ACKNOWLEDGEMENTS: Medical writing support was provided by Prescott Medical Communications Group (Chicago, IL) with financial support from Ortho Dermatologics; Ortho Dermatologics is a division of Bausch Health US, LLC | Presented at Winter Clinical Dermatology Conference 2020 • January 17-22, 2020 • Kohala Coast, HI SYNOPSIS ◾ Psoriasis is a chronic, immune-mediated disease that can have frequent exacerbations and remissions1 ◾ Treatment decisions for psoriasis can be complex, with considerations including patient and provider preferences, patient goals, psychosocial factors, comorbidities, and financial burden2 ◾ Topicals are considered first-line therapy for mild disease3 and are having an increasing role in moderate- to-severe psoriasis as an integral part of combination therapy METHODS ◾ The National Psoriasis Foundation, on behalf of Ortho Dermatologics, deployed an online survey developed by Ortho Dermatologics to the patient community through the NPF MyStudies e-newsletter ◾ The survey was available for approximately 2 months starting in the first quarter of 2018 RESULTS ◾ The survey included a total of 314 respondents, with a 99.4% completion rate ◾ Of the respondents, 86.9% were diagnosed with psoriasis >5 years ago (Table 1) ◾ Over three-fourths of respondents reporting having the following body parts typically affected by plaque psoriasis: scalp, arms, and legs (Table 1) ◾ Multiple treatments were common in this group, with 61.6% of patients having used ≥5 treatments or products; 16.1% had used more than 15 (Table 1) Treatment of Psoriasis: A Survey on Patient Preference and Satisfaction FIGURE 1. Previous and Current Treatments 100% 80% 60% 40% 20% 0% 100.0% 87.1% Topical Medications 54.0% 15.8% Phototherapy 41.7% 12.2% Oral Medications 38.2% 21.2% Biologic Medications 14.2% 8.4% Other 2.3% 5.5% I’m not currently using anything Previous Treatments Current Treatments P e rc e n ta g e o f P a rt ic ip a n ts Questions: What, if anything, have you used in the past to treat your plaque psoriasis (Select all that apply)? What, if anything, are you currently using to treat your plaque psoriasis (Select all that apply)? A total of 0.6% of respondents replied “Don’t know” for the question on previous treatments. FIGURE 2. Openness to Trying New Treatments Somewhat open (34.3%) 93.2% Open to trying new treatments Very open (25.2%) Not very open (5.2%) Extremely open (33.7%) Not at all open (1.6%) Question: How open are you to trying new treatments for your plaque psoriasis? FIGURE 3. Satisfaction with Current Psoriasis Treatment (A) and Reasons for Lack of Satisfaction (B) Extremely (1.9%) A. Overall Satisfaction with Treatment B. Reasons for Lack of Treatment Satisfaction Very (11.7%) Somewhat (39.8%) Not very (31.1%) Not at all (15.5%) 8.9% 4.9% 4.1% 74.8% 5.7% 1.6% My treatment is not effective enough I am concerned about side effects I am concerned about long term safety My treatment isn’t easy to use I don’t like how often I need to use my treatment Other Questions: Overall, how satisfied are you with your current plaque psoriasis treatment? Which, if any, of the following reasons explains why you are not satisfied with your current plaque psoriasis treatment? FIGURE 4. Respondents That Would Have Continued Topical Treatment if it Was Effective (n=92) I would have continued using the topical (54.3%) I would have still started a systemic or biologic (28.3%) I don’t know (14.1%) Not applicable (3.3%) Of the 92 participants that had previously used topical treatment and were currently taking a biologic or systemic treatment, most (n=73) were also still using topical treatment. Question: If your topical treatment had been more effective, would you have continued to use it instead of using a systemic or biologic, or would you have still started a systemic or biologic? ◾ CONCLUSIONS ◾ Most survey respondents had moderate-to- severe psoriasis with a duration of over 5 years ◾ All respondents had used topical treatments in the past, and the vast majority were currently using topicals to treat their psoriasis ◾ Patient satisfaction was low, with lack of effectiveness being the main driver of dissatisfaction ◾ Of individuals who did not achieve sufficient response to topical treatment, over half would have continued to use their topical treatment over starting a systemic/biologic if the topical had been more effective ◾ These survey results suggest that patients are extensively using topical treatments to control their psoriasis, and that topical treatments, if more effective, would be preferred by most patients over systemic or biologic treatments REFERENCES 1. Nestle FO, et al. N Engl J Med. 2009;361(5):496-509. 2. Visconti, et al. J Comp Eff Res. 2019;8(12):947-949. 3. Menter, et al. J Am Acad Dermatol. 2009;60(4):643-659. AUTHOR DISCLOSURES Dr. Lawrence Green has served as a speaker, consultant, and/or investigator for: Arcutis, Abbvie, Amgen, Celgene, Dermavant, Jannsen, Lilly, MC2, Novartis, Ortho Dermatologics, Sienna, SunPharma, UCB. Dr. April Armstrong has served as a research investigator and/or consultant to AbbVie, Janssen, Lilly, Leo, Novartis, UCB, Ortho Dermatologics, Dermira, Sanofi, Regeneron, BMS, Dermavant, and Modernizing Medicine. Dr. Craig F Teller has nothing to disclose. Dr. Stacie Bell is an employee of the National Psoriasis Foundation. Dr. Tina Lin is an employee of Ortho Dermatologics and may hold stock and/or stock options in its parent company. TABLE 1. Respondent Characteristics % of respondents Survey Respondents (N=314) First diagnosed with plaque psoriasis Within past year 1.3 1 – 3 years ago 4.5 3 – 5 years ago 7.4 >5 years ago 86.9 Severity of disease (self-classified) Mild 15.8 Moderate 53.1 Severe 30.9 Body parts commonly affected by psoriasis (>50% respondents) Scalp 78.5 Arms 75.6 Legs 75.2 Body 61.4 Total number of treatments ever used 1 2.3 2 – 5 36.1 5 – 10 31.0 10 – 15 14.5 >15 16.1 ◾ All patients had previously used topical medication(s), with current therapies primarily comprising topicals (87.1%) and biologics (21.2%; Figure 1) ◾ Nearly all respondents (93.2%) were open to trying new treatments (Figure 2; blue regions) ◾ Only 13.6% of respondents were very or extremely satisfied with their current plaque psoriasis treatment, with the lack of satisfaction primarily due to treatment not being effective enough (Figure 3) ◾ Of the 92 participants that had previously been on topical treatment and were currently on a systemic or biologic, over half stated that they would have preferred continuing their topical instead of starting a systemic/biologic treatment if their treatment was more effective (Figure 4) Lawrence Green, MD1; April Armstrong, MD, MPH2; Craig F Teller, MD3; Stacie Bell, PhD4; Tina Lin, PharmD5 1George Washington University School of Medicine, Washington, DC; 2Keck School of Medicine, University of Southern California, Los Angeles, CA; 3Bellaire Dermatology Associates, Houston, TX; 4National Psoriasis Foundation; 5Ortho Dermatologics*, Bridgewater, NJ *Ortho Dermatologics is a division of Bausch Health US, LLC.