This study demonstrates daily application of this highly protective sunscreen helps minimize recurrence or development of new AK’s over 6 consecutive months.

S. SEITE, D. MOYAL
La Roche-Posay Dermatological Laboratories, Asnières, France

1. Krutmann J, Berking C, Berneburg M, Diepgen T, Dirschka T, Markus S. New strategies in the prevention of actinic keratosis: a critical review. Skin Pharmacol Physiol: 2015: 28: 281-289
2. Gomes-Neto A, Aguilera P, Prieto L, Seite S, Moyal D, Carrera C, Malvehy J, Puig S. Efficacy of a daily protective moisturizer with high Ultraviolet B and Ultraviolet A. Photoprotection in decreasing ultraviolet damage: Evaluation by reflectance confocal microscopy. Acta Dermatol Venereol, 2017

INTRODUCTION

METHODS

PREVENTION OF ACTINIC KERATOSIS BY A VERY HIGH UVB/UVA 
DAILY PHOTOPROTECTANT

RESULTS
After 6 months, 13% of the patients developed recurrent AKs, had new AKs, or both. The size of the existing lesions didn’t increase. The mean number of sunscreen applications was 1.6 times per day. 
The sunscreen was well tolerated. 

Actinic keratosis

CONCLUSION

PATIENTS
AGE GENDER PHOTOTYPE

NUMBER OF 
TREATED 
LESIONS

AK
LESIONS

TREATMENT

NUMBER OF 
REMAINING 

LESIONS

DELAY OF 
RELAPSE 

(DAYS)

AK 
RELAPSE 
STATUS

NUMBER OF 
RECURRENT 

LESIONS

NUMBER 
OF NEW 
LESIONS

79 Male II 6 Cryo 0 179 Recurrence and new 2 1

68 Male II 4 PDT 1 126 New 1

65 Male II 5 Cryo 18 168 New 4

74 Female IV 3 Cryo 11 172 New 2

62 Male II 3 Cryo 3 116 New 3

71 Male II 4 Cryo 0 114 New 4

53 Female II 4 Cryo 2 62 Recurrence and new 4 4

67 Male II 5 Cryo 2 182 Recurrence 1

69 Male II 3 Cryo 0 50 Recurrence and new 1 6

In patients with relapse (recurrence or new lesions), the total number of lesions at the inclusion (treated and remaining lesions) was significantly higher compared to the patients without relapse. 
In patients without relapse it was noticed that the diameter of the remaining lesions didn’t increase (1.9 mm on average).

REFERENCES

Actinic keratosis (AK) is a common pre-cancerous skin lesion caused by solar radiation exposure. Regular use of sunscreen is recommended to prevent the development of AK. The goal of this study 
is to assess the efficacy of sunscreen with UVB and UVA protection (SPF100, UVAPF49) in preventing AK appearance or recurrence.

70 patients between 45 and 80 years old with AK lesions were included in the study. Lesions (between 2 to 6 lesions) on head, forearms or hands were treated with cryosurgery (85%) or photody-
namic therapy (15%).  Subjects regularly applied the study sunscreen through the course of the 6 month study. Treated and non-treated lesions were followed and observation of new lesions were 
performed over 6 months.  


	FC17PosterLaRocheSeitePreventionOfActinicKeratosis .pdf