SUPPLEMENTARY TABLE ST1. Validated PROMs used in the studies included in the systematic review Questionnaire Abbreviation Author (Year publication) Measurement Original Target Population 36-item Short Form Health Survey[1] SF-36 (G) Ware & Sherbourne (1992) Physical and mental health status for use in clinical practice and research, health policy evaluations and general population survey Medical and general population 12-item Short-Form Health Survey[2] SF-12(G) Ware et al. (1996) Physical and mental health status for use in clinical practice and research, health policy evaluations and general population survey Medical and general population EORTC Quality of life questionnaire[3]a EORTC QLQ-C30 (CS) Aaronson et al. (1993) Five functional (physical, role, cognitive, emotional, and social), three symptom scales and single-item symptom measures plus a global health and quality of life scale Patients with cancer participating in international trials (originally in nonresectable lung cancer for whom radiotherapy or chemotherapy was indicated) Cancer Rehabilitation Evaluation System - Short Form[4] CARES-SF (CS) Schag et al. (1991) Cancer-specific rehabilitation needs and quality of life Patients with cancer (originally in colorectal, lung, prostate, and breast cancer) Impact of Events Scale[5] IES Disease specific Horowitz et al. (1979) Psychological stress reactions after any major life events (frequency of intrusive thoughts and avoidance behaviour) Healthy adults and frail older adults exposed to any specific trauma event Impact of Events Scale Revised[6] IES-R Disease specific Weiss & Marmar (1997) Psychological stress reactions after any major life events (Intrusive thoughts, avoidance behaviour and hyperarousal) Healthy and frail older adults exposed to any specific trauma Eastern Cooperative Oncology Group Performance Status[7] ECOG (CS) Oken et al. (1982) Patients’ general well-being and activities of daily life (to determine whether they can receive chemotherapy, if dose adjustment is necessary and to assess the intensity of palliative care) Cancer patients candidates to receive chemotherapy or palliative care Fear of Cancer Recurrence[8] FCR (CS) Greenberg et al. (1997) Beliefs and anxiety about fear of cancer recurrence Cancer survivors (mainly breast and leukemia) General Health Questionnaire[9] GHQ-12 Condition specific Goldberg (1978) General state of health and emotional mental health problems/domains of depression, anxiety, somatic symptoms, and social withdrawal (current psychological distress) Individuals at risk to have or developing psychiatric disorders including primary care Hospital Anxiety and Depression Scale[10] HADS (Condition specific) Zigmond & Snaith (1983) Anxiety and depression Medical population of patients List of Threatening Experiences Questionnaire[11] LTE-Q Condition specific Brugha & Cragg (1990) 12 major stressful life events in the last 6 months with established long-term consequences Individuals with suspicion of any stressful situation (originally tested in psychiatric patients) Postoperative Quality of Recovery Score[12] QoR-40 Condition specific Myles et al. (2000) Quality of recovery after surgery and anaesthesia Patients undergoing general anaesthesia and surgery Social Problem Questionnaire[13] SPQ Condition specific Corney & Clare (1985) Social functioning (social problems, difficulties, and dissatisfaction) Patients that require social assessment Visual Analogue Scale[14]b VAS Generic Aitken (1969) Intensity or frequency of symptoms or satisfaction that ranges across a continuum of values from none to extreme Patients and healthy individuals / general population Functional Assessment of Cancer Therapy -Kidney Symptoms Index[15] FKSI -15 Cancer specific Cella et al. (2006) Renal cancer specific symptoms and concerns (fatigue, fever, loss of appetite, weight loss, hematuria, pain, pulmonary or urinary symptoms, distress or worry Patients with advanced kidney cancer a For EORTC QOL C-30 questionnaires, versions 1.0, (+3), 2.0 and 3.0 were used in the different studies. As per instructions in EORTC QLQ C-30 Scoring Manual the original publication is cited. b Used early in the 20th century, popularized by Aitken in 1969 (Guidelines for the Application Scoring and Statistical Analysis of VAS) References 1. Ware JE, Sherbourne CD. The MOS 36-Item Short-Form Health Survey (SF-36): I. Conceptual framework and item selection. Med Care.1992;30:473–483. 2. Ware J Jr, Kosinski M, Keller SD. A 12-item short-form health sur vey: cons t r uc tion of s c ales and pr eliminar y tes t s of reliabilit y and validit y. Med C are.19 9 6;3 4:2 2 0 –2 3 3. doi: 10.1097/00005650-199603000-00003 3. Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life Instrument for use in International Clinical Trials in Oncology. J Natl Cancer Inst.1993;85:365–376. doi: 10.1093/jnci/85.5.365 4. Coscarelli-Schag CA, Ganz PA, Heinrich RL. Cancer rehabilitation evaluation system-short form (CARES-SF). Cancer.1991;68:1406– 1413 . d o i:10 .10 0 2 / 10 9 7- 0 14 2 (19 9 10 9 15 ) 6 8 : 6 < 14 0 6 : : a i d - cncr2820680638>3.0.co;2-2 5. Horowitz M, Wilner N, Alvarez W. Impact of event scale: a measure of subjective stress. Psychosom Med.1979; 41: 209 –218. doi: 10.1097/00006842-197905000-00004 6. Weiss DS, Marmar CR. The impact of Event scale-revised. In: Wilson JP, Keane TM, eds. Assessing psychological trauma and PTSD. New York: Guilford Press;1997. pp.399–411. 7. Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden PP, et al. Toxicity and response criteria of the Eastern Cooperative Oncology group. Am J Clin Oncol.1982;5:649–655. 8. Greenberg DB, Kornblith AB, Herndon JE, Zuckerman E, Schiffer CA, Weiss RB, et al. Quality of life for adult leukemia survivors treated on clinical trials of cancer and leukemia group B during the period 1971-1988. Cancer.1997;80:1937–1944. doi: 10.1002/ (sici)1097-0142(19971115)80:10<1936::aid-cncr10>3.0.co;2-z. 9. Goldberg DP. Manual of the General Health Questionnaire. Windsor, England; NFER Publishing, 1978. 10. Zigmond AS, Snaith RP. The hospital anxiety and depression Scale. Acta Psychiatr Scand.1983;67:361–370. doi: 10.1111/j.1600-0447.1983. tb09716.x. 11. Brugha TS, Cragg D. The list of threatening experiences: the reliability and validity of a brief life events questionnaire. Acta Psychiatr Scand.1990:82:77–81. doi: 10.1111/j.1600-0447.1990.tb01360.x. 12. Myles PS, Weitkamp B, Jones K, Hensen S. Validity and reliability of a postoperative quality of recovery score: the QoR-40. Br J Anaesth.2000;84:1:11–15. doi: 10.1093/oxfordjournals.bja.a013366. 13. Corney RH, Clare AW. The construction, development and testing of a self-report questionnaire to identify social problems. Psychol Med.1985;15:637–649. doi: 10.1017/s0033291700031494. 14. Aitken RCB. Measurement of feelings using visual analogue scales. Proc R Soc Med.1969;62:989–993. 15. Cella D, Yount S, Du H, Dhanada R, Gondek K, Langefeld K, et al. development and validation of the Functional Assessment of Cancer Therapy-Kidney Symptoms Index (FKSI). J Suppor t Oncol.2006;4:191-199.