Departments of 1Neurology and 2Medical Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran; 3Rocky Mountain Poison and Drug Center, Denver Health Medical Center, Denver, Colorado, USA; 4Department of Clinical Toxicology, Loghman Hakim Hospital, Tehran, Iran *Corresponding Author’s e-mail: omid.mehrpour@yahoo.com.au التسمم بالرصاص نتيجة البتالع أفيون ملوث بالرصاص عند مريض أظهر اعتالال عصبيا حركيا وخزل بالطرف العلوي تقرير حالة مو�شوي حممد �شيد، اأكربي اأيوب، ماهبور اأومد، زمانين�شيم abstract: Opium users may present with central or peripheral nervous system-related symptoms, gastrointestinal complications and anaemia; in such cases, lead poisoning should be suspected and chelation therapy initiated as soon as possible. We report a 64-year-old male patient with a 20-year history of opium addiction who was referred to the Imam Reza Hospital, Birjand, Iran, in 2017 with severe motor neuropathy and paresis in both upper limbs. His primary symptoms were generalised weakness, abdominal and bone pain, constipation and lower limb paraesthesia that had started several months prior. In addition, he reported severe progressive bilateral paresis of the upper limbs of one month’s duration. A diagnosis of lead poisoning was confirmed by a blood lead level of 140 µg/dL. The patient underwent chelation therapy after which he improved significantly. At a one-year follow-up visit, he was neurologically intact and symptom-free. Keywords: Opium Dependence; Lead Poisoning; Lead-Induced Nervous System Diseases; Paresthesia; Case Report; Iran. امللخ�ص: يظهر م�شتخدمو الأفيون اأعرا�شا مرتبطة باجلهازين الع�شبي املركزي والطريف وم�شاعفات معدية معوية وفقر دم؛ ويف هذه احلالت ينبغي ال�شتباه يف الت�شمم بالر�شا�س، والبدء يف العالج بالحتاد املخلبي باأ�رصع ما ميكن. ون�شجل هنا حالة رجل عمره 64 عاما ظل ي�شتخدم الأفيون ملدة 20 �شنة و�شار مدمنا له ومت حتويله عام 2017م اإىل م�شت�شفى الإمام ر�شا ببريجند يف اإيران، وهو م�شاب باعتالل ع�شبي مفرط وَخَزل بالطرفني العلويني. وكانت الأعر�س الرئي�شة عنده هي وهن عام، واآلم يف البطن والعظام، واإم�شاك، وَمَذل يف الطرفني ال�شفليني، وهي اأعرا�س بداأت عند هذا املري�س قبل عدة �شهور قبل حتويله للم�شت�شفى. كذلك حدث للمري�س َخَزل بالطرفني العلويني قبل نحو �شهر. واأثبت فح�س للدم وجود ت�شمم بالر�شا�س، اإذ اأن تركيزه بلغ 140 ميكروجرام/100 مل من الدم. ومت اإجراء عالج خملبي للمري�س اأدي لتح�شن حالة املري�س ب�شورة ملحوظة. وعند مراجعة املري�س للم�شت�شفى بعد عام على ذلك العالج وجد اأنه �شليم ع�شبيا ولي�شت لديه اأي اأعرا�س. الكلمات املفتاحية: اإدمان الأفيون؛ الت�شمم بالر�شا�س؛ اأمرا�س اجلهاز الع�شبي التي ي�شببها الر�شا�س؛ َمَذل؛ تقرير حالة؛ اإيران. Lead Toxicity due to Ingestion of Lead-Contaminated Opium in a Patient Presenting with Motor Neuropathy and Upper Limb Paresis A case report Seyed M. M. Mirzaei,1 Ayob Akbari,2 *Omid Mehrpour,3 Nasim Zamani4 case report Sultan Qaboos University Med J, November 2018, Vol. 18, Iss. 4, pp. e529–532, Epub. 28 Mar 19 Submitted 2 May 18 Revision Req. 27 May 18; Revision Recd. 22 Jun 18 Accepted 19 Jul 18 doi: 10.18295/squmj.2018.18.04.017 In recent years, lead poisoning due to the ingestion of lead-contaminated opium has become a major health concern in Iran.4–9 According to Ghane et al., more than 4,000 patients with lead poisoning due to opium ingestion were referred in under one year to clinical centres in Iran with abdominal pain and constipation.10 Moreover, the researchers estimated that over 260,000 out of >700,000 opium users remained untreated and at risk of lead poisoning.10 This case report describes a patient who presented to Imam Reza Hospital, the main referral centre for poisoning cases in the South Khorasan province of Iran, with severe lead-induced motor neuropathy due to the ingestion of lead-contam- inated opium. Exposure to certain toxic agents results in neurotoxicity which may lead to cognitive and memory disabilities, mood changes and even predispose the affected patient to psychiatric problems such as depression, anxiety and irritability.1 In factories producing glazed tiles, canned food, paint and cosmetics, workers may be affected by the presence of inorganic lead; in addition, drinking water and dust may be contaminated from industrial sources and motor vehicles.2,3 Another source of potential exposure is the presence of organic lead in opium.4,5 Lead may be intent- ionally added to the drug to increase its weight for profit- related reasons or it may be introduced accidentally during the production process.4–7 Subsequently, the lead is ingested by opium users either orally or via inhalation.6,8 Lead Toxicity due to Ingestion of Lead-Contaminated Opium in a Patient Presenting with Motor Neuropathy and Upper Limb Paresis A case report e530 | SQU Medical Journal, November 2018, Volume 18, Issue 4 Case Report A 64-year-old male patient was referred to the Imam Reza Hospital, Birjand, in 2017 with generalised weak- ness, abdominal and bone pain, constipation and lower limb paraesthesia that had first started several months prior. The patient had then developed severe paresis in both upper limbs 30 days previously. He reported a 20-year history of oral opium use consisting of approximately 5 g daily. A urine drug analysis was positive for opium. Upon examination, the cranial nerves were normal, as were lower limb deep tendon reflexes; however, deep tendon reflexes in the upper limbs, biceps and triceps were absent. No sensory impairment was detected. The muscular power in the upper limbs was 2/5 and 1/5 in the proximal and distal areas, respectively, while the lower limbs were normal. The median and ulnar nerves were moderately affected, while the radial nerve was severely affected; the patient also had bilateral wrist drop. Imaging studies yielded normal results, including brain and cervical magnetic resonance imaging (MRI), computed tomography (CT), a chest X-ray and abdominal ultrasonography. Brain CT and MRI scans revealed no evidence of a mass, haemorrhage, hydrocephalus or abnormalities in the basal ganglia and posterior fossa structures. No established infarct and intra- or extra-axial collections were detected in the major vessel vascular territory. The basal cisterns and foramen magnum were patent. The chest X-ray showed an increase in bilateral bronchovascular markings with no other abnormalities. Whole body bone scintigraphy was performed to rule out malignancy; this showed only minor tracer uptake throughout the skeleton. An endoscopy and colonoscopy revealed a 7-mm polypoid lesion in the D1-D2 junction of the duodenum and internal haemorrhoids in the anus. Electromyography confirmed chronic motor- sensory polyneuropathy with axonal features which were more severe in the upper limbs. Critically, the patient’s blood lead level was 140 µg/dL (normal range: <10 µg/dL). Table 1 shows the results of various other laboratory tests. Nerve conduction and F-wave parameters are shown in Tables 2–4. Based on his blood lead level, the patient was diagn- osed with lead poisoning and admitted to hospital. He was initially treated with 4 mg/kg of dimercaprol via deep intramuscular injection every four hours, followed by 1,300 mg/day of intravenous calcium disodium (CaNa 2) edetate four hours after the first dose of dimercaprol. After five days of parenteral treatment, his blood lead level was 60 µg/dL. He was discharged and prescribed 10 mg/kg of oral succimer, initially every eight hours for five days followed by every 12 hours for 14 days. After 21 days of treatment, his clinical symptoms began to improve, particularly the abdominal pain, generalised Table 1: Laboratory test results of a 64-year-old male opium addict with severe lead-induced motor neuropathy Variable Result Normal range White blood cell count in ×103/mm3 8.1 4–10 Haemoglobin in g/dL 9.6 14–18 Haematocrit in % 30.5 Males: 45–52 Females: 37–48 MCV in femtolitres 83.6 80–96 MCH count in pg 27.1 27–33 MCHC in % 32.5 32–36 Platelet count in ×103/mm3 206 150–450 Vitamin B12 in pg/mL 1,178 160–950 Folic acid in ng/mL 6 2–20 Serum iron in µg/dL 36.8 65–176 TIBC in µg/dL 176 240–450 Ferritin in ng/mL 338.9 12–300 Serum vitamin D in ng/mL 9.55 20–50 T3 in pg/mL 4 2.3–4.2 T4 in ng/dL 9.9 4.5–11.5 TSH in µIU/mL 0.5 0.5–4.7 T3RU in % 36.7 24–37 AST in U/L 50 <37 ALT in U/L 55 <41 Alkaline phosphatase in U/L 188 80–306 Total bilirubin in mg/dL 1.2 <1.1 Direct bilirubin in mg/dL 0.4 <0.6 Creatinine in mg/dL 1 0.5–1.4 Prothrombin time in seconds 13 10–13.5 Partial thromboplastin time in seconds 28 25–35 INR 1 <1.1 Wright agglutination test Negative Negative 2ME Negative Negative ANAs Negative Negative Rheumatoid factor Negative Negative Anti-ds-DNA in IU/mL 2.37 <10 Serum albumin in g/dL 3.6 3.5–5 α-globulin in g/dL 0.2 0.1–0.3 α-2-globulin in g/dL 0.8 0.6–1 β-globulin in g/dL 0.7 0.7–1.2 γ-globulin in g/dL 1.1 0.7–1.6 MCV = mean corpuscular volume; MCH = mean cell haemoglobin; MCHC = mean corpus- cular haemoglobin concentration; TIBC = total iron-binding capacity; T3 = triiodothyronine; T4 = thyroxine; TSH = thyroid-stimulating hormone; T3RU = T3 resin uptake; AST = aspar- tate aminotransferase; ALT = alanine aminotransferase; INR = international normalised ratio; 2ME = 2-mercaptoethanol; ANAs = antinuclear antibodies; ds = double-stranded. Seyed M. M. Mirzaei, Ayob Akbari, Omid Mehrpour and Nasim Zamani Case Report | e531 weakness and weakness in the upper limbs. However, at a three-month follow-up appointment, the patient reported that the upper limb weakness still persisted; moreover, his blood lead level was 44 µg/dL. Due to a shortage of succimer, D-penicillamine treatment was initiated at a dose of 250 mg every eight hours for 10 days. After this, a neurological examination was normal, including examination of the power in the upper limbs, although the patient still complained of some upper limb weakness. He was referred to a rehabilitation clinic to undergo methadone maintenance therapy. One year later, his blood lead level was 20 μg/dL and the upper limb weakness had completely resolved. Discussion Symptoms of acute lead poisoning include nausea, head- aches, cognitive problems and emotional impairment, while chronic lead exposure may cause fatigue, a decline in brain and cognitive function, motor impairment, psychiatric problems and, in some cases, a decline in nerve conduction velocity.11,12 Critically, initial symptoms of irritability, headache, fatigue, memory loss and tremors may progress to weakness, limb paralysis, seizures, deli- rium and hallucinations, coma and, eventually, death.13 As such, the early detection and immediate treatment of lead poisoning is imperative. Neuropathy due to the ingestion of lead-contam- inated opium is uncommon, with most patients presenting with anaemia and gastrointestinal symptoms.14,15 A comb- Table 2: Motor nerve conduction parameters of a 64-year- old male opium addict with severe lead-induced motor neuropathy Nerve and site/segment Latency in ms Amplitude in mV Distance in mm Velocity in m/s Right median APB Wrist 3.6 1.4 - - Wrist-elbow 8.9 1.3 240 44.5 Left median APB Wrist 3.3 1.0 - - Wrist-elbow 8.2 0.959 240 39.3 Right ulnar ADM Wrist 2.7 2.2 - - Wrist-below elbow 7.0 1.9 260 40.8 Left ulnar ADM Wrist 2.4 1.7 - - Wrist-below elbow 7.1 1.5 260 39.4 Right radial EIP Forearm Absent Absent - - Elbow Absent Absent - - Below spiral groove Absent Absent - - Left radial EIP Forearm Absent Absent - - Elbow Absent Absent - - Below spiral groove Absent Absent - - Right DPN EDB Ankle 3.5 1.8 - - Ankle below FH 9.1 1.7 - - Below FH-PF 9.8 1.8 350 41.3 Left DPN EDB Ankle 5.1 1.8 - - Ankle below FH 12.1 1.9 - - Below FH-PF 12.8 1.8 340 38.4 Right tibial AHB Medial ankle 6.3 3.1 - - Medial ankle- PF 14.3 2.9 380 37.7 Left tibial AHB Medial ankle 5.1 3.9 - - Medial ankle- PF 13.6 4.3 380 44.3 APB = abductor pollicis brevis; ADM = abductor digiti minimi; EIP = extensor indicis proprius; DPN = deep peroneal nerve; EDB = extensor digitorum brevis; FH = fibula head; PF = popliteal fossa; AHB = abductor hallucis brevis. Table 3: Sensory nerve conduction parameters of a 64-year-old male opium addict with severe lead-induced motor neuropathy Nerve Latency in ms Amplitude in uV Distance in mm Velocity in m/s Right median 4.0 14.6 130 43.1 Left median 3.6 9.64 130 47.2 Right ulnar 3.8 16.9 110 51.4 Left ulnar 3.5 14.3 110 50.4 Right radial 3.3 13.1 90 56.4 Left radial 3.1 15.3 90 60.5 Right sural 3.1 3.55 - - Left sural 2.7 3.0 - - Table 4: F-wave parameters of a 64-year-old male opium addict with severe lead-induced motor neuropathy Nerve Latency in ms F/M amplitude in uVms F % M F-M F min F max Right median APB 4.3 24.2 28.6 31.1 0.11 50 Left median APB 3.7 22.0 25.7 32.1 0.14 60 Right ulnar ADM 0.1 28.2 28.3 33.0 0.07 100 Right tibial AHB 6.4 48.3 54.7 62.3 0.05 75 Left tibial AHB 0.1 54.1 54.2 54.7 0.03 66 min = minimum; max = maximum; APB = abductor pollicis brevis; ADM = abductor digiti minimi; HB = abductor hallucis brevis. Lead Toxicity due to Ingestion of Lead-Contaminated Opium in a Patient Presenting with Motor Neuropathy and Upper Limb Paresis A case report e532 | SQU Medical Journal, November 2018, Volume 18, Issue 4 ination of motor and sensory nervous system impair- ment, as seen in the current case, is even less common. Lead-induced neuropathy commonly affects the radial and peroneal nerves and extensor muscles, resulting in wrist and foot drop, while sensory processing disorders are less frequent.2,16 Beigmohammadi et al. reported a 40-year-old male oral opium addict who presented with weakness of the limbs due to severe lead poisoning (blood lead level: 200 µg/dL).17 The patient had digestive symptoms (including stomach aches and constipation) and severe weakness of the upper and lower limbs, although sensation was normal. Despite treatment with CaNa2 edetate, dimercaprol and oral succimer, the patient remained quadriplegic, although both his blood lead levels and gastrointestinal symptoms improved.17 Toxic-metabolic polyneuropathy may be induced by extrinsic or intrinsic metabolites which are toxic to the peripheral nerves, resulting in damage to the axial cylinders of the axons. The severity of this damage is dependent on the level of toxicity, duration of exposure and genetic characteristics of nervous tissue metabolism.18 Clinically, the damage manifests as both sensory impair- ment and muscle weakness, although muscle wasting and severe trophic disorders may also occur. In these cases, electroneuromyography would show a decrease in the amplitude of peripheral nerve sensory potentials and muscle action potential.18 In patients with axonal-type polyneuropathy, there is often sufficient retention of motor function—in the absence of severe paresis—while sensory and trophic impairments are disabling. Axonal nerve damage develops slowly and gradually, although it is potentially reversible with appropriate treatment.18 In the current case, the patient developed both motor and sensory neuropathy due to long-term exposure to high levels of lead. However, all neurological symptoms completely resolved after treatment with chelating agents. Most patients with sensory complications are resistant to treatment and a full recovery is not expected, even after chelation therapy.16 This case emphasises the importance of the timely diagnosis and treatment of cases of lead toxicity in order to reverse central and peripheral nervous system-related symptoms. Conclusion Opium addicts are predisposed to developing lead toxicity resulting from the ingestion of lead-contaminated opium. This may result in the development of serious symptoms such as cognitive, sensory and motor impairment, with delays in diagnosis and treatment potentially resulting in irreversible neurological damage. 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