item: #1 of 204 id: translation-100 author: Gokula, Murthy; Gaspar, Phyllis M title: Implementation of the FIRM (Foley Insertion, Removal, and Maintenance) protocol in skilled nursing facilities date: 2014-08-21 words: 3964 flesch: 50 summary: Attaining almost 100% documentation of rationale for catheter use resulted from implemen- tation of the protocol and efforts of the inter-professional team. Von Preyss- Friedman (12) implemented a QI project in a SNF focused on IUC and included guidelines for IUC use, follow up audit process, and an in-service of nursing staff. keywords: care; catheter; implementation; iuc; maintenance; protocol; removal; residents; use cache: translation-100.pdf plain text: translation-100.txt item: #2 of 204 id: translation-101 author: Brickman, Kristopher A; Zaciewski, Tomas G; Bahl, Rajiv; Fink, Brian N; Gibbons, Maureen P; Sidani, Ramzi S; Audino, Anthony N; Ryno, Joseph J; Adams, Daniel Z; Wellock, Austin R title: Iontophoresis: as a new treatment modality in the management of acute soft tissue injuries in the emergency department date: 2018-06-27 words: 3070 flesch: 56 summary: Iontophoresis: as a new treatment modality in the management of acute soft tissue injuries in the emergency department Kristopher A. Brickman a, Tomas G. Zaciewski a , Rajiv Bahl a 1, Brian N. Fink a , Maureen P. Gibbons a , Ramzi S. Sidani a , Anthony N. Audino a , Joseph J. Ryno a , Daniel Z. Adams a , and Austin R. Wellock a aUniversity of Toledo Health Science Campus, Toledo, OH 43614 Background: Iontophoresis utilizes a transcutaneous process to deliver charged medication to a localized area of injury via an elec- trical current to remedy pain symptoms. The current ED standard of care for treating acute soft tissue injuries is immobi- lization and use of non-steroidal anti-inflammatory drugs (NSAIDs). keywords: control; group; injuries; iontophoresis; pain; study; treatment cache: translation-101.pdf plain text: translation-101.txt item: #3 of 204 id: translation-102 author: Brown, Megan M; Redfern, Roberta E; McPhee, Michael D title: Relationship between compliance to quality indicators, volume, and outcomes in pancreatic cancer resection in a community hospital setting date: 2018-06-27 words: 4391 flesch: 46 summary: To assess compliance, quality indicators applying to surgical treatment of pancreatic cancer patients were identified from those put forth by Bilimoria et al in 2009 (11). Further study of the clinical relevance of pancreatic cancer quality indicators is warranted. keywords: cancer; care; indicators; mortality; outcomes; patients; quality; survival; volume cache: translation-102.pdf plain text: translation-102.txt item: #4 of 204 id: translation-103 author: Menezes, Krishe; Deogaonkar, Milind; Bajpai, Vatsal title: Vim stimulation as a predictor of response to deep brain stimulation in patients of severe tremor undergoing dual stimulation date: 2018-06-27 words: 3578 flesch: 58 summary: Additions consist of stimulation of an additional nucleus e.g. If a patient has had Vim stimulation then an addition would consist of Vim + Raprl stimulation (See Fig. 1 below). We also conclude that for severe es- sential tremor, Raprl stimulation showed a better response than Vim stimulation. keywords: patients; raprl; response; stimulation; tremor; vim cache: translation-103.pdf plain text: translation-103.txt item: #5 of 204 id: translation-104 author: Shukla, Vipul; Asp, Alex; Saltzman, Barbara; Duggan, Joan title: Survey of health care student attitudes towards transgender health care education date: 2018-06-27 words: 3245 flesch: 50 summary: Survey of health care student attitudes towards transgender health care education Vipul Shukla a, Susan Dundas a , Alex Asp a , Barbara Saltzman a , and Joan Duggan a 1 aUniversity of Toledo Health Science Campus, Toledo, OH 43614 Background: This study assessed health care trainees percep- tions of their education regarding transgender health care issues and personal and professional comfort level with the provision of transgender health care. Despite this pressing need, this survey showed that educational hours devoted to transgender health care and direct patient contact with transgender patients remain limited for health care students across professional schools. keywords: care; education; health; medical; patients; students; transgender cache: translation-104.pdf plain text: translation-104.txt item: #6 of 204 id: translation-199 author: Durinka, Joel B.; Ortiz, Jorge title: Fate of Poster Abstracts Presented at the 2009 American College of Surgeons Clinical Congress date: 2017-06-27 words: 4320 flesch: 55 summary: After a review of the literature covering meetings from 2000- 2009, publication rates of meeting abstracts have been reviewed for different medical specialties, such as orthopedics, urology, anesthe- sia, surgery, pediatrics, oncology, emergency medicine, radiology, and ophthalmology. The full-length manuscript publication rate of meeting abstracts not only illustrates the quality of research conducted by an institu- tion’s investigators but also portrays the activity and reputation of a particular scientific meeting and its society members. keywords: abstracts; american; impact; journal; meeting; poster; publication; rate; studies; study; university cache: translation-199.pdf plain text: translation-199.txt item: #7 of 204 id: translation-200 author: Jankun, Jerzy; Redfern, Roberta; Sabharwal, Arjun title: Editorial: what editors welcome date: 2018-06-27 words: 771 flesch: 50 summary: In the 20th century investment in medical sciences and public health resulted in an unprecedented improvement in the health and wellbeing of people. Translation; The University of Toledo Journal of Medical Sci-ences, online journal, launched a few years ago by UT, is accept- ing again papers in all aspects of medical sciences in four different categories: (i) original articles reporting results of basic or clinical research; (ii) case reports; (iii) reviews; (iv) and editorials. keywords: health; medical; toledo cache: translation-200.pdf plain text: translation-200.txt item: #8 of 204 id: translation-201 author: Karipineni, Farah; Parsikia, Afshin; Chang, PoNan; Pang, John; Campos, Stalin; Khanmoradi, Kamran; Zaki, Radi; Ortiz, Jorge title: Dispelling the myth of Asian homogeneity: Improved outcomes of Chinese Americans after kidney transplantation date: 2022-12-20 words: 4249 flesch: 54 summary: Perioperative wound infection prophylaxis UTJMS 10:e1-e7 Karipineni et al 10.46570/utjms.vol10-2016-201 4 ©2022 UTJMS Chinese Other Asians Whites (n=37) (n=54) (n=346) (n=437) p-value 13.9 (6) 15.1 (6.9) 14 (7.4) 14.1 (7.2) 0.640 37.5 (36.2) 31.8 (19.3) 37.3 (19.6) 36.6 (21.5) 0.235 1.5 (1) 1.9 (1.9) 1.7 (0.9) 1.7 (1.2) 0.299 10.9 (26.3) 11.9 (29.7) 14.7 (30.2) 14 (29.7) 0.655 1 (0.4) 1.1 (0.5) 1.1 (1.1) 1.1 (1) 0.935 4 (10.8) 3 (5.6) 15 (4.3) 22 (5) 0.227 0.095 0 1 Chinese subjects demonstrate better patient survival at one year than Whites and non-Chinese Asians despite fewer live donors. keywords: asians; chinese; graft; kidney; outcomes; patients; renal; study; subgroups; survival; transplantation; whites cache: translation-201.pdf plain text: translation-201.txt item: #9 of 204 id: translation-202 author: Durinka, Joel B.; Wenzel, Tyler; Ortiz, Christopher; Choi, Lynn; Ortiz, Jorge title: Fate of Abstracts Presented at the 2007-2009 Americas Hepato-Pancreato-Biliary Association Meetings date: 2018-06-27 words: 4158 flesch: 55 summary: Full text publication rates of studies presented at an international emergency medicine scientific meeting. Publication rates of meeting abstracts have been reviewed in orthopedics, urology, anesthesia, surgery, pediatrics, on- cology, emergency medicine, transplantation, radiology, and ophthal- mology. keywords: abstracts; articles; journal; meeting; presentations; publication; rates; research; studies; study; text cache: translation-202.pdf plain text: translation-202.txt item: #10 of 204 id: translation-204 author: McGinnis, Ronald title: New Opportunities For Research Publication date: 2018-06-27 words: 369 flesch: 31 summary: Medical  schools  around  the  world  are   adopting  this  concept  to  facilitate  publication   resulting  from  early  research  involvement  of  students   and  the  transition  to  academic  medicine  of  residents   and  fellows.                   I  would  like  to  congratulate  the  Editorial  Staff  for   launch  of  UT’s  new  online  journal,  Translation:  The  University  of  Toledo  Journal  of  Medical   Sciences.   keywords: research cache: translation-204.pdf plain text: translation-204.txt item: #11 of 204 id: translation-205 author: Perz, Sarah K.; Tenbrink, Patrick M; Haselhuhn, Gregory H. title: Bladder Wall Calcification Following Transurethral Resection of Bladder Tumor and Intravesical Mitomycin C Instillation date: 2018-06-27 words: 2347 flesch: 45 summary: In rarely reported instances, the use of intravesical mitomycin C appears to have caused bladder wall calcification. In rarely reported instances, the use of intravesical mitomycin C ap- peared to cause bladder wall calcification (2-4). keywords: bladder; calcification; mitomycin; patient; resection; wall cache: translation-205.pdf plain text: translation-205.txt item: #12 of 204 id: translation-240 author: Roberts, Kasey; Buchenroth, Britta; Novi, Joseph title: Chronic Uterine Dehiscence Secondary to Genitourinary Tuberculosis: A Case Report date: 2018-09-28 words: 1625 flesch: 53 summary: In reporting this unexpected case of likely GU TB, we hope to have highlighted the importance of keeping the disease on the differential for cases that present similarly. One study examining the presenting complaints of 44 Sudanese women with pelvic TB found that 80% of affected women complained of chronic pelvic and lower abdominal pain, 48% of dyspareunia, 40% of infertility, 28% of menstrual dysfunction, and 20% of dys- menorrhea (1). keywords: case; dehiscence; pelvic cache: translation-240.pdf plain text: translation-240.txt item: #13 of 204 id: translation-241 author: Wang, Xin; Prince, Laura; Rattan, Juhi; Swartz, Neal L.; Shukla, Vipul; Durham, Tory A.; Biehn, Tracey L.; Drue, Jennifer L.; Ramachandran, Gowri; Sutu, Christine; Benton, Amber J.; Luckoski, John L.; Ding, Andrew; Tamburrino, Marijo B. title: Civilian Social Support and Posttraumatic Stress Disorder Symptoms among National Guard Members date: 2018-09-28 words: 3691 flesch: 51 summary: Unlike intensive studies in active duty military personnel, fewer studies have examined the role of social support in National Guard mem- bers, and civilian social support is rarely investigated in these limited studies. In addition to unit support, the influence of civilian social support was also considered a potent buffer for PTSD symptoms. keywords: guard; health; members; military; national; ptsd; soldiers; stress; support; symptoms cache: translation-241.pdf plain text: translation-241.txt item: #14 of 204 id: translation-242 author: Yousif, Gheith; Phelps, Kevin; Gotfried, Robert title: The Importance of Following ACC/AHA Cholesterol Guidelines 2013 by Residents’ Physicians to Reduce Atherosclerotic Cardiovascular Disease in Different Populations Gheith Yousif, MD/MBChB, Kevin Phelps, DO., Robert Gotfried, DO. University of Toledo/Family Medicine Department date: 2018-09-28 words: 3471 flesch: 54 summary: This means that our residents are diligent when prescribing statins for high risk patients, but still there is room for improvement. The charts reviewed were selected from among patients cared for by Family Medicine residents at the University of Toledo Family Medicine Center, Glendale Medical East Clinic (GME). keywords: ascvd; guidelines; patients; residents; risk; statin; study; year cache: translation-242.pdf plain text: translation-242.txt item: #15 of 204 id: translation-243 author: Brewer, Shawn P.; Jankun, Jerzy title: Bifunctional inhibitors of urokinase and metalloproteinase-9 for cancer treatment - in silico evaluation date: 2018-09-28 words: 4976 flesch: 52 summary: Consequently human clini- cal studies were designed inhibiting urokinase or MMPs, but these 8 utdc.utoledo.edu/Translation Brewer et al. target specific inhibitors producing mixed results (64-67). Towle MJ, et al. (1993) Inhibition of urokinase by 4-substituted benzo[b]thiophene-2-carboxamidines: an important new class of selective synthetic urokinase inhibitor. keywords: activator; activity; cancer; et al; hybrid; inhibitor; jankun; journal; matrix; mmp-9; oncology; plasminogen; structure; upa; urokinase cache: translation-243.pdf plain text: translation-243.txt item: #16 of 204 id: translation-250 author: Perz, Sarah; Suttle, Timothy; Sindhwani, Puneet title: Management of Ureters Involved in Inguinal Hernias date: 2018-10-17 words: 3069 flesch: 48 summary: Ureteral inguinal hernia: an uncommon trap for general surgeons, BMJ Case Rep., 1, 1-5. 5. hernia CT ureteral stent herniorraphy ureteral calculus no ureteral injury renal insufficiency CT large hernia, renal failure ureteral stent herniorrhaphy no ureteral injury Perz et al. UTJMS 2018 keywords: hernia; hydronephrosis; injury; patients; renal; stent; ureter cache: translation-250.pdf plain text: translation-250.txt item: #17 of 204 id: translation-266 author: Garcher, Damian title: Functional Castration from Blunt-force Trauma to Motorcycle Gas Tank from a Car-versus-motorcycle MVA date: 2019-06-10 words: 1747 flesch: 57 summary: First reported in 1818 as a crush injury from a wagon wheel, testicular trauma is now well-described in modern literature (2). Although in general a rare entity in blunt trauma situations, testicular trauma is often associ- ated with motorcycle collisions (3, 4). keywords: injuries; injury; motorcycle; testicular; trauma cache: translation-266.pdf plain text: translation-266.txt item: #18 of 204 id: translation-269 author: Koffman, Boyd title: Migraine Headache associated with Multiple Sclerosis: Results from the Nationwide Inpatient Sample date: 2021-04-25 words: 3342 flesch: 60 summary: Objecctives: In this study, we investigated headache prevalence and association in MS patients. The prevalence of migraine among MS patients (7%) was significantly higher than the control group (2.8%). keywords: age; data; headache; migraine; patients; prevalence; sclerosis; study cache: translation-269.pdf plain text: translation-269.txt item: #19 of 204 id: translation-278 author: Fatima, Rawish; Aziz, Muhammad; Khader, Yasmin; Lee-Smith, Wade; Altorok, Nezam title: Safety and Efficacy of Anifrolumab in Systemic Lupus Erythematosus: Systematic Review with Network Meta-analysis date: 2023-05-03 words: 449 flesch: 45 summary: Secondary outcomes assessed included overall flares at 52 weeks, adverse events and serious adverse events. May 05; 11(1):e1-e2 Safety and Efficacy of Anifrolumab in Systemic Lupus Erythematosus: Systematic Review with Network Meta- analysis Rawish Fatima1*, Muhammad Aziz, MD2, Yasmin Khader3, Wade Lee-Smith4, Nezam Altorok, MD1 1Division of Rheumatology, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Division of Gastroenterology, Diabetes, and Metabolism, Department of Medicine, The University of Toledo, Toledo, OH 43614 3Division of Internal Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 4Department of University Libraries, College of University Libraries, The University of Toledo, Toledo, OH 43614 keywords: toledo; university cache: translation-278.pdf plain text: translation-278.txt item: #20 of 204 id: translation-285 author: Yousif, Gheith title: Critical Hypomagnesemia and Seizure Induced by Chronic Use of Proton Pump Inhibitors (PPIs) date: 2019-06-12 words: 2017 flesch: 48 summary: Critically low magnesium level may lead to fatal seizure activity, which could lead to death if went undi- agnosed. Despite resolution of her vomiting and diarrhea, she continued to have low magnesium levels. keywords: hypomagnesemia; level; magnesium; patient; ppis; proton; use cache: translation-285.pdf plain text: translation-285.txt item: #21 of 204 id: translation-299 author: Fumo, David Eugene title: Boondoggled: A Case Report of Arts and Crafts Gone Wrong date: 2019-07-23 words: 2192 flesch: 54 summary: For the urologist, it is critical to recognize the mental health is- sues portended by urethral foreign body insertion, and take the appropriate steps to address the underlying problem. For the urologist, it is critical to recognize the mental health issues portended by urethral foreign body insertion, and take the appropriate steps to address the underlying problem. keywords: bladder; bodies; body; case; insertion; patient; urol cache: translation-299.pdf plain text: translation-299.txt item: #22 of 204 id: translation-301 author: Jankun, Jerzy title: Richard Hart (1947-2018) date: 2019-06-04 words: 876 flesch: 51 summary: For many years Richard was a long-time volunteer at McGill University and was a founding member of the Faculty of Science Advisory Board (now the Science Campaign Committee). Richard came from New Zealand through Europe to Canada to undertake doctoral studies in chemistry at McGill University, Montreal. keywords: hart; research; richard; university cache: translation-301.pdf plain text: translation-301.txt item: #23 of 204 id: translation-317 author: Lubarsky, Daniel title: Streptococcus Pneumoniae Urinary Tract Infection in 3-Year-Old Girl date: 2019-12-03 words: 1708 flesch: 47 summary: While a common cause of upper respiratory infections, the current Infectious Diseases Society of America (IDSA) guidelines on urinary tract infections do not cite Streptococcus pneumoniae as a cause for UTIs in children (2). While a common cause of upper respiratory infections, the current Infectious Dis- eases Society of America (IDSA) guidelines on urinary tract infec- tions (UTIs) do not cite Streptococcus pneumoniae as a cause for UTIs in children. keywords: children; patient; pneumoniae; streptococcus; utis cache: translation-317.pdf plain text: translation-317.txt item: #24 of 204 id: translation-318 author: Levine, Jason Andrew; Hovsepyan, Karen; Lubarsky, Daniel; Mukundan, Deepa; Ruddy, Jennifer title: Streptococcus Intermedius Lung Abscess in a 17-year-old Male date: 2019-12-03 words: 2225 flesch: 47 summary: The most common type of Streptococcus intermedius infection in the pediatric population is a sinusitis (12), and it was presented that hematogenous dissemination is the main mechanism in children. This proposition was supported by the fact that in one third of cases with Streptococcus intermedius abscesses, blood culture was found to be positive (7, 12). keywords: case; empyema; infection; intermedius; patient; smoking; streptococcus cache: translation-318.pdf plain text: translation-318.txt item: #25 of 204 id: translation-319 author: Yahaya, Tajudeen title: Role of Epigenetics in the Pathogenesis and Management of Type 2 Diabetes Mellitus date: 2019-12-02 words: 9750 flesch: 59 summary: Starvation can modify placenta epigenome through gene methylation or modification of miRNAs associated with genes necessary for fetal development, nutrient transfer, and disease pre- vention (94). An experiment performed by Kameswaran et al. keywords: adipose; cells; changes; diabetes; diseases; dna; dna methylation; doi; epigenetics; epigenome; et al; exercise; expression; gene; histone; human; insulin; methylation; muscle; obesity; pathogenesis; studies; study; t2 dm; tissue; type cache: translation-319.pdf plain text: translation-319.txt item: #26 of 204 id: translation-331 author: Alafyouni, Maisa; Huang, Derrick; Jones, Shanna; Kleiman, Scott title: Acute Bilateral Ischemic Stroke in a Young Adult without risk factors date: 2019-12-03 words: 2405 flesch: 55 summary: Although both groups share identical modifiable risk factors, heart disease such as atrial fibrillation and diabetes mellitus is more prevalent in patents whereas dyslipidemia and smoking are more prevalent in younger stroke patients (10). The case highlights the need for a high index of suspicion in younger CVA patients whose greater potential for atypical presentations may compromise time-sensitive treatments. keywords: cva; ischemic; normal; patients; stroke cache: translation-331.pdf plain text: translation-331.txt item: #27 of 204 id: translation-332 author: Salari, MD, Bijan; Rospert, Daniel; Boyle, MD, Emmett; Sindhwani, MD, Puneet; Emmert, MD, Gregor title: Metastatic Breast Cancer to the Bladder date: 2020-05-06 words: 1366 flesch: 53 summary: Occasion- ally, metastatic breast cancer can present itself with obstructive uropathy from a proposed retroperitoneal spread. We present a case of a 77 year old Caucasian female who was found to have acute urinary obstruction from metastatic breast cancer to the bladder. keywords: bladder; breast; cancer; carcinoma cache: translation-332.pdf plain text: translation-332.txt item: #28 of 204 id: translation-333 author: Shermis, Robin B; Redfern, Roberta E; Bazydlo, John; Naimy, Gabriel; Kudrolli, Haris; Chen, John title: Performance of Molecular Breast Imaging as an Adjunct Diagnostic Tool date: 2019-12-02 words: 4144 flesch: 54 summary: Duijm LE, Guit GL, Zaat JO, Koomen AR, & Willebrand D (1997) Sensitivity, speci- ficity and predictive values of breast imaging in the detection of cancer. The pos- itive reference standard was defined as histopathologic diagnosis of breast cancer, whereas negative reference standard was defined as negative biopsy results following index MBI exam or negative follow-up mammographic examination occurring at least 330 days following index MBI exam. keywords: breast; cancer; imaging; journal; mammography; mbi; negative; results; women cache: translation-333.pdf plain text: translation-333.txt item: #29 of 204 id: translation-339 author: Kheireldin, Rowida title: A Case Report of Clobazam Toxicity Related to Cannabidiol and Clobazam Drug-drug Interaction date: 2019-12-03 words: 1894 flesch: 55 summary: We recom- mend obtaining baseline Clobazam level before starting CBD and monitoring Clobazam levels every two weeks for a few months to avoid side effects and toxicity. We also rec- ommend monitoring Clobazam levels every two weeks for the first few months to avoid side effects and toxicity. keywords: cbd; clobazam; drug; levels; patient cache: translation-339.pdf plain text: translation-339.txt item: #30 of 204 id: translation-343 author: Redfern, Roberta; Brown, Megan; Izsak, Eugene title: Medical Clearance Prior to Psychiatric Evaluation in a Tertiary Pediatric Emergency Department: Value and Cost Analysis date: 2020-05-05 words: 4367 flesch: 50 summary: Early studies of the utility of medical clearance for adult psychiatric pa- tients in the ED suggested that 63% of psychiatric patients had some underlying organic disease, discovered by this type of testing (3,4). Several other studies have also concluded that routine laboratory screening of psychiatric patients in the ED is of little value, and that most abnormalities can be anticipated in the patient’s history and physical (2,7-10). keywords: clearance; department; drug; emergency; medical; patients; psychiatric; results; tests cache: translation-343.pdf plain text: translation-343.txt item: #31 of 204 id: translation-344 author: Beeson, Rachel; Stefanopoulos, Stavros; Daniel Rapport; Jorge Ortiz title: Kidney Transplant Recipient with Conversion Disorder Treated with Electroconvulsive Therapy date: 2020-05-19 words: 2653 flesch: 53 summary: ECT may be considered in patients with severe conversion disorder with a previous history of successful treatment. Conclusion ECT in the treatment of severe conversion disorder may be ap- propriate and result in good clinical outcome. keywords: case; catatonia; conversion; disorder; ect; patient; treatment cache: translation-344.pdf plain text: translation-344.txt item: #32 of 204 id: translation-346 author: Talbot, Benjamin; Jankun, Jerzy title: Specific inhibitors of urokinase plasminogen activator for treatment of cancers; In silico approach date: 2020-05-06 words: 4459 flesch: 58 summary: However, for successful targeted anticancer therapy it is essential to find specific uPA inhibitors and to protect normal function of tPA. Thus, for successful targeted anticancer therapy, it is imperative to find specific uPA inhibitors, and at the same time protect normal function of other serine proteases of analogous structures, such as tPA. keywords: activator; activity; amiloride; binding; inhibitors; plasminogen; pocket; specificity; structure; tpa; upa; urokinase cache: translation-346.pdf plain text: translation-346.txt item: #33 of 204 id: translation-347 author: Alkully, Turki; Hensley, Sandra ; Khuder, Sadik; Luke, Naveena; Ruzieh, Mohammed; Duggan, Joan title: PICC line associated blood stream infections: an analysis of host and device factors date: 2021-01-26 words: 4526 flesch: 55 summary: A statistical anal- ysis of PICC CLABSI risk factors compared to matched con- trols was performed. There was significant correlation with PICC line infection and the following use of de-clotting agents (OR:0.22, 95% [CI:0.08-0.57], P=0.0009), complication after PICC line insertion (OR:4.22, 95%CI keywords: clabsi; factors; infection; insertion; line; picc; risk; study; use cache: translation-347.pdf plain text: translation-347.txt item: #34 of 204 id: translation-360 author: Gotfried, Robert title: Ehrlichiosis in Southern Ohio: Two case reports and a review of the literature date: 2023-07-06 words: 5304 flesch: 55 summary: Southern Ohio in particular, has been identified as having a high preponderance of E. chaffeensis infected ticks (8). While the clinical manifestations of E. chaffeensis infection are nonspecific, laboratory abnormalities provide important diagnostic clues. keywords: borne; cases; chaffeensis; disease; ehrlichiosis; fever; hme; mmol; patients; tick; treatment cache: translation-360.pdf plain text: translation-360.txt item: #35 of 204 id: translation-361 author: Jankun, Jerzy title: COVID-19 pandemic; transmembrane protease serine 2 (TMPRSS2) inhibitors as potential drugs. date: 2020-04-24 words: 4054 flesch: 52 summary: PAI-1 is hu- man in origin and engineered forms with an extended half-life were developed and could be an attractive addition to the ex- isting TMPRSS2 inhibitors. They also emphasize the importance of TMPRSS2 protease inhibition. keywords: aprotinin; covid-19; influenza; inhibitor; plasminogen; protease; replication; serine; tmprss2; virus cache: translation-361.pdf plain text: translation-361.txt item: #36 of 204 id: translation-389 author: Kheireldin, Rowida; Imdad, Sameer; Ostwani, Waseem title: TANGO-2 with Severe and Prolonged Rhabdomyolysis in a 2-year Old Male TANGO-2 with Severe and Prolonged Rhabdomyolysis in a 2-year Old Male with Human metapneumovirus Infection. A case report and literature review. : TANGO-2 date: 2020-08-13 words: 2067 flesch: 52 summary: During a metabolic crisis, some patients may develop acute rhabdomyolysis. Rowida Kheireldin a Sameer Imdad a Waseem Ostwani b Coresponding author(s): waseem.ostwanimd@promedica.org aDivisions of Pediatrics, Department of Pediatrics, University of Toledo, College of Medicine and Life Sciences, Toledo, OH 43614, USA, and bDivisions of Critical Care Medicine, Department of Pediatrics University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA We report a unique case of prolonged acute rhabdomyolysis in a 2-year-old male with known TANGO-2 mutation with delayed peak in creatinine kinase levels secondary to human metapneu- movirus infection. keywords: day; patients; rhabdomyolysis cache: translation-389.pdf plain text: translation-389.txt item: #37 of 204 id: translation-408 author: Yahaya, Tajudeen; Oladele, Esther; Nnochiri, Kelechi; Abdullahi, Haliru; Nathaniel, Josephine title: Genetic Susceptibility to Coronavirus Disease 19 (COVID-19): A Review date: 2021-06-23 words: 6160 flesch: 60 summary: When the patients were grouped according to blood types, individuals with type A had a higher chance of developing severe respiratory failure compared with type O (21). In another study, a retrospective cohort study of SARS-CoV-2 patients in three hospitals in China also associated the prevalence and severity of the virus with blood types. keywords: ace2; blood; coronavirus; cov-2; covid-19; disease; gene; hla; infection; protein; sars; susceptibility; tmprss2; type cache: translation-408.pdf plain text: translation-408.txt item: #38 of 204 id: translation-414 author: Aouthmany, Shaza; Horn, Tymon ; Howe, Michelle; Kakish , Edward ; Kakish, Alana ; Pillai , Mahesh ; Jones, Corion title: Does Patient Self-Awareness Predict Ankle Fractures? date: 2021-01-28 words: 3348 flesch: 61 summary: How- ever, considering rising healthcare costs and radiation exposure, there is a need to improve the current yield of ankle X-rays and develop better tools to aid in assessing ankle fractures. The criteria for ordering ankle X-ray is a topic that warrants further conversation (6). keywords: ankle; fracture; injuries; patients; ray; study; table cache: translation-414.pdf plain text: translation-414.txt item: #39 of 204 id: translation-415 author: Shao, Qin; Thompson, Gerard; Thompson, Amy title: COVID-19 Risk Factor Identification based on Ohio Data date: 2020-12-21 words: 4319 flesch: 68 summary: According to the p- values in Table 5, the effects of age levels are significantly different, except for the rst two age levels, 0 - 19 and 20 - 29 for which mor- tality probabilities are not statistically significantly different. There is also growing evidence to suggest that while equal numbers of men and women develop COVID-19, when looking across age groups, males are more likely to die with the exception of 8 utdc.utoledo.edu/Translation Shao et al. the age group of 80+ where there are significantly more female than male deaths occurred. keywords: age; case; count; covid-19; data; death; gender; mortality cache: translation-415.pdf plain text: translation-415.txt item: #40 of 204 id: translation-417 author: Jessica Allman; Mohamad Moussa; Shivam Shah; Madison Rectenwald; Casey Pollard; Jake Goliver title: Virtual COVID-19 Clinical Teaching Session:: A Substitute for ‘Sheltered in Place’ MedicalStudents date: 2020-11-19 words: 3142 flesch: 49 summary: The ability to adapt in real time to changing clinical guidelines is a skill that clinical students need to emulate on their return to the clini- cal setting. While physicians, residents, and medical students would all benefit from hands-on training on the medical manage- ment and stabilization of COVID-19 patients, this is not feasible due to risk of transmission and spread of the virus. keywords: confidence; covid-19; emergency; medical; session; students; survey cache: translation-417.pdf plain text: translation-417.txt item: #41 of 204 id: translation-420 author: Agnew, Matthew; Renno, Anas; Mahmood, Asif title: Page Kidney: A Secondary Cause of Hypertension date: 2021-03-03 words: 1574 flesch: 49 summary: Page kidney can be suspected in patients with resis- tant hypertension and whose history reveals recent urologic manip- ulation. Page kidney is a rare cause of secondary hypertension in patients but can be considered in those with a recent history of nephrolithiasis and extracorporeal shock wave lithotripsy. keywords: hypertension; kidney; page; patient cache: translation-420.pdf plain text: translation-420.txt item: #42 of 204 id: translation-421 author: Giffen, Zane; Ezzone, Austin; Ekwenna, Obi title: A Retrospective Cohort Analysis of Robotic Stapler Use in Robotic-Assisted Donor Nephrectomy date: 2021-01-27 words: 2538 flesch: 54 summary: Conclusions: Robotic stapler use is safe and effective in robotic-assisted donor nephrectomy, even in cases of complex renal hilar anatomy. Further research on prevalence of robotic stapler use is needed to quantify the asso- ciated complication rate. keywords: cases; donor; laparoscopic; robotic; stapler cache: translation-421.pdf plain text: translation-421.txt item: #43 of 204 id: translation-450 author: Maier, Jacob; Rapport, Daniel ; McCormick, Alex; Lewis, Chandani title: Oral Valproate Sodium as an Alternative to Benzodiazepine in the Treatment of Catatonia- A Case Report date: 2021-02-24 words: 2151 flesch: 55 summary: A literature search yielded a case of catatonia that was success- fully treated with sodium valproate, so we decided to treat him with oral sodium valproate. We present a case where oral sodium valproate was used successfully for both acute and long-term catatonic treatment. keywords: case; catatonia; patient; sodium; treatment; valproate cache: translation-450.pdf plain text: translation-450.txt item: #44 of 204 id: translation-462 author: Nguyen, Hanh ; Shao, Qin title: Risk Identification and Prediction for COVID-19 Mortality: Risk Identification and Prediction for COVID-19 Mortality date: 2021-09-01 words: 4205 flesch: 66 summary: For example, how infectiousness of COVID-19 has been changing due to interventions (15), such as social distancing and curfew; it is possible that more and more eas- ily accessible tests have led to large case counts recently; more and more effective treatments could have been contributing to the reduc- Submitted: 03/23/2021, published: 08/31/2021. Case Fatality Rates rt and π t keywords: case; cfr; covid-19; daily; data; death; model cache: translation-462.pdf plain text: translation-462.txt item: #45 of 204 id: translation-463 author: Menon, Bindu; Patel, Radha; Kovacs, Kelly; Prevette, Christopher ; Chen, Tian; Matus, Coral D title: Integration of E-learning into the Physiology Education of Medical Students in their Pre-clinical Curriculum : E-learning in Medical Phyiology Education date: 2021-07-01 words: 2832 flesch: 51 summary: Once we have obtained more comprehensive data, it will provide more critical information about the utility of LMs in student learning. The new integrated method was introduced to the second-year (M2) class of medical students in their foundational science curriculum (class size, 177) during the gastrointestinal (GI) physiology sessions. keywords: class; learning; lms; mastery; medical; skills; students cache: translation-463.pdf plain text: translation-463.txt item: #46 of 204 id: translation-488 author: Eric Medrano; Jake Goliver title: Suspected Compartment Syndrome and Rhabdomyolysis after “Pseudoephedrine” Use: A Case Report date: 2021-08-18 words: 1911 flesch: 50 summary: Although the most common cause of compartment syndromes are secondary orthopedic causes such as lower extremity fractures there are known docu- mented toxicological causes. However, it is incred- ibly rare to see an association with pseudoephedrine overdose and rhabdomyolysis and compartment syndrome. keywords: case; compartment; emergency; patient; pseudoephedrine; rhabdomyolysis; syndrome cache: translation-488.pdf plain text: translation-488.txt item: #47 of 204 id: translation-515 author: Lombardi, Conner; Glosser, Logan; Knauss, Hanna; Norwood, Teanya; Berry, Julia; Ekwenna, Obinna title: Impact of Social Determinants of Health on Chronic Kidney Disease: A Review of Disparities in Renal Transplantation: Socioeconomic Impact on Kidney Transplant date: 2021-11-22 words: 4497 flesch: 54 summary: The five-year survival in patients with kidney transplant is 86%, compared to 53% in hemodialysis.(9) As such, kidney transplant has become a target for health incentives. To improve access to kidney transplants, there is a need to iden- tify and address factors outside of genetic predisposition that influ- ences ESRD treatment. keywords: access; care; ckd; dialysis; disease; disparities; esrd; health; kidney; kidney transplant; patients; transplant; transplantation; treatment cache: translation-515.pdf plain text: translation-515.txt item: #48 of 204 id: translation-520 author: Keener, Myles; Sturges, Rebecca; Becker, Kathryn; Gifford, Connor; Alexander, Christopher; Schroeder, Jason; Smithason, Saksith title: pdf Limits to Neurosurgical Care for an Undocumented Immigrant in the United States: A Case Report date: 2021-11-18 words: 2791 flesch: 49 summary: Correspondingly, UIs report worse access to health care as well as poorer health out- comes compared with other populations in the US (7). Without legal access to health insurance, accessing health care in the US requires that undocumented immigrants personally absorb the costs of care or pursue free healthcare through either the emergency department or a free private clinic (3, 8). keywords: access; arachnoid; care; cyst; health; healthcare; immigrants; patient; united cache: translation-520.pdf plain text: translation-520.txt item: #49 of 204 id: translation-521 author: Jonathan Doan; Dr. Irfan Sheikh; Ajaz Sheikh; Dr. Mehmood Rashid title: Clinical Application and Initial Response of Seizures and Epilepsy in the Hospital Setting – An Educational Tool for Medical Students: Medical Student Clinical Epilepsy Education date: 2022-12-20 words: 2245 flesch: 47 summary: Methods: 3rd year medical students rotating on the neurology clerkship at University of Toledo were divided into two groups - if they received a resident-led didactic lecture or not. Results: 3rd year medical students who received the resident-led didactic lecture on seizure and epilepsy clinical application and initial management scored higher on average on the survey, with statistical significance (p<0.05) seen when asked to clinically identify a seizure and how to record a seizure event in the hospital setting. keywords: lectures; medical; resident; seizure; students cache: translation-521.pdf plain text: translation-521.txt item: #50 of 204 id: translation-522 author: Gifford, Connor; Norris, Jordan; Sheehan, Erin; Becker, Kathryn; Alexander, Christopher; Schroeder, Jason; Smithason, Saksith title: Case Report: Cerebral Edema and Tonsillar Herniation Leading to Brain Death After Cocaine Use in a Patient with End-Stage Renal Disease date: 2022-12-20 words: 2982 flesch: 54 summary: Blood cocaine levels can range from 0.1 to 24 mg/L following a single insufflation, demonstrating its wide range of toxicity. We present the first known case of a non-compliant dialysis patient who suffers cerebral edema, tonsillar herniation, and brain death following cocaine use. keywords: blood; brain; cocaine; dialysis; edema; epub; patient; pmid; pubmed; use cache: translation-522.pdf plain text: translation-522.txt item: #51 of 204 id: translation-523 author: DelCimmuto, Nicholas R; Al-Chalabi, Mustafa; Beran, Azizullah; Devarasetty, Pratyush Pavan; Mhanna, Asmaa; Sheikh, Ajaz title: Clinical Characteristics, Management, and Outcomes of CLIPPERS:: A Comprehensive Systematic Review of 140 patients from 100 Studies date: 2023-05-03 words: 341 flesch: 38 summary: May 05; 11(1):e1-e1 Clinical Characteristics, Management, and Outcomes of CLIPPERS: A Comprehensive Systematic Review of 140 patients from 100 Studies Nicholas R. DelCimmuto1*, Mustafa Al-Chalabi2, Azizullah Beran, MD3; Pratyush Pavan Devarasetty1, Asmaa Mhanna, MD3, Ajaz Sheikh, MD2 1College of Medicine and Life Sciences, The University of Toledo, Toledo, OH 43614 2Department of Neurology, The University of Toledo, Toledo, OH 43614 3Division of Internal Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 The University of Toledo Translation Journal of Medical Sciences Rheumatology Abstract, Department of Medicine Research Symposium UTJMS 2023 keywords: toledo; university cache: translation-523.pdf plain text: translation-523.txt item: #52 of 204 id: translation-526 author: Lewis, Chandani; Brennan, Christine title: “Clozapine & Valbenazine for Treatment of Tardive Cervical Dystonia: A Case Report”: Tardive Cervical Dystonia date: 2023-07-06 words: 2613 flesch: 53 summary: This case illustrates the potential for clozapine plus valbenazine to treat tardive cervical dystonia. In this case report we present a 29-year-old African American male with a history of paranoid schizophrenia who developed tardive cervical dystonia after exposure to second generation antipsychotics. keywords: clozapine; dystonia; patient; symptoms; tardive; treatment; valbenazine cache: translation-526.pdf plain text: translation-526.txt item: #53 of 204 id: translation-550 author: Sadry, Payam; Magsi, Rayan; Ahmed, Maahum; Amsdell, Jennifer; Derani, Talal; Mahfooz, Naeem; Sheikh, Ajaz title: Symptomatic Intracranial Hypertension Secondary to Superior Vena Cava Thrombosis as the First Manifestation of Behçet’s Disease: ATYPICAL FIRST MANIFESTATION OF BEHCET’S date: 2023-07-06 words: 2354 flesch: 49 summary: Screening for large venous thrombosis using MRI/MRV and CTA in BD patients with elevated intracranial pressure is Figure 1. Some cases of young BD patients with cardiac involvement have been reported in geographical regions with high BD prevalence but are overall quite rare (2,11). keywords: behçet; disease; involvement; patient; thrombosis cache: translation-550.pdf plain text: translation-550.txt item: #54 of 204 id: translation-551 author: Magsi, Rayan; Ryan, Casey; Sheikh, Ajaz; Noor, Mariam; Mahfooz, Naeem title: Novel Gene Abnormality in Epilepsy with Myoclonic-Atonic Seizures (Doose Syndrome) date: 2023-07-06 words: 1950 flesch: 56 summary: [15] Joshi, C., Nickels, K., Demarest, S., et al. Results of an international Delphi consensus in epilepsy with myoclonic atonic seizures/Doose syndrome. Approximately 35-40% of first-degree relatives of patients also developed clinical seizures. keywords: doose; epilepsy; myoclonic; patient; seizures; syndrome cache: translation-551.pdf plain text: translation-551.txt item: #55 of 204 id: translation-594 author: Dimmerling, Taylor; Altattan, Mohamed; Altorok, Nezam title: Relapsing Polychondritis: A Case Report of the Use of Adalimumab in Steroid Dependent Disease date: 2023-05-03 words: 172 flesch: 16 summary: May 05; 11(1):e1-e1 Relapsing Polychondritis: A Case Report of the Use of Adalimumab in Steroid Dependent Disease Taylor Dimmerling, MD1*, Mohamed Altattan, MD2, Nezam Altorok, MD2 1Division of Internal Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Division of Rheumatology, Department of Medicine, The University of Toledo, Toledo, OH 43614 *Corresponding author: taylor.dimmerling@utoledo.edu Published: 05 May 2023 Introduction: Conclusion: Biologic therapy with TNF-alpa inhibition can be considered in patients with refractory or steroid dependent relapsing polychondritis. keywords: toledo cache: translation-594.pdf plain text: translation-594.txt item: #56 of 204 id: translation-599 author: Heck, Holly; Tipton, Claire; Becker, Kathryn; Creeden, Justin; Schroeder, Jason; Larder, Cristin; Haak, Peterson; Pyles, Bryan; Eisenmann, Kathryn title: Impact of COVID-19 on Clinical Productivity at the University of Toledo Medical Center Specialty Care Clinics date: 2023-07-06 words: 4395 flesch: 56 summary: % May -51.67% June -22.23% July -23.05% UTJMS 11(2):e1-e12 Heck et al 10.46570/utjms.vol11-2023-599 9 @2023 UTJMS Medicine Community Internal Medicine March -44.39% April -74.06 -44.21% April -87.79% May -35.83% June 28.33% July -1.01% Medicine Endocrinology March 12.82% April -20.80 keywords: april; care; covid-19; july; june; march; medicine; pandemic; relative; toledo; wave; wrvus cache: translation-599.pdf plain text: translation-599.txt item: #57 of 204 id: translation-620 author: Wang, Yongqing; Jun, John Y. title: Activation of the Transient Receptor Potential Ion Channel TRMP8 Mediates Upregulation 0f Profibrotic Genes, A New Pathway to Tissue Fibrosis date: 2023-05-03 words: 360 flesch: 44 summary: In this study, we evaluated TRPM8 expression, the effects of TRPM8 activation on fibroblast (FB) fibrotic gene expression, and intracellular signaling. Conclusion: Functional TRPM8 is expressed in human dermal FBs and enhanced expression was observed in SSc FBs and skin. keywords: toledo; trpm8 cache: translation-620.pdf plain text: translation-620.txt item: #58 of 204 id: translation-621 author: Wang, Yongqing; Kahaleh, Bashar title: Downregulation of Microrna-126 in Scleroderma is Associated with Epigenetically Mediated Nitric Oxide Synthase Repression and Enhanced Platelet/Endothelial Interaction date: 2023-05-03 words: 344 flesch: 35 summary: NOS3 expression levels were significantly reduced in SSc cells, Dnmt1 expression levels were significantly higher in SSc cells. Upregulation of MiR126 in SSc MVECs resulted in the reduction of Dnmt1 and upregulation of NOS3 expression levels, while the inhibition of MiR 126 expression levels in control MVECs resulted in decreased NOS3 levels and enhanced Dmnt1 levels. keywords: expression cache: translation-621.pdf plain text: translation-621.txt item: #59 of 204 id: translation-627 author: Davis, Samantha title: IgA Vasculitis Associated with COVID-19 Infection Successfully Treated with Corticosteroid Regimen without Relapse date: 2023-05-03 words: 329 flesch: 27 summary: Case: We report a 33-year-old male with COVID-19 infection two weeks before developing worsening palpable purpura for one week then severe abdominal pain, nausea, emesis, diarrhea, hematochezia, and arthralgia. Conclusion: This case demonstrates active COVID-19 infection precipitated biopsy-proven IgA vasculitis. keywords: iga; md1 cache: translation-627.pdf plain text: translation-627.txt item: #60 of 204 id: translation-628 author: Wang, Yongqing title: Vasopressin Modulates Endothelial and Fibroblast Gene Expression date: 2023-05-03 words: 332 flesch: 37 summary: NOS3 expression levels were significantly reduced in SSc cells, Dnmt1 expression levels were significantly higher in SSc cells. Upregulation of MiR126 in SSc MVECs resulted in the reduction of Dnmt1 and upregulation of NOS3 expression levels, while the inhibition of MiR 126 expression levels in control MVECs resulted in decreased NOS3 levels and enhanced Dmnt1 levels. keywords: expression cache: translation-628.pdf plain text: translation-628.txt item: #61 of 204 id: translation-633 author: Abugharbyeh, Aya; Khuder, Sadik; Kahaleh, Bashar title: Decreased Prevalence of Autoimmune Connective Tissue Diseases in Type 1 and Type 2 Diabetes date: 2023-05-03 words: 339 flesch: 53 summary: In patient with type 1 and type 2 diabetes mellitus (DM). Conclusion: The data demonstrates an inverse relation between SSc, lupus, and SS in patients with DM. keywords: type cache: translation-633.pdf plain text: translation-633.txt item: #62 of 204 id: translation-634 author: Abdelrahman, Ahmad; Alharbi, Abdulmajeed; Nesheiwat, Zeid; Grande, Robert title: Intermittent High Grade AV-Block and Atrial Flutter Associated with Lyme Carditis: : A Case Report date: 2023-05-03 words: 333 flesch: 41 summary: Lyme disease is the most common tick-borne infection caused by spirochetes in the Borreliacidal family. Lyme disease typically progresses in phases. keywords: lyme cache: translation-634.pdf plain text: translation-634.txt item: #63 of 204 id: translation-635 author: Abrahamian, Andrew; Burmeister, Cameron; Hejeebu, Srini title: Suspected Doxycycline Induced Acute Interstitial Nephritis date: 2023-05-03 words: 321 flesch: 25 summary: The patient’s presentation led to a relatively broad differential for acute kidney injury (AKI), which included contrast-induced nephropathy, vancomycin-induced nephrotoxicity, and interstitial nephritis secondary to antibiotic use. Interstitial nephritis associated with doxycycline use is poorly described in the literature, which delayed cessation of suspected offending agent. keywords: patient cache: translation-635.pdf plain text: translation-635.txt item: #64 of 204 id: translation-637 author: Abuhelwa, Ziad; Beran, Azizullah; Malhas, Saif-Eddin; Sayeh, Wasef; Sajdeya, Omar; Spencer, Caleb; Assaly, Ragheb title: Primary Esophageal Extra-Gonadal Yolk Sac Tumor Metastasized to the Liver date: 2023-05-03 words: 354 flesch: 46 summary: Discussion: Primary gastrointestinal germ cell tumors have been very rarely reported in the literature. No reported case of primary esophageal yolk sac tumor (YST) has been published yet in the literature. keywords: medicine; toledo cache: translation-637.pdf plain text: translation-637.txt item: #65 of 204 id: translation-638 author: Abuhelwa, Ziad title: Midostaurin in Advanced Systemic Mastocytosis: A Systematic Review and Meta-analysis date: 2023-05-03 words: 387 flesch: 40 summary: The most common subtype of advanced SM was SM associated with hematological neoplasm (59%) followed by aggressive SM (23.1%). Methods: We systematically searched the following databases: PubMed/MEDLINE, Embase, and Cochrane through February 02, 2022, to include all studies that assessed the effect of midostaurin on clinical outcomes of patients with advanced SM. keywords: medicine; toledo cache: translation-638.pdf plain text: translation-638.txt item: #66 of 204 id: translation-639 author: Aradhyula, Vaishnavi title: A Novel Lipidomics Approach to Predicting Pulmonary Hypertension in Human Heart Failure date: 2023-05-03 words: 358 flesch: 36 summary: Pulmonary venous and arterial serum samples were collected during right heart catheterization from 88 HFpEF patients without PH (control, n=40), HFpEF with isolated postcapillary PH (pc-PH, n=30), and HFpEF with combined post- and precapillary PH (cpc-PH, n=18). PGF2 alpha and 20-OH PGF2 alpha both pro- and anti-inflammatory molecules, were more significant predictors of HFpEF with cpc- PH compared to pc-PH (p=0.006). keywords: hfpef cache: translation-639.pdf plain text: translation-639.txt item: #67 of 204 id: translation-640 author: Breidenbach, Joshua title: Aerosolized Harmful Algal Bloom Toxin Microcystin-LR Induces Inflammatory Signaling in Human Airway Epithelial Cells date: 2023-05-03 words: 442 flesch: 34 summary: May 05; 11(1):e1-e2 Aerosolized Harmful Algal Bloom Toxin Microcystin-LR Induces Inflammatory Signaling in Human Airway Epithelial Cells Joshua D. Breidenbach, MS1*, Benjamin W. French1, Tamiya T. Gordon1, Andrew L. Kleinhenz1, Apurva Lad, MS1, Robin C. Su, PhD1, James C. Willey, MD2, Jeffrey R. Hammersley, MD2, R. Mark Wooten, PhD3, Erin L. Crawford, MS1, Nikolai N. Modyanov, PhD4, Deepak Malhotra, MD, PhD5, Justin G. Teeguarden, PhD1, Steven T. Haller, PhD1, David J. Kennedy, PhD1 1Division of Cardiology, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Division of Pulmonology and Critical Care Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 3Division of Infectious Diseases, Department of Medicine, The University of Toledo, Toledo, OH 43614 4Department of Physiology and Pharmacology, The University of Toledo, Toledo, OH 43614 5Division of Nephrology, Department of Medicine, The University of Toledo, Toledo, OH 43614 These blooms are often composed of outgrowths of cyanobacteria capable of producing the heptapeptide Microcystin-LR (MC- LR) which is a well-known hepatotoxin. keywords: medicine; toledo; university cache: translation-640.pdf plain text: translation-640.txt item: #68 of 204 id: translation-641 author: French, Benjamin title: Harmful Algal Bloom Impacts on Human Health: An Analysis of National Emergency Department Data in the U.S. from 2016 to 2018 date: 2023-05-03 words: 345 flesch: 36 summary: We sought to determine trends and patterns in diagnostic codes relating to HAB exposures from the Healthcare Cost and Utilization Project's (HCUP) Nationwide Emergency Department Sample (NEDS). Methods: We analyzed HCUP NEDS data from years 2016 to 2018 as these represented the years in which complete data was available using the World Health Organization (WHO) International Classification of Diseases-10 diagnosis codes for HAB exposure. keywords: hab; toledo cache: translation-641.pdf plain text: translation-641.txt item: #69 of 204 id: translation-642 author: Marellapudi, Amulya title: Cardioprotective Effects of Paraoxanase 3 in a Dahl Salt-Sensitive Rat Model of Chronic Kidney Disease date: 2023-05-03 words: 354 flesch: 43 summary: In female rats, by 8 weeks 100% mortality was observed in SS-Pon3 KO rats on high salt diet while no mortality was observed in SS rats on high salt. By 8 weeks, mortality was observed in 18.2% of male SS-Pon3 KO rats on high salt; no mortality was observed in male SS male rats on high salt. keywords: rats; salt cache: translation-642.pdf plain text: translation-642.txt item: #70 of 204 id: translation-643 author: Patel, Shivani C title: Harmful Algal Bloom Toxin Microcystin-LR Induces Macrophage Inflammation of Lung Tissues date: 2023-05-03 words: 429 flesch: 32 summary: Results: Gene expression profiles of mice exposed to HAB toxin aerosols demonstrated a significant increase in the CD68 gene expressed by macrophages in C57BL/6J mice. The University of Toledo Translation Journal of Medical Sciences Cardiology Abstract, Department of Medicine Research Symposium UTJMS 2023 keywords: toledo; university cache: translation-643.pdf plain text: translation-643.txt item: #71 of 204 id: translation-644 author: Ranabothu, Meghana title: Paraoxanase-1 Modulates Cardiotonic Steroid Induced Cardiac Inflammation and Fibrosis in Dahl Salt Sensitive Model of Chronic Kidney Disease date: 2023-05-03 words: 360 flesch: 34 summary: Methods: Dahl salt-sensitive wild type, PON1 knockout, and PON1 knockout rats that were treated with 3E9 anti-CTS monoclonal antibody were fed a high salt diet for five weeks to induce hypertensive renal disease and elevate CTS levels. *Corresponding author: Meghana.Ranabothu@rockets.utoledo.edu Published: 05 May 2023 Objective: Cardiotonic steroids (CTS) are known ligands of the Na+/K+-ATPase (NKA) and chronic elevations in volume expanded conditions such as hypertension and chronic kidney disease (CKD). keywords: cts; disease cache: translation-644.pdf plain text: translation-644.txt item: #72 of 204 id: translation-645 author: Soehnlen, Sophia title: Paraoxanase 1 Deletion Leads to Increased Cardiac Remodeling and Cardiac Fibrosis in a Dahl Salt-Sensitive Rat Model of Chronic Kidney Disease date: 2023-05-03 words: 385 flesch: 34 summary: Results: SS-Pon1 KO male rats demonstrated a significantly increased relative cardiac wall thickness (0.77+/-0.05 vs. 0.58+/-0.02) and fractional shortening (0.62+/-0.02 vs. 0.53+/-0.01), as well as significantly increased mean velocity of circumferential fiber shortening (circ/s, 6.37+/-0.33 vs. 5.52+/- 0.17) and cardiac index (ml/min/kg, 184+/-18 vs. 136+/-11) vs age matched SS rats. Upon histological examination, heart sections of SS-Pon1 KO male rats showed a significant increase in fibrosis and heart-weight-to-body-weight ratio compared to the age matched SS rats. keywords: https://dx.doi.org/10.46570/utjms.vol11-2023-645 cache: translation-645.pdf plain text: translation-645.txt item: #73 of 204 id: translation-646 author: Sood, Ambika title: Paraoxanase 1 Regulation of Cardiac Inflammation and Fibrosis in a Dahl Salt-Sensitive Rat Model of Chronic Kidney Disease date: 2023-05-03 words: 388 flesch: 28 summary: Results: RT PCR analysis of cardiac left ventricular tissue revealed an increase in the expression of natriuretic peptide A (p< 0.0001) and myosin heavy chain 7 (p< 0.0001), suggesting cardiac hypertrophy in SS-PON-1 KO male rats compared to controls (SS). Results are consistent with the echocardiography analysis and trichrome analysis indicating increased cardiac fibrosis in SS-PON-1 KO vs SS rats. keywords: https://dx.doi.org/10.46570/utjms.vol11-2023-646 cache: translation-646.pdf plain text: translation-646.txt item: #74 of 204 id: translation-647 author: Waack, Andrew title: Venous Stent Migration to the Heart: Case Report and Review of the Literature date: 2023-05-03 words: 337 flesch: 43 summary: We present a case of bilateral iliac vein stent migrations into the right ventricle and interlobar artery. Bilateral iliac vein stents were placed five years prior and a pacemaker six weeks prior. keywords: medicine; toledo cache: translation-647.pdf plain text: translation-647.txt item: #75 of 204 id: translation-648 author: Yassine, Shereen G. title: Exposure to Nanoplastics Induces an Inflammatory Response in Healthy and Type 2 Diabetic Primary Human Proximal Tubular Epithelial Cells date: 2023-05-03 words: 302 flesch: 30 summary: Conclusion: Our results suggest that NPs induce an inflammatory response in human PTECs, which may be enhanced in prevalent, pre-existing conditions, such as T2D, with important implications for human health that warrant further investigation. Methods: Healthy and T2D primary human PTECs were cultured in 96 well-plates and exposed to 0.026%, 0.052% w/v 0.05 µm monodisperse polystyrene microspheres (or vehicle) for 24 hours. keywords: toledo; university cache: translation-648.pdf plain text: translation-648.txt item: #76 of 204 id: translation-649 author: Chinnam, Sahithi title: Hypercalcemia in the Inpatient Setting: : A Case Report date: 2023-05-03 words: 314 flesch: 54 summary: A 57-year-old female with a history of bipolar disease, depression, diabetes, and hypothyroidism presents with worsening mental status changes, visual hallucinations, and depressive symptoms. Deterioration can occur in both physical and mental functions of hypercalcemic patients acutely. keywords: toledo cache: translation-649.pdf plain text: translation-649.txt item: #77 of 204 id: translation-650 author: Prevoznik, Stephen title: Glucocorticoid-induced Stress Mechanism in Mouse Primary Neurons date: 2023-05-03 words: 341 flesch: 56 summary: One plate of cortex neurons was grown in an IncuCyte incubator to allow axon length to be continuously measured by NueroTrack software. This study aimed to examine whether inducing a depression-like state caused any changes in gene expression or axon length in cultured neurons. keywords: toledo cache: translation-650.pdf plain text: translation-650.txt item: #78 of 204 id: translation-651 author: Richard, Brennon title: Double Negative T Cell Proportion of CD3+ Cells Present in the Thyroid Microenvironment is an Immunogenomic Marker for Predicting Thyroid Cancer date: 2023-05-03 words: 458 flesch: 37 summary: Furthermore, our group is working on amplifying DN T cell markers on a PCR-based platform to allow a more economically viable diagnostic test. Using High-throughput gene expression analysis, we will analyze the mRNA expression of DN T cells present in the microenvironment. keywords: toledo; university cache: translation-651.pdf plain text: translation-651.txt item: #79 of 204 id: translation-653 author: Aziz, Muhammad title: Does I-Scan Improve Adenoma Detection Rate Compared to High-Definition Colonoscopy? : A Systematic Review and Meta-Analysis date: 2023-05-03 words: 332 flesch: 45 summary: Full-text RCTs and cohort studies directly comparing i-scan and HD colonoscopy were deemed eligible for inclusion. Future studies evaluating other outcomes of interest such as proximal adenomas and serrated lesions are warranted. keywords: colonoscopy; scan cache: translation-653.pdf plain text: translation-653.txt item: #80 of 204 id: translation-654 author: Aziz, Muhammad title: Impact of Guidewire Caliber on ERCP Outcomes: Systematic Review and Meta-Analysis Comparing 0.025- and 0.035-Inch Guidewires date: 2023-05-03 words: 347 flesch: 48 summary: The impact of guidewire caliber on endoscopic retrograde pancreatography (ERCP) outcomes are not clear. Other outcomes (overall cannulation rate, cholangitis, perforation, bleeding, use of adjunct techniques) were also comparable. keywords: toledo; university cache: translation-654.pdf plain text: translation-654.txt item: #81 of 204 id: translation-655 author: Lad, Apurva title: Cyanotoxin Degrading Lake Bacteria Significantly Alleviate Microcystin-LR Induced Hepatotoxicity in Both In Vitro and In Vivo Models date: 2023-05-03 words: 395 flesch: 29 summary: Mass spectrometric analysis of urine from mice pre-treated with the bacteria prior to MC-LR exposure, revealed significant reduction in urine MC-LR levels and elevated levels of the detoxified metabolite - MC-LR Cysteine as compared to the untreated control group. https://dx.doi.org/10.46570/utjms.vol11-2023-655 https://dx.doi.org/10.46570/utjms.vol11-2023-655 mailto:Apurva.Lad@rockets.utoledo.edu https://dx.doi.org/10.46570/utjms.vol11-2023-655 UTJMS 11(1):e1-e2 https://dx.doi.org/10.46570/utjms.vol11-2023-655 2 ©2023 UTJMS Conclusion: These results suggest a potential novel therapeutic approach that can be developed for MC- LR induced toxicity. keywords: toledo cache: translation-655.pdf plain text: translation-655.txt item: #82 of 204 id: translation-656 author: Aziz, Muhammad title: Lactated Ringer's Vs Normal Saline for Acute Pancreatitis: : An Updated Systematic Review and Meta-Analysis date: 2023-05-03 words: 402 flesch: 38 summary: The overall ICU admission was lower in LR group compared to NS group (RR: 0.43, CI: 0.22-0.84). Subgroup analysis of RCTs demonstrated lower length of hospital stay for LR group compared to NS group (MD: 0.77 days, CI: 1.44 -0.09 days). keywords: toledo; university cache: translation-656.pdf plain text: translation-656.txt item: #83 of 204 id: translation-657 author: Battepati, Dhanushya title: Severe Transaminitis in Allopurinol-Induced DILI presenting as DRESS Syndrome date: 2023-05-03 words: 342 flesch: 41 summary: The patient we present demonstrates a hepatocellular pattern of liver injury. Liver injury pattern in drug reaction with eosinophilia and systemic symptoms (DRESS) is either cholestatic or hepatocellular. keywords: patient; toledo cache: translation-657.pdf plain text: translation-657.txt item: #84 of 204 id: translation-658 author: Devanaboyina, Monika title: Analysis of Demographic and Staging Characteristics in Patients with Colorectal Cancer Using the SEER Registry date: 2023-05-03 words: 343 flesch: 53 summary: The incidence of CRC increased with age where ages 75+ had the highest incidence at 211.8 per 100,000, compared to 70.7 for ages 50-64. Of note, Asian females aged 50-64, Hispanic females ages 65 and older, and Black and White females ages 75+ were equally likely to present with local or regional disease. keywords: ages cache: translation-658.pdf plain text: translation-658.txt item: #85 of 204 id: translation-659 author: Dhoop, Sudheer title: Metastatic Renal Cell Carcinoma to the Descending Colon Presenting as Recurrent Hematochezia date: 2023-05-03 words: 234 flesch: 32 summary: Our case demonstrates that interval metastasis should always be on the differential for persistent GI bleeding in the setting of RCC and it highlights challenges in management of hematochezia related to colorectal metastasis of RCC. This report documents a case of an individual with solitary metastasis of RCC to the descending colon presenting with recurrent hematochezia. keywords: toledo cache: translation-659.pdf plain text: translation-659.txt item: #86 of 204 id: translation-663 author: Farrow, David title: Iron Deficiency Anemia Secondary to Colonic Diaphragm Disease date: 2023-05-03 words: 474 flesch: 38 summary: One uncommon complication of chronic NSAID use is the formation of diaphragm-like strictures, characterized by the circumferential narrowing of mucosal membranes. NSAID-induced colopathy was suspected to be the cause of anemia, for which she was counseled to discontinue NSAID use. keywords: diaphragm; toledo cache: translation-663.pdf plain text: translation-663.txt item: #87 of 204 id: translation-664 author: Farrow, David title: Rectal Ischemia Status Post EVAR and COVID-19 date: 2023-05-03 words: 331 flesch: 38 summary: It is hypothesized that a hypercoagulable state caused by COVID-19 infection coupled with ongoing hypotension in the setting of critical illness in our patient with significant peripheral arterial disease led to the low flow state in bilateral iliac arteries causing ischemic proctitis. During his admission, he was found to have acute left lower extremity ischemia requiring stenting of his superficial femoral artery and abdominal endovascular aneurysm repair (EVAR). keywords: toledo; university cache: translation-664.pdf plain text: translation-664.txt item: #88 of 204 id: translation-665 author: Farrow, David title: Use of Endoscopic Vacuum Therapy to Repair Colonic Anastomotic Leaks: : A Meta Analysis date: 2023-05-03 words: 348 flesch: 47 summary: Endoscopic vacuum therapy (EVT) has recently emerged as a treatment modality for patients who experience anastomotic leak after surgery with an incidence of 6-30%. Treatment of anastomotic leaks using EVT in the upper gastrointestinal tract has been well documented. keywords: toledo cache: translation-665.pdf plain text: translation-665.txt item: #89 of 204 id: translation-666 author: Farrow, David title: ERCP in Patient with Situs Inversus Totalis date: 2023-05-03 words: 317 flesch: 36 summary: Case Description/Methods: An 89-year-old male presented with a history of epigastric abdominal pain for one month associated with nausea and non-bloody, non-bilious vomiting. This case details a patient found to have situs inversus totalis (SIT) while being evaluated for abdominal pain and ultimately requiring ERCP for choledocholithiasis. keywords: inversus cache: translation-666.pdf plain text: translation-666.txt item: #90 of 204 id: translation-667 author: Ghazaleh, Sami title: Do Topical Corticosteroids Induce Histologic Remission and Improve Clinical Symptoms in Eosinophilic Esophagitis? - : A Systematic Review and Meta-Analysis date: 2023-05-03 words: 318 flesch: 29 summary: Conclusion: Our meta-analysis demonstrated that topical corticosteroids were more effective than placebo in achieving histologic remission and improving clinical symptoms. Methods: We conducted a systematic review and meta-analysis of studies that investigated the efficacy and safety of topical corticosteroids compared with placebo in eosinophilic esophagitis. keywords: esophageal cache: translation-667.pdf plain text: translation-667.txt item: #91 of 204 id: translation-669 author: Akpunonu, Basil title: Bilateral Accessory (Aberrant) Renal Arteries Associated With Uncontrolled Hypertension—Role of Renin-Angiotensin-Aldosterone Antagonist Drugs for Treatment Goal: : A Case Report date: 2023-05-03 words: 324 flesch: 24 summary: Conclusion: Accessory renal arteries could lead to perfusion abnormalities, contribute to or exacerbate maintenance and control of blood pressure. A computed tomographic angiography (CTA) and magnetic resonance angiography (MRA) showed accessory renal arteries in both the right and left kidneys. keywords: arteries; toledo cache: translation-669.pdf plain text: translation-669.txt item: #92 of 204 id: translation-670 author: Ghazaleh, Sami title: Use of Smartphone Applications to Augment Colonoscopy Preparation Instructions and Effect on Quality of Colonoscopy Preparation and Adenoma Detection Rate – : A Systematic Review and Meta-Analysis date: 2023-05-03 words: 338 flesch: 40 summary: Conclusion: Our meta-analysis demonstrated that the use of smartphone applications to augment colonoscopy preparation instructions improves the quality of colonoscopy preparation and adenoma detection rate. Eight studies reported adequate bowel preparation, which was significantly higher in patients who used smartphone applications compared with controls (RR 1.17, 95% CI 1.06 – 1.30, p < 0.003, I2 = 90%). keywords: preparation cache: translation-670.pdf plain text: translation-670.txt item: #93 of 204 id: translation-671 author: Akpunonu, Basil title: A Case of Rhabdomyolysis with Rigors date: 2023-05-03 words: 325 flesch: 30 summary: *Corresponding author: Basil.Akpunonu@utoledo.edu Published: 05 May 2023 Introduction: Rhabdomyolysis is a potential life- threatening condition caused by extensive skeletal muscle breakdown with leakage of toxic muscle contents into the circulation. The pathophysiologic hallmark of rhabdomyolysis regardless of etiology is increased free ionized calcium due to cellular energy depletion (ATP) or direct plasma membrane rupture and consequent intensified muscle contractility, mitochondrial dysfunction, and production of oxygen radicals. keywords: medicine; rhabdomyolysis cache: translation-671.pdf plain text: translation-671.txt item: #94 of 204 id: translation-672 author: Halloran, Sean title: Discovery of Gastric Adenocarcinoma during PEG Tube Placement in Patient with Epiglottic Squamous Cell Carcinoma date: 2023-05-03 words: 331 flesch: 40 summary: Case Description: A 77-year old male presented for upper endoscopy with PEG tube placement. He was referred for PEG tube placement for nutrition supplementation due to 5 months of progressive dysphagia, malnutrition, and unintentional weight loss. keywords: peg; tube cache: translation-672.pdf plain text: translation-672.txt item: #95 of 204 id: translation-673 author: Halloran, Sean J title: Hepatic Sarcoidosis Presenting as Cholestatic Liver Injury Exacerbated by Nitrofurantoin Use date: 2023-05-03 words: 329 flesch: 34 summary: We report a patient with hepatic sarcoidosis presenting as cholestatic liver injury exacerbated by nitrofurantoin use. This patient’s presentation was deemed most consistent with hepatic sarcoidosis. keywords: sarcoidosis cache: translation-673.pdf plain text: translation-673.txt item: #96 of 204 id: translation-674 author: Jay, Bryanna title: Primary Gastric Squamous Cell Carcinoma with Concurrent H. Pylori Infection and Colonic Metastasis date: 2023-05-03 words: 326 flesch: 45 summary: H. pylori infection is a known risk factor for gastric malignancies but, only one case has been reported with an association between the two. Primary gastric squamous cell carcinoma (PGSCC) is a rare, aggressive, malignancy that requires EGD with biopsy and pathology for diagnosis. keywords: gastric cache: translation-674.pdf plain text: translation-674.txt item: #97 of 204 id: translation-675 author: Aziz, Muhammad title: Safety and Effectiveness of Endoluminal Vacuum-Assisted Closure for Esophageal Defects: : Systematic Review and Meta-Analysis date: 2023-05-03 words: 368 flesch: 48 summary: We performed a systematic review and pooled analysis of available literature to assess the safety and effectiveness of EVAC for esophageal defects. Methods: We queried PubMed/Medline, Embase, Cochrane, and Web of Science through September 25, 2020 to include all pertinent articles highlighting the safety and effectiveness profile of EVAC for esophageal defects. keywords: toledo; university cache: translation-675.pdf plain text: translation-675.txt item: #98 of 204 id: translation-676 author: O’Shea, Daniel title: Gastrointestinal Ulceration as a Manifestation of Severe Dermatomyositis -: A Case Report date: 2023-05-03 words: 317 flesch: 38 summary: May 05; 11(1):e1-e1 Gastrointestinal Ulceration as a Manifestation of Severe Dermatomyositis - A Case Report Daniel O’Shea1*, Dhanushya Battepati1, Brandon Speedy1, David Farrow MD1, Megan Karrick DO1, Anas Renno MD1, Benjamin Hart MD1 1Division of Gastroenterology and Hepatology, Department of Medicine, The University of Toledo, Toledo, OH 43614 Three months later, a diagnosis of acute fulminant dermatomyositis was made with NXP-2, GAD-65 positivity on biopsy. keywords: dermatomyositis; toledo cache: translation-676.pdf plain text: translation-676.txt item: #99 of 204 id: translation-677 author: Akpunonu, Basil title: Anaplastic Large Cell Lymphoma Presenting as Ulcerative Facial Mass: : A Case Report date: 2023-05-03 words: 345 flesch: 32 summary: Anaplastic large cell lymphoma (ALCL) is a rare form of non-Hodgkin lymphoma (NHL) that can be aggressive with rapid speed, thus mandating a timely diagnosis to optimize treatment and deter progression. The cutaneous involvement may resemble common dermatologic conditions, delaying diagnosis. keywords: toledo cache: translation-677.pdf plain text: translation-677.txt item: #100 of 204 id: translation-678 author: Sayeh, Wasef title: EUS Guided Through the Needle Biopsy Versus Fine Needle Aspiration for Pancreatic Cystic Lesions: : A Systemic Review and Meta-analysis date: 2023-05-03 words: 393 flesch: 47 summary: Recent studies have investigated the EUS guided through the needle biopsy (EUS-TTNB) as an alternative method. EUS-TTNB should be considered https://dx.doi.org/10.46570/utjms.vol11-2023-678 https://dx.doi.org/10.46570/utjms.vol11-2023-678 mailto:wasef.sayeh@utoledo.edu https://dx.doi.org/10.46570/utjms.vol11-2023-678 UTJMS 11(1):e1-e2 https://dx.doi.org/10.46570/utjms.vol11-2023-678 2 ©2023 UTJMS where applicable clinically for improving the diagnostic yield in patients undergoing evaluation of PCLs. keywords: eus; md1 cache: translation-678.pdf plain text: translation-678.txt item: #101 of 204 id: translation-679 author: Waack, Andrew title: Epididymo-orchitis Secondary to Colovesical Fistula date: 2023-05-03 words: 313 flesch: 45 summary: May 5; 11(1):e1-e1 Epididymo-orchitis Secondary to Colovesical Fistula Andrew Waack1*, Meghana Ranabothu, M21, Neha J Patel, MD1 1Division of Internal Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 *Corresponding author: Andrew.waack@rockets.utoledo.edu Published: 05 May 2023 Introduction: Acute epididymo-orchitis is a common cause of scrotal pain in adults. We present a unique case of epididymo-orchitis secondary to colovesical fistula caused by chronic diverticulitis. keywords: epididymo; orchitis cache: translation-679.pdf plain text: translation-679.txt item: #102 of 204 id: translation-680 author: Sayeh, Wasef title: EUS Guided Gastroenterostomy Vs Surgical Gastrojejunostomy for the Palliation of Malignant Gastric Outlet Obstruction: : A Systemic Review and Meta-analysis date: 2023-05-03 words: 387 flesch: 43 summary: However, very few studies were done on less aggressive procedures including EUS guided gastroenterostomy (EUS-GE). A Systemic Review and Meta- analysis Wasef Sayeh1*, Azizullah Beran, MD1, Sami Ghazaleh, MD1, Amna Iqbal, MD1, Justin Chuang, Mohammad Safi, MD1, Saif-Eddin Malhas, MD1, Ziad Abuhelwa, MD1, Waleed Kokher, MD1, Omar Sajdeya, MD1, Muhammad Aziz, MD2, Ajit Ramadugu, MD2, Ali Nawras, MD2 1Division of Internal Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Division of Gastroenterology and Hepatology, Department of Medicine, The University of Toledo, Toledo, OH 43614 *Corresponding author: wasef.sayeh@utoledo.edu Published: 05 May 2023 Background: Gastric Outlet Obstruction (GOO) was traditionally treated palliatively with surgical gastrojejunostomy (SGJ). keywords: md1; toledo cache: translation-680.pdf plain text: translation-680.txt item: #103 of 204 id: translation-681 author: Sayeh, Wasef title: Early Feeding Versus Delayed Feeding after Therapeutic Endoscopic Intervention in Upper GI Bleeding: : A Systematic Review and Meta-analysis date: 2023-05-03 words: 389 flesch: 44 summary: The secondary outcomes were the occurrence of early bleeding, late bleeding and the length of hospital stay. Our meta-analysis demonstrated that early feeding after endoscopic interventions in patients with upper GI bleeding appears to be relatively safe. keywords: bleeding; md1 cache: translation-681.pdf plain text: translation-681.txt item: #104 of 204 id: translation-682 author: Ranabothu, Meghana title: Rare Occurrence of Primary Gastric Lymphoma: : A Case Report date: 2023-05-03 words: 268 flesch: 40 summary: Conclusion: Primary gastric lymphoma is a rare cause of gastric mass. Primary gastric lymphoma (PGL), a rare gastrointestinal cancer, arises from lymphocytes found in the lamina propria of the stomach because of chronic inflammation. keywords: lymphoma cache: translation-682.pdf plain text: translation-682.txt item: #105 of 204 id: translation-683 author: Renno, Anas title: Recurrent Pancreatitis Secondary to Common Channel Volvulus through Petersen’s Space Defect in a Patient with Roux-En-Y Bypass date: 2023-05-03 words: 463 flesch: 39 summary: We present a case of recurrent pancreatitis in a patient with Roux-En-Y bypass found to have common channel hernia through a Petersen’s space defect. This case demonstrates recurrent pancreatitis in a patient with a history of Roux-En-Y bypass found to have a common channel volvulus through a Petersen’s space defect. keywords: pancreatitis; patient cache: translation-683.pdf plain text: translation-683.txt item: #106 of 204 id: translation-684 author: Renno, Anas title: Comparative Efficacy of Treatment Options for Prevention of Post-TIPS Hepatic Encephalopathy: : A Systematic Review and Network Meta-analysis date: 2023-05-03 words: 432 flesch: 27 summary: May 5; 11(1):e1-e2 Comparative Efficacy of Treatment Options for Prevention of Post-TIPS Hepatic Encephalopathy: A Systematic Review and Network Meta-analysis Anas Renno1*, Zohaib Ahmed, MD1, Syeda Faiza Arif, MD1, Muhammad Aziz, MD1, Umair Iqbal, MD, Ahmad Nawaz, MD1 Wade Lee-Smith, MLIS2, Joyce Badal, MD1, Toseef Javaid, MD1, Ali Nawras, MD1, Mona Hassan, MD1, Sammy Saab, MD1 1Division of Gastroetnerology and Hepatology, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Department of University Libraries, The University of Toledo, Toledo, OH 43614 Therefore, we conducted a network meta-analysis to investigate the efficacy of multiple pharmacological regimens in preventing post-TIPS HE. Methods: A comprehensive search strategy to identify reports of studies of rifaximin use and post-TIPS hepatic encephalopathy was developed in Embase (Embase.com, Elsevier) by an experienced health sciences librarian [WL-S], using truncated keywords, phrases, and subject headings. keywords: md1; tips cache: translation-684.pdf plain text: translation-684.txt item: #107 of 204 id: translation-685 author: Renno, Anas title: Efficacy and Safety of Cap Assisted vs. Conventional Endoscopic Esophageal Foreign Body Removal - : Systematic Review and Meta-analysis date: 2023-05-03 words: 384 flesch: 41 summary: May 5; 11(1):e1-e2 Efficacy and Safety of Cap Assisted vs. Conventional Endoscopic Esophageal Foreign Body Removal- Systematic Review and Meta-analysis Anas Renno1*, Zohaib Ahmed MD1, Syeda Faiza Arif MD1, Stephanie Lin Ong MD1, Joyce Badal MD1, Wade lee-Smith MLS2, Umer Farooq MD1, Muhammad Aziz MD1, Yaseen Alastal MD1, Ali Nawras MD1 1Division of Gastroenterology and Hepatology, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Department of University Libraries, The University of Toledo, Toledo, OH 43614 https://dx.doi.org/10.46570/utjms.vol11-2023-685 https://dx.doi.org/10.46570/utjms.vol11-2023-685 mailto:anas.renno@utoledo.edu https://dx.doi.org/10.46570/utjms.vol11-2023-685 UTJMS 11(1):e1-e2 https://dx.doi.org/10.46570/utjms.vol11-2023-685 2 ©2023 UTJMS Conclusion: This systematic review and meta-analysis showed that the cap-assisted technique has higher efficacy and better safety than conventional techniques. keywords: md1; toledo cache: translation-685.pdf plain text: translation-685.txt item: #108 of 204 id: translation-686 author: Akpunonu, Basil title: Lung Cancer Metastasis to the Pituitary Gland date: 2023-05-03 words: 323 flesch: 44 summary: Here, we present a case of pituitary gland metastasis from underlying lung cancer in a patient presenting with a predominance of pituitary symptoms. Worsening pituitary symptoms with an enlarging pituitary mass and widespread metastases should alert consideration for pituitary metastasis and a search for a primary cancer site. keywords: cancer; pituitary cache: translation-686.pdf plain text: translation-686.txt item: #109 of 204 id: translation-687 author: Doddi, Sishir title: Prevalence and Clinical Significance of Antiphospholipid Antibodies in Hospitalized Patients with COVID-19 Infection date: 2023-05-03 words: 378 flesch: 27 summary: Previous literature suggests that the presence of antiphospholipid antibodies (APA) is an important factor for thrombosis in COVID-19 patients. This single-institution retrospective study aims to find if the prevalence of APA in COVID-19 patients has any clinical significance. keywords: medicine; toledo cache: translation-687.pdf plain text: translation-687.txt item: #110 of 204 id: translation-688 author: Alharbi, Abdulmajeed title: Bictegravir, Emtricitabine & Tenofovir Alafenamide-associated Acute Pancreatitis date: 2023-05-03 words: 332 flesch: 33 summary: Healthcare providers should be aware of the unusual adverse event of Bictegravir, Emtricitabine, and Tenofovir alafenamide (Biktarvy) as a potential cause of pancreatitis in patients with Human Immunodeficiency Virus (HIV). Abdulaziz Aldhafeeri MD1, Nezam Altorok MD2 1Division of Internal Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Division of Rheumatology, Department of Medicine, The University of Toledo, Toledo, OH 43614 *Corresponding author: Abdulmajeed.Alharbi@utoledo.edu Published: 05 May 2023 Background: Bictegravir, Emtricitabine & Tenofovir alafenamide (Biktarvy) is now considered as the first line treatment for Human Immunodeficiency virus (HIV). keywords: toledo cache: translation-688.pdf plain text: translation-688.txt item: #111 of 204 id: translation-689 author: Alharbi, Abdulmajeed title: Vocal Cord Palsy and Neutropenia: : Unusual Presentation of B-12 Deficiency in Adult Patient, A Case Report date: 2023-05-03 words: 327 flesch: 42 summary: This case highlights the fact that manifestations of vitamin B12 deficiency can be highly variable and underscores the need to keep this disorder on the differential diagnosis in a variety of clinical presentations. *Corresponding author: Abdulmajeed.Alharbi@utoledo.edu Published: 05 May 2023 Background: Vitamin B12 deficiency commonly causes megaloblastic anemia and rarely pancytopenia. keywords: patient cache: translation-689.pdf plain text: translation-689.txt item: #112 of 204 id: translation-690 author: Ali, Aizaz title: Renal Cell Carcinoma Metastasis to the Left Atrium date: 2023-05-03 words: 350 flesch: 37 summary: Given that there is no established algorithm for managing cardiac metastases from RCC, a surgical approach seems most feasible. In addition, affected patients are mostly asymptomatic and can present variably. keywords: patient cache: translation-690.pdf plain text: translation-690.txt item: #113 of 204 id: translation-691 author: Alqadi, Mohammad title: Effect of Antiplatelet Medications on Critically Ill Patients with Pre-existing Atrial Fibrillation date: 2023-05-03 words: 339 flesch: 31 summary: *Corresponding author: Mohammad.Alqadi@utoledo.edu Published: 05 May 2023 Introduction: Limited data was found about the usage of antiplatelet medications on patients who previously diagnosed with atrial fibrillation (AF), and were critically ill and admitted to stepdown care unit (SDU) due to other acute conditions. Our goal to clarify the effect of antiplatelet medications on the adverse events (i.e., transfer to intensive care unit (ICU) or death), and the influence of the associated clinical factors. keywords: toledo cache: translation-691.pdf plain text: translation-691.txt item: #114 of 204 id: translation-692 author: Badal, Joyce title: Lithium-Induced Nephrogenic Diabetes Insipidus Self-Treated With Beer Potomania and Masquerading as Shock: : A Case Report date: 2023-05-03 words: 357 flesch: 35 summary: Nephrogenic diabetes insipidus (NDI) is a known adverse effect from lithium use, commonly presenting as polyuria and polydipsia. We stopped lithium and initiated hypotonic fluids, amiloride, hydrochlorothiazide, and indomethacin. keywords: toledo; university cache: translation-692.pdf plain text: translation-692.txt item: #115 of 204 id: translation-693 author: Campbell, Drew title: Exploring the Accuracy of the Medication Reconciliation Process on the Medical Floor date: 2023-05-03 words: 311 flesch: 35 summary: Of the charts where medication errors were found, 71.3% had three or more discrepancies. Our next focus should be on understanding why medication lists contain erroneous information because of added or missing medications. keywords: medication cache: translation-693.pdf plain text: translation-693.txt item: #116 of 204 id: translation-694 author: Chinnam, Sahithi title: The Importance of Neuro-Imaging in Patients with Symptomatic Presentation of Both Cortical and Subcortical Dementia date: 2023-05-03 words: 305 flesch: 42 summary: The University of Toledo Translation Journal of Medical Sciences Internal Medicine Abstract, Department of Medicine Research Symposium UTJMS 2023 May 5; 11(1):e1-e1 The Importance of Neuro-Imaging in Patients with Symptomatic Presentation of Both Cortical and Subcortical Dementia S Chinnam, DO1*, P Patel, DO1, J Creech, DO1 1Division of Internal Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 keywords: medicine; toledo cache: translation-694.pdf plain text: translation-694.txt item: #117 of 204 id: translation-695 author: Holtzapple, Zachary title: Are Three Better than Two? – : Incidental Finding of Incomplete Cor Triatrium Dextrum during 2nd Trimester of Pregnancy date: 2023-05-03 words: 243 flesch: 32 summary: *Corresponding author: Zachary.Holtzapple@utoledo.edu Published: 05 May 2023 Background: Cor triatriatum sinistrum is a type of congenital heart defect that occurs due to the left atrium being divided into two chambers by a fibromuscular septum. An even rarer subsection of this is cor triatriatum dextrum, in which the fibromuscular septum divides the right atrium. keywords: cor cache: translation-695.pdf plain text: translation-695.txt item: #118 of 204 id: translation-696 author: Holtzapple, Zachary title: Who Left the Dog Out (of the History)? - : Capnocytophage Canimorus Baceteremia Induced Sepsis date: 2023-05-03 words: 189 flesch: 41 summary: - Capnocytophage Canimorus Baceteremia Induced Sepsis Zachary Holtzapple MD1*, Wilfred J. G. Ellis MD1 1Division of Internal Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 *Corresponding author: Zachary.Holtzapple@utoledo.edu Published: 05 May 2023 Capnocytophage canimorsus is a gram-negative rod bacterium that composes the microbial biome in the oral cavity of some canines and felines. The University of Toledo Translation Journal of Medical Sciences Internal Medicine Abstract, Department of Medicine Research Symposium UTJMS 2023 keywords: medicine cache: translation-696.pdf plain text: translation-696.txt item: #119 of 204 id: translation-697 author: Hunyadi, Jonathan title: Antioxidant Therapy Restores Hepatic Metabolic Enzymes Altered by Exposure to Microcystin-LR in a Murine Model of Non-Alcoholic Fatty Liver Disease date: 2023-05-03 words: 410 flesch: 20 summary: May 5; 11(1):e1-e2 Antioxidant Therapy Restores Hepatic Metabolic Enzymes Altered by Exposure to Microcystin-LR in a Murine Model of Non-Alcoholic Fatty Liver Disease Jonathan Hunyadi, BS1*, Apurva Lad, PhD1, Joshua D. Breidenbach, MS1, Jacob Connolly, UG1, Fatimah K. Khalaf, MBchB, PhD1, Prabhatchandra Dube, PhD1, Shungang Zhang, PhD1, Andrew L. Kleinhenz, BS1, David Baliu-Rodriguez, PhD1, Dragan Isailovic, PhD1, Terry Hinds, PhD, Deepak Malhotra MD, PhD2, Steven T. Haller PhD1, David J. Kennedy PhD1 1Division of Cardiovascular Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Division of Nephrology, Department of Medicine, The University of Toledo, Toledo, OH 43614 8-OHDG levels in urine and protein carbonylation in liver, both markers of oxidative stress, were significantly downregulated upon antioxidant treatment after MC-LR exposure. keywords: phd1; toledo cache: translation-697.pdf plain text: translation-697.txt item: #120 of 204 id: translation-698 author: Iqbal, Amna title: Hepatitis C Screening in Pregnancy: : A Single Center Quality Improvement Experience date: 2023-05-03 words: 485 flesch: 35 summary: We conducted a quality improvement project in our hospital regarding Hepatitis C screening among pregnant women. Our objective was to assess compliance with CDC guideline recommendation regarding Hepatitis C screening in pregnant women and suggest ways to improve it. keywords: hepatitis cache: translation-698.pdf plain text: translation-698.txt item: #121 of 204 id: translation-699 author: Iqbal, Amna title: Mantle Cell Lymphoma With GI Involvement Presenting as Bilateral Eyelid Swelling date: 2023-05-03 words: 463 flesch: 46 summary: We describe a case of MCL presenting as bilateral eyelid swelling. Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin lymphoma accounting for about 5% of non-Hodgkin lymphomas. keywords: https://dx.doi.org/10.46570/utjms.vol11-2023-699; mcl cache: translation-699.pdf plain text: translation-699.txt item: #122 of 204 id: translation-700 author: Iqbal, Amna title: Nosocomial vs Healthcare Associated vs Community Acquired SBP – : A Systematic Review and Meta-Analysis date: 2023-05-03 words: 475 flesch: 42 summary: Number of N-SBP, HA-SBP and CA-SBP episodes, ascitic fluid culture results and previous SBP episode data was gathered. Spontaneous bacterial peritonitis (SBP) is a common complication in decompensated liver cirrhosis. keywords: sbp; toledo cache: translation-700.pdf plain text: translation-700.txt item: #123 of 204 id: translation-701 author: Khader, Yasmin title: Sarcoidosis and increased risk of Colorectal cancer: : A systematic review and Meta-analysis date: 2023-05-03 words: 345 flesch: 46 summary: From each study, we collected the number of sarcoidosis patients with and without colorectal cancer. The aim of this study is to evaluate the correlation between sarcoidosis and the risk of colorectal cancer. keywords: toledo cache: translation-701.pdf plain text: translation-701.txt item: #124 of 204 id: translation-702 author: Khader, Yasmin title: Do Patients with Scleroderma Benefit from Surgical Treatment for Gastroesophageal Reflux? date: 2023-05-03 words: 351 flesch: 49 summary: Anti-reflux medications are still considered the first line treatment of GERD in SSc patients. We conducted this meta-analysis to assess for the benefit of surgery in treating GERD in SSc patients. keywords: toledo cache: translation-702.pdf plain text: translation-702.txt item: #125 of 204 id: translation-703 author: Khader, Yasmin title: Predictors of Remission in Rheumatoid Arthritis Patients Treated with Biologics: : A Systematic Review and Meta-Analysis date: 2023-05-03 words: 357 flesch: 44 summary: We included all studies that used a multivariate model to assess for the predictors of remission in RA patients treated with biologics. May 5; 11(1):e1-e1 Predictors of Remission in Rheumatoid Arthritis Patients Treated with Biologics: A Systematic Review and Meta- Analysis Yasmin Khader, MD1*, A. Beran, MD1, S. Ghazaleh, MD2, S. Devis, MD1, N. Altorok, MD3 1Division of , Department of Medicine, The University of Toledo, Toledo, OH 43614 2Division of, Department of Medicine, The University of Toledo, Toledo, OH 43614 3Division of, Department of Medicine, The University of Toledo, Toledo, OH 43614 keywords: toledo cache: translation-703.pdf plain text: translation-703.txt item: #126 of 204 id: translation-704 author: Khokher, Waleed title: Clinically Significant Gastrointestinal Bleeding Using Proton Pump Inhibitors or Histamine Type-2 Receptor Antagonists in Patients Intubated for Over 48 Hours: : A Systematic Review and Meta-Analysis date: 2023-05-03 words: 374 flesch: 33 summary: Abuhelwa, MD1, S. Malhas, MD1, T. Saif, MD1, R. Assaly, MD2 1Division of Internal Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Division of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 *Corresponding author: Waleed.Khokher@utoledo.edu Published: 05 May 2023 Introduction: The use of stress ulcer prophylaxis (SUP) is routine in the intensive care unit (ICU) to prevent serious deleterious effects of gastrointestinal bleeding (GIB). The University of Toledo Translation Journal of Medical Sciences Internal Medicine Abstract, Department of Medicine Research Symposium UTJMS 2023 keywords: md1; toledo cache: translation-704.pdf plain text: translation-704.txt item: #127 of 204 id: translation-705 author: Khokher, Waleed title: Inhaled Pulmonary Vasodilators in COVID-19 Infection: : A Systematic Review and Meta-Analysis date: 2023-05-03 words: 353 flesch: 49 summary: The pre-IPVD P/F ratios were significantly lower compared to post-IPVD, but there was no significant difference between pre- and post-IPVD PEEP and lung compliance. *Corresponding author: Waleed.Khokher@utoledo.edu Published: 05 May 2023 Introduction: Inhaled pulmonary vasodilators (IPVD) have been previously studied in patients with non-coronavirus disease-19 (COVID-19) related acute respiratory distress syndrome (ARDS). keywords: md1; toledo cache: translation-705.pdf plain text: translation-705.txt item: #128 of 204 id: translation-706 author: Khokher, Waleed title: Pulse versus Non-pulse Steroid Regimens in Patients with Coronavirus Disease 2019: : A Systematic Review and Meta-Analysis date: 2023-05-03 words: 375 flesch: 47 summary: A Systematic Review and Meta-Analysis W. Khokher, MD1*, A. Beran, MD1, S. Iftikhar, MD1, S. Malhas, MD1, O. Srour, MD1, M. Mhanna, MD1, S. Bhuta, MD1, D. Patel, MD1, N. Kesireddy, MD1, C. Burmeister, MD1, E. Borchers, MS41, R. Assaly, MD2, F. Safi, MD1 1Division of Internal Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Division of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 *Corresponding author: Waleed.Khokher@utoledo.edu Published: 05 May 2023 Introduction: Therefore, we performed this meta-analysis to evaluate the role of PDS in COVID-19 patients compared to non-pulse steroids (NPDS). keywords: md1; medicine cache: translation-706.pdf plain text: translation-706.txt item: #129 of 204 id: translation-707 author: Khokher, Waleed title: Utility of Midodrine During the Recovery Phase of Shock: : A Systematic Review and Meta-Analysis date: 2023-05-03 words: 302 flesch: 46 summary: There was no significant difference in total duration of IVV use, IVV weaning time, ICU LOS, hospital LOS, or adverse events between the two groups. May 5; 11(1):e1-e1 Utility of Midodrine During the Recovery Phase of Shock: A Systematic Review and Meta-Analysis W. Khokher, MD1*, S. Iftikhar, MD1, A. Beran, MD1, C. Burmeister, MD1, S. Malhas, MD1, S. Malik, MD1, O. Srour, MD1, A. Abrahamian, MD1, A. Alharbi, MD1, N. Kesireddy, MD1, T. Saif, MD1, R. Assaly, MD2 1Division of Internal Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Division of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 keywords: md1 cache: translation-707.pdf plain text: translation-707.txt item: #130 of 204 id: translation-708 author: Kloster, Alex title: Heerfordt-Waldenstrom Syndrome: : A Case Report date: 2023-05-03 words: 341 flesch: 44 summary: 05 May 2023 Background: Heerfordt-Waldenstrom Syndrome(HWS) is a variant of sarcoidosis, which presents with swelling of the Parotid or salivary glands, facial nerve paralysis and anterior uveitis. The incidence is rare, with only 6% of sarcoidosis patients having parotid gland enlargement, and 5% of patients with cranial nerve palsy. keywords: medicine; toledo cache: translation-708.pdf plain text: translation-708.txt item: #131 of 204 id: translation-709 author: Pasadyn, Vanessa title: Applications of Inhalational Nitrous Oxide in Patients as an Alternative to Traditional Narcotics and Sedation Agents in the Emergency Department date: 2023-05-03 words: 352 flesch: 38 summary: This is the case of a 76-year-old woman who received nitrous oxide as analgesia for a shoulder reduction in the emergency department (ED). The goal of discussing this case is to emphasize the accessibility, efficacy, and safety of using nitrous oxide as a sedation agent in place of narcotics in the ED. keywords: toledo cache: translation-709.pdf plain text: translation-709.txt item: #132 of 204 id: translation-710 author: Pasadyn, Vanessa title: Assessing Resident Confidence in Placing a Central Venous Catheter Before and After a Simulation-Based Training Course date: 2023-05-03 words: 316 flesch: 37 summary: Before and After a Simulation-Based Training Course Vanessa Pasadyn, BA1*, Prajwal Hegde, BS1, Ola El Kebbi, MD1, Shaza Aouthmany, MD2 1Division of Internal Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Department of Emergency Medicine, The University of Toledo, Toledo, OH 43614 *Corresponding author: vanessa.pasadyn@rockets.utoledo.edu Published: 05 The University of Toledo Translation Journal of Medical Sciences Internal Medicine Abstract, Department of Medicine Research Symposium UTJMS 2023 keywords: toledo cache: translation-710.pdf plain text: translation-710.txt item: #133 of 204 id: translation-711 author: Patel, Neha title: Efficacy and Safety of Carotid Endarterectomy Versus Carotid Artery Stenting in Asymptomatic Severe Carotid Stenosis:: A Systematic Review and Meta-Analysis date: 2023-05-03 words: 354 flesch: 51 summary: Most studies compare outcomes between procedures in symptomatic patients; however, there is limited data comparing CEA to CAS in asymptomatic severe CS. Methods: We performed a literature search using PubMed, Embase, and Cochrane Library from inception through September 2021 to investigate the efficacy and safety of CAS compared to CEA in patients with asymptomatic severe CS. In patients with severe CS, both carotid endarterectomy (CEA) and carotid artery stenting (CAS) carry procedural risks, however they can restore patency and significantly reduce long-term stroke risk. keywords: toledo cache: translation-711.pdf plain text: translation-711.txt item: #134 of 204 id: translation-712 author: Patel, Neha title: Efficacy and Safety of Dual Antiplatelet Therapy Versus Direct Oral Anticoagulant Following Left Atrial Appendage Closure: : A Systematic Review and Meta-Analysis date: 2023-05-03 words: 380 flesch: 39 summary: The rates of DRT (RR 4.82, 95% CI 0.60-38.89, P=0.14), ischemic stroke (RR 1.23, 95% CI 0.38-4.05, P=0.73), and major bleeding (RR 1.34, 95% CI 0.50-3.65, P=0.56) were numerically lower in the DOAC group compared to DAPT group, although the differences did not reach statistical significance. Current guidelines recommend oral anticoagulant for 45 days, followed by dual antiplatelet therapy (DAPT) for 6 months. keywords: medicine; toledo cache: translation-712.pdf plain text: translation-712.txt item: #135 of 204 id: translation-713 author: pena, clarissa title: Ventricular Fibrillation Arrest after Blunt Chest Trauma in a 33-year-old Male, Commotio Cords? date: 2023-05-03 words: 344 flesch: 44 summary: We present a case in which ventricular fibrillation occurs in an older male athlete after blunt trauma. Case Presentation: A patient with no known medical history was brought to the emergency department after being found unconscious secondary to ventricular fibrillation after a soccer ball kick to the chest. keywords: toledo cache: translation-713.pdf plain text: translation-713.txt item: #136 of 204 id: translation-714 author: Rostad, Kylie title: Imipramine, Ulcerative Colitis and Linear Iga Bullous Dermatosis - : A Curious Triad date: 2023-05-03 words: 321 flesch: 37 summary: Linear IgA bullous dermatosis (LABD) is a rare autoimmune subepithelial vesiculobullous phenomenon caused by IgA antibodies against skin or mucosal basement membrane antigens. The temporal association of the imipramine initiation suggests that the medication may have acted as the trigger for LABD development during this initial flare of UC. keywords: iga cache: translation-714.pdf plain text: translation-714.txt item: #137 of 204 id: translation-715 author: Royfman, Rachel title: Worsening Pericardial Effusion Despite Intensive Hemodialysis date: 2023-05-03 words: 280 flesch: 32 summary: Complications of end- stage renal disease can include pericarditis and pericardial effusion. Some patients are able to successfully complete peritoneal dialysis at home, which is more convenient. keywords: toledo cache: translation-715.pdf plain text: translation-715.txt item: #138 of 204 id: translation-716 author: Rushdi, Hadeel I title: Mesenteric Mesothelial Cyst a Relatively Rare Complication of Peritoneal Dialysis and Intra-Abdominal Surgical Sequel, Case Presentation date: 2023-05-03 words: 559 flesch: 33 summary: We present a case of a patient with multiple cysts in which simultaneous sampling of different lesions yielded a sterile result and heavy growth of MRSA pointing to need for multiple sampling. In this case, we believe that the cysts were complications of previous peritoneal dialysis treatments and peritonitis and recommend synchronous sampling of multiple cysts since benign and infected cysts can coexist. keywords: https://dx.doi.org/10.46570/utjms.vol11-2023-716; md1 cache: translation-716.pdf plain text: translation-716.txt item: #139 of 204 id: translation-717 author: Sajdeya, Omar title: Efficacy and Safety of Intravascular Lithotripsy in the Treatment of Calcified Peripheral Artery Disease: : A Systematic Review and Meta-Analysis date: 2023-05-03 words: 323 flesch: 44 summary: IVL delivery success rate, pooled mean of acute lumen gain, minimal lumen diameter (MLD), and residual stenosis. Data regarding IVL clinical utility for PAD remain sparse. keywords: medicine; toledo cache: translation-717.pdf plain text: translation-717.txt item: #140 of 204 id: translation-718 author: Sajdeya, Omar title: Steroid-unresponsive Immune-mediated Hepatitis Induced by Durvalumab: : A Case Report date: 2023-05-03 words: 442 flesch: 38 summary: This requires careful monitoring of liver function tests in cancer patients on immune checkpoint inhibitors such as durvalumab, and demonstration of acute liver injury should be evaluated and managed promptly. Case Presentation: A 78-year-old female with a history of lung adenocarcinoma presented with abnormal liver function tests on routine screening after two cycles of durvalumab. keywords: medicine; toledo cache: translation-718.pdf plain text: translation-718.txt item: #141 of 204 id: translation-719 author: Sajdeya, Omar title: Racial Differences in Hypercholesterolemia Prevalence: : A Cross-sectional Study Using 2017-2018 National Health and Nutrition Examination Survey Data date: 2023-05-03 words: 282 flesch: 52 summary: May 5; 11(1):e1-e1 Racial Differences in Hypercholesterolemia Prevalence: A Cross-sectional Study Using 2017-2018 National Health and Nutrition Examination Survey Data Omar Sajdeya, MD1, Mohammad Safi, MD1, Ziad Abuhelwa, MD1, Wasef Sayeh MD1, Ragheb Assaly, MD2 1Division of Internal Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Division of Pulmonary and Critical Care Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 AA had a 24 % reduced risk of HCL diagnosis than whites after adjusting for age, Body Mass Index (BMI), diabetes, hypertension, and smoking; OR keywords: toledo cache: translation-719.pdf plain text: translation-719.txt item: #142 of 204 id: translation-72 author: Marco, Catherine A.; McGervey, Megan; Gekonde, Joan; Martin, Caitlin title: Pain scores among ED patients: correlation with desire for pain medication date: 2014-01-23 words: 3210 flesch: 61 summary: Pain scores usually effectively predicted which pa- tients desired pain medications. There was not a significant difference in pain scores between pa- tients who desired pain medication and those who were undecided (Wilcoxon p=0.2; Table 2). keywords: department; desire; emergency; medication; pain; patients; scores; study cache: translation-72.pdf plain text: translation-72.txt item: #143 of 204 id: translation-720 author: Sajdeya, Omar title: The Rate of Adverse Events of Sodium-Glucose Cotransporter 2 Inhibitors: : A Meta-Analysis of Randomized Clinical Trials date: 2023-05-03 words: 332 flesch: 44 summary: The University of Toledo Translation Journal of Medical Sciences Internal Medicine Abstract, Department of Medicine Research Symposium UTJMS 2023 We sought to assess the rate of adverse events with the use of SGLT2 inhibitors compared to placebo. keywords: medicine cache: translation-720.pdf plain text: translation-720.txt item: #144 of 204 id: translation-721 author: Salih, Ayman title: Knowledge, Attitude and Practices of Women Towards Breast Cancer in Arbaji Village, Gezira State, Sudan date: 2023-05-03 words: 345 flesch: 49 summary: The aim was to assess the knowledge, attitude, and practice towards early breast cancer detection tools. Breast cancer is a worldwide disease resulting in many deaths. keywords: toledo cache: translation-721.pdf plain text: translation-721.txt item: #145 of 204 id: translation-722 author: Sayeh, Wasef title: Full Thickness Versus Circular Peroral Myotomy in the Treatment of Esophageal Achalasia: : A Systematic Review and Meta-Analysis date: 2023-05-03 words: 397 flesch: 44 summary: Recent studies have investigated full thickness myotomy as a possible alternative. A Systematic Review and Meta- Analysis Wasef Sayeh, MD1*, Sami Ghazaleh, MD2, Azizullah Beran, MD1, Mohammad Safi, MD1, Dipen Patel, MD, MBA1, Justin Chaung, MD1, Saif-Eddin Malhas, MD1, Amna Iqbal, MD1, Ziad Abuhelwa, MD1, Waleed Khokher, MD1, Omar Sajdeya, MD1, Anas Alsughayer, MD1, Anas Renno, MD2, Ajit Ramadugu, MD2, Ali Nawras; MD2 1Division of Internal Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Division of Gastroenterology and Hepatology, Department of Medicine, The University of Toledo, Toledo, OH 43614 *Corresponding author: wasef.sayeh@utoledo.edu Published: 05 May 2023 Introduction: keywords: md1; toledo cache: translation-722.pdf plain text: translation-722.txt item: #146 of 204 id: translation-723 author: Sayeh, Wasef title: The Role of Tranexamic Acid Use in Reducing Mortality in Acute Upper GI Bleeding: : A Systemic Review and Meta-analysis date: 2023-05-03 words: 392 flesch: 54 summary: May 5; 11(1):e1-e1 The Role of Tranexamic Acid Use in Reducing Mortality in Acute Upper GI Bleeding: A Systemic Review and Meta-analysis Wasef Sayeh, MD1*, Sami Ghazaleh, MD2, Azizullah Beran, MD1, Mohammad Safi, MD1, David Farrow, MD1, Sudheer Dhoop, MD1, Dipen Patel, MD, MBA1, Justin Chaung, MD1, Waleed Khokher, MD1, Omar Sajdeya, MD1, Sara Stanley; DO2, Muhammad Aziz, MD2, Yaseen Alastal, MD1 1Division of , Department of Medicine, The University of Toledo, Toledo, OH 43614 2Division of, Department of Medicine, The University of Toledo, Toledo, OH 43614 3Division of, Department of Medicine, The University of Toledo, Toledo, OH 43614 The primary outcome was the all-cause of mortality rate. keywords: md1; toledo cache: translation-723.pdf plain text: translation-723.txt item: #147 of 204 id: translation-724 author: Shabpiray, Hoda title: A case of Extra Mammary Paget’s disease in a Geriatric Patient date: 2023-05-03 words: 444 flesch: 52 summary: The patient is diagnosed with cutaneous invasive adenocarcinoma. A 67-year-old male with a history of renal cell cancer status post left nephrectomy, diabetes, HTN and COPD presented with complaint of fatigue and 40 Ibs weight loss in 2 months. keywords: medicine; patient cache: translation-724.pdf plain text: translation-724.txt item: #148 of 204 id: translation-725 author: Shabpiray, Hoda title: Typical Imaging Findings Of TB in an Old Patient with IPF date: 2023-05-03 words: 433 flesch: 45 summary: May 5; 11(1):e1-e1 Typical Imaging Findings Of TB in an Old Patient with IPF H. Shabpiray1*, G. Merugu1, M. khorsand Askari1, N. Aslam1 1Division of Internal Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 *Corresponding author: hoda.shabpiray@utoledo.edu Published: 05 May 2023 Introduction: The diagnosis of pulmonary TB should be suspected in patients with relevant clinical manifestations and epidemiologic factors, history of TB infection, known or possible TB exposure, past or present residence in or travel to an endemic area. Anchoring bias may lead to delay in TB diagnosis, especially with atypical clinical presentations and imaging findings for TB. keywords: ipf cache: translation-725.pdf plain text: translation-725.txt item: #149 of 204 id: translation-726 author: Wang, Li title: A Case of Acute Myopericarditis in a Patient with Human Metapneumovirus (hMPV) Respiratory Infection date: 2023-05-03 words: 344 flesch: 44 summary: With the rising popularity of RPP tests in recent years, the increasing detection of hMPV infections will shed more light on its association with myopericarditis. *Corresponding author: Li.Wang5@utoledo.edu Published: 05 May 2023 Human metapneumovirus (hMPV), a relatively newly isolated virus, has emerged as one of the most common pathogens implicated in respiratory tract infections worldwide. keywords: medicine; toledo cache: translation-726.pdf plain text: translation-726.txt item: #150 of 204 id: translation-727 author: Yassen, Mohammand title: The Efficacy of Cardiac Myosin Inhibitors Versus Placebo in Patients with Symptomatic Hypertrophic Cardiomyopathy date: 2023-05-03 words: 362 flesch: 27 summary: Given the interplay between hypertrophic cardiomyopathy, elevated resting LVOT gradients (≥ 50 mm Hg) and heart failure and cardiovascular death, cardiac myosin inhibitors have recently emerged as a promising novel therapy to improve HCM-related outcomes by regulating myocardial relaxation and contractility, and thereby reducing intracavitary gradients. Conclusion: The use of cardiac myosin inhibitors in patients with symptomatic hypertrophic cardiomyopathy may confer both clinical and symptomatic benefits, at the possible expense of LV ejection fraction. keywords: lvot cache: translation-727.pdf plain text: translation-727.txt item: #151 of 204 id: translation-729 author: Yassen, Mohammad title: The Impact of Sacubitril / Valsartan Versus ACE/ARB Therapy on Functional Capacity in Heart Failure with Reduced Ejection Fraction date: 2023-05-03 words: 288 flesch: 30 summary: Given the correlation between subjective, patient-oriented measures and objective outcomes (for example, perceived symptomatic benefits promoting medication compliance), we sought to investigate the effect of ARNIs on exercise capacity in a patient-defined manner. Methods: We performed a literature search using PubMed, Embase, and Cochrane Library from inception through May 2022 to assess the impact of Sacubitril/Valsartan versus ACE therapy on physical activity tolerance in patients with heart failure with reduced ejection fraction. Conclusion: The use of ARNI compared to standard ACE therapy confers no statistically significant improvement in functional capacity in patients with heart failure with reduced ejection fraction. keywords: ejection cache: translation-729.pdf plain text: translation-729.txt item: #152 of 204 id: translation-730 author: Zerihun, Kirubel title: Efficacy and Safety of Insulin Icodec Versus Glargine U100- A meta-analysis of randomized controlled trials date: 2023-05-03 words: 388 flesch: 47 summary: Methods: We conducted a meta-analysis of randomized controlled trials that investigated the efficacy and safety of insulin icodec compared to glargine U100. From each clinical trial, we collected the number of patients who received icodec insulin and glargine U100. keywords: md1; toledo cache: translation-730.pdf plain text: translation-730.txt item: #153 of 204 id: translation-731 author: Abdul-Aziz, Omar title: Characterization of the Novel IQGAP1-Adrenergic Receptor Pathway in Lung Cancer date: 2023-05-03 words: 361 flesch: 38 summary: Our ongoing research will examine the effect of NE on protein levels and localizations in lung cancer and IQGAP1 mutant cells, as well as on the activity of signaling components downstream of IQGAP1. Next, we evaluated the effect of that dose on the gene expression levels of the two proteins and a downstream transcription factor, Nuclear Respiratory Factor 1 (NRF1), comparing response of lung cancer cells with normal lung epithelia by qRT-PCR. keywords: cancer; iqgap1 cache: translation-731.pdf plain text: translation-731.txt item: #154 of 204 id: translation-732 author: Abuhelwa, Ziad title: Hepatic Arterial Infusion Chemotherapy versus Trans-arterial Chemoembolization in Unresectable Hepatocellular Carcinoma: : A Systematic Review and Meta-Analysis date: 2023-05-03 words: 498 flesch: 41 summary: The median PFS was significantly longer in the HAIC group, ranging from 5.5 to 9.6 months, vs. TACE, ranging from 1.5 to 5.4 months (HR 0.45, 95% CI 0.26-0.79, P=0.001, I2=84.6%). HAIC was associated with significantly higher ORR (RR 2.70, 95% CI 2.06-3.55, P<0.001, I2=10.1%) and DCR (RR 1.42, 95% CI 1.19-1.70, P<0.001, I2=54.5%) and substantially reduced PD (RR 0.55, 95% CI 0.40-0.75, P<0.001, I2=56.6%) compared to TACE. keywords: tace; toledo cache: translation-732.pdf plain text: translation-732.txt item: #155 of 204 id: translation-733 author: Gurung, Deepti title: Probing Dynamics of 14-3-3: : A Potential Remedy for Pancreatic Cancer date: 2023-05-03 words: 354 flesch: 36 summary: *Corresponding author: Deepti.gurung@utoledo.edu Published: 05 May 2023 Introduction: Pancreatic cancer is the third-most-common cause of cancer-related deaths in the U.S. Drug development for pancreatic cancer has greatly advanced over the past decade. 14-3-3, therefore, is a potential anticancer target for the treatment of pancreatic cancer. keywords: cancer cache: translation-733.pdf plain text: translation-733.txt item: #156 of 204 id: translation-734 author: Osman, Mahasin title: The Dominant Negative IQGAP1(IR-WW) Domain as a Potential Therapy in Brain Cancer date: 2023-05-03 words: 240 flesch: 32 summary: Genetic mutant analysis in breast cancer cells has shown that the various domains of IQGAP1 have distinct effects on cell proliferation. These results are consistent with our previous findings in cervical cancer cells and present IQGAP1 as a clinical target in oncology. keywords: cancer cache: translation-734.pdf plain text: translation-734.txt item: #157 of 204 id: translation-735 author: Kaur, Jasskiran title: Predictors of 6-Month Mortality in Hospitalized COVID-19 Patients, : A Single-Institution Study date: 2023-05-03 words: 356 flesch: 34 summary: We included patients hospitalized with COVID-19 from University of Toledo Medical Center in Toledo, Ohio who were admitted within the timeframe of March 20,2020 to June 30, 2021. The University of Toledo Translation Journal of Medical Sciences UTJMS 2023 keywords: medicine; toledo cache: translation-735.pdf plain text: translation-735.txt item: #158 of 204 id: translation-736 author: Hamouda, Danae title: Immune Checkpoint Inhibitor Induced Hepatitis Injury: : Risk Factors, Outcomes, and Impact on Survival date: 2023-05-03 words: 323 flesch: 53 summary: ICIH was more frequent in women (p=0.038), in patients treated with combination ICIs (p<0.001), and when given as first line therapy (p=0.018). Few studies have evaluated risk factors and outcomes of patients who develop ICI-induced hepatitis (ICIH). keywords: icih cache: translation-736.pdf plain text: translation-736.txt item: #159 of 204 id: translation-737 author: Moussa, Rawan title: The Effects of the Chemotherapy Drug Cisplatin on Cell Migration date: 2023-05-03 words: 257 flesch: 37 summary: We hypothesized that chemotherapy drugs displace IQGAP1 from cell junctions and increase cell migration and dissociation of renal cells. In mammalian cells, cell migration plays a crucial role such as promoting organ development, sperm and egg motility, and wound healing. keywords: cell cache: translation-737.pdf plain text: translation-737.txt item: #160 of 204 id: translation-738 author: Nigro, Anthony title: Immunotherapeutic Interventions in Carcinoid Tumors date: 2023-05-03 words: 317 flesch: 25 summary: AdVince was tumoricidal to 100% of resected metastatic carcinoid tumor cells and delayed subcutaneous carcinoid tumor growth in mice. *Corresponding author: Anthony.Nigro@rockets.utoledo.edu Published: 05 May 2023 Introduction: Management of carcinoid tumors consists of pharmacological treatment and surgical resection. keywords: carcinoid; tumor cache: translation-738.pdf plain text: translation-738.txt item: #161 of 204 id: translation-739 author: Norris, Jordan title: Glioblastoma in Pregnant Patient with Pathologic and Exogenous Sex Hormone Exposure and Family History of High-Grade Glioma date: 2023-05-03 words: 367 flesch: 31 summary: Conclusion: Sex hormones and genetics likely exert influence on GBM development and progression that may compound with concurrence. May 5; 11(1):e1-e2 https://dx.doi.org/10.46570/utjms.vol11-2023-739 Haematology and Oncology Abstract, Department of Medicine Research Symposium Glioblastoma in Pregnant Patient with Pathologic and Exogenous Sex Hormone Exposure and Family History of High- Grade Glioma Jordan Norris, BS1*, Andrew Waack, BS1, Kathryn N. Becker, PhD1, Myles Keener, BS1, Jason L. Schroeder, MD2, Kevin Reinard, MD, Alistair Hoyt, MD, Danae Hamouda, MD1 1Division of Haematology and Oncology, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Department of Surgery, The University of Toledo, Toledo, OH 43614 *Corresponding author: Jordan.norris2@rockets.utoledo.edu Published: 05 May 2023 Introduction: Glioblastoma (GBM) incidence is higher in males, suggesting sex hormones may influence GBM tumorigenesis. keywords: gbm; toledo cache: translation-739.pdf plain text: translation-739.txt item: #162 of 204 id: translation-74 author: Koch, Terah; Al-Hashimi, Ibtisam; Koffman, Boyd M.; Deshpande, Abhishek; Khuder, Sadik A. title: Comorbidities associated with Sjögren's syndrome: Results from the Nationwide Inpatient Sample. date: 2014-04-02 words: 3738 flesch: 54 summary: Similar results were observed in a more recent cohort study, which estimated that the relative risk of de- veloping lymphoma was about 16-fold higher in SS patients than gen- eral population and that this risk increased over time and remained high, even 15 years after SS diagnosis (19). Secondary SS is closely associated with rheumatoid arthritis and is believed to have a different patho- genesis than primary SS (1). keywords: comorbidities; data; disease; lymphoma; patients; prevalence; risk; sjögren; study; syndrome cache: translation-74.pdf plain text: translation-74.txt item: #163 of 204 id: translation-740 author: Patel, Rayna title: Natural killer cells: a review of biology, : therapeutic potential and challenges in treatment of solid tumors date: 2023-05-03 words: 214 flesch: 27 summary: We will review our current knowledge of NK cells’ biology, and highlight the challenges facing NK cell antitumor strategies in solid tumors. Owing to their ability to engage tumor targets without the need of specific antigen, the therapeutic potential of NK cells has been extensively explored in hematological malignancies. keywords: toledo cache: translation-740.pdf plain text: translation-740.txt item: #164 of 204 id: translation-741 author: Patel, Rayna title: NF1 in Solid Tumors: : The Unknown Soldier of Tumor Suppressor Genes date: 2023-05-03 words: 241 flesch: 34 summary: However, the role of NF1 mutation in cancer has not been extensively studied, unlike other TSGs such as retinoblastoma (Rb), p53, Adenomatous Polyposis Coli (APC), or Phosphatase and Tensin Homolog (PTEN). Here we will discuss the molecular role of NF1 in cancer development and cancer-related cellular signaling. keywords: nf1 cache: translation-741.pdf plain text: translation-741.txt item: #165 of 204 id: translation-742 author: Rehman, Naveen title: A patient with Factor V Leiden mutation who developed a Pulmonary Embolism and Deep Vein Thrombosis post Covid date: 2023-05-03 words: 326 flesch: 30 summary: Case Presentation: A 53-year-old male with a past medical history of Factor V Leiden mutation on warfarin, atrial fibrillation, and Covid pneumonia complicated by hypoxic respiratory failure 6 weeks ago presented to the emergency department at the University of Toledo with a chief complaint of bilateral arm pain of 2 days duration, along with redness and swelling of his arms. Current literature outlines the incidence of Covid coagulopathy in patients without a previous history of hypercoagulability, however few sources have examined the consequences of Covid coagulopathy in patients with existing prothrombotic states. keywords: covid cache: translation-742.pdf plain text: translation-742.txt item: #166 of 204 id: translation-743 author: Aldhafeeri, Abdulaziz title: Daptomycin Associated Rhabdomyolysis with Concurrent Use of Atorvastatin date: 2023-05-03 words: 333 flesch: 29 summary: Conclusion: Daptomycin associated rhabdomyolysis is a rare and concerning side effect that require prompt discontinuation of the antibiotic. May 5; 11(1):e1-e1 Daptomycin Associated Rhabdomyolysis with Concurrent Use of Atorvastatin Abdulaziz Aldhafeeri, MD1*, Abdulmajeed Alharbi, MD1, Caleb Spencer, MD1, Bopp Benjamin, MD1, Kirubel Zerihun, MD1, Amna Al-Tkrit MD1 1Division of Hospital Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 keywords: daptomycin; md1 cache: translation-743.pdf plain text: translation-743.txt item: #167 of 204 id: translation-744 author: Gangwani, Manesh K. title: Bleeding Risk with Dual Antiplatelet Therapy and Gastrostomy Tube Placement: : A Systematic Review and Network Meta-Analysis date: 2023-05-03 words: 383 flesch: 39 summary: Methods: The following databases were searched: PubMed, Embase, Cochrane, and Web of Sciences to include comparative studies evaluating single antiplatelet (aspirin, clopidogrel), dual antiplatelet (DAPT, aspirin and clopidogrel), and no antiplatelet therapy. May 5; 11(1):e1-e2 Bleeding Risk with Dual Antiplatelet Therapy and Gastrostomy Tube Placement: A Systematic Review and Network Meta-Analysis Manesh Kumar Gangwani, MD1*, Muhammad Aziz, MD2, Abeer Aziz, MD1, Fnu Priyanka, MD1, Arti Patel, MD1, Umar Ghaffar, MD1, Simcha Weissman, MD1, Asif Mahmood, MD1, Wade Lee-Smith, MLS3, Toseef Javaid, MD1, Ali Nawras, MD2 Benjamin Hart, MD1 1Division of Hospital Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Division of Gastroenterology and Hepatology, Department of Medicine, The University of Toledo, Toledo, OH 43614 3Department of University Libraries, The University of Toledo, Toledo, OH 43614 keywords: md1; toledo cache: translation-744.pdf plain text: translation-744.txt item: #168 of 204 id: translation-745 author: Gangwani, Manesh title: Efficacy and Safety of EUS-directed Transgastric ERCP (EDGE) vs Laparoscopic-Assisted ERCP: : A Systematic Review and Meta-Analysis date: 2023-05-03 words: 429 flesch: 39 summary: A Systematic Review and Meta-Analysis Manesh Kumar Gangwani, MD1*, Hossein Haghbin, MD1, Fnu Priyanka, MD1, Yousaf Hadi, MD1, Dushyant Singh Dahiya, MD1, Faisal Kamal, MD1, Wade Lee-Smith, MLS2, Ali Nawras, MD3, Muhammad Aziz, MD3, Douglas G Adler, MD4 1Division of Hospital Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Division of Gastroenterology and Hepatology, Department of Medicine, The University of Toledo, Toledo, OH 43614 3Department of University Libraries, The University of Toledo, Toledo, OH 43614 4Director of Therapeutic Endoscopy and Director of Gastroenterology Fellowship Training Program University of Utah, School of Medicine, Salt Lake City, UT 84132 *Corresponding author: manesh.gangwani@utoledo.edu Published: 05 May 2023 Background: The altered anatomy in Roux-en-Y gastric bypass (RYGB) makes conventional Endoscopic retrograde cholangiopancreatography (ERCP) a technically challenging procedure. May 5; 11(1):e1-e2 Efficacy and Safety of EUS-directed Transgastric ERCP (EDGE) vs Laparoscopic-Assisted ERCP: keywords: toledo; university cache: translation-745.pdf plain text: translation-745.txt item: #169 of 204 id: translation-746 author: Gangwani, Manesh title: Fresh vs Frozen vs Lyophilized Fecal Microbiota transplant for Recurrent Clostridium Difficile Infection: : A Systematic Review and Network Meta-analysis date: 2023-05-03 words: 487 flesch: 46 summary: When compared to Fresh group, lower recovery rate was noted with both Frozen group (RD -0.06 95% CI -0.11-0.00, p=0.05) and Lyophilized group (RD -0.16 95% CI -0.27--0.05, p= 0.01). Fresh FMT was determined to be most successful with 93% efficacy 0.956 95 % CI (0.913 – 0.999) followed by Frozen with 88 % efficacy 0.902 95 % CI (0.857 – 0.947) and Lyophilized with 83% efficacy 0.828 95 % CI (0.745 – 0.910) . keywords: toledo cache: translation-746.pdf plain text: translation-746.txt item: #170 of 204 id: translation-747 author: Gayfield, Scott title: Myasthenic Crisis-Induced Takotsubo Cardiomyopathy: : What to Know date: 2023-05-03 words: 188 flesch: 29 summary: Myasthenic Crisis-Induced Takotsubo Cardiomyopathy: What to Know Scott Gayfield1*, Joshua Busken1, Sarmed Mansur1 1Division of Hospital Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 *Corresponding author: scott.gayfield@rockets.utoledo.edu Published: 05 May 2023 Myasthenia gravis (MG) is an autoimmune disorder in which antibodies are formed against post- synaptic nicotinic acetylcholine receptors that leads to impeded muscle contraction, and commonly affects the oculomotor muscles. MG can be complicated by myasthenic crisis (MC), a life-threatening exacerbation of myasthenic weakness that can lead to respiratory depression and possibly even death. keywords: medicine cache: translation-747.pdf plain text: translation-747.txt item: #171 of 204 id: translation-748 author: Issa, Rochell title: Urban-rural Disparities in Trends of Pulmonary Hypertension-Related Mortality in the United States, 2004-2019 date: 2023-05-03 words: 298 flesch: 42 summary: Rural counties had an overall significantly higher AAMR than urban counties, (rural: 10.75 Conclusion: Overall, our results indicate a gap in PH-associated healthcare services among those living in rural counties as compared to those living in urban counties within the US. keywords: toledo cache: translation-748.pdf plain text: translation-748.txt item: #172 of 204 id: translation-749 author: Abuhelwa, Ziad title: Do Zinc Supplements Reduce Mortality in Patients with COVID-19? A Systematic Review and Meta-Analysis date: 2023-05-03 words: 242 flesch: 41 summary: Results: A total of 6 studies (3 randomized clinical trials and 3 retrospective observational studies) that included 1,670 patients with COVID-19 (855 received zinc supplements vs. 812 received standard of care without zinc) were included in our systematic review. Method: PubMed/MEDLINE, EMBASE, and Cochrane databases were searched for studies that evaluated the clinical efficacy of zinc supplements in patients diagnosed with COVID-19. keywords: zinc cache: translation-749.pdf plain text: translation-749.txt item: #173 of 204 id: translation-750 author: Kammeyer, Joel title: Successful Administration of the Influenza Vaccine after Prior Serum Sickness in an HIV-Positive Patient date: 2023-05-03 words: 344 flesch: 36 summary: Serum sickness reaction to influenza vaccination has not previously been described in HIV+ Serum sickness reactions to vaccination have previously been described (2-6), and are treated with steroids and removal of the offending agent (1). keywords: toledo cache: translation-750.pdf plain text: translation-750.txt item: #174 of 204 id: translation-751 author: Esser, Katherine title: Daptomycin Induced Rhabdomyolysis and Subsequent Compartment Syndrome: : A Case Report date: 2023-05-03 words: 319 flesch: 22 summary: We present a case of a 56-year-old who developed compartment syndrome after daptomycin treatment for a S. aureus infection of a penile implant. Discussion: While compartment syndrome occurs secondarily to fractures in 75% of cases, it can also be a sequelae of soft tissue injuries, poor positioning during surgery, burns, vascular injuries, infections, and medication. keywords: toledo cache: translation-751.pdf plain text: translation-751.txt item: #175 of 204 id: translation-752 author: Kammeyer, Joel title: An Alprostadil Intracavernosal Injection Leading to a Psoas Muscle Abscess date: 2023-05-03 words: 347 flesch: 41 summary: Alprostadil is a synthetic prostaglandin E1 that can be self-administered via intracavernosal injection as a vasodilatory treatment for erectile dysfunction. The case offers an example of intracavernosal injection of alprostadil precipitating psoas muscle abscess, as opposed to more common cavernous or penile abscesses. keywords: toledo; university cache: translation-752.pdf plain text: translation-752.txt item: #176 of 204 id: translation-754 author: Kammeyer, Joel title: Fatal central pontine myelinolysis in a patient with uncontrolled HIV and normal sodium levels date: 2023-05-03 words: 331 flesch: 38 summary: Treatment of CPM with normal electrolytes includes addressing underlying causes that could precipitate metabolic derangement or increased permeability of the blood-brain barrier; this means management of underlying HIV even in a previously asymptomatic patient. While HIV affects the nervous system in up to 90% of patients, CPM remains rare. keywords: cpm; hiv cache: translation-754.pdf plain text: translation-754.txt item: #177 of 204 id: translation-755 author: Ibaraki, Makoto title: Impact of a Dedicated Outpatient Parenteral Antibiotic Therapy Clinic on Patient Outcomes date: 2023-05-03 words: 324 flesch: 31 summary: Future studies will have to continue examining the association between OPAT clinic visits and readmission along with other predictors to further improve the outcomes of OPAT patients. Logistic regression was applied to determine the association between readmission and visit to OPAT clinics while also examining covariates including sex, comorbidities, pathogen, and planned length of therapy. keywords: opat cache: translation-755.pdf plain text: translation-755.txt item: #178 of 204 id: translation-756 author: Kammeyer, Joel title: A Pathway of Distinction in Global Health – : A Professional Development Model to Prepare Medical Students as Future Global Health Leaders date: 2023-05-03 words: 573 flesch: 24 summary: The initial Pathway of Distinction in Global Health at the UTCOMLS consists of three foundational requirements for medical students. Medical students that complete all three requirements will be awarded a “Distinction in Global Health” upon graduation. keywords: health; toledo cache: translation-756.pdf plain text: translation-756.txt item: #179 of 204 id: translation-757 author: Kammeyer, Joel title: Early Infectious Diseases Consultation and Procalcitonin-Guided Therapy Limits Unnecessary Antibiotic Use in COVID-19 date: 2023-05-03 words: 446 flesch: 25 summary: https://dx.doi.org/10.46570/utjms.vol11-2023-757 https://dx.doi.org/10.46570/utjms.vol11-2023-757 mailto:joel.kammeyer@utoledo.edu https://dx.doi.org/10.46570/utjms.vol11-2023-757 UTJMS 11(1):e1-e2 https://dx.doi.org/10.46570/utjms.vol11-2023-757 2 ©2023 UTJMS Conclusion: Early consultation of an ID specialist and evaluation of PCT levels leads to significant reductions in inappropriate antibiotic use. We report a significant reduction in antibiotic use among COVID-19 patients in the setting of near-universal ID consultation in COVID-19 patients. keywords: covid-19; pct cache: translation-757.pdf plain text: translation-757.txt item: #180 of 204 id: translation-758 author: Nguyen, Dylan title: Protease-Inhibitor Binding Reveals Conformational Transition Mechanism date: 2023-05-03 words: 327 flesch: 33 summary: To confront HIV-1 protease drug resistance, Ghosh and colleagues developed protease inhibitors modeled after FDA approved HIV-1 protease inhibitor, Darunavir. In clinic, protease inhibitors are commonplace in the multi-drug regimens used by physicians to combat drug-resistant HIV strains with an unfortunate exchange for greater patient toxicity. keywords: protease cache: translation-758.pdf plain text: translation-758.txt item: #181 of 204 id: translation-759 author: Soewarna, Victoria title: Cellulosimicrobium Bacteremia in a Patient With Small Cell Lung Cancer: : Emergence of a New Gram-Positive Branching Rod date: 2023-05-03 words: 332 flesch: 28 summary: The blood cultures were identified as Cellulosimicrobium species on hospital day 11; his meropenem was discontinued and vancomycin was initiated. His neutropenia recovered on hospital day 2, but his fevers persisted and were attributed to pneumonia and possible bacteremia. keywords: hospital cache: translation-759.pdf plain text: translation-759.txt item: #182 of 204 id: translation-760 author: Starnes, Victoria title: CMV transverse myelitis in Unmanaged HIV Infection date: 2023-05-03 words: 324 flesch: 35 summary: Prior to the availability of antiretroviral therapy (ART), ATM was seen in patients with primary HIV infection due to opportunistic infections (2). We present a case of ATM attributed to cytomegalovirus secondary to uncontrolled HIV. keywords: hiv; toledo cache: translation-760.pdf plain text: translation-760.txt item: #183 of 204 id: translation-761 author: Starnes, Victoria title: Streptococcal Pneumoniae Mycotic Aneurysm: : A Rare Case of Disseminated Pneumococcal Disease in an Immunocompetent Host date: 2023-05-03 words: 324 flesch: 31 summary: Our case highlights the importance of vaccinations in preventing disseminated infection in even the healthiest of patients. Mycotic abdominal aortic aneurysm (MAAA) is a rare infection of the aortic wall that may progress to aortic rupture. keywords: case; infection cache: translation-761.pdf plain text: translation-761.txt item: #184 of 204 id: translation-762 author: Waack, Andrew title: Herpes Simplex Virus-1 Encephalitis Secondary to Whole Brain Radiation Therapy date: 2023-05-03 words: 323 flesch: 31 summary: Importantly, reported HSE cases following WBRT demonstrate an atypical presentation of encephalitis. Empirical intravenous acyclovir was initiated upon suspicion of possible HSE. keywords: hse cache: translation-762.pdf plain text: translation-762.txt item: #185 of 204 id: translation-763 author: Chen, Bohan title: MC1R Deficiency Enhances Th1 Response and Impairs Regulatory T Cell Homeostasis In Nephrotoxic Serum Nephritis date: 2023-05-03 words: 381 flesch: 25 summary: Moreover, shown by immunohistochemistry staining, the number of FoxP3+ regulatory T cells in the NTS nephritic kidneys was diminished in e/e mice, as compared with WT mice. The exacerbated NTS nephritis in e/e mice was associated with greater levels of autologous IgG2c and IgG3 either deposited in glomeruli or in sera. keywords: mice cache: translation-763.pdf plain text: translation-763.txt item: #186 of 204 id: translation-764 author: Chen, Bohan title: Negative Modulation of B Cell Activation by MC1R Signaling Protects Against Membranous Nephropathy date: 2023-05-03 words: 321 flesch: 27 summary: Results: MC1R KO exacerbated proteinuria, podocyte injury and glomerulopathy, associated with enhanced glomerular deposition of autologous IgG and the C5b-9 complement complex, denoting a sensitized autologous humoral immune response. Mechanistically, MC1R was evidently expressed in B lymphocytes, and negatively associated with B cell activation as revealed by gene set enrichment analysis. keywords: mc1r; rats cache: translation-764.pdf plain text: translation-764.txt item: #187 of 204 id: translation-765 author: Chen, Bohan title: Pharmacological Melanocortin 5 Receptor Activation Attenuates Glomerular Injury and Proteinuria in Rats with Puromycin Aminonucleoside Nephrosis date: 2023-05-03 words: 352 flesch: 20 summary: Treatment with MC5R-A attenuated urine protein excretion and mitigated the loss of podocyte marker proteins, resulting in improved podocyte ultrastructural changes. Results: Upon PAN injury, rats developed evident proteinuria on day 5, denoting an established nephrotic glomerulopathy. keywords: mc5r; pan cache: translation-765.pdf plain text: translation-765.txt item: #188 of 204 id: translation-767 author: Faleel, Dhilhani title: Computational and Experimental Analysis Reveals the Arachidonic Acid Metabolite 20-Hydroxyeicosatetraenoic Acid is a Novel Ligand of the Na/K-ATPase date: 2023-05-03 words: 373 flesch: 33 summary: This docking analysis predicted that 20-HETE and 5,14-20-HEDE interact with the NKA with similar binding free energy as cardiotonic steroids (Predicted binding free energies: telocinobufagin =-9.2; 20-HETE= -8.5 and 5,14-20-HEDE = -8.18). We further sought to test the ability of 20-HETE to stimulate NKA mediated signaling in renal proximal tubule cells. keywords: nka; toledo cache: translation-767.pdf plain text: translation-767.txt item: #189 of 204 id: translation-768 author: George, Jerrin title: A Case Series of Potential Cyanotoxin Exposure date: 2023-05-03 words: 259 flesch: 24 summary: Potential cyanotoxin exposure occurred while swimming in the Maumee River and Maumee State Park in Northwest OH during the summer months which coincide with peak HAB activity. Conclusion: Symptoms following potential cyanotoxin exposure coincide with multiple disease states representing an urgent need to develop specific diagnostic tests of exposure. keywords: exposure; toledo cache: translation-768.pdf plain text: translation-768.txt item: #190 of 204 id: translation-769 author: Zhang, Shungang title: Disruption of CD40 Results in Significantly Attenuated Renal Inflammation Following Glycerol-Induced Acute Kidney Injury date: 2023-05-03 words: 319 flesch: 30 summary: In addition, CD40 KO mice demonstrated significantly attenuated renal cortex gene expression of inflammatory markers IL1β, TGFβ1, and the fibrosis marker Col3a1 following AKI compared to wild-type (all p<0.05). We have also demonstrated significantly reduced pro-inflammatory and pro- fibrotic signaling in human CD40 KO renal proximal tubule epithelial cells. keywords: cd40 cache: translation-769.pdf plain text: translation-769.txt item: #191 of 204 id: translation-770 author: Al-Ataby, Harith A. title: Pleural plasmacytomas in a Patient with Multiple Myeloma Relapse date: 2023-05-03 words: 322 flesch: 46 summary: *Corresponding author: harith.al-ataby@utoledo.edu Published: 05 May 2023 Introduction: Pleural plasmacytoma in the setting of relapsed multiple myeloma (MM) is a rare yet serious condition, less than 10 cases have been reported in the literature. Discussion: Pleural plasmacytomas are extremely rare and account for around 3-6% of extramedullary disease in MM patients. keywords: plasmacytomas; pleural cache: translation-770.pdf plain text: translation-770.txt item: #192 of 204 id: translation-771 author: Al-Ataby, Harith title: Spontaneous Second Intercostal Artery Bleeding Complicated with Massive Hemothorax after Lower Limb Angioplasty Procedure date: 2023-05-03 words: 328 flesch: 48 summary: Discussion: Spontaneous intercostal artery bleeding is extremely rare and reported in patients with underlying disorders, such as neurofibromatosis type 1, SLE, coarctation of aorta, Kawasaki disease, or Ehler-Danlos. We believe that our patient is the first reported case of spontaneous second intercostal artery bleeding in absence of underlying disorders. keywords: artery cache: translation-771.pdf plain text: translation-771.txt item: #193 of 204 id: translation-772 author: Al-Tkrit, Amna title: Streptococcus intermedius - : An Uncommon Cause of Severe Pulmonary Infections in Immunocompetent Patients date: 2023-05-03 words: 325 flesch: 34 summary: For both cases pleural fluid analysis was consistent with empyema, culture was positive for Streptococcus intermedius. Streptococcus intermedius is commonly identified in abscesses of brain or liver. keywords: intermedius cache: translation-772.pdf plain text: translation-772.txt item: #194 of 204 id: translation-773 author: Borchers, Elizabeth title: Pulse Versus Nonpulse Steroid Regimens in Patients with Coronavirus Disease 2019: : A Systematic Review and Meta-Analysis date: 2023-05-03 words: 358 flesch: 43 summary: Therefore, we performed this meta-analysis to evaluate the role of PDS in COVID-19 patients compared to non-pulse steroids (NPDS). A Systematic Review and Meta-Analysis Elizabeth Borchers1*, Waleed Khokher2, Azizullah Beran2, Saffa Iftikhar2, Saif-Eddin Malhas2, Omar Srour2, Mohammed Mhanna2, Sapan Bhuta2, Dipen Patel2, Nithin Kesireddy2, Cameron Burmeister2, Ragheb Assaly1, Fadi Safi2 1Division of Pulmonology and Critical Care Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 2Division of Internal Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 *Corresponding author: Elizabeth.Borchers@rockets.utoledo.edu Published: 05 May 2023 Background: Systemic steroids are associated with reduced mortality in hypoxic patients with COVID- 19. keywords: medicine; toledo cache: translation-773.pdf plain text: translation-773.txt item: #195 of 204 id: translation-774 author: Busken, Joshua title: Pembrolizumab-induced Pneumonitis date: 2023-05-03 words: 218 flesch: 35 summary: Conclusion: Pembrolizumab induced pneumonitis is a rare but life-threatening complication. *Corresponding author: Joshua.busken@rockets.utoledo.edu Published: 05 May 2023 Introduction: Pembrolizumab is a monoclonal antibody targeting the anti-programmed death protein 1, which is present on the surface of T and B cells. keywords: pembrolizumab cache: translation-774.pdf plain text: translation-774.txt item: #196 of 204 id: translation-775 author: Carsel, Alex title: Reversal of Spironolactone-Induced Gynecomastia: : A Review and Case Report of Spironolactone-Induced Gynecomastia date: 2023-05-03 words: 327 flesch: 28 summary: All included studies demonstrated resolution of gynecomastia with discontinuation of spironolactone or replacement with eplerenone. Conclusion: Based on the results of this review, it is clear that there is a significant gap in the literature pertaining to the importance of identifying and treating gynecomastia, and reversing spironolactone- induced gynecomastia in patients with heart failure and cirrhosis. Eplerenone, a more selective aldosterone inhibitor compared to spironolactone, is cited as an alternative that can reverse spironolactone-induced gynecomastia in patients with hyperaldosteronism and cirrhosis. keywords: gynecomastia cache: translation-775.pdf plain text: translation-775.txt item: #197 of 204 id: translation-776 author: Crawford, Erin L> title: Use of Internal Standards to Develop Improved Methylation Detection in cfDNA date: 2023-05-03 words: 333 flesch: 36 summary: *Corresponding author: Erin.crawford@rockets.utoledo.edu Published: 05 May 2023 Detection of aberrant levels and patterns of methylation in circulating free genomic DNA (cfDNA) may be useful in predicting the presence of malignancy in a particular tissue or in monitoring known malignancies for recurrence or treatment resistance. Initial testing of an off-the-shelf IS yielded promising results but, technical error increased as methylation increased, likely due to suboptimal IS design and experimental conditions. keywords: methylation cache: translation-776.pdf plain text: translation-776.txt item: #198 of 204 id: translation-777 author: Kelly, Gavin title: Hyperpigmentation in Systemic Sclerosis date: 2023-05-03 words: 310 flesch: 35 summary: Results: Hyperpigmentation, particularly diffuse hyperpigmentation, has previously been linked to increase incidence of digital ulcers in SSc patients. It is hypothesized that increased endothelin-1 in SSc patients play a role in increased melanin synthesis in these patients. keywords: ssc cache: translation-777.pdf plain text: translation-777.txt item: #199 of 204 id: translation-778 author: Knight, Connor title: Working To Understand Familial Lung Cancer And Its Genetic Underpinnings date: 2023-05-03 words: 320 flesch: 49 summary: In this study we processed blood and buccal swab samples collected from affected and unaffected members of families with statistically significant enrichment for lung cancer. Mean DNA yield for blood samples was 301 µg and for buccal swabs was 8.86 µg. keywords: cancer; dna cache: translation-778.pdf plain text: translation-778.txt item: #200 of 204 id: translation-779 author: Meisler, Adam title: Iatrogenic Horner's Syndrome Due to Chest Tube Compression during Decortication date: 2023-05-03 words: 377 flesch: 42 summary: We present an iatrogenic cause of Horner’s syndrome due to compressive injury to the sympathetic chain by chest tube placement during decortication surgery. Discussion: Peripheral Horner’s syndrome is rare complication that can occur with intrathoracic surgeries and chest tube placement. keywords: toledo; university cache: translation-779.pdf plain text: translation-779.txt item: #201 of 204 id: translation-780 author: Noori, Zaid title: Fatal Case of Invasive Pulmonary Aspergillosis Post COVID-19 Pneumonia Due to Aspergillus Niger date: 2023-05-03 words: 509 flesch: 30 summary: The prevalence of COVID-19 associated pulmonary aspergillosis (CAPA) ranged from 0 to 33%. However, only few cases of Aspergillus niger are reported in the literature. keywords: md1; toledo cache: translation-780.pdf plain text: translation-780.txt item: #202 of 204 id: translation-781 author: Noori, Zaid title: Rare Case of Mantle Cell Lymphoma Presented as Malignant Pleural Effusion and Pleural Nodules date: 2023-05-03 words: 473 flesch: 48 summary: Pleural fluid that was obtained by thoracentesis was noted to be bloody and exudative (LDH: 750 Units/L, Protein 4.7 g/dL, Glucose 12 mg/dL, Lymphocytes 70%). Pleural involvement reported only in about one percent of cases. keywords: cell; lymphoma cache: translation-781.pdf plain text: translation-781.txt item: #203 of 204 id: translation-791 author: Dworkin, Lance D. title: Editorial date: 2023-05-03 words: 427 flesch: 37 summary: The opportunities I had as a trainee to listen and interact with leading investigators who came on campus are still some of my favorite memories from my entire academic career. Bringing outstanding investigators on campus helps to energize us and to remind us what can be accomplished through science to better understand our world and to advance medical therapeutics. keywords: toledo cache: translation-791.pdf plain text: translation-791.txt item: #204 of 204 id: translation-84 author: Brickman, Kristopher A.; Blair, Alex B.; Tamburrino, Marijo B.; Dzurik, Alexander D.; Xie, Hong; Smirnoff, Jennifer B.; Wang, Xin title: The Quantitative Minor Injury Scale: Pilot Study of a Scale to Measure Level of Minor Injury after Motor Vehicle Collisions date: 2014-07-10 words: 2931 flesch: 59 summary: A significant cor- relation (R=0.366; p=0.039; n=32) was found with the QMIS score and depression symptoms as measured by the CES-D. Conclusions: Results suggest the QMIS creates differentiation among a population of minor injury patients and may be useful in examining the relationship between minor injury and psychologi- cal conditions. Discussion The lack of quantitative evaluation of minor injury severity im- pedes research on post-MVC psychiatric symptoms. keywords: injuries; injury; patients; qmis; scale; score; severity; trauma cache: translation-84.pdf plain text: translation-84.txt