SA JOURNAL OF PHYSIOTHERAPY 2002 VOL 58 NO 3 3 (Hoffmann et al 1994). Outcomes research has emerged from a growing concern about which medical treatments work best and for whom (Andersson & Weinstein 1994), and it is a focus of attention which the physiotherapy pro- fession needs to acknowledge and address. Outcomes research is an analysis of clinical practice as it actually occurs for the purpose of determining effec- tiveness of clinical methods (Domholdt 2000). This research is affordable, highly feasible in the clinical situation and has the potential to improve the quality of research into the clinical management of LBP. It would appear to be a valuable tool in determining the best use of limited resources for the management of a condition that places enormous demands on health-care budgets. Applied in the clinical situation, outcomes research has the potential to play a role in evaluating whether beneficial outcomes are due to physiotherapeutic interventions (Bardin 1998), or to time, chance or coincidental occurrences (Twomey 1990). Further- more, the results and conclusions from outcomes research are likely to contribute to further research questions, the for- mulation of hypotheses and the planning of randomised, controlled trials (RCT’s) ABSTRACT: Low back pain (LBP) is one of the most common and costly conditions treated by physiotherapists and is acknowledged as a major health problem. Much published research on LBP is of poor design and optimal outcome measures are not selected for LBP patients. Effective and cost-effective interventions for LBP, particularly chronic LBP, need to be identified using appropriate, valid, reliable and responsive measures of outcome. These outcome measures should reflect the biopsychosocial model necessary for evaluating the broad impact of LBP, in particular chronic LBP, on a patient’s life. Outcomes research is a feasible and affordable analysis of clinical practice as it occurs, and provides an opportunity to evaluate the effec- tiveness of interventions for LBP. This is in contrast to a randomised, controlled trial (RCT) that evaluates efficacy under controlled conditions that often do not reflect clinical practice. Using a battery of outcome measures appropriate for measuring change in the LBP population, outcomes research has the potential to identify effective and cost-effec- tive interventions, promote and influence further research, and contribute to the demand for evidence-based practice. KEY WORDS: LOW BACK PAIN, OUTCOMES RESEARCH, EVIDENCE-BASED PRACTICE, OUTCOME MEASURES, BIOPSYCHOSOCIAL MODEL, EFFECTIVENESS, EFFICACY PHYSIOTHERAPY AND LOW BACK PAIN - PART 1: OUTCOMES RESEARCH IN THE QUEST FOR EVIDENCE BARDIN LD, Cert. OMT (SA), M.Sc. (Physio.)1 1 Private practitioner, Park Orchards Physiotherapy and Ringwood Physiotherapy and Spinal clinic, Melbourne, Australia. CORRESPONDENCE TO: L Bardin Park Orchards Physiotherapy, 616 Park Road, Park Orchards, Melbourne, Victoria, 3114, Australia. Tel: 9-6-13-9876196 Fax: 9-6-13-98790711 E-mail: lynnbardin@yahoo.co.uk L I T E R A T U R E R E V I E W INTRODUCTION Low back pain (LBP) is the most common diagnosis for which patients are treated in outpatient physiotherapy settings (Jette and Davis 1991), and 70%-80% of people in Western society have at least one episode of LBP in a lifetime (Biering-Sorensen 1983). It is a well-known major health problem that causes the greatest disability in patients under the age of 45 years (Deyo 1983), as well as the greatest disability in role function (Jette and Jette 1996). With high prevalence and recurrence rates (Croft et al 1997; Taimela et al 1997), it has enormous implications for health- care. Furthermore, there appears to be an associated increase in chronic incapacity and up to 35% of those with LBP develop a chronic problem (Taimela et al 1997), which further adds to the burden of providers and purchasers of health-care. Thus LBP, in particular chronic/recurrent low back pain (CLBP), is a growing problem that places increasing demands on health budgets and has raised ques- tions about the validity of current treat- ments (Waddell 1998). Much of the published research on therapies for LBP is flawed by poor design and suboptimal outcome measures currently regarded as the gold standard of evidence and the only ‘scientific’ way of providing evidence of effective intervention and management (Mawson 2002). OUTCOMES RESEARCH AND EVIDENCE-BASED PRACTICE Although RCTs are regarded as the most robust form of evidence (Sackett et al. 1996), it has been suggested that they are not a universally attainable or even desirable gold standard of evidence in physiotherapy (Bithell 2000). They may also not be suitable for rehabilitation (Mawson 2002), which is highly relevant in the approach to management of CLBP (Bardin 1998 and 2000b). The Research Committee (Victorian Branch) of the Australian Physiotherapy Asso- ciation (1999) recently advocated that 4 SA JOURNAL OF PHYSIOTHERAPY 2002 VOL 58 NO 3 the use of evidence concerning efficacy derived under the restricted, experi- mental conditions of a RCT requires clinical skill, judgement and experience for application to individual patients. Because of the large number of variables that can impact on a clinical intervention, the RCT may not always be the best methodology for evaluating the efficacy of many of the modalities and multi- modalities used in clinical practice (Moore and Petty 2001). It has been suggested that within the chronological growth of the health professions, evi- dence-based practice is still in it’s infancy (Moore and Petty 2001). The RCT is at the top of the hierarchy of evidence, which ranges from clinical experience up to systematic review of RCTs (Fig.1). It has further been sug- gested that there is a paradox regarding the RCT. It is recognised as the best way to assess whether an intervention works, but is arguably the worst way to assess who will benefit from it (Mant 1999). Few RCTs exist in the evaluation of orthopaedic procedures as ethical and practical issues limit the possibility of randomisation. Outcomes research is an alternative clinical investigation where the balance of rigour and relevance is more easily attained. Liang et al (1994) defined outcomes research as research on the management of patients that asks what treatment is effective, and for whom, in more realistic settings than ones used in RCTs. Outcomes research provides a feasible analysis of clinical practice as it occurs (Bardin 2000a). Domholdt (2000) suggests that research questions should arise from problems experienced in the clinical practice of physiotherapy. Outcomes research can be conducted in everyday clinical phy- siotherapy settings and, prospectively planned, is well suited to raise and explore various aspects of clinical research that can contribute to the body of evidence from grade V to III levels (Fig. 1). In the quest for credibility of the value of treatment for LBP, the role of outcomes research should be considered, possibly as a forerunner to develop research questions, to test hypotheses and to refine aspects of the research process. Preliminary research using the outcomes research model should have the potential to improve the quality of research implemented in RCTs, which are often difficult and expensive to conduct. In spite of difficulties in the application of the evidence of efficacy (Australian Physiotherapy Association, Victorian Branch 1999) and of to whom to apply treatment, the RCT is likely to continue to be acknowledged as the highest level of evidence. For this reason it is of cardinal importance that future protocols for this rigorous research are based on appropriate preliminary research, of which outcomes research is one example. It would appear that outcomes research has a significant role to play in our endeavours to refine the quality of scientific inquiry into the effective management of LBP. MEASURING THE OUTCOME AND ASSESSING EFFECTIVENESS Physiotherapists need to adopt outcome measures that will document effective- ness of interventions and guide clinical decisions and management. In outcomes research effectiveness is the usefulness of a particular treatment to the indivi- dual(s) receiving it, under typical cli- nical conditions usually determined by nonexperimental methods (Domholdt 2000). In contrast, clinical efficacy is the biological effect of treatment under carefully controlled conditions, usually determined by RCT. Measuring the effectiveness of our treatments is vital to the survival of the physiotherapy pro- fession and to satisfy the demands for evidence-based practice. It is only pos- sible if we measure change by careful documentation of the outcome of care provided in clinical practice. Although it has been suggested that evidence-based physiotherapy is possibly seeking the unattainable (Clemence 1998), the pur- suit of best evidence is of paramount importance to our future credibility. It is not optional if the profession is to compete in the health-care arena for the provision of evidence-based treatments In cr ea si ng s tr en gt h of ev id en ce Strong evidence from systematic review of multiple RCTs Strong evidence from RCT of appropriate size Evidence from well-designed trials without randomisation Well-designed non-experimental studies from more than 1 centre Opinions of respected authorities, based on clinical evidence, descriptive studies or reports of expert committees I II III IV V Figure 1: Hierarchy of evidence ranging from clinical experience up to systematic review of RCTs. A broad contribution from levels V - III is possible through outcomes research. (Modified from Moore and Petty 2001) SA JOURNAL OF PHYSIOTHERAPY 2002 VOL 58 NO 3 5 for LBP. Outcomes research using appro- priate outcome measures in a typical clinical setting is attainable, affordable and should provide a measure of evi- dence. It will undoubtedly emphasise accountability for standards of care and selection of treatment intervention, and is likely to promote and influence fur- ther research. What is an outcome measure? Broadly speaking, an outcome measure quantifies a change in the patient’s status over time (Kane 1994), and makes it possible to examine the end results of health-care and the effects of the health care process on the well-being of either individual patients or whole populations (Andersson and Weinstein 1994). It has also been described as a measure of change, the difference from one point in time (usually before an intervention) to another point in time (usually following an intervention) (Kendall 1997). Mayo et al (1994) further specify a physiothe- rapy outcome measure as a test or scale, administered and interpreted by physiotherapists, that has been shown to measure accurately a particular attribute of interest to patients and therapists and is expected to be influenced by the intervention. Purpose of outcome measures The physiotherapy profession is being challenged to record the outcome of care provided to patients. The purpose of using outcome measures is an attempt to define closely the subjective and objective information we usually record, but in a more robust manner (Hammond 2000). This can be achieved by the use of appropriate and valid outcome mea- sures which, by providing reliable docu- mentation, will guide clinical decisions, treatment planning and prove effective- ness of interventions in a clinical setting (Bardin 1998). Measuring outcomes enables the clinician to determine: • The impact of an overall treatment on an individual • The impact of a specific treatment approach on an individual • The overall impact of care on all clients within a programme • Productivity - i.e. the relationship between resources used and treatment outcomes is assessed in order to eva- luate the effectiveness and efficiency of the service provided It has been suggested that, in order to assess progress in patient management, important outcomes to measure are those of pain relief and disability (Liebenson and Yeomans 1997). Reduction in LBP, improvement in function and prevention of disability are core aspects of physio- therapy management of LBP. It is impor- tant for the credibility of our management approach to LBP that we measure the effect of our treatments on these outcomes. Selection of outcome measures Outcome measures should be clinically appropriate, functionally relevant, valid, reliable and responsive to clinical change (Schoppink et al 1996; Bardin 1997; Bardin 1998). Pain scales useful in the clinical situation, for example, are the Numerical Rating Scale, Visual Analogue Scale and McGill Pain Questionnaires (MPQ) (long- and short-forms) (Jensen et al 1986; Melzack 1975). The Roland Morris Disability Questionnaire (Roland and Morris 1983), Aberdeen Back Pain Scale (Ruta et al 1994) and Oswestry Disability Questionnaire (Fairbank et al 1980) for pain and functional impair- ment/disability, and the condition- specific functional status questionnaire for lumbar spinal stenosis (Stucki et al 1996) are examples of questionnaires measuring the broad biopsychosocial impact of interventions for LBP. Bouter et al (1998) suggest that researchers identify the factors to be measured and measure them with high-quality, stan- dardised parameters with explicit instruc- tions for administration and scoring. This will enable practitioners to make comparisons about the health status of patients at the end of their intervention. Several authors suggest that outcome measures need to be inexpensive and time-efficient to minimize the burden to health professionals and patients (Liebenson and Yeomans 1997; Deyo et al 1998; Wright et al 1998), while Hammond (2000) is of the opinion that in order to be acceptable to patients they should be comfortable and painless. A spectrum of outcomes measures reflecting the biopsychosocial model will be reviewed in Physiotherapy and low back pain: Parts II and III. OUTCOMES RESEARCH IN THE ASSESSMENT OF THE QUALITY OF HEALTH CARE Outcomes research is a focus of atten- tion on the assessment of health-care quality that the physiotherapy profes- sion needs to acknowledge and address. It has emerged from a growing concern about which medical treatments work best and for whom (Andersson and Weinstein 1994), and will assist analysis of the relative effectiveness and cost- effectiveness of different interventions for LBP. Furthermore it should facilitate physiotherapists to identify subgroups to be treated (Bardin 1998 and 2000c; O’Sullivan 2000), and to provide pur- chasers of health-care with evidence of effectiveness (Chesson et al 1996; Watson 1999). Health-care consumers want evidence of effectiveness when choosing what to purchase. In the context of cost contain- ment, there is a need to analyse the rela- tive effectiveness of different interventions especially for recurrent/chronic LBP (Bardin 1998 and 2000b). Outcomes research will facilitate the practice of outcomes management which relies on an analysis of outcomes to examine the cost and quality of health- care. These two inter-related issues are of great interest to clinicians as well as to government health departments, insurance departments, insurance compa- nies and consumers. Outcomes manage- ment offers great potential for identifying client needs, improving outcomes, utilis- ing evidence-based treatments and allo- cating scarce resources (Hazard 1995; Mayer et al 1995; Bardin 1998), and is considered a crucial component in pro- moting quality without sacrificing cost. Outcomes research, as defined by Liang et al (1994), focuses on investi- gating what treatments are effective in realistic clinical settings (in contrast to RCTs) and for which groups of patients. These researchers suggest that the emphasis should be on the patient’s assessment of pain, function, quality of life and satisfaction with the results of the intervention. Outcomes research can be described as research that evaluates the broad biopsychosocial impact of 6 SA JOURNAL OF PHYSIOTHERAPY 2002 VOL 58 NO 3 treatments implemented in typical clinical settings (Keller et al 1994; Bradham 1994; Bardin 2000a). This is in sharp contrast to a clinical efficacy study where the biological effect of treatment is monitored under the carefully con- trolled conditions possible with labora- tory research. A recent study by Bardin (1998 and 2000b) is an example of out- comes research. This research included inter alia patients’ assessments, as sug- gested by Liang et al (1994), to evaluate the effectiveness of a spinal rehabilitation programme utilising patient education and group exercises for the treatment of selected patients with chronic/recurrent LBP. Results from this study showed significant reduction in pain and handi- cap, as well as significant improvement in function and flexibility following patient participation over a one-month period. Importantly, these improvements in outcomes were significantly main- tained at the three and six month follow- ups and there was an exceptionally high (91%) level of patient satisfaction with this cost-effective approach to the management of CLBP. Domholdt (2000) suggests that in outcomes research prac- titioners and researchers supplement measures of pathology and impairment with person-level measures of functional limitation, disability or handicap. This type of research is feasible in most clini- cal situations and is necessary to deter- mine a valid approach to the manage- ment of LBP, particularly CLBP. In a study on the outcome of 438 patients treated surgically for lumbar spinal stenosis, the authors acknowledged that the most important shortcoming of their study was that the initial levels of the patients’ pain, depression and disability were not known (Olavi et al 1997). This acknowledged shortcoming illustrates that prospectively planned documen- tation of outcomes is essential if we are to gather even lower levels of evidence, without which the higher levels may not achieve an appropriate focus of inquiry. Outcomes research is a feasible, affordable analysis of the outcome of health-care that utilises measures reflect- ing the biopsychosocial model necessary for evaluating the impact of LBP, in particular CLBP, on a patient’s life. Outcome measures that reflect the bio- psychosocial model are important to evaluate change in LBP patients (Bardin 1998; Cherkin 1998; Deyo et al 1998) as objective outcome measures related to the biological component have been found to be only weakly correlated with patient behaviour or symptoms. Health related quality of life measures, which assess multiple dimensions of life, are thought to be an inexpensive, valuable source of quantitative data for quality assurance and research of the CLBP patient. The physiotherapy profession should respond positively to the challenge of analysing the quality of our care for acute and chronic LBP patients. Outcomes research is feasible and affordable. It should be enthusiastically embraced as an opportunity to demonstrate our scien- tific foundations, to promote quality of care and to provide a necessary and valuable contribution to our quest for evidence-based practice. CONCLUSION The high prevalence, recurrence rates and enormous cost to society of LBP, particularly CLBP, places a responsibi- lity on the physiotherapy profession to provide evidence for management approaches to LBP patients and for effectiveness of interventions. In the quest for evidence, physiotherapists can utilise outcomes research - an analysis of clinical practice that focuses on patients’ assessments of pain, function, quality of life and satisfaction with the results of the intervention. Prospectively planned documentation of outcomes using valid, reliable and responsive out- come measures is necessary to provide evidence of effectiveness, and to con- tribute to further research in the field of LBP. These outcome measures should be clinically appropriate, functionally relevant and reflect the broad biopsy- chosocial impact occurring in the LBP patient as a result of this disabling con- dition. The RCT, conducted under con- trolled conditions, is the highest form of evidence, however treatment under these conditions often does not reflect clinical practice and the application of evidence may be difficult. The role of outcomes research to assess health-care, to evaluate effectiveness and cost-effec- tiveness, and to promote further research and scientific inquiry should be consid- ered. It is a feasible and affordable option to complement RCTs in the demand for evidence-based practice. 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