The University of Toledo Translation Journal of Medical Sciences 
Gastroenterology Abstract, Department of Medicine Research Symposium UTJMS 2023 May 5; 11(1):e1-e1 

Primary Gastric Squamous Cell Carcinoma with 
Concurrent H. Pylori Infection and Colonic Metastasis 
Bryanna Jay 1*, David Farrow1, Sara Stanley1, Anas Renno1, Toseef Javaid1 

1Division of Gastroenterology and Hepatology, Department of Medicine, The 
University of Toledo, Toledo, OH 43614 

*Corresponding author: Bryanna.Jay@utoledo.edu

Published: 05 May 2023 

Introduction: Primary gastric squamous cell carcinoma (PGSCC) is a rare, aggressive, malignancy that 
requires EGD with biopsy and pathology for diagnosis. H. pylori infection is a known risk factor for 
gastric malignancies but, only one case has been reported with an association between the two.     

Case Information:  This is a 66-year-old male, with no significant history, presented to the hospital 
with syncope, melena, fatigue, exertional dyspnea, and 50lb weight loss. Patient was found to have HGB 
of 3.2. CT abdomen showed a mass in the antrum of the stomach, most prominent posteriorly and 
around the greater curvature.  EGD revealed normal esophagus and a 15cm, oozing, fungating, and 
partially circumferential gastric mass located in the antrum, involving the entire posterior wall with 
extension into the greater curvature. The gastric mass was 5cm below the GE junction, without evidence 
of esophageal involvement. Biopsy of the mass revealed poorly differentiated SCC and Helicobacter 
pylori infection. Colonoscopy then revealed a 4 cm lesion which was confirmed to also be poorly 
differentiated SCC. PET scan showed known gastric and colonic mass with multiple enlarged and 
hypermetabolic perigastric and retroperitoneal lymph nodes consistent with metastasis.   

Discussion:  PGSCC is a rare form of gastric malignancy accounting for roughly 0.2% of primary 
gastric cancer reported. Compared to the more common gastric adenocarcinoma, SCC tends to be more 
aggressive with poorer outcomes. Unfortunately, the pathogenesis remains obscure, making early 
detection difficult. Additionally, metastasis to the colon is exceptionally rare with most cases 
metastasizing to liver, peritoneum, lung and bone. 

https://dx.doi.org/10.46570/utjms.vol11-2023-674 

https://dx.doi.org/10.46570/utjms.vol11-2023-674
mailto:Bryanna.Jay@utoledo.edu