  Thyrotoxicosis in pregnancy: A case report *Bola R Kamath1, Kamla J Rao1, Adikari AK Mayadunne2 ABSTRAC T. There are various causes of hyperthyroidism in pregnancy such as Graves’ disease and gestational thyrotoxicosis. The thyroid stimulation results from the excessive levels of circulating human chorionic gonadotropin (hCG) produced by the trophoblastic tissue in both hydatidiform moles and choriocarcinoma. We present a pregnant patient with hydatidiform mole who presented with hyper- thyroidism that resolved after evacuation of the mole. Keywords: thyrotoxicosis, hydatidiform mole, pregnancy, hCG 1Department of Medicine and 2Obstetrics & Gynæcology, Armed Forces Hospital, P.O.Box , Postal Code , Seeb, Sultanate of Oman. *To whom correspondence should be addressed. E-mail: rajkamat@omantel.net.om T     -nancy is reported in the range of .–.. e majority of the patients have Graves’ disease while other causes of hyperthyroidism occur much less fre- quently. Data accumulated indicate that human chorionic gonadotropin (hCG) has weak thyroid stimulating activity. Besides its contribution to hyperthyroidism in patients with trophoblastic tumours, the clinical significance of the thyrotrophic action of hCG is now also recognized in nor- mal pregnancy and hyperemesis gravidarum.1 T H E C A S E A -year-old -weeks pregnant woman was admitted to the Armed Forces Hospital on June ,  with history of abdominal pain, vomiting and bleeding per vagina, as well as the history of two previous missed abortions. Clinical examination showed she had tachycardia (/min). No goitre was seen. Otherwise the vital signs were stable. Pelvic scan was suggestive of molar pregnancy with bilat- eral ovarian theca lutial cyst. Liver enzymes were raised. Serum BhCG was , mIU/l. yroid function test (TFT) showed FT > pmol/l and TSH . uIU/ml. ECG showed sinus tachycardia. She was treated with propranolol  mg , neomercazole  mg , Lugol’s Iodine . ml , and supportive care. Nine days aer admission, she had an incomplete abortion aer which an evacuation of retained product of conception (ERPC) �������������������������������������������������������� �������������� � � ������ �������� ����� ��������� ���� ��������� ����� �������� ������������� ���� ������ �������� ��������� �������� �������� ��� ��� ��� �������� ��������� ����� ��� ������ �������� �������� ��� ��� ��� ��������� ������ ������ ��� ������ �������� ������ ����� ����� ������ �������� � ����� ����� ����� ���������������������������������������������������������������������������� ������������������������������������������������� � ������������������������������������������������ � ������������������������� ������������������������ ������������������ ��������������������� ��������������������� ������������ ��������������� ��������������������������������� ����������� ������������������ ������������������������ ����������������������������� ������� ������������������������ �������������������������������� �������������������� �������������� ����������������� � ����������������� � � �     :   , : , : , – ©   Thyrotoxicosis in pregnancy ����� �� ������ ������: ���� ����� ������ ���� � ��� ���� ����� ��� ������:������ ������ � ����� ��� ��� ����� ����� ������� ���� ����� ����� ��������� ���� .������ �� ������� ����� ����� ���� ��������� ��������� �������� ����� �� �� �� ������� ������ ����� �� ������ � ���� �� ���������� ����� ����� ����� .��� ���� ��� ���� � �������� ������ ����� ���� ����� ������ ������� ������� ����� �� ���������� ����� ��� ������ ��� ���� ��.   was performed. Histopathology of the endometrium con- firmed hydatidiform mole. e anti-thyroid medications were stopped. All the features of hyperthyroidism resolved when the hydatidiform mole was evacuated. A repeat TFT two weeks later showed results within normal limits, and the BhCG level dropped down to . mIU/l. When the patient was reviewed  months later, she remained asymp- tomatic and a repeat TFT was normal. D I S C U S S I O N Graves’ disease is the commonest cause of hyperthyroidism in pregnancy while other causes occur much less frequently [Table ].11 In patients with hyperthyroidism caused by tropho- blastic tumours, serum hCG levels usually exceed  U/ ml. However, thyrotrophic potency of hCG varies among its different isoforms, which explains why some patients with trophoblastic tumours and very high serum hCG levels do not manifest hyperthyroidism.4 Both hCG and thyroid stimulating hormone (TSH) are glycoproteins, which are composed of a common alpha-subunit and a non-covalently linked hormone-specific beta-subunit. is structural homology suggests the basis for cross-reactivity of hCG with the TSH receptor.3 e diagnosis of hyper- thyroidism is established by finding elevated serum free T and T levels, and suppressed TSH concentration. In most instances, a patient with molar pregnancy has mild hyper- thyroidism with a small goitre, and the hyperthyroidism resolves rapidly aer surgical removal of the hydatidiform mole. Conversely, patients with choriocarcinoma who manifest hyperthyroidism usually have a large mass, and antithyroid therapy may be required in addition to chemo- therapy for the tumour.5 e term gestational thyrotoxicosis refers to a subset of hyperemetic patients with clinical and biochemical hyperthyroidism in early pregnancy.1 It is believed to result from circulating hCG with high biological activ- ity. It usually resolves spontaneously in the latter half of pregnancy. Women with gestational thyrotoxicosis may be differentiated from those with Graves’ disease by the absence of goitre and negative antithyroid antibodies whose titre decreases from mid trimester onwards. As gestational thyrotoxicosis is mediated by hCG, no thyroid antibodies should be present. Hyperthyroidism is transient and self-limiting in this condition, and specific antithyroid treatment is not required. Hyperemesis gravidarum occurs in about – of pregnancies and most investigators believe in the putative role of hCG in cases of hyperemesis and hyperthyroidism. Circulating free T and free T levels were frequently elevated in hyperemetic patients suggesting a relationship between the severity of the hyperemesis and the biochemi- cal evidence of hyperthyroidism. However, the hCG levels in women with hyperemesis compared to those without emesis are similar, but the former have increased serum thyroid stimulating activity. Kimura et al hypothesized that the hyperemetic patients produce molecular variants of hCG with increased thyroid stimulating activity.1 Graves’ disease oen remits in mid-trimester and recurs aer delivery. If untreated, this condition can lead to signif- icant morbidity and mortality in both mother and fetus. Beta blockers are effective in controlling hypermeta- bolic symptoms and may be used in combination with thionamides until the symptoms abate. Propylthiouracil and carbimazole are similarly effective in (blocking thy- roid hormone synthesis.7 Propylthiouracil appears to have some advantage over carbimazole as it inhibits the peripheral conversion of T to T, crosses the placenta less than methimazole does and is less readily secreted in breast milk. ey should be administered in the lowest possible dose to target maternal serum free T concentra- tion in the upper limits of normal as both the drugs can cross the placenta and can cause fetal goitre and hypothy- roidism. Block-replacement regimen is contraindicated in pregnancy because thyroxine crosses the placenta less well than carbimazole and foetal goitre and hypothyroidism may result and the mother must also be given more methi- mazole if maternal hyperthyroidism is to be prevented. Further, the rare congenital abnormality of congenital aplasia cutis congenita may be associated with the use of methimazole in pregnancy. Dosage of thionamides should be reduced progressively in anticipation of the usual steady amelioration in the disease as pregnancy advances and treatment can eventually be discontinued in approximately  of patients.6 Surgery is reserved for patients who are �������������������������������������������������������� �������������� � � ������ �������� ����� ��������� ���� ��������� ����� �������� ������������� ���� ������ �������� ��������� �������� �������� ��� ��� ��� �������� ��������� ����� ��� ������ �������� �������� ��� ��� ��� ��������� ������ ������ ��� ������ �������� ������ ����� ����� ������ �������� � ����� ����� ����� ���������������������������������������������������������������������������� ������������������������������������������������� � ������������������������������������������������ � ������������������������� ������������������������ ������������������ ��������������������� ��������������������� ������������ ��������������� ��������������������������������� ����������� ������������������ ������������������������ ����������������������������� ������� ������������������������ �������������������������������� �������������������� �������������� ����������������� � ����������������� � � �            not responding to antithyroid drugs because of non-com- pliance or allergy to both the drugs. yroidectomy can be safely performed in the second trimester. Radioactive iodine therapy is contraindicated in pregnancy because of potential congenital malformations or congenital hypothy- roidism.8 Hyperthyroid pregnant patients should be seen at –weeks intervals, with a collaborative effort between the treating physician and obstetrician. yroid-stimulating immunoglobulin (TSI) titres obtained in the last trimester may predict the likelihood of neonatal hyperthyroidism. Any newborn from a mother who has a history of hyper- thyroidism should be observed for this possibility, due to the transplacental transfer of TSI. e earliest clinical sign of fetal thyrotoxicosis is fetal tachycardia [>/min]. Serum thyroid stimulating hormone and yroxine con- centration should be measured in neonates whose mothers have or have ever had Grave’s disease. Postpartum thyroiditis (PPT) is an autoimmune condi- tion that occurs in approximately  of women during the first year of postpartum. e well-recognized improvement in clinically overt and biochemically proven autoimmune thyroid disease in pregnancy is due to the state of relative immune suppression in the mother. is is character- ized by a rebound in antibody activity in the postpartum period. is is frequently associated with hyperthyroid phase occurring in the first  months of postpartum, fol- lowed by hypothyroid phase between  to  months aer delivery with spontaneous recovery in the majority of patients.9 yrotoxocosis in postpartum thyroiditis (PPT) is usually mild and self-limiting (–weeks duration) and is distinguished from Grave’s disease by a low Radio Active Iodine Uptake[RAIU] (study contraindicated if the mother is breast-feeding). Beta-blockers can be administered if symptoms are severe. Antithyroid drugs are not useful in PPT because thyrotoxicosis is secondary to hormone release from the damaged gland9. e importance of rec- ognition of this syndrome is two fold: (i) a clear associa- tion has been established between the development of this syndrome and alteration in the mood and behaviour that occurs during postpartum period. (ii) ere is clear evi- dence that in a significant number of women the transient syndrome may go onto permanent hypothyroidism.10 C O N C L U S I O N yroid problem is the most common pre-existing endocrine disorder during pregnancy reflecting in part a predilection for thyroid problems in women of child- bearing age. Maternal thyrotoxicosis occurs about once in every  pregnancies, and the diagnosis may be difficult because the increase in cardiac output, tachycardia, skin warmth and heat intolerance typical of pregnancy can mimic hyperthyroidism. e diagnosis of thyroid disease is complicated by many important physiological changes in thyroid metabolism and laboratory values observed in pregnancy. Measurement of TSAb concentration in women with active Grave’s disease in late pregnancy or with previous ablative therapy for Graves’ disease is useful to predict neonatal Graves’ disease. Also, systemic thyroid autoantibody screening in the early stages of gestation may improve obstetric outcome and identify women at risk of PPT. Proper understanding of all this is essential for the effective management of thyroid disease in pregnancy.              We thank the Director of Medical Services, Forced Medical Services, Royal Army of Oman, for the permission to pub- lish this case report . 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