PowerPoint Presentation PRESENTED AT THE FALL CLINICAL DERMATOLOGY CONFERENCE FOR PAs & NPs (FCPANP23), JUNE 9–11, 2023, ORLANDO, FL, USA Figure 8. Patient-Reported Work Impact of SD N/A: not applicable; SD: seborrheic dermatitis. “The symptoms of my seborrheic dermatitis make me less likely to want to interact with people at work” “I feel I would be further along in my career if I didn't have seborrheic dermatitis” 58% agree “The symptoms of my seborrheic dermatitis have made me less confident at work” “The symptoms of my seborrheic dermatitis made me choose a different career path than I originally planned” 61% agree 59% agree 47% agree 50% Yes No N/A Ever missed work because of SD symptoms 47% YES 3% Figure 5. Patient- and HCP-Reported Social Life and Personal Relationships Impact of SD HCP: healthcare provider; SD: seborrheic dermatitis. Figure 2. HCP Demographics HCP: N=601 included dermatologists and NPs and PAs specializing in dermatology. HCP: healthcare provider; NP/PA: nurse practitioner/physician assistant; SD: seborrheic dermatitis. Figure 1. Patient Demographics N=300. Percentages may not add up to 100% due to rounding and acceptance of multiple responses. REFERENCE 1. Dessinioti C, Katsambas A. Clin Dermatol 2013;31:343–351. ACKNOWLEDGEMENTS • This study was supported by Arcutis Biotherapeutics, Inc. • Thank you to the investigators and their staff for their participation in the trial • We are grateful to the study participants and their families for their time and commitment • Writing support was provided by Lauren Ramsey, PharmD, Alligent Biopharm Consulting LLC, and funded by Arcutis Biotherapeutics, Inc. DISCLOSURES RC, LA, CH, MA, and MZ are investigators and/or consultants for Arcutis Biotherapeutics, Inc. and received grants/research funding and/or honoraria; DHC, DH, and MS are employees of Arcutis Biotherapeutics, Inc. Additional disclosures provided on request. Raj Chovatiya,1 Lakshi Aldredge,2 Candrice Heath,3 Moises Acevedo,4 David H. Chu,5 Diane Hanna,5 Melissa Seal,5 Matthew Zirwas6 1Northwestern University, Chicago, IL, USA; 2Veterans Administration Portland Health Care System, Portland, OR, USA; 3Temple University, Philadelphia, PA, USA; 4Park Plaza Dermatology, New York, NY, USA; 5Arcutis Biotherapeutics, Westlake Village, CA, USA; 6Dermatologists of the Central States, Probity Medical Research, and Ohio University, Bexley, OH, USA Patient and Healthcare Provider Perspectives on the Disease Burden of Seborrheic Dermatitis in the United States: Results From a National Survey INTRODUCTION • Seborrheic dermatitis (SD) is a common chronic inflammatory skin disease with a worldwide prevalence of up to 5%1 • While SD is common, the physical and emotional burdens of SD have not been well characterized • The authors developed an online survey, conducted by the Harris Poll, to gain deeper insight into experiences and attitudes towards the disease among patients with SD and dermatology healthcare providers (HCPs) • This poster reports patient and HCP perspectives on the physical and emotional burden of SD METHODS • The patient survey was conducted online from December 2021 through January 2022 among US adults diagnosed with SD by an HCP – Results for age, gender, education, race/ethnicity, region, income, household size, and marital status were weighted, when necessary, to align the data with actual proportions in the population – A propensity score variable was also included to adjust for respondents’ propensity to be online • The HCP survey was conducted online from December 2021 through January 2022 among HCPs specializing in dermatology (including dermatologists, nurse practitioners [NPs], and physician assistants [PAs]) who see ≥1 patient per week and ≥1 patient with SD per year – For dermatologists, results for years in practice, gender, and region were weighted, when necessary, to align the data with actual proportions in the population – For NPs/PAs, raw data were not weighted and are therefore only representative of the individuals who completed the survey RESULTS • The average age of patients in the survey was 40 years and 55% were male (Figure 1) • 67% of the HCPs were physicians, 24% were PAs, and 10% were NPs (Figure 2) – The mean number of years in practice was 3.1 and the mean number of patients seen per week, for all skin conditions, was 158 • The majority of patients (71%) reported their symptoms as being moderate in severity – HCPs may be underestimating the percentage of patients experiencing moderate symptoms • Patients reported living with SD for an average of 3.6 years, with 20% waiting ≥6 years before seeking SD treatment (Figure 3) • Almost half of patients reported that SD negatively impacts their emotional (49%) and physical (42%) well-being “a lot/a great deal” – However, among the 85% of HCPs who assessed quality of life (n=511), only 32% said living with SD has “a lot/a great deal” of negative impact on patients’ lives • Patients with SD reported significant mental health impacts (Figure 4) – 77% reported anxiety, 72% reported depression, and 69% reported anxiety about interacting with other people – HCPs agreed that SD symptoms make patients feel anxiety (79%), depression (70%), and anxiety about interacting with other people (84%) • SD has a significant negative impact on patients’ social life/interactions (91%) and personal relationships (83%) (Figure 5) – >70% of patients said SD can be isolating and other people around them did not understand the negative impact their SD symptoms have on their daily life – 86% of HCPs agreed that others did not understand the negative impact of SD on patients’ lives • 82% of patients agreed that they feel embarrassed when people comment on their SD symptoms (Figure 5) • 77% of patients agreed with the statement “My seborrheic dermatitis symptoms make people think that I have poor hygiene” (Figure 5) – HCPs agreed that patients feel embarrassed when someone comments on their SD symptoms (97%) and that patients’ SD symptoms make other people think they have poor hygiene (88%) • Patients reported that SD has “a lot/a great deal” of negative impact on several aspects of their day-to-day life (Figure 6) • Almost all HCPs agreed that SD has “a lot/a great deal” of negative impact on their patients’ day-to-day life (Figure 7) CONCLUSIONS • While most patients described their SD as moderate to severe and having a significant impact on their quality of life, HCPs underestimated the patient-reported severity and level of impact on patients’ quality of life – Patients’ social life and personal relationships suffer due to SD and most patients said others do not understand the negative impact of SD on their life • Patients reported SD causes a considerable impact on their day-to-day life, including physical appearance, hygiene routine, clothing choices, and sleep • Most patients said SD negatively impacts their self-esteem and multiple aspects of their mental health, causing anxiety and depression • The majority of patients reported SD impairs their ability to do their job, with almost half of patients having ever missed work due to SD symptoms • These insights highlight the immense patient burden associated with SD, impacting patients’ emotional, social, and work lives Figure 3. Patient- and HCP-Reported Disease Severity Patients: N=300; HCPs: N=601. HCP: healthcare provider. Mean number of patients seen in a typical WEEK Mean number of patients with SD seen per YEAR 323.7 patients 157.7 patients Gender Men: 41% Women: 59% Mean years of practice NP/PA: 2.9 years Dermatologist: 3.3 years Patient-reported severity HCP-reported severity Mild Moderate Severe 71% 16%13% 19% 40% 41% Figure 4. Patient- and HCP-Reported Mental Health Impact of SD HCP: healthcare provider; SD: seborrheic dermatitis. Figure 7. Percent of HCPs Who Reported “A Lot/A Great Deal” of Negative Impact on Their Patients HCP: healthcare provider. Figure 6. Percent of Patients Who Reported “A Lot/A Great Deal” of Negative Impact 0 20 40 60 80 100 33% 41% 44% 46% 48% 48% 54% % Patients Ability to sleep Social life Personal relationships Day-to-day life Clothing choices Daily hygiene routine Physical appearance/ feeling attractive Physical appearance /feeling attractive Clothing choices Daily hygiene routine 0 20 40 60 80 100 % H CP s 95%96% 91% 97% of HCPs agree 88% of HCPs agree “My seborrheic dermatitis symptoms make people think that I have poor hygiene” 19% 14% 31% 25% 28% 31% 13% 13% 91% 83% Social life/ social interactions My personal relationships A little negative impact Some negative impact A lot of negative impact A great deal of negative impact “I feel embarrassed when people comment on my seborrheic dermatitis symptoms” 77% of patients 82% of patients • 73% of patients stated living with SD negatively impacts their ability to do their job, specifically agreeing that (Figure 8): – They would be further along in their career if they didn’t have SD (61%) – SD symptoms made them less confident at work (59%) – SD symptoms made them less likely to want to interact with people at work (58%) – SD made them choose a different career path than they originally planned (47%) • 47% of patients reported ever missing work due to SD symptoms Mean age 40 years Gender Men: 55% Women: 45% Race/ethnicity Black or White: 52% African American: 12% Hispanic: 31% Asian: 3% Anxiety Depression Social anxiety “My seborrheic dermatitis symptoms cause me anxiety” “My seborrheic dermatitis symptoms make me feel depressed” “My seborrheic dermatitis symptoms make me anxious about interacting with other people” 90% of patients said living with SD negatively impacts their self-esteem, with 54% of them reporting it has “a lot/a great deal” of negative impact Self-esteem 79% of HCPs agree 77% of patients 70% of HCPs agree 72% of patients 84% of HCPs agree 69% of patients Patient and Healthcare Provider Perspectives on the Disease Burden of Seborrheic Dermatitis in the United States: Results From a National Survey << /ASCII85EncodePages false /AllowTransparency false /AutoPositionEPSFiles true /AutoRotatePages /None /Binding /Left /CalGrayProfile (Gray Gamma 2.2) /CalRGBProfile (sRGB IEC61966-2.1) /CalCMYKProfile (U.S. Web Coated \050SWOP\051 v2) /sRGBProfile (sRGB IEC61966-2.1) /CannotEmbedFontPolicy /Warning /CompatibilityLevel 1.4 /CompressObjects /Tags /CompressPages false /ConvertImagesToIndexed true /PassThroughJPEGImages true /CreateJobTicket false /DefaultRenderingIntent /Default /DetectBlends true /DetectCurves 0.0000 /ColorConversionStrategy /UseDeviceIndependentColor /DoThumbnails false /EmbedAllFonts true /EmbedOpenType false /ParseICCProfilesInComments true /EmbedJobOptions true /DSCReportingLevel 0 /EmitDSCWarnings false /EndPage -1 /ImageMemory 1048576 /LockDistillerParams false /MaxSubsetPct 100 /Optimize false /OPM 1 /ParseDSCComments true /ParseDSCCommentsForDocInfo true /PreserveCopyPage true /PreserveDICMYKValues true /PreserveEPSInfo true /PreserveFlatness false /PreserveHalftoneInfo false /PreserveOPIComments true /PreserveOverprintSettings true /StartPage 1 /SubsetFonts true /TransferFunctionInfo /Apply /UCRandBGInfo /Preserve /UsePrologue false /ColorSettingsFile () /AlwaysEmbed [ true /Museo /MuseoSans300 /MuseoSans700 ] /NeverEmbed [ true ] /AntiAliasColorImages false /CropColorImages false /ColorImageMinResolution 300 /ColorImageMinResolutionPolicy /OK /DownsampleColorImages true /ColorImageDownsampleType /Bicubic /ColorImageResolution 300 /ColorImageDepth -1 /ColorImageMinDownsampleDepth 1 /ColorImageDownsampleThreshold 1.00000 /EncodeColorImages false /ColorImageFilter /DCTEncode /AutoFilterColorImages true /ColorImageAutoFilterStrategy /JPEG /ColorACSImageDict << /QFactor 0.15 /HSamples [1 1 1 1] /VSamples [1 1 1 1] >> /ColorImageDict << /QFactor 0.15 /HSamples [1 1 1 1] /VSamples [1 1 1 1] >> /JPEG2000ColorACSImageDict << /TileWidth 256 /TileHeight 256 /Quality 30 >> /JPEG2000ColorImageDict << /TileWidth 256 /TileHeight 256 /Quality 30 >> /AntiAliasGrayImages false /CropGrayImages false /GrayImageMinResolution 300 /GrayImageMinResolutionPolicy /OK /DownsampleGrayImages true /GrayImageDownsampleType /Bicubic /GrayImageResolution 300 /GrayImageDepth -1 /GrayImageMinDownsampleDepth 2 /GrayImageDownsampleThreshold 1.00000 /EncodeGrayImages false /GrayImageFilter /DCTEncode /AutoFilterGrayImages true /GrayImageAutoFilterStrategy /JPEG /GrayACSImageDict << /QFactor 0.15 /HSamples [1 1 1 1] /VSamples [1 1 1 1] >> /GrayImageDict << /QFactor 0.15 /HSamples [1 1 1 1] /VSamples [1 1 1 1] >> /JPEG2000GrayACSImageDict << /TileWidth 256 /TileHeight 256 /Quality 30 >> /JPEG2000GrayImageDict << /TileWidth 256 /TileHeight 256 /Quality 30 >> /AntiAliasMonoImages false /CropMonoImages false /MonoImageMinResolution 1200 /MonoImageMinResolutionPolicy /OK /DownsampleMonoImages true /MonoImageDownsampleType /Bicubic /MonoImageResolution 450 /MonoImageDepth -1 /MonoImageDownsampleThreshold 1.00000 /EncodeMonoImages false /MonoImageFilter /CCITTFaxEncode /MonoImageDict << /K -1 >> /AllowPSXObjects false /CheckCompliance [ /None ] /PDFX1aCheck false /PDFX3Check false /PDFXCompliantPDFOnly false /PDFXNoTrimBoxError true /PDFXTrimBoxToMediaBoxOffset [ 0.00000 0.00000 0.00000 0.00000 ] /PDFXSetBleedBoxToMediaBox true /PDFXBleedBoxToTrimBoxOffset [ 0.00000 0.00000 0.00000 0.00000 ] /PDFXOutputIntentProfile () /PDFXOutputConditionIdentifier () /PDFXOutputCondition () /PDFXRegistryName () /PDFXTrapped /False /CreateJDFFile false /Description << /ENU ([Based on 'EPG PRESS RGB'] [Based on 'EPG PRESS RGB'] [Based on '[Press Quality]'] Use these settings to create Adobe PDF documents best suited for high-quality prepress printing. Created PDF documents can be opened with Acrobat and Adobe Reader 5.0 and later.) >> /Namespace [ (Adobe) (Common) (1.0) ] /OtherNamespaces [ << /AsReaderSpreads false /CropImagesToFrames true /ErrorControl /WarnAndContinue /FlattenerIgnoreSpreadOverrides false /IncludeGuidesGrids false /IncludeNonPrinting false /IncludeSlug false /Namespace [ (Adobe) (InDesign) (4.0) ] /OmitPlacedBitmaps false /OmitPlacedEPS false /OmitPlacedPDF false /SimulateOverprint /Legacy >> << /AddBleedMarks false /AddColorBars false /AddCropMarks true /AddPageInfo true /AddRegMarks false /BleedOffset [ 9 9 9 9 ] /ConvertColors /ConvertToRGB /DestinationProfileName (sRGB IEC61966-2.1) /DestinationProfileSelector /UseName /Downsample16BitImages true /FlattenerPreset << /PresetSelector /MediumResolution >> /FormElements false /GenerateStructure true /IncludeBookmarks false /IncludeHyperlinks false /IncludeInteractive false /IncludeLayers false /IncludeProfiles false /MarksOffset 6 /MarksWeight 0.250000 /MultimediaHandling /UseObjectSettings /Namespace [ (Adobe) (CreativeSuite) (2.0) ] /PDFXOutputIntentProfileSelector /DocumentCMYK /PageMarksFile /RomanDefault /PreserveEditing true /UntaggedCMYKHandling /UseDocumentProfile /UntaggedRGBHandling /LeaveUntagged /UseDocumentBleed false >> << /AllowImageBreaks true /AllowTableBreaks true /ExpandPage false /HonorBaseURL true /HonorRolloverEffect false /IgnoreHTMLPageBreaks false /IncludeHeaderFooter false /MarginOffset [ 0 0 0 0 ] /MetadataAuthor () /MetadataKeywords () /MetadataSubject () /MetadataTitle () /MetricPageSize [ 0 0 ] /MetricUnit /inch /MobileCompatible 0 /Namespace [ (Adobe) (GoLive) (8.0) ] /OpenZoomToHTMLFontSize false /PageOrientation /Portrait /RemoveBackground false /ShrinkContent true /TreatColorsAs /MainMonitorColors /UseEmbeddedProfiles false /UseHTMLTitleAsMetadata true >> ] >> setdistillerparams << /HWResolution [2400 2400] /PageSize [612.000 792.000] >> setpagedevice