ACKNOWLEDGEMENTS Study funded by Galderma R&D; poster/editorial support provided by Galderma Laboratories, L.P. 

INTRODUCTION

Cleansing skin is an important component of maintaining healthy skin 
as it removes dirt, oil, make up, and helps prepare the skin for topical 
prescription treatments. However, it can also damage the skin by stripping 
out natural moisturizing factors and degrading skin barrier function. For 
patients with rosacea, this is of particular concern due to underlying skin 
barrier disruption and increased skin sensitivity to many ingredients found 
in cleansing products. A foaming cleanser has been specifically developed 
for redness-prone skin (Cetaphil Foaming Face Wash [CFFW]). This formula 
contains caffeine, allantoin, and glycerin to help preserve the skin barier. The 
results of 2 clinical studies that assessed the performance and tolerability of 
CFFW are presented in this poster.

SUBJECTS and METHODS

Study 1: Hydration and Skin Barrier Function 
• Men and women with dry volar forearms
• Product massaged onto pre moistened skin and left for 1 minute
• Product was rinsed with 50 mL of warm water and blotted dry

 - Control had same rinsing and drying procedures
• Corneometer and transepidermal water loss (TEWL) assessed at baseline

and 2, 4, 8, and 24 hourss
Study 2: In Use Efficacy and Tolerability
• Men or women with rosacea and mild to moderate non-transient erythema
• Product used BID for 3 weeks
• Assessments made on day 1, day 1 30 minutes after first use and days 8

and 22 before product use
 - Chromameter, investigator, and subject assessment of redness
 - Investigator and subject tolerability (dermatologic and ophthalmologic)

assessments
· Redness and tolerability assessments made on a 5 point scale of 0

(none), 0.5 (very slight), 1 (slight), 2 (moderate) and 3 (strong)
 - Subject satisfaction

AN EFFECTIVE YET GENTLE FOAMING FACIAL CLEANSER SPECIFICALLY DESIGNED FOR REDNESS-PRONE SKIN
Matthew H Meckfessel, PhD1; Sandrine Teissedre, MSc2; Nadege Lachmann3; Francine Santoro, MD3 

1Galderma Laboratories, L.P., Fort Worth, Texas; 2Galderma R&D, Sophia Antipolis, France; 3Galderma R&D, Egerkingen, Switzerland

CET.P-RD105309-01

SUMMARY

CFFW provides effective, yet gentle cleansing, and is 
an ideal facial cleanser for patients with rosacea

M
ea

n 
Sc

or
e 

(a
.u

.)

Chromameter

Baseline Day 1, 30 Minutes Day 8 Day 22
0

10

5

15

20

25

*

*P  < .05 vs baseline

Figure 4. Chromameter Assessment

Disagree Neutral Agree
Percent of Subjects

Overall, I like the product
very much

Is suitable for sensitive skin

Washes away face make up and
skin impurities

Rinses easily to leave skin soft
and clean

0 50 6010 20 30 40 70 80 90 100

24.2

69.7

66.7

3.0

3.0
3.0

3.0

21.2
9.1

15.2
78.8

90.9

P  < .05 for Agree vs
Disagree for all

Figure 5. Subject Satisfaction

RESULTS

There were no significant changes to skin hydration or skin barrier function 
during the 24 hour period showing CFFW did not disrupt the skin barrier 
(Figures 1 and 2). For the in use study, 33 women enrolled with a mean age 
of 52.1 years. There was no significant change during the study as assessed 
by investigators and subjects (Figure 3). There was a significant worsening 
as assessed by chromameter at day 8 (Figure 4). However, this change 
in erythema is likely not clinically relevant as they were not noted by the 
investigator or subjects. The product was well tolerated with mean scores 
for all parameters less than mild for both dermatologic and ophthalmologic 
assessments (data not shown). Subjects demonstrated high satisfaction 
with the product (Figure 5). Three adverse events were reported and were 
not considered related by the investigator: toothache, suspicion of nervous 
breakdown, and edema of both lower lids.

M
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Co

rn
eo

m
et

er
 (a

.u
.)

CCFW
Control Area

Hour
0

20
22
24
26
28
30
32
34
36
38
40

4 8 12 16 20 24

No significant differences between control and CFFW

M
ea

n 
TE

W
L 

(g
/m

2h
)

CCFW
Control Area

Hour
0

0

2

4

6

8

10

4 8 12 16 20 24

No significant differences between control and CFFW

M
ea

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Sc

or
e

Investigator
Subject

Baseline Day 1, 30 Minutes Day 8 Day 22
0

1

2

3

No significant differences from baseline.

Figure 2. TEWL Assessments

Figure 1. Corneometry Assessments Figure 3. Skin Redness Assessments


	FC17PosterGaldermaMeckfesselEffectiveFoamingCleanser.pdf