RESULTS Figure 1. Patient flow TIL, tildrakizumab. • The patient flow from randomization through the extension study for reSURFACE 1 and reSURFACE 2 is shown in Figure 1 Table 1. Baseline demographics for patients entering extension reSURFACE 1 reSURFACE 2 TIL 100 mg (n = 239) TIL 200 mg (n = 267) TIL 100 mg (n = 382) TIL 200 mg (n = 349) Sex, male, n (%) 159 (66.5) 183 (68.5) 291 (76.2) 242 (69.3) Age, mean ± SD, years 46.9 ± 13.0 47.1 ± 13.0 44.2 ± 13.2 45.6 ± 12.8 Race, White, n (%) 163 (68.2) 173 (64.8) 352 (92.1) 329 (94.3) Baseline PASI score, mean ± SD 20 ± 7.6 21.3 ± 9.6 19.8 ± 7.6 19.3 ± 6.9 Weight, mean ± SD, kg 87.1 ± 24.4 87.8 ± 24.2 88.4 ± 21.4 89.0 ± 21.5 Body surface area, mean ± SD 30.2 ± 17.5 31.7 ± 19.6 32.6 ± 18.0 30.1 ± 15.8 PASI, Psoriasis Area and Severity Index; SD, standard deviation; TIL, tildrakizumab. • The efficacy analysis was concluded at week 208 for reSURFACE 1 (extension week 144; 2210.8 total patient years) and week 196 for reSURFACE 2 (2768.3 total patient years) Efficacy Figure 2. reSURFACE 1 week 64 results of PASI 75/90/100 responses for A) tildrakizumab 100 mg, B) tildrakizumab 200 mg, and C) PGA response; and reSURFACE 2 week 52 results of PASI 75/90/100 responses for D) tildrakizumab 100 mg, E) tildrakizumab 200 mg, and F) PGA response A) B) C) D) E) F) PASI, Psoriasis Area and Severity Index; PGA, Physician’s Global Assessment; TIL, tildrakizumab. • The proportion of patients achieving PASI 75/90/100 responses and PGA responses (“clear” or “minimal” with a >2-grade reduction from baseline) during the base study period of 64 weeks (reSURFACE 1) or 52 weeks (reSURFACE 2) are shown in Figure 2 Figure 3. PASI 75/90/100 responses during the extension study period by tildrakizumab dose in A) reSURFACE 1, and B) reSURFACE 2 A) B) FAS population; missing data at a given visit were not imputed. n = number of patients with data at each visit. FAS, full analysis set; PASI, Psoriasis Area and Severity Index; TIL, tildrakizumab. Figure 4. PGA responses of ‘clear’ or ‘minimal’ with a grade ≥2 reduction from baseline during extension study period by dose in A) reSURFACE 1 and B) reSURFACE 2 A) B) FAS population; missing data at a given visit were not imputed. n = number of patients with data at each visit. FAS, Full Analysis Set; PGA, Physician’s Global Assessment; TIL, tildrakizumab. • The proportions of patients who achieved a PGA response during the extension study period in reSURFACE 1 and reSURFACE 2 are presented in Figure 4 INTRODUCTION • Tildrakizumab is a high-affinity, humanized, immunoglobin G1κ, anti–interleukin-23p19 monoclonal antibody approved for the treatment of moderate to severe plaque psoriasis • Two large, phase 3, randomized, controlled trials (reSURFACE 1, NCT01722331; and reSURFACE 2, NCT01729754) of tildrakizumab were conducted in patients with moderate to severe chronic plaque psoriasis1 — Tildrakizumab significantly improved psoriasis response rates vs placebo measured with the Psoriasis Area and Severity Index (PASI 75, PASI 90, and PASI 100) and Physician’s Global Assessment (PGA) score, by week 12 (primary endpoint) — Tildrakizumab was well tolerated with low frequencies of serious adverse events (AEs) and discontinuations due to AEs2 OBJECTIVES • To evaluate the 4-year efficacy data for tildrakizumab in the ongoing long-term extension period of the phase 3 reSURFACE 1 and reSURFACE 2 studies • To evaluate the 4-year safety data for the base and extension periods of reSURFACE 1 and reSURFACE 2 METHODS Base study • Participants ≥18 years of age with moderate to severe chronic plaque psoriasis (body surface area involvement ≥10%, PGA score ≥3, and PASI score ≥12) were eligible • Part 1 (weeks 1–12). Patients were randomized (1:2:2) to blinded subcutaneous placebo or tildrakizumab 100 or 200 mg at weeks 0 and 4. reSURFACE 2 also contained an etanercept arm (50 mg twice a week) • Part 2 (weeks 12–28). Patients previously receiving placebo were rerandomized to tildrakizumab 100 or 200 mg at weeks 12 and 16 and every 12 weeks (Q12W) thereafter. Patients continuing tildrakizumab from Part 1 received a placebo injection at week 12 to maintain the blind and a dose of tildrakizumab at weeks 16 and 28. Patients previously receiving etanercept 50 mg twice a week in reSURFACE 2 continued etanercept once a week. At week 28, tildrakizumab nonresponders (PASI <50) and etanercept responders discontinued • Part 3 (weeks 28–64/52). Tildrakizumab responders (PASI ≥75) were rerandomized to receive placebo every 2 weeks (reSURFACE 1) or tildrakizumab 100 or 200 mg Q12W (reSURFACE 1 and 2). Responders who were rerandomized to placebo were retreated with the same tildrakizumab dose upon relapse (defined as reduction in maximum PASI response by 50%). In reSURFACE 2, etanercept partial responders (PASI ≥50 and PASI <75) or nonresponders transitioned to tildrakizumab 200 mg • reSURFACE 1 base study was 64 weeks; reSURFACE 2 base study was 52 weeks Extension study • Patients who completed the base study with PASI ≥50 and received tildrakizumab within 12 weeks of base study end could enter a long-term, open-label extension study (up to 192 weeks) • In the extension study (reSURFACE 1: weeks 64–256; reSURFACE 2: weeks 52–240), patients received the same dose of tildrakizumab as at completion of base study Efficacy and safety • Efficacy was evaluated using PASI and PGA response for all patients who received ≥1 dose during the extension study (Full Analysis Set [FAS] population) with no imputation of missing data (up to 4 years) • Safety: AEs were evaluated for all patients who received ≥1 dose during the base or extension study (up to 5 years) — Cumulative and yearly AE incidence rates calculated using base and extension study data — Discontinuation rates analyzed for FAS population Efficacy and safety of long-term tildrakizumab for plaque psoriasis: 4-year results from reSURFACE 1 and reSURFACE 2 Richard G Langley,1 Jeffrey Crowley,2 Melinda Gooderham,3 Kim A Papp,4 Neil J Korman,5 Lynda Spelman,6 Atsuyuki Igarashi,7 Mamitaro Ohtsuki,8 Aditya K Gupta,9 Paul Yamauchi,10 Jeffrey Parno,11 Alan M Mendelsohn,11 Stephen J Rozzo,11 Kimberly Eads,12 Scott Guenthner,12 M Alan Menter13 1Division of Dermatology, Department of Medicine, Dalhousie University, Halifax, NS, Canada; 2Bakersfield Dermatology & Skin Cancer Medical Group, Bakersfield, CA, USA; 3Probity Medical Research, and SKiN Centre for Dermatology, Peterborough, ON, Canada; and Queen’s University, Kingston, ON, Canada; 4K. Papp Clinical Research and Probity Medical Research, Waterloo, ON, Canada; 5Case Western Reserve University and University Hospital Cleveland Center, Cleveland, OH, USA; 6Veracity Clinical Research, Woolloongabba, Brisbane, Queensland, Australia; and Probity Medical Research, Brisbane, Australia; 7Department of Dermatology, NTT Medical Center Tokyo, Tokyo, Japan; 8Department of Dermatology, Jichi Medical University Hospital, Tochigi-ken, Japan; 9Division of Dermatology, Department of Medicine, University of Toronto School of Medicine, Toronto, Canada; and Mediprobe Research Inc., London, Canada; 10David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA; 11Sun Pharmaceutical Industries, Inc., Princeton, NJ, USA; 12The Indiana Clinical Trials Center, Plainfield, IN, USA; 13Division of Dermatology, Baylor Scott & White, and Texas A&M College of Medicine, Dallas, TX, USA Safety • Of the 506 patients who entered the extension period in reSURFACE 1, a total of 113 (22%) discontinued. In reSURFACE 2, a total of 153 (20.9%) of 731 patients discontinued — Most common causes of discontinuation were patient withdrawal (reSURFACE 1: 8%; reSURFACE 2: 7.5%), AEs (reSURFACE 1: 5%; reSURFACE 2: 3.0%), and loss to follow-up (reSURFACE 1: 4%; reSURFACE 2: 2.9%) • The cumulative numbers of patients who reported prespecified AEs after up to 5 years of tildrakizumab treatment are shown in Table 2 • In reSURFACE 1, there were 2 deaths among patients who proceeded from the base study to the long-term extension: 1 patient receiving tildrakizumab 100 mg (metastatic carcinoma of the bladder with intracranial hemorrhage) and 1 patient receiving tildrakizumab 200 mg (suicide) • In reSURFACE 2, there were 4 deaths among patients who proceeded into the extension: 3 patients receiving tildrakizumab 100 mg and 1 patient receiving tildrakizumab 200 mg Table 2. Cumulative number of patients with AEs of interest after up to 5 years of treatment AEs, na (Exposure-adjusted rate)b reSURFACE 1 reSURFACE 2 TIL 100 mg (n = 383; 1410.4 PY) TIL 200 mg (n = 399; 1606.5 PY) TIL 100 mg (n = 410; 1513.3 PY) TIL 200 mg (n = 380; 1404.7 PY) ETNc (n = 313; 153.4 PY) Severe infections 13 (0.9) 17 (1.1) 17 (1.6) 14 (1.0) 3 (2.0) Malignancies 18 (1.3) 11 (0.7) 10 (0.9) 12 (0.9) 4 (2.6) Nonmelanoma skin cancer 6 (0.4) 5 (0.3) 3 (0.3) 5 (0.4) 2 (1.3) Melanoma skin cancer 1 (0.1) 1 (0.1) 1 (0.1) 1 (0.1) 0 Confirmed extended MACE 7 (0.5) 9 (0.6) 7 (0.7) 10 (0.7) 1 (0.7) Drug-related hypersensitivity reactions 2 (0.1) 1 (0.1) 2 (0.2) 3 (0.2) 0 Death 1 (0.1) 2 (0.1) 6 (0.6) 1 (0.1) 0 aIncludes patients who received TIL 100 or 200 mg at any time during the study. bNumbers in parentheses represent the number of patients with the event per 100 PY of exposure unless otherwise noted. cEtanercept exposure only occurred during parts 1 and 2, there was no exposure after week 28. AE, adverse event; ETN, etanercept; MACE, major adverse cardiovascular event; PY, patient-year; TIL, tildrakizumab. CONCLUSIONS • Over 4 years of treatment with tildrakizumab, PASI and PGA response rates were high and durable for the tildrakizumab 100 and 200 mg doses in both reSURFACE 1 and reSURFACE 2 • Through up to 5 years of follow-up, both tildrakizumab doses were well tolerated with low rates of AEs of interest reported with long-term treatment in both reSURFACE 1 and reSURFACE 2. AE rates were comparable relative to etanercept-treated patients in reSURFACE 2 REFERENCES 1) Reich K, et al. Lancet. 2017;390:276–88; 2) Blauvelt A, et al. Br J Dermatol. 2018;179:615–22. ACKNOWLEDGMENTS We thank the patients for their participation. The study was funded by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA. Analyses were funded by Sun Pharmaceutical Industries, Inc., Princeton, NJ, USA. Medical writing support was provided by Kathleen Pieper, PhD, of AlphaBioCom, LLC, and funded by Sun Pharmaceutical Industries, Inc. DISCLOSURES RGL has served as principal investigator for and is on the scientific advisory board or served as a speaker for AbbVie; Amgen; Boehringer Ingelheim; Celgene; Eli Lilly and Co.; Janssen; LEO Pharma; Merck & Co; Novartis; Pfizer; and Sun Pharmaceutical Industries, Inc. JC has received research/grant support from AbbVie; Amgen; Boehringer Ingelheim; Eli Lilly and Co.; Janssen; MC2 Therapeutics; Merck & Co.; Novartis; Pfizer; Regeneron; Sandoz; Sanofi; Sun Pharmaceutical Industries, Inc.; UCB; and Verrica Pharmaceuticals; has served as consultant for AbbVie; Amgen; Celgene; Dermira; Eli Lilly and Co.; Novartis; Sun Pharmaceutical Industries, Inc.; and UCB; and has worked on speakers bureau for AbbVie, Janssen, Eli Lilly and Co., Novartis, Regeneron, Sanofi, and UCB. MG has been an investigator, consultant, and/or speaker for AbbVie; Actelion Pharmaceuticals; Akros Pharma; Amgen; Arcutis Pharmaceuticals; Boehringer Ingelheim; Bristol-Myers Squibb; Celgene; Dermira; Eli Lilly and Co.; Galderma; Glenmark; GlaxoSmithKline; Janssen; LEO Pharma; MedImmune; Merck & Co; Novartis; Pfizer; Regeneron; Roche; Sanofi Genzyme; Sun Pharmaceutical Industries, Inc.; UCB; and Valeant Pharmaceuticals; and has been on an advisory board for AbbVie; Amgen; Boehringer Ingelheim; Celgene; Eli Lilly and Co.; Galderma; Janssen; LEO Pharma; Novartis; Pfizer; Regeneron; Sanofi Genzyme; Sun Pharmaceutical Industries, Inc.; and Valeant Pharmaceuticals. KAP has served as consultant and/or investigator and/or speaker for AbbVie, Akros, Allergan, Amgen, Anacor, Arcutis, Astellas, AstraZeneca, Baxalta, Baxter, Boehringer Ingelheim, Bristol-Myers Squibb, CanFite, Celgene, Coherus, Dermira, Dow Pharma, Eli Lilly and Co., Forward Pharma, Galderma, Genentech, Gilead Sciences, GlaxoSmithKline, InflaRx GmbH, Janssen, Kyowa Hakko Kirin, LEO Pharma, MedImmune, Meiji Seika Pharma, Merck Sharp & Dohme, Merck-Serono, Mitsubishi Pharma, Moberg Pharma, Novartis, Pfizer, PRCL Research, Regeneron, Roche, Sanofi-Aventis/Genzyme, Takeda, UCB, and Valeant/Bausch Health; on a steering committee and/or advisory board for AbbVie, Amgen, Astellas, Baxter, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Dow Pharma, Eli Lilly and Co., Galderma, Janssen, Kyowa Hakko Kirin, Merck Sharp & Dohme, Merck-Serono, Novartis, Pfizer, Regeneron, Sanofi-Aventis/Genzyme, UCB, and Valeant/Bausch Health; and as scientific officer for Akros, Anacor, and Kyowa Hakko Kirin. NJK has received grants/research funding via their institution from Eli Lilly and Co., LEO Pharma, Merck Sharp & Dohme, Pfizer, Prothena, Trevi, and UCB Pharma; honoraria as an advisory board member for AbbVie; Celgene; Eli Lilly and Co.; Genentech; GlaxoSmithKline; Immune Pharm; Janssen; Novartis; Regeneron; Sun Pharmaceutical Industries, Inc.; and Valeant; and honoraria as a speaker for AbbVie, Eli Lilly and Co., Janssen, and Novartis. LS has served on advisory boards for AbbVie, Eli Lilly and Co., Galderma, and Novartis; has served as an investigator for AbbVie; Amgen; Anacor; Ascend Biopharmaceuticals; Astellas; Australian Wool Innovation Limited; Blaze Bioscience; BMS; Celgene; Dermira; Eli Lilly and Co.; Galderma; Genentech; GlaxoSmithKline; Janssen; Kythera; LEO Pharma; Merck; Novartis; Phosphagenics; Regeneron; Sun Pharmaceutical Industries, Inc.; and Trius; and has received sponsored travel from Abbott Labs, Janssen-Cilag, and Novartis. AI has received honoraria as a member of an advisory board for AbbVie, Celgene K.K., Eli Lilly Japan K.K., Janssen Pharmaceutical K.K., Maruho Co Ltd., Novartis Pharma K.K., and Sun Pharma Japan Ltd. MO has received honoraria as a member of an advisory board for AbbVie, Boehringer Ingelheim Co Ltd, Bristol-Myers Squibb Company, Celgene K.K., Eisai Co Ltd, Eli Lilly Japan K.K., Janssen Pharmaceutical K.K., Kyowa Hakko Kirin Co Ltd, LEO Pharma K.K., Maruho Co Ltd., Mitsubishi Tanabe Pharma Co, Novartis Pharma K.K., Pfizer Japan, and Sun Pharma Japan Ltd. AKG has been an investigator for Sun Pharmaceutical Industries, Inc. PY has received honoraria as a consultant from AbbVie; Amgen; Celgene; Janssen; LEO Pharma; Menlo Therapeutics; Novartis; Ortho Dermatologics; Pfizer; Regeneron; and Sun Pharmaceutical Industries, Inc.; research grants from Amgen, Celgene, Dermira, Galderma, Janssen, LEO Pharma, Lilly ICOS, MedImmune, Menlo Therapeutics, Novartis, Ortho Dermatologics, Pfizer, Regeneron, and Sandoz; has served on advisory boards for Amgen, Dermira, and Lilly ICOS; and has served as a speaker for AbbVie; Amgen; Celgene; Janssen; LEO Pharma; Lilly ICOS; Novartis; Ortho Dermatologics; Pfizer; Regeneron; Sanofi/Regeneron; and Sun Pharmaceutical Industries, Inc. AMM is an employee of Sun Pharmaceutical Industries, Inc.; and has individual shares in Johnson and Johnson, and as part of a retirement account/mutual funds. SJR is an employee of Sun Pharmaceutical Industries, Inc. KE has nothing to disclose. SG has received grants and/or honoraria as an investigator and/or speaker from AbbVie; Amgen; Dermira; Eli Lilly and Co.; Encore Dermatology; Genentech; Janssen; LEO Pharma; Pfizer; Sun Pharmaceutical Industries, Inc.; UCB; and Vanda. MAM has received grants and/or honoraria as a consultant, investigator, and/or speaker for AbbVie, Abbott Labs, Amgen, Anacor, Boehringer Ingelheim, Celgene, Eli Lilly and Co., Janssen, LEO Pharma, Merck & Co, Novartis, Sienna, and UCB; and has been on an advisory board for AbbVie, Amgen, Boehringer Ingelheim, Eli Lilly and Co., Janssen, LEO Pharma, and Sienna. Randomized Base study Extension study Completed week 64/52 Entered extension Completed extension week 208/196 N = 772 N = 1090 n = 341 n = 362 n = 267 n = 349 n = 226 n = 28 n = 239 n = 382 n = 178 n = 29 n = 297 n = 394 reSURFACE 1 reSURFACE 2 TIL 100 mg TIL 200 mg Presented at Fall Clinical Dermatology Conference for PAs & NPs 2020, April 3–5, Orlando, FL, USA PASI 75 PASI 90 PASI 100 0 20 40 60 80 100 reSURFACE 2 TIL 100 mg P at ie nt s , % PASI 75 PASI 90 PASI 100 0 20 40 60 80 100 reSURFACE 2 TIL 200 mg P at ie nt s , % TIL 100 mg TIL 200 mg 0 20 40 60 80 100 reSURFACE 2 PGA P at ie nt s , % TIL 100 mg TIL 200 mg 0 20 40 60 80 100 reSURFACE 1 PGA P at ie nt s , % PASI 75 PASI 90 PASI 100 0 20 40 60 80 100 reSURFACE 1 TIL 200 mg P at ie nt s , % PASI 75 PASI 90 PASI 100 0 20 40 60 80 100 reSURFACE 1 TIL 100 mg P at ie nt s , % PASI 75 PASI 90 PASI 100 0 20 40 60 80 100 reSURFACE 2 TIL 100 mg P at ie nt s , % PASI 75 PASI 90 PASI 100 0 20 40 60 80 100 reSURFACE 2 TIL 200 mg P at ie nt s , % TIL 100 mg TIL 200 mg 0 20 40 60 80 100 reSURFACE 2 PGA P at ie nt s , % TIL 100 mg TIL 200 mg 0 20 40 60 80 100 reSURFACE 1 PGA P at ie nt s , % PASI 75 PASI 90 PASI 100 0 20 40 60 80 100 reSURFACE 1 TIL 200 mg P at ie nt s , % PASI 75 PASI 90 PASI 100 0 20 40 60 80 100 reSURFACE 1 TIL 100 mg P at ie nt s , % PASI 75 PASI 90 PASI 100 0 20 40 60 80 100 reSURFACE 2 TIL 100 mg P at ie nt s , % PASI 75 PASI 90 PASI 100 0 20 40 60 80 100 reSURFACE 2 TIL 200 mg P at ie nt s , % TIL 100 mg TIL 200 mg 0 20 40 60 80 100 reSURFACE 2 PGA P at ie nt s , % TIL 100 mg TIL 200 mg 0 20 40 60 80 100 reSURFACE 1 PGA P at ie nt s , % PASI 75 PASI 90 PASI 100 0 20 40 60 80 100 reSURFACE 1 TIL 200 mg P at ie nt s , % PASI 75 PASI 90 PASI 100 0 20 40 60 80 100 reSURFACE 1 TIL 100 mg P at ie nt s , % 0 20 40 60 80 100 reSURFACE 1 Extension week P at ie nt s, % 0 12 24 36 48 60 72 84 120 14496 0 20 40 60 80 100 reSURFACE 2 Week P at ie nt s, % 52 60 64 76 88 100 112 124 136 148 172 196 PASI 75 (TIL 100 mg) PASI 90 (TIL 100 mg) PASI 100 (TIL 100 mg) PASI 75 (TIL 200 mg) PASI 90 (TIL 200 mg) PASI 100 (TIL 200 mg) TIL 100 mg n = 233 229 228 221 217 211 205 205 200 187 178 TIL 200 mg n = 264 263 262 250 256 253 252 248 241 235 226 TIL 100 mg n = 376 379 373 372 365 356 350 344 332 322 126 21 TIL 200 mg n = 344 348 345 340 338 333 324 313 307 298 136 19 A) B) 0 20 40 60 80 100 reSURFACE 1 Extension week P at ie nt s, % 0 12 24 36 48 60 72 84 120 14496 0 20 40 60 80 100 reSURFACE 2 Week P at ie nt s, % 52 60 64 76 88 100 112 124 136 148 172 196 PASI 75 (TIL 100 mg) PASI 90 (TIL 100 mg) PASI 100 (TIL 100 mg) PASI 75 (TIL 200 mg) PASI 90 (TIL 200 mg) PASI 100 (TIL 200 mg) TIL 100 mg n = 233 229 228 221 217 211 205 205 200 187 178 TIL 200 mg n = 264 263 262 250 256 253 252 248 241 235 226 TIL 100 mg n = 376 379 373 372 365 356 350 344 332 322 126 21 TIL 200 mg n = 344 348 345 340 338 333 324 313 307 298 136 19 A) B) 0 20 40 60 80 100 reSURFACE 1 Extension week P at ie nt s, % 0 12 24 36 48 60 72 84 120 14496 0 20 40 60 80 100 reSURFACE 2 Week P at ie nt s, % 52 60 64 76 88 100 112 124 136 148 172 196 PASI 75 (TIL 100 mg) PASI 90 (TIL 100 mg) PASI 100 (TIL 100 mg) PASI 75 (TIL 200 mg) PASI 90 (TIL 200 mg) PASI 100 (TIL 200 mg) TIL 100 mg n = 233 229 228 221 217 211 205 205 200 187 178 TIL 200 mg n = 264 263 262 250 256 253 252 248 241 235 226 TIL 100 mg n = 376 379 373 372 365 356 350 344 332 322 126 21 TIL 200 mg n = 344 348 345 340 338 333 324 313 307 298 136 19 A) B) 0 20 40 60 80 100 reSURFACE 1 Extension week P at ie nt s, % 0 12 24 36 48 60 72 84 120 14496 0 20 40 60 80 100 reSURFACE 2 Week P at ie nt s, % 52 60 64 76 88 100 112 124 136 148 172 196 PASI 75 (TIL 100 mg) PASI 90 (TIL 100 mg) PASI 100 (TIL 100 mg) PASI 75 (TIL 200 mg) PASI 90 (TIL 200 mg) PASI 100 (TIL 200 mg) TIL 100 mg n = 233 229 228 221 217 211 205 205 200 187 178 TIL 200 mg n = 264 263 262 250 256 253 252 248 241 235 226 TIL 100 mg n = 376 379 373 372 365 356 350 344 332 322 126 21 TIL 200 mg n = 344 348 345 340 338 333 324 313 307 298 136 19 A) B) 0 20 40 60 80 100 reSURFACE 1 Extension week P at ie nt s, % 0 12 24 36 48 60 72 84 120 14496 0 20 40 60 80 100 reSURFACE 2 Week P at ie nt s, % 52 60 64 76 88 100 112 124 136 148 172 196 PASI 75 (TIL 100 mg) PASI 90 (TIL 100 mg) PASI 100 (TIL 100 mg) PASI 75 (TIL 200 mg) PASI 90 (TIL 200 mg) PASI 100 (TIL 200 mg) TIL 100 mg n = 233 229 228 221 217 211 205 205 200 187 178 TIL 200 mg n = 264 263 262 250 256 253 252 248 241 235 226 TIL 100 mg n = 376 379 373 372 365 356 350 344 332 322 126 21 TIL 200 mg n = 344 348 345 340 338 333 324 313 307 298 136 19 A) B) 0 20 40 60 80 100 reSURFACE 1 Extension week P at ie nt s, % 0 12 24 36 48 60 72 84 120 14496 0 20 40 60 80 100 reSURFACE 2 Week P at ie nt s, % 52 60 64 76 88 100 112 124 136 148 172 196 PASI 75 (TIL 100 mg) PASI 90 (TIL 100 mg) PASI 100 (TIL 100 mg) PASI 75 (TIL 200 mg) PASI 90 (TIL 200 mg) PASI 100 (TIL 200 mg) TIL 100 mg n = 233 229 228 221 217 211 205 205 200 187 178 TIL 200 mg n = 264 263 262 250 256 253 252 248 241 235 226 TIL 100 mg n = 376 379 373 372 365 356 350 344 332 322 126 21 TIL 200 mg n = 344 348 345 340 338 333 324 313 307 298 136 19 A) B) 0 20 40 60 80 100 reSURFACE 1 Extension week P at ie nt s, % 0 12 24 36 48 60 72 84 120 14496 0 20 40 60 80 100 reSURFACE 2 Week P at ie nt s, % 52 60 64 76 88 100 112 124 136 148 172 196 PASI 75 (TIL 100 mg) PASI 90 (TIL 100 mg) PASI 100 (TIL 100 mg) PASI 75 (TIL 200 mg) PASI 90 (TIL 200 mg) PASI 100 (TIL 200 mg) TIL 100 mg n = 233 229 228 221 217 211 205 205 200 187 178 TIL 200 mg n = 264 263 262 250 256 253 252 248 241 235 226 TIL 100 mg n = 376 379 373 372 365 356 350 344 332 322 126 21 TIL 200 mg n = 344 348 345 340 338 333 324 313 307 298 136 19 A) B) 0 20 40 60 80 100 reSURFACE 1 Extension week P at ie nt s, % TIL 100 mg TIL 200 mg 0 12 24 36 48 60 72 84 120 14496 0 20 40 60 80 100 reSURFACE 2 Week P at ie nt s, % TIL 100 mg TIL 200 mg 52 60 64 76 88 100 112 124 136 148 172 196 TIL 100 mg n = 232 227 225 221 217 211 205 205 200 187 178 TIL 200 mg n = 262 263 259 245 254 250 250 247 240 235 226 TIL 100 mg n = 375 375 371 370 363 352 347 342 330 321 125 21 TIL 200 mg n = 341 345 342 337 335 330 321 310 304 295 135 19 A) B) 0 20 40 60 80 100 reSURFACE 1 Extension week P at ie nt s, % TIL 100 mg TIL 200 mg 0 12 24 36 48 60 72 84 120 14496 0 20 40 60 80 100 reSURFACE 2 Week P at ie nt s, % TIL 100 mg TIL 200 mg 52 60 64 76 88 100 112 124 136 148 172 196 TIL 100 mg n = 232 227 225 221 217 211 205 205 200 187 178 TIL 200 mg n = 262 263 259 245 254 250 250 247 240 235 226 TIL 100 mg n = 375 375 371 370 363 352 347 342 330 321 125 21 TIL 200 mg n = 341 345 342 337 335 330 321 310 304 295 135 19 A) B) 0 20 40 60 80 100 reSURFACE 1 Extension week P at ie nt s, % 0 12 24 36 48 60 72 84 120 14496 0 20 40 60 80 100 reSURFACE 2 Week P at ie nt s, % 52 60 64 76 88 100 112 124 136 148 172 196 PASI 75 (TIL 100 mg) PASI 90 (TIL 100 mg) PASI 100 (TIL 100 mg) PASI 75 (TIL 200 mg) PASI 90 (TIL 200 mg) PASI 100 (TIL 200 mg) TIL 100 mg n = 233 229 228 221 217 211 205 205 200 187 178 TIL 200 mg n = 264 263 262 250 256 253 252 248 241 235 226 TIL 100 mg n = 376 379 373 372 365 356 350 344 332 322 126 21 TIL 200 mg n = 344 348 345 340 338 333 324 313 307 298 136 19 A) B) 0 20 40 60 80 100 reSURFACE 1 Extension week P at ie nt s, % 0 12 24 36 48 60 72 84 120 14496 0 20 40 60 80 100 reSURFACE 2 Week P at ie nt s, % 52 60 64 76 88 100 112 124 136 148 172 196 PASI 75 (TIL 100 mg) PASI 90 (TIL 100 mg) PASI 100 (TIL 100 mg) PASI 75 (TIL 200 mg) PASI 90 (TIL 200 mg) PASI 100 (TIL 200 mg) TIL 100 mg n = 233 229 228 221 217 211 205 205 200 187 178 TIL 200 mg n = 264 263 262 250 256 253 252 248 241 235 226 TIL 100 mg n = 376 379 373 372 365 356 350 344 332 322 126 21 TIL 200 mg n = 344 348 345 340 338 333 324 313 307 298 136 19 A) B)