Case report Recurrences of giant cell tumor of bone within soft tissue Dylan Homen MD, George Brindley MD, Cody Beaver MD ABSTRACT Giant cell tumor of bone (GCTB) is typically considered an aggressive but benign tumor, and recurrence of the tumor following surgical intervention is common. It is much rarer, however, for recurrence to occur in the soft tissue surrounding the original lesion. Literature investigating recurrent giant cell tumor of soft tissue is much more limited than literature on bony recurrence, and our understanding of its etiology is still developing. This report reviews two cases in which recurrence of the tumor occurred in the adjacent soft tissue following intralesional excision of GCTB; our aim is to identify variables that could have contributed to this atypical recurrence and to stimulate more investigations into methods for possible prevention. Keywords: giant cell tumor, bone, soft tissue, recurrence Article citation: Homen D, Brindley G, Beaver C. Recurrences of giant cell tumor of bone within soft tissue. The Southwest Respiratory and Critical Care Chronicles 2020;8(34):56–60 From: Department of Orthopedics, Texas Tech University Health Sciences Center, Lubbock, Texas Submitted: 2/23/2020 Accepted: 4/15/2020 Reviewer: Chok Limsuwat MD Conflicts of interest: none This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.