1Department of Nursing, Faculty of Nursing & Midwifery, Urmia University of Medical Sciences, Urmia, Iran; 2School of Health, Nursing & Midwifery, University of the West of Scotland, Paisley, UK *Corresponding Author’s e-mail: milan.z.nu93@gmail.com نتائج التعليم مبساعدة األقران والفيديو واجلمع بني التعليم باألقران والفيديو على القلق لدى املرضى اخلاضعني لتصوير األوعية التاجية دراسة سريرية منضبطة ح�سني حبيب زاده، زهرة داالي ميالن، موالود رادفر، ليلى عليلو، اأردري كوند abstract: Objectives: Coronary angiography can be stressful for patients and anxiety-caused physiological responses during the procedure increase the risk of dysrhythmia, coronary artery spasms and rupture. This study therefore aimed to investigate the effects of peer, video and combined peer-and-video training on anxiety among patients undergoing coronary angiography. Methods: This single-blinded randomised controlled clinical trial was conducted at two large educational hospitals in Iran between April and July 2016. A total of 120 adult patients undergoing coronary angiography were recruited. Using a block randomisation method, participants were assigned to one of four groups, with those in the control group receiving no training and those in the three intervention groups receiving either peer-facilitated training, video-based training or a combination of both. A Persian-language validated version of the State-Trait Anxiety Inventory was used to measure pre- and post-intervention anxiety. Results: There were no statistically significant differences in mean pre-intervention anxiety scores between the four groups (F = 0.31; P = 0.81). In contrast, there was a significant reduction in post-intervention anxiety among all three intervention groups compared to the control group (F = 27.71; P <0.01); however, there was no significant difference in anxiety level in terms of the type of intervention used. Conclusion: Peer, video and combined peer-and-video education were equally effective in reducing angiography-related patient anxiety. Such techniques are recommended to reduce anxiety amongst patients undergoing coronary angiography in hospitals in Iran. Keywords: Cardiac Imaging Techniques; Coronary Angiography; Anxiety; Patient Education; Iran. امللخ�ص: الهدف: ت�سوير االأوعية التاجية ميكن اأن يكون مقلقا للمر�سى وردود القلق الف�سيولوجية اأثناء التدخل قد يزيد من خطورة عدم واجلمع والفيديو االأقران تثقيف نتائج من التحقق اإىل الدرا�سة هذة تهدف والتمزق. التاجي ال�رصيان وت�سنجات القلب �رصبات انتظام بينهما على القلق عند املر�سى الذين �سيخ�سعون لت�سوير االأوعية التاجية. الطريقة: مت اإجراء هذة الدرا�سة الطبية املن�سبطة يف م�ست�سفيني تعلمني كبريين يف اإيران من اأبريل اإىل اأغ�سط�ض 2016. مت جتنيد جمموع 120 مري�سا �سيخ�سعون لعملية ت�سوير االأوعية التاجية. باأ�ستخدام طريقة الكتلة الع�سوائية، مت تعيني امل�ساركني اإىل اأحد االأربع جمموعات، بحيث اأن امل�ساركني يف جمموعة التحكم مل يتلقوا اأي تدريب و من الفار�سية باللغة حمققة ن�سخة اأ�ستخدام الحقا مت كليهما. اأو الفيديو اأو االأقران م�ساعدة اإما تلقت التداخلية جمموعات الثالثة بقية القلق نتائج متو�سط يف معتد اإح�سائي فارق اأي هناك يكن مل التدخل. النتائج: وبعد قبل القلق م�ستوى لقيا�ض القلق �سمة قائمة حالة جميع بني التدخل بعد القلق يف كبري انخفا�ض هناك كان املقابل، يف .)F = 0.31; P = 0.81( جمموعات االأربع بني التدخل قبل ما جمموعات التدخل الثالثة مقارنة مع جمموعة التحكم )F = 27.71; P >0.01(؛ اإال اأنه مل يوجد فارق معتد مل�ستوى القلق من حيث نوعية التدخل امل�ستخدم. اخلال�صة: اأ�ستخدام و�سائل التدري�ض باالأقران والفيديو واجلمع بينهما تعترب و�سائل فعالة يف خف�ض م�ستوىات القلق املرتبطة بت�سوير االأوعية التاجية. هذة الو�سائل يو�سى بها لتخفي�ض م�ستوى القلق للمر�سى الذين يخ�سعون لت�سوير االأوعية التاجية يف امل�ست�سفيات االإيرانية. الكلمات املفتاحية: طرق الت�سوير القلبي؛ ت�سوير االأوعية التاجية؛ القلق؛ تثقيف املري�ض؛ اإيران. Effects of Peer-Facilitated, Video-Based and Combined Peer-and-Video Education on Anxiety Among Patients Undergoing Coronary Angiography Randomised controlled trial Hosein Habibzadeh,1 *Zahra D. Milan,1 Moloud Radfar,1 Leyla Alilu,1 Audrey Cund2 clinical & basic research Sultan Qaboos University Med J, February 2018, Vol. 18, Iss. 1, pp. e61–67, Epub. 4 Apr 18 Submitted 11 Jul 17 Revisions Req. 14 Sep & 6 Nov 17; Revisions Recd. 19 Oct & 20 Nov 17 Accepted 23 Nov 17 doi: 10.18295/squmj.2018.18.01.010 Advances in Knowledge - The findings of this study indicate that either peer-facilitated training, video-based training or a combination of both may reduce the anxiety levels of patients undergoing coronary angiography. Application to Patient Care - Peer-facilitated, video-based or peer-and-video training is recommended to reduce anxiety among patients undergoing coronary angiography in Iranian hospitals. Effects of Peer-Facilitated, Video-Based and Combined Peer-and-Video Education on Anxiety Among Patients Undergoing Coronary Angiography Randomised controlled trial e62 | SQU Medical Journal, February 2018, Volume 18, Issue 1 Anxiety is an emotional state whereby an individual experiences feelings of uneasi-ness or apprehension in response to a per- ceived or actual threat. The subsequent activation of the autonomic nervous system can trigger various physical symptoms, including palpitations, tachycardia and chest pain.1 Moreover, intense anxiety is assoc- iated with decreased immune response and changes in cardiovascular function, such as impaired heart rate, endothelial dysfunction and vascular inflammation, which may lead to a deterioration in a patient’s coronary condition.2 Previous research has shown that patients undergoing clinical or surgical procedures such as coronary angiography often experience high levels of anxiety.3,4 As such, methods to improve clinical out- comes and identify appropriate interventions to reduce patient anxiety are necessary. For patients undergoing coronary angiography or similar procedures, a lack of knowledge regarding the procedure may be directly related to their anxiety levels; accordingly, the provision of necessary, detailed and accurate procedure-related information as well as a breakdown of the actions that must be taken before, during and after the procedure can help reduce stress and anxiety.4–7 Several studies have confirmed the effect- iveness of providing information about the angiography process in reducing patient anxiety.8,9 However, further research is required to identify the most effective approach and time to prepare a patient and their family for the procedure.10 The use of an appropriate educational technique—such as educational leaflets or peer-facilitated or video-based training—may be effect- ive in reducing patient anxiety.11 Peer-facilitated train- ing is based on the social learning theory that people learn from each other via observation, imitation and modelling; patients can therefore benefit from their peers’ experiences in terms of learning to cope with their illness or the planned investigation.12 Video-based train- ing may also reduce anxiety, stress and depression while a combination of both visual and auditory inform- ation is an effective tool to facilitate knowledge acqui- sition and retention, reduce anxiety, improve coping skills and increase self-care behaviours.13,14 However, while the use of peer-facilitated and video-based patient education is well established world- wide, there is a lack of research on this topic in Iran. Moreover, although medical technologies have prog- ressed rapidly, strategies focusing on health education, promotion and self-management are not yet widely implemented in Iranian hospitals. This study therefore sought to investigate the effects of peer-facilitated, video-based and combined peer-and-video training on anxiety among patients undergoing coronary angio- graphy at two hospitals in Iran. Methods This randomised controlled trial was conducted among 120 patients undergoing coronary angiography at two large educational hospitals in Iran between April and July 2016. Patients were recruited from the Ayatollah Taleghani Hospital and Seyed-al-Shohada Hospital in Urmia. Only patients aged 18–80 years old with no prior history of angiography and no cognitive disorders or physical disabilities were included in the study. Patients were excluded if they underwent emergency angiography, were employed as a staff member at the hospital, were receiving intensive care or had been admitted to the cardiac care unit. The necessary sample size was calculated as a minimum of 23 participants per group at a confidence level and test power of 95%.15 Accounting for potential participant loss, 30 patients per group were subsequently recruited for a total of 120 patients [Figure 1]. Figure 1: Diagram showing the clinical trial design used in the current study. Once randomly assigned to each group, none of the patients were lost to follow-up or excluded from the final analysis. Hosein Habibzadeh, Zahra D. Milan, Moloud Radfar, Leyla Alilu and Audrey Cund Clinical and Basic Research | e63 A single-blind clinical trial design was adopted with four parallel arms to examine the effects of peer- facilitated, video-based and combined peer-and-video training as an intervention to reduce anxiety levels in patients undergoing coronary angiography. Partic- ipants were randomly assigned to each group on a weekly basis to avoid interference between the groups. In the first week, the first group received peer-facil- itated training, while the second group received video- based training the following week and the third group received combined peer-and-video training the week after that. In the fourth week, the control group received routine care. Recruitment continued until the required sample size was achieved. To avoid data contamination arising from patients discussing their experiences with each other and to minimise researcher bias, the recruitment and sampling process for each subsequent group occurred once all previous patients from the previous week had been discharged. Patients were randomly allocated to a group by a person uninvolved in the sampling and data collection process. Each intervention took place in a quiet room with sufficient lighting and suitable seating on the evening before the angiography procedure. The first inter- vention group took part in a 30-minute peer-facilitated training session. Under the supervision of the researcher, two patients who had recently undergone angiography were asked to talk to between four and six of the parti- cipants about their feelings and experiences before, during and after the procedure. In the video-based intervention group, the participants watched a five- minute movie about what they should expect before, during, and after angiography and another 15-minute movie filmed within the actual operating room where the procedure would take place. Both movies were broadcast under the researcher’s supervision during a 20-minute period. At the end of the intervention, the effectiveness of the film was evaluated during a brief question-answer session. In the combined peer-and-video intervention group, all of the training steps described for the afore- mentioned groups were performed. As before, a 20- minute video-based training session took place; then, after a 15-minute break, a 30-minute peer-facilitated group session was carried out under the supervision of the researcher. Verbal feedback was again used to evaluate effectiveness of the training. For those in the control group, each participant received routine care which involved no education or preparation for the procedure from a health professional. Regardless of group, each patient was admitted to the hospital in advance of the procedure for surveillance purposes, including the monitoring of their vital signs, labor- atory tests and an electrocardiogram. All participants remained under the supervision of the researcher between the end of the intervention and the beginning of the procedure. The State-Trait Anxiety Inventory (STAI) is a 20-item questionnaire tool designed to assess an individual’s feelings at the time of assessment.16 A Persian-language version of the STAI questionnaire was used to measure patient anxiety both the day before the coronary angiography prior to the delivery of any training as well as 30 minutes before the patient was transferred to the operating room. Responses to the STAI questionnaire were self-assessed by partic- ipants and scored on a four-point Likert scale, with one indicating “not at all anxious”, two indicating “sometimes anxious”, three indicating “often anxious” and four indicating “frequently anxious.” Total anxiety scores from 20–80 were calculated for each patient, with scores of 20–29, 30–49, 50–69 and 70–80 indic- ating mild, relatively mild, relatively severe and severe anxiety, respectively. The questionnaire had been previously validated in Iran with a Cronbach’s alpha of 0.91.17 Demographic and clinical characteristics of the participants were also recorded, including age, gender, duration of disease, marital status, history of hospitalisation, education level and economic status. Economic status was classified as unfavourable (monthly income of <$250 USD), partly favourable (monthly income of $250–500 USD) or favourable (monthly income of >$500 USD). Data were analysed using the Statistical Package for the Social Sciences (SPSS), Version 19.0 (IBM Corp., Armonk, New York, USA). The normality of the quan- titative data was confirmed using a Kolmogorov- Smirnov test. A Chi-squared test and one-way analysis of variance was used to compare the sociodemo- graphic and clinical characteristics of the groups, as appropriate. A Tukey’s post-hoc test was employed for the pairwise comparison of post-intervention differences in anxiety scores between the groups. A P value of ≤0.05 was considered statistically significant. Ethical approval for this study was obtained from the Committee of Ethics of the Urmia University of Medical Sciences, Urmia, Iran (#IR.umsu.rec.1395,21). This study was registered under the Iranian Registry of Clinical Trials (#2016072429052N1). Written informed consent was obtained from all participants prior to their inclusion in the study. Results Table 1 shows the sociodemographic characteristics of the participants according to group. There were no significant differences between the groups in terms of age, gender, marital status, duration of disease, history of Effects of Peer-Facilitated, Video-Based and Combined Peer-and-Video Education on Anxiety Among Patients Undergoing Coronary Angiography Randomised controlled trial e64 | SQU Medical Journal, February 2018, Volume 18, Issue 1 hospitalisation, presence of chronic disease and income or education levels; accordingly, all four groups were considered homogenous. Mean pre-intervention anxiety scores were 41.40 ± 9.90, 41.80 ± 8.76, 39.96 ± 8.28 and 40.00 ± 9.98 for the peer education, video education, combined peer-and-video education and control groups, respect- ively, with no statistically significant difference between the groups (P = 0.81). However, mean post-intervention anxiety scores were 34.30 ± 7.21, 36.23 ± 7.29, 30.73 ± 5.56 and 42.86 ± 11.64, respectively, with a statistically signif- icant difference between the intervention groups and the control group (P <0.01). The mean difference between pre- and post-intervention anxiety scores was -6.70 ± 4.39, -5.53 ± 2.19 and -7.56 ± 6.45 for the peer education, video education and combined peer-and- video education groups, respectively, in contrast to the control group (5.85 ± 2.86; P <0.01) [Table 2]. A pairwise comparison showed a statistically signi- ficant mean difference between pre- and post-interven- tion anxiety scores of participants undergoing peer- facilitated training group, video-based training or com- bined peer-and-video training in comparison to the control group; however, there was no significant differ- ence in terms of the type of intervention used [Table 3]. Table 1: Sociodemographic and clinical characteristics of adult patients undergoing coronary angiography at two large hospitals in Iran (N = 120) Characteristic n (%) P value Peer intervention group Video intervention group Combined intervention group Control group Age in years 35–50 5 (17) 9 (30) 8 (27) 12 (40) 0.51†51–65 18 (60) 17 (57) 15 (50) 14 (47) 66–80 7 (23) 4 (13) 7 (23) 4 (13) Mean ± SD 58.80 ± 8.57 56.07 ± 8.89 57.27 ± 9.32 54.30 ± 9.79 0.28* Gender Male 16 (53) 16 (53) 15 (50) 17 (57) 0.96† Female 14 (47) 14 (47) 15 (50) 13 (43) Marital status Married 26 (87) 23 (77) 29 (97) 28 (93) 0.11† Unmarried 4 (13) 7 (23) 1 (3) 2 (7) Medical history Presence of chronic disease 17 (57) 17 (57) 13 (43) 13 (43) 0.77† Mean duration of disease in years ± SD 3.12 ± 2.47 3.21 ± 2.60 1.70 ± 1.67 2.60 ± 1.97 0.51* History of hospitalisation 19 (63) 0 (0) 15 (50) 15 (50) 0.65† Mean number of hospital admissions ± SD 1.46 ± 1.17 2.45 ± 1.60 1.06 ± 0.90 0.99 ± 0.80 0.22* Years of education 9–11 24 (80) 24 (80) 20 (67) 22 (74) 0.39†12 6 (20) 6 (20) 10 (33) 7 (23) >13 0 (0) 0 (0) 0 (0) 1 (3) Economic status Unfavourable 17 (57) 20 (67) 17 (57) 18 (60) 0.98†Partly favourable 9 (30) 7 (23) 10 (33) 9 (30) Favourable 4 (13) 3 (10) 3 (10) 3 (10) SD = standard deviation. *Calculated using a one-way analysis of variance. †Calculated using a Chi-squared test. Hosein Habibzadeh, Zahra D. Milan, Moloud Radfar, Leyla Alilu and Audrey Cund Clinical and Basic Research | e65 Discussion In the current study, peer-facilitated training, video- based training and combined peer-and-video training were all found to significantly reduce anxiety levels among patients undergoing coronary angiography in comparison to a control group. Lundén et al. similarly found that it was necessary to provide patients with comprehensive and accurate information reflecting the actual conditions of the angioplasty unit in order for patients to remain calm during and after an angioplasty procedure.18 Tame et al. also confirmed that written and verbal education was an effective approach to reduc- ing preoperative anxiety.19 However, in another rando- mised controlled trial, Goodman et al. found that prov- iding information alone had no significant effect on levels of anxiety among patients scheduled for a coro- nary artery bypass surgery.20 In the present study, one of the interventions involved patients watching video footage taken in the surgical environment and an explanation of the actions taken before, during and after the procedure. Tou et al. also found a reduction in patients’ anxiety levels follow- ing a video-based intervention.21 Previous studies have concluded that peer-facilitated training is similarly effective in reducing anxiety among patients who are candidates for coronary surgery or who have multiple sclerosis.9,22 Eslami et al. noted reduced mean stress scores among patients undergoing coronary angio- graphy who participated in peer-facilitated education in comparison to a control group.23 One explanation for the efficacy of this educational technique may be that patients trust and respect the views and experiences of individuals with similar conditions or undergoing similar medical procedures. The use of a combined peer-and-video training has also been previously found to be effective in reducing patient anxiety; Moumeni et al. observed that supple- menting video training sessions with an educational booklet led to reduced preoperative as well as post- intervention anxiety among patients undergoing coro- nary artery bypass grafting.24 A similar study found that a combined education programme reduced anxiety among orthopaedic surgery candidates.25 In addition, Mosavi et al. showed that anxiety and depression among open heart surgery patients were significantly reduced using face-to-face training combined with an educational booklet.26 Overall, the results of the current study found no significant difference in post-intervention anxiety reduction between the three different interventions; in other words, peer-facilitated, video-based and com- bined peer-and-video training were all equally effective in reducing anxiety among patients undergoing angio- graphy. This finding is consistent with the results of previous research.27–29 Najafi et al. reported no signif- icant difference in terms of state and trait anxiety levels among echocardiography patients undergoing various Table 3: Comparison of anxiety scores* between intervention groups among adult patients undergoing coronary angiography at two large hospitals in Iran (N = 120) Group B Group A Peer intervention group Video intervention group Combined intervention group Difference† P value‡ Difference† P value‡ Difference† P value‡ Video intervention group -1.93 0.80 - - - - Combined intervention group 3.56 0.35 5.50 0.05 - - Control group -8.56 <0.01 -6.63 0.01 -12.13 <0.01 *Anxiety levels were assessed using a validated version of the 20-item State-Trait Anxiety Inventory.16,17 †Mean difference in anxiety score in group A versus B for post-intervention comparisons. ‡Calculated using Tukey’s post hoc test. Table 2: Anxiety scores* according to intervention group among adult patients undergoing coronary angiography at two large hospitals in Iran (N = 120) Mean anxiety score ± SD P value† Peer intervention group Video intervention group Combined intervention group Control group Pre-intervention 41.40 ± 9.90 41.80 ± 8.76 39.96 ± 8.28 40.00 ± 9.98 0.81 Post-intervention 34.30 ± 7.21 36.23 ± 7.29 30.73 ± 5.56 42.86 ± 11.64 <0.01 Mean difference -6.70 ± 4.39 -5.53 ± 2.19 -7.56 ± 6.45 5.85 ± 2.86 <0.01 SD = standard deviation. *Anxiety levels were assessed using a validated version of the 20-item State-Trait Anxiety Inventory.16,17 †Calculated using a one-way analysis of variance. Effects of Peer-Facilitated, Video-Based and Combined Peer-and-Video Education on Anxiety Among Patients Undergoing Coronary Angiography Randomised controlled trial e66 | SQU Medical Journal, February 2018, Volume 18, Issue 1 forms of training (booklets and face-to-face training).27 Face-to-face, pamphlet and electronic training among patients with acute myocardial infarctions have similarly resulted in no statistically significant differences in anxiety levels according to the type of training received.28,29 The current study is subject to certain limit- ations. As patients were hospitalised one day before the angiography procedure, the amount of time available for patients to take part in training or review informa- tion about the procedure was minimal. Hence, patients undergoing emergency angiography and those hospital- ised on the day of the procedure were excluded as there was insufficient time to perform the pre-procedure training; furthermore, inconsistencies in the length of time between the training and the procedure might affect the generalisability of the findings. However, the anxiety levels of such patients should be determined and further studies should include these patients in the analysis. Furthermore, in order to avoid data contamin- ation and researcher bias, patients in the current study were recruited in staggered phases, with new participants recruited only after all those involved in the previous intervention had been discharged. However, physiological variations among patients were not investigated; thus, it is recommended that future studies include appropriate measurements to rule out the impact of clinical and haemodynamic parameters on anxiety. Moreover, prior knowledge of a coronary angiography procedure—for example, gleaned from the Internet or based on the experiences of friends or family members—may have influenced feelings of anxiety among the partic- ipants, regardless of intervention type. Future research should seek to determine baseline levels of knowledge of the procedure prior to ascertaining anxiety levels. Conclusion This study found that peer-facilitated, video-based and combined peer-and-video training were equally effective in reducing anxiety among patients under- going coronary angiography in comparison to a control group. Such methods are therefore recommended and may be incorporated as part of routine pre-angiography clinical care in Iranian hospitals in order to reduce patient anxiety. c o n f l i c t o f i n t e r e s t The authors declare no conflict of interest. f u n d i n g This study was funded with the aid of a grant from the Urmia University of Medical Sciences (grant #IR. umsu.rec.1395.21). 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