According to the World Health Organization, the annual tuberculosis (TB) burden in India was 2.2 million in 2012; this figure constitutes one quarter of global TB cases per year.1 Genitourinary TB is a common form of extrapulmonary TB, accounting for 27% (range: 14–41%) of all cases of extrapulmonary TB in developed countries.2 Usually, genitourinary TB is a complication in 3–4% of pulmonary TB cases.3 Active genitourinary TB generally occurs between five and 15 years after a primary pulmonary infection with Mycobacterium tuberculosis.4 Despite its status as the most common form of genitourinary TB, renal TB is very rare in the paediatric population.5 Genitourinary TB mostly presents with irritative voiding symptoms, haematuria and flank pain.6 Presentation as a mass lesion is extremely rare and few cases have been published in the literature to date.7–10 This report describes a two-year-old child who presented with a renal mass and was diagnosed with renal TB via a post-nephroureterectomy histo- pathological examination. Case Report A two-year-old girl presented to a private health clinic in Kolkata, India, with non-specific abdominal pain of three months’ duration. As she did not improve with symptomatic management and anthelmintic therapy, she was referred to the Nil Ratan Sircar Medical College, Kolkata, India, in June 2014 for further evaluation. There was no history of fever, vomiting, altered bowel habits, abdominal distension or changes in urinary frequency or colour over the preceding three months. In addition, no appetite or weight loss had been observed by the parents. The child Departments of 1Chest Medicine and 2Pathology, Nil Ratan Sircar Medical College, Kolkata, India *Corresponding Author e-mail: dravradip@gmail.com ظهور السل الكلوي كآفة كتلة يف طفلة عمرها سنتان عرض حلالة نادرة اأفراديب �شنرتا، فالجوين مندي، اأبهي�شك ب�ندى اأوب�دي� abstract: Genitourinary tuberculosis usually occurs in young adults and the middle-aged and is very uncommon in the paediatric population. It generally presents with haematuria, pyuria, irritative voiding symptoms and flank pain; presentation as a renal mass is highly unusual. We report a two-year-old girl who was referred to the Nil Ratan Sircar Medical College, Kolkata, India, in June 2014 with abdominal pain. Subsequent radiological investigations revealed a left renal hypoechoic mass lesion. A left nephroureterectomy was performed on suspicion of a Wilms’ tumour. Histopathology indicated an epithelioid granuloma with lymphocytic infiltration, suggestive of a tubercular aetiology. A Mantoux tuberculin skin test was positive; however, there was no evidence of tuberculosis detected elsewhere in the body and the source of the infection could not be identified. A diagnosis of renal tuberculosis was made and the child was treated with antitubercular drugs. The patient was asymptomatic at a six-month follow-up. Keywords: Renal Tuberculosis; Urogenital Tuberculosis; Abdominal Pain; Granuloma; Case Report; India. امللخ�ص: ال�شل البويل التن��شلي يظهر ع�دة عند ال�شب�ب ومتو�شطى العمر وهو ن�در احلدوث عند االأطف�ل. وع�دة م� يظهرمع وجود بيلة دموية، بيلة قيحية، اأعرا�ص تهيج عند االأ�شتفراغ واأمل اخل��رضة، لكن الظهور ككتلة كلوية يعترب غري ع�دي للغ�ية. نعر�ص هن� تقرير ح�لة الفحو�ش�ت معوي. ب�أمل م�ش�بة ،2014 يونيو يف ب�لهند كلكت� يف للطب �شريك�ر رات�ن نيل كلية اإىل حتويله� مت �شنت�ن عمره� لطفلة اإل�شع�عية اأظهرت وجود كتلة آفة ن�ق�شة ال�شدى. مت ا�شت�ش�ل الكلية الي�رضى مع احل�لب وذلك ال�شتب�ه وجود ورم وملز. تقرير الت�رضيح املر�شي بني وجود حبيب ب�رضاين مع ارت�ش�ح ملف�وي يوحى مب�شبب�ت مر�شية لل�شل. ك�ن فح�ص م�نتو �شلني للجلد اإيج�بيا، لكن مل يتم العثور على وجود لل�شل يف االأجزاء االأخرى من اجل�شم وكذلك عدم التمكن من العثور على م�شدر االألته�ب. مت ت�شخي�ص احل�لة ب�ل�شل الكلوي ومت عالج الطفلة مب�ش�دات ال�شل.وك�نت الطفلة خ�لية من االأعرا�ص عند املت�بعة بعد 6 اأ�شهر. مفتاح الكلمات: ال�شل الكلوي؛ ال�شل البويل التن��شلي؛ اأمل البطن؛ حبيب؛ تقرير ح�لة؛ الهند. Renal Tuberculosis Presenting as a Mass Lesion in a Two-year-old Girl Report of a rare case *Avradip Santra,1 Falguni Mandi,1 Abhishek Bandyopadhyay2 case report Sultan Qaboos University Med J, February 2016, Vol. 16, Iss. 1, pp. e105–108, Epub. 2 Feb 16 Submitted 20 Jul 15 Revision Req. 26 Aug 15; Revision Recd. 4 Sep 15 Accepted 17 Sep 15 doi: 10.18295/squmj.2016.16.01.020 Renal Tuberculosis Presenting as a Mass Lesion in a Two-year-old Girl Report of a rare case e106 | SQU Medical Journal, February 2016, Volume 16, Issue 1 however, her chest X-ray was normal and a gastric lavage was negative for M. tuberculosis. Morning urine samples taken on three consecutive days were AFB-negative and a urine culture was also negative for M. tuberculosis. There was no evidence of active TB on chest X-rays or AFB in sputum examinations for any of the patient’s family members. An endometrial biopsy was requested from the child’s mother; however, this was not performed as she was completely asymptomatic and did not give consent for the investigation. The patient was diagnosed with renal TB based on the findings of the renal histopathology and ancillary investigations. She subsequently underwent two months of intensive phase antitubercular therapy with isoniazid, rifampicin, pyrazinamide and ethambutol, followed by four months of continuation phase therapy with isoniazid and rifampicin, as per the guidelines of the Revised National Tuberculosis Control Programme (RNTCP).11 She improved symptom- atically and the abdominal pain subsided within one month of beginning the treatment. By the end of the six-month antitubercular therapy, she was completely asymptomatic. At the time of writing, the patient was being followed up at regular intervals. Discussion Genitourinary TB is most commonly encountered between the second and fourth decade of life.3,6 This form of TB represents less than 5% of paediatric extrapulmonary cases worldwide and is very infrequently reported in the literature.12,13 Chattopadhyay et al. observed only nine cases of paediatric genitourinary TB over a span of seven years among patients aged 5–12 years old.14 A case of congenital renal TB was reported in a 34-day-old infant presenting with exsanguinating haematuria.13 Another report described miliary TB with focal had been delivered at full term at home and was not immunised. She had no prior significant illnesses and her developmental history was normal. There were no signs of pallor, icterus, palpable lymphadenopathy or malnutrition. An abdominal examination revealed no palpable organomegaly or tenderness. The results of routine biochemical tests and a complete haemogram were within normal ranges and the child was negative for human immunodeficiency virus infection. Ultrasonography of the abdomen revealed a hypo- echoic mass lesion in the left kidney along with mild hepatomegaly without any abdominal lymphaden- opathy, splenomegaly or ascites. Subsequently, a com- puted tomography scan of the abdomen was performed with intravenous and oral contrast. A well-defined hypodense space-occupying lesion (28 x 23 x 32 mm) with heterogeneous enhancement was observed at the mid-pole of the left kidney compressing the left renal pelvis [Figure 1]. No other abnormalities were observed. The liver was mildly enlarged, but otherwise normal in terms of position, shape and contour. The intrahepatic biliary radicles were also normal. These findings were suggestive of a Wilms’ tumour and a left nephroureterectomy was deemed necessary. Following the surgery, a histopathological exam- ination of the excised mass revealed granulomatous interstitial nephritis with central areas of caseous necrosis. An epithelioid granuloma was observed along with Langhans giant cells and dense lymphoplasmacytic infiltrate with lymphoid follicle formation. The granuloma was found within the perinephric fat [Figure 2]; however no evidence of acid-fast bacilli (AFB) was found with Ziehl-Neelsen staining. A Mantoux tuberculin skin test using two tuberculin units of purified protein derivative RT-23 was positive with an induration of 12 mm. The patient underwent further evaluations for congenital TB; Figure 1: Contrast-enhanced abdominal computed tomography scan showing a well-defined hypodense mass lesion in the left kidney of a two-year-old girl with renal tuberculosis. Figure 2: Haematoxylin and eosin stain at x10 magnification showing a caseating epithelioid granuloma and lymphoid follicle within the perinephric fat of a two-year-old girl with renal tuberculosis. Avradip Santra, Falguni Mandi and Abhishek Bandyopadhyay Case Report | e107 renal involvement in a five-month old male infant.15 Commonly, patients with renal TB present with dysuria, haematuria, sterile pyuria, flank pain, recurrent urinary tract infections and constitutional symptoms.6,13 However, the radiographic appearance of the condition is variable and depends on the stage of infection.16 An enhancing renal mass is a rare presentation; in such cases, renal cell carcinomas, renal metastasis, lymphomas or abscesses are usually considered in the differential diagnosis.17 Similarly to the present case, Dhua et al. noted a well-defined hypodense renal mass in a case of renal TB.13 Kumar et al. reported a pseudotumoural manifestation of genitourinary TB in a 34-year-old woman, which was initially suspected to be a renal cell carcinoma.7 A solid tubercular large mass mimicking a tumour in a horseshoe kidney has also been described in the literature.8 Haematogenous dissemination from an active TB infection site usually results in the formation of metastatic tubercles in the kidney which either heal spontaneously or as a result of antitubercular therapy. Renal lesions may sometimes progress during primary infection or enlarge after several years.3 In the current case, the route of infection could not be ascertained. There was no evidence of active TB elsewhere in the body or among family members. Additionally, the case did not meet the revised criteria for a diagnosis of congenital TB as described by Cantwell et al.18 Nevertheless, it is often very difficult to differentiate congenital TB from acquired neonatal TB when the baby is infected after birth. Unfortunately, a maternal endometrial biopsy could not be performed to rule out this possible source of infection. Renal TB can be cured without surgical inter- vention; however, this requires timely diagnosis and a high degree of clinical suspicion.6 Unfortunately, the tubercular aetiology of the tumour-like mass in the current case was not suspected preoperatively and early radical surgery was performed. Fine-needle aspiration cytology (FNAC) is a recommended diagnostic procedure to avoid surgical intervention and retain the affected kidney.7 Additionally, the interferon gamma release assay (IGRA) test, which can detect M. tuberculosis infection anywhere in the body, is generally considered a more effective diagnostic tool than a conventional tuberculin skin test.19 However, this test was not carried out in the present case due to a lack of IGRA performance data in paediatric populations below five years of age.19 In addition, certain nontuberculous mycobacteria—including M. kansasii, M. szulgai and M. marinum—may produce false-positive results which could complicate the diagnostic procedure.19 Short-course chemotherapy is the standard pharmacological treatment for genitourinary TB, as per the RNTCP guidelines.1,2 A six-month course of category I therapy can be highly efficacious; Singh et al. described positive urinary AFB, mycobacterial cultures or polymerase chain reaction tests in 86.4% of genitourinary TB cases which became negative within three months of antitubercular therapy.6 Nevertheless, surgery still plays an important role in genitourinary TB management despite the advent of modern antitubercular therapy. A partial nephrectomy is recommended for localised polar lesions containing calcification which fail to respond to six weeks of intensive chemotherapy or for areas of calcification which slowly increase in size and threaten to gradually destroy the entire kidney.6 Complete nephrectomies are indicated only for non-functioning tubercular kidneys with calcification or for cases of extensive disease involving the whole kidney occurring with other complications (e.g. hypertension or a coexistent renal cell carcinoma).20 A minimum of four weeks of antitubercular therapy is recommended before any major surgical intervention as it stabilises the lesion and allows greater accuracy during recon- structive surgery.6,21 Conclusion Renal TB should be considered in the differential diagnosis of a paediatric renal mass. A high degree of suspicion is warranted, especially for patients from countries with a high prevalence of TB. 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