doc_id: 339327 cord_uid: 4422s317 BACKGROUND: The production of high-quality guidelines in response to public health emergencies poses challenges for the World Health Organization (WHO). We analyzed the development and publication processes and evaluated the quality of emergency guidelines using AGREE-II. keywords: development; emergency; guidelines; health; information; products; quality cache: cord-339327-4422s317.txt plain text: cord-339327-4422s317.txt item: #583 of 672 id: cord-339392-2ocz784l author: Sharma, Kulbhushan title: Influenza A Virus Nucleoprotein Exploits Hsp40 to Inhibit PKR Activation date: 2011-06-15 words: 6224 flesch: 46 summary: Likewise, Hsp40 is also known to regulate PKR signaling in influenza virus infected cells [25] . Apart from that, PKR activity is controlled by another mechanism where P58 IPK , the cellular inhibitor of PKR is activated in influenza virus infected cells [25, 28] . keywords: cells; fig; hsp40; iav; infection; influenza; inhibition; p58; phosphorylation; pkr; protein; virus cache: cord-339392-2ocz784l.txt plain text: cord-339392-2ocz784l.txt item: #584 of 672 id: cord-339578-eg19rfvi author: Garcia-Garcia, Maria Luz title: Role of viral coinfections in asthma development date: 2017-12-05 words: 3664 flesch: 40 summary: It can be hypothesized that this stronger TSLP response after viral coinfection bronchiolitis, could stimulate a vigorous production of Th2-associated effector cytokines, such as IL-4, IL-5, IL-13, as was reported in asthmatic adults by Ying et al, that could be associated with higher frequency of wheezing and asthma development later on [31] . In conclusion, asthma at the age of 6-8 is more frequent and severe in those children previously hospitalized with viral coinfection bronchiolitis compared with those with single infection. keywords: age; asthma; bronchiolitis; children; coinfections; wheezing; years cache: cord-339578-eg19rfvi.txt plain text: cord-339578-eg19rfvi.txt item: #585 of 672 id: cord-339724-roj8ksvc author: Lan, Jiaming title: Tailoring Subunit Vaccine Immunity with Adjuvant Combinations and Delivery Routes Using the Middle East Respiratory Coronavirus (MERS-CoV) Receptor-Binding Domain as an Antigen date: 2014-11-18 words: 5043 flesch: 45 summary: On the other hand, Th2 antibody responses can be induced by the Alum, as indicated by increased IgG1 relative to IgG2a The induction of a robust humoral, including potent neutralizing antibodies, and cellular immune response is likely essential for immediate and sustained protective immunity in a MERS-CoV vaccine design. keywords: adjuvant; antibody; cov; i+c; mers; mice; protein; rbd; regimes; response; vaccination; vaccine cache: cord-339724-roj8ksvc.txt plain text: cord-339724-roj8ksvc.txt item: #586 of 672 id: cord-339789-151d1j4n author: Hong, Hyokyoung G. title: Estimation of time-varying reproduction numbers underlying epidemiological processes: A new statistical tool for the COVID-19 pandemic date: 2020-07-21 words: 3939 flesch: 53 summary: bðtÞg À 1 ðtÞ < 1 leads to that i(t + 1) < i(t) or the number of infectious cases drops, meaning the spread of virus is controlled; otherwise, the number of infectious cases will keep increasing. We note that (9) is directly based on true numbers of infectious cases and removed cases derived from the discrete SIR model (6) . keywords: cases; countries; covid-19; data; model; number; time cache: cord-339789-151d1j4n.txt plain text: cord-339789-151d1j4n.txt item: #587 of 672 id: cord-339796-gccnvh0z author: Zhang, Si Min title: Membrane-Active Sequences within gp41 Membrane Proximal External Region (MPER) Modulate MPER-Containing Peptidyl Fusion Inhibitor Activity and the Biosynthesis of HIV-1 Structural Proteins date: 2015-07-31 words: 9101 flesch: 40 summary: Dimerization of anti-viral peptides has been shown to enhance both their structural stability and the number of interaction sites and thus their anti-viral efficacy Precipitated pseudotyped HIV-1 viral particles dissolved in RIPA buffer were also prepared in Laemmli reducing buffer. keywords: anti; cells; entry; env; fig; fusion; gag; gp41; membrane; mper; p24; peptides; protein; residues; sequence; terminal; trp; virus cache: cord-339796-gccnvh0z.txt plain text: cord-339796-gccnvh0z.txt item: #588 of 672 id: cord-339869-euikj8fv author: Cebey-López, Miriam title: Does Viral Co-Infection Influence the Severity of Acute Respiratory Infection in Children? date: 2016-04-20 words: 3327 flesch: 35 summary: Current opinion in pharmacology Comparison of multiplex PCR assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness Clinical utility of PCR for common viruses in acute respiratory illness Viral Co-Infections in Pediatric Patients Hospitalized with Lower Tract Acute Respiratory Infections Clinical disease severity of respiratory viral co-infection versus single viral infection: a systematic review and meta-analysis Respiratory pathogens in children with and without respiratory symptoms Frequent detection of viral coinfection in children hospitalized with acute respiratory tract infection using a real-time polymerase chain reaction The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis Viral etiology of acute febrile respiratory illnesses in hospitalized children younger than 24 months Diagnostic value of respiratory virus detection in symptomatic children using real-time PCR Infection with multiple viruses is not associated with increased disease severity in children with bronchiolitis. Pediatric pulmonology Single versus dual respiratory virus infections in hospitalized infants: impact on clinical course of disease and interferon-gamma response Respiratory syncytial virus, its coinfection and paediatric lower respiratory infections. keywords: children; cohort; disease; infection; severity; study; viruses cache: cord-339869-euikj8fv.txt plain text: cord-339869-euikj8fv.txt item: #589 of 672 id: cord-339920-dr5bvpm0 author: Soberman, Roy J. title: CD200R1 Supports HSV-1 Viral Replication and Licenses Pro-Inflammatory Signaling Functions of TLR2 date: 2012-10-17 words: 7486 flesch: 45 summary: Because morbidity and mortality to HSV-1 infection is secondary to increased brain inflammation (as well as lytic virus replication), we predicted that CD200R1 2/2 mice would have a marked increase in both brain inflammation and mortality when compared to CD200R1 +/+ mice. On day 1, CD200R1 2/2 brains had significantly lower levels of IFN-b than CD200R1 +/+ mice ( Figure 4D ). keywords: cd200r1; cells; expression; hsv-1; infection; levels; macrophages; mice; replication; response; signaling; tlr2; virus cache: cord-339920-dr5bvpm0.txt plain text: cord-339920-dr5bvpm0.txt item: #590 of 672 id: cord-340027-6l55rcfm author: Mamode Khan, Naushad title: Studying the trend of the novel coronavirus series in Mauritius and its implications date: 2020-07-10 words: 3629 flesch: 43 summary: This paper proposes an integer-valued time series model to analyze the series of COVID-19 cases in Mauritius wherein the corresponding innovation term accommodates for covariate specification. Based on the proposed COM-Poisson mixture models, we could predict the number of COVID-19 cases in Mauritius. keywords: cases; covid-19; health; mauritius; model; number; y t cache: cord-340027-6l55rcfm.txt plain text: cord-340027-6l55rcfm.txt item: #591 of 672 id: cord-340195-425rd7ul author: Smith, Kristine M. title: Zoonotic Viruses Associated with Illegally Imported Wildlife Products date: 2012-01-10 words: 4434 flesch: 44 summary: The scale of illegal meat importation from Africa to Europe via Paris The problems and promise of DNA barcodes for species diagnosis of primate biomaterials Identification of mosquito blood meals using mitochondrial cytochrome oxidase subunit I and cytochrome b gene sequences Ancient co-speciation of simian foamy viruses and primates Universal primer cocktails for fish DNA barcoding DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates Naturally acquired simian retrovirus infections in Central African hunters Molecular detection of anthrax spores on animal fibres Detection and analysis of diverse herpesviral species by consensus primer PCR Rapid molecular strategy for filovirus detection and characterization Sensitive and broadly reactive reverse transcription-PCR assays to detect novel paramyxoviruses Identification of a severe acute respiratory syndrome coronavirus-like virus in a leaf-nosed bat in Nigeria Identification of a Kunjin/West Nile-like flavivirus in brains of patients with New York encephalitis Detection of orthopoxvirus DNA by realtime PCR and identification of variola virus DNA by melting analysis All simian DNA samples from USFWS were also screened for larger SFV pol sequences (465-bp) as done at the CDC but were found in only one baboon sample (CII-163). keywords: bushmeat; health; nhp; products; samples; sequences; sfv; species; specimens; study; united; virus; wildlife cache: cord-340195-425rd7ul.txt plain text: cord-340195-425rd7ul.txt item: #592 of 672 id: cord-340387-ohkjheat author: Wynne, James W. title: Purification and Characterisation of Immunoglobulins from the Australian Black Flying Fox (Pteropus alecto) Using Anti-Fab Affinity Chromatography Reveals the Low Abundance of IgA date: 2013-01-07 words: 7022 flesch: 47 summary: Antiserum generated against P. alecto IgG H showed reactivity to IgG H of the fruit bats P. conspicillatus and, to a lesser extent, Rosettus megaphylus (Fig. 7B, lanes 2 and 3 respectively) . P. alecto bats were captured in southern Queensland, Australia as described previously [35] and transported live by air to the CSIRO Australian Animal Health Laboratory (AAHL). keywords: affinity; alecto; bats; fab; fig; human; iga; igg; igm; immunoglobulin; mucosal; p. alecto; protein; sds; serum cache: cord-340387-ohkjheat.txt plain text: cord-340387-ohkjheat.txt item: #593 of 672 id: cord-340627-xyvzgkxl author: Ornaghi, Sara title: Performance of an extended triage questionnaire to detect suspected cases of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in obstetric patients: Experience from two large teaching hospitals in Lombardy, Northern Italy date: 2020-09-15 words: 3810 flesch: 46 summary: Admission questionnaires may have limitations since they rely on honest answering. However, our detailed investigation of minor SARS-CoV-2 triage questionnaire in obstetric patients symptoms, such as loss of smell or taste, may also have played an important role [3, 29] . keywords: admission; cov-2; infection; patients; questionnaire; sars; women cache: cord-340627-xyvzgkxl.txt plain text: cord-340627-xyvzgkxl.txt item: #594 of 672 id: cord-340656-ltd6ueoi author: Grant, Michael C. title: The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries date: 2020-06-23 words: 3443 flesch: 38 summary: Analysis of clinical symptoms in adult patients Clinical and Laboratory Profiles of 75 Hospitalized Patients with Novel Coronavirus Disease Clinical features and outcomes of 197 adult discharged patients with COIVD-19 in Yichang Optimizing diagnostic strategy for novel coronavirus pneumonia The necessity to address deficiencies in current literature and potential to substantially improve the precision of estimates of symptom prevalence using both indexed and (the more voluminous and up-to-date) preprint literature from multiple geographical regions, represents the rational for this review. keywords: characteristics; clinical; coronavirus; covid-19; patients; prevalence; studies; symptoms cache: cord-340656-ltd6ueoi.txt plain text: cord-340656-ltd6ueoi.txt item: #595 of 672 id: cord-340703-vtuy806l author: Cascio, Antonio title: Low bone mineral density in HIV-positive young Italians and migrants date: 2020-09-03 words: 4494 flesch: 51 summary: In examining the gender in mono-infected HIV patients, the percentages of HIV patients were significantly greater in Italian males in comparison to migrant males (57.6% > 25%, p = 0.007). Our data confirm that early screening for low BMD and other risk factors associated with bone loss in HIV patients is useful keywords: bmd; bone; hiv; itg; low; migrants; osteoporosis; patients; study cache: cord-340703-vtuy806l.txt plain text: cord-340703-vtuy806l.txt item: #596 of 672 id: cord-340713-v5sdowb7 author: Bird, Jordan J. title: Country-level pandemic risk and preparedness classification based on COVID-19 data: A machine learning approach date: 2020-10-28 words: 5672 flesch: 49 summary: With the previous successful experiments in mind, this argues that risk classification would be more useful when performed prior to the situation unfolding, given that country-level information is seemingly more important at this stage when compared to the current postpeak climate. The positive effects of these factors likely contribute towards the reason why country-level information was useful for risk classification earlier in the pandemic, but are less-so later on post-peak. keywords: attributes; classification; country; covid-19; data; learning; level; machine; models; risk; test cache: cord-340713-v5sdowb7.txt plain text: cord-340713-v5sdowb7.txt item: #597 of 672 id: cord-340718-amfs4zay author: Zhu, Gengping title: Potential Geographic Distribution of the Novel Avian-Origin Influenza A (H7N9) Virus date: 2014-04-01 words: 2396 flesch: 36 summary: We developed two datasets based on seasonal variation in Normalized Difference Vegetation Index (NDVI) from the MODIS sensor to characterize environmental dimensions of H7N9 virus. We used a maximum entropy algorithm (Maxent; [14] ) to estimate an ecological 'niche' for H7N9 virus. keywords: areas; cases; china; h7n9; model; virus cache: cord-340718-amfs4zay.txt plain text: cord-340718-amfs4zay.txt item: #598 of 672 id: cord-340763-cxnu9g8y author: Grimm, Sebastian K. title: Directed Evolution of a Yeast-Displayed HIV-1 SOSIP gp140 Spike Protein toward Improved Expression and Affinity for Conformational Antibodies date: 2015-02-17 words: 7847 flesch: 37 summary: [50] [51] , suggesting that the display of HIV envelope protein is feasible in principle. Therefore, and because of the well-established and characterized Aga1/2-based display system, S. cerevisiae was chosen as host for HIV spike protein display. keywords: antibodies; antibody; binding; cells; display; envelope; fig; gp120; hiv; human; min; mutations; protein; sosip; variants; yeast cache: cord-340763-cxnu9g8y.txt plain text: cord-340763-cxnu9g8y.txt item: #599 of 672 id: cord-340766-aic570x8 author: Kim, Se Jin title: Outcomes of Early Administration of Cidofovir in Non-Immunocompromised Patients with Severe Adenovirus Pneumonia date: 2015-04-15 words: 3634 flesch: 37 summary: We described the clinical characteristics and treatment outcomes of early cidofovir treatment of severe AdV pneumonia in non-immunocompromised patients. In the present study, we described favorable outcomes to antiviral therapy with cidofovir in non-immunocompromised adult patients with severe AdV pneumonia. keywords: adenovirus; adv; cidofovir; days; patients; pneumonia; study cache: cord-340766-aic570x8.txt plain text: cord-340766-aic570x8.txt item: #600 of 672 id: cord-340937-6mpob1nx author: Varshney, Mohit title: Initial psychological impact of COVID-19 and its correlates in Indian Community: An online (FEEL-COVID) survey date: 2020-05-29 words: 3665 flesch: 46 summary: The survey collected data on socio-demographic and clinical variables related to COVID-19 (based on the current knowledge); along with measuring psychological impact with the help of Impact of Event–revised (IES-R) scale. The survey collected data on socio-demographic and clinical variables related to COVID-19 (based on the current knowledge); along with measuring psychological impact with the help of Impact of Eventrevised (IES-R) scale. keywords: coronavirus; covid-19; health; impact; outbreak; respondents; study; survey cache: cord-340937-6mpob1nx.txt plain text: cord-340937-6mpob1nx.txt item: #601 of 672 id: cord-341097-c96hm610 author: Mayer, Craig S. title: Analysis of data dictionary formats of HIV clinical trials date: 2020-10-05 words: 6901 flesch: 54 summary: To demonstrate some examples of study data elements, Table 1 shows the element data dictionary from study NCT00099359: 'Trial of Three Neonatal Antiretroviral Regimens for Prevention of Intrapartum HIV Transmission.' We also describe relevant standards for study data dictionaries. keywords: clinical; common; data; dictionaries; dictionary; elements; format; hiv; sharing; studies; study; values cache: cord-341097-c96hm610.txt plain text: cord-341097-c96hm610.txt item: #602 of 672 id: cord-341880-wxliz485 author: Mottaleb, Khondoker Abdul title: COVID-19 induced economic loss and ensuring food security for vulnerable groups: Policy implications from Bangladesh date: 2020-10-16 words: 7554 flesch: 57 summary: By multiplying the estimated per head average daily wage earnings (in BDT) in the farm sector W f and that in the nonfarm sector W nf by the absolute number of daily waged workers in those in Bangladesh, the expected loss of daily wage earnings due to the COVID-19 induced lockdown is calculated as follows: To estimate the minimum compensation package for the daily wage-based workers to ensure the minimum food security, we specify and estimate a function that explains household level daily food expenditure for the household of daily wage worker i (that is, survey respondent i) in sector s, as follows: where lnEDFX is the natural log of the household level daily total expenditure on all food (in terms of BDT); wage earnings, lnDWEH is is the natural log of the total daily wage earning of the household of respondent i calculated as: The definitions of the vectors of variables ILC is and RLC is are the same as explained in Eq (1). It provides the share of total wage earnings are spent on household level daily food expenditure of a sampled day-labor household in farm and nonfarm sectors. keywords: bangladesh; covid-19; expenditure; farm; food; household; level; lockdown; nonfarm; table; total; wage; workers cache: cord-341880-wxliz485.txt plain text: cord-341880-wxliz485.txt item: #603 of 672 id: cord-341914-l2bomgji author: Flies, Andrew S. title: Markedly Elevated Antibody Responses in Wild versus Captive Spotted Hyenas Show that Environmental and Ecological Factors Are Important Modulators of Immunity date: 2015-10-07 words: 6632 flesch: 39 summary: Wild hyenas are regularly observed feeding on carcasses from which lions, jackals, and vultures, have also fed, and wild hyenas often engage in fierce battles with other carnivores. Our results show that wild hyenas have significantly higher serum antibody concentrations, including total IgG and IgM, natural antibodies, and autoantibodies than do captive hyenas; there was no difference in the bacterial killing capacity of sera collected from captive and wild hyenas. keywords: anti; antibodies; concentrations; defenses; exposure; hyenas; igg; igm; immune; klh; levels; pathogen; serum; total; wild cache: cord-341914-l2bomgji.txt plain text: cord-341914-l2bomgji.txt item: #604 of 672 id: cord-342133-khrljehj author: Principi, Nicola title: Bocavirus Infection in Otherwise Healthy Children with Respiratory Disease date: 2015-08-12 words: 5125 flesch: 44 summary: respiratory viral panel fast for diagnosis of respiratory virus infections MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods Datamonkey: a suite of phylogenetic analysis tools for evolutionary biology Not so different after all: a comparison of methods for detecting amino acid sites under selection Adaptation to different human populations by HIV-1 revealed by codon-based analyses Detecting individual sites subject to episodic diversifying selection Seroepidemiology of human bocavirus in Hokkaido prefecture Seroepidemiology of human bocavirus infection in Jamaica Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children Human bocavirus in children: mono-detection, high viral load and viraemia are associated with respiratory tract infection Human bocavirus detection in nasopharyngeal aspirates of children without clinical symptoms of respiratory infection Human bocavirus infections in hospitalized children and adults Detection of bocavirus in saliva of children with and without respiratory illness Human bocavirus 1 primary infection and shedding in infants Single detection of human bocavirus 1 with a high viral load in severe respiratory tract infections in previously healthy children Human bocavirus detection in an atopic child affected by pneumonia associated with wheezing Detection of human bocavirus in hospitalised children Human bocavirus in children suffering from acute lower respiratory tract infection in Beijing Children's Hospital Clinical characteristics of human bocavirus infections compared with other respiratory viruses in Spanish children Role of human metapneumovirus, human coronavirus NL63 and human bocavirus in infants and young children with acute wheezing Role of emerging respiratory viruses in children with severe acute wheezing Etiology of bronchiolitis in a hospitalized pediatric population: prospective multicenter study Absence of humanbocavirus in bronchoalveolar lavage fluid of lung transplant patients Neurological manifestations in acute onset of viral gastroenteritis Frequency and clinical relevance of human bocavirus infection in acute exacerbations of chronic obstructive pulmonary disease Human bocavirus in children: mono-detection, high viral load and viraemia are associated with respiratory tract infection Human bocavirus in patients with respiratory tract infection Comorbidity and high viral load linked to clinical presentation of respiratory human bocavirus infection Frequent and prolonged shedding of bocavirus in young children attending daycare Correlation between nucleotide mutation and viral loads of human bocavirus 1 in hospitalized children with respiratory tract infection Phospholipase A2-like activity of human bocavirus VP1 unique region Human bocavirus amongst an allages population hospitalised with acute lower respiratory infections in Cambodia Complete coding sequences and phylogenetic analysis of Human Bocavirus (HBoV) Human bocavirus capsid structure: insights into the structural repertoire of the parvoviridae Evolutionary relationships among parvoviruses: virus-host coevolution among autonomous primate parvoviruses and links between adeno-associated and avian parvoviruses Epidemic and molecular evolution of human bocavirus in hospitalized children with acute respiratory tract infection Rapid molecular evolution of human bocavirus revealed by Bayesian coalescent inference The study patients were classified into disease groups (i.e., acute otitis media, rhinosinusitis, pharyngitis, croup, infectious wheezing, acute bronchitis, pneumonia) on the basis of signs and/or symptoms using well-established criteria and were finally subdivided into two subgroups: upper (URTIs) and lower respiratory tract infections (LRTIs) keywords: acid; amino; bocavirus; children; disease; hbov; infection; load; samples; strains; study; tract cache: cord-342133-khrljehj.txt plain text: cord-342133-khrljehj.txt item: #605 of 672 id: cord-342476-0rupk21u author: van Rijn, Anneloes L. title: The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease date: 2019-10-24 words: 4038 flesch: 39 summary: Correlation between qPCR Cq value and logarithm of normalized numbers of mNGS viral reads was tested with population Pearson correlation coefficient. No correlation was found between viral reads and clinical markers. keywords: copd; exacerbations; mngs; pathogens; patients; pcr; reads; samples; study; virome; viruses cache: cord-342476-0rupk21u.txt plain text: cord-342476-0rupk21u.txt item: #606 of 672 id: cord-342519-tjr6dvtt author: Souza, Thiago Moreno L. title: H1N1pdm Influenza Infection in Hospitalized Cancer Patients: Clinical Evolution and Viral Analysis date: 2010-11-30 words: 5170 flesch: 42 summary: Because the analysis of this novel viral infection in cancer patients is an important component of the 2009 pandemics, we conducted a prospective cohort study aimed at evaluating the clinical course of influenza infection, the duration of viral shedding, H1N1pdm evolution and the emergence of antiviral resistance in hospitalized cancer patients with a severe H1N1pdm infection in a reference cancer center during the winter of 2009 in Brazil. Prolonged influenza A H1N1pdm shedding was observed in cancer patients. keywords: cancer; days; h1n1pdm; infection; influenza; oseltamivir; pandemic; patients; shedding; table; virus cache: cord-342519-tjr6dvtt.txt plain text: cord-342519-tjr6dvtt.txt item: #607 of 672 id: cord-342639-vf9n2vf9 author: Chang, Chung-ke title: Transient Oligomerization of the SARS-CoV N Protein – Implication for Virus Ribonucleoprotein Packaging date: 2013-05-23 words: 5393 flesch: 36 summary: The data is consistent with the helical oligomer packing model of N protein observed in crystal. These results qualitatively suggest that the CTD of SARS-CoV N protein is capable of transient self-association through the oligomer interface identified in the crystal structure. keywords: coronavirus; cov; ctd; disulfide; n protein; nucleocapsid; oligomerization; protein; rna; sars; structure cache: cord-342639-vf9n2vf9.txt plain text: cord-342639-vf9n2vf9.txt item: #608 of 672 id: cord-342730-b7y8mybg author: Dellagi, Koussay title: Pandemic Influenza Due to pH1N1/2009 Virus: Estimation of Infection Burden in Reunion Island through a Prospective Serosurvey, Austral Winter 2009 date: 2011-09-29 words: 5978 flesch: 42 summary: However, seasonal influenza vaccines were of rather limited use in Reunion Island, especially in children and young adults; iv) Finally the high baseline titers may reflect the infectious history of the individuals to seasonal influenza viruses cross antigenic with pH1N1/2009 virus as recently suggested for seasonal 2007 H1N1 infection Lower infection rates were found in adults and the lowest rates were recorded in the elderly. keywords: age; antibody; epidemic; h1n1; hia; infection; influenza; pandemic; rates; seroconversion; virus cache: cord-342730-b7y8mybg.txt plain text: cord-342730-b7y8mybg.txt item: #609 of 672 id: cord-343135-m0pdixw5 author: Marguet, Christophe title: In Very Young Infants Severity of Acute Bronchiolitis Depends On Carried Viruses date: 2009-02-25 words: 3346 flesch: 44 summary: Bronchiolitis-associated hospitalizations among US children Comparison of multiplex PCR assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness Association of rhinovirus infection with increased disease severity in acute bronchiolitis Human metapneumovirus as a causative agent of acute bronchiolitis in infants The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis Rhinovirus-associated wheezing in infancy: comparison with respiratory syncytial virus bronchiolitis Respiratory syncytial virus infection Prospective multicenter study of bronchiolitis: predicting safe discharges from the emergency department Clinical impact and diagnosis of human metapneumovirus infection Impact of human metapneumovirus and respiratory syncytial virus co-infection in severe bronchiolitis Preliminary evaluation of a multiplex reverse transcription-PCR assay combined with a new DNA chip hybridization assay for detecting respiratory syncytial virus Single virus versus dual respiratory virus infections in hospitalized infants. A birth cohort study Human metapneumovirus infections cause similar symptoms and clinical severity as respiratory syncytial virus infections Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis Role of metapneumovirus in viral respiratory infections in young children Severity of respiratory syncytial virus bronchiolitis is affected by cigarette smoke exposure and atopy Respiratory syncytial virus infections in hospitalized infants: association between viral load, virus subgroup, and disease severity IL-10 gene polymorphism at -1082 A/G is associated with severe rhinovirus bronchiolitis in infants Are responses to treatment virus-specific in wheezing children? keywords: bronchiolitis; infants; rsv; severity; virus cache: cord-343135-m0pdixw5.txt plain text: cord-343135-m0pdixw5.txt item: #610 of 672 id: cord-343973-n5ogyxz7 author: Ip, Andrew title: Hydroxychloroquine and tocilizumab therapy in COVID-19 patients—An observational study date: 2020-08-13 words: 4336 flesch: 40 summary: key: cord-343973-n5ogyxz7 authors: Ip, Andrew; Berry, Donald A.; Hansen, Eric; Goy, Andre H.; Pecora, Andrew L.; Sinclaire, Brittany A.; Bednarz, Urszula; Marafelias, Michael; Berry, Scott M.; Berry, Nicholas S.; Mathura, Shivam; Sawczuk, Ihor S.; Biran, Noa; Go, Ronaldo C.; Sperber, Steven; Piwoz, Julia A.; Balani, Bindu; Cicogna, Cristina; Sebti, Rani; Zuckerman, Jerry; Rose, Keith M.; Tank, Lisa; Jacobs, Laurie G.; Korcak, Jason; Timmapuri, Sarah L.; Underwood, Joseph P.; Sugalski, Gregory; Barsky, Carol; Varga, Daniel W.; Asif, Arif; Landolfi, Joseph C.; Goldberg, Stuart L. title: Hydroxychloroquine and tocilizumab therapy in COVID-19 patients—An observational study date: 2020-08-13 journal: PLoS One DOI: 10.1371/journal.pone.0237693 sha: doc_id: 343973 cord_uid: n5ogyxz7 Hydroxychloroquine has been touted as a potential COVID-19 treatment. This retrospective observational cohort study of 2512 hospitalized COVID-19 patients within a 13-hospital network did not find the empirical use of hydroxychloroquine with or without co-treatment with azithromycin to be associated with a reduction in mortality (adjusted HR, 0.99 for any hydroxychloroquine during hospitalization keywords: azithromycin; covid-19; drug; hospital; hydroxychloroquine; observational; patients; study; tocilizumab; treatment cache: cord-343973-n5ogyxz7.txt plain text: cord-343973-n5ogyxz7.txt item: #611 of 672 id: cord-344152-pb1e2w7s author: Kolatkar, Anand title: C-ME: A 3D Community-Based, Real-Time Collaboration Tool for Scientific Research and Training date: 2008-02-20 words: 5460 flesch: 42 summary: These annotations provide additional information about the atomic structure or image data that can then be evaluated, amended or added to by other project members. Now, the reader can step through the C-ME annotations extracted from the paper and watch as the relevant portions of the structure are highlighted to place additional data, such as activity assays, sequence comparisons, and protein purification gels, in the context of the structural features. keywords: annotations; application; data; entity; image; information; molecular; project; research; system; time; user cache: cord-344152-pb1e2w7s.txt plain text: cord-344152-pb1e2w7s.txt item: #612 of 672 id: cord-344357-ocyaqs1y author: Fu, Yue-Qiang title: Effect of blood analysis and immune function on the prognosis of patients with COVID-19 date: 2020-10-30 words: 4485 flesch: 54 summary: Another study also indicated that COVID-19 patients in the death group had significantly lower lymphocyte count on admission than the recovered group [8] . In the present study, the ROC analysis determined that admission leukocyte count, neutrophil percentage, neutrophil count, lymphocyte percentage, and lymphocyte count were able to predict the mortality of COVID-19 patients. keywords: cd4; count; covid-19; group; lymphocyte; neutrophil; patients cache: cord-344357-ocyaqs1y.txt plain text: cord-344357-ocyaqs1y.txt item: #613 of 672 id: cord-344782-ond1ziu5 author: Zhang, Jing title: Identification of a novel nidovirus as a potential cause of large scale mortalities in the endangered Bellinger River snapping turtle (Myuchelys georgesi) date: 2018-10-24 words: 6005 flesch: 45 summary: Similarity to other viruses for each of the ORFs and their predicted amino acid sequences were determined by searches using BLASTn and BLASTp [13] algorithms through the NCBI server (http://blast.ncbi.nlm.nih.gov/Blast.cgi). Ball Python Nidovirus: a Candidate Etiologic Agent for Severe Respiratory Disease in Python regius Identification of a novel nidovirus in an outbreak of fatal respiratory disease in ball pythons (Python regius) Novel divergent nidovirus in a python with pneumonia Nidovirus-Associated Proliferative Pneumonia in the Green Tree Python (Morelia viridis) Discovery and partial genomic characterisation of a novel nidovirus associated with respiratory disease in wild shingleback lizards (Tiliqua rugosa) Redefining the invertebrate RNA virosphere The evolutionary history of vertebrate RNA viruses Programmed translational frameshifting Ribosomal frameshifting on viral RNAs The primary structure and expression of the second open reading frame of the polymerase gene of the coronavirus MHV-A59 a highly conserved polymerase is expressed by an efficient ribosomal frameshifting mechanism An RNA Pseudoknot in the 3' end of the Arterivirus genome has a critical role in regulating viral RNA synthesis Changes to taxonomy and the international code of virus classification and Nomenclature ratified by the international committee on taxonomy of viruses Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates Molecular comparison of isolates of an emerging fish pathogen, Koi herpesvirus, and the effect of water temperature on mortality of experimentally infected Koi Is horizontal transmission of the ostreid herpesvirus OsHV-1 in Crassostrea gigas affected by unselected or selected survival status in adults to juveniles? keywords: acid; animals; disease; georgesi; min; nidovirus; pcr; python; river; rna; samples; sequence; species; tissues; turtle; virus cache: cord-344782-ond1ziu5.txt plain text: cord-344782-ond1ziu5.txt item: #614 of 672 id: cord-344839-r05p9h0e author: Majmundar, Monil title: Efficacy of corticosteroids in non-intensive care unit patients with COVID-19 pneumonia from the New York Metropolitan region date: 2020-09-09 words: 4077 flesch: 40 summary: Hä ussler U. Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids Steroid Conversion Calculator-MDCalc Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease Corticosteroid therapy for patients hospitalized with community-acquired pneumonia: The role of systemic corticosteroid as a therapeutic agent for patients with COVID-19 pneumonia is controversial. keywords: cohort; corticosteroid; covid-19; icu; intubation; patients; ratio; study cache: cord-344839-r05p9h0e.txt plain text: cord-344839-r05p9h0e.txt item: #615 of 672 id: cord-344870-tbgqulpu author: Lloyd-Smith, James O. title: Maximum Likelihood Estimation of the Negative Binomial Dispersion Parameter for Highly Overdispersed Data, with Applications to Infectious Diseases date: 2007-02-14 words: 5998 flesch: 46 summary: [16] and the present results for ML estimation: the positive bias of k mom was fairly constant as m increased (though the range of k mom values was greatest for lower m), while the bias of ML estimates k decreased for higher m (Fig. 1) . Estimation from outbreak datasets does not increase the bias of k estimates, but can add significant upward bias to estimates of the mean. keywords: datasets; distribution; estimates; values cache: cord-344870-tbgqulpu.txt plain text: cord-344870-tbgqulpu.txt item: #616 of 672 id: cord-345019-i7zm9bt1 author: Al-Waleedi, Ali Ahmed title: The first 2 months of the SARS-CoV-2 epidemic in Yemen: Analysis of the surveillance data date: 2020-10-29 words: 4500 flesch: 51 summary: These included demographic information, signs and symptoms, history of contact with other cases, history of travel, comorbidities, and hospitalization data. The median age among confirmed cases was 46 years (range: 1–90 years), and 75% of the confirmed cases were male. keywords: cases; country; cov-2; covid-19; data; epidemic; sars; yemen cache: cord-345019-i7zm9bt1.txt plain text: cord-345019-i7zm9bt1.txt item: #617 of 672 id: cord-345695-5vi9wibk author: Hicks, Lorin L. title: A statistical approach to white-nose syndrome surveillance monitoring using acoustic data date: 2020-10-22 words: 5499 flesch: 44 summary: We developed a simple and repeatable statistical modeling approach for WNS surveillance monitoring with bat activity data collected from a broad geographic and temporal scale prior to known occurrence of WNS in the Intermountain West. We investigated relationships among bat activity, ambient temperatures, and season prior to presence of WNS across forested sites of Montana, USA where WNS was not known to occur. keywords: activity; bat; bats; data; forest; model; monitoring; north; sites; species; temperature; winter; wns; year cache: cord-345695-5vi9wibk.txt plain text: cord-345695-5vi9wibk.txt item: #618 of 672 id: cord-345717-ktajrf7d author: Monagin, Corina title: Serologic and behavioral risk survey of workers with wildlife contact in China date: 2018-04-03 words: 4588 flesch: 42 summary: This study, examining the association between reported wildlife contact and seropositivity for wildlife zoonotic viruses, found detectable levels of antibodies for several pathogens in the population surveyed. We deliberately targeted high risk individuals, making our sample less representative of the general population. keywords: animal; china; contact; disease; human; individuals; risk; sars; seropositivity; study; wildlife cache: cord-345717-ktajrf7d.txt plain text: cord-345717-ktajrf7d.txt item: #619 of 672 id: cord-346067-zly8p0y7 author: Ruiz-Irastorza, Guillermo title: Second week methyl-prednisolone pulses improve prognosis in patients with severe coronavirus disease 2019 pneumonia: An observational comparative study using routine care data date: 2020-09-22 words: 4555 flesch: 48 summary: In the model with mortality as single outcome, week-2-MP patients showed lower mortality (HR 0.24, 95%CI 0.05 to 1.24, p = 0.088), whilst non-pulse glucocorticoid patients had an increased risk of death (HR 2.44, 95%CI 0.88 to 6.76, p = 0.087), both compared with patients with no glucocorticoids. Patients were divided into 4 groups: a) no-glucocorticoids, i.e. patients not receiving glucocorticoids in any form (n = 122); b) non-pulse glucocorticoids, i.e. patients receiving glucocorticoids at doses lower than 100 mg/d for periods longer than 3 days (n = 36, with 10 of them also receiving pulses); c) out-of-week-2-MP, i.e. MP at week 1 or 3, with no additional glucocorticoids at lower doses (n = 30); d) week-2-MP, i.e. patients receiving MP during week 2, with no additional glucocorticoids at lower doses (n = 54). keywords: covid-19; disease; glucocorticoids; patients; study; week-2 cache: cord-346067-zly8p0y7.txt plain text: cord-346067-zly8p0y7.txt item: #620 of 672 id: cord-346089-u31n0qxa author: McDade, Thomas W. title: High seroprevalence for SARS-CoV-2 among household members of essential workers detected using a dried blood spot assay date: 2020-08-14 words: 2235 flesch: 46 summary: Serological testing for SARS-CoV-2 IgG antibodies in DBS samples can facilitate seroprevalence assessment in community settings to address epidemiological questions, monitor duration of antibody responses, and assess if antibodies against the spike protein correlate with protection from reinfection. We adapted this ELISA to measure IgG antibodies to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein in DBS samples. keywords: antibodies; dbs; household; samples; sars; testing cache: cord-346089-u31n0qxa.txt plain text: cord-346089-u31n0qxa.txt item: #621 of 672 id: cord-346314-o9fjpqaj author: Jarboui, Mohamed Ali title: Nucleolar Protein Trafficking in Response to HIV-1 Tat: Rewiring the Nucleolus date: 2012-11-15 words: 10059 flesch: 29 summary: The proteasome regulates HIV-1 transcription by both proteolytic and nonproteolytic mechanisms Oncogenic activity of MCM7 transforming cluster Unzipped and loaded: the role of DNA helicases and RFC clamp-loading complexes in sister chromatid cohesion The XRCC genes: expanding roles in DNA double-strand break repair Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection Lupus autoantigen Ku protein binds HIV-1 TAR RNA in vitro Effect of Ku80 depletion on the preintegrative steps of HIV-1 replication in human cells Identification of cellular cofactors for human immunodeficiency virus replication via a ribozyme-based genomics approach siRNA screening of a targeted library of DNA repair factors in HIV infection reveals a role for base excision repair in HIV integration The dynamics of HMG proteinchromatin interactions in living cells Retroviral cDNA integration: stimulation by HMG I family proteins HIV-1 cDNA integration: requirement of HMG I(Y) protein for function of preintegration complexes in vitro Activity of the human immunodeficiency virus type 1 cell cycle-dependent internal ribosomal entry site is modulated by IRES trans-acting factors Fuel feeds function: energy metabolism and the T-cell response Human immunodeficiency virus type 1, human protein interaction database at NCBI Patterns of HIV-1 protein interaction identify perturbed host-cellular subsystems The biological context of HIV-1 host interactions reveals subtle insights into a system hijack HIVhost interactions: a map of viral perturbation of the host system Cataloguing the HIV type 1 human protein interaction network Retroviral proteomics and interactomes: intricate balances of cell survival and viral replication Dual role of host cell factors in HIV-1 replication: restriction and enhancement of the viral cycle Decoding the multifaceted HIV-1 virus-host interactome Functions of Tat: the versatile protein of human immunodeficiency virus type 1 Chromatin dynamics associated with HIV-1 Tat-activated transcription Modifications in host cell cytoskeleton structure and function mediated by intracellular HIV-1 Tat protein are greatly dependent on the second coding exon Pathway analysis in HEK 293T cells overexpressing HIV-1 tat and nucleocapsid Expression profiles and pathway analysis in HEK 293 T cells overexpressing HIV-1 Tat and nucleocapsid using cDNA microarray Proliferative activity of extracellular HIV-1 Tat protein in human epithelial cells: expression profile of pathogenetically relevant genes Proteomics analysis of human astrocytes expressing the HIV protein Tat HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages Gene expression profile of HIV-1 Tat expressing cells: a close interplay between proliferative and differentiation signals Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression Cell-type-specific proteome and interactome: using HIV-1 Tat as a test case Differentially expressed genes in HIV-1 tat-expressing CD4(+) T-cell line HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription Genome-wide binding map of the HIV-1 Tat protein to the human genome Jurkat T cells and development of the T-cell receptor signalling paradigm Global survey of human T leukemic cells by integrating proteomics and transcriptomics profiling A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity DEDD and DEDD2 associate with caspase-8/10 and signal cell death Chaperones and multitasking proteins in the nucleolus: networking together for survival? Protein B23 is an important human factor for the nucleolar localization of the human immunodeficiency virus protein Tat Spatial association of HIV-1 tat protein and the nucleolar transport protein B23 in stably transfected Jurkat T-cells Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element Effects of a highly basic region of human immunodeficiency virus Tat protein on nucleolar localization A region of basic amino-acid cluster in HIV-1 Tat protein is essential for trans-acting activity and nucleolar localization Intracellular trafficking and interactions of the HIV-1 Tat protein Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells The ins and outs of HIV-1 Tat Tuning the transport properties of HIV-1 Tat arginine-rich motif in living cells In vivo study of HIV-1 Tat arginine-rich motif unveils its transport properties Direct interaction of the human I-mfa domain-containing protein Tat results in cytoplasmic sequestration and control of Tat activity The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin betadependent nuclear localization signals The HIV-1 Tat nuclear localization sequence confers novel nuclear import properties Global enhancement of nuclear localization-dependent nuclear transport in transformed cells Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import Nuclear Factor 90, a cellular dsRNA binding protein inhibits the HIV Rev-export function Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors The ins and outs of HIV Rev The HIV-1 Rev protein The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function Mechanisms of receptor-mediated nuclear import and nuclear export The nuclear pore component Nup358 promotes transportin-dependent nuclear import A nucleolar TAR decoy inhibitor of HIV-1 replication Ribozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNA Constitutive expression of HIV-1 tat protein in human Jurkat T cells using a BK virus vector Gautier VW Proteomic profiling of the human T-cell nucleolus keywords: abundance; analysis; anti; cells; enrichment; expression; figure; fold; gene; human; jurkat; nuclear; nucleolar; nucleolus; pathway; proteins; replication; ribosomal; rna; tap; tat; tat expression; tat protein; virus cache: cord-346314-o9fjpqaj.txt plain text: cord-346314-o9fjpqaj.txt item: #622 of 672 id: cord-346347-r4ork18p author: Borrion, Hervé title: Measuring the resilience of criminogenic ecosystems to global disruption: A case-study of COVID-19 in China date: 2020-10-14 words: 7568 flesch: 44 summary: A set of indicators and mathematical models are introduced that aim to quantitatively describe changes in crime levels in comparison to what could otherwise be expected, and what might be expected by way of adaptation and subsequent resumption of those patterns. To overcome this violation of assumption we propose indicators that take account of the difference between crime levels under two scenarios: with and without the disrupting event (Eq 5): where, D(n) is the difference between Y F (n) and Y A (n), the forecasted crime (under normal conditions) and actual crime time-series (daily crime counts), and n is the (temporal) index of the time-series. keywords: case; covid-19; crime; indicators; metrics; patterns; performance; period; phase; point; public; resilience; time cache: cord-346347-r4ork18p.txt plain text: cord-346347-r4ork18p.txt item: #623 of 672 id: cord-346586-fxxceffl author: Razanajatovo, Norosoa Harline title: Epidemiology of severe acute respiratory infections from hospital-based surveillance in Madagascar, November 2010 to July 2013 date: 2018-11-21 words: 4153 flesch: 45 summary: The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: implications for management guidelines Transmission characteristics of the 2009 H1N1 influenza pandemic: comparison of 8 Southern hemisphere countries Severe acute respiratory infection in children in a densely populated urban slum in Kenya Etiology and Incidence of viral and bacterial acute respiratory illness among older children and adults in rural western Kenya Severe Acute Respiratory Illness Deaths in Sub-Saharan Africa and the Role of Influenza: A Case Series From 8 Excess mortality associated with the 2009 A(H1N1)v influenza pandemic in Antananarivo Outcome Risk Factors during Respiratory Infections in a Paediatric Ward in Antananarivo Viral etiology of influenza-like illnesses in Antananarivo Etiology of communityacquired pneumonia in 254 hospitalized children Respiratory viral coinfections identified by a 10-plex real-time reverse-transcription polymerase chain reaction assay in patients hospitalized with severe acute respiratory illness-South Africa Viral Co-Infections in Pediatric Patients Hospitalized with Lower Tract Acute Respiratory Infections Viral and atypical bacterial etiology of acute respiratory infections in children under 5 years old living in a rural tropical area of Madagascar Viral etiology of severe pneumonia among Kenyan infants and children Incidence of Medically Attended Respiratory Syncytial Virus and Influenza Illnesses in Children 6-59 Months Old During Four Seasons Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and metaanalysis Viral etiology of severe acute respiratory infections in hospitalized children in Cameroon Sentinel surveillance system for early outbreak detection in Madagascar Unfinished business: severe acute respiratory infection in sub-Saharan Africa The national burden of influenza-associated severe acute respiratory illness hospitalization in Rwanda key: cord-346586-fxxceffl authors: Razanajatovo, Norosoa Harline; Guillebaud, Julia; Harimanana, Aina; Rajatonirina, Soatiana; Ratsima, Elisoa Hariniaina; Andrianirina, Zo Zafitsara; Rakotoariniaina, Hervé; Andriatahina, Todisoa; Orelle, Arnaud; Ratovoson, Rila; Irinantenaina, Judickaelle; Rakotonanahary, Dina Arinalina; Ramparany, Lovasoa; Randrianirina, Frédérique; Richard, Vincent; Heraud, Jean-Michel title: Epidemiology of severe acute respiratory infections from hospital-based surveillance in Madagascar, November 2010 to July 2013 date: 2018-11-21 journal: PLoS One DOI: 10.1371/journal.pone.0205124 sha: doc_id: 346586 cord_uid: fxxceffl BACKGROUND: keywords: age; children; infections; influenza; patients; sari; years cache: cord-346586-fxxceffl.txt plain text: cord-346586-fxxceffl.txt item: #624 of 672 id: cord-346819-11fkgzaa author: Khan, Mohd Imran title: Comparative genome analysis of novel coronavirus (SARS-CoV-2) from different geographical locations and the effect of mutations on major target proteins: An in silico insight date: 2020-09-03 words: 4408 flesch: 48 summary: In this study, we have made an attempt to investigate the SARS-CoV-2 genome reported from 13 different countries, identification of mutations in major coronavirus proteins of these different SARS-CoV-2 genomes and compared with SARS-CoV. These thirteen complete genome sequences of SARS-CoV-2 showed high identity (>99%) to each other, while they shared 82% identity with SARS-CoV. Here, we performed a very systematic mutational analysis of SARS-CoV-2 genomes from different geographical locations, which enabled us to identify numerous unique features of this viral genome. The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2 Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL (pro)) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates Structure of M(pro) from COVID-19 virus and discovery of its inhibitors Structure of the RNA-dependent RNA polymerase from COVID-19 virus Structure of SARS coronavirus spike receptor-binding domain complexed with receptor Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Insight into the effect of inhibitor resistant S130G mutant on physico-chemical properties of SHV type beta-lactamase: a molecular dynamics study Comparative analysis of complete genome sequences of three avian coronaviruses reveals a novel group 3c coronavirus Identification of a novel coronavirus from a beluga whale by using a panviral microarray Coronavirus genomics and bioinformatics analysis COVID-2019: The role of the nsp2 and nsp3 in its pathogenesis The establishment of reference sequence for SARS-CoV-2 and variation analysis Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine The spike protein of SARS-CoV-a target for vaccine and therapeutic development Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus Can one predict protein stability? keywords: amino; analysis; coronavirus; cov; genome; mpro; mutation; protein; rna; sars; spike cache: cord-346819-11fkgzaa.txt plain text: cord-346819-11fkgzaa.txt item: #625 of 672 id: cord-346858-18q8rxzg author: Hossain, Md. Tanvir title: Social and electronic media exposure and generalized anxiety disorder among people during COVID-19 outbreak in Bangladesh: A preliminary observation date: 2020-09-11 words: 3464 flesch: 48 summary: Social Health and Behavior Mental health problems and social media exposure during COVID-19 outbreak Understanding the mental health effects of indirect exposure to mass trauma through the media Understanding depression from psycholinguistic patterns in social media texts2020 We aimed at assessing the prevalence of anxiety among Bangladeshi people during the pandemic in connection with social media exposure (SME) and electronic media exposure (EME). keywords: anxiety; covid-19; exposure; health; media; participants; sme cache: cord-346858-18q8rxzg.txt plain text: cord-346858-18q8rxzg.txt item: #626 of 672 id: cord-347014-88zmtky7 author: Esposito, Susanna title: Sensitivity and Specificity of Soluble Triggering Receptor Expressed on Myeloid Cells-1, Midregional Proatrial Natriuretic Peptide and Midregional Proadrenomedullin for Distinguishing Etiology and to Assess Severity in Community-Acquired Pneumonia date: 2016-11-15 words: 5520 flesch: 39 summary: When PCT was considered, the cut-off values with the highest combined sensitivity and specificity were ≥0.188 ng/mL for bacterial CAP and ≤0.07 ng/mL for viral CAP. Furthermore, the differentiation of viral from bacterial CAP is necessary for the rational use of antibiotics and the consequent reduction in the emergence of bacterial resistance and drug-related adverse events [3] . keywords: bacterial; cap; cases; children; crp; pct; pneumonia; proanp; results cache: cord-347014-88zmtky7.txt plain text: cord-347014-88zmtky7.txt item: #627 of 672 id: cord-347317-qcghtkk0 author: Russo, Lucia title: Tracing day-zero and forecasting the COVID-19 outbreak in Lombardy, Italy: A compartmental modelling and numerical optimization approach date: 2020-10-30 words: 9793 flesch: 44 summary: Our analysis further revealed that the actual number of asymptomatic infected cases in the total population in the period until March 8 was around 15 times the number of confirmed infected cases, which until March 8 was also approximately equal to the number of cases that were hospitalized and admitted to ICUs. The model approximated adequately two months ahead of time the evolution of reported cases of infected until May 4, the day on which the phase I of the relaxation of measures was implemented over all of Italy. keywords: cases; covid-19; day; lombardy; march; model; number; outbreak; period; population; reproduction number; time cache: cord-347317-qcghtkk0.txt plain text: cord-347317-qcghtkk0.txt item: #628 of 672 id: cord-347465-yu6oj30v author: Kurskaya, Olga title: Viral etiology of acute respiratory infections in hospitalized children in Novosibirsk City, Russia (2013 – 2017) date: 2018-09-18 words: 3385 flesch: 39 summary: Prevalence of respiratory viruses among children hospitalized from respiratory infections in Shenzhen, China Estimates of world-wide distribution of child deaths from acute respiratory infections Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life: a birth cohort study Multiplex real-time PCR for detection of respiratory tract infections Epidemiology of human respiratory viruses in children with acute respiratory tract infections in Jinan, China Respiratory virus infections in hospitalized children and adults in Lao PDR. [32] and it may be due to decreased sensitivity to respiratory virus infections in older children. keywords: age; aris; children; infections; influenza; respiratory; viruses cache: cord-347465-yu6oj30v.txt plain text: cord-347465-yu6oj30v.txt item: #629 of 672 id: cord-348055-azlb1zy1 author: Patel, Mira C. title: Enterovirus D-68 Infection, Prophylaxis, and Vaccination in a Novel Permissive Animal Model, the Cotton Rat (Sigmodon hispidus) date: 2016-11-04 words: 7780 flesch: 48 summary: Enterovirus surveillance-United States Molecular epidemiology of enterovirus D68 from 2013 to 2014 in Philippines Acute respiratory infections due to enterovirus 68 in Yamagata Enterovirus 68 among children with severe acute respiratory infection, the Philippines Molecular evolution of enterovirus 68 detected in the Philippines Enterovirus 68 in children with acute respiratory tract infections Lineages, sub-lineages and variants of enterovirus 68 in recent outbreaks Molecular epidemiology and evolution of human enterovirus serotype 68 in Thailand Detection of enterovirus 68 as one of the commonest types of enterovirus found in patients with acute respiratory tract infection in China Continued seasonal circulation of enterovirus D68 in the Netherlands Emergence and epidemic occurrence of enterovirus 68 respiratory infections in The Netherlands in 2010 Distinct cellular immune responses following primary and secondary influenza virus challenge in cotton rats Evidence of a cross-protective immune response to influenza A in the cotton rat model Induction of type I interferons and interferoninducible Mx genes during respiratory syncytial virus infection and reinfection in cotton rats Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease Enhanced pulmonary pathology in cotton rats upon challenge after immunization with inactivated parainfluenza virus 3 vaccines The TLR4 agonist, monophosphoryl lipid A, attenuates the cytokine storm associated with respiratory syncytial virus vaccine-enhanced disease Coxsackievirus A16 induced neurological disorders in young gerbils which could serve as a new animal model for vaccine evaluation The cotton rat: an underutilized animal model for human infectious diseases can now be exploited using specific reagents to cytokines, chemokines, and interferons Interferon-inducible Mx gene expression in cotton rats: cloning, characterization, and expression during influenza viral infection Rhinoviruses and Respiratory Enteroviruses: Not as Simple as ABC Unusual type of epidemic conjunctivitis in Ghana Pandemic of new type of conjunctivitis New enteroviruses, EV-93 and EV-94, associated with acute flaccid paralysis in the Democratic Republic of the Congo Enterovirus 94, a proposed new serotype in human enterovirus species D Detection and genetic characterization of enteroviruses circulating among wild populations of chimpanzees in Cameroon: relationship with human and simian enteroviruses Co-circulation of enteroviruses between apes and humans A probable new human picornavirus associated with respiratory diseases Phylogenetic characterization of enterovirus 68 strains in patients with respiratory syndromes in Italy Worldwide emergence of multiple clades of enterovirus 68 Global reemergence of enterovirus D68 as an important pathogen for acute respiratory infections Centers for Disease C, Prevention. keywords: animals; cotton; d68; fig; infection; lung; p.i; rats; strains; vanbt; virus cache: cord-348055-azlb1zy1.txt plain text: cord-348055-azlb1zy1.txt item: #630 of 672 id: cord-348243-e5tdb08v author: Schermer, Bernhard title: Rapid SARS-CoV-2 testing in primary material based on a novel multiplex RT-LAMP assay date: 2020-11-02 words: 3962 flesch: 48 summary: Next, the reaction was diluted with 80 μl of HybriDetect Buffer (Milenia), mixed, and then a HybriDetect dipstick (Milenia) was placed in the reaction tube and incubated at RT. Transferring such assays to automated microfluidic formats [11] can become an important tool to support disease control strategies. keywords: assays; cov-2; detection; lamp; reaction; rna; sars cache: cord-348243-e5tdb08v.txt plain text: cord-348243-e5tdb08v.txt item: #631 of 672 id: cord-348499-7ll7sd3o author: Manderstedt, Eric title: Genetic variation in the C-type lectin receptor CLEC4M in type 1 von Willebrand Disease patients date: 2018-02-01 words: 5452 flesch: 49 summary: The ABO gene showed the strongest effect, but smaller effects were seen for the STXBP5, SCARA5, VWF, STAB2, STX2, TC2N and CLEC4M genes. Supporting information S1 von Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy The genetic basis of von Willebrand disease Clearance of von Willebrand factor Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels Macrophage LRP1 contributes to the clearance of von Willebrand factor Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association Effect of genetic variation in STXBP5 and STX2 on von Willebrand factor and bleeding phenotype in type 1 von Willebrand disease patients The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels CLEC4M and STXBP5 gene variations contribute to von Willebrand factor level variation in von Willebrand disease The origin and evolution of variable number tandem repeat of CLEC4M gene in the global human population The VNTR polymorphism of the DC-SIGNR gene and susceptibility to HIV-1 infection: a meta-analysis Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection Determination of DC-SIGN and DC-SIGNR repeat region variations The heritage of pathogen pressures and ancient demography in the human innate-immunity keywords: clec4; gene; patients; population; type; variants; vntr; vwd; vwf cache: cord-348499-7ll7sd3o.txt plain text: cord-348499-7ll7sd3o.txt item: #632 of 672 id: cord-348807-9xxc5hyl author: Cuomo, Raphael E. title: Sub-national longitudinal and geospatial analysis of COVID-19 tweets date: 2020-10-28 words: 3241 flesch: 37 summary: Z-scores for trends from the resultant emerging hot spot analysis for COVID-19 cases per capita were compared to z-scores for trends from emerging hot spot analysis for COVID-19 tweets per capita. Confirmed COVID-19 cases, deaths, and recoveries were obtained from Johns Hopkins University Github CSSEGISandData/COVID-19 repository [2] . keywords: cases; covid-19; data; health; states; time; tweets; united cache: cord-348807-9xxc5hyl.txt plain text: cord-348807-9xxc5hyl.txt item: #633 of 672 id: cord-349029-zyfop43z author: Dobrovolny, Hana M. title: Modeling the role of asymptomatics in infection spread with application to SARS-CoV-2 date: 2020-08-10 words: 4601 flesch: 43 summary: It is also possible to accumulate large numbers of asymptomatic individuals if symptomatic infections are removed from the epidemic, either through death, recovery, or isolation, faster than asymptomatic infections. In this study, we use a compartmental mathematical model of a viral epidemic that includes asymptomatic infection to examine the role of asymptomatic individuals in the spread of the infection. keywords: asymptomatic; cov-2; epidemic; individuals; infections; sars cache: cord-349029-zyfop43z.txt plain text: cord-349029-zyfop43z.txt item: #634 of 672 id: cord-349217-vpih1wvs author: Petropoulos, Fotios title: Forecasting the novel coronavirus COVID-19 date: 2020-03-31 words: 3164 flesch: 55 summary: Answering this question requires accurate forecasting the spread of confirmed cases as well as analysis of the number of deaths and recoveries. We focus on the cumulative daily figures aggregated globally of the three main variables of interest: confirmed cases, deaths and recoveries. keywords: cases; coronavirus; data; forecasting; forecasts cache: cord-349217-vpih1wvs.txt plain text: cord-349217-vpih1wvs.txt item: #635 of 672 id: cord-349476-iac9fak3 author: Mao, Liang title: Evaluating the Combined Effectiveness of Influenza Control Strategies and Human Preventive Behavior date: 2011-10-17 words: 4666 flesch: 40 summary: Health agencies are recommended to gain prior knowledge about behavioral patterns of local people before choosing influenza control strategies. The preventive behavior of individuals could save medical resources for control strategies and avoid unnecessary socio-economic interruptions. keywords: behavior; control; effectiveness; epidemic; individuals; influenza; scenario; strategies cache: cord-349476-iac9fak3.txt plain text: cord-349476-iac9fak3.txt item: #636 of 672 id: cord-349781-l93978vq author: Cong, Yu title: MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cells date: 2018-03-22 words: 5673 flesch: 47 summary: To address pharmaceutical efficacy against MERS-CoV infection in primary cells critical for blocking infection, we tested several candidate MERS-antivirals in human MDMs and immature dendritic cells. These results demonstrate the value of testing drugs in primary cells, in addition to established cell lines, before initiating preclinical or clinical studies for MERS treatment and the importance of carefully assessing cytotoxicity in drug screen assays. keywords: apcs; cells; cov; cytokines; cytotoxicity; immature; infection; mddcs; mdms; mers; virus cache: cord-349781-l93978vq.txt plain text: cord-349781-l93978vq.txt item: #637 of 672 id: cord-349911-dx8wvqkm author: Dahl, Viktor title: Communicable Diseases Prioritized According to Their Public Health Relevance, Sweden, 2013 date: 2015-09-23 words: 4094 flesch: 47 summary: When we estimated FTEs for surveillance through notifications per pathogen we found that 95% of FTEs were spent on surveillance through notifications for pathogens in the highest and the high priority group. Discrepancies between ongoing surveillance through notifications and surveillance through typing and the outcome of the prioritization procedure should be interpreted with caution since there might be good reasons for not having surveillance for the pathogens in the highest priority group or for having surveillance for pathogens in the low priority group. keywords: group; health; pathogens; priority; surveillance; sweden cache: cord-349911-dx8wvqkm.txt plain text: cord-349911-dx8wvqkm.txt item: #638 of 672 id: cord-350398-w75flrwv author: Sampath, Rangarajan title: Comprehensive Biothreat Cluster Identification by PCR/Electrospray-Ionization Mass Spectrometry date: 2012-06-29 words: 11154 flesch: 47 summary: Assembly of this comprehensive collection of biothreat cluster primers into a single assay on the PLEX-ID has the potential to serve a variety of biosecurity needs. Coupling biothreat cluster-specific PCR to electrospray ionization mass spectrometry simultaneously provides the breadth of coverage, discrimination of near neighbors, and an extremely low false positive rate due to the requirement that an amplicon with a precise base composition of a biothreat agent be detected by mass spectrometry. Technology for detecting biothreat agents requires accurate identification of a broad array of bacterial and viral organisms that can cause severe disease and/or death, whether they occur as a result of a biological attack or from a natural source in the environment. keywords: agents; analysis; anthracis; assay; base; biothreat; clusters; data; detection; organisms; pairs; pcr; pestis; primer; primer pairs; samples; signatures; species; strains; table; tularensis cache: cord-350398-w75flrwv.txt plain text: cord-350398-w75flrwv.txt item: #639 of 672 id: cord-350443-ca5avyjf author: Zhang, Lei title: Trends in Notifiable Infectious Diseases in China: Implications for Surveillance and Population Health Policy date: 2012-02-16 words: 7966 flesch: 45 summary: In 1955, a total of 5,970,000 malaria cases were reported nationally, accounting for 68% of the total number of reported infectious disease cases and an incidence of 1,028 per 100,000 population. Vaccine-preventable diseases, bacterial infections and gastrointestinal diseases were the greatest causes of death, accounting for 30.0%, 24.0% and 19.5% of reported infectious diseases death cases among Chinese population in 1975 ( Figure 1b) . keywords: cases; china; chinese; diseases; epidemic; health; hiv; mortality; number; population; rate; surveillance; transmission cache: cord-350443-ca5avyjf.txt plain text: cord-350443-ca5avyjf.txt item: #640 of 672 id: cord-350842-4m82l5t8 author: Xing, Jun title: Study of the mental health status of medical personnel dealing with new coronavirus pneumonia date: 2020-05-19 words: 3223 flesch: 44 summary: In subsequent research in this project, a longitudinal study should be conducted that uses a wider sample and measures the mental health status of medical personnel from multiple dimensions, which can help better identify the mutual influence between demographic data and mental health status. key: cord-350842-4m82l5t8 authors: Xing, Jun; Sun, Ning; Xu, Jun; Geng, Shuling; Li, Yuqian title: Study of the mental health status of medical personnel dealing with new coronavirus pneumonia date: 2020-05-19 journal: PLoS One DOI: 10.1371/journal.pone.0233145 sha: doc_id: 350842 cord_uid: 4m82l5t8 keywords: coronavirus; covid-19; health; medical; personnel; status cache: cord-350842-4m82l5t8.txt plain text: cord-350842-4m82l5t8.txt item: #641 of 672 id: cord-351098-x729wpp7 author: Long, Rachel B. title: Characterizing trends in human-wildlife conflicts in the American Midwest using wildlife rehabilitation records date: 2020-09-11 words: 6365 flesch: 34 summary: The purpose of this study was to examine the value of wildlife rehabilitation facility admissions records for informing understanding of local human-wildlife conflicts and wildlife disease trends by 1) identifying the top reasons for admission to this facility, 2) examining how occurrences as measured by admitted cases may fluctuate monthly and across taxa, and 3) analyzing trends in commonly admitted disease cases. key: cord-351098-x729wpp7 authors: Long, Rachel B.; Krumlauf, Kristi; Young, Anna M. title: Characterizing trends in human-wildlife conflicts in the American Midwest using wildlife rehabilitation records date: 2020-09-11 journal: PLoS One DOI: 10.1371/journal.pone.0238805 sha: doc_id: 351098 cord_uid: x729wpp7 Human-wildlife conflict is difficult to measure, but the analysis of records from wildlife rehabilitation facilities has shown potential as a technique for characterizing human impacts on wildlife. keywords: admission; attacks; cases; cat; disease; facility; human; records; rehabilitation; study; vehicle; wildlife cache: cord-351098-x729wpp7.txt plain text: cord-351098-x729wpp7.txt item: #642 of 672 id: cord-351142-g20f6bxc author: Kiaghadi, Amin title: Assessing COVID-19 risk, vulnerability and infection prevalence in communities date: 2020-10-29 words: 6787 flesch: 42 summary: While Harris County was experiencing fewer cases, and lower rates of transmission relative to the rest of the U.S., starting around mid-June 2020, the pandemic resurged, and the number of COVID-19 cases has increased substantially. To the best of the knowledge of the authors, none of the existing studies provide a holistic perspective on COVID-19 vulnerability. keywords: cases; census; county; covid-19; data; fig; harris; health; number; population; risk; total; tract; vulnerability cache: cord-351142-g20f6bxc.txt plain text: cord-351142-g20f6bxc.txt item: #643 of 672 id: cord-351185-3y3gou6v author: Buckles, Thomas C. title: Rapid exposure of macrophages to drugs resolves four classes of effects on the leading edge sensory pseudopod: Non-perturbing, adaptive, disruptive, and activating date: 2020-05-29 words: 10076 flesch: 39 summary: The microscopic field observed following drug addition in single cell and population measurements represented a small fraction (< 0.2% and < 6%, respectively) of the 8 x 8 mm 2 glass surface area in the observation well. Panels A through D images show representative effects of drug addition on the leading edge pseudopod: (A,B) DICM images of a single cell at t = 0 and 5 min after ibuprofen addition, respectively, illustrating the drug-triggered loss of leading edge pseudopod area; (C,D) fluorescence images of the PIP 3 sensor AKTPH-mRFP in a single cell at t = 0 and 5 min after wortmannin addition, respectively [26, 30] illustrating the drug-triggered loss of the signaling lipid PIP 3 on the leading edge pseudopod. keywords: acetaminophen; adaptation; addition; cell; collapse; concentration; control; drug; edge; effects; fig; ibuprofen; macrophages; pip; plasma; pseudopod; total cache: cord-351185-3y3gou6v.txt plain text: cord-351185-3y3gou6v.txt item: #644 of 672 id: cord-351387-i0zamkpd author: Witte, Katrin title: The Pelargonium sidoides Extract EPs 7630 Drives the Innate Immune Defense by Activating Selected MAP Kinase Pathways in Human Monocytes date: 2015-09-25 words: 4380 flesch: 42 summary: However, the effects of Pelargonium sidoides and a special extract prepared from its roots (EPs 7630) on human immune cells are not fully understood. Therefore, the focus of our current study was to unravel the possible influence of EPs 7630 on human immune cells. keywords: cells; cytokine; eps; human; pbmcs; pelargonium; production; sidoides; tnf cache: cord-351387-i0zamkpd.txt plain text: cord-351387-i0zamkpd.txt item: #645 of 672 id: cord-351868-w4d45fue author: Zuwała, Kaja title: The Nucleocapsid Protein of Human Coronavirus NL63 date: 2015-02-20 words: 6764 flesch: 47 summary: In order to predict polypeptide sequence encompassing the N-terminal domain of N protein from HCoV-NL63 the following sequences of N proteins were aligned: Q6Q1R8 (Uniprot ID), HCoV-NL63; P69596, avian infectious bronchitis virus (IBV, strain Beaudette), sequence referring to the 2bxx crystal structure (Protein Data Bank ID); P69598, IBV (strain Beaudette US), sequence referring to the 2c86 crystal structure; P32923, IBV (strain Gray), sequence referring to the 2gec crystal structure; P03416, murine hepatitis virus (strain A59), To predict polypeptide sequence encompassing the C-terminal domain of N protein from HCoV-NL63 the following sequences of N proteins were aligned: Q6Q1R8, HCoV HCoV-NL63 N Protein NL63; P69596, avian infectious bronchitis virus (IBV, strain Beaudette), sequence referring to the 2ca1 crystal structure; P32923, IBV (strain Gray), sequence referring to the 2ge7 crystal structure; P32923, IBV (strain Gray), sequence referring to the 2ge8 crystal structure; P59595, human SARS coronavirus, sequence referring to the 2cjr crystal structure; P59595, SARS CoV, sequence referring to the 2jw8 solution structure. keywords: analysis; cells; coronavirus; ctd; hcov; human; n protein; nl63; ntd; nucleocapsid; poland; protein; rna; sars; sequence; structure; terminal; ttt cache: cord-351868-w4d45fue.txt plain text: cord-351868-w4d45fue.txt item: #646 of 672 id: cord-351918-pu7i1jfe author: Baek, Yae Jee title: A mathematical model of COVID-19 transmission in a tertiary hospital and assessment of the effects of different intervention strategies date: 2020-10-26 words: 4907 flesch: 47 summary: Other studies about hospital outbreaks from infectious diseases were conducted with many different mathematical models: a multiagent model or SEIR transmission model [26] Fig 6 shows the effectiveness of all intervention scenarios and the effectiveness of the detection of infectious patients, 80.7%, is the highest among the control measures. keywords: covid-19; hospital; model; number; outbreak; patients; screening; transmission cache: cord-351918-pu7i1jfe.txt plain text: cord-351918-pu7i1jfe.txt item: #647 of 672 id: cord-351990-aham72b9 author: Radin, Jennifer M. title: Epidemiology of Pathogen-Specific Respiratory Infections among Three US Populations date: 2014-12-30 words: 4514 flesch: 38 summary: This population is also highly vaccinated for influenza and showed the smallest amount of influenza infection compared with the other two populations. In our 5-24 year olds we found fever, cough, and short time to seeking care to be predictive of influenza infection. keywords: age; fever; infections; influenza; pathogen; populations; rhinovirus; study cache: cord-351990-aham72b9.txt plain text: cord-351990-aham72b9.txt item: #648 of 672 id: cord-352200-i05h8csb author: Xu, Yi title: Transcriptome and Comparative Gene Expression Analysis of Sogatella furcifera (Horváth) in Response to Southern Rice Black-Streaked Dwarf Virus date: 2012-04-27 words: 5289 flesch: 41 summary: During this time, non-viruliferous WBPH, as the control group, were treated identically. Biology and epidemiology of rice virus Southern rice blackstreaked dwarf virus: A new proposed Fijivirus species in the family Reoviridae Molecular characterization of segments S7 to S10 of a southern rice black-streaked dwarf virus isolate from maize in northern China A black-streaked dwarf disease on rice in China is caused by a novel fijivirus Virus taxonomy: classification and nomenclature of viruses. keywords: analysis; expression; figure; genes; infection; pathway; proteasome; protein; rice; rna; srbsdv; table; unigenes; virus; viruses; wbph cache: cord-352200-i05h8csb.txt plain text: cord-352200-i05h8csb.txt item: #649 of 672 id: cord-352219-z245sb3s author: Tallam, Aravind title: Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages date: 2016-02-12 words: 9137 flesch: 37 summary: Gene expression analysis of infected mice resulted in the grouping of differentially expressed genes into different clusters based on the dependence of gene expression on IFNγ or IRF1. Irg1 was classified to the cluster of genes whose expression is mostly dependent on Irf1, but less on IFNγ However, taking the side of the discussion that human macrophages do not express iNOS, IRF1 plays a crucial role in mediating antimicrobial responses through IRG1 gene regulation in human immune cells. keywords: acid; analysis; cad; cells; expression; factor; fig; gene; human; immune; irf1; irg1; lps; macrophages; mouse; network; production; regulators; sirna; transcriptional cache: cord-352219-z245sb3s.txt plain text: cord-352219-z245sb3s.txt item: #650 of 672 id: cord-352222-zq9o66i4 author: Rajatonirina, Soatiana title: Outcome Risk Factors during Respiratory Infections in a Paediatric Ward in Antananarivo, Madagascar 2010–2012 date: 2013-09-12 words: 4140 flesch: 44 summary: We conducted a prospective study in a paediatric ward in Antananarivo from November 2010 to July 2012 including patients under 5 years old suffering from respiratory infections. Respiratory infections are a major cause of infectious diseaserelated morbidity, hospitalisation, and mortality among children under 5 years old worldwide, and particularly in developing countries [1] . keywords: children; hospitalisation; infections; influenza; months; patients; pneumonia; study cache: cord-352222-zq9o66i4.txt plain text: cord-352222-zq9o66i4.txt item: #651 of 672 id: cord-352403-4591ewsa author: Hartwig, Stacey M. title: Depletion of Alveolar Macrophages Ameliorates Virus-Induced Disease following a Pulmonary Coronavirus Infection date: 2014-03-07 words: 3794 flesch: 52 summary: At day 6 p.i., prior to the onset of MHV-1-induced mortality, there was no significant difference between the CL-treated mice and the PBS control mice in total CD4 T cell numbers in the BAL ( Figure 4A ). Because our data indicated a general trend of reduced CD4 and CD8 T cell responses in the lung airways, we hypothesized that AM depletion may have altered the Treg response. keywords: cd4; cd8; cells; infection; lung; mhv-1; mice cache: cord-352403-4591ewsa.txt plain text: cord-352403-4591ewsa.txt item: #652 of 672 id: cord-352447-bc1pf272 author: Nishida, Yu title: Novel prognostic biomarkers of pouchitis after ileal pouch-anal anastomosis for ulcerative colitis: Neutrophil-to-lymphocyte ratio date: 2020-10-26 words: 3483 flesch: 43 summary: The role of the gut microbiome in pouchitis development is indicated by the effectiveness of antibiotics in the treatment of pouchitis, the use of probiotics for its prevention We aimed to evaluate the clinical utility of the NLR for predicting the development of pouchitis after IPAA in UC patients. keywords: analysis; development; disease; ipaa; nlr; patients; pouchitis; study cache: cord-352447-bc1pf272.txt plain text: cord-352447-bc1pf272.txt item: #653 of 672 id: cord-352511-gkm7i62s author: Yamada, Yoshiyuki title: Acquisition of Cell–Cell Fusion Activity by Amino Acid Substitutions in Spike Protein Determines the Infectivity of a Coronavirus in Cultured Cells date: 2009-07-02 words: 5816 flesch: 49 summary: The molecular biology of coronaviruses The biology and pathogenesis of coronavirus Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Bats are natural reservoirs of SARS-like coronaviruses Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immune-mediated Genetic evolution and tropism of transmissible gastroenteritis coronaviruses Circulation of genetically distinct contemporary human coronavirus OC43 strains Replication and morphogenesis of avian coronavirus in Vero cells and their inhibition by momensin Coronavirus IBV: partial amino terminal sequencing of spike polypeptide S2 identifies the sequence Arg-Arg-Phe-Arg-Arg at the cleavage site of the spike precursor propolypeptide of IBV strains Beaudette and M41 Selection of and recombination between minor variants lead to the adaptation of an avian coronavirus to primate cells Emergence of an avian coronavirus infectious bronchitis virus (IBV) mutant with a truncated 3b gene: functional characterization of the 3b gene in pathogenesis and replication Single Amino Acid Mutation in the Spike Protein of Coronavirus Infectious Bronchitis Virus Hampers Its Maturation and Incorporation into Virions at the Nonpermissive Temperature In vitro assembled, recombinant infectious bronchitis viruses demonstrate that the 5a open reading frame is not essential for replication Induction of p53-independent cell cycle arrest at S-and G 2 /M-phase in cells infected with the coronavirus infectious bronchitis virus promotes viral replication Identification of two new polypeptides encoded by mRNA5 of the coronavirus infectious bronchitis virus An Arginine-to-Proline Mutation in a Domain with Undefined Functions within the Helicase Protein (NSP13) is Lethal to the Coronavirus Infectious Bronchitis Virus in Cultured Cells Amino acid residues critical for RNA-binding in the N-terminal domain of the nucleocapsid protein are essential determinants for the replication and infectivity of coronavirus in cultured cells Further characterization of the coronavirus infectious bronchitis virus 3C-like proteinase and determination of a new cleavage site Membrane association and dimerization of a cysteinerich, 16-kDa polypeptide released from the C-terminal region of the coronavirus infectious bronchitis virus 1a polyprotein Coronaviruses from pheasants (Phasianus colchicus) are genetically closely related to coronaviruses of domestic fowl (infectious bronchitis virus) and turkeys The coronavirus spike protein is a class I virus fusion protein: structural and functional characterization of the fusion core complex Murine coronavirus with an extended host range uses heparan sulfate as an entry receptor Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV Feline aminopeptidase N serves as a receptor for feline, canine, porcine, and human coronaviruses in serogroup I A 12-amino acid stretch in the hypervariable region of the spike protein S1 subunit is critical for cell fusion activity of mouse hepatitis virus Furthermore, a G405-D point mutation in the S1 domain, which was acquired during further propagation of Vero-adapted IBV in Vero cells, could enhance the cell–cell fusion activity of the protein. keywords: activity; cell; cell fusion; constructs; coronavirus; fig; fusion; ibv; protein; vero; virus cache: cord-352511-gkm7i62s.txt plain text: cord-352511-gkm7i62s.txt item: #654 of 672 id: cord-352522-qnvgg2e9 author: Langille, Morgan G. I. title: BioTorrents: A File Sharing Service for Scientific Data date: 2010-04-14 words: 2995 flesch: 46 summary: [16] handles large files very well, is actively being developed, and is a very popular method for data transfer. Also, many BitTorrent clients support a distributed hash table (DHT) for peer discovery, which often allows data transfer to continue in the absence of a tracker, further enhancing the reliability over traditional client-server file transfers. keywords: biotorrents; data; datasets; file; peer; sharing; transfer cache: cord-352522-qnvgg2e9.txt plain text: cord-352522-qnvgg2e9.txt item: #655 of 672 id: cord-352564-2j4pjjwk author: Dominguez, Samuel R. title: Human Coronavirus HKU1 Infection of Primary Human Type II Alveolar Epithelial Cells: Cytopathic Effects and Innate Immune Response date: 2013-07-24 words: 4456 flesch: 37 summary: Furthermore, these studies demonstrate that human alveolar cells can be used to isolate and study novel human respiratory viruses that cause lower respiratory tract disease. In parallel to these advances, and as an alternative approach to study HCoV-HKU1, we reasoned that HCoV-HKU1, like SARS-CoV [15] , may be able to infect and be serially propagated in human alveolar cells since this virus is known to cause pneumonia in a subset of patients. keywords: alveolar; cells; coronavirus; hcov; hku1; human; infection; primary; type cache: cord-352564-2j4pjjwk.txt plain text: cord-352564-2j4pjjwk.txt item: #656 of 672 id: cord-352720-z1cvjc2y author: Díaz-Corvillón, Pilar title: Routine screening for SARS CoV-2 in unselected pregnant women at delivery date: 2020-09-29 words: 4063 flesch: 43 summary: All neonates born from mothers with confirmed SARS CoV-2 were isolated and tested for SARS CoV-2 infection. To assess the prevalence of SARS CoV-2 infection in an unselected obstetrical population and to describe their presentation and clinical evolution. keywords: cases; cov-2; infection; patients; population; prevalence; sars; study cache: cord-352720-z1cvjc2y.txt plain text: cord-352720-z1cvjc2y.txt item: #657 of 672 id: cord-353200-5csewb1k author: Jehi, Lara title: Development and validation of a model for individualized prediction of hospitalization risk in 4,536 patients with COVID-19 date: 2020-08-11 words: 4349 flesch: 35 summary: After that date, testing resources were streamlined through a COVID-19 Hotline which followed recommendations from the Centers for Disease Control (recommending to focus on high risk patients as defined by any of the following: Age older than 60 years old or less than 36 months old; on immune therapy; having comorbidities of cancer, end-stage renal disease, diabetes, hypertension, coronary artery disease, heart failure with reduced ejection fraction, lung disease, HIV/AIDS, solid organ transplant; contact with known COVID 19 patients; physician discretion was still allowed). Table 1 provides demographic, exposure, clinical, laboratory, social characteristics, and medication history of COVID-19 patients who were hospitalized versus those who completed their treatment on an outpatient basis in both the DC and VC. keywords: cohort; covid-19; data; disease; health; hospitalization; model; patients; prediction; risk; variables cache: cord-353200-5csewb1k.txt plain text: cord-353200-5csewb1k.txt item: #658 of 672 id: cord-353245-es7b1rs0 author: Song, Deping title: Molecular Characterization and Phylogenetic Analysis of Porcine Epidemic Diarrhea Viruses Associated with Outbreaks of Severe Diarrhea in Piglets in Jiangxi, China 2013 date: 2015-03-19 words: 4286 flesch: 47 summary: To address the genetic/antigenic variations, and phylogenetic characteristics of PEDV strains associated with 2013 Jiangxi PED outbreaks, two representative PEDV strains, designated CH/JX-1/2013 and CH/JX-2/2013 (the GenBank accession numbers are KF760557 and KJ526096, respectively), were used for sequencing the full-length genome. Notably, an amino acid substitution was found in the middle of one neutralizing epitope Phylogenetic trees based on the complete genome, aa sequences of structural proteins and ORF3 of PEDV strains. keywords: diarrhea; epidemic; jx-1/2013; pedv; porcine; strains; virus cache: cord-353245-es7b1rs0.txt plain text: cord-353245-es7b1rs0.txt item: #659 of 672 id: cord-353253-kk2q71vg author: Itokawa, Kentaro title: Disentangling primer interactions improves SARS-CoV-2 genome sequencing by multiplex tiling PCR date: 2020-09-18 words: 3331 flesch: 47 summary: In general, amplicons suffering from primer interactions were expected to drop rapidly as Ta decreases. These amplicons seemed equally weak in all three primer sets rather than specific in N1 primer set. keywords: amplicons; artic; coverage; pcr; primer; set cache: cord-353253-kk2q71vg.txt plain text: cord-353253-kk2q71vg.txt item: #660 of 672 id: cord-353410-tbmtg88k author: Sharma, Shreela V. title: Using a rapid assessment methodology to identify and address immediate needs among low-income households with children during COVID-19 date: 2020-10-01 words: 3947 flesch: 49 summary: Brighter Bites response to high risk families: In response to these aforementioned needs, Brighter Bites pivoted and created an infrastructure and a standardized framework to meet the needs of these high-risk families (see Fig 1) . A tracking database was created, in which all phone calls and family concerns were tracked for each family. keywords: bites; covid-19; families; food; health; needs; risk; survey cache: cord-353410-tbmtg88k.txt plain text: cord-353410-tbmtg88k.txt item: #661 of 672 id: cord-353596-8iqjugcx author: Bédubourg, Gabriel title: Evaluation and comparison of statistical methods for early temporal detection of outbreaks: A simulation-based study date: 2017-07-17 words: 5605 flesch: 49 summary: MMWR Morbidity and mortality weekly report Statistical Challenges Facing Early Outbreak Detection in Biosurveillance Statistical methods for the prospective detection of infectious disease outbreaks: a review Automated biosurveillance data from England and Wales A Statistical Algorithm for the Early Detection of Outbreaks of Infectious Disease An evaluation and comparison of three commonly used statistical models for automatic detection of outbreaks in epidemiological data of communicable diseases Assessing surveillance using sensitivity, specificity and timeliness Comparing aberration detection methods with simulated data Comparing syndromic surveillance detection methods: EARS' versus a CUSUM-based methodology Comparison of various statistical methods for detecting disease outbreaks Statistical algorithms for early detection of the annual influenza peak season in Hong Kong using sentinel surveillance data A simulation model for assessing aberration detection methods used in public health surveillance for systems with limited baselines Evaluation of a method for detecting aberrations in public health surveillance data Comparing early outbreak detection algorithms based on their optimized parameter values A simulation study comparing aberration detection algorithms for syndromic surveillance. One advantage of a simulation study for outbreak detection methods benchmarking is the a priori knowledge of the occurrence of outbreaks, which enables the developpment of a real gold standard. keywords: detection; methods; outbreak; performance; pod; series; surveillance; time cache: cord-353596-8iqjugcx.txt plain text: cord-353596-8iqjugcx.txt item: #662 of 672 id: cord-353730-owcapg8h author: Dietrich, Jes title: Inducing Dose Sparing with Inactivated Polio Virus Formulated in Adjuvant CAF01 date: 2014-06-23 words: 7899 flesch: 48 summary: Manufacturing of both the CAF01 adjuvants, IPV vaccines and IPV-CAF01 vaccines was performed in LAF units. Monovalent IPV showed a slightly negative zeta potential (2 13 mV), whereas the adjuvanted IPV-CAF01 vaccine showed a positive zeta potential of 54 mV. Therefore, in IPV vaccines formulated with CAF01, a binding between antigen and adjuvant is electrostatically favorable. keywords: administration; antibody; caf01; fig; group; immunity; ipv; polio; poliovirus; response; titers; vaccine; virus cache: cord-353730-owcapg8h.txt plain text: cord-353730-owcapg8h.txt item: #663 of 672 id: cord-353866-0r1b44id author: Sun, Hongpeng title: Changes of Adult Population Health Status in China from 2003 to 2008 date: 2011-12-02 words: 3422 flesch: 50 summary: Hence it is imperative to assess population health using indicators that reflect contemporary health issues. However, overall Chinese adult population health status has not been improved due to short time and small proportion of residents performing frequent exercise; hence it seems that the prevalence and burden of chronic diseases will continue to grow. keywords: china; chinese; disease; health; population; prevalence; status; survey cache: cord-353866-0r1b44id.txt plain text: cord-353866-0r1b44id.txt item: #664 of 672 id: cord-353869-l53ms3q8 author: Friesen, Robert H. E. title: New Class of Monoclonal Antibodies against Severe Influenza: Prophylactic and Therapeutic Efficacy in Ferrets date: 2010-02-08 words: 4686 flesch: 40 summary: The results presented here also confirm previously reported data demonstrating the prophylactic and therapeutic efficacy of CR6261 in mice challenged with H5N1 influenza viruses. A recently discovered class of human monoclonal antibodies with the ability to neutralize a broad spectrum of influenza viruses (including H1, H2, H5, H6 and H9 subtypes) has the potential to prevent and treat influenza in humans. keywords: animals; challenge; control; cr6261; ferrets; group; h5n1; influenza; virus cache: cord-353869-l53ms3q8.txt plain text: cord-353869-l53ms3q8.txt item: #665 of 672 id: cord-354000-jxqskt4k author: Warren, Cody J. title: The Antiviral Restriction Factors IFITM1, 2 and 3 Do Not Inhibit Infection of Human Papillomavirus, Cytomegalovirus and Adenovirus date: 2014-05-14 words: 4440 flesch: 41 summary: IFN-b exhibits strong anti-proliferative effects on human cancer cells at concentrations far lower than those for IFN-a [50] . Despite high expression (Fig. 2B) , IFITM1, 2 or 3 did not inhibit virus infection ( Fig. 2A) . keywords: cells; entry; fig; hpv; human; ifitm1; ifn; infection; keratinocytes; virus; viruses cache: cord-354000-jxqskt4k.txt plain text: cord-354000-jxqskt4k.txt item: #666 of 672 id: cord-354052-x4ckzw64 author: Li, Chunhua title: Manipulation of the Porcine Epidemic Diarrhea Virus Genome Using Targeted RNA Recombination date: 2013-08-02 words: 4940 flesch: 46 summary: siRNA knockdown of ORF3 gene in PEDV infected cells reduced the number of particles released from the cells [5] . Virus Genes Outbreak of porcine epidemic diarrhea in suckling piglets Molecular characterization and phylogenetic analysis of porcine epidemic diarrhea virus (PEDV) field isolates in korea PEDV leader sequence and junction sites PEDV ORF3 encodes an ion channel protein and regulates virus production Porcine aminopeptidase N is a functional receptor for the PEDV coronavirus Propagation of the virus of porcine epidemic diarrhea in cell culture Role of proteases in the release of porcine epidemic diarrhea virus from infected cells Derivation of attenuated porcine epidemic diarrhea virus (PEDV) as vaccine candidate Cloning and further sequence analysis of the ORF3 gene of wild-and attenuated-type porcine epidemic diarrhea viruses Enhanced cell fusion activity in porcine epidemic diarrhea virus adapted to suckling mice Retargeting of coronavirus by substitution of the spike glycoprotein ectodomain: keywords: cells; dorf3; fig; gene; genome; gfp; pedv; protein; rluc; rna; vector; virus cache: cord-354052-x4ckzw64.txt plain text: cord-354052-x4ckzw64.txt item: #667 of 672 id: cord-354547-eomm1sl5 author: Wang, Jibin title: Interaction of the Coronavirus Infectious Bronchitis Virus Membrane Protein with β-Actin and Its Implication in Virion Assembly and Budding date: 2009-03-16 words: 6349 flesch: 47 summary: IBV M protein was transiently expressed in H1299 cells grown on 4-well chamber slides (IWAKI). When expressed alone, M protein accumulates in the Golgi complex in the form of homomultimeric complexes [8, 9] . keywords: actin; budding; cells; coronavirus; fig; ibv; interaction; panel; protein; rna; virus cache: cord-354547-eomm1sl5.txt plain text: cord-354547-eomm1sl5.txt item: #668 of 672 id: cord-354763-odzrco6q author: Drake, John M. title: Societal Learning in Epidemics: Intervention Effectiveness during the 2003 SARS Outbreak in Singapore date: 2006-12-20 words: 5746 flesch: 41 summary: Societal learning models were fit to the reciprocal of the mean of observed lags between onset of symptoms and removal c An alternative is to compare the observed outbreak size with the theoretical distribution of outbreak sizes for outbreaks initialized at I 0 keywords: learning; model; outbreak; rate; removal; sars; size; time cache: cord-354763-odzrco6q.txt plain text: cord-354763-odzrco6q.txt item: #669 of 672 id: cord-355259-779czzzx author: Yang, Xiaoyun title: A Beneficiary Role for Neuraminidase in Influenza Virus Penetration through the Respiratory Mucus date: 2014-10-15 words: 6160 flesch: 43 summary: Investigating the role of influenza virus neuraminidase in the cleavage of sialic acid from mucus may shed some light on unravelling the mechanism of influenza pneumonia. Hence the effect of influenza virus neuraminidase on mucus needs to be studied. keywords: diffusion; fig; influenza; influenza virus; mucus; neuraminidase; particles; penetration; respiratory; siv; virus; viruses cache: cord-355259-779czzzx.txt plain text: cord-355259-779czzzx.txt item: #670 of 672 id: cord-355874-nz6eqcdb author: Wang, Le title: A GeXP-Based Assay for Simultaneous Detection of Multiple Viruses in Hospitalized Children with Community Acquired Pneumonia date: 2016-09-14 words: 3069 flesch: 46 summary: The assay covered a broad range of virus targets and a large size of samples were tested. Nucleic acid amplification methods such as PCR and RT-PCR have increasingly been explored for identification of pathogens including virus detection in infectious respiratory diseases [9, 16, 18] . keywords: assay; cap; children; gexp; pcr; viruses cache: cord-355874-nz6eqcdb.txt plain text: cord-355874-nz6eqcdb.txt item: #671 of 672 id: cord-356132-1nisyl5r author: Wang, Huiyao title: The psychological distress and coping styles in the early stages of the 2019 coronavirus disease (COVID-19) epidemic in the general mainland Chinese population: A web-based survey date: 2020-05-14 words: 3023 flesch: 37 summary: The population with younger age (F = 102.04), unmarried (t = 15.28), with history of visiting Wuhan in the past month (t = -40.86), with history of epidemics occurring in the community (t = -10.25), more concern with media reports (F = 21.84), perceived more impacts of the epidemic outbreak (changes over living situations, F = 331.71; emotional control, F = 1863.07; epidemic-related dreams, F = 1642.78) and negative coping style (t = 37.41) had higher level of psychological distress. The general mainland Chinese population with unmarried, history of visiting Wuhan in the past month, perceived more impacts of the epidemic and negative coping style had higher level of psychological distress in the early stages of COVID-19 epidemic. keywords: covid-19; distress; epidemic; population; style cache: cord-356132-1nisyl5r.txt plain text: cord-356132-1nisyl5r.txt item: #672 of 672 id: cord-356364-ipi81ce3 author: Ho, Bo-Lin title: Critical Assessment of the Important Residues Involved in the Dimerization and Catalysis of MERS Coronavirus Main Protease date: 2015-12-14 words: 5061 flesch: 56 summary: Calorimetric titrations of the peptide substrate TQ6-pNA (0.5 mM in a 250-μl syringe) and M pro (6 μM in a 4-ml ampoule) were carried out at 25°C in 10 mM phosphate buffer (pH 7.6). However, thrombin digestion leaves two extra residues (Gly-Ser) at the N-terminus of M pro , resulting in protein with no proteolytic activity (data not shown). keywords: coronavirus; cov; cov m; dimerization; enzyme; fig; mers; pro; sars; substrate cache: cord-356364-ipi81ce3.txt plain text: cord-356364-ipi81ce3.txt