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Kcentra® (Prothrombin Complex Concentrate [Human]): Its indications, side effects, and contraindications

Amr Ismail MD

ABSTRACT

Patients with a high risk for thromboembolic events can be on long-term warfarin. These patients need close monitoring of their INR and for signs of bleeding. Conventionally, fresh frozen plasma (FFP) is used for reversal of INR in patients with major bleeding or who need urgent surgery or invasive procedures. Kcentra is now available as an alternative to FFP for rapid reversal of INR and urgent hemostasis.

Keywords: Kcentra, four factor prothrombin complex concentrate, acute major bleeding, urgent hemostasis, INR reversal, warfarin




Article citation: Ismail A. Kcentra® (Prothrombin Complex Concentrate [Human]): its indications, side effects, and contraindications. Southwest Respiratory and Critical Care Chronicles 2017;5(21):11–15

From: Department of Internal Medicine at Texas Tech University Health Sciences Center, Lubbock, Texas

Submitted: 4/6/2017

Accepted: 10/4/2017

Reviewer: Catherine Jones MD

Conflicts of interest: none