The University of Toledo Translation Journal of Medical Sciences 
Infectious Diseases Abstract, Department of Medicine Research Symposium UTJMS 2023 May 5; 11(1):e1-e1 

Impact of a Dedicated Outpatient 
Parenteral Antibiotic Therapy Clinic on 
Patient Outcomes 
Makoto Ibaraki, MPH1*, Austin Cech1, Jennifer Hanrahan, DO, MSc1, Alicia 
Hochanadel, PharmD1, Joel A. Kammeyer, MD, MPH1

1Division of Infectious Diseases, Department of Medicine, The University of Toledo, 
Toledo, OH 43614 

*Corresponding author: Makoto.Ibaraki@rockets.utoledo.edu

Published: 05 May 2023 

Introduction: Outpatient parenteral antibiotic therapy (OPAT) can provide substantial benefits to both 
patients and the healthcare system. However, OPAT is also associated with risks that can end up 
harming patients, such as increasing the risk of rehospitalization and adverse events. We developed a 
predictive model of 30-day readmission among patients discharged on OPAT by using patient 
populations before and after the establishment of a dedicated OPAT clinic.   

Methods: A retrospective cohort study was conducted by using medical records. Logistic regression was 
applied to determine the association between readmission and visit to OPAT clinics while also 
examining covariates including sex, comorbidities, pathogen, and planned length of therapy. We 
hypothesized that at least one visit to the OPAT clinic would reduce the risk for readmission within 30 
days.    

Results: Among 368 patients, 240 (65.2%) received outpatient follow-up care at the OPAT clinic. 88 
(23.9%) were readmitted within 30 days. A multivariate logistic regression model indicated that an 
OPAT clinic visit was associated with a reduced risk of readmission compared to those that did not visit 
an OPAT clinic (odds ratio of 0.45 [95% confidence interval 0.27 – 0.78]) after adjusting for covariates 
that were selected using outcomes of univariate analyses. 

Conclusion: The predictive model for readmission developed in this study can be utilized to establish 
interventions to prevent readmission for OPAT patients. Future studies will have to continue examining 
the association between OPAT clinic visits and readmission along with other predictors to further 
improve the outcomes of OPAT patients. 

https://dx.doi.org/10.46570/utjms.vol11-2023-755 

https://dx.doi.org/10.46570/utjms.vol11-2023-755
mailto:Makoto.Ibaraki@rockets.utoledo.edu