Case series A tale of two SCADs: Spontaneous coronary artery dissection series Sanjana Rao BS, Nitish Mittal BS, Mohammad M Ansari MD ABSTRACT Spontaneous coronary artery dissection (SCAD), a relatively rare condition, occurs when a tear develops in the coronary artery wall that may slow blood flow and lead to clot formation. This occurs mostly in relatively young and healthy women with minimal past medical histories; most patients have chest pain or shortness of breath. In this report, we present two female SCAD patients and discuss the etiology, diagnosis, and treatment of SCAD. We describe a 33-year-old woman and a 40-year-old woman, both presenting to the emergency department with chest pain and shortness of breath. Coronary artery angiography demonstrated SCAD. Both patients were treated with aspirin, beta-blockers, and statins with good clinical responses; one patient required a coronary stent. Keywords: Spontaneous coronary artery dissection, female, intramural hematoma Article citation: Rao S, Mittal N, Ansari MM. A tale of two SCADs: spontaneous coronary artery dissection series. The Southwest Respiratory and Critical Care Chronicles 2021;9(37):70–73 From: Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas Submitted: 12/16/2021 Accepted: 1/8/2021 Reviewer: Deephak Swaminath MD Conflicts of interest: none This work is licensed under a Creative Commons Attribution-Share Alike 4.0 International License.