# bib

id: cord-255357-oar2pttf
author: Kijima, Emi
title: Kawasaki Disease and Invasive Pneumococcal Infection
date: 2020-06-17
extension: .txt
mime: text/plain
words: 540
sentence: 23
flesch: 41
cache: cache/cord-255357-oar2pttf.txt
txt: txt/cord-255357-oar2pttf.txt
summary:
  Kawasaki disease associated with pneumococcal infection. SN Comprehensive Clinical Medicine Evaluation of Kawasaki disease risk scoring system in a single center experience from Japan Impact of D-dimer on the resistance to intravenous immunoglobulin therapy in Kawasaki disease GSL Circulating CD3+ HLA-DR+ extracellular vesicles are not increased in the acute phase of Kawasaki disease Soluble Sortilin in elevated in the acute phase of Kawasaki disease An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study Erythema multiforme and Kawasaki disease associated with COVID-19 infection in children Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.


id: cord-323368-cf5axwcb
author: Schena, Daniele
title: Re-reading the SARS-COV-2 Epidemic in Bergamo
date: 2020-08-11
extension: .txt
mime: text/plain
words: 732
sentence: 21
flesch: 34
cache: cache/cord-323368-cf5axwcb.txt
txt: txt/cord-323368-cf5axwcb.txt
summary:
  In recent months, several hypotheses have been offered to explain the rapid spread of the virus in Bergamo province and Lombardy, but all of them are focused on what happened in the hospitals (Codogno, Alzano Lombardo, and other emergency departments across the territory) involved in the SARS-CoV-2 epidemic. key: cord-323368-cf5axwcb authors: Schena, Daniele; Marinoni, Guido; Galassi, Luca title: Re-reading the SARS-COV-2 Epidemic in Bergamo date: 2020-08-11 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00431-9 sha: doc_id: 323368 cord_uid: cf5axwcb Bergamo province was one of the hardest hit regions by the novel SARS-CoV-2 virus.


id: cord-270645-tzctvs9q
author: Martelletti, Luigi
title: Air Pollution and the Novel Covid-19 Disease: a Putative Disease Risk Factor
date: 2020-04-15
extension: .txt
mime: text/plain
words: 947
sentence: 37
flesch: 41
cache: cache/cord-270645-tzctvs9q.txt
txt: txt/cord-270645-tzctvs9q.txt
summary:
  The assumption that air pollution conditions facilitate the spread of the virus was shown and supported by Cui et al. A recent study from the SIMA (Società Italiana di Medicina Ambientale) reported that the specificity of the high spread of the contagious virus in some areas of Northern Italy is likely to be linked to air pollution conditions.


id: cord-298980-yt52bgc7
author: Ferrara, Francesco
date: 2020-06-26
extension: .txt
mime: text/plain
words: 919
sentence: 37
flesch: 41
cache: cache/cord-298980-yt52bgc7.txt
txt: txt/cord-298980-yt52bgc7.txt
title:
  Worldwide Recommendations and Therapies for Multiple Sclerosis: Are They Safe in the COVID-19 Pandemic Period?

summary:
  All countries agree that IFN-β is the safest drug and can also protect against COVID-19 infection due to its antiviral properties. In general all recommendations consider that first-line drugs (teriflunomide and dimethylfumarate) should be continued and suspended in case of COVID-19 infection; in Germany and Canada, suspension is also recommended in case of severe lymphopenia.


id: cord-284785-mkjogy6h
author: Trevisan, Caterina
title: Labile PT-INR in a Covid-19 Patient Under Long-term Vitamin K Antagonist Therapy: a Case Report
date: 2020-08-19
extension: .txt
mime: text/plain
words: 1317
sentence: 47
flesch: 41
cache: cache/cord-284785-mkjogy6h.txt
txt: txt/cord-284785-mkjogy6h.txt
summary:
  The patient was a 93-year-old woman admitted to a post-acute care unit for COVID-19 patients in northern Italy. Special attention should therefore be paid to COVID-19 patients under anticoagulation with vitamin K antagonist and a shift to heparin treatment until illness resolution may be a safe option in these individuals.


id: cord-263763-a8wgvgz2
author: Çelik, Ersin
date: 2020-07-02
extension: .txt
mime: text/plain
words: 1540
sentence: 72
flesch: 45
cache: cache/cord-263763-a8wgvgz2.txt
txt: txt/cord-263763-a8wgvgz2.txt
title:
  Treatment Approach to Coronavirus Disease (COVID-19) Seen Early After Open Heart Surgery. Case Report

summary:
  We aimed to present our approach to high probability COVID-19 pneumonia which developed on early postoperative period in our patient after coronary artery bypass grafting (CABG) operation, which was not reported in the literature before. We should assume and keep in mind that there are also pandemic and asymptomatic carriers, especially in elderly patients who undergo open heart surgery with many additional risk factors.


id: cord-288732-k763ejqb
author: ElMajjaoui, Sanaa
title: COVID-19, Brachytherapy, and Gynecologic Cancers: a Moroccan Experience
date: 2020-07-15
extension: .txt
mime: text/plain
words: 1740
sentence: 71
flesch: 34
cache: cache/cord-288732-k763ejqb.txt
txt: txt/cord-288732-k763ejqb.txt
summary:
  COVID-19 and gynecological cancers: a Moroccan point-of-view Radiation therapy for gynecologic malignancies during the COVID-19 pandemic: international expert consensus recommendations Epidemiology and outcome of cervical cancer in national institute of Morocco FIGO IIIB squamous cell carci-noma of the cervix: an analysis of prognostic factors emphasizing the balance between external beam and intracavitary radiation therapy Brachytherapy versus radical hysterectomy after external beam chemoradiation with gemcitabine plus cisplatin: a randomized, phase III study in IB2-IIB cervical cancer patients Clinical impact of MRI assisted dose volume adaptation and dose esca-lation in brachytherapy of locally advanced cervix cancer MRI-guided adaptive radiotherapy in locally advanced cervical cancer from a Nordic perspective Image guided brachytherapy in locally advanced cervical cancer: improved pelvic control and survival in RetroEMBRACE, a multicenter cohort study Figo IIIB squamous cell carcinoma of the cervix: an analysis of prog-nostic factors emphasizing the balance between external beam and intracavitary radiation therapy Differences in outcome for cervical cancer patients treated with or without brachyther-apy Imageguided radiotherapy for cervix cancer: high-tech external beam ther-apy versus high-tech brachytherapy Image guided brachytherapy in locally advanced cervical cancer: improved pelvic control and survival in RetroEMBRACE, a multicenter cohort study Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV Recommendations from gynaecological (GYN) GEC ESTRO working grooooup (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology Computed tomography versus magnetic resonance imaging-based contouring in cervical cancer brachytherapy: results of a prospective trial and preliminary guidelines for standardized contours COVID-19 impact on timing of brachytherapy treatment and strategies for risk mitigation RTOG 0417. Brachytherapy treatment should be started on time without any delay.


id: cord-262945-zfcz0hpd
author: Chow, Lai Chee
title: Thrombosis and Bleeding as Presentation of COVID-19 Infection with Polycythemia Vera. A Case Report
date: 2020-10-04
extension: .txt
mime: text/plain
words: 2050
sentence: 107
flesch: 52
cache: cache/cord-262945-zfcz0hpd.txt
txt: txt/cord-262945-zfcz0hpd.txt
summary:
  It can also be used to monitor response to treatment of thrombosis in polycythemia vera patients in the context of COVID-19 infection. We describe a case of cerebral venous thrombosis in COVID-19 infection with underlying polycythemia vera a b Fig.


id: cord-329447-kjeqs6zh
author: Shen, Bingzheng
date: 2020-07-04
extension: .txt
mime: text/plain
words: 2074
sentence: 99
flesch: 39
cache: cache/cord-329447-kjeqs6zh.txt
txt: txt/cord-329447-kjeqs6zh.txt
title:
  Wuchang Fangcang Shelter Hospital: Practices, Experiences, and Lessons Learned in Controlling COVID-19

summary:
  key: cord-329447-kjeqs6zh authors: Shen, Bingzheng; Chen, Li; Zhang, Lu; Zhang, Mengke; Li, Jing; Wu, Jie; Chen, Kunlin; Xiong, Yuanguo; Song, Wei; Zhou, Benhong title: Wuchang Fangcang Shelter Hospital: Practices, Experiences, and Lessons Learned in Controlling COVID-19 date: 2020-07-04 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00382-1 sha: doc_id: 329447 cord_uid: kjeqs6zh In early January 2020, the outbreak of the new corona virus pneumonia (Corona Virus Disease 2019, COVID-19) occurred. A large comprehensive gymnasium was converted into Wuchang Fangcang Shelter Hospital in order to provide adequate medical beds and appropriate care for the confirmed patients with mild to moderate symptoms.


id: cord-295500-j84v1k1o
author: Conway, J.
title: Chinese and British Hospitalised Patients with COVID-19—a Comparative Case Series Analysis
date: 2020-07-18
extension: .txt
mime: text/plain
words: 2278
sentence: 92
flesch: 47
cache: cache/cord-295500-j84v1k1o.txt
txt: txt/cord-295500-j84v1k1o.txt
summary:
  In this analysis, we aimed to describe a comparative analysis between a Chinese and a British cohort to explore the differences of COVID-19 patients across Asia and Europe. In this case series, we aimed to describe a comparative analysis between a Chinese and a British cohort to explore the differences of COVID-19 patients between the two countries.


id: cord-289115-bntcn0m6
author: Thangaraju, Pugazhenthan
date: 2020-09-10
extension: .txt
mime: text/plain
words: 2138
sentence: 88
flesch: 44
cache: cache/cord-289115-bntcn0m6.txt
txt: txt/cord-289115-bntcn0m6.txt
title:
  Role of Dupilumab in Approved Indications of COVID-19 Patient: an Efficacy-Based Nonsystematic Critical Analysis

summary:
  There are isolated case reports and series that document a milder course of COVID-19 infection in patients who have already been on dupilumab therapy for treatment of conditions such as atopic dermatitis and chronic rhino-sinusitis with nasal polyp. The International League of Dermatological Society (ILDS) guidance in contrast asserts that current evidence does not justify the discontinuation of dupilumab therapy for AD in healthy subjects [8] .


id: cord-265293-l9omunq4
author: Schönegger, Carmen Maria
date: 2020-10-24
extension: .txt
mime: text/plain
words: 2119
sentence: 101
flesch: 48
cache: cache/cord-265293-l9omunq4.txt
txt: txt/cord-265293-l9omunq4.txt
title:
  Smell and Taste Disorders in COVID-19 Patients: Objective Testing and Magnetic Resonance Imaging in Five Cases

summary:
  Nevertheless, controlled studies indicate that anosmia is more common in COVID-19 patients than in patients suffering from other viral infections or controls [17] . Hypothesis of neurotropism of SARS-CoV-2 is based on COVID-19 patients with neurological manifestations.


id: cord-352642-u513wnu1
author: Patrocínio de Jesus, Rita
date: 2020-10-02
extension: .txt
mime: text/plain
words: 2218
sentence: 77
flesch: 37
cache: cache/cord-352642-u513wnu1.txt
txt: txt/cord-352642-u513wnu1.txt
title:
  Reactivation of SARS-CoV-2 after Asymptomatic Infection while on High-Dose Corticosteroids. Case Report

summary:
  A recent study which compared IgA, IgM, and IgG responses in COVID-19 patients [10] has showed that medium seroconversion time was 4 to 6 days for IgA and IgM and 5 to 10 days for IgG. Notably, this patient's IgA levels were not available on the first serology sample collected on the seventh day after symptoms onset, which is of importance since IgA detection seems to show the highest sensitivity at the beginning of disease (highest positive diagnostic rate at 4 to 10 days after symptom onset) Fluctuating shedding of SARS-CoV-2 has been described on COVID-19 patients [12, 13] and not only has asymptomatic infection been associated with a higher likelihood of SARS-CoV-2 RNA clearance within the first week of diagnosis when compared with symptomatic infection [14] but there have also been reports of COVID-19 reactivation


id: cord-338544-eph89g47
author: Spuntarelli, Valerio
title: COVID-19: is it just a lung disease? A case-based review
date: 2020-07-28
extension: .txt
mime: text/plain
words: 2286
sentence: 117
flesch: 40
cache: cache/cord-338544-eph89g47.txt
txt: txt/cord-338544-eph89g47.txt
summary:
  Int Forum Allergy Rhinol Guillain Barre syndrome associated with COVID-19 infection: a case report Guillain-Barré syndrome following COVID-19: new infection, old complication? COVID-19-associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features Central nervous system manifestations of COVID-19: a systematic review New onset acute symptomatic seizure and risk factors in coronavirus disease 2019: a retrospective multicenter study Orchitis: a complication of severe acute respiratory syndrome (SARS)1 Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Possible involvement of infection with human coronavirus 229E, but not NL63, in Kawasaki disease COVID-19 and the liver: little cause for concern Potential pathogenesis of ageusia and anosmia in COVID-19 patients.


id: cord-351531-wo1ggmmn
author: Giustiniano, Enrico
title: Trans-thoracic Echocardiography in Prone Positioning COVID-19 Patients: a Small Case Series
date: 2020-09-15
extension: .txt
mime: text/plain
words: 2570
sentence: 103
flesch: 40
cache: cache/cord-351531-wo1ggmmn.txt
txt: txt/cord-351531-wo1ggmmn.txt
summary:
  The main result of our retrospective analysis is that TTE can be performed in patients in prone positioning and is reliable and repeatable; the single apical-four-chamber view provides sufficient data to evaluate the cardiac performance in case of scarce availability of hemodynamic monitoring devices, like in a pandemic setting. Among survivors, the mean The main results of our retrospective analysis on a small cases series consisted of few main points: (1) TTE can be performed in patients in prone positioning and is reliable in comparison with the supine TTE and repeatable, meaning that it may be used also to monitor the cardiac function every time it is needed, in a standardized way (i.e., without any minimal changing of the patient position, during both supine and prone positioning); the single apical-four-chamber view provides sufficient data to evaluate the cardiac performance in case of scarce availability of hemodynamic monitoring devices, like in a pandemic setting; (2) according to recent scientific reports, prone positioning in patients suffering from ARDS due to COVID-19 pneumonia is not always effective.


id: cord-255047-0kr4y753
author: Goletti, Orlando
date: 2020-08-17
extension: .txt
mime: text/plain
words: 2469
sentence: 91
flesch: 40
cache: cache/cord-255047-0kr4y753.txt
txt: txt/cord-255047-0kr4y753.txt
title:
  Factors Affecting Mortality in 1022 COVID-19 Patients Referred to an Emergency Department in Bergamo during the Peak of the Pandemic

summary:
  Patients who were treated in AAUL-2 had a fatal event within 48 h (median 1 day, range 0-2), while patients admitted in the COVID department or in ICU died within 24 days (median 6 days, range 0-24). Patients deceased in AAUL-2 resulted in the worst conditions in comparison with patients who died in the ICU and in COVID-19 department, and their prognostic parameters reflect the situation.


id: cord-292997-xbomgwzx
author: Singh, Sandeep
title: Takotsubo Syndrome in Patients with COVID-19: a Systematic Review of Published Cases
date: 2020-10-06
extension: .txt
mime: text/plain
words: 2431
sentence: 101
flesch: 45
cache: cache/cord-292997-xbomgwzx.txt
txt: txt/cord-292997-xbomgwzx.txt
summary:
  However, limited data on TTS in COVID-19 patients with only a handful of case reports promoted us to systematically review the published cases and pertinent outcomes. We searched PubMed/Medline, Web of Science, SCOPUS, and Google Scholar until June 15, 2020 for case reports and case series using these keywords: COVID-19, SARS-CoV-2, takotsubo syndrome/takotsubo cardiomyopathy, stressinduced cardiomyopathy, and broken heart syndrome.


id: cord-318542-785hnh19
author: Leeson, Cale E.
title: Systematic Review: Safety of Intravesical Therapy for Bladder Cancer in the Era of COVID-19
date: 2020-08-18
extension: .txt
mime: text/plain
words: 2672
sentence: 95
flesch: 34
cache: cache/cord-318542-785hnh19.txt
txt: txt/cord-318542-785hnh19.txt
summary:
  [9] Intravesical BCG treatment in immunocompromised patients remains a relative contraindication in some guidelines 7 , while its role in the treatment of acute immunological disorders remains uncertain. We aim to review and summarize what is known about COVID-19 and the current implications of intravesical BCG with regard to the disease.


id: cord-336790-29im4gxw
author: Violetis, Odyssefs A.
date: 2020-06-29
extension: .txt
mime: text/plain
words: 2667
sentence: 104
flesch: 38
cache: cache/cord-336790-29im4gxw.txt
txt: txt/cord-336790-29im4gxw.txt
title:
  COVID-19 Infection and Haematological Involvement: a Review of Epidemiology, Pathophysiology and Prognosis of Full Blood Count Findings

summary:
  A novel coronavirus from patients with pneumonia in China Identification of a novel coronavirus in patients with severe acute respiratory syndrome Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome Cardiovascular disease and COVID-19 Neurologic manifestations of hospitalized patients with coronavirus disease COVID-19 and its implications for thrombosis and anticoagulation COVID-19 and thrombotic or thromboembolic disease : implications for prevention, antithrombotic therapy and follow-up Covid-19 and the digestive system COVID-19: consider cytokine storm and immunosuppression Clinical characteristics of coronavirus disease 2019 in China Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Clinical features of patients infected with 2019 novel coronavirus in Wuhan Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis Complex immune dysregulation in COVID-19 patients with severe respiratory failure Dysregulation of immune response in patients with COVID-19 in Wuhan, China The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks Eosinophil count in severe coronavirus disease 2019 Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa Hematological findings and complications of COVID-19 Hematologic parameters in patients with COVID-19 infection Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington state Suppressed T cell-mediated immunity in patients with COVID-19: a clinical retrospective study in Wuhan Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis Mechanism of thrombocytopenia in COVID-19 patients Platelet biogenesis in the lung circulation Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia A meta-analysis conducted by Lippi G. et al. included 9 studies with a total of 1779 COVID-19 patients examining the association between thrombocytopenia and severity of the disease.


id: cord-011297-4um9w2dx
author: Brunker, Lucille
title: New-Onset Refractory Status Epilepticus with Underlying Autoimmune Etiology: a Case Report
date: 2019-11-28
extension: .txt
mime: text/plain
words: 2963
sentence: 123
flesch: 34
cache: cache/cord-011297-4um9w2dx.txt
txt: txt/cord-011297-4um9w2dx.txt
summary:
  For neurologic protection, the patient was initiated on burst suppression therapy, with a target of 1-2 epileptic bursts per screen on EEG monitor. Despite treatment with multiple anti-epileptic drugs in addition to IV anesthetics, burst suppression was initially unsustainable and the patient remained in super-refractory status epilepticus.


id: cord-310084-taaz6mhs
author: Fatehi, Poya
title: Acute Ischemic and Hemorrhagic Stroke and COVID-19: Case Series
date: 2020-10-01
extension: .txt
mime: text/plain
words: 3012
sentence: 138
flesch: 49
cache: cache/cord-310084-taaz6mhs.txt
txt: txt/cord-310084-taaz6mhs.txt
summary:
  Evidence from previous studies have indicated that patients with severe coronavirus disease might experience respiratory failure with an urgent need for artificial respiration, and other organ dysfunction [7] . His first symptoms were cough and shortness of breath 1 week before hospitalization when he was referred to an allergy specialist and was diagnosed with coronavirus disease after testing for RT-PCR and a confirmative CT scan of the chest.


id: cord-035099-8yk0dzxf
author: Brika, Marine
title: Geriatric Rehabilitation and COVID-19: a Case Report
date: 2020-11-09
extension: .txt
mime: text/plain
words: 3033
sentence: 149
flesch: 42
cache: cache/cord-035099-8yk0dzxf.txt
txt: txt/cord-035099-8yk0dzxf.txt
summary:
  Mr. P is a 93-year-old frail patient, hospitalized after a COVID-19 infection. The care plan was developed accordingly, and four assessments were done in the same manner until Mr. P returned home.


id: cord-284734-qioy7eso
author: Pourahmad, Ramtin
title: Efficacy of Plasmapheresis and Immunoglobulin Replacement Therapy (IVIG) on Patients with COVID-19
date: 2020-07-31
extension: .txt
mime: text/plain
words: 3077
sentence: 129
flesch: 40
cache: cache/cord-284734-qioy7eso.txt
txt: txt/cord-284734-qioy7eso.txt
summary:
  4433 cases Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital Treatment with convalescent plasma for COVID-19 patients in Wuhan The convalescent sera option for containing COVID-19 Molecular mechanism for antibody-dependent enhancement of coronavirus entry Extensive complement-dependent enhancement of HIV-1 by autologous non-neutralising antibodies at early stages of infection Antibodydependent enhancement of Ebola virus infection The convalescent sera option for containing COVID-19 Management of COVID-19 virus infection by convalescent plasma Immune-epidemiological parameters of the novel coronavirus -a perspective Temporal dynamics in viral shedding and transmissibility of COVID-19 Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Acknowledgments Based on these reports, the administration of plasmapheresis and IVIG should be promptly administered to COVID-19 patients in order to have the highest efficacy in their treatment [7, 26, 27] .


id: cord-337026-osgi06o4
author: Panoutsopoulos, Alexios A.
title: Conjunctivitis as a Sentinel of SARS-CoV-2 Infection: a Need of Revision for Mild Symptoms
date: 2020-06-19
extension: .txt
mime: text/plain
words: 3183
sentence: 111
flesch: 38
cache: cache/cord-337026-osgi06o4.txt
txt: txt/cord-337026-osgi06o4.txt
summary:
  The Molecular Biology of Coronaviruses and SARS-CoV-2 Coronaviruses (CoVs) are RNA viruses with the largest RNA in base length identified so far and belong to the Coronaviridae family. Except for DNA viruses though, RNA viruses are often associated with conjunctivitis.


id: cord-320612-vam0bli3
author: Höring, Steffen
title: Management of a Hospital-Wide COVID-19 Outbreak Affecting Patients and Healthcare Workers
date: 2020-10-26
extension: .txt
mime: text/plain
words: 3417
sentence: 154
flesch: 44
cache: cache/cord-320612-vam0bli3.txt
txt: txt/cord-320612-vam0bli3.txt
summary:
  The reduction of contacts between geriatric patients was partially challenging since several patients suffered from cognitive impairment and did not follow social distancing recommendations or single-room isolation. Most affected patients were bedridden and had no contact with other patients.


id: cord-284545-vn60yd46
author: Sanyaolu, Adekunle
title: Comorbidity and its Impact on Patients with COVID-19
date: 2020-06-25
extension: .txt
mime: text/plain
words: 3752
sentence: 183
flesch: 50
cache: cache/cord-284545-vn60yd46.txt
txt: txt/cord-284545-vn60yd46.txt
summary:
  In the USA, the Centers for Disease Control and Prevention (CDC) uses COVID-NET in 14 states to monitor the demographics of COVID-19 patients who are being hospitalized [6] . A meta-analysis study of COVID-19 patients, as depicted in Fig. 1 , showed fever (88.8%) as the most common symptom, followed by dry cough (68%) and fatigue (33%)


id: cord-336689-z3ayolzb
author: Gaur, Uma
title: Challenges and Opportunities of Preclinical Medical Education: COVID-19 Crisis and Beyond
date: 2020-09-22
extension: .txt
mime: text/plain
words: 3646
sentence: 169
flesch: 34
cache: cache/cord-336689-z3ayolzb.txt
txt: txt/cord-336689-z3ayolzb.txt
summary:
  The unprecedented use of online pedagogy as an emergency measure during COVID-19 period, with an adaptation to the new normal to deliver preclinical medical education, has brought both challenges and opportunities to medical education While COVID-19 has thrown many challenges for preclinical medical education, it has also created opportunities-academic leaders with servant leadership, distribution of leadership responsibilities, and clear lines of communication dealt with the situation aptly [1, [16]


id: cord-300866-cso6l6ze
author: Bao, Yi
title: Clinical Features of COVID-19 in a Young Man with Massive Cerebral Hemorrhage—Case Report
date: 2020-05-23
extension: .txt
mime: text/plain
words: 4256
sentence: 179
flesch: 46
cache: cache/cord-300866-cso6l6ze.txt
txt: txt/cord-300866-cso6l6ze.txt
summary:
  The treatment of COVID-19 patients with intracerebral hemorrhage suggesting that antiviral treatment was effective. Contact history of the epidemic area and close contact history of COVID-19 confirmed patients were denied.


id: cord-028923-gzqd5g0k
author: Vitug, Sarah
title: Sedation with ketamine and fentanyl combination improves patient outcomes in intensive care units
date: 2020-07-10
extension: .txt
mime: text/plain
words: 1068
sentence: 45
flesch: 25
cache: cache/cord-028923-gzqd5g0k.txt
txt: txt/cord-028923-gzqd5g0k.txt
summary:
  We acknowledge that even lowdose ketamine and supplementary analgesic/sedative agents can precipitate unwanted medication-induced psychotic symptoms and other side effects; thus, continued close monitoring of postoperative ICU patients under this multimodal regimen is advised. key: cord-028923-gzqd5g0k authors: Vitug, Sarah; Ravi, Vikas; Thangathurai, Duraiyah title: Sedation with ketamine and fentanyl combination improves patient outcomes in intensive care units date: 2020-07-10 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00275-3 sha: doc_id: 28923 cord_uid: gzqd5g0k Psychological manifestations such as depression and suicidal ideation are commonly caused by poorly controlled pain, anxiety, and sleep deprivation in intensive care unit (ICU) patients.


id: cord-273829-t5cuop5c
author: Görgülü, Özkan
title: rRT-PCR Results of a Covid-19 Diagnosed Geriatric Patient
date: 2020-10-17
extension: .txt
mime: text/plain
words: 1490
sentence: 66
flesch: 46
cache: cache/cord-273829-t5cuop5c.txt
txt: txt/cord-273829-t5cuop5c.txt
summary:
  The nucleic acid test functions as the gold standard method for confirming the SARS-COV-2 infection; however, some recent studies have detected false negative results of real-time reverse transcriptase polymerase chain reaction (rRT-PCR) Both lung and cardiovascular injuries are common in the management of COVID-19 infections, especially those with only cardiovascular disease symptoms [7] .


id: cord-300320-07tdrd4w
author: Siordia, Juan A.
title: Systematic and Statistical Review of Coronavirus Disease 19 Treatment Trials
date: 2020-07-15
extension: .txt
mime: text/plain
words: 4849
sentence: 314
flesch: 42
cache: cache/cord-300320-07tdrd4w.txt
txt: txt/cord-300320-07tdrd4w.txt
summary:
  key: cord-300320-07tdrd4w authors: Siordia, Juan A.; Bernaba, Michael; Yoshino, Kenji; Ulhaque, Abid; Kumar, Sooraj; Bernaba, Mario; Bergin, Edward title: Systematic and Statistical Review of Coronavirus Disease 19 Treatment Trials date: 2020-07-15 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00399-6 sha: doc_id: 300320 cord_uid: 07tdrd4w The following systematic review and meta-analysis compile the current data regarding human controlled COVID-19 treatment trials. The following systematic and statistical review assesses the current evidence regarding human controlled COVID-19 treatment trials.


id: cord-269425-e9iyso7n
author: Bhattacharjee, Sukrita
title: Immune Thrombocytopenia Secondary to COVID-19: a Systematic Review
date: 2020-09-19
extension: .txt
mime: text/plain
words: 5429
sentence: 273
flesch: 43
cache: cache/cord-269425-e9iyso7n.txt
txt: txt/cord-269425-e9iyso7n.txt
summary:
  A systematic review was done to analyze the clinical profile and outcomes in a total of 45 cases of new-onset ITP in COVID-19 patients described in literature until date. Clinicians should also take note of several reports of ITP in COVID-19 patients in post-recovery period (21%).


id: cord-254631-80sg4uvd
author: Llansó, Laura
title: Posterior Reversible Encephalopathy Syndrome in COVID-19 Disease: a Case-Report
date: 2020-08-26
extension: .txt
mime: text/plain
words: 1037
sentence: 45
flesch: 32
cache: cache/cord-254631-80sg4uvd.txt
txt: txt/cord-254631-80sg4uvd.txt
summary:
  We report a case of posterior reversible encephalopathy syndrome in a patient with COVID-19 disease, possibly related to anti-IL-1 or anti-IL-6, suggesting that anti-interleukin treatments may cause this syndrome, at least in patients with predisposing conditions such as infections and hydroelectrolytic disorders. Considering the infectious background, the immunomodulatory treatments, modest hypertension in the hours before the symptoms, and the distribution of the lesions on the CT scan, the most likely diagnosis is posterior reversible encephalopathy syndrome (PRES)


id: cord-348121-c7jq240j
author: Tagliabue, Fabio
title: The “Pandemic” of Disinformation in COVID-19
date: 2020-08-01
extension: .txt
mime: text/plain
words: 1515
sentence: 53
flesch: 37
cache: cache/cord-348121-c7jq240j.txt
txt: txt/cord-348121-c7jq240j.txt
summary:
  During the COVID-19 epidemic, misinformation and fake news have represented an important issue generating confusion and insecurity among the population. The general population has, in good faith, taken the information, including fake news, most relevant to their own personal situation and has used it to formulate their own interpretation of the pandemic.


id: cord-347926-63w578b2
author: Ruan, Pei-sen
title: COVID-19 in Children: Clinical Characteristics and Follow-Up Study
date: 2020-09-03
extension: .txt
mime: text/plain
words: 1206
sentence: 57
flesch: 46
cache: cache/cord-347926-63w578b2.txt
txt: txt/cord-347926-63w578b2.txt
summary:
  Many researchers had reported that varieties of cases of recovered COVID-19 pediatric patients had positive RT-PCR test again. At present, pediatric patients have been reported all over the world, mainly asymptomatic and mild infections.


id: cord-344217-kci4uw7u
author: Majid, Sabhiya
date: 2020-08-25
extension: .txt
mime: text/plain
words: 5657
sentence: 228
flesch: 39
cache: cache/cord-344217-kci4uw7u.txt
txt: txt/cord-344217-kci4uw7u.txt
title:
  Managing the COVID-19 Pandemic: Research Strategies Based on the Evolutionary and Molecular Characteristics of Coronaviruses

summary:
  mSphere Multibasic cleavage site in the spike protein of SARS-CoV-2 is essential for infection of human lung cells Structure of SARS coronavirus spike receptor binding domain complexed with the receptor Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4 The bittersweet promise of glycobiology The novel coronavirus2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Human coronavirus NL63employs the severe acute respiratory syndrome coronavirus receptor for cellular entry ACE2 of the heart: from angiotensin I to angiotensin (1-7) Identification of a coronavirus hemagglutinin-esterase with a substrate specificity different from those of influenza C virus and bovine coronavirus COVID-19 infection: origin, transmission, and characteristics of human coronaviruses Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China The Association of Cardiovascular Diseases and Diabetes Mellitus with COVID-19 (SARS-CoV-2) and their possible mechanisms Crystal structure of NL63 respiratory coronavirus receptor-binding complexed with its human receptor Structural basis of receptor recognition by SARS-CoV-2 Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with ACE Clinical management of adult coronavirus infection disease 2019 (COVID-19) positive in the setting of low and medium intensity of care: a short practical review Master regulator analysis of the SARS-CoV-2 /human interactome COVID-19 outbreak: an update on therapeutic options Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations SN Compr Clin Med Cryo-electron tomography of mouse hepatitis virus: insights into the structure of the coronavirion The molecular biology of coronaviruses Coronavirus: organization, replication and expression of genome Mechanisms and enzymes involved in SARS coronavirus genome expression Pre-fusion structure of a human coronavirus spike protein The M, E, and N structural proteins of the severe acute respiratory syndrome coronavirus are required for efficient assembly, trafficking, and release of virus-like particles


id: cord-317956-srbualjc
author: Klang, Eyal
title: Sex Differences in Age and Comorbidities for COVID-19 Mortality in Urban New York City
date: 2020-08-09
extension: .txt
mime: text/plain
words: 1522
sentence: 84
flesch: 53
cache: cache/cord-317956-srbualjc.txt
txt: txt/cord-317956-srbualjc.txt
summary:
  The link between gender and the severity of COVID-19 disease is still not completely understood. The model was adjusted for age and comorbidities known to be associated with COVID-19 mortality.


id: cord-303959-e1654g5j
author: Vitiello, Antonio
date: 2020-08-27
extension: .txt
mime: text/plain
words: 1919
sentence: 63
flesch: 29
cache: cache/cord-303959-e1654g5j.txt
txt: txt/cord-303959-e1654g5j.txt
title:
  COVID-19 Patients with Pulmonary Fibrotic Tissue: Clinical Pharmacological Rational of Antifibrotic Therapy

summary:
  In this article, we describe the advantages of antifibrotic therapy in patients with ongoing SARS-CoV-2 viral infection to prevent the worsening and aggravation of the clinical situation, and the advantages it could have in the role of preventing pulmonary fibrosis after SARS-CoV-2 infection, and in accelerating the complete healing process. SARS-CoV-2 infection can have a completely asymptomatic or mildly symptomatic course, but in some cases, it can also cause systemic hyperinflammation, pulmonary fibrosis and scarring with lung collapse, multi-organ dysfunction, and patient death


id: cord-322596-vfmzk2el
author: Ming, Yi
title: Involvement of Spike Protein, Furin, and ACE2 in SARS-CoV-2-Related Cardiovascular Complications
date: 2020-07-11
extension: .txt
mime: text/plain
words: 3612
sentence: 137
flesch: 36
cache: cache/cord-322596-vfmzk2el.txt
txt: txt/cord-322596-vfmzk2el.txt
summary:
  The biological process of Furin processing and activation of coronavirus S protein to expose the reactive domain also explains partially the phenomenon of COVID-19 with severe cardiovascular damage. Moreover, based on the role of furin protein in cardiovascular disease, its inhibitors might also improve cardiovascular prognosis and reduce critical deaths.


id: cord-029137-mck5cmn7
author: Krasnanova, Veronika
date: 2020-07-13
extension: .txt
mime: text/plain
words: 1745
sentence: 87
flesch: 32
cache: cache/cord-029137-mck5cmn7.txt
txt: txt/cord-029137-mck5cmn7.txt
title:
  Tigecycline Therapy for Multi-drug-Resistant Pseudomonas aeruginosa Sepsis Associated with Multi-organ Failure in an Infant with Persistent Arterial Duct. Case Report

summary:
  Within 48 h, inflammatory markers started to decrease and tigecycline therapy continued for 13 days without adverse effects. Tigecycline therapy continued for 13 days without adverse effects.


id: cord-339332-6lml531t
author: Karia, Rutu
title: COVID-19 and its Modes of Transmission
date: 2020-09-01
extension: .txt
mime: text/plain
words: 2266
sentence: 105
flesch: 49
cache: cache/cord-339332-6lml531t.txt
txt: txt/cord-339332-6lml531t.txt
summary:
  This increases the amount of exposure and, thus, the risk of virus transmission [6] . Ren et al. found that urine of an asymptomatic patient was positive for viral nucleic acid and concluded that urine may serve as a mode of virus transmission


id: cord-312730-4ejjmab4
author: Wong, Rebecca S. Y.
title: The SARS-CoV-2 Outbreak: an Epidemiological and Clinical Perspective
date: 2020-09-29
extension: .txt
mime: text/plain
words: 6486
sentence: 260
flesch: 47
cache: cache/cord-312730-4ejjmab4.txt
txt: txt/cord-312730-4ejjmab4.txt
summary:
  [43] whereas another study reported that HIV was associated with a doubling of mortality risk in COVID-19 patients medRxiv preprint 2020 Effects of temperature and humidity on the daily new cases and new deaths of COVID-19 in 166 countries The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells Pathogenesis of COVID-19 from a cell biology perspective Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Centre for Disease Control and Prevention SARS-Cov-2 infection: response of human immune system and possible implications for the rapid test and treatment Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in Wuhan, China Extrapulmonary and atypical clinical presentations of COVID-19 Extrapulmonary manifestations of COVID-19: radiologic and clinical overview Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicentre study Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases Cardiovascular disease and COVID-19 Epidemiological characteristics of 2143 paediatric patients with 2019 coronavirus disease in China Toxic shock-like syndrome and COVID-19: a case report of multisystem inflammatory syndrome in children (MIS-C) Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic Clinical analysis of ten pregnant women with COVID-19 in Wuhan, China: a retrospective study Clinical presentation and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis Clinical features and outcomes of HIV patients with coronavirus disease 2019 HIV and risk of COVID-19 death: a population cohort study from the Western Cape Province, South Africa.


id: cord-273459-3686wv7v
author: Fang, Lanlan
title: Analysis and Estimation of COVID-19 Spreading in Russia Based on ARIMA Model
date: 2020-10-09
extension: .txt
mime: text/plain
words: 2730
sentence: 129
flesch: 55
cache: cache/cord-273459-3686wv7v.txt
txt: txt/cord-273459-3686wv7v.txt
summary:
  Modeling and forecasting of epidemic spreading: the case of Covid-19 and beyond Study on the epidemic development of corona virus disease-19 (COVID-19) in Hubei province by a modified SEIR model Modified SEIR and AI prediction of the epidemics trend of COVID-19 in China under public health interventions Forecasting Covid-19 dynamics in Brazil: a data driven approach Optimization method for forecasting confirmed cases of COVID-19 in China Strengths, weaknesses, opportunities, and threats analysis of artificial intelligence and machine learning applications in radiology Using autoregressive integrated moving average (ARIMA) models to predict and monitor the number of beds occupied during a SARS outbreak in a tertiary hospital in Singapore Epidemiological features and forecast model analysis for the morbidity of influenza in Prediction of the COVID-19 pandemic for the top 15 affected countries: advanced autoregressive integrated moving average (ARIMA) model Reducing demand uncertainty in the platelet supply chain through artificial neural networks and ARIMA models The analysis of time series: an introduction Time series analysis: forecasting and control, 5th edition Permeate flux prediction in the ultrafiltration of fruit juices by ARIMA models Application of a combined model with seasonal autoregressive integrated moving average and support vector regression in forecasting hand-footmouth disease incidence in Wuhan Comparison of ARIMA and GM(1, 1) models for prediction of hepatitis B in China Estimation of COVID-19 prevalence in Italy Exponentially increasing trend of infected patients with COVID-19 in Iran: a comparison of neural network and ARIMA forecasting models Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations The data from January 31 to May 20 is used as a training set to build ARIMA models, and the data from May 21 to May 30 is used as a verification set to test the accuracy of these models.


id: cord-261222-762nqkbg
author: Sachdeva, Sonali
date: 2020-10-12
extension: .txt
mime: text/plain
words: 2847
sentence: 114
flesch: 42
cache: cache/cord-261222-762nqkbg.txt
txt: txt/cord-261222-762nqkbg.txt
title:
  Admission Hyperglycemia in Non-diabetics Predicts Mortality and Disease Severity in COVID-19: a Pooled Analysis and Meta-summary of Literature

summary:
  Studies have shown that COVID-19 patients with hyperglycemia are older compared with those with normal blood glucose levels. Men comprised a larger proportion of COVID-19 patients presenting with impaired fasting glucose, compared with those without hyperglycemia (55% vs 34%).


id: cord-341987-lsvifqyo
author: Kalyanasundaram, Sridhar
title: Novel Corona Virus Pandemic and Neonatal Care: It’s Too Early to Speculate on Impact!
date: 2020-08-03
extension: .txt
mime: text/plain
words: 3969
sentence: 179
flesch: 48
cache: cache/cord-341987-lsvifqyo.txt
txt: txt/cord-341987-lsvifqyo.txt
summary:
  Children are less susceptible to COVID-19 infection and generally have a mild course. Children are less susceptible to COVID-19 infection and generally have a mild course in newborns, and children experience with significantly lower death rates [3, 4] .


id: cord-303731-yrlzxtbw
author: Fong, Raymond
title: Management of Dysphagia in Nursing Homes During the COVID-19 Pandemic: Strategies and Experiences
date: 2020-08-18
extension: .txt
mime: text/plain
words: 2902
sentence: 130
flesch: 40
cache: cache/cord-303731-yrlzxtbw.txt
txt: txt/cord-303731-yrlzxtbw.txt
summary:
  key: cord-303731-yrlzxtbw authors: Fong, Raymond; Tsai, Kelvin C. F.; Tong, Michael C. F.; Lee, Kathy Y. S. title: Management of Dysphagia in Nursing Homes During the COVID-19 Pandemic: Strategies and Experiences date: 2020-08-18 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00464-0 sha: doc_id: 303731 cord_uid: yrlzxtbw The global 2019 novel coronavirus disease (COVID-19) pandemic has had devastating effects not only on healthcare systems worldwide but also on different aspects of the care provided to nursing home residents. Dysphagia is a prevalent problem among nursing home residents.


id: cord-330690-cupy89gl
author: Vierucci, Francesco
date: 2020-09-23
extension: .txt
mime: text/plain
words: 4334
sentence: 160
flesch: 36
cache: cache/cord-330690-cupy89gl.txt
txt: txt/cord-330690-cupy89gl.txt
title:
  How COVID-19 Pandemic Changed Children and Adolescents Use of the Emergency Department: the Experience of a Secondary Care Pediatric Unit in Central Italy

summary:
  We also evaluated the number of pediatric ED visits performed monthly from January 1st to May 31st, 2020, for selected infectious and non-infectious diseases. Monthly comparison of pediatric ED visits performed from January to May 2020 confirmed a significant reduction in daily consultations after February, with a considerable percentage of days with ≤ 3 visits/day (Table 1) .


id: cord-335095-epsi5qq7
author: Feng, Gong
title: Clinical Features of COVID-19 Patients in Xiaogan City
date: 2020-08-24
extension: .txt
mime: text/plain
words: 2804
sentence: 123
flesch: 51
cache: cache/cord-335095-epsi5qq7.txt
txt: txt/cord-335095-epsi5qq7.txt
summary:
  The objectives are to study the clinical features of COVID-19 patients and assess the relationship between the severity of COVID-19, age, and C-reactive protein (CRP) levels. This study documented COVID-19 patients.


id: cord-268617-1t7yaoct
author: Ismaili, Nabil
title: COVID-19 and Gynecological Cancers: A Summary of International Recommendations
date: 2020-08-31
extension: .txt
mime: text/plain
words: 3986
sentence: 178
flesch: 38
cache: cache/cord-268617-1t7yaoct.txt
txt: txt/cord-268617-1t7yaoct.txt
summary:
  Cancer patients are more susceptible to develop an infection than people without cancer because of their immunosuppression caused by the disease and treatments (surgery and chemotherapy). Cancer patients are more susceptible to develop an infection than people without cancer because of their immunosuppression caused by the disease and treatments, such as chemotherapy and/or surgery.


id: cord-276132-tv5y1eqc
author: Ray, Upasana
title: COVID-19: The Impact in Oncology Care
date: 2020-10-23
extension: .txt
mime: text/plain
words: 5705
sentence: 193
flesch: 33
cache: cache/cord-276132-tv5y1eqc.txt
txt: txt/cord-276132-tv5y1eqc.txt
summary:
  The crisis stage deals with when the system over surpluses with the COVID-19 cases and deprived of its ability to provide cancer patient care. With the increasing risk of cancer patients acquiring infection during receiving the essential care, the debate ensues on how to balance the risk factors and benefits out of the oncologic emergencies in cancer patients.


id: cord-340305-jtvn9tlm
author: Cimolai, Nevio
title: A Minimalist Strategy Towards Temporarily Defining Protection for COVID-19
date: 2020-09-19
extension: .txt
mime: text/plain
words: 5117
sentence: 211
flesch: 33
cache: cache/cord-340305-jtvn9tlm.txt
txt: txt/cord-340305-jtvn9tlm.txt
summary:
  Glob Health Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamsters Comparison of immunoglobulin G responses to the spike and nucleocapsid proteins of severe acute respiratory syndrome (SARS) coronavirus in patients with SARS Potently neutralizing and protective human antibodies against SARS-CoV-2 Potent neutralizing antibodies against SARS-CoV-2 identified by highthroughput single-cell sequencing of convalescent patients' B cells Shahverdi S Clinical efficacy and convalescent plasma for treatment of COVID-19 infections: results of a multicenter clinical study Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development A SARS-CoV-2 neutralizing antibody protects from lung pathology in COVID-19 hamster model Passive immunization against transmissible gastroenteritis virus in piglets by ingestion of milk of sows inoculated with attenuated virus Effect of specific humoral immunity and some nonspecific factors on resistance of volunteers to respiratory coronavirus infection Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in rhesus macaques Protective effect of immunoglobulins in serum and milk of sows exposed to transmissible gastroenteritis virus Neutralization of a transmissible gastroenteritis virus of swine by colostral antibodies elicited by intestine and cell culture-propagated virus Intestinal, pulmonary, and serum antibody responses of feeder pigs exposed to transmissible gastroenteritis virus by the oral and the oral-intranasal routes in inoculation Mucosal and systemic isotype-specific antibody responses and protection in conventional pigs exposed to virulent or attenuated porcine epidemic diarrhoea virus Isotype-specific antibody responses to bovine coronavirus structural proteins in serum, feces, and mucosal secretions from experimentally challengeexposed colostrum-deprived calves Primary exposure to SARS-CoV-2 protects against reinfection in Rhesus macaques Relationship among transmissible gastroenteritis virus antibody titers in serum, colostrum, and milk from vaccinated sows, and protection in their suckling pigs Passive protection of neonatal calves against bovine coronavirus-induced diarrhea by administration of egg yolk or colostrum antibody powder The time course of the immune response to experimental coronavirus infection of man Infectious Middle East Respiratory Syndrome coronavirus excretion and serotype variability based on live virus isolates from patients in Saudi Arabia Viral shedding and antibody response in 37 patients with Middle East Respiratory Syndrome coronavirus infection Sensitive and specific detection of low-level antibody responses in mild Middle East Respiratory Syndrome coronavirus infections MERS-CoV antibody responses 1 year after symptom onset, South Korea Persistence of antibodies against Middle East Respiratory Syndrome coronavirus High neutralizing antibody titer in intensive care unit patients with COVID-19 Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2 Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections Evaluating the association of clinical characteristics with neutralizing antibody levels in patients who have recovered from mild COVID-19 in Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications on COVID-19 immunity Dynamics and significance of the antibody response to SARS-CoV-2 infection Humoral and cellular and circulating follicular helper T cell responses in recovered patients with COVID-19 Antibody profiles according to mild or severe SARS-CoV-2 infection Human-IgGneutralizing monoclonal antibodies block the SARS-CoV-2 infection Rapid generation of neutralizing antibody responses in COVID-19 patients Severe acute respiratory syndrome coronavirus 2-specific antibody responses in coronavirus disease patients Expansion of SARS-CoV-2-specific antibody-secreting cells and generation of neutralizing antibodies in hospitalized COVID-19 patients Antibody response to SARS-CoV-2 are distinct in children with MIS-C compared to adults with COVID-19 Pediatric SARS-CoV-2: clinical presentation, infectivity, and immune responses SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19 SARS-CoV-2 serology and virology trends in donors and recipients of convalescent plasma Viral dynamics and immune correlates of COVID-19 disease severity Anti SARS-CoV-2 antibodies monitoring in a group of residents in a long term care facility during COVID-19 pandemic peak Sex differences in immune responses that underlie COVID-19 disease outcomes Development and characterization of neutralizing monoclonal antibody to the SARS-coronavirus The behavior of recent isolates of human respiratory coronavirus in vitro and in volunteers: evidence of heterogeneity among 229E-related strains Sequential emergence and wide spread of neutralization escape Middle East Respiratory Syndrome coronavirus mutants Increased antibody affinity confers broad in vitro protection against escape mutants of severe acute respiratory syndrome coronavirus COVID-19 re-infection by a phylogenetically distinct SARScoronavirus-2 strain confirmed by whole genome sequencing Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals Functional SARS-CoV-2-specific immune m e m Does neutralization antibody ensure protection?


id: cord-295041-5vpawtef
author: Jakhmola, Shweta
title: SARS-CoV-2, an Underestimated Pathogen of the Nervous System
date: 2020-09-28
extension: .txt
mime: text/plain
words: 5028
sentence: 252
flesch: 35
cache: cache/cord-295041-5vpawtef.txt
txt: txt/cord-295041-5vpawtef.txt
summary:
  Cochrane Database Syst Rev SARS-CoV-2: recent reports on antiviral therapies based on lopinavir/ritonavir, darunavir/ umifenovir, hydroxychloroquine, remdesivir, favipiravir and other drugs for the treatment of the new coronavirus Amantadine disrupts lysosomal gene expression: a hypothesis for COVID19 treatment TH17 responses in cytokine storm of COVID-19: an emerging target of JAK2 inhibitor Fedratinib Proinflammatory cytokines and chemokines in humans with Japanese encephalitis COVID-19 in a MS patient treated with ocrelizumab: does immunosuppression have a protective role? Neuroinflammation during RNA viral infections Inflammatory activation of microglia and astrocytes in manganese neurotoxicity Microglia in infectious diseases of the central nervous system Astrocytes maintain glutamate homeostasis in the CNS by controlling the balance between glutamate uptake and release Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin IIexposed microglial cells: role of renin-angiotensin system Within the brain: the renin angiotensin system Coronavirus neurovirulence correlates with the ability of the virus to induce proinflammatory cytokine signals from astrocytes and microglia Hematological findings in SARS patients and possible mechanisms (review) Activation of human monocytes after infection by human coronavirus 229E Understanding SARS-CoV-2-Mediated inflammatory responses: from mechanisms to potential therapeutic tools COVID-19: consider cytokine storm syndromes and immunosuppression Angiotensin-converting enzyme 2: central regulator for cardiovascular function ACE2 in brain physiology and pathophysiology: evidence from transgenic animal models Inhibitory interneurons regulate temporal precision and correlations in cortical circuits Angiotensin II regulation of angiotensin-converting enzymes in spontaneously hypertensive rat primary astrocyte cultures SARS-CoV2 entry and spread in the lymphatic drainage system of the brain Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms Can the enteric nervous system be an alternative entrance door in SARS-CoV2 neuroinvasion? SARS-CoV-2 productively infects human gut enterocytes The pivotal link between ACE2 deficiency and SARS-CoV-2 infection SARS-CoV-2: olfaction, brain infection, and the urgent need for clinical samples allowing earlier virus detection The olfactory bulb: an immunosensory effector organ during neurotropic viral infections Respiratory barrier as a safeguard and regulator of defense against influenza A virus and Single-cell analysis of olfactory neurogenesis and differentiation in adult humans Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2 Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures Hierarchical deconstruction of mouse olfactory sensory neurons: from whole mucosa to single-cell RNA-seq A multibasic cleavage site in the spike protein of SARS-CoV-2 is essential for infection of human lung cells Furin at the cutting edge: from protein traffic to embryogenesis and disease Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations T helper cell 17 (Th17)-mediated cytokine storm, evident in virus infections, is seen in COVID-19 with neurological manifestations (Fig. 1b)


id: cord-285748-us5do6c2
author: Cheng, Yongqian
title: SARS-CoV-2-Related Kidney Injury: Current Concern and Challenges
date: 2020-09-23
extension: .txt
mime: text/plain
words: 5333
sentence: 240
flesch: 44
cache: cache/cord-285748-us5do6c2.txt
txt: txt/cord-285748-us5do6c2.txt
summary:
  The prevalence of CKD was 0-5.6%, which represents a minor proportion in COVID-19 patients [6, [8] Some studies about renal function in COVID-19 patients have shown common manifestations of kidney dysfunctions and incidental acute kidney injury


# url

id: cord-276132-tv5y1eqc
domain: www.latimes.com
url:
  www.latimes.com/science/story/2020-03-31/coronavirusdeath-rate-estimates-show-risk-rising-sharply-with-age


# ent

id: cord-276132-tv5y1eqc
sid: 59
eid: 1
type: ORG
entity:
  medpagetoday.com/infectiousdisease/covid19/86144, https:// www.ucsf.edu/news/2020/05/417411/smoking-nearlydoubles-rate-covid-19-progression


