Osteomas are benign osteogenic lesionspredominantly found in the craniomaxillo- facial bones which can be central, peripheral or extraskeletal, arising either from the endosteum, periosteum or soft tissues, respectively.1,2 Peripheral osteomas of the jaw bones are quite rare and usually remain asymptomatic until they cause asymmetry or compression of the adjacent structures due to their progressive growth.1–3 Although developmental, infect- ious, traumatic and neoplastic theories have been proposed, the exact aetiology of these lesions is still unknown.4,5 Osteomas have been reported to arise from bone graft sites.6 Multiple maxillofacial osteomas can also occur among patients with Gardner’s syndrome.5,7,8 This report presents a rare case of solitary peripheral osteoma of the hard palate, followed by a comprehensive literature review. Case Report A 72-year-old female patient presented to the Depart- ment of Oral & Maxillofacial Surgery, Dental School of Athens, Athens, Greece, in 2015 with complaints of swelling of the palate following extraction of her upper right second molar. Eight months earlier, she had noticed a slowly growing asymptomatic mass in the palate at the site of the extraction. She had a medical history of hypothyroidism, diabetes mellitus, arterial hypertension, hypercholesterolaemia, osteo- paenia and phlebitis. A clinical examination revealed a well-defined firm bony painless mass of approxi- mately 2 cm in diameter located in the posterior right part of the hard palate. The overlying mucosa was intact with no ulcerations, associated pain or changes in colour [Figure 1A]. Cone-beam computed tomography (CBCT) revealed a well-defined ‘mushroom’-like exophytic pedunculated radiopaque lesion originating from the palatine bone [Figure 2]. A comprehensive examination for Gardner’s syndrome was negative. Based on the clinical and radiographical findings, a diagnosis of a peripheral osteoma was made and an excisional biopsy was performed. Under local anaesthesia, a mucosal incision was made and a full- thickness flap was elevated. The lesion was well- circumscribed and attached by a pedicle to the adja- cent alveolar bone of the palate. Using a chisel and mallet, the lesion was removed and the surgical site debrided. The flap was closed with non-absorbable Department of Oral & Maxillofacial Surgery, Dental School of Athens, Athens, Greece *Corresponding Author e-mail: fboudaniotis@yahoo.gr األورام العظمية الطرفية اإلنفرادية للحنك الصلب تقرير حالة ومراجعة األدبيات فوتيو�س بونتانيوتي�س، اإيوني�س ميالكوبولو�س، فوتيو�س تزيربو�س abstract: Osteomas are benign slow-growing osteogenic lesions of unknown aetiology which can be central, peripheral or extraskeletal. Peripheral osteomas of the maxilla are very uncommon. We report a 72-year-old female patient who presented to the Department of Oral & Maxillofacial Surgery, Dental School of Athens, Athens, Greece, in 2015 with swelling of the palate following a tooth extraction. Clinical and radiographical features were indicative of a solitary peripheral osteoma of the hard palate. An excisional biopsy and histological examination of the lesion confirmed the diagnosis. No complications occurred during the postoperative period and there was no evidence of recurrence at a one-year follow-up. Keywords: Bone Tissue Neoplasms; Osteomas; Maxilla; Hard Palate; Case Report; Greece. امللخ�ص: االأورام العظمية من االآفات احلميدة بطيئة النمو الغري معروفة ال�سبب و ميكن اأن تكون مركزية، طرفية اأو خارج اجلهازالعظمي. االأورام العظمية الطرفية بالفك العلوي غري �سائعة. ن�سجل هنا حالة مري�سة تبلغ من العمر 72 عاما قدمت اإىل ق�سم جراحة الفم والوجه والفكني، كلية طب االأ�سنان، اأثينا، اليونان، عام 2015، مع تورم يف احلنك بعد خلع اأحد االأ�سنان. كانت اخل�سائ�س ال�رشيرية وال�سعاعية تدل على وجود ورم عظمي طريف انفرادي يف احلنك ال�سلب. واأكدت اخلزعة اال�ستئ�سالية وفح�س اله�ستولوجي هذا الت�سخي�س. مل حتدث اأي م�ساعفات خالل فرتة ما بعد اجلراحة ومل يكن هناك تكرار للحاله خالل �سنة من املتابعه. الكلمات املفتاحية: اأورام االأن�سجة العظمية؛ االأورام العظمية؛ الفك العلوي؛ احلنك ال�سلب؛ تقرير حالة؛ اليونان. Solitary Peripheral Osteoma of the Hard Palate Case report and literature review *Fotios Bountaniotis, Ioannis Melakopoulos, Fotios Tzerbos Sultan Qaboos University Med J, May 2017, Vol. 17, Iss. 2, pp. e234–237, Epub. 20 Jun 17 Submitted 25 Sep 16 Revision Req. 31 Oct 16; Revision Recd. 15 Nov 16 Accepted 15 Dec 16 case report doi: 10.18295/squmj.2016.17.02.018 Fotios Bountaniotis, Ioannis Melakopoulos and Fotios Tzerbos Case Report | e235 3-0 silk sutures. There were no postoperative compli- cations. A histopathological examination revealed mature compact and cancellous bone with marrow spaces and osteocytes, confirming the diagnosis of a peripheral osteoma [Figure 3]. At a one-year follow-up, the patient had healed completely and there was no evidence of recurrence [Figure 1B]. Discussion According to Boffano et al., patients with osteomas have a mean age of 48 years and the male-to-female ratio is 0.4:1.9 In the jaws, osteomas appear either on the surface of the bones, as pedunculated and sessile masses arising from the periosteum, or in the medullary space arising from the endosteum.2,4,10 Peripheral osteomas of the maxillofacial area are rare, appearing mainly in the paranasal sinuses; the most common site is the frontal sinus, followed by the ethmoidal and maxillary sinuses.8,11 Solitary peripheral osteomas of the jaw bones are very uncommon and generally involve the mandible more often than the maxilla.1–3,12 Clinical symptoms of an osteoma depend on the location, size and direction of tumour growth; generally, osteomas of the maxillofacial bones remain asymptomatic until they grow large enough to cause disfigurement or compression of the adjacent structures.1–3 Neurological symptoms caused by nerve compression may also occur.3,13 On histology, osteomas may be either compact or cancellous masses. Compact osteomas usually have a sessile base with normal-appearing dense bone, while cancellous osteomas are generally pedunculated and resemble the bone of origin.14,15 Radiographically, peripheral osteomas appear as well- circumscribed pedunculated or sessile radiopaque masses which seem to have normal bone density.16 In cases of superimposition of the lesion on imaging, CBCT can be useful.17 However, it may be difficult to differentiate peripheral osteomas from other lesions using imaging techniques; the differential diagnosis includes peripheral ossifying fibromas, exostoses, sessile osteochondromas, osteoid osteomas, periosteal osteoblastomas and parosteal osteosarcomas.4,5,15 The patient’s medical history and clinical characteristics of the lesion can be helpful in distinguishing a peripheral osteoma from an exostosis, even though there are no histological differences between the two entities; an osteoma will continue to grow during adulthood, unlike exostoses, which usually stop growing after puberty.5,14,18 In addition, the osteoid subtype of Figure 1: Intraoral photographs of the oral cavity of a 72-year-old female patient (A) at presentation showing a well- defined firm bony painless mass (arrow) in the posterior right part of the hard palate covered by intact mucosa and (B) one year after the successful excisional biopsy of a solitary peripheral osteoma of the hard palate. Figure 3: Haematoxylin and eosin stain at x200 magnification showing a osteoma consisting of lamellar bone (black arrow), osteocytes (white arrow) and marrow spaces (arrowhead). Figure 2: Cone-beam computed tomography of a 72-year-old female patient with swelling of the palate showing a ‘mushroom’-like exophytic radiopaque mass originating from the palatine bones (arrows). Solitary Peripheral Osteoma of the Hard Palate Case report and literature review e236 | SQU Medical Journal, May 2017, Volume 17, Issue 2 osteomas usually grows rapidly and is painful.14,19 A periosteal osteoblastoma has similar characteristics in terms of growth rate and symptoms.14,19 Similar to an osteoma, a peripheral ossifying fibroma appears as a radiopaque mass; however, it does not intrude into the cortical bone.15,19 In the current case, the clinical and radiographical features were indicative of a peripheral osteoma. It is difficult to clinically and histologically differentiate an osteoma from torus palatinus; however, the latter is usually located in the midline of the hard palate.19,20 It is worth mentioning that the patient in the present case had undergone a tooth extraction in the area of the osteoma a few months previously; however, it is not clear if this trauma was related to the aetiology of the lesion. Although asymptomatic osteomas are treated conservatively with regular follow-up, surgical excision is necessary if the lesion becomes symptomatic, grows too large or is indicated for cosmetic reasons.3 The surgical removal of osteomas is usually performed with a chisel and mallet, as in the present case, although rotary instruments can also be used. Following the surgery, recurrence of the lesion is extremely uncommon and malignant transformation has not been reported to date.3,11 The appearance of an osteoma in the maxillofacial region should raise suspicions of Gardner’s syndrome; this conditions consists of multiple peripheral and/or central osteomas in any bone—most frequently those in the craniomaxillofacial area—as well as cutaneous sebaceous cysts, desmoid tumours, multiple super- numerary teeth and colorectal polyposis.5,7,8 Symptoms may also include rectal bleeding, diarrhoea and abdominal pain. In patients with Gardner’s syndrome, the osteomas often develop before the colorectal polyposis; therefore, an early diagnosis is of paramount importance.2,3,7 The patient in the current case underwent a thorough examination for Gardner’s syndrome, which was eventually ruled out. 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