SKIN BARRIER FUNCTION AT BASELINE, DAY 7 AND DAY 14 ERYTHEMA AND MELANIN INDEX AT BASELINE, DAY 7 AND DAY 14 1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China, 2La Roche-Posay Laboratroire Dermatologique, Shanghai, China, 3La Roche-Posay Laboratoire Dermatologique, Levallois-Perret, France EFFICACY EVALUATION OF A DERMOCOSMETIC WITH SKIN REPAIR PROPERTIES AFTER FRACTIONAL LASER SURGERY IN ACNE SCARS INTRODUCTION OBJECTIVES MATERIALS & METHODS RESULTS Qian Zhang1, Dong Zhang1, Li Wang1, Rongli Zhang1, Jingyi Wei1, Lin Gao1, Xianghua Zhang2, Delphine Kerob3, Zhongxing Zhang2 Acne scars are the cause for a significant morbidity among dermatology out-patients.1 Insights in the potential of fractional laser treatments have established standard laser procedures to treat acne scars.2 Non-ablative fractional 1565 nm laser therapy is indicated in the reduction of pore size, acne scars, wrinkles and photoageing. However, it also causes a series of changes in skin and soft tissues, such as erythema, swelling, pain, burning and other discomfort.3, 4 The recovery period and potential side effect of post fractional laser may be important, post-laser care using dermocosmetics (DC) is highly indicated to increase the outcome of laser procedures.5, 6 The post-laser application of a specifically developed dermocosmetic balm for 14 days improves skin hydration, reduces procedure-related complications, and promotes the early recovery of skin damage after fractional laser operation of acne scars. 84 adults (76 women, 8 men) who underwent acne scar fractional laser were included in this open label study. The population was equally randomized into an active group receiving the DC balm and control group receiving a routine facial care. The sebum content (SC), cuticle water content (CWC) and transepidermal water loss (TEWL) were measured using instrumental means on the 1st day before the procedure (Baseline), on the 7th day after the procedure (Day 7) and 14th day after the procedure (Day 14), respectively. The lesional erythema and melanin index was assessed using a skin image analyzer. The occurrence of post-laser complications within 14 days after the procedure was recorded. CONCLUSION This study evaluated the clinical efficacy and safety of a DC balm in the skin repairing process after fractional laser therapy in acne scars. References 1. Tan J, Beissert S, Cook-Bolden F, Chavda R, Harper J, Hebert A, et al. Impact of Facial Atrophic Acne Scars on Quality of Life: A Multi-country Population-Based Survey. Am J Clin Dermatol. 2022;23(1):115-23. 2. Sadick NS, Cardona A. Laser treatment for facial acne scars: A review. J Cos7met Laser Ther. 2018;20(7-8):424-35. 3. Alexis AF, Coley MK, Nijhawan RI, Luke JD, Shah SK, Argobi YA, et al. Nonablative Fractional Laser Resurfacing for Acne Scarring in Patients With Fitzpatrick Skin Phototypes IV-VI. Dermatol Surg. 2016;42(3):392-402. 4. Degitz K. [Nonablative fractional lasers: Acne scars and other indications]. Hautarzt. 2015;66(10):753-6. 5. Guerrero D. Dermocosmetic management of hyperpigmentations. Ann Dermatol Venereol. 2012;139 Suppl 4:S166-9. 6. Fabbrocini G, Rossi AB, Thouvenin MD, Peraud C, Mengeaud V, Bacquey A, et al. Fragility of epidermis: acne and post-procedure lesional skin. J Eur Acad Dermatol Venereol. 2017;31 Suppl 6:3-18. Funding: This study was funded by La Roche-Posay Laboratoire Dermatologique, China. Acknowledgments: The authors acknowledge the editing assistance of Karl Patrick Göritz, SMWS France and the art work of Dominique Poisson, France. Figure 1 Figure 2 Subjects were aged between 24 and 50 years with a mean age of 39.5±8.6 years. The control group (40.03±12.65 years) was somewhat older than the DC balm group (38.76±14.09 years). 14 days after the procedure, the total effective rates of the DC balm and the control group were similar (97.6% and 92.9%, respectively). 14 days after the procedure, SC and CWC levels in the DC balm group were significantly (p<0.001) higher than in the control group (SC: 87.11±4.4µg/cm² vs 80.29±3.52 μg/cm² CWC: 22.31±3.62% vs 18.95±3.15%; Figure 1). Conversely, the TEWL in the DC balm group was significantly less important than in the control group (14.94±3.62 g•m–2•h–1 vs 23.38±4.04 g•m–2•h–1, p<0.001); a significant improvement was observed as early as after 7 days (Figure 1). After 7 and 14 days of use, the erythema and melanin index were significantly (all p<0.05) lower in the DC balm than in the control (Figure 2). The incidence of post-laser complications was significantly (p<0.035) higher in the control (23.8%) than in the DC balm group (7.1%). 68.3 79.7 87.1 69.2 74.3 80.3 0 20 40 60 80 100 Baseline Day 7 Day 14 µg /cm ² 6.8 17.6 22.3 6.7 12.2 19.0 0 5 10 15 20 25 30 Baseline Day 7 Day 14 pe rc en ta ge 28.7 14.9 12.2 30.0 23.4 17.3 0 10 20 30 40 Baseline Day 7 Day 14 g· m –2 ·h –1 DC balm Control SEBUM CONCENTRATION CUTICLE WATER CONTENT TRANSEPIDERMAL WATER LOSS Baseline Day 7 Day 14 Baseline Day 7 Day 14 DC balm Control EVOLUTION OF THE ERYTHEMA INDEX EVOLUTION OF THE MELANIN INDEX BETWEEN BASELINE AND DAY 28 312.6* 323.8* 317.5*309.0 360.0 348.8 0 100 200 300 400 500 ar bit ra ry u nit 258.3* 221.7* 218.4* 260.4 256.4 244.3 0 50 100 150 200 250 300 350 ar bit ra ry u nit The difference between the DC balm and the control regimen was statistically significant (p<0.001) for all parameters at both post-baseline visits in favour of the DC balm. 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