361SIUJ.ORG SIUJ • Volume 3, Number 6 • November 2022 Editorial Tackling Kidney Cancer Through International Consensus 363 Philippe E. Spiess Urology Around The World Why Should the Indian Urology and Oncology Community Be “Aatmanirbhar” in Penile Cancer Research 367 Prakash Gagan 2nd WUOF/SIU-ICUD on Kidney Cancer Chapter Summaries Kidney Cancer Screening and Epidemiology 371 Sabrina H. Rossi, Hajime Tanaka, Juliet A. Usher-Smith, Jean-Christophe Bernhard, Yasuhisa Fujii, Grant D. Stewart Genetics and Tumor Microenvironment of Renal Cell Carcinoma 386 Sari Khaleel, Christopher Ricketts, W. Marston Linehan, Mark Ball, Brandon Manley, Samra Turajilic, James Brugarolas, Ari Hakimi Hereditary Renal Cell Carcinoma Syndromes 397 Jodi K. Maranchie, Brian M. Shuch, Gennady Bratslavsky, Eamonn R. Maher Imaging of Renal Cell Carcinoma 407 Wai-Kit Lee, M. Liza Lindenberg, Esther Mena Gonzalez, Peter Choyke, Kevin G. King, Raghunandan Vikram, Vinay A. Duddalwar Active Surveillance of Renal Cell Carcinoma 424 Eric C. Kauffman, Mark W. Ball, Ravi Barod, Umberto Capitanio, Antonio Finelli, M. Carmen Mir, Brian Shuch, Marc C. Smaldone, Maxine G.B. Tran, Phillip M. Pierorazio Ablative Therapies for Localized Primary Renal Cell Carcinoma 437 Muhammad Ali, Vanessa Acosta Ruiz, Sarah P. Psutka, David Liu, Shankar Siva Table of Contents http://SIUJ.org 362 SIUJ • Volume 3, Number 6 • November 2022 SIUJ.ORG Management of Locally Advanced Renal Cell Carcinoma 451 Vsevolod B. Matveev, Sarah P. Psutka, Grant D. Stewart, Gennady Bratslavsky, E. Jason Abel Neoadjuvant and Adjuvant Therapy for Renal Cell Carcinoma 465 Naomi B. Haas, Jeffrey Shevach, Ian D. Davis, Tim Eisen, Marine Gross-Goupil, Anil Kapoor, Viraj A. Master, Christopher Ryan, Manuela Schmidinger Therapies in Refractory Metastatic Renal Cell Carcinoma 478 Stephanie Berg, Martin Angel, Kathryn E. Beckermann, Frede Donskov, Chung-Han Lee, Pavlos Msaouel, Rana R. McKay, Tian Zhang Management of Toxicity and Side Effects of Systemic Therapy for Renal Cell Carcinoma 485 Kate Young, Andreas M. Schmitt, Deborah Mukherji, Lavinia Spain, Manuela Schmidinger, Lisa M. Pickering Clinical Picture Renal Cell Carcinoma With Intratumoral Pseudoaneurysm 501 Daniel P. Pierce, Elias H. Salloum, Philippe E. Spiess Table of Contents, Cont'd http://