The University of Toledo Translation Journal of Medical Sciences 
Hospital Medicine Abstract, Department of Medicine Research Symposium UTJMS 2023 May 5; 11(1):e1-e1 

https://dx.doi.org/10.46570/utjms.vol11-2023-747 

Myasthenic Crisis-Induced Takotsubo 
Cardiomyopathy: What to Know 
Scott Gayfield1*, Joshua Busken1, Sarmed Mansur1 

1Division of Hospital Medicine, Department of Medicine, The University of Toledo, 
Toledo, OH 43614 

*Corresponding author: scott.gayfield@rockets.utoledo.edu

Published: 05 May 2023 

Myasthenia gravis (MG) is an autoimmune disorder in which antibodies are formed against post-
synaptic nicotinic acetylcholine receptors that leads to impeded muscle contraction, and commonly 
affects the oculomotor muscles. MG can be complicated by myasthenic crisis (MC), a life-threatening 
exacerbation of myasthenic weakness that can lead to respiratory depression and possibly even death. 
Takotsubo cardiomyopathy (TTC) is a dilated cardiomyopathy that can mimic a myocardial infarction 
and causes reversible systolic dysfunction By themselves, MC has a mortality of 4% and TTC is 
approximately 2.4%. A review of 32 known cases of MC-associated TTC revealed a mortality of 15.6%, 
suggesting an unfortunate synergistic effect that significantly increases mortality. Here, we review the 
current cases and clinical patterns of 32 known cases of MC-associated TTC. 

https://dx.doi.org/10.46570/utjms.vol11-2023-747
mailto:scott.gayfield@rockets.utoledo.edu