The University of Toledo Translation Journal of Medical Sciences 
Internal Medicine Abstract, Department of Medicine Research Symposium UTJMS 2023 May 5; 11(1):e1-e1 

Efficacy and Safety of Intravascular 
Lithotripsy in the Treatment of Calcified 
Peripheral Artery Disease: A Systematic 
Review and Meta-Analysis 
Omar Sajdeya, MD1*, Anas Al Sughayer, MD1, Abdulmajeed Alharbi, MD1, 
Mohammad Safi, MD1, Ehab Eltahawy MD2

1Division of Internal Medicine, Department of Medicine, The University of Toledo, 
Toledo, OH 43614 
2Division of Cardiovascular Medicine, Department of Medicine, The University of 
Toledo, Toledo, OH 43614 

*Corresponding author: Omar.Sajdeya@utoledo.edu

Published: 05 May 2023 

Introduction: Intravascular lithotripsy (IVL) is a novel endovascular calcified peripheral artery disease 
(PAD) therapy technique. Data regarding IVL clinical utility for PAD remain sparse. We aimed to 
evaluate the safety and efficacy of IVL in managing calcified PAD. 

Methods: A comprehensive literature search (PubMed and Embase) through November 2020. Studies 
evaluating the clinical outcomes of IVL use in the management of calcified PAD. Primary outcomes: 
IVL delivery success rate, pooled mean of acute lumen gain, minimal lumen diameter (MLD), and 
residual stenosis. Secondary outcomes: 30- day major adverse effects (MAEs), (dissection, perforation, 
thrombus formation, and distal embolization rates).Meta-analyses were conducted using a random-effect 
model.  

Results: 7 studies (503 patients; 605 lesions). IVL success rate=99.6% (95% CI: 0.991-1.002). Pooled 
mean acute lumen gain=2.745 mm (95% CI: 1.826-3.664). Minimal diameter (MLD)= 4.017 (95% CI: 
2.910-5.123). Mean residual stenosis (MRS) = 21.737 mm (95% CI: 17.749-25.724).30-day MAE 
rate=0.018 (95% CI: -0.002-0.038), including dissection rate = 0.03 (95% CI: -0.003-0.047) and 
perforation rate = 0.004 (95% CI: -0.001-0.009). No studies reported embolization or thrombus 
formation.  

Conclusion: IVL is an effective and safe technique in managing calcified PAD, achieving significant 
improvement of acute lumen gain and low 30-day MAEs. However, further studies with large sample 
sizes are needed to determine the long-term efficacy and safety of IVL in PAD. 

https://dx.doi.org/10.46570/utjms.vol11-2023-717 

https://dx.doi.org/10.46570/utjms.vol11-2023-717
mailto:Omar.Sajdeya@utoledo.edu