72
1

Figure 3. Improvement in the skin texture: decrease in the texture count (S)=p<0.001.

-7% (S)

4.
45

4.
15

Efficacy on firming and contouring effects 
Face volumeFaceScan®

VISIA® (photographs analysis)

Dynaskin® DermaTOP®

Cutometer®

Subjective efficacy and organoleptic properties

Questionnaires: Statistical analysis was performed to determine the variations obtained 
under the effect of the CC by a paired samples t-test. 

3D analysis software

Skin firmness

Skin biomechanical properties

An open label, prospective, clinical study to evaluate the antiaging 
effects and the safety of a novel cosmetic facial day cream.

Fall Clinical Dermatology Conference® October 12-15, 2017. Las Vegas, Nevada, USA

Granger C., Martinez-Masana G., Garre A.
Innovation and Development ISDIN Barcelona Spain

INTRODUCTION
Skin aging is a complex biological process influenced by a 
combination of intrinsic and extrinsic factors determining 
both photo and chronological aging. 
The aim of this study was to evaluate both objective and 
subjective efficacy measurements at D28 and D56 of the 
new cosmetic cream (CC) containing Carnosine, 
palmitoyl oligopeptide, palmitoyl tetrapeptide-7, an 
innovative Alteromonas Ferment Extract (AFE) and 
Hyaluronic Acid (HA).  The tolerance of the CC was 
recorded along the study. 

METHODS

RESULTS  
At D56, there was a significant decrease of the ptosis 
volume (Figure 1 and 2). This effect was measured in 82% 
of the subjects.
At D56 the surface of the skin was smoother (p=0.028) 
(Figure 3) and a reduction of the skin deformation (p<0.001) 
was observed which confirmed the firming effect of the 
product (Figures 4 and 5).
At D28 and D56 skin elasticity significantly improved in 
54% (p=0.008) and 83% (p<0.001) of the subjects, 
respectively (Figure 6).
Assessment of skin complexion on VISIA® at D56 showed a 
reduction of 6% (p=0.010) of spots (brown or red skin lesions, 
including freckles, hyperpigmentation and vascular lesions) 
which contributed of improvement of skin even (Figure 7). 
Subjects reported their satisfaction on perceived efficacy and 
organoleptic properties of the products (Figure 8).  

CONCLUSIONS
The data demonstrated that the novel cosmetic facial 
cream has significant anti-aging effects. After 56 days 
of use, there were demonstrated improvements of 
skin firmness, moisturization, and elasticity. These 
improvements contributed to the overall refining 
effect on the facial contour and an improvement of 
skin complexion. The safety and tolerance of the 
product were good. No adverse event was reported.

REFERENCIAS:
A.Garre, G.Martinez-Masana, J.Piquero-Casals, C.Granger. Redefining 
face contour with a novel anti-aging cosmetic product: An open-label, 
prospective clinical study. Dove Med Press [Accepted].
Dobrev H. Use of Cutometer to assess epidermal hydration. Skin Res 
Technol. 2000 Nov;6(4):239-244.

ISDIN S.A.Provencals, 33 Barcelona Spain

Fi
g

u
re

 3

100

80

60

40

20

0

120

0

-29% 
(S)

Open, intra-individual study

n=33 
45 - 65 y.

D0 D28

CC twice a day

D56

Figure 1. Remodeling effect: decrease in the average volume of the ptosis (S)=p<0.001

Fi
g

u
re

 1

3.90

4.00

4.10

4.40

4.30

4.50

D0

D0 D56 FaceScan® image

D56

4.20

V
o

lu
m

e 
(i

n
 M

l)

Figure 6. Elasticity: increase in the R2 (total recovery of the initial state/final defromation) parameter (S)=p<0.001

Fi
g

u
re

 6

R
2 

va
lu

e 
(i

n
 m

m
)

Figure 2. 7% decrease of ptosis volume after 56 days of use

The blue zone 
characterizes a 
decrease in the 
cheek volume 
so a decrease 
in ptosis

Te
xt

u
re

 c
o

u
n

t

D0 D28 D56

D0 D28 D56

-12% 
(S)

-10% 
(S)

80
3

70
8

Fi
g

u
re

 4

V
o

lu
m

e 
(i

n
 m

m
3 )

0.
57

9

Figure 4 and 5. Firming effect: decrease in the average volume of the skin deformation (S)=p<0.001.

Fi
g

u
re

 5

D
ep

th
 (

in
 m

m
)

D0 D28 D56

-29%
(S)

-34%
(S)0

.8
79

0.
61

6

72
1

80
3

70
8

-34% 
(S)

0.8

0.6

0.4

0.2

0.0

1.0

0.50

0.52

0.54

0.58

0.62

0.56

0.66

0.64

0.68

0.60

D0 D28 D56

60

62

64

61

66

65

67

63

Decrerase in the red spot

D0 D28

-6% (S)

67

63

Figure 7. Less red skin after 56 days. Significant decrease in the red spot, (S)=p<0.001

Fi
g

u
re

 7

R
ed

. s
p

o
t

Figure 8. Product efficacy by self-evaluation questionnaire.

Fi
g

u
re

 8

0.
65

4

+20% 
(S)

+17% 
(S)

0.
56

0

0.
67

3

Recovers elasticity and density

Product efficacy by self-evaluation questionnaire

Firmer

Visibility retightened

More moisturized

Satisfied subjects (%). D56

0 80604020 100

660

680

720

700

800

780

820

740

760


	FC17PosterISDINcosmeticdaycreamGranger.pdf