Ana Du, Susana Raab, Margarita Yatskayer, Stephen Lynch

L’Oréal Research and Innovation, Clark, NJ USA

A Split-Face Design Clinical Trial to Evaluate the Efficacy of a Masque when Used 
Post-Full Face Fraxel® Laser Treatment

INTRODUCTION

Factors such as dermatological or aesthetic
procedures, sun or wind exposure, and
environmental aggressors can catalyze a state of
temporary skin reactivity which leads to the
appearance of redness, heat sensations and
general discomfort. The goal of the present study
was to evaluate the clinical effects of a facial
masque designed to comfort and soothe skin
following a popular aesthetic procedure.

METHODS

Graph 1: Signs and symptoms as reported by the subjects after masque 
application and rinse-off.

RESULTS

Figure 2: Subject showed similar improvement in the appearance of 
redness to those of the entire panel at post masque rinse-off.

Baseline/Post Fraxel® Post masque application

Figure 1: Thermal imaging of the
treated (subject’s left) and untreated
(subject’s right) sites at baseline (post-
laser), post-product application and
rinse off.

The results indicated that the tested masque was effective
in improving the appearance of redness (Figure 2) and
reducing pain/discomfort, burning, heat sensation, and
tightness on the treated side post-product application
and/or post-product rinse off when compared to baseline
and between the treated and untreated sides. (Graph 1)

Results of thermal imaging showed a statistically significant
reduction in skin surface temperature on the cheek of the
treated side at post-product application and rinse off when
compared to baseline (post-laser) and when compared to
the untreated side of the face. (Figure 1)

Subjects indicated feeling cool and feeling calmed/soothed 
immediately upon masque application.

CONCLUSIONS

5292

This single center, split-face clinical trial was
conducted over the course of 1 day on thirty
(30) female subjects between the ages of 32-
60.

Each subject was treated with a Fraxel® laser
treatment. The tested masque was applied by a
clinician on the assigned side of the face
according to a predetermined randomization.

Clinical evaluations of the appearance of
redness, dryness, flaking/peeling and swelling
were conducted pre-laser, post-laser, post-
product application and post-product rinse off.

Local cutaneous tolerability was evaluated by
subject assessment of signs and symptoms of
pain/discomfort, itching, burning, heat sensation
and tightness separately for the facial halves.

Digital images were taken at each of the
designated study time points using a thermal
camera and VISIA CR™ system.

Subjects also completed a questionnaire in
regards to the cooling/calming/soothing effects
post masque application.

-70

-60

-50

-40

-30

-20

-10

0

M
ea

n 
%

 R
ed

uc
tio

n

Pain/discomfort Burning Heat sensation Tightness

*

*

*
*

*

* * *

*statistically significant at P>0.05 when compared to baseline and untreated site

Post masque rinse-off

Ba
se

lin
e/

Po
st

 F
ra

xe
l®

Post m
asque rinse-off

TreatedUntreated

The tested masque was effective in improving the
appearance of redness following masque application and
after rinse-off, reduced skin temperature and soothed signs
of discomfort such as pain, burning, heat sensation, and
tightness immediately upon masque application, following a
Fraxel® procedure.

Treated TreatedUntreated Untreated

Post masque Post rinse-off


	FC17PosterSkinceuticalsDuASplitFaceDesignClinicalTrial.pdf