item: #1 of 550 id: ujms-5598 author: Claesson-Welsh, Lena title: Oxygen sensing; a stunningly elegant molecular machinery highjacked in cancer date: 2020-06-24 words: 5438 flesch: 55 summary: Recent advances in the biology of tumour hypoxia with relevance to diagnostic practice and tissue-based research. Takeda N, Maemura K, Imai Y, Harada T, Kawanami D, Nojiri T, et al. keywords: cancer; expression; factor; hif; hif-1a; hypoxia; inducible; kaelin; oxygen; prolyl; pvhl; ratcliffe; semenza; sensing; tumour cache: ujms-5598.pdf plain text: ujms-5598.txt item: #2 of 550 id: ujms-5601 author: Lönnberg, Lena ; Ekblom-Bak, Elin ; Damberg, Mattias title: Reduced 10-year risk of developing cardiovascular disease after participating in a lifestyle programme in primary care date: 2020-02-20 words: 5998 flesch: 54 summary: We aimed to evaluate change in cardiovascular risk factors and Framingham 10-year risk score of developing CVD in men and women at high cardiovascular risk after participation in a structured lifestyle pro- gramme over 1 year. Conclusions: A structured lifestyle programme in primary care contributes to significant improvements of cardiovascular risk factors and the reduction of 10-year risk for CVD for both men and women at high cardiovascular risk. keywords: blood; care; cvd; disease; factors; lifestyle; patients; population; pressure; programme; risk; study; year; year risk cache: ujms-5601.pdf plain text: ujms-5601.txt item: #3 of 550 id: ujms-5604 author: Hodson, Leanne ; Parry, Sion A.; Cornfield, Thomas ; Charlton, Catriona ; Low, Wee Suan ; Green, Charlotte J. ; Rosqvist, Fredrik title: Using total plasma triacylglycerol to assess hepatic de novo lipogenesis as an alternative to VLDL triacylglycerol date: 2020-03-25 words: 3799 flesch: 54 summary: Using total plasma TAG would offer several advantages (in terms of cost, throughput, plasma volume, and time), but a direct comparison between DNL assessed in total plasma TAG and VLDL-TAG has not previously been performed. Therefore, in the present work, we used deuterated water to assess DNL in cir- culating total plasma TAG and compared this with DNL in isolated VLDL-TAG. keywords: dnl; dnlplasma; hepatic; oxford; plasma; subjects; tag; total; vldl cache: ujms-5604.pdf plain text: ujms-5604.txt item: #4 of 550 id: ujms-5605 author: Grønseth, Torstein ; Vestby, Lene K. title: Bioactive glass S53P4 eradicates Staphylococcus aureus in biofilm/planktonic states in vitro date: 2020-06-18 words: 7877 flesch: 62 summary: The same concentration with 14-day priming resulted in reduction in viable biofilm bacteria when using CLSM and BOAT. When BAG has reached its full antimicrobial effect it is as efficient as ciprofloxacin in vitro and could reduce the use of conventional antibiotics where S. aureus biofilm is suspected. keywords: aureus; bacteria; bag; biofilm; broth; ciprofloxacin; concentration; days; effect; granules; oslo; planktonic; strains; supernatant; test; tsb cache: ujms-5605.pdf plain text: ujms-5605.txt item: #5 of 550 id: ujms-5606 author: Rana, Sobia ; Mobin, Maha title: Association of the NEGR1 rs2815752 with obesity and related traits in Pakistani females date: 2020-05-18 words: 8053 flesch: 57 summary: ð1:88 � BMIÞ½ � � TG � 1:03½ � � 1:31 � HDL-C½ � Females VAI ¼ WC � 36:58 þ 1:89 � BMIð Þ½ � � TG � 0:81½ � � 1:52 � HDL-C½ � Males LAP ¼ WC–65ð Þ � TG Females LAP ¼ WC–58ð Þ � TG A general formula for both sexes was used to calculate the TyG index: TyG index ¼ Thus, genetic association studies should be performed in diverse populations, particularly in under-represented populations, to have a better understand- ing of genetic variants associated with a trait (17). keywords: association; bmi; controls; females; model; negr1; obesity; overweight; rs2815752; study; traits; variant cache: ujms-5606.pdf plain text: ujms-5606.txt item: #6 of 550 id: ujms-5607 author: Sydsjö, Gunilla ; Bladh, Marie ; Rindeborn, Katarina ; Hammar, Mats ; Rodriguez-Martinez, Heriberto ; Nedstrand, Elizabeth title: Being born preterm or with low weight implies a risk of infertility and premature loss of ovarian function; a national register study date: 2020-06-12 words: 4503 flesch: 57 summary: Low birth weight and risk of primary ovarian insufficiency A total of 44,087 women were born with low birth weight, and 952 (2.0%) of them had POI compared with 1.8% in women born with normal birth weight. Women diagnosed with POI were compared with women without this diagnosis with respect to being born small for gestational age, preterm, or with low birth weight. keywords: age; birth; insufficiency; ovarian; poi; preterm; risk; sga; study; weight; women cache: ujms-5607.pdf plain text: ujms-5607.txt item: #7 of 550 id: ujms-5608 author: Söderström, Lisa ; Rosenblad, Andreas ; Bergkvist, Leif ; Frid, Hanna ; Adolfsson, Eva Thors title: Dietary advice and oral nutritional supplements do not increase survival in older malnourished adults: a multicentre randomised controlled trial date: 2020-05-02 words: 7099 flesch: 53 summary: Oral nutritional supplements group All patients randomised to oral nutritional supplements were asked to drink 1–2 bottles per day, depending on the energy content of the supplement, to provide 400 kcal/day and 12–20 g protein. TF-IUPS200022 240..249 ORIGINAL ARTICLE Dietary advice and oral nutritional supplements do not increase survival in older malnourished adults: a multicentre randomised controlled trial Lisa S€oderstr€oma,b , Andreas Rosenbladc,d , Leif Bergkvista, Hanna Fride and Eva Thors Adolfssona aCentre for Clinical Research, Region V€astmanland, Uppsala University, V€asterås, Sweden; bDepartment of Food Studies, Nutrition and Dietetics, Uppsala University, Uppsala, Sweden; cDepartment of Statistics, Stockholm University, Stockholm, Sweden; dDepartment of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala University, Uppsala, Sweden; eDepartment of Child and Adolescence Psychiatry, V€astmanland Hospital, V€asterås, Sweden ABSTRACT Objectives: The study aimed to investigate the effect on survival after 6 months of treatment involv- ing individual dietary advice and oral nutritional supplements in older malnourished adults after dis- charge from hospital. keywords: advice; group; intervention; malnutrition; mortality; nutritional; ons; participants; patients; risk; study; supplements; survival cache: ujms-5608.pdf plain text: ujms-5608.txt item: #8 of 550 id: ujms-5626 author: Šileikienė, Virginija ; Gurskytė, Viktorija ; Zeleckienė, Ingrida ; Bernotienė, Elena ; Čibiras, Sigitas title: Pulmonary artery coil embolisation prevented tumour progression in a patient with advanced squamous cell lung carcinoma date: 2020-04-30 words: 3514 flesch: 52 summary: Unfortunately, 48.7–57% of non-small cell lung cancer (NSCLC) patients are diagnosed in late stages of the disease, when the options for treatment are limited and the chances of surviving are poor (2,5,6). Herbst RS, Morgensztern D, Boshoff C. The biology and manage- ment of non-small cell lung cancer. keywords: cancer; case; cell; embolisation; lung; patient; regression; sqclc; treatment; tumour; vilnius cache: ujms-5626.pdf plain text: ujms-5626.txt item: #9 of 550 id: ujms-5627 author: Griesinger, Georg title: Is progress in clinical reproductive medicine happening fast enough? date: 2020-05-04 words: 2030 flesch: 46 summary: IVF: a success story with some obvious limitations While the successes of modern assisted reproductive technol- ogy (ART) are obvious, so are the limitations: a high treat- ment failure rate per cycle, widespread use of IVF on a purely empirical basis, a lack of management options in case of age-related ovarian depletion, medical risks associated with ovarian stimulation and oocyte retrieval, a high psycho- logical burden associated with infertility itself but also with the treatment, high financial costs especially for couples not on reimbursement schemes, a high multiple pregnancy rate, insufficient knowledge on the long-term risks of some aspects of IVF treatment. Of note, all innovations to IVF treatment have to be judged from one perspective: will a new technology help more couples have a baby with less effort, less burden, less financial costs, and less parental and foetal risk? keywords: centres; hum; ivf; medicine; rcts; reproductive; technology; treatment cache: ujms-5627.pdf plain text: ujms-5627.txt item: #10 of 550 id: ujms-5628 author: Sjunnesson, Ylva title: In vitro fertilisation in domestic mammals—a brief overview date: 2019-12-13 words: 6882 flesch: 56 summary: Manipulation of domestic animal embryos and impli- cations for development. Apart from the polyspermy problem, pig oocytes and embryos are very sensitive to low temperatures. keywords: animals; bovine; cattle; development; embryos; fertilization; ivf; ivp; maturation; oocytes; pig; production; reprod; reproductive; research; species; spermatozoa; uppsala; vitro cache: ujms-5628.pdf plain text: ujms-5628.txt item: #11 of 550 id: ujms-5629 author: Lundin, Kersti ; Park, Hannah title: Time-lapse technology for embryo culture and selection date: 2020-02-25 words: 7208 flesch: 59 summary: Embryo transfer There is an on-going discussion about the best time for embryo transfer. Time-lapse technology for embryo culture and selection REVIEW ARTICLE Time-lapse technology for embryo culture and selection Kersti Lundin and Hannah Park Reproductive Medicine, Sahlgrenska University Hospital, G€oteborg, Sweden ABSTRACT Culturing of human embryos in optimal conditions is crucial for a successful in vitro fertilisation (IVF) programme. keywords: birth; blastocyst; cleavage; culture; day; development; embryo; hum; implantation; lapse; pregnancy; quality; reprod; selection; stage; time; transfer cache: ujms-5629.pdf plain text: ujms-5629.txt item: #12 of 550 id: ujms-5630 author: Björvang, Richelle D. ; Damdimopoulou, Pauliina title: Persistent environmental endocrine-disrupting chemicals in ovarian follicular fluid and in vitro fertilization treatment outcome in women date: 2020-02-25 words: 11671 flesch: 71 summary: State of the science of endocrine disrupting chemicals. Non-monotonic dose responses in studies of endocrine disrupting chemicals: keywords: c h; d n; d s; et al; g et; g h; h n; io n; l n; lip; lip et; n et; n g; n o; n w; o et; w et cache: ujms-5630.pdf plain text: ujms-5630.txt item: #13 of 550 id: ujms-5636 author: Wennberg, Anna-Lena title: Social freezing of oocytes: a means to take control of your fertility date: 2020-01-14 words: 3696 flesch: 62 summary: Creating more public awareness about age-linked fertility decline and elective egg freezing may help women reproduce at their own pace – to take control of their fertility. Creating more public awareness about age-linked fertility decline and elective egg freezing, also called social freezing, is therefore a key factor to help women reproduce at their own pace. keywords: age; egg; eggs; elective; fertility; freezing; medical; oocyte; women; years cache: ujms-5636.pdf plain text: ujms-5636.txt item: #14 of 550 id: ujms-5637 author: Westlander, Göran title: Utility of micro-TESE in the most severe cases of non-obstructive azoospermia date: 2020-04-01 words: 3900 flesch: 50 summary: There are several techniques to recover testicular sperm in patients with NOA. TESA can easily be repeated in a subsequent IVF cycle if sperm is retrieved and if cryo- preservation of testicular sperm is not possible. keywords: azoospermia; men; noa; patients; retrieval; sperm; tese; testicular cache: ujms-5637.pdf plain text: ujms-5637.txt item: #15 of 550 id: ujms-5638 author: Celada, Paula ; Bosch, Ernesto title: Freeze-all, for whom, when, and how date: 2020-04-14 words: 7131 flesch: 56 summary: Kyrou D, Fatemi HM, Popovic-Todorovic B, Van den Abbeel E, Camus M, Devroey P. Vaginal progesterone supplementation has no effect on ongoing pregnancy rate in hCG-induced natural fro- zen–thawed embryo transfer cycles. Nonetheless, as implantation probabilities are comparable to fresh embryo transfer in normo-responder patients, the freeze- all strategy has demonstrated no bene- fits overall. keywords: cryopreservation; cycles; day; embryo; embryo transfer; fertil; fet; freeze; fresh; frozen; hum; patients; progesterone; rates; reprod; steril; stimulation; transfer cache: ujms-5638.pdf plain text: ujms-5638.txt item: #16 of 550 id: ujms-5639 author: Rodriguez-Wallberg, Kenny A. ; Anastacio, Amandine ; Vonheim, Emelie ; Deen, Sandra ; Malmros, Johan ; Borgström, Birgit title: Fertility preservation for young adults, adolescents, and children with cancer date: 2020-05-01 words: 6357 flesch: 46 summary: In December 2019, the Practice Committee of the American Society of Reproductive Medicine stated that ovarian tissue cryopreservation for FP should no more be considered as experimental (23). Ovarian tissue cryopreservation and transplantation among alternatives for fertility preservation in the Nordic countries - compilation of 20 years of multicenter experience. keywords: cancer; cryopreservation; fertility; hospital; hum; karolinska; methods; oocytes; ovarian; patients; reprod; rodriguez; sperm; tissue; treatment; university; wallberg; women cache: ujms-5639.pdf plain text: ujms-5639.txt item: #17 of 550 id: ujms-5640 author: Vaiarelli, Alberto ; Cimadomo, Danilo ; Petriglia, Cecilia ; Confort, Alessandro ; Alviggi, Carlo ; Ubaldi, Nicolò; Ledda, Sergio ; Ferrero, Susanna ; Rienzi, Laura ; Ubaldi, Filippo Maria title: DuoStim – a reproducible strategy to obtain more oocytes and competent embryos in a short time-frame aimed at fertility preservation and IVF purposes. A systematic review date: 2020-04-25 words: 12250 flesch: 64 summary: Therefore, in in vitro fertilization (IVF), novel protocols regarding ovarian stimulation have been theorized based on the use of gonadotrophins to prompt the growth of antral follicles at any stage of the menstrual cycle. These unconventional protocols for ovarian stimulation aim at a more efficient management of poor-prognosis patients, otherwise exposed to conflicting outcomes after conventional approaches. keywords: ay g; ay þ; cycle; duostim; et al; g n; m g; n rh; n t; oocytes; ovarian; patients; reprod; stimulation cache: ujms-5640.pdf plain text: ujms-5640.txt item: #18 of 550 id: ujms-5641 author: Castillo, Juan Carlos ; Haahr, Thor ; Martínez-Moya, María ; Humaidan, Peter title: Gonadotropin-releasing hormone agonist for ovulation trigger – OHSS prevention and use of modified luteal phase support for fresh embryo transfer date: 2020-05-04 words: 6597 flesch: 52 summary: Haahr T, Roque M, Esteves SC, Humaidan P. GnRH agonist trigger and LH activity luteal phase support versus hCG trigger and con- ventional luteal phase support in fresh embryo transfer IVF/ICSI cycles—a systematic PRISMA review and meta-analysis. However, when compared to the natural cycle, the total amount of gonado- trophins released during the GnRHa-triggered surge is signifi- cantly reduced, but a possible advantage of GnRHa trigger over hCG trigger is the simultaneous induction of an FSH (follicle-stimulating hormone) surge (8). keywords: agonist; cycles; dose; embryo; gnrha; gnrha trigger; hcg; hormone; hum; luteal; ohss; patients; phase; reprod; risk; support; transfer; trigger cache: ujms-5641.pdf plain text: ujms-5641.txt item: #19 of 550 id: ujms-5642 author: Castillo, Juan Carlos ; Haahr, Thor ; Martínez-Moya, María ; Humaidan, Peter title: Gonadotropin-releasing hormone agonist ovulation trigger—beyond OHSS prevention date: 2020-03-25 words: 5715 flesch: 55 summary: Sismanoglu A, Tekin HI, Erden HF, Ciray NH, Ulug U, Bahceci M. Ovulation triggering with GnRH agonist vs. hCG in the same egg donor population undergoing donor oocyte cycles with GnRH antagonist: a prospective randomized cross-over trial. Ovulation trigger in oocyte donation cycles According to the European IVF-monitoring Consortium, oocyte donation cycles account for up to 32.4% of all ART treatments in some countries (36). keywords: agonist; cycles; fsh; gnrha; gonadotropin; hcg; ivf; maturation; oocyte; ovarian; patients; reprod; syndrome; trigger cache: ujms-5642.pdf plain text: ujms-5642.txt item: #20 of 550 id: ujms-5643 author: Nardo, Luciano ; Chouliaras, Spyridon title: Adjuvants in IVF — evidence for what works and what does not work date: 2020-05-07 words: 7631 flesch: 51 summary: The quality of evidence was considered low to indicate improved IVF outcomes (28). A more recent systematic review and meta-analysis of the available evidence regarding immunotherapy (38) identified 15 suitable RCTs, but only 2 of those were RCTs regarding IVIg in women undergoing IVF treatment with a history of RIF. keywords: analysis; benefit; cells; cpr; dhea; embryo; evidence; failure; implantation; ivf; meta; outcomes; patients; recurrent; reproductive; review; studies; treatment; use; women cache: ujms-5643.pdf plain text: ujms-5643.txt item: #21 of 550 id: ujms-5644 author: Bergh, Christina ; Wennerholm, Ulla-Britt title: Long-term health of children conceived after assisted reproductive technology date: 2020-02-26 words: 4831 flesch: 55 summary: In general, there are no alarming results for ART children, although there might be an increased risk for children born after frozen/ thawed cycles. This is the case, despite the fact that large cohorts of ART children and adolescents now exist. keywords: art; art children; association; children; cohort; conception; ivf; reproductive; risk; singletons; studies; study cache: ujms-5644.pdf plain text: ujms-5644.txt item: #22 of 550 id: ujms-5645 author: Wennerholm, Ulla-Britt ; Bergh, Christina title: Perinatal outcome in children born after assisted reproductive technologies date: 2020-03-03 words: 8143 flesch: 59 summary: Henningsen AA, Wennerholm UB, Gissler M, Romundstad LB, Nygren KG, Tiitinen A, et al. Risk of stillbirth and infant deaths after assisted reproductive technology: a Nordic study from the CoNARTaS group. Opdahl S, Henningsen AA, Tiitinen A, Bergh C, Pinborg A, Romundstad PR, et al. Risk of hypertensive disorders in pregnan- cies following assisted reproductive technology: a cohort study from the CoNARTaS group. keywords: analysis; art; birth; children; defects; embryo; hum; icsi; meta; outcomes; perinatal; pregnancies; preterm; reprod; review; risk; singletons; studies; transfer; versus cache: ujms-5645.pdf plain text: ujms-5645.txt item: #23 of 550 id: ujms-5653 author: Pichtchoulin, Sara ; Selmeryd, Ingrid ; Freyhult, Elisabeth ; Hedberg, Pär ; Selmeryd, Jonas title: Staphylococcus aureus bacteremia and cardiac implantable electronic devices in a county hospital setting: a population-based retrospective cohort study date: 2021-03-05 words: 5904 flesch: 50 summary: In-hospital death occurred in 19/61 (31%) cases, 34/61 (56%) cases were discharged with CIED device re- tained, and 8/61 (13%) cases were discharged after device removal. Discharged after CIED removal Of the 42/61 (69%) cases discharged from hospital, the CIED was explanted in 8/42 (19%) cases. keywords: aureus; cases; clinical; device; doi; hospital; management; patients; removal; sab; staphylococcus; study; sweden cache: ujms-5653.pdf plain text: ujms-5653.txt item: #24 of 550 id: ujms-5660 author: Eklund, Michael; Hellberg, Olof; Furuland, Hans; Cao, Yang; Nilsson, Erik title: Effects of spironolactone on extrasystoles and heart rate variability in haemodialysis patients: a randomised crossover trial date: 2021-01-25 words: 5488 flesch: 48 summary: Effects of spironolactone on extrasystoles and heart rate variability in haemodialysis patients: a randomised crossover trial Michael Eklunda, Olof Hellberga, Hans Furulandb, Yang Caoc,d and Erik Nilssone,f aDepartment of Internal Medicine, School of Medical Sciences, Örebro University, Örebro, Sweden; bDepartment of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden; cClinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden; dUnit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; eDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; fSchool of Medical Sciences, Örebro University, Örebro, Sweden ABSTRACT Background: Spironolactone treatment reduces mortality in haemodialysis (HD) patients. Conclusion: Spironolactone treatment increases PVCs in HD, indicating a possible proarrhythmic effect. keywords: beat; doi; effects; frequency; heart; hrv; intervals; medical; participants; patients; spironolactone; study; treatment; örebro cache: ujms-5660.pdf plain text: ujms-5660.txt item: #25 of 550 id: ujms-5665 author: Taube, Adam title: Observations by a statistical watchdog date: 2021-02-08 words: 4712 flesch: 55 summary: Also, during the last decades, a number of national registers have been created, which sometimes are used for statistical analyses made by people with scanty knowledge of statistical principles (19). Observations by a statistical watchdog Adam Taube Department of Statistics, Uppsala University, PO Box 513, SE-75120 Uppsala ABSTRACT During more than five decades, the author has kept a critical eye on how statistical methods are (mis-) used in medical research. keywords: analysis; data; läkartidningen; medical; methods; number; paper; statistical; taube cache: ujms-5665.pdf plain text: ujms-5665.txt item: #26 of 550 id: ujms-5670 author: Delbaere, Ilse ; Verbiest, Sarah ; Tydén, Tanja title: Knowledge about the impact of age on fertility: a brief review date: 2020-01-22 words: 6905 flesch: 57 summary: Fertility awareness among health care providers and medical students Not only is there a lack of fertility awareness in the general population of university students, there is a lack of know- ledge among medical students and health care providers as well. An experimental evaluation of the benefits and costs of providing fertility information to adolescents and emerging adults. keywords: age; awareness; care; children; counselling; fertility; health; information; knowledge; life; medical; reproductive; students; university; women cache: ujms-5670.pdf plain text: ujms-5670.txt item: #27 of 550 id: ujms-5671 author: Skoog Svanberg, Agneta ; Sydsjö, Gunilla ; Lampic, Claudia title: Psychosocial aspects of identity-release gamete donation – perspectives of donors, recipients, and offspring date: 2019-12-05 words: 7172 flesch: 59 summary: ARTICLE HISTORY Received 7 October 2019 Revised 19 November 2019 Accepted 19 November 2019 KEYWORDS Disclosure; donor offspring; gamete donation; open- identity donors Introduction The desire to have a child is based both on psychological and social reasons. Miettinen A, Rotkirch A, Suikkari AM, S€oderstr€om-Anttila V. Attitudes of anonymous and identity-release oocyte donors towards future contact with donor offspring. keywords: child; conception; contact; donation; donor; family; identity; information; offspring; oocyte; release; sperm; study cache: ujms-5671.pdf plain text: ujms-5671.txt item: #28 of 550 id: ujms-5672 author: Gunnarsson Payne, Jenny ; Korolczuk, Elzbieta ; Mezinska, Signe title: Surrogacy relationships: a critical interpretative review date: 2020-02-19 words: 8197 flesch: 47 summary: Second, we have con- structed a table of ‘ideal types’ of surrogacy relationships, based on the empirical findings. Teman E. The social construction of surrogacy research: an anthropological critique of the psychosocial scholarship on surro- gate motherhood. keywords: child; contact; contexts; countries; e.g.; expectations; justice; narratives; parents; pregnancy; relationships; reproductive; research; review; studies; surrogacy; surrogate cache: ujms-5672.pdf plain text: ujms-5672.txt item: #29 of 550 id: ujms-5673 author: Asplund, Kjell title: Use of in vitro fertilization—ethical issues date: 2019-11-05 words: 7139 flesch: 54 summary: The focus of this article is on IVF practices and ethical dis- cussions in Europe and English-speaking countries. John Biggers, one of the IVF pioneers, recalled memories from a public hearing arranged by the state of Virginia: ‘The entire meeting turned out to be a shouting match, the two groups [“pro-lifers” and IVF proponents] hurl- ing insults at each other’ (1). keywords: age; countries; egg; embryos; ethics; health; human; ivf; medical; principle; public; reproduction; surrogacy; use; values; women cache: ujms-5673.pdf plain text: ujms-5673.txt item: #30 of 550 id: ujms-5674 author: Holte, Jan ; Brodin, Thomas title: Are we looking under the lamp although we know the lost key is somewhere else? Or is it just about the egg? date: 2020-05-18 words: 3157 flesch: 58 summary: Ups J Med Sci 2020;125:144–51. Ups J Med Sci 2020;125:192–99. 26. keywords: embryo; factors; ivf; med; oocyte; reprod; results; sci; ups cache: ujms-5674.pdf plain text: ujms-5674.txt item: #31 of 550 id: ujms-5675 author: Lindblad-Toh, Kerstin title: What animals can teach us about evolution, the human genome, and human disease date: 2020-02-14 words: 7436 flesch: 55 summary: Comparative genetics Complexity of human disease genetics After the generation of the human genome, lots of effort went into detecting variation in the human genome. Abstract Introduction Human disease—early studies Tools have transformed genetics Comparative genomics Sequencing the human genome Mouse and rat genomes Dog genome Monodelphis genome and vertebrate evolution Stickleback, cichlids, and herring—good examples of environmental adaptations Mammals help annotate the human genome All is not protein-coding genes More than 240 mammals for single base resolution constraint in mammalian genomes Comparative genetics Complexity of human disease genetics The dog as a model for human disease Obsessive-compulsive disorders (OCD) shares a common aetiology between dogs and humans Taking the next step Sequencing technologies change the way we can analyse most species on earth Mammalian constraint and its use for understanding disease in many mammals Utilising the canine model for clinical trials Conclusion Acknowledgements Disclosure statement References keywords: analysis; complex; data; disease; dogs; elements; et al; evolution; genes; genetics; genome; human; loci; mammalian; mammals; nature; regions; sequence; sequencing; species cache: ujms-5675.pdf plain text: ujms-5675.txt item: #32 of 550 id: ujms-5678 author: Edvinsson, Åsa ; Hoyer, Angela ; Hansson, Malin ; Kunovac Kallak, Theodora ; Sundström-Poromaa, Inger ; Skalkidou, Alkistis ; Lager, Susanne title: Placental glucocorticoid receptors are not affected by maternal depression or SSRI treatment date: 2020-01-21 words: 4813 flesch: 51 summary: Placental glucocorticoid receptor levels and activ- ity were tested for normality using the Shapiro–Wilk test; dif- ferences between the groups were evaluated by one-way ANOVA test, t test, Kruskal–Wallis, or Mann–Whitney U test as appropriate. We did not observe an effect of maternal SSRI treatment upon placental glucocorticoid receptor levels. keywords: depressive; levels; nr3c1; placental; pregnancy; protein; receptor; ssri; stress; study; symptoms; treatment; university; uppsala; women cache: ujms-5678.pdf plain text: ujms-5678.txt item: #33 of 550 id: ujms-5679 author: Carlsson, Axel C. ; Nowak, Christoph ; Lind, Lars ; Östgren, Carl Johan ; Nyström, Fredrik H. ; Sundström, Johan ; Carrero, Juan Jesus ; Riserus, Ulf ; Ingelsson, Erik ; Fall, Tove ; Ärnlöv, Johan title: Growth differentiation factor 15 (GDF-15) is a potential biomarker of both diabetic kidney disease and future cardiovascular events in cohorts of individuals with type 2 diabetes: a proteomics approach date: 2019-12-05 words: 6251 flesch: 51 summary: As a second step, we used the whole cohort to perform additional multivariable modelling adjusted for cohort (ran- dom effects), age, sex, glucose control/diabetes factors (HbA1c, oral antidiabetic drug use, and insulin treatment), and cardiovascular risk factors (cardiovascular disease at baseline, low-and high-density lipoprotein cholesterol, trigly- cerides, BMI, cardiovascular disease at baseline, systolic and diastolic blood pressure, antihypertensive therapy, statins, and smoking status). Growth differentiation factor 15 (GDF-15) is a potential biomarker of both diabetic kidney disease and future cardiovascular events in cohorts of individuals with type 2 diabetes: a proteomics approach ARTICLE Growth differentiation factor 15 (GDF-15) is a potential biomarker of both diabetic kidney disease and future cardiovascular events in cohorts of individuals with type 2 diabetes: a proteomics approach Axel C. Carlssona, Christoph Nowaka, Lars Lindb, Carl Johan €Ostgrenc, Fredrik H. Nystr€omc, Johan Sundstr€omb, Juan Jesus Carrerod, Ulf Riseruse , Erik Ingelssonf,g,h,i, Tove Falli and Johan €Arnl€ova,j aDepartment of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden; bDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden; cDepartment of Medical and Health Sciences, Link€oping University, Link€oping, Sweden; dDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; eDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden; fDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; gStanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; hStanford Diabetes Research Center, Stanford University, Stanford, CA, USA; iMolecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; jSchool of Health and Social Studies, Dalarna University, Falun, Sweden ABSTRACT Background: Diabetic kidney disease (DKD) is a leading risk factor for end-stage renal disease and is one of the most important risk factors for cardiovascular disease in patients with diabetes. keywords: cardiovascular; diabetes; disease; dkd; factors; gdf-15; kidney; patients; proteins; risk; study; sweden; type; uppsala cache: ujms-5679.pdf plain text: ujms-5679.txt item: #34 of 550 id: ujms-5680 author: Wang, Ziqiong ; Xu, Ying ; Liao, Hang ; Chen, Xiaoping ; He, Sen title: U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients date: 2020-02-04 words: 5412 flesch: 60 summary: Restricted cubic spline In the multivariable-adjusted spline (adjusted for the same variables as in model 5), there was a U-shaped association between SUA concentrations and all-cause mortality and HCM-related mortality, with a nadir of risk at SUA around 300 mmol/L. Deviation of SUA from 300 mmol/L was signifi- cantly associated with higher mortality risk (Figure 2(A,B)). By grouping SUA into tertiles, intracategory variations in mortality risk could not be detected, probably leading to a failure of examining the influence of very low and very high SUA concentrations on mortality. keywords: acid; cause; cause mortality; concentrations; hcm; mmol; mortality; patients; study; sua; uric cache: ujms-5680.pdf plain text: ujms-5680.txt item: #35 of 550 id: ujms-5694 author: Semenas, Egidijus ; Lönnemark, Maria ; Dahlman, Pär ; Hultström, Michael; Eriksson, Mats title: Analgesic effects of dexmedetomidine and remifentanil on periprocedural pain during percutaneous ablation of renal carcinoma date: 2020-02-18 words: 4292 flesch: 46 summary: Incidence of multiple sporadic renal cell carcinomas in patients referred for renal radiofrequency ablation: implications for imag- ing follow-up. Radiofrequency ablation is indicated in T1 tumours (i.e. the cancer cells are only growing in the most superficial layer of tissue, without growing into deeper tissues) in patients with advanced age and significant co-morbidities, including reduced renal function as well as single kidney. keywords: ablation; carcinoma; dexmedetomidine; pain; patients; procedure; radiofrequency; remifentanil; study; treatment; uppsala cache: ujms-5694.pdf plain text: ujms-5694.txt item: #36 of 550 id: ujms-5695 author: Ruge, Toralph ; Carlsson, Axel C. ; Hellström, Magnus ; Wihlborg, Per ; Undén, Johan title: Is medical urgency of elderly patients with traumatic brain injury underestimated by emergency department triage? date: 2020-01-28 words: 4947 flesch: 60 summary: Conclusion: Elderly patients with isolated TBI are managed differently than younger patients, which could be due to an under-triage of elderly patients by RETTS-A. ARTICLE HISTORY Received 26 August 2019 Revised 13 December 2019 Accepted 15 December 2019 KEYWORDS Elderly patients; emergency department; RETTS-A; traumatic brain injury Introduction Traumatic brain injury (TBI) is one of the leading causes of death in the Western world, with an incidence between 47 and 849 per 100,000 habitants per year (1,2). This may lead to under-triage of elderly patients and could also explain the poor performance of triage tools in elderly trauma patients (8). TBI in older adults is associated with worse outcome when compared to younger adults (2). keywords: ais; hospital; injury; level; mortality; patients; priority; retts; study; tbi; triage cache: ujms-5695.pdf plain text: ujms-5695.txt item: #37 of 550 id: ujms-5696 author: Andersson, Arne; Espes, Daniel ; Lau Börjesson, Joey title: Further improvement of our metrics—will plan S affect them? date: 2019-12-17 words: 1798 flesch: 63 summary: Open access journals: impact factors. Open access journals IF 2009 IF 2018 Factor change PLoS One 4.351 2.776 0.64 PLoS Medicine 13.050 11.048 0.85 PLoS Biology 12.916 8.386 0.65 BMC Biology 5.636 6.723 1.19 BMC Medicine 3.985 8.285 2.08 Virology Journal 2.435 2.464 1.01 Chinese Medical Journal 0.952 1.555 1.63 Swiss Medical Weekly 1.681 1.821 1.08 Journal of Translational Medicine 3.407 4.098 1.20 Upsala Journal of Medical Sciences 0.733 2.747 3.75 Mean factor change: 1.41 ± 0.30. keywords: access; figures; impact; journal; year cache: ujms-5696.pdf plain text: ujms-5696.txt item: #38 of 550 id: ujms-5697 author: Nilsson, Anders S. title: Pharmacological limitations of phage therapy date: 2019-11-14 words: 9824 flesch: 57 summary: This is not studied empirically in detail in the context of phage therapy, but there is an indica- tion that phage titres from the second and following cycles of phage infection become unexpectedly low in in vitro experiments (45,46). Imaging of phage infection in vivo, e.g. during phage therapy of mice, has not been car- ried out, although the technique has been established (94). keywords: adsorption; bacteria; bacteriophage; development; infection; low; microbiol; models; number; phage; phage therapy; rate; research; resistance; therapy; titre; treatment; trials; variation cache: ujms-5697.pdf plain text: ujms-5697.txt item: #39 of 550 id: ujms-5705 author: Andersson, Arne ; Lau Börjesson, Joey ; Westermark, Kerstin title: Remarkable developments in our performance date: 2020-10-12 words: 1098 flesch: 65 summary: First of all, the lack of an increase in the submission figure last year was due to a maintenance failure of the submission portal during a 5- month period. For quite a long time we have discussed whether we should join the present trend in scholarly pub- lishing, i.e. terminating the printing of scientific journals. keywords: figure; journal; year cache: ujms-5705.pdf plain text: ujms-5705.txt item: #40 of 550 id: ujms-5706 author: Haghi, Mehrnaz ; Masoudi, Raheleh ; Morteza Najibi, Seyed title: Distinctive alteration in the expression of autophagy genes in Drosophila models of amyloidopathy and tauopathy date: 2020-07-11 words: 7116 flesch: 61 summary: We used Tau R406W transgenic flies as they have been reported to exhibit AD-like phenotypes (52). Bayesian contrast estimation for medians of genes expressions (control–cross) in 5- and 25-day-old flies and different genes and fly types. keywords: ab42; alzheimer; autophagy; cathepsin; day; disease; drosophila; expression; flies; genes; https://doi.org/10.1080/03009734.2020.1785063; levels; r406w; tau; tau r406w; transgenic cache: ujms-5706.pdf plain text: ujms-5706.txt item: #41 of 550 id: ujms-5707 author: Bamberg, Krister ; William-Olsson, Lena ; Johansson, Ulrika ; Arner, Anders ; Hartleib-Geschwindner, Judith ; Sällström, Johan title: Electrolyte handling in the isolated perfused rat kidney: demonstration of vasopressin V2-receptor-dependent calcium reabsorption date: 2020-08-19 words: 5577 flesch: 48 summary: The study thereby provides evidence for a stimulatory role of V2R in renal calcium reabsorption. Results: Kidneys subjected to V2R stimulation using desmopressin (DDAVP) displayed stable osmolality and calcium reabsorption throughout the experiment, whereas kidneys not administered DDAVP exhibited a simultaneous fall in urine osmolality and calcium reabsorption. keywords: bsa; calcium; control; ddavp; effects; kidney; osmolality; perfusion; physiol; pressure; reabsorption; renal; sodium; system; urine cache: ujms-5707.pdf plain text: ujms-5707.txt item: #42 of 550 id: ujms-5710 author: Chen, Sai ; Liu, Hanting ; Li, Tie ; Huang, Rong ; Gui, Rong ; Zhang, Junhua title: Correlation analysis of coagulation dysfunction and liver damage in patients with novel coronavirus pneumonia: a single-center, retrospective, observational study date: 2020-09-29 words: 3290 flesch: 49 summary: A case control study was conducted to analyse the correlation between the occurrence of coagulation dysfunction and liver damage in COVID-19 patients. Several studies have shown that, in addition to coagula- tion dysfunction, COVID-19 patients will have different degrees of liver damage as well. keywords: blood; coagulation; coagulopathy; coronavirus; covid-19; damage; dysfunction; group; hospital; liver; patients cache: ujms-5710.pdf plain text: ujms-5710.txt item: #43 of 550 id: ujms-5711 author: Strang, Peter ; Fürst, Per ; Schultz, Torbjörn title: Excess deaths from COVID-19 correlate with age and socio-economic status. A database study in the Stockholm region date: 2020-10-14 words: 6842 flesch: 58 summary: Because the debate in the media included a great deal of criticism of nursing home care, we also decided to study to what degree nursing home residents dying from other causes were acutely admitted to other services during the last two weeks of life, i.e. in the dying phase. A pos- sible explanation is that the general discussion, where the medical competence of nursing homes was questioned in the media, affected the public’s view on nursing home care in general, with subsequent requirements for referrals to hospitals. keywords: age; care; causes; covid-19; data; deaths; home; march; mosaic; nursing; residents; stockholm; study cache: ujms-5711.pdf plain text: ujms-5711.txt item: #44 of 550 id: ujms-5712 author: Lidström, Anna-Karin ; Sund, Fredrik ; Albinsson, Bo ; Lindbäck, Johan; Westman, Gabriel title: Work at inpatient care units is associated with an increased risk of SARS-CoV-2 infection; a cross-sectional study of 8679 healthcare workers in Sweden date: 2020-07-20 words: 3321 flesch: 53 summary: However, our analyses show that healthcare workers at inpatient care units have a statistically significantly increased risk of infection that cannot be explained by demographic differences or transmission at Covid-19 specific care units only. Evaluation of the unadjusted subgroup prevalence of IgG anti-SARS-CoV-2 seropositive subjects shows higher proportions of IgG positive subjects among male participants and those working in inpatient care units and Covid-19 specific units (Table 1; Figure 2). keywords: care; cov-2; covid-19; healthcare; igg; sars; study; subjects; sweden; units; uppsala cache: ujms-5712.pdf plain text: ujms-5712.txt item: #45 of 550 id: ujms-5713 author: Hugosson, Magnus ; Ekström, Curt title: Prevalence and risk factors for age-related cataract in Sweden date: 2020-08-06 words: 3733 flesch: 62 summary: Identifying modifiable predictors for the development of cataract will make it possible to initiate strategies to delay the need for cataract surgery. Individuals with definite lens opacities in either eye or those who had undergone cataract surgery in one or both eyes were classified as having cataract. keywords: age; cataract; eye; factors; lens; opacities; population; prevalence; risk; study cache: ujms-5713.pdf plain text: ujms-5713.txt item: #46 of 550 id: ujms-5714 author: Caccamisi, Andrea ; Jørgensen, Leif ; Dalianis, Hercules ; Rosenlund, Mats title: Natural language processing and machine learning to enable automatic extraction and classification of patients’ smoking status from electronic medical records date: 2020-07-22 words: 7194 flesch: 56 summary: This confirms that if enough training data are avail- able, a machine-learning classification model generally has the capability of performing better than the analogue rule- based model (35,36). Classifier Feature Model SMO k-NN Freq Unigrams only Attribute selection Cost 1 � – – � – 1751 2 � – – � � 1983 3 � – – – – 1059 4 � – – – � 1467 5 � – � � – 2139 6 � – � � � 2322 7 � – � – – 1627 8 � – � – � 1921 9 – � – � – 1949 10 – � – � � 1990 11 – � – – – 1970 12 – � – – � 1873 13 – � � � – 2182 14 – � � � � 2327 15 – � � – – 2060 16 – � � – � 2073 Table 6. keywords: accuracy; classification; classifier; data; learning; machine; model; sentence; set; smoker; smoking; status; test; text; training; unigrams cache: ujms-5714.pdf plain text: ujms-5714.txt item: #47 of 550 id: ujms-5716 author: Tholander, Bengt ; Koliadi, Anthoula ; Botling, Johan ; Dahlstrand, Hanna ; Von Heideman, Anne ; Ahlström, Håkan ; Öberg, Kjell; Ullenhag, Gustav J. title: Complete response with combined BRAF and MEK inhibition in BRAF mutated advanced low-grade serous ovarian carcinoma date: 2020-10-10 words: 2925 flesch: 54 summary: A few cases with responses on BRAF inhibitor treatment have been reported in ovarian cancer (7). One might assume that all patients with BRAF mutant cancer would benefit from treatment with BRAF inhibitors. keywords: braf; cancer; grade; inhibitor; lgsoc; mek; ovarian; therapy; treatment cache: ujms-5716.pdf plain text: ujms-5716.txt item: #48 of 550 id: ujms-5718 author: Barrueta Tenhunen, Annelie ; Massaro, Fabrizia ; Hansson, Hans Arne ; Feinstein, Ricardo ; Larsson, Anders ; Larsson, Anders ; Perchiazzi, Gaetano title: Does the antisecretory peptide AF-16 reduce lung oedema in experimental ARDS? date: 2019-11-08 words: 6025 flesch: 54 summary: Until the initiation of lung injury the lungs were ventilated with tidal volume (VT) 8 ml/kg, respiratory rate (RR) 30/min, inspiratory/expiratory time (I:E) 1:2, inspired oxygen concen- tration (FIO2) 0.7, and positive end-expiratory pressure (PEEP) 5 cmH2O. An oesophageal catheter (Oesophageal catheter, Erich Jaeger GmbH, H€ochberg, Germany) was positioned in the distal third of the oesophagus, and the correct position was assessed by a modified Baydur procedure by finding less than 10% difference between simultaneous measurement of the oesophageal and the occluded airway pressures during compression of the chest wall (22), in order to ascertain that the oesophageal measurements reflected the pressure changes at the pleural surface. Lung injury was then induced using a two-hit injury model according to an established protocol (24). keywords: af-16; antisecretory; ards; cmh2o; control; evlw; factor; group; injury; lung; oedema; pressure; study; uppsala cache: ujms-5718.pdf plain text: ujms-5718.txt item: #49 of 550 id: ujms-5719 author: Nyberg, Christoffer ; Ronne Engström, Elisabeth ; Hillered, Lars ; Karlsson, Torbjörn title: Daily systemic energy expenditure in the acute phase of aneurysmal subarachnoid hemorrhage date: 2019-12-17 words: 3548 flesch: 57 summary: In order to provide an adequate amount of energy to SAH patients, it would be beneficial to routinely use IC. Daily systemic energy expenditure in the acute phase of aneurysmal subarachnoid hemorrhage ARTICLE Daily systemic energy expenditure in the acute phase of aneurysmal subarachnoid hemorrhage Christoffer Nyberga, Elisabeth Ronne Engstr€oma, Lars Hillereda and Torbj€orn Karlssonb aDepartment of Neuroscience, Section of Neurosurgery, Uppsala University, Uppsala, Sweden; bDepartment of Surgical Sciences, Section of Anesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden ABSTRACT Background: Patients with subarachnoid hemorrhage often have impaired consciousness and cannot regulate nutritional intakes themselves. keywords: energy; equation; measurements; patients; sah; week cache: ujms-5719.pdf plain text: ujms-5719.txt item: #50 of 550 id: ujms-5720 author: Agnarsdóttir, Margrét ; Päären, Helen ; Vassilaki, Ismini title: The impact of standardized care pathway on reporting time for invasive melanoma – results from one pathology department in Sweden date: 2019-10-29 words: 3877 flesch: 46 summary: There was a gradual increase in the number of SCP cases dur- ing the study period, with a corresponding decrease in the num- ber of general priority cases. Materials and methods: Information on reporting time was collected on all samples handled accord- ing to the SCP and on all invasive melanomas diagnosed in 2016–2018 at the Department of Clinical Pathology, Akademiska University Hospital, Uppsala, Sweden. keywords: cases; melanoma; pathology; priority; reporting; scp; time cache: ujms-5720.pdf plain text: ujms-5720.txt item: #51 of 550 id: ujms-5721 author: Cederholm, Jan ; Zethelius, Björn title: SPISE and other fasting indexes of insulin resistance: risks of coronary heart disease or type 2 diabetes. Comparative cross-sectional and longitudinal aspects date: 2019-11-07 words: 7421 flesch: 59 summary: However, comparing the highest quartile (recommended to define insulin resistance) with the lower quartiles, SPISE-IR was the strongest and the only statistically signifi- cant insulin resistance index: HR 1.53 (p ¼ 0.02). 268 J. CEDERHOLM AND B. ZETHELIUS Cross-sectional associations at baseline between clamp M/I-IR and insulin resistance indexes Spearman correlation coefficients between insulin clamp M/I- IR and each fasting insulin resistance index were 0.62 (95% CI 0.58–0.65) for SPISE-IR, 0.60 (0.56–0.65) for QUICKI-IR, 0.60 (0.56–0.64) for Log HOMA-IR, and 0.61 (0.57–0.65) for Rev QUICKI-IR, all p < 0.001 (Table 2). keywords: clamp; diabetes; fasting; glucose; homa; index; indexes; insulin; insulin resistance; quicki; resistance; risk; spise; study; type cache: ujms-5721.pdf plain text: ujms-5721.txt item: #52 of 550 id: ujms-5722 author: Ruzman, Lucija ; Kolic, Ivana ; Radic Nisevic, Jelena ; Ruzic Barsic, Antonija ; Skarpa Prpic, Ingrid ; Prpic, Igor title: A novel VARS2 gene variant in a patient with epileptic encephalopathy date: 2019-10-18 words: 4253 flesch: 62 summary: A novel VARS2 gene variant in a patient with epileptic encephalopathy CASE REPORT A novel VARS2 gene variant in a patient with epileptic encephalopathy Lucija Ruzmana�, Ivana Kolica�, Jelena Radic Nisevica,b, Antonija Ruzic Barsicc, Ingrid Skarpa Prpicd and Igor Prpica,b aChild Neurology and Child Psychiatry Department, Pediatric Clinic, Clinical Hospital Center Rijeka, Rijeka, Croatia; bUniversity of Rijeka, School of Medicine Rijeka, Rijeka, Croatia; cRadiology Department, Thalassoterapia Opatija, Opatija, Croatia; dNeurology Clinic, Clinical Hospital Center Rijeka, Rijeka, Croatia ABSTRACT Background: Mitochondrial disorders are heterogeneous clinical syndromes caused by defective activ- ity in the mitochondrial respiratory chain, resulting in a faulty oxidative phosphorylation system. Laboratory findings revealed an increased concentration of alanine in plasma (537 lmol/L, normal range 100–439 lmol/L) and cere- brospinal fluid (36.1 lmol/L, normal range 19.9–31.3 lmol/L), as well as mildly elevated concentrations of lactate in plasma (2.0–5.4 mmol/L, normal range 0.33–2.0 mmol/L) and cerebro- spinal fluid (3.0 mmol/L, normal range 1.1–2.8 mmol/) indica- tive of mitochondrial disorder, while others were normal. keywords: rijeka; vars2 cache: ujms-5722.pdf plain text: ujms-5722.txt item: #53 of 550 id: ujms-5723 author: Mayahi, Sabah ; Golalipour, Masood ; Yamchi, Ahad ; Deep Jhingan, Gagan ; Shahbazi, Majid title: New insights into the roles of the FOXO3 and P27Kip1 genes in signaling pathways date: 2019-07-11 words: 6248 flesch: 61 summary: Proteomic analysis is generally applied in breast cancer serving two ends, namely the identification of novel molecular markers for breast tumor profiling and determination of the intracellular signaling pathways contributing to the growth of breast cancer cells (8). In a study performed by Xiao-Jing Du et al., the growth of human cancer cells, such as breast cancer cells, was inhibited by high concentra- tions of albumin (16). keywords: breast; cancer; cell; expression; figure; foxo3a; gene; medical; p27kip1; protein; sciences; transfection cache: ujms-5723.pdf plain text: ujms-5723.txt item: #54 of 550 id: ujms-5724 author: Edén, Desirée ; Panagiotou, Grigorios ; Mokhtari, Dariush ; Eriksson, Jan W. ; Åberg, Mikael ; Siegbahn, Agneta title: Adipocytes express tissue factor and FVII and are procoagulant in a TF/FVIIa-dependent manner date: 2019-08-13 words: 8193 flesch: 58 summary: UPSALA JOURNAL OF MEDICAL SCIENCES 167 Abstract Introduction Materials and methods Reagents Human adipocyte isolation 3T3-L1 cell culture, differentiation, and DREAM MDA-MB-231, HCC1937, and KATOIII cell culture siRNA transfection in 3T3-L1 adipocytes mRNA analysis Western blot Coagulation activity assay Lipolysis in human primary adipocyte Lipolysis in 3T3-L1 adipocytes Signaling Glucose uptake in human primary adipocytes Statistics Results TF and FVII are expressed in human adipocytes, and TF can be effectively down-regulated in 3T3-L1 adipocytes Adipocytes are procoagulant in a TF/FVIIa-dependent manner in both human primary adipocytes and 3T3-L1 adipocytes Lipolysis in human primary adipocytes is not affected by FVIIa stimulation Lipolysis in 3T3-L1 adipocytes is not affected by FVIIa stimulation, TF down-regulation, and PAR1 or PAR2 agonists Long-term cytokine treatment results in lipolysis, but combination with FVIIa stimulation does not alter the lipolysis rate Hormone-sensitive lipase (HSL) is phosphorylated by isoproterenol but unaffected by FVIIa stimulation Glucose uptake in human primary adipocytes is not affected by FVIIa stimulation Discussion Acknowledgements Disclosure statement References Conclusion: Human primary adipocytes express active TF and FVII, and the TF/FVIIa complex formed on the adipocyte surface can activate substrate FX. keywords: 3t3; adipocytes; cells; coagulation; factor; figure; fviia; glucose; human; insulin; isoproterenol; l1 adipocytes; lipolysis; signaling; stimulation; tissue cache: ujms-5724.pdf plain text: ujms-5724.txt item: #55 of 550 id: ujms-5731 author: Thorbjørnsen, Knut ; Svensjö, Sverker ; Gidlund, Khatereh Djavani ; Gilgen, Nils-Peter ; Wanhainen, Anders title: Prevalence and natural history of and risk factors for subaneurysmal aorta among 65-year-old men date: 2019-08-28 words: 5653 flesch: 62 summary: AAA ¼ abdominal aortic aneurysm; iAAA ¼ intact abdominal aortic aneurysm. Statin use 31.0% (22.0–41.0) 41.0% (33.0–50.0) 1.55 (0.90–2.66) 0.111 AAA ¼ abdominal aortic aneurysm; SAA ¼ subaneurysmal aorta. keywords: aaa; aneurysm; aortic; men; risk; saa; screening; smoking; study; surg; years cache: ujms-5731.pdf plain text: ujms-5731.txt item: #56 of 550 id: ujms-5735 author: Velders, Matthijs A. ; Calais, Fredrik ; Dahle, Nina ; Fall, Tove ; Hagström, Emil ; Leppert, Jerzy ; Nowak, Christoph ; Tenerz, Åke ; Ärnlöv, Johan ; Hedberg, Pär title: Cathepsin D improves the prediction of undetected diabetes in patients with myocardial infarction date: 2019-08-20 words: 5275 flesch: 47 summary: Reddy S, Amutha A, Rajalakshmi R, Bhaskaran R, Monickaraj F, Rangasamy S, et al. Association of increased levels of MCP-1 and cathepsin-D in young onset type 2 diabetes patients (T2DM-Y) with severity of diabetic retinopathy. Proteomics Measurement of protein biomarkers in plasma was per- formed using the Olink Proseek Multiplex CVDI 96x96 (Olink Bioscience, Uppsala, Sweden) at the Clinical Biomarkers Facility, Science for Life Laboratory, Uppsala University, Uppsala, Sweden, as described previously (10). keywords: biomarkers; cathepsin; clinical; diabetes; dysglycaemia; fpg; glucose; hba1c; infarction; ogtt; patients; risk; sweden; tolerance cache: ujms-5735.pdf plain text: ujms-5735.txt item: #57 of 550 id: ujms-5736 author: Iłżecka, Joanna ; Iłżecki, Marek ; Grabarska, Aneta ; Dave, Shawn ; Feldo, Marcin ; Zubilewicz, Tomasz title: Clusterin as a potential marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy date: 2019-08-28 words: 4963 flesch: 55 summary: Conclusion: Data from our study indicate that serum CLU concentrations are affected after CEA. We hypothesize that serum CLU concentrations may depend on brain ischemia-reperfusion injury follow- ing this surgical procedure. keywords: brain; carotid; cea; clu; clusterin; concentrations; injury; ischemia; patients; reperfusion; serum; study cache: ujms-5736.pdf plain text: ujms-5736.txt item: #58 of 550 id: ujms-5737 author: Talsi, Oskar ; Kiiski Berggren, Ritva ; Johansson, Göran ; Winsö, Ola title: A national survey on routines regarding sedation in Swedish intensive care units date: 2019-05-23 words: 3608 flesch: 62 summary: Methods: A digital survey was sent to the ICUs in Sweden, asking for sedation routines regarding hyp- nosedatives, analgosedatives, protocols, sedation scales, etc. Results: All units used sedation scales, and 88% used the RASS scale; 80% used written guidelines for sedation. keywords: care; choice; dexmedetomidine; icu; intensive; scale; sedation; survey; units; use cache: ujms-5737.pdf plain text: ujms-5737.txt item: #59 of 550 id: ujms-5738 author: Skogsdal, Yvonne ; Fadl, Helena ; Cao, Yang ; Karlsson, Jan ; Tydén, Tanja title: An intervention in contraceptive counseling increased the knowledge about fertility and awareness of preconception health—a randomized controlled trial date: 2019-09-09 words: 8360 flesch: 63 summary: An intervention in contraceptive counseling increased the knowledge about fertility and awareness of preconception health—a randomized controlled trial ARTICLE An intervention in contraceptive counseling increased the knowledge about fertility and awareness of preconception health—a randomized controlled trial Yvonne Skogsdala , Helena Fadlb , Yang Caoc , Jan Karlssond and Tanja Tyd�ene aMaternal Health Care Unit, Faculty of Medicine and Health, €Orebro University, €Orebro, Sweden; bDepartment of Obstetrics and Gynecology, Faculty of Medicine and Health, €Orebro University, €Orebro, Sweden; cClinical Epidemiology and Biostatistics, School of Medical Sciences, €Orebro University, €Orebro, Sweden; dUniversity Health Care Research Center, Faculty of Medicine and Health, €Orebro University, €Orebro, Sweden; eDepartment of Women’s and Children’s Health, Akademiska Sjukhuset, Uppsala, Sweden ABSTRACT Background: Reproductive life plan counseling (RLPC) is a tool to encourage women and men to reflect upon their reproduction, to avoid unintended pregnancies and negative health behavior that can threaten reproduction. Baba S, Wikstrom AK, Stephansson O, Cnattingius S. Changes in snuff and smoking habits in Swedish pregnant women and risk for small for gestational age births. keywords: acid; age; contraceptive; counseling; fertility; folic; health; intervention; knowledge; preconception; pregnancy; reproductive; study; women cache: ujms-5738.pdf plain text: ujms-5738.txt item: #60 of 550 id: ujms-5740 author: Team, The UJMS Editorial title: Membership announcement date: 2019-09-17 words: 287 flesch: 47 summary: He was appointed director of the Uppsala branch of Ludwig Cancer Research 1986 and professor in molecular cell biology at the medical faculty of Uppsala University 1992. Gunne Hall, University Hospital entrance 10, Uppsala HOUR: 17:30 Professor Heldin is a molecular biologist and medical researcher. keywords: professor; uppsala cache: ujms-5740.pdf plain text: ujms-5740.txt item: #61 of 550 id: ujms-5741 author: Pettersson, Ulf title: Encounters with adenovirus date: 2019-05-29 words: 10384 flesch: 61 summary: Ad gene mapping was revolution- ized when RNA-loop technology was introduced for mapping RNA transcripts. A study of non-structural Ad proteins unraveled the primary structures of the proteins predicted to be encoded by the viral genome. keywords: ad2; adenovirus; cell; changes; cycle; dna; expression; genes; genome; hpi; human; infection; level; pathway; pettersson; protein; replication; rna; studies; time; type; virology; zhao cache: ujms-5741.pdf plain text: ujms-5741.txt item: #62 of 550 id: ujms-5742 author: Lönnberg, Lena; Ekblom-Bak, Elin ; Damberg, Mattias title: Improved unhealthy lifestyle habits in patients with high cardiovascular risk: results from a structured lifestyle programme in primary care date: 2019-05-07 words: 11725 flesch: 71 summary: Improved unhealthy lifestyle habits in patients with high cardiovascular risk: results from a structured lifestyle programme in primary care ARTICLE Improved unhealthy lifestyle habits in patients with high cardiovascular risk: results from a structured lifestyle programme in primary care Lena L€onnberga,b , Elin Ekblom-Bakc and Mattias Damberga,b aCenter for Clinical Research, County of V€astmanland, Uppsala University, V€asterås, Sweden; bDepartment of Public Health and Caring Sciences, Family Medicine and Preventive Medicine, Uppsala University, Uppsala, Sweden; cThe Swedish School of Sports and Health Sciences, Stockholm, Sweden ABSTRACT Background. The aim of the present study was two-fold: (1) to describe a novel lifestyle intervention programme in primary care; and (2) to evaluate change in unhealthy lifestyle habits over 1 year in men and women with high cardiovascular risk who participated in the lifestyle intervention programme. keywords: d m; habits; lifestyle; n .s cache: ujms-5742.pdf plain text: ujms-5742.txt item: #63 of 550 id: ujms-5743 author: Lundberg, Josefine ; Berglund, David ; Molin, Daniel ; Kinch, Amelie title: Intratumoral expression of FoxP3-positive regulatory T-cells in T-cell lymphoma: no correlation with survival date: 2020-03-11 words: 4475 flesch: 56 summary: T regulatory cells show strong prog- nostic significance in colorectal cancer. Targeting regulatory T cells in tumors. keywords: cells; expression; foxp3þ; lymphoma; mm2; survival; tcl; tregs cache: ujms-5743.pdf plain text: ujms-5743.txt item: #64 of 550 id: ujms-5744 author: Milutinović, Bojana ; Goč, Sanja ; Mitić, Ninoslav ; Kosanović, Maja ; Janković, Miroslava title: Surface glycans contribute to differences between seminal prostasomes from normozoospermic and oligozoospermic men date: 2019-04-08 words: 5214 flesch: 49 summary: Surface glycans contribute to differences between seminal prostasomes from normozoospermic and oligozoospermic men ARTICLE Surface glycans contribute to differences between seminal prostasomes from normozoospermic and oligozoospermic men Bojana Milutinovi�c, Sanja Go�c , Ninoslav Miti�c , Maja Kosanovi�c and Miroslava Jankovi�c University of Belgrade, Institute for the Application of Nuclear Energy, INEP, Zemun, Serbia ABSTRACT Background: Extracellular vesicles (EVs), released from the plasma membrane or intracellular compartments, have a specific composition related to their parent cells, but they can, additionally, be modified by the extracellular environment. In this study, seminal prostasomes, i.e. EVs from seminal plasma (SP) of normo- and oligozoospermic men, were analyzed in order to detect possible changes in their surface glycans under altered physiological conditions. keywords: cona; evs; extracellular; glycans; human; men; min; normozoospermic; oligozoospermic; prostasomes; protein; surface; vesicles cache: ujms-5744.pdf plain text: ujms-5744.txt item: #65 of 550 id: ujms-5745 author: Sone, Miyuki ; Arai, Yasuaki ; Sugawara, Shunsuke ; Kubo, Takatoshi ; Itou, Chihiro ; Hasegawa, Tetsuya ; Umakoshi, Noriyuki ; Yamamoto, Noboru ; Sunami, Kumiko ; Hiraoka, Nobuyoshi ; Kubo, Takashi title: Feasibility of genomic profiling with next-generation sequencing using specimens obtained by image-guided percutaneous needle biopsy date: 2019-06-09 words: 4365 flesch: 51 summary: The purpose of this study was to evaluate the feasibility of genomic analysis using NGS with specimens obtained by image-guided percutaneous needle biopsy with 18-G needles. The success rate of genomic analysis was 79.2% (38/48). keywords: analysis; biopsy; cancer; dna; genomic; needle; ngs; patients; profiling; rate; specimens; study; tumor cache: ujms-5745.pdf plain text: ujms-5745.txt item: #66 of 550 id: ujms-5746 author: Wentzel, Parri ; Eriksson, Ulf J. ; Herrera, Emilio title: High-fat diet in pregnant rats and adverse fetal outcome date: 2019-05-07 words: 8860 flesch: 68 summary: Plasma/serum components The glucose concentration was higher in HFD rats than in CD rats, whereas the insulin concentration was similar (Table 1). At day 20 of pregnancy, the sum of SFA was lower in HFD rats than in CD rats. keywords: acid; cd rats; concentrations; day; diet; fat; fatty; gestational; hfd; hfd rats; maternal; n-3; n-6; plasma; pregnancy; rats; serum; sum; tissue cache: ujms-5746.pdf plain text: ujms-5746.txt item: #67 of 550 id: ujms-5747 author: Öberg, Mariella ; Skalkidou, Alkistis ; Heimer, Gun title: Experiences of sexual violence among women seeking services at a family planning unit in Sweden date: 2019-05-13 words: 4305 flesch: 50 summary: The primary aim of this study was to assess the prevalence and correlates of sexual violence experiences among women seek- ing care at a family planning unit in Sweden. The primary aim of the current study was to assess the prevalence and correlates of sexual violence experiences among women seeking care at a family planning unit in Sweden. keywords: experiences; health; non; partner; prevalence; sexual; study; violence; women cache: ujms-5747.pdf plain text: ujms-5747.txt item: #68 of 550 id: ujms-5748 author: Henoch, Ingela ; Strang, Peter ; Löfdahl, Claes-Göran ; Ekberg-Jansson, Ann title: Equal palliative care for patients with COPD? A nationwide register study date: 2019-04-23 words: 5879 flesch: 59 summary: In a review, HRQoL in palliative care patients was related to symptom burden and health care issues, but also to cog- nitive, emotional, social, and spiritual aspects, and to issues about personal autonomy, and preparedness (15). Clinical characteristics related to stage of COPD according to the GOLD stages (1), number of exacer- bations the last 12 months, number of hospitalizations due to COPD in the last 12 months, FEV1% of predicted value, comorbidities, and exercise capacity, measured by the num- ber of days per week that the patient had been physically active. keywords: care; copd; death; disease; life; nursing; palliative; patients; spc; specialized; symptom; variables cache: ujms-5748.pdf plain text: ujms-5748.txt item: #69 of 550 id: ujms-5749 author: Team, The UJMS Editorial title: Corrigendum date: 2019-06-09 words: 94 flesch: 23 summary: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Published by Informa UK Limited, trading as Taylor & Francis Group. keywords: corrigendum cache: ujms-5749.pdf plain text: ujms-5749.txt item: #70 of 550 id: ujms-5756 author: Wallentin, Lars ; Lindahl, Bertil title: Uppsala Clinical Research Center—development of a platform to promote national and international clinical science date: 2018-12-04 words: 4622 flesch: 41 summary: Clinical research projects were often limited to either being a minor contributor in industry-related international mega-trials or performing local, underpowered, underfunded research projects with small chances to produce results with international impact. ARTICLE HISTORY Received 2 October 2018 Revised 22 October 2018 Accepted 22 October 2018 KEY WORDS Biobank; biomarkers; clinical research; clinical trials; genetics; health economy; quality develop- ment; registries Introduction Uppsala Clinical Research Center (UCR) is a non-profit organiza- tion that supports research and quality development in health care in Sweden and internationally. keywords: care; clinical; development; group; health; quality; registry; research; services; trials; ucr; uppsala cache: ujms-5756.pdf plain text: ujms-5756.txt item: #71 of 550 id: ujms-5757 author: Beskow, Anna title: Uppsala Biobank—the development of a biobank organization in a local, regional, and national setting date: 2019-02-01 words: 2189 flesch: 55 summary: A competence center for biobank matters Uppsala Biobank activities include information and education of researchers, staff, and students. Uppsala Biobank started on 1 September 2008 and had four aims: 1) to administrate Uppsala Biobank; 2) to build a stable and long-term organization; 3) to be a competence center for biobank matters; 4) and to build an infrastructure for research. Administration of Uppsala Biobank The first decision of the local Biobank council was that there would be only one biobank in Uppsala, which meant trans- forming all previous 138 biobanks into sample collections. keywords: biobank; health; research; samples; uppsala cache: ujms-5757.pdf plain text: ujms-5757.txt item: #72 of 550 id: ujms-5758 author: Lysholm, Jack ; Lindahl, Bertil title: Strong development of research based on national quality registries in Sweden date: 2018-10-01 words: 1830 flesch: 55 summary: Quality registries that have applied for and been granted national funding are referred to as national quality registries (NQRs). Strong development of research based on national quality registries in Sweden ARTICLE Strong development of research based on national quality registries in Sweden Jack Lysholma and Bertil Lindahlb aDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; bDepartment of Medical Sciences and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden ABSTRACT The aim of the present paper is to describe how the use of national quality registries (NQRs) for research has evolved over the past decade in Sweden. keywords: nqrs; quality; research; sweden; swedish cache: ujms-5758.pdf plain text: ujms-5758.txt item: #73 of 550 id: ujms-5759 author: Baron, Tomasz ; Beskow, Anna ; James, Stefan ; Lindahl, Bertil title: Biobank linked to SWEDEHEART quality registry—routine blood sample collection opens new opportunities for cardiovascular research date: 2018-09-25 words: 2284 flesch: 44 summary: Biobank linked to SWEDEHEART quality registry—routine blood sample collection opens new opportunities for cardiovascular research ARTICLE Biobank linked to SWEDEHEART quality registry—routine blood sample collection opens new opportunities for cardiovascular research Tomasz Barona,b, Anna Beskowb,c, Stefan Jamesa,b and Bertil Lindahla,b aDepartment of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; bUppsala Clinical Research Center, Uppsala, Sweden; cUppsala Biobank, Uppsala, Sweden ABSTRACT High-quality biobanking within routine health services, through the use of existing health-care practi- ces and infrastructure, with respect to safety and integrity of patients in line with the Swedish Biobank Act, enables large-scale collection of biological material at reasonable costs. Currently a lot of work is being done and has been done to transform many small biobanks into sample collections in a larger biobank organization, for example, Uppsala Biobank in Sweden. keywords: biobank; care; registry; research; samples; swedeheart; uppsala cache: ujms-5759.pdf plain text: ujms-5759.txt item: #74 of 550 id: ujms-5760 author: Lind, Lars title: Population-based cardiovascular cohort studies in Uppsala date: 2018-10-03 words: 3748 flesch: 54 summary: First, studies with a limited number of subjects (some hundreds to a cou- ple of thousands) that have been extensively phenotyped; ULSAM, PIVUS, and POEM are examples of such studies. In conclusion, several CVD cohort studies with different characteristics exist in Uppsala which makes it possible to explore hypotheses demanding both a large number of par- ticipants, as well as a deep phenotyping of markers of sub- clinical CVD and long follow-up periods. keywords: atherosclerosis; cardiovascular; cvd; lind; risk; studies; study; uppsala; years cache: ujms-5760.pdf plain text: ujms-5760.txt item: #75 of 550 id: ujms-5761 author: Sundström, Johan ; Björkelund, Cecilia ; Giedraitis, Vilmantas ; Hansson, Per-Olof ; Högman, Marieann ; Janson, Christer ; Koupil, Ilona ; Kristenson, Margareta ; Trolle Lagerros, Ylva ; Leppert, Jerzy ; Lind, Lars ; Lissner, Lauren ; Johansson, Ingegerd ; Ludvigsson, Jonas F. ; Nilsson, Peter M. ; Olsson, Håkan ; Pedersen, Nancy L. ; Rosenblad, Andreas ; Rosengren, Annika ; Sandin, Sven ; Snäckerström, Tomas ; Stenbeck, Magnus ; Söderberg, Stefan ; Weiderpass, Elisabete ; Wanhainen, Anders ; Wennberg, Patrik ; Fortier, Isabel ; Heller, Susanne ; Storgärds, Maria ; Svennblad, Bodil title: Rationale for a Swedish cohort consortium date: 2019-01-08 words: 6319 flesch: 42 summary: Requirements for cohort data were stated in a research proposal, with very few inclusion (data on systolic and diastolic blood pressure and smoking status) and exclu- sion (previous SAH) criteria. The Maelstrom Research offers guidelines (23) and a suite of open source software (24) (Opal, Onyx, Mica, and Agate) to support management of cohort data. keywords: access; analysis; cohorts; cohorts.se; consortium; data; harmonization; health; management; medicine; research; study; sweden; swedish; time; university; use cache: ujms-5761.pdf plain text: ujms-5761.txt item: #76 of 550 id: ujms-5762 author: Snäckerström, Tomas ; Johansen, Christian title: De-identified linkage of data across separate registers: a proposal for improved protection of personal information in registry-based clinical research date: 2019-02-07 words: 3411 flesch: 44 summary: 2. Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free move- ment of such data, and repealing Directive 95/46/EC (General Data Protection Regulation); 2016. Register A may not disclose personal data to register B and vice versa. keywords: data; information; issuing; key; registers; service cache: ujms-5762.pdf plain text: ujms-5762.txt item: #77 of 550 id: ujms-5763 author: Nyberg, Karl ; Hedman, Peter title: Swedish guidelines for registry-based randomized clinical trials date: 2019-02-06 words: 2714 flesch: 46 summary: The CEC group can then handle the collection of data and adjudication in their nor- mal workflow. Registry-based randomized clinical trial framework Uppsala Clinical Research Center (UCR) has developed a framework for registry clinical trials as an initiative to stand- ardize and facilitate implementation of clinical trials in registries. Clinical trial data model At the heart of the RCT is the clinical trial data model. keywords: clinical; data; framework; model; registry; study; trial cache: ujms-5763.pdf plain text: ujms-5763.txt item: #78 of 550 id: ujms-5764 author: Gedeborg, Rolf ; Cline, Charles ; Zethelius, Björn ; Salmonson, Tomas title: Pragmatic clinical trials in the context of regulation of medicines date: 2018-09-25 words: 4954 flesch: 46 summary: ARTICLE HISTORY Received 17 June 2018 Revised 1 August 2018 Accepted 13 August 2018 KEYWORDS Drug approval; government regulation; methods; pharmaceutical prepara- tions; pragmatic clinical trial What is a pragmatic study? Pragmatic clinical trials embedded in healthcare systems: generalizable lessons from the NIH Collaboratory. keywords: agency; data; effect; medicines; patients; population; pragmatic; results; studies; study; target; trials cache: ujms-5764.pdf plain text: ujms-5764.txt item: #79 of 550 id: ujms-5765 author: Held, Claes title: When do we need clinical endpoint adjudication in clinical trials? date: 2018-11-14 words: 2639 flesch: 45 summary: When do we need clinical endpoint adjudication in clinical trials? When do we need clinical endpoint adjudication in clinical trials? Claes Held Uppsala Clinical Research Center, Department of Medical Sciences, Cardiology, Uppsala, Sweden ABSTRACT Clinical endpoint adjudication (CEA) is a standardized process for assessment of safety and efficacy of pharmacologic or device therapies in clinical trials. keywords: adjudication; cea; definitions; endpoint; events; process; registries; trials cache: ujms-5765.pdf plain text: ujms-5765.txt item: #80 of 550 id: ujms-5766 author: Cars, Thomas ; Lindhagen, Lars ; Sundström, Johan title: A framework for monitoring of new drugs in Sweden date: 2019-01-28 words: 2993 flesch: 44 summary: Proposal for a framework for continuous post- marketing monitoring of new drugs in Sweden We have developed a generic sequential cohort model for real-time head-to-head (drug A versus drug B) comparisons of new drugs when used in routine care. This development parallels a trend towards more use of adaptive licensing of new drugs (3), with healthcare authorities and regulators relying increasingly on observational data for evaluation of drug effectiveness and safety (4–6). keywords: data; drug; effectiveness; framework; healthcare; monitoring; observational; safety; sweden cache: ujms-5766.pdf plain text: ujms-5766.txt item: #81 of 550 id: ujms-5767 author: Sundström, Johan ; Lind, Lars ; Nowrouzi, Shamim ; Lytsy, Per ; Marttala, Kerstin ; Ekman, Inger ; Öhagen, Patrik ; Östlund, Ollie title: The Precision HYpertenSIon Care (PHYSIC) study: a double-blind, randomized, repeated cross-over study date: 2018-09-28 words: 6364 flesch: 49 summary: To investigate patient treatment preferences when pre- sented with: i) their individual ratings for each drug class; ii) a combination of their individual ratings and blood pressure effect of each drug class. To investigate associations of DNA genomic variation, DNA methylation, RNA, proteins, and metabolites with blood pressure effects and self-reported symptoms and quality of life. keywords: blood; blood pressure; drug; effects; hypertension; individual; patient; period; person; pressure; study; treatment; trial; variation; visit cache: ujms-5767.pdf plain text: ujms-5767.txt item: #82 of 550 id: ujms-5768 author: Åkerblom, Axel ; Oldgren, Jonas ; Latva-Rasku, Aino ; Johansson, Lars ; Lisovskaja, Vera ; Karlsson, Cecilia ; Oscarsson, Jan ; Nuutila, Pirjo title: Effects of DAPAgliflozin on CARDiac substrate uptake, myocardial efficiency, and myocardial contractile work in type 2 diabetes patients—a description of the DAPACARD study date: 2019-01-08 words: 5407 flesch: 53 summary: The efficacy data will be collected at the randomization (visit 2; baseline) and end of treatment visit (visit 4, which takes place after 6 weeks on study drug). The primary efficacy endpoint is change in global longitudinal strain of the left ventricle (GLSLV) measured with magnetic resonance imaging (MRI) between baseline (pre-treatment) and end of study (on-treatment). keywords: dapagliflozin; diabetes; efficiency; heart; mri; myocardial; patients; pet; study; treatment; type; visit; work cache: ujms-5768.pdf plain text: ujms-5768.txt item: #83 of 550 id: ujms-5770 author: Batra, Gorav ; Ahlsson, Anders ; Lindahl, Bertil ; Lindhagen, Lars ; Wickbom, Anders ; Oldgren, Jonas title: Atrial fibrillation in patients undergoing coronary artery surgery is associated with adverse outcome date: 2018-09-28 words: 5670 flesch: 49 summary: Patients with history of AF prior to surgery (preoperative AF) and patients without history of AF but with AF episodes post-sur- gery (postoperative AF) were compared to patients with no AF using adjusted Cox regression models. Among 9,107 identified patients, 8.1% (n ¼ 737) had preoperative AF, and 25.1% (n ¼ 2,290) had postoperative AF. keywords: 0.001; atrial; cabg; fibrillation; heart; mortality; patients; postoperative; risk; stroke; study; surgery cache: ujms-5770.pdf plain text: ujms-5770.txt item: #84 of 550 id: ujms-5771 author: Berglund, Lars ; Risérus, Ulf ; Hambraeus, Kristina title: Repeated measures of body mass index and waist circumference in the assessment of mortality risk in patients with myocardial infarction date: 2018-09-26 words: 3883 flesch: 58 summary: Kaplan–Meier curves showed that the group with low BMI and high WC had the highest mortality, and the group with high BMI and low WC had the lowest mortality (Figure 2). Kaplan–Meier survival estimates (from one year after hospital discharge) by anthropometric groups: Low-BMI, Low-WC ¼ BMI<25 kg/m2, WC<102 (male)/88 (female) cm; Low-BMI, High-WC ¼ BMI<25 kg/m2, WC�102/88 cm; High-BMI, Low-WC ¼ BMI�25 kg/m2, WC<102/88 cm; High-BMI, High-WC ¼ BMI�25 kg/m2, WC�102/88 cm. keywords: bmi; discharge; hospital; mortality; obesity; patients; year cache: ujms-5771.pdf plain text: ujms-5771.txt item: #85 of 550 id: ujms-5772 author: Andersson, Arne ; Lau Börjesson, Joey title: A new contribution to research metrics date: 2018-12-04 words: 1625 flesch: 64 summary: At present, in mid-October, the value for UJMS is above 1.60, suggesting a considerable increase compared with last year. Actually, last year we had to report an ‘all-time low’ with only 175 submitted papers. keywords: figure; impact; med; year cache: ujms-5772.pdf plain text: ujms-5772.txt item: #86 of 550 id: ujms-5773 author: Ekselius, Lisa title: Personality disorder: a disease in disguise date: 2018-12-12 words: 9998 flesch: 49 summary: 204 L. EKSELIUS Abstract Introduction A historic perspective of aberrant personalities Modern concepts of personality disorder and personality Classification of personality disorders General description of personality disorders in ICD-11 Dimensions of personality disorders in ICD-11 Negative affectivity in personality disorder Detachment in personality disorder Dissocial or antisocial personality disorder Disinhibition in personality disorder Anankastia in personality disorder Borderline personality disorder Prevalence and longitudinal perspective Diagnosis, differential diagnosis, and psychiatric comorbidity Personality disorders and health Aspects on handling and treatment Conclusion Disclosure statement Note on the contributor References General description of personality disorders in ICD-11 The new ICD-11 classification system, which was released by WHO in June 2018 (42), means a radical change in the classifi- cation of PDs and will impact all aspects of health care, as well as influence the way PDs are seen (43). keywords: borderline; care; characteristics; classification; diagnosis; disorder; functioning; health; icd-11; life; patients; pds; personality; personality disorder; problems; psychiatry; relationships; self; studies; study; time; traits; treatment cache: ujms-5773.pdf plain text: ujms-5773.txt item: #87 of 550 id: ujms-5775 author: Ullenhag, Gustav title: Cancer treatment of today in view of the Nobel Prize date: 2018-12-11 words: 1929 flesch: 51 summary: Unconjugated antibodies can kill cancer cells in several ways. Furthermore, antibodies having bound to cancer cells can activate the complement system via the classical pathway. keywords: antibodies; cancer; cells; patients; treatment; tumour cache: ujms-5775.pdf plain text: ujms-5775.txt item: #88 of 550 id: ujms-5784 author: Al-Mashhadi, Ammar ; Häggman, Michael ; Läckgren, Göran ; Ladjevardi, Sam ; Nevéus, Tryggve ; Stenberg, Arne ; Persson, A. Erik G. ; Carlström, Mattias title: Changes of arterial pressure following relief of obstruction in adults with hydronephrosis date: 2018-10-08 words: 6567 flesch: 48 summary: Changes of arterial pressure following relief of obstruction in adults with hydronephrosis ARTICLE Changes of arterial pressure following relief of obstruction in adults with hydronephrosis Ammar Al-Mashhadia , Michael H€aggmanb, G€oran L€ackgrena, Sam Ladjevardib, Tryggve Nev�eusc , Arne Stenberga, A. Erik G. Perssond and Mattias Carlstr€ome aPediatric Surgery Section, Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden; bDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden; cPediatric Nephrology Unit, Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden; dDepartment Medical Cell Biology, Uppsala University, Uppsala, Sweden; eDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden ABSTRACT Background: As much as 20% of all cases of hypertension are associated with kidney malfunctions. This retrospective cohort study aimed to investigate: (1) the proposed link between hydronephrosis, due to UPJ obstruction, and elevated arterial pressure in adults; and (2) if elevated blood pressure in patients with hydronephrosis might be another indication for surgery. keywords: arterial; blood; hydronephrosis; hypertension; lap; obstruction; patients; post; pressure; pyeloplasty; relief cache: ujms-5784.pdf plain text: ujms-5784.txt item: #89 of 550 id: ujms-5785 author: Halldorsdottir, Sandra ; Dahlstrand, Hanna ; Stålberg, Karin title: Gynecologists are afraid of prescribing hormone replacement to endometrial/ ovarian cancer survivors despite national guidelines—a survey in Sweden date: 2018-12-10 words: 4504 flesch: 50 summary: Estrogen replacement therapy in endometrial cancer patients: a matched control study. Endometrial cancer is the most common gynecological malignancy in Sweden, and its incidence has increased over the last decades from 18.5/100,000 persons/year in 1970 to 28.9/100,000 persons/year in 2014 (5). keywords: cancer; ert; gynecologic; gynecologists; hrt; oncologists; ovarian; risk; survey; women cache: ujms-5785.pdf plain text: ujms-5785.txt item: #90 of 550 id: ujms-5835 author: Ek, Pia; Ek, Bo; Zetterqvist, Örjan title: Phosphohistidine phosphatase 1 (PHPT1) also dephosphorylates phospholysine of chemically phosphorylated histone H1 and polylysine date: 2015-01-09 words: 6076 flesch: 41 summary: Dephosphorylation by PHPT1 of chemically phosphorylated histone H1 All preparations of phosphorylated histone H1 could be dephosphorylated by PHPT1. In the absence of PHPT1, phosphorylated histone H1 was stable under the conditions used, i.e. the mean remaining phos- phohistone H1 for seven separate experiments at 0, 5, and 10 min was 101% ± 2%. keywords: acid; histone; histone h1; kda; mol; peptides; phosphatase; phosphohistidine; phospholysine; phosphoramidate; phosphorylation; phpt1; polylysine; protein; residues cache: ujms-5835.pdf plain text: ujms-5835.txt item: #91 of 550 id: ujms-5839 author: Anvari, Ebrahim; Wang, Xuan; Sandler, Stellan; Welsh, Nils title: The H1-receptor antagonist cetirizine ameliorates high-fat diet-induced glucose intolerance in male C57BL/6 mice, but not diabetes outcome in female non-obese diabetic (NOD) mice date: 2014-10-07 words: 4765 flesch: 41 summary: The non-fasting blood glucose levels of HFD mice were higher than those of ND mice after 7 weeks of diet (Figure 3). Therefore, the aim of this study was to determine whether cetirizine affects diabetes in NOD mice, a model for human type 1 diabetes, and glucose intolerance in high-fat diet C57BL/6 mice, a model for human glucose intolerance. Methods. keywords: blood; cell; cetirizine; diabetes; diet; fat; glucose; hfd; mice; min; nod; receptor; weeks cache: ujms-5839.pdf plain text: ujms-5839.txt item: #92 of 550 id: ujms-5840 author: Zhao, Pan; Liu, Wei-wei; Li, Jin-feng; Wang, Chun-ya; Wang, Hao; Xu, Jun; Wang, Ruifang; Yang, Hao-zhen; Jin, Cheng; Wei, Zhen-man title: Predictors of liver failure in primary biliary cirrhosis date: 2014-11-28 words: 2968 flesch: 42 summary: Predictors of liver failure in primary biliary cirrhosis Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=iups20 Upsala Journal of Medical Sciences ISSN: 0300-9734 (Print) 2000-1967 (Online) Journal homepage: https://www.tandfonline.com/loi/iups20 Predictors of liver failure in primary biliary cirrhosis Pan Zhao, Wei-wei Liu, Jin-feng Li, Chun-ya Wang, Hao Wang, Jun Xu, Rui- fang Wang, Hao-zhen Yang, Cheng Jin & Zhen-man Wei To cite this article: Pan Zhao, Wei-wei Liu, Jin-feng Li, Chun-ya Wang, Hao Wang, Jun Xu, Rui-fang Wang, Hao-zhen Yang, Cheng Jin & Zhen-man Wei (2015) Predictors of liver failure in primary biliary cirrhosis, Upsala Journal of Medical Sciences, 120:1, 47-51, DOI: 10.3109/03009734.2014.985763 To link to this article: https://doi.org/10.3109/03009734.2014.985763 © Informa Healthcare Published online: 28 Nov 2014. Submit your article to this journal Article views: 553 View related articles View Crossmark data Citing articles: 3 View citing articles https://www.tandfonline.com/action/journalInformation?journalCode=iups20 https://www.tandfonline.com/loi/iups20 https://www.tandfonline.com/action/showCitFormats?doi=10.3109/03009734.2014.985763 https://doi.org/10.3109/03009734.2014.985763 https://www.tandfonline.com/action/authorSubmission?journalCode=iups20&show=instructions https://www.tandfonline.com/action/authorSubmission?journalCode=iups20&show=instructions https://www.tandfonline.com/doi/mlt/10.3109/03009734.2014.985763 https://www.tandfonline.com/doi/mlt/10.3109/03009734.2014.985763 http://crossmark.crossref.org/dialog/?doi=10.3109/03009734.2014.985763&domain=pdf&date_stamp=2014-11-28 http://crossmark.crossref.org/dialog/?doi=10.3109/03009734.2014.985763&domain=pdf&date_stamp=2014-11-28 https://www.tandfonline.com/doi/citedby/10.3109/03009734.2014.985763#tabModule https://www.tandfonline.com/doi/citedby/10.3109/03009734.2014.985763#tabModule Upsala Journal of Medical Sciences. 2015; 120: 47–51 ORIGINAL ARTICLE Predictors of liver failure in primary biliary cirrhosis PAN ZHAO1,8, WEI-WEI LIU2, JIN-FENG LI3, CHUN-YA WANG4, HAO WANG5, JUN XU6, RUI-FANG WANG7, HAO-ZHEN YANG8, CHENG JIN1 & ZHEN-MAN WEI1 1Clinical Trial Center, Beijing 302 keywords: ana; beijing; cirrhosis; failure; hospital; liver; mmol; patients; pbc; total; wei cache: ujms-5840.pdf plain text: ujms-5840.txt item: #93 of 550 id: ujms-5841 author: Emtner, Margareta; Hallin, Runa; Arnardottir, Ragnheiður Harpa; Janson, Christer title: Effect of physical training on fat-free mass in patients with chronic obstructive pulmonary disease (COPD) date: 2020-11-28 words: 4892 flesch: 43 summary: Effectiveness of pulmo- nary rehabilitation in exercise capacity and quality of life in chronic obstructive pulmonary disease patients with and with- out global fat-free mass depletion. Physical training of COPD patients has good effect on exercise tolerance and quality of life. keywords: change; chronic; copd; disease; dyspnoea; exercise; fat; ffm; ffmi; mass; patients; pulmonary; respir; training cache: ujms-5841.pdf plain text: ujms-5841.txt item: #94 of 550 id: ujms-5842 author: Ronne-Engström, Elisabeth; Popek, Edith title: Symptomatic colloid cysts in the third ventricle of monozygotic twins date: 2014-12-10 words: 2765 flesch: 46 summary: Microsurgical treatment of third ventricular colloid cysts by interhemispheric far lateral transcallosal approach–experience of 134 patients. Symptomatic colloid cysts in the third ventricle of monozygotic twins, Upsala Journal of Medical Sciences, 120:1, 59-62, DOI: 10.3109/03009734.2014.988309 To link to this article: https://doi.org/10.3109/03009734.2014.988309 © Informa Healthcare Published online: 10 Dec 2014. Submit your article to this journal Article views: 436 View related articles View Crossmark data Citing articles: 2 View citing articles https://www.tandfonline.com/action/journalInformation?journalCode=iups20 https://www.tandfonline.com/loi/iups20 https://www.tandfonline.com/action/showCitFormats?doi=10.3109/03009734.2014.988309 https://doi.org/10.3109/03009734.2014.988309 https://www.tandfonline.com/action/authorSubmission?journalCode=iups20&show=instructions https://www.tandfonline.com/action/authorSubmission?journalCode=iups20&show=instructions https://www.tandfonline.com/doi/mlt/10.3109/03009734.2014.988309 https://www.tandfonline.com/doi/mlt/10.3109/03009734.2014.988309 http://crossmark.crossref.org/dialog/?doi=10.3109/03009734.2014.988309&domain=pdf&date_stamp=2014-12-10 http://crossmark.crossref.org/dialog/?doi=10.3109/03009734.2014.988309&domain=pdf&date_stamp=2014-12-10 https://www.tandfonline.com/doi/citedby/10.3109/03009734.2014.988309#tabModule https://www.tandfonline.com/doi/citedby/10.3109/03009734.2014.988309#tabModule Upsala Journal of Medical Sciences. 2015; 120: 59–62 CASE REPORT FROM UPPSALA UNIVERSITY HOSPITAL Symptomatic colloid cysts in the third ventricle of monozygotic twins ELISABETH RONNE-ENGSTRÖM1 & EDITH POPEK2 1Department of Neuroscience, Section of Neurosurgery, Uppsala University, Uppsala, Sweden, and 2Department of Neurology, Örebro University Hospital, Örebro, Sweden Abstract In this case report we describe colloid cysts in the third ventricles of monozygotic twin sisters. keywords: case; colloid; cysts; familial; monozygotic; report; sister; twin; ventricle cache: ujms-5842.pdf plain text: ujms-5842.txt item: #95 of 550 id: ujms-5843 author: Karlsson, Torbjörn title: Progress and Milestones in Scientific Communication – a 150 years perspective date: 2015-04-14 words: 1035 flesch: 51 summary: Reading the journal through the years means finding many interesting thoughts but also some that we do not agree with Correspondence: Torbjörn Karlsson, Upsala Medical Society, Uppsala, Sweden. Will we still read journals printed on paper in the years to come? keywords: journal; medical; years cache: ujms-5843.pdf plain text: ujms-5843.txt item: #96 of 550 id: ujms-5844 author: Lindberg, Bo S. title: Proceedings of the Upsala Medical Society: How it all started 150 years ago date: 2015-04-27 words: 4818 flesch: 58 summary: August Almén, Fredrik Björnström (later professor of psychiatry at the Karolinska institute), and Gustaf Kjellberg (the first professor of psychiatry in Uppsala) wrote in Proceedings of Upsala Medical Society in 1869–1870 on the new drug only a few months after Liebreich’s article, Das Chloralhydrat, ein Neues Hypnotikum, was published in Berlin. A delegation from Upsala Medical Society with Magnus Blix as its chairman carried out an investigation and published a report in Proceedings of The Upsala Medical Society in 1884 (6). keywords: almén; article; extract; förhandlingar; journal; lennander; liebig; läkareförenings; meat; medical; proceedings; professor; society; upsala; years cache: ujms-5844.pdf plain text: ujms-5844.txt item: #97 of 550 id: ujms-5845 author: Johansson, Henry title: The Uppsala anatomist Ivar Sandström and the parathyroid gland date: 2015-04-27 words: 3394 flesch: 55 summary: Submit your article to this journal Article views: 377 View related articles View Crossmark data Citing articles: 4 View citing articles https://www.tandfonline.com/action/journalInformation?journalCode=iups20 https://www.tandfonline.com/loi/iups20 https://doi.org/10.3109/03009734.2015.1027426 https://www.tandfonline.com/action/authorSubmission?journalCode=iups20&show=instructions https://www.tandfonline.com/action/authorSubmission?journalCode=iups20&show=instructions https://www.tandfonline.com/doi/mlt/10.3109/03009734.2015.1027426 https://www.tandfonline.com/doi/mlt/10.3109/03009734.2015.1027426 http://crossmark.crossref.org/dialog/?doi=10.3109/03009734.2015.1027426&domain=pdf&date_stamp=2015-04-27 http://crossmark.crossref.org/dialog/?doi=10.3109/03009734.2015.1027426&domain=pdf&date_stamp=2015-04-27 https://www.tandfonline.com/doi/citedby/10.3109/03009734.2015.1027426#tabModule https://www.tandfonline.com/doi/citedby/10.3109/03009734.2015.1027426#tabModule Upsala Journal of Medical Sciences. 2015; 120: 72–77 The Uppsala anatomist Ivar Sandström and the parathyroid gland HENRY JOHANSSON Department of Surgical Sciences, Uppsala University, Uppsala, Sweden Key words: Anatomy, endocrinology, parathyroid gland The last anatomical discovery The discovery of the parathyroid gland by the Uppsala anatomist Ivar Sandström (Figure 1) is often called the last anatomical discovery. In 1907 Jakob Erdheim, a Viennese pathologist, reported that patients dying of advanced skeletal disease frequently exhibited enlarged parathyroid glands (12). keywords: bone; discovery; disease; gland; ivar; parathyroid; sandström; surgery; uppsala cache: ujms-5845.pdf plain text: ujms-5845.txt item: #98 of 550 id: ujms-5846 author: Lindberg, Bo S. title: Physiology of the senses—a prominent area of science in Uppsala at the end of the nineteenth century date: 2015-04-20 words: 8298 flesch: 63 summary: Holmgren F. Om retinaströmmen. 1879–1880;3:278– 326. 4. Holmgren F. Om synpurpurn och retinaströmmen. keywords: alrutz; blind; blindness; blix; colour; förhandlingar; holmgren; light; läkareförenings; nerve; physiology; professor; retina; senses; skin; thunberg; upsala; vision; öhrvall cache: ujms-5846.pdf plain text: ujms-5846.txt item: #99 of 550 id: ujms-5847 author: Waldenström, Anders title: Johan Anton Waldenström, a versatile doctor and pioneer: Professor of medicine and practising surgeon date: 2015-04-10 words: 3837 flesch: 59 summary: Johan Anton Waldenström, a versatile doctor and pioneer: Professor of medicine and practising surgeo Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=iups20 Upsala Journal of Medical Sciences ISSN: 0300-9734 (Print) 2000-1967 (Online) Journal homepage: https://www.tandfonline.com/loi/iups20 Johan Anton Waldenström, a versatile doctor and pioneer: Professor of medicine and practising surgeon Anders Waldenström To cite this article: Anders Waldenström (2015) Johan Anton Waldenström, a versatile doctor and pioneer: Professor of medicine and practising surgeon, Upsala Journal of Medical Sciences, 120:2, 90-94 To link to this article: https://doi.org/10.3109/03009734.2015.1027427 © Informa Healthcare Published online: 10 Apr 2015. keywords: anton; att; case; doctor; johan; man; medical; medicine; och; operation; professor; time; waldenström; year cache: ujms-5847.pdf plain text: ujms-5847.txt item: #100 of 550 id: ujms-5848 author: Oreland, Lars title: Henrik Sjöbring and the concept of individual psychology in psychiatry date: 2015-04-23 words: 6318 flesch: 55 summary: Henrik Sjöbring and the concept of individual psychology in psychiatry 97 with ideas which somewhat resembled those that Sjöbring would present at a later date. Sjöbring personality dimensions: norms for some American populations. keywords: century; concept; henrik; individual; kretschmer; lund; och; personality; professor; psychiatry; psychology; sjöbring; theory; time; uppsala; work cache: ujms-5848.pdf plain text: ujms-5848.txt item: #101 of 550 id: ujms-5849 author: Lundblad, Arne title: Gunnar Blix and his discovery of sialic acids. Fascinating molecules in glycobiology date: 2015-04-28 words: 5479 flesch: 53 summary: Gunnar Blix and his discovery of sialic acids 107 A positive thing with the original experiment when crystals of sialic acid were discovered was that an optimal pH (2.5–3.5) had been chosen. Gunnar Blix and his discovery of sialic acids. keywords: acid; blix; cells; chemistry; discovery; figure; gunnar; medical; molecules; mucin; research; sialic; virus; years cache: ujms-5849.pdf plain text: ujms-5849.txt item: #102 of 550 id: ujms-5850 author: Westermark, Per title: Lars Grimelius and his silver impregnation method—Commentaries on the paper in Upsala Journal of Medical Sciences with the highest number of citations date: 2015-03-17 words: 2736 flesch: 53 summary: Lars Grimelius and his silver impregnation method—Commentaries on the paper in Upsala Journal of Med Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=iups20 Upsala Journal of Medical Sciences ISSN: 0300-9734 (Print) 2000-1967 (Online) Journal homepage: https://www.tandfonline.com/loi/iups20 Lars Grimelius and his silver impregnation method—Commentaries on the paper in Upsala Journal of Medical Sciences with the highest number of citations Per Westermark To cite this article: Per Westermark (2015) Lars Grimelius and his silver impregnation method—Commentaries on the paper in Upsala�Journal�of�Medical�Sciences with the highest number of citations, Upsala Journal of Medical Sciences, 120:2, 113-116 To link to this article: https://doi.org/10.3109/03009734.2015.1023910 © Informa Healthcare Published online: 17 Mar 2015. Submit your article to this journal Article views: 457 View related articles View Crossmark data https://www.tandfonline.com/action/journalInformation?journalCode=iups20 https://www.tandfonline.com/loi/iups20 https://doi.org/10.3109/03009734.2015.1023910 https://www.tandfonline.com/action/authorSubmission?journalCode=iups20&show=instructions https://www.tandfonline.com/action/authorSubmission?journalCode=iups20&show=instructions https://www.tandfonline.com/doi/mlt/10.3109/03009734.2015.1023910 https://www.tandfonline.com/doi/mlt/10.3109/03009734.2015.1023910 http://crossmark.crossref.org/dialog/?doi=10.3109/03009734.2015.1023910&domain=pdf&date_stamp=2015-03-17 http://crossmark.crossref.org/dialog/?doi=10.3109/03009734.2015.1023910&domain=pdf&date_stamp=2015-03-17 Upsala Journal of Medical Sciences. 2015; 120: 113–116 Lars Grimelius and his silver impregnation method—Commentaries on the paper in Upsala Journal of Medical Sciences with the highest number of citations PER WESTERMARK Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Key words: Amyloidosis, diabetes, hormones, pathology Citation counting is a comparably new procedure that has become widely used to evaluate single papers but also to rank journals by the so-called impact factor (IF), often determined to the third decimal. keywords: cells; grimelius; impregnation; journal; lars; medical; method; silver; upsala cache: ujms-5850.pdf plain text: ujms-5850.txt item: #103 of 550 id: ujms-5851 author: Westermark, Gunilla T.; Oskarsson, Marie; Andersson, Arne; Westermark, Per title: Eighty years of research on islet amyloidosis in Uppsala date: 2015-04-22 words: 3990 flesch: 46 summary: Islet amyloid in Uppsala 123 http://www.ncbi.nlm.nih.gov/pubmed/13657054?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/5723775?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/4443557?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/4443557?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/4443557?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/25263598?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/25263598?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/22424229?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/4940454?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/4116019?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/21641386?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/21641386?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/21641386?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/10679462?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/25700985?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/25700985?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/25700985?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/4632997?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/3535798?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/3535798?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/21742788?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/4129056?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/3073901?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/3073901?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/20369225?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/20369225?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/405771?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/405771?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/1884897?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/1884897?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/3930324?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/3930324?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/7635965?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/7635965?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/7937750?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/7937750?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/7489836?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/7489836?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/15000457?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/15000457?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/18753660?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/22193043?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/22193043?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/15983207?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/15929864?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/20160085?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/20160085?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/6375662?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/6375662?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/6375662?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/6236805?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/6236805?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/6236805?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/3159021?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/3159021?dopt=Abstract Introduction The first demonstration of islet amyloid in Uppsala Remarks by Gellerstedt on the histological appearance of islet amyloid Reappearance of islet amyloid research in Uppsala IAPP and the precipitation of islet amyloid Amyloidosis in transplanted islets Islet amyloidosis and Alzheimer’s disease—is there a link? Acknowledgement Declaration of interest References Reappearance of islet amyloid research in Uppsala Gellerstedt published some additional articles on senile amyloidosis but nothing more about islet amyloid. keywords: amyloid; amyloidosis; cells; diabetes; figure; gellerstedt; iapp; islet; research; studies; uppsala; westermark cache: ujms-5851.pdf plain text: ujms-5851.txt item: #104 of 550 id: ujms-5852 author: Andersson, Arne; Lau Börjesson, Joey title: Operating in an era of impact factor mania date: 2015-04-15 words: 3669 flesch: 57 summary: In the traditional measures released in late July from Thomson Reuters of journal impact factor figures self- citations are included, but for each journal there is information on their self-citation rates. The last sentence of that citation states that ‘The use of impact factor as a measure of quality is widespread because it fits well with the opinion we have in each field of the best journals in our speciality’. keywords: access; articles; factor; figure; impact; journal; medical; papers cache: ujms-5852.pdf plain text: ujms-5852.txt item: #105 of 550 id: ujms-5853 author: Wiklund, Lars; Johansson, Henry; Karlsson, Torbjörn title: Martin H:son Holmdahl date: 2015-05-15 words: 696 flesch: 41 summary: For Uppsala Medical Society Lars Wiklund, Henry Johansson, and Torbjörn Karlsson In memoriam: Martin Henriksson Holmdahl 133 ss1 Martin H:son Holmdahl, Upsala Journal of Medical Sciences, 120:2, 132-133 To link to this article: https://doi.org/10.3109/03009734.2015.1044055 © Informa Healthcare Published online: 05 May 2015. Submit your article to this journal Article views: 156 View related articles View Crossmark data https://www.tandfonline.com/action/journalInformation?journalCode=iups20 https://www.tandfonline.com/loi/iups20 https://doi.org/10.3109/03009734.2015.1044055 https://www.tandfonline.com/action/authorSubmission?journalCode=iups20&show=instructions https://www.tandfonline.com/action/authorSubmission?journalCode=iups20&show=instructions https://www.tandfonline.com/doi/mlt/10.3109/03009734.2015.1044055 https://www.tandfonline.com/doi/mlt/10.3109/03009734.2015.1044055 http://crossmark.crossref.org/dialog/?doi=10.3109/03009734.2015.1044055&domain=pdf&date_stamp=2015-05-05 http://crossmark.crossref.org/dialog/?doi=10.3109/03009734.2015.1044055&domain=pdf&date_stamp=2015-05-05 Upsala Journal of Medical Sciences. 2015; 120: 132–133 IN MEMORIAM Martin H:son Holmdahl Uppsala Medical Society has the sad duty to inform about the death of Martin H:son Holmdahl, who died in his 92nd year on 11 March 2015. keywords: holmdahl; martin cache: ujms-5853.pdf plain text: ujms-5853.txt item: #106 of 550 id: ujms-5854 author: Claesson-Welsh, Lena title: Vascular permeability—the essentials date: 2015-07-29 words: 6243 flesch: 30 summary: The current review aims to summarize current insights into different mechanisms of vascular permeability, its regulatory factors, and the consequences for disease. This review will discuss the current knowledge of how different types of vascular permeability are regulated, how regulation is lost in diseases, and, finally, how insights into regulatory mechanisms can be exploited therapeutically. keywords: angiogenesis; barrier; blood; brain; cadherin; cancer; cells; disease; endothelial; extravasation; growth; junctions; mechanisms; molecules; permeability; regulation; tissue; tumor; vascular; vasculature; vegf; vessels cache: ujms-5854.pdf plain text: ujms-5854.txt item: #107 of 550 id: ujms-5855 author: Nordenankar, Karin; Bergfors, Assar; Wallén-Mackenzie, Åsa title: Targeted deletion of Vglut2 expression in the embryonal telencephalon promotes an anxiolytic phenotype of the adult mouse date: 2015-04-09 words: 9046 flesch: 43 summary: ThefrequencyinthecentralcircleanddurationinthecentralcircleaswellasincentralfieldaresignificantlyincreasedfortheVglut2f/f;Emx1-Cre mice compared to control mice; the duration in the dark corner is significantly decreased in the Vglut2f/f;Emx1-Cre cKO mice compared to control mice (E). However, when analysing the number of mice that entered the outer open arm, we found that significantly more cKO than control mice actually visited this exposed area (chi-square, P = 0.010) keywords: activity; amygdala; amygdaloid; anxiety; brain; cko; cko mice; control; cre; deletion; expression; f;emx1; figure; glutamate; mice; mouse; nucleus; time; vglut1; vglut2 expression; vglut2f cache: ujms-5855.pdf plain text: ujms-5855.txt item: #108 of 550 id: ujms-5856 author: Ludvigsen, Eva; Carlsson, Carina; Tiensuu Janson, Eva; Sandler, Stellan; Stridsberg, Mats title: Somatostatin receptor 1–5; expression profiles during rat development date: 2015-04-30 words: 6835 flesch: 55 summary: It could be envisaged that embryonic islet cell expression of SSTRs may play a role in the further differentiation of islet cells. SSTRs mRNA expression in entire rat embryos Total RNA of rat embryos (n = 11) was collected from embryonal day 10 up to birth. keywords: + +; adult; cells; day; development; embryonic; embryos; expression; figure; mrna; n.i; newborn; pancreas; protein; rat; receptor; somatostatin; sstrs cache: ujms-5856.pdf plain text: ujms-5856.txt item: #109 of 550 id: ujms-5857 author: Zang, Guangxiang; Sandberg, Monica; Carlsson, Per-Ola; Welsh, Nils; Jansson, Leif; Barbu, Andreea title: Activated pancreatic stellate cells can impair pancreatic islet function in mice date: 2015-04-08 words: 8601 flesch: 47 summary: However, it should also be considered that PSCs-mediated elevation of insulin release into the medium resulted in a significant reduction in the insulin content of pancreatic islet cells. The diabetic pancreas is characterized by immu- nological (type 1 diabetes) or inflammatory (type 2 diabetes) reactions in which cytokines are important players, facilitating functional impairment and cytotoxic effects on pancreatic islet cells. keywords: beta; cells; culture; diabetes; effects; experiments; figure; glucose; il-6; insulin; islets; medium; mouse; pancreas; pancreatic; pscs; release; type cache: ujms-5857.pdf plain text: ujms-5857.txt item: #110 of 550 id: ujms-5858 author: Karlsson, Oskar; Colombo, Giancarlo; Roman, Erika title: Low copulatory activity in selectively bred Sardinian alcohol-nonpreferring (sNP) relative to alcohol-preferring (sP) rats date: 2015-03-02 words: 6223 flesch: 40 summary: sP rats, with an innate proclivity for high voluntary alcohol intake and high levels of anxiety-related behaviors, display sexual behavior similar to that of outbred Wistar rats when sexually experienced; sNP rats were considered sexually inactive, with characteristics of non- copulating males, suggesting a lower motivational drive. To gain more information about the sexual behavior in sP rats, Wistar rats were included as an external reference strain. keywords: activity; alcohol; behavior; copulatory; ejaculation; intromissions; latency; mounts; rats; snp; sp rats; test; wistar; wistar rats cache: ujms-5858.pdf plain text: ujms-5858.txt item: #111 of 550 id: ujms-5859 author: Leong, Ivone U. S.; Sucich, Jennifer; Prosser, Debra O.; Skinner, Jonathan R.; Crawford, Jackie R.; Higgins, Colleen; Love, Donald R. title: Array comparative genomic hybridization identifies a heterozygous deletion of exon 3 of the RYR2 gene date: 2015-04-02 words: 6027 flesch: 49 summary: has been used previously in screening for deletion/ duplication events in a large number of cardiac genes, but the design criteria have also been more generally applied to allow screening for mutations in non-car- diac-related referrals (15-18). Previous reports have found that approx- imately half of children with CPVT also present with seizures (27), and half of RYR2 gene mutation carriers A. B. 1,500 2,000 1,000 850 650 500 400 II3* III1 III2 III3 III4 Exon 3 1,568 bp Exon 3 aCGH: ~752 bp Actual: ~500 bp aCGH: 816 keywords: acgh; cardiac; cpvt; deletion; exon; figure; gene; mutations; proband; ryr2; tachycardia cache: ujms-5859.pdf plain text: ujms-5859.txt item: #112 of 550 id: ujms-5860 author: Henriques, Thomas; Cunningham, Bryan W.; Mcafee, Paul C.; Olerud, Claes title: In vitro biomechanical evaluation of four fixation techniques for distractive–flexion injury stage 3 of the cervical spine date: 2015-03-06 words: 5961 flesch: 43 summary: Anterior cervical plate fixation: biomechan- ical effectiveness as a function of posterior element injury. Anterior plate fixation has been reported to provide satisfactory results in cervical spine distractive flexion (DF) injuries stages 1 and 2, but will result in a substantial failure rate in more unstable stage 3 and above. keywords: analysis; cervical; construct; facet; fixation; flexion; injury; pedicle; plate; screws; spine; stability; techniques; wire cache: ujms-5860.pdf plain text: ujms-5860.txt item: #113 of 550 id: ujms-5861 author: Andersson, Arne title: Further improvements of our journal performance figures date: 2014-09-18 words: 1245 flesch: 64 summary: As pointed out at the very beginning of this edito- rial, the use of impact factor figures for measuring different quality aspects of scientific journals has been much debated. After a 33% increase last year and 21% this year we have now established ourselves in the 1.0– 2.0 interval with the new figure of 1.708 as a new top score for the journal. keywords: figure; impact; journal; year cache: ujms-5861.pdf plain text: ujms-5861.txt item: #114 of 550 id: ujms-5862 author: Westermark, Bengt title: Platelet-derived growth factor in glioblastoma—driver or biomarker? date: 2014-10-24 words: 5802 flesch: 38 summary: Kumabe T, Sohma Y, Kayama T, Yoshimoto T, Yamamoto T. Overexpression and amplification of alpha- PDGF receptor gene lacking exons coding for a portion of the extracellular region in a malignant glioma. PDGF and PDGF receptors The platelet-derived growth factor (PDGF) family consists of covalently linked hetero- or homodimers of A-, B-, C-, and D-chains (PDGF-AA, -AB, -BB, -CC, and -DD) (for comprehensive reviews on PDGF and PDGF receptors, see (17,18)). keywords: activation; brain; cancer; cell; development; factor; gbm; gene; glioblastoma; glioma; growth; growth factor; mice; pdgf; platelet; receptor; tumors; virus; westermark cache: ujms-5862.pdf plain text: ujms-5862.txt item: #115 of 550 id: ujms-5867 author: Rottenberg, Eric M title: Re: Neural injury after use of vasopressin and adrenaline during porcine cardiopulmonary resuscitation date: 2015-03-15 words: 1017 flesch: 14 summary: The elevation of intratho- racic pressure during chest compression generates carotid pressure and flow but also increases ICP, which may be what limits cerebral blood flow (5-7). Eric M Rottenberg (2015) Re: Neural injury after use of vasopressin and adrenaline during porcine cardiopulmonary resuscitation, Upsala Journal of Medical Sciences, 120:3, 213-214, DOI: 10.3109/03009734.2015.1021936 To link to this article: https://doi.org/10.3109/03009734.2015.1021936 keywords: injury; resuscitation; use; vasopressin cache: ujms-5867.pdf plain text: ujms-5867.txt item: #116 of 550 id: ujms-5868 author: Saleh, Amin J.; Zhang, Liangbin; Hadi, Sally M.; Ouyang, Wen title: A priming dose of intravenous ketamine-dexmedetomidine suppresses fentanyl-induced coughing: A double-blind, randomized, controlled study date: 2014-11-04 words: 3542 flesch: 41 summary: Only nine patients in the KETODEX group had either mild (6%) or moderate (3%) cough, with none suffering from severe cough (Table II). Only nine patients in the KETODEX group had either mild (6%) or moderate (3%) cough, with none suffering from severe cough. Conclusion. keywords: cough; coughing; dexmedetomidine; fentanyl; fic; group; ketamine; ketodex; patients; study cache: ujms-5868.pdf plain text: ujms-5868.txt item: #117 of 550 id: ujms-5869 author: Kharazmi, Mohammad; Björnstad, Lillemor; Hallberg, Pär; Wanbro, Jonas; Carlsson, Anders-Petter; Habib, Samandar; Warfvinge, Gunnar title: Mandibular bone exposure and osteonecrosis as a complication of general anaesthesia date: 2015-03-17 words: 1292 flesch: 41 summary: Within 1 week Case 1b 69M Posterior, right side of mandible 4.5 No (plain X-ray) Oral pain Immediately after recovery Amoxicillin. Mandibular bone exposure and osteonecrosis as a complication of general anaesthesia, Upsala Journal of Medical Sciences, 120:3, 215-216, DOI: 10.3109/03009734.2015.1010667 To link to this article: https://doi.org/10.3109/03009734.2015.1010667 © Informa Healthcare Published online: 17 Mar 2015. keywords: anaesthesia; mandible; osteonecrosis; surgery cache: ujms-5869.pdf plain text: ujms-5869.txt item: #118 of 550 id: ujms-5870 author: He, Liang; Xu, Jun-Mei; He, Tao; Liu, Lei; Zhu, Rong title: Dexmedetomidine pretreatment alleviates propofol injection pain date: 2014-10-12 words: 3665 flesch: 47 summary: We hypothesized that DEX injection before pro- pofol would reduce propofol injection pain. Dexmedetomidine pretreatment alleviates propofol injection pain Upsala Journal of Medical Sciences. 2014; 119: 338–342 ORIGINAL ARTICLE Dexmedetomidine pretreatment alleviates propofol injection pain LIANG HE1, JUN-MEI XU2, TAO HE1, LEI LIU2 & RONG ZHU2 1Department of Anesthesiology, Loudi Central Hospital of University of South China, Loudi 417000, Hunan Province, China, and 2Department of Anesthesiology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China Abstract Objective. keywords: analgesic; dex; dexmedetomidine; group; injection; injection pain; pain; patients; propofol; propofol injection; study cache: ujms-5870.pdf plain text: ujms-5870.txt item: #119 of 550 id: ujms-5871 author: Olofsson, Parvin Tavakol; Aspelin, Peter; Bergstrand, Lott; Blomqvist, Lennart title: Patients’ experience of outsourcing and care related to magnetic resonance examinations date: 2014-08-21 words: 4148 flesch: 46 summary: To examine the experiences of patients who are sent to private radiology units when their referrals for MR examinations are outsourced from a university hospital, as well as to explore factors which influence patient satisfaction regarding the quality of care related to the MR examination. If patients were informed about outsourcing and could also choose where to have their examination, key factors contributing to patient satisfaction could be met even when MR examinations are outsourced. keywords: care; department; examinations; outsourcing; patients; radiology; satisfaction cache: ujms-5871.pdf plain text: ujms-5871.txt item: #120 of 550 id: ujms-5928 author: Feng, Ji-Feng; Huang, Ying; Zhao, Qiang title: Tumor length in elderly patients with esophageal squamous cell carcinoma: Is it a prognostic factor? date: 2013-04-26 words: 4834 flesch: 65 summary: However, there have been few studies regarding tumor length in elderly EC patients (6,7). Esophageal tumor length is inde- pendently associated with long-term survival. keywords: cancer; escc; esophageal; length; patients; prognostic; survival; tumor; tumor length cache: ujms-5928.pdf plain text: ujms-5928.txt item: #121 of 550 id: ujms-5929 author: Wide, Leif; Eriksson, Karin title: Dynamic changes in glycosylation and glycan composition of serum FSH and LH during natural ovarian stimulation date: 2013-03-25 words: 7904 flesch: 63 summary: Results FSH and LH serum concentrations Menstrual cycle FSH and LH glycosylation 157 Numbers of SA and SU residues per FSH and LH molecule keywords: ams; cycle; day; fsh; fshdi; lhdi; mean; menstrual; molecule; number; residues; serum cache: ujms-5929.pdf plain text: ujms-5929.txt item: #122 of 550 id: ujms-5931 author: Nyholm, Lena; Howells, Tim; Enblad, Per; Lewén, Anders title: Introduction of the Uppsala Traumatic Brain Injury register for regular surveillance of patient characteristics and neurointensive care management including secondary insult quantification and clinical outcome date: 2013-07-10 words: 8143 flesch: 51 summary: Mean occurrence of secondary insults (% of GMT) according to predefined threshold levels (mmHg) in TBI patients with ICP monitoring ‡16 years (n = 146) and in deteriorated patients ‡16 years (n = 20), included in the Uppsala TBI register 2008–2010. Our impression is that the standardized summary reports on demand provide a valuable tool to monitor demographic changes over time and the quality of NIC in TBI patients. keywords: brain; care; injury; management; nic; outcome; patients; register; rls; table; tbi; unit; uppsala cache: ujms-5931.pdf plain text: ujms-5931.txt item: #123 of 550 id: ujms-5932 author: Strang, Susann; Ekberg-Jansson, Ann; Strang, Peter; Larsson, Lars-Olof title: Palliative care in COPD—web survey in Sweden highlights the current situation for a vulnerable group of patients date: 2013-05-28 words: 4691 flesch: 46 summary: (4) Are there any plans at your unit to develop, or further develop, palliative care services for patients with COPD? (5) According to WHO, palliative care is focused on physical, psychological, social, and existential dimensions. Despite the heavy symptom burden in late stages, these patients are relatively seldom referred to specialist palliative care. keywords: care; copd; dimensions; disease; existential; health; palliative; patients; physicians; pulmonary; respondents; survey; sweden cache: ujms-5932.pdf plain text: ujms-5932.txt item: #124 of 550 id: ujms-5933 author: Wånggren, Kjell; Prag, Frida; Skoog Svanberg, Agneta title: Attitudes towards embryo donation in Swedish women and men of reproductive age date: 2013-06-20 words: 6090 flesch: 55 summary: Attitudes towards embryo donation in Swedish women and men of reproductive age Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=iups20 Upsala Journal of Medical Sciences ISSN: 0300-9734 (Print) 2000-1967 (Online) Journal homepage: https://www.tandfonline.com/loi/iups20 Attitudes towards embryo donation in Swedish women and men of reproductive age Kjell Wånggren, Frida Prag & Agneta Skoog Svanberg To cite this article: Kjell Wånggren, Frida Prag & Agneta Skoog Svanberg (2013) Attitudes towards embryo donation in Swedish women and men of reproductive age, Upsala Journal of Medical Sciences, 118:3, 187-195, DOI: 10.3109/03009734.2013.808294 To link to this article: keywords: age; attitudes; couples; donation; embryo; embryo donation; recipient; study; sweden; women; years cache: ujms-5933.pdf plain text: ujms-5933.txt item: #125 of 550 id: ujms-5934 author: Tsoukalas, Nikolaos; Kostakis, Ioannis D.; Demiri, Stamatina; Koumakis, Georgios; Barbounis, Vasileios; Barbati, Kalypso; Efremidis, Anna title: Neoplastic pericarditis as the initial manifestation of a papillary thyroid carcinoma date: 2013-05-13 words: 1810 flesch: 34 summary: Neoplastic pericardial effusion. On the other hand, malignant pericardial effusion (14,15) or cardiac tam- ponade (11) have also been diagnosed in patients with already diagnosed thyroid cancer. keywords: cancer; carcinoma; effusion; manifestation; pericarditis; tamponade; thyroid cache: ujms-5934.pdf plain text: ujms-5934.txt item: #126 of 550 id: ujms-5936 author: Machaczka, Maciej title: Hemophagocytic lymphohistiocytosis in adults date: 2013-05-17 words: 1782 flesch: 43 summary: The article by Antonodimitrakis and colleagues is a valuable voice in the debate over adult HLH. Declaration of interest: The author reports no conflicts of interest. Although FHL usually arises in infants and the vast majority of HLH cases in adults are acquired, it should be stressed that, albeit rarely, FHL can occur in adulthood, including older indivi- duals (so-called late-onset FHL) (3–5). keywords: adults; hlh; lymphohistiocytosis cache: ujms-5936.pdf plain text: ujms-5936.txt item: #127 of 550 id: ujms-5937 author: Bulbul Sen, Bilge; Nur Rifaioglu, Emine; Ekiz, Ozlem; Buyukkaya, Eyup ; Sen, Nihat title: Is there a relationship between disease duration and P-wave dispersion in patients with psoriasis? date: 2013-03-23 words: 1054 flesch: 49 summary: They concluded that Pmax and P-wave dispersion (PWD) were signifi- cantly higher in psoriasis patients than in controls (108.8 ± 21.3 ms versus 93.3 ± 13.0 ms, P < 0.01; 67.4 ± 22.9 ms versus 45.0 ± 19.6 ms, P < 0.01, respectively). It has been postulated that premature occurrence of atherosclerosis is related to why psoriasis patients have an increased risk for developing cardiovascular dis- ease. keywords: disease; patients; psoriasis cache: ujms-5937.pdf plain text: ujms-5937.txt item: #128 of 550 id: ujms-5938 author: Purnak, Tugrul; Beyazit, Yavuz; Efe, Cumali; Ozaslan, Ersan ; Yuksel, Osman; Altiparmak, Emin title: Authors' reply: ‘Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease' date: 2013-07-10 words: 721 flesch: 29 summary: i Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=iups20 Upsala Journal of Medical Sciences ISSN: 0300-9734 (Print) 2000-1967 (Online) Journal homepage: https://www.tandfonline.com/loi/iups20 Authors' reply: ‘Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease' Tugrul Purnak, YAVUZ BEYAZIT, CUMALI EFE, ERSAN OZASLAN, OSMAN YUKSEL & EMIN ALTIPARMAK To cite this article: Tugrul Purnak, YAVUZ BEYAZIT, CUMALI EFE, ERSAN OZASLAN, OSMAN YUKSEL & EMIN ALTIPARMAK (2013) Authors' reply: ‘Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease', Upsala Journal of Medical Sciences, 118:3, 208-208, DOI: 10.3109/03009734.2013.806617 To link to this article: https://doi.org/10.3109/03009734.2013.806617 © Informa Healthcare Published online: 10 Jul 2013. Finally, we find Dr Varol’s hypothesis very intrigu- ing regarding a relationship between celiac disease and cardiovascular disease. keywords: disease; platelet; volume cache: ujms-5938.pdf plain text: ujms-5938.txt item: #129 of 550 id: ujms-5939 author: Varol, Ercan title: Comment on: ‘Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease’ date: 2013-06-19 words: 816 flesch: 29 summary: Comment on: ‘Mean platelet volume could be a promising biomarker to monitor dietary compliance in ce Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=iups20 Upsala Journal of Medical Sciences ISSN: 0300-9734 (Print) 2000-1967 (Online) Journal homepage: https://www.tandfonline.com/loi/iups20 Comment on: ‘Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease’ Ercan Varol To cite this article: Ercan Varol (2013) Comment on: ‘Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease’, Upsala Journal of Medical Sciences, 118:3, 206-207, DOI: 10.3109/03009734.2013.803503 To link to this article: https://doi.org/10.3109/03009734.2013.803503 © Informa Healthcare Published online: 19 Jun 2013. They concluded that MPV could be a useful clinical marker for monitoring of dietary compliance in celiac disease patients. keywords: disease; mean; platelet; volume cache: ujms-5939.pdf plain text: ujms-5939.txt item: #130 of 550 id: ujms-5940 author: Jansson, Leif; Kampf, Caroline; Källskog, Örjan title: Functional stimulation of graft nerves has minor effects on insulin release from transplanted rat pancreatic islets date: 2013-08-27 words: 5867 flesch: 45 summary: Functional stimulation of graft nerves has minor effects on insulin release from transplanted rat pa Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=iups20 Upsala Journal of Medical Sciences ISSN: 0300-9734 (Print) 2000-1967 (Online) Journal homepage: https://www.tandfonline.com/loi/iups20 Functional stimulation of graft nerves has minor effects on insulin release from transplanted rat pancreatic islets Leif Jansson, Caroline Kampf & Örjan Källskog To cite this article: Leif Jansson, Caroline Kampf & Örjan Källskog (2013) Functional stimulation of graft nerves has minor effects on insulin release from transplanted rat pancreatic islets, Upsala Journal of Medical Sciences, 118:4, 209-216, DOI: 10.3109/03009734.2013.818601 To link to this article: https://doi.org/10.3109/03009734.2013.818601 © Informa Healthcare Published online: 27 Aug 2013. Submit your article to this journal Article views: 380 View related articles https://www.tandfonline.com/action/journalInformation?journalCode=iups20 https://www.tandfonline.com/loi/iups20 https://www.tandfonline.com/action/showCitFormats?doi=10.3109/03009734.2013.818601 https://doi.org/10.3109/03009734.2013.818601 https://www.tandfonline.com/action/authorSubmission?journalCode=iups20&show=instructions https://www.tandfonline.com/action/authorSubmission?journalCode=iups20&show=instructions https://www.tandfonline.com/doi/mlt/10.3109/03009734.2013.818601 https://www.tandfonline.com/doi/mlt/10.3109/03009734.2013.818601 Upsala Journal of Medical Sciences. 2013; 118: 209–216 ORIGINAL ARTICLE Functional stimulation of graft nerves has minor effects on insulin release from transplanted rat pancreatic islets LEIF JANSSON1, CAROLINE KAMPF2 & ÖRJAN KÄLLSKOG1 1Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden, and 2Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Abstract Introduction. keywords: blood; control; figure; graft; insulin; islets; nerves; pancreatic; rats; renal; stimulation; transplantation; transplanted; vein cache: ujms-5940.pdf plain text: ujms-5940.txt item: #131 of 550 id: ujms-5941 author: Stridh, Sara; Palm, Fredrik; Hansell, Peter title: Inhibition of hyaluronan synthesis in rats reduces renal ability to excrete fluid and electrolytes during acute hydration date: 2013-09-09 words: 3543 flesch: 42 summary: After completion of the experimental procedure, the kidneys were excised and weighed, and samples from cortex and inner medulla (papilla) were taken and frozen for subsequent analysis of HA content. Measurement of HA content Excised and frozen samples of kidney tissue were dried at 68�C over night, then disrupted in 0.5 M NaCl (FP120, Thermo Electron Corporation, Mar- ietta, Ohio, USA). keywords: control; fluid; hyaluronan; hydration; kidney; rats cache: ujms-5941.pdf plain text: ujms-5941.txt item: #132 of 550 id: ujms-5942 author: Roman, Erika; Karlsson, Oskar title: Increased anxiety-like behavior but no cognitive impairments in adult rats exposed to constant light conditions during perinatal development date: 2013-08-01 words: 4862 flesch: 49 summary: The animals were maintained on standard lab chow and water ad libi- tum, and were housed in temperature-controlled (21 ± 1�C) and humidity-controlled (50% ± 10%) cabinets in an animal room with a 12-h light/ dark cycle (lights on at 6 a.m.). Parameters Control LL A: Open field test 1 Total activity 56 ± 4 36 ± 3** Rearing 24 ± 1 28 ± 2 Outer circle FRQ 20 ± 1 14 ± 1** DUR 482 ± 9 522 ± 12* DUR/FRQ 25 ± 2 39 ± 2** Middle circle LAT 9 ± 2 32 ± 5** FRQ 28 ± 2 17 ± 1** DUR 97 ± 7 67 ± 11* DUR/FRQ 3.6 ± 0.2 3.8 ± 0.6 Center LAT 72 ± 20 135 ± 24 FRQ 8 ± 1 4 ± 1* DUR 23 ± 3 12 ± 1 DUR/FRQ 2.8 ± 0.3 3.2 ± 0.2 B: Open field test 2 Total activity 52 ± 4 35 ± 3* Rearing 25 ± 1 27 ± 2 Outer circle FRQ 18 ± 1 13 ± 1* DUR 489 ± 8 525 ± 7* DUR/FRQ 29 ± 3 46 ± 6* Middle circle LAT 40 ± 16 70 ± 22 FRQ 26 ± 2 17 ± 2* DUR 84 ± 8 57 ± 5* DUR/FRQ 3.3 ± 0.2 3.4 ± 0.3 Center LAT 95 ± 21 151 ± 13 FRQ 8 ± 1 5 ± 1* DUR 29 ± 3 19 ± 3 DUR/FRQ 3.7 ± 0.5 3.7 ± 0.2 DUR = duration (s), total time spent in zone; DUR/ FRQ = duration per visit (s); FRQ = frequency, number of visits; LAT = latency (s), time to first visiting a zone; Rearing = total number of rearings; Total activity = total number of visits to the defined zones. keywords: animals; behavior; controls; development; frq; group; light; rats; test cache: ujms-5942.pdf plain text: ujms-5942.txt item: #133 of 550 id: ujms-5943 author: Arinc, Huseyin; Sarli, Bahadir; Oguz Baktir, Ahmet; Saglam, Hayrettin; Demirci, Erkan; Dogan, Yasemin; Kurtul, Serkan; Karaman, Hatice; Erden, Abdulsamet; Karaman, Ahmet title: Serum gamma glutamyl transferase and alanine transaminase concentrations predict endothelial dysfunction in patients with non-alcoholic steatohepatitis date: 2013-07-08 words: 4382 flesch: 40 summary: Accuracy of b-GGT fraction for the diagnosis of non-alcoholic fatty liver disease. Patients with elevated liver enzymes in the absence of alcohol consumption and secondary causes of liver disease are described as having NAFLD (2). keywords: alt; artery; concentrations; disease; dysfunction; gamma; ggt; glutamyl; liver; nash; patients; serum; transferase cache: ujms-5943.pdf plain text: ujms-5943.txt item: #134 of 550 id: ujms-5944 author: Yang, Lin; Xu, Jun-Mei; Jiang, XingHua; Ruan, Wei; Cui, YuLong; He, Liang title: Effect of dexmedetomidine on plasma brainderived neurotrophic factor: A double-blind, randomized and placebo-controlled study date: 2013-06-20 words: 3901 flesch: 48 summary: BDNF in blood could readily be detected, and according to previous studies it is highly correlated with BDNF concentrations in the brain (3,4). Baseline plasma concentrations of BDNF did not differ between group A and group B; 15 minutes after induction, concentrations of plasma BDNF were significantly reduced in group A. Twenty-four hours after surgery, the concentration was still higher in group B than in group A. keywords: anesthetics; bdnf; brain; concentrations; dex; factor; group; induction; minutes; patients; plasma cache: ujms-5944.pdf plain text: ujms-5944.txt item: #135 of 550 id: ujms-5945 author: Höglund, Niklas; Rönn, Folke; Tollefsen, Titti; Jensen, Steen M.; Kesek, Milos title: U22 protocol as measure of symptomatic improvement after catheter ablation of atrial fibrillation date: 2013-10-19 words: 4789 flesch: 47 summary: Left atrial catheter ablation is useful as symptomatic treatment in selected patients with atrial fibrillation (AF). Keywords: Arrhythmia symptoms, atrial fibrillation, catheter ablation, quality of life, symptom-specific protocol Introduction Left atrial catheter ablation is a suitable treatment in selected patients with atrial fibrillation. keywords: ablation; arrhythmia; fibrillation; follow; improvement; patients; scores; sf-36; symptoms; time; u22 cache: ujms-5945.pdf plain text: ujms-5945.txt item: #136 of 550 id: ujms-5947 author: Nyberg, Sofia ; Gerring, Edvard; Gjellan, Solveig; Vergara, Marta; Lindström, Torbjörn; Nystrom, Fredrik H title: Effects of exercise with or without blueberries in the diet on cardio-metabolic risk factors: An exploratory pilot study in healthy subjects date: 2013-08-27 words: 7035 flesch: 51 summary: Variable Baseline before exercise period After 4 weeks of exercise Baseline before minimal physical activity period After 4 weeks of minimal physical activity P for difference between the end of the two periods P for difference of delta values between the two periods FS-insulin (pmol/l) All 57 ± 25 49 ± 17 54 ± 17 58 ± 17 0.015 0.009 Women 54 ± 25 49 ± 20 58 ± 19 62 ± 17 0.16 0.14 Men 59 ± 26 49 ± 16 51 ± 16 55 ± 17 0.044 0.038 S-CK before race (mkat/l) Analyzed in the same manner, triglyceride levels also decreased the morning after a running-race (levels before 0.99 ± 0.52 mmol/l; after 0.88 ± 0.45 mmol/l, P = 0.008), while levels of HDL-cholesterol or LDL-cholesterol did not change significantly (not shown). keywords: activity; blueberries; cholesterol; effects; exercise; levels; participants; period; race; running; study; troponin cache: ujms-5947.pdf plain text: ujms-5947.txt item: #137 of 550 id: ujms-5948 author: Engström, Sevek; Borgquist, Lars; Berne, Christian; Gahnberg, Lars; Svärdsudd, Kurt title: Can costs of screening for hypertension and diabetes in dental care and follow-up in primary health care be predicted? date: 2013-08-19 words: 4936 flesch: 53 summary: Altogether, 1,149 were screened for blood pressure regardless of blood glucose screening, and 1,568 were screened for blood glucose regardless of blood pressure screening. 47,4 140 Total follow-up costs per subject 91 58 58 91 57 83 Number of subjects with diagnosis found 76 9 9 1 4 80 Numbers needed to screen (NNS) 18 196 96 55 119 15 Total resource use per screened Total time used 25.2 18.0 19.7 23.1 16.7 42.7 Analysis costs 0 0.77 0.80 0 0.74 0.77 Total resource use per diagnosed subject Total time used 563 3,137 1,677 1,272 1,988 583 BPS = blood pressure screening; BGS = blood glucose screening. keywords: blood; blood pressure; care; costs; diabetes; follow; glucose; health; pressure; screening; study; time cache: ujms-5948.pdf plain text: ujms-5948.txt item: #138 of 550 id: ujms-5949 author: Gottvall, Maria; Grandahl, Maria; Höglund, Anna T.; Larsson, Margareta; Stenhammar, Christina; Andrae, Bengt ; Tydén, Tanja title: Trust versus concerns—how parents reason when they accept HPV vaccination for their young daughter date: 2013-06-19 words: 5356 flesch: 50 summary: Trust versus concerns—how parents reason when they accept HPV vaccination for their young daughter Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=iups20 Upsala Journal of Medical Sciences ISSN: 0300-9734 (Print) 2000-1967 (Online) Journal homepage: https://www.tandfonline.com/loi/iups20 Trust versus concerns—how parents reason when they accept HPV vaccination for their young daughter Maria Gottvall, Maria Grandahl, Anna T. Höglund, Margareta Larsson, Christina Stenhammar, Bengt Andrae & Tanja Tydén To cite this article: Maria Gottvall, Maria Grandahl, Anna T. Höglund, Margareta Larsson, Christina Stenhammar, Bengt Andrae & Tanja Tydén (2013) Trust versus concerns—how parents reason when they accept HPV vaccination for their young daughter, Upsala Journal of Medical Sciences, 118:4, 263-270, DOI: 10.3109/03009734.2013.809039 To link to this article: Citing articles: 23 View citing articles https://www.tandfonline.com/action/journalInformation?journalCode=iups20 https://www.tandfonline.com/loi/iups20 https://www.tandfonline.com/action/showCitFormats?doi=10.3109/03009734.2013.809039 https://doi.org/10.3109/03009734.2013.809039 https://www.tandfonline.com/action/authorSubmission?journalCode=iups20&show=instructions https://www.tandfonline.com/action/authorSubmission?journalCode=iups20&show=instructions https://www.tandfonline.com/doi/mlt/10.3109/03009734.2013.809039 https://www.tandfonline.com/doi/mlt/10.3109/03009734.2013.809039 https://www.tandfonline.com/doi/citedby/10.3109/03009734.2013.809039#tabModule https://www.tandfonline.com/doi/citedby/10.3109/03009734.2013.809039#tabModule Upsala Journal of Medical Sciences. 2013; 118: 263–270 ORIGINAL ARTICLE Trust versus concerns—how parents reason when they accept HPV vaccination for their young daughter MARIA GOTTVALL1*, MARIA GRANDAHL1*, ANNA T. HÖGLUND1, MARGARETA LARSSON2, CHRISTINA STENHAMMAR1, BENGT ANDRAE3 & TANJA TYDÉN1 1Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden, 2Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden, and 3Centre for Research and Development, Uppsala University/County Council of Gävleborg, Gävle, Sweden Abstract Background. keywords: daughter; hpv; hpv vaccination; information; interview; parents; programme; school; trust; vaccination; vaccine cache: ujms-5949.pdf plain text: ujms-5949.txt item: #139 of 550 id: ujms-5950 author: Ekstrand, Maria; Tydén, Tanja; Darj, Elisabeth; Larsson, Margareta title: Twelve-month follow-up of advance provision of emergency contraception among teenage girls in Sweden—a randomized controlled trial date: 2020-10-09 words: 3231 flesch: 46 summary: Twelve-month follow-up of advance provision of emergency contraception among teenage girls in Sweden Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=iups20 Upsala Journal of Medical Sciences ISSN: 0300-9734 (Print) 2000-1967 (Online) Journal homepage: https://www.tandfonline.com/loi/iups20 Twelve-month follow-up of advance provision of emergency contraception among teenage girls in Sweden—a randomized controlled trial Maria Ekstrand, Tanja Tydén, Elisabeth Darj & Margareta Larsson To cite this article: Maria Ekstrand, Tanja Tydén, Elisabeth Darj & Margareta Larsson (2013) Twelve-month follow-up of advance provision of emergency contraception among teenage girls in Sweden—a randomized controlled trial, Upsala Journal of Medical Sciences, 118:4, 271-275, DOI: 10.3109/03009734.2013.841308 To link to this article: https://doi.org/10.3109/03009734.2013.841308 © Informa Healthcare Published online: 09 ISSN 0300-9734 print/ISSN 2000-1967 online � 2013 Informa Healthcare DOI: 10.3109/03009734.2013.841308 http://informahealthcare.com/journal/ups mailto:Maria.Ekstrand@mah.se Since most studies evaluating advance provision of emergency contraception have only conducted a 6-month follow-up post intervention, the aim of this study was to evaluate an intervention of advance provision of ECP to teenage girls, 12 months after enrolment. keywords: advance; ecp; follow; girls; group; provision cache: ujms-5950.pdf plain text: ujms-5950.txt item: #140 of 550 id: ujms-5951 author: Kawati, Rafael; Larsson, Anders title: Brain death due to fat embolism — could moderate hypercapnia and prone position be blamed for the tonsillar herniation? date: 2013-08-27 words: 1695 flesch: 43 summary: Brain death due to fat embolism — could moderate hypercapnia and prone position be blamed for the to Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=iups20 Upsala Journal of Medical Sciences ISSN: 0300-9734 (Print) 2000-1967 (Online) Journal homepage: https://www.tandfonline.com/loi/iups20 Brain death due to fat embolism — could moderate hypercapnia and prone position be blamed for the tonsillar herniation? Rafael Kawati & Anders Larsson To cite this article: Rafael Kawati & Anders Larsson (2013) keywords: brain; cerebral; embolism; fat; patient; position cache: ujms-5951.pdf plain text: ujms-5951.txt item: #141 of 550 id: ujms-5952 author: Hron, Gregor; Knutson, Folke; Thiele, Thomas; Althaus, Karina; Busemann, Christoph; Friesecke, Sigrun; Greinacher, Andreas; Lubenow, Norbert title: Alternative diagnosis to heparin-induced thrombocytopenia in two critically ill patients despite a positive PF4/heparin-antibody test date: 2013-10-09 words: 3819 flesch: 38 summary: The particle-gel immunoassay for anti-PF4/heparin-antibodies (patient 2) as well as the anti-heparin/PF4 ELISA (both patients) has a high sensitivity but low specificity for clinical HIT (22). Early-onset and persisting thrombocyto- penia in post-cardiac surgery patients is rarely due to heparin-- induced thrombocytopenia, even when antibody tests are positive. keywords: antibodies; count; day; diagnosis; heparin; hit; patient; pf4; platelet; thrombocytopenia; transfusion cache: ujms-5952.pdf plain text: ujms-5952.txt item: #142 of 550 id: ujms-5954 author: Chakraborty, Subhankar; Dimaio, Dominick; Vanschooneveld, Trevor title: Palpable maculopapular rash with elevated ESR: What is your diagnosis? date: 2013-06-27 words: 973 flesch: 34 summary: We present a case of drug rash resembling LCV. A diagnosis of drug rash was made, presumably due to oxacillin. keywords: diagnosis; drug; medical; rash cache: ujms-5954.pdf plain text: ujms-5954.txt item: #143 of 550 id: ujms-5955 author: Andersson, Arne; Ronquist, Gunnar title: A substantial increase of the impact factor date: 2012-10-30 words: 1066 flesch: 58 summary: The review by Niklas Nordquist and Lars Oreland on ‘Serotonin, genetic variability, behaviour, and psychi- atric disorders’ (2) was cited 16 times last year and then was responsible for more than 20% of the citations to the 2010 and 2011 volumes last year. For that type of calcula- tions citations during the publication year and the two following years are counted. keywords: impact; journal; year cache: ujms-5955.pdf plain text: ujms-5955.txt item: #144 of 550 id: ujms-5956 author: Tengholm, Anders title: Cyclic AMP dynamics in the pancreatic β-cell date: 2012-09-13 words: 11328 flesch: 60 summary: Yajima H, Komatsu M, Schermerhorn T, Aizawa T, Kaneko T, Nagai M, et al. cAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel-independent pathway of glucose signaling in rat pancreatic islets. Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1. keywords: activation; atp; ca2; ca2+]i; camp; cells; cyclic; diabetes; effects; epac2; exocytosis; glucose; insulin; insulin secretion; islets; kinase; mouse; oscillations; pancreatic; physiol; pka; protein; pulsatile; rat; regulation; release; signaling; type cache: ujms-5956.pdf plain text: ujms-5956.txt item: #145 of 550 id: ujms-5957 author: Zhang, Wang; Si, Liang-yi title: Obstructive sleep apnea syndrome (OSAS) and hypertension: Pathogenic mechanisms and possible therapeutic approaches date: 2012-09-25 words: 10268 flesch: 58 summary: Obstructive sleep apnea (OSA) is a condition in which there is repetitive partial or complete collapse of the pharynx during sleep. The improve- ment of obstructive sleep apnea after weight loss might be related to improvement in pharyngeal and glottic function (159). keywords: airway; apnea syndrome; association; blood; blood pressure; breathing; crit; disordered; dysfunction; endothelial; et al; factors; heart; hypertension; hypoxia; intermittent; med; nocturnal; obesity; osas; osas patients; patients; pressure; prevalence; respir; risk; sleep; sleep apnea; studies; study; syndrome cache: ujms-5957.pdf plain text: ujms-5957.txt item: #146 of 550 id: ujms-5958 author: Subhan, Mirza M. F.; Ali, Syed A.; Bokhari, Syed S. I.; Khan, Mohammed N.; Ahmad, Hakimuddin R. title: Underweight and overweight men have greater exercise-induced dyspnoea than normal weight men date: 2012-08-30 words: 5219 flesch: 63 summary: The greater levels of dyspnoea in UW subjects could possibly be due to decreased RMS. Schachter et al. suggested that an inferior lung function of UW subjects could be due to a decrease in RMS (17). keywords: bmi; body; dyspnoea; exercise; fvc; mass; study; subjects; vas cache: ujms-5958.pdf plain text: ujms-5958.txt item: #147 of 550 id: ujms-5959 author: Zhong, Yucheng; Tang, Hongxia; Zeng, Qiutang ; Wang, Xiang; Yi, Guiwen; Meng, Kai; Mao, Yi; Mao, Xiaobo title: Total cholesterol content of erythrocyte membranes is associated with the severity of coronary artery disease and the therapeutic effect of rosuvastatin date: 2012-09-25 words: 6985 flesch: 67 summary: Our study was designed to investigate the association between CEM and the severity of coronary artery disease (CAD), and to assess the effect of rosuvastatin on CEM levels. CEM levels were assessed in 136 participants, including acute coronary syndrome (ACS) (non-ST-segment elevation ACS (NSTEACS) and ST-segment elevation myocardial infarction (STEMI)), stable angina pectoris (SAP), and controls. keywords: artery; cad; cem; cholesterol; coronary; group; levels; patients cache: ujms-5959.pdf plain text: ujms-5959.txt item: #148 of 550 id: ujms-5960 author: Sasaji, Tatsuro; Yamada, Noboru; Iwai, Kazuo title: Microorganisms causing pyogenic spondylitis: Comparison of community and hospital-acquired types date: 2012-06-01 words: 1732 flesch: 33 summary: Key words: Classification, infecting microorganism, pyogenic spondylitis, sepsis Introduction Pyogenic spondylitis is a common orthopedic infec- tious disease. Pneumonia is generally clarified into community or hospital- acquired types based on where the infection was acquired, and the infecting microorganisms are different for each type. keywords: cases; hospital; microorganisms; spondylitis; type cache: ujms-5960.pdf plain text: ujms-5960.txt item: #149 of 550 id: ujms-5964 author: Baer, Klaus; Nyström, Bo title: Routine intubation in the prone position date: 2012-05-10 words: 2612 flesch: 53 summary: Brimacombe JR, Wenzel V, Keller C. The ProSeal laryngeal mask airway in prone patients: a retrospective audit of 245 patients. During intubation the following day the extent of exposure of the glottis was graded according to Cormack and Lehane (10) in order to examine and determine what observations were important for the final goal, i.e. the possibility of performing prone tracheal intubation. keywords: intubation; laryngeal; mallampati; patient; position; study; surgery; tracheal cache: ujms-5964.pdf plain text: ujms-5964.txt item: #150 of 550 id: ujms-6079 author: Bergman, Ingrid-Maria title: Toll-like receptors (TLRs) and mannan-binding lectin (MBL): On constant alert in a hostile environment date: 2011-02-17 words: 7685 flesch: 58 summary: HughesAL,Piontkivska H.Functionaldiversification ofthe toll- like receptor gene family. Kabelitz D, Medzhitov R. Innate immunity-cross-talk with adaptive immunity through pattern recognition receptors and cytokines. keywords: adaptive; binding; complement; defense; genes; human; immune; immunity; immunol; innate; lectin; mbl; non; receptors; recognition; selection; self; tlr2; tlrs; toll cache: ujms-6079.pdf plain text: ujms-6079.txt item: #151 of 550 id: ujms-6080 author: Eriksson, Olof; Långström, Bengt; Josephsson, Ray title: Assessment of receptor occupancy-over-time of two dopamine transporter inhibitors by [11C]CIT and target controlled infusion date: 2011-03-28 words: 4217 flesch: 58 summary: The occupancy is consistent with a previous PET study in rhesus monkey, where doses of 3 and 10 mg/kg bupropion 90 minutes later produced DAT occupancies of 53% and 72%, respectively (18). GBR-12909 showed high initial occupancy of 76.1% combined with zero release during the first 60 minutes. keywords: cerebellum; dat; infusion; model; occupancy; reference; state; target; time; tissue; tracer cache: ujms-6080.pdf plain text: ujms-6080.txt item: #152 of 550 id: ujms-6081 author: Kuroda, Tomoya; Matsumoto, Tomoyuki; Mifune, Yutaka; Fukui, Tomoaki; Kubo, Seiji; Matsushita, Takehiko; Asahara, Takayuki; Kurosaka, Masahiro; Kuroda, Ryosuke title: Therapeutic strategy of third-generation autologous chondrocyte implantation for osteoarthritis date: 2011-02-28 words: 4810 flesch: 52 summary: Minas T, Nehrer S. Current concepts in the treatment of articular cartilage defects. Recently, various therapeutic strategies includ- ing bone-marrow stimulation and transplantation of osteochondral autografts or allografts have been devel- oped to restore articular cartilage so as to achieve a permanent repair (3). keywords: aci; articular; cartilage; cells; chondrocytes; ci group; collagen; group; knee; repair; week cache: ujms-6081.pdf plain text: ujms-6081.txt item: #153 of 550 id: ujms-6082 author: Siren, Pontus Max Axel; Siren, Matti Juhani title: Critical diaphragm failure in sudden infant death syndrome date: 2011-01-12 words: 7562 flesch: 59 summary: As such, there is no specific underlying genetic or con- genital vulnerability in SIDS infants, and completely normal infants can die of SIDS. Respiratory muscles: the vital pump. keywords: appl; capacity; cause; cdf; death; diaphragm; failure; fatigue; infant; infections; med; melatonin; muscle; physiol; position; reduction; rem; respiratory; sids; sleep; syndrome cache: ujms-6082.pdf plain text: ujms-6082.txt item: #154 of 550 id: ujms-6083 author: Márton, Sándor; Garai, János; Molnár, Valéria; Juhász, Vera; Bogár, Lajos; Köszegi, Tamás; Falusi, Boglárka; Ghosh, Subhamay title: Kinetics of inflammatory markers following cancer-related bowel and liver resection date: 2010-11-23 words: 3278 flesch: 50 summary: Higher elevations in MIF levels with liver resections, compared to bowel resections, might be attributable to MIF release from damaged liver cells. In our prospective, descriptive clinical study we investigated the changes of MIF levels and other indicators of systemic inflammation in patients under- going bowel resection with presumably higher endo- toxin levels (14,15), compared with patients having hepatic resection without enterotomy. keywords: factor; groups; levels; macrophage; mif; migration; patients; resection; tnf cache: ujms-6083.pdf plain text: ujms-6083.txt item: #155 of 550 id: ujms-6084 author: Koakutsu, Tomoaki; Nakajo, Junko; Morozumi, Naoki; Hoshikawa, Takeshi; Ogawa, Shinji; Ishii, Yushin title: Cervical myelopathy due to degenerative spondylolisthesis date: 2011-02-18 words: 2034 flesch: 55 summary: The number of reports on cervical spondylotic myelopathy due to DSL has not been low (3–7), but no general consensus has been reached on the onset mechanism of spinal cord compression. In all patients in the DSL group, myelography and CTM did not show spinal cord compression in the flexion position where SAC was minimum, but in the exten- sion position where SAC was maximum, spinal cord compression caused by the protruded disc and the ligamentum flavum was confirmed. keywords: cervical; dsl; position; spinal cache: ujms-6084.pdf plain text: ujms-6084.txt item: #156 of 550 id: ujms-6085 author: Koakutsu, Tomoaki; Morozumi, Naoki; Koizumi, Yutaka; Ishii, Yushin title: Lumbar radiculopathy caused by foraminal stenosis in rheumatoid arthritis date: 2010-11-24 words: 2699 flesch: 52 summary: We assumed that the pathogenesis of foraminal stenosis in the lumbar spine of RA patients is the compression of the nerve root by the superior articular process of the lower vertebra; this is caused by vertical instability of the facet joint when facet joint lesions are associated with disorders in the vertebral body and the intervertebral disc. With regard to surgical treatment, Crawford et al. stated that RA patients who undergo an instrumented lumbar fusion can expect a slightly higher complica- tion rate than patients without RA, which may be related to osteopenia and immunosuppression (3). keywords: lesions; lumbar; nerve; patients; rheumatoid; stenosis cache: ujms-6085.pdf plain text: ujms-6085.txt item: #157 of 550 id: ujms-6086 author: Mohammadzadeh, Ali ; Haghighi, Mohammad ; Naderi, Bahram ; Chaudhry, Amanullah ; Hussain Khan, Zahid ; Rasouli, Mohammad R.; Saadat, Soheil title: Comparison of two different methods of fiber-optic nasal intubation: conventional method versus facilitated method (NASAL-18) date: 2011-02-15 words: 2803 flesch: 58 summary: The patients were randomly allocated into two groups of nasal intubation using either the NASAL-18 or the conventional method (control) based on a table of randomization. Nasal intubation with a spiral tube #7 followed. keywords: fiber; fiberscope; groups; intubation; nasal; optic; tube cache: ujms-6086.pdf plain text: ujms-6086.txt item: #158 of 550 id: ujms-6087 author: Koike, Yoichi; Sano, Hirotaka; Kinjyo, Takeshi; Imamura, Itaru; Masahiro, Onuma; Goto, Masako; Ooyama, Masamizu; Kita, Atushi; Itoi, Eiji title: Shoulder surface temperature and bone scintigraphy findings in patients with rotator cuff tears date: 2011-02-16 words: 3386 flesch: 63 summary: For measurements of shoulder surface temperature, a Thermochron was attached to both shoulders. RI uptake is increased in shoulders with rotator cuff tears, whereas shoulder surface temperature shows no differences on the affected and unaffected sides. keywords: bone; cuff; joint; patients; rotator; shoulder; surface; temperature; uptake cache: ujms-6087.pdf plain text: ujms-6087.txt item: #159 of 550 id: ujms-6088 author: Lampon, Natalia ; Tutor, J. Carlos title: A preliminary investigation on the possible association between diminished copper availability and non-alcoholic fatty liver disease in epileptic patients treated with valproic acid date: 2010-12-29 words: 4820 flesch: 58 summary: A relevant proportion of non-alcoholic fatty liver disease patients had low copper stores (12,13), which is associated with more pronounced insulin resistance and other clinical features of the metabolic syndrome, and might be a typical feature of pathophysiological relevance to its hepatic manifestation as non-alcoholic fatty liver disease (12,13). VOL_116_002_SUPS_A_545898 148..154 Upsala Journal of Medical Sciences. 2011; 116: 148–154 ORIGINAL ARTICLE A preliminary investigation on the possible association between diminished copper availability and non-alcoholic fatty liver disease in epileptic patients treated with valproic acid NATALIA LAMPON & J. CARLOS TUTOR Unidad Monitorización Fármacos, Laboratorio Central, Hospital Clínico Universitario, Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain Abstract Background. keywords: activity; ceruloplasmin; copper; disease; fatty; liver; oxidase; patients; platelet; vpa cache: ujms-6088.pdf plain text: ujms-6088.txt item: #160 of 550 id: ujms-6089 author: Lin, Hung-Yuan ; Lai, Jiun-I ; Lai, Yi-Chun ; Lin, Po-Chou ; Chang, Shih-Chieh ; Tang, Gau-Jun title: Acute renal failure in severe pancreatitis: A population-based study date: 2011-01-20 words: 3170 flesch: 56 summary: The presence of acute renal failure is associated with increased mortality in ICU patients admitted due to acute pancreatitis We assessed whether AP coexisting with ARF was associated with increased mortality. Risk of acute renal failure in non-pancreatitis patients with separate diagnoses compared to pancreatitis patients. keywords: acute; arf; failure; icu; mortality; pancreatitis; patients; study cache: ujms-6089.pdf plain text: ujms-6089.txt item: #161 of 550 id: ujms-6091 author: Carlsson, Per-Ola title: Influence of microenvironment on engraftment of transplanted β-cells date: 2011-02-02 words: 5177 flesch: 48 summary: Experimental studies indicate that approximately 70% of the islets are hypoxic 1 day after intraportal transplantation, as evaluated by the biochemical marker pimonidazole which accumulates in islet cells at oxygen tension levels below 7.5–10 mmHg (14). Moreover, late dysfunction and death contribute to the poor long-term results of islet transplantation on insulin independence. keywords: blood; carlsson; cell; diabetes; function; implantation; islet transplantation; islets; liver; microenvironment; site; transplantation; transplanted cache: ujms-6091.pdf plain text: ujms-6091.txt item: #162 of 550 id: ujms-6092 author: Rasmusson Duprez, Ida; Johansson, Ulrika; Nilsson, Bo; Korsgren, Olle; Magnusson, Peetra U. title: Preparatory studies of composite mesenchymal stem cell islets for application in intraportal islet transplantation date: 2010-11-04 words: 5813 flesch: 57 summary: Furthermore, MSCs suppressed lymphocyte proliferation induced by islet cells in MLIR. Conclusion. MSCs and islet cells in mixed lymphocyte–islet reactions (MLIR) keywords: blood; bone; cells; coating; composite; control; figure; human; insulin; islets; marrow; mesenchymal; mscs; proliferation; stem; surface; transplantation cache: ujms-6092.pdf plain text: ujms-6092.txt item: #163 of 550 id: ujms-6095 author: Abdulla, Mohammed H. ; Sattar, Munavvar A. ; Abdullah, Nor A. ; Khan, Abdul Hye ; Anand Swarup, Kolla R. L. ; Rathore, Hassaan A. ; Kazi, Raisa N. ; Basri, Fathihah ; Johns, Edward J. title: Effect of renal sympathetic nerve on adrenergically and angiotensin II-induced renal vasoconstriction in normal Wistar-Kyoto rats date: 2010-11-04 words: 4782 flesch: 60 summary: All data were expressed as mean % reduction ± SEM of renal vasoconstrictor responses elicited by all the doses of Ang II, NA, and ME, and compared between CT, DNX, L, DNX-L, CV, DNX-CV, LCV, and DNX-LCV-treated WKY rats. Finally, CT, DNX-L, and DNX-LCV rats had lower over- all mean renal vasoconstrictor responses to NA compared to DNX (CT 32.2% ± 3.0%, DNX-L 32.7% ± 2.4%, and DNX-LCV 16.2% ± 1.5% versus DNX 39.0% ± 4.0%; all P < 0.05) (Figure 2). keywords: ang; angiotensin; dnx; lcv; rats; renal; responses; vasoconstrictor cache: ujms-6095.pdf plain text: ujms-6095.txt item: #164 of 550 id: ujms-6096 author: Nilsson, Ulf R.; Funke, Lillemor; Nilsson, Bo ; Ekdahl, Kristina N. title: Two conformational forms of target-bound iC3b that distinctively bind complement receptors 1 and 2 and two specific monoclonal antibodies date: 2010-11-11 words: 4747 flesch: 60 summary: Factor I-mediated cleavage of bound C3 fragments with CR1 as co-factor. Bound C3 was detected using pAbs anti-C3d (filled triangles) and anti-C3c (open triangles), and mAbs 7D323.1 (squares), 7D18.1 (circles), 7D264.6 (open diamonds), and 7D84.1 (filled diamonds). keywords: anti; binding; complement; cr1; cr2; fragments; human; ic3b; mabs; serum cache: ujms-6096.pdf plain text: ujms-6096.txt item: #165 of 550 id: ujms-6097 author: Mindemark, Mirja; Larsson, Anders title: Longitudinal trends in laboratory test utilization at a large tertiary care university hospital in Sweden date: 2010-11-11 words: 3458 flesch: 64 summary: SUPS_A_528071 34..38 Upsala Journal of Medical Sciences. 2011; 116: 34–38 ORIGINAL ARTICLE Longitudinal trends in laboratory test utilization at a large tertiary care university hospital in Sweden MIRJA MINDEMARK & ANDERS LARSSON Department of Medical Sciences, Section of Clinical Chemistry, Uppsala University, Uppsala, Sweden Abstract Background. The aim of the study was to describe and evaluate longitudinal trends in laboratory test utilization over a 7-year period from 2002 to 2008. keywords: laboratory; number; period; results; study; test; total; utilization cache: ujms-6097.pdf plain text: ujms-6097.txt item: #166 of 550 id: ujms-6098 author: Lipcsey, Miklós ; Furebring, Mia; Rubertsson, Sten; Larsson, Anders title: Significant differences when using creatinine, modification of diet in renal disease, or cystatin C for estimating glomerular filtration rate in ICU patients date: 2010-11-11 words: 4587 flesch: 62 summary: SUPS_A_526724 39..46 Upsala Journal of Medical Sciences. 2011; 116: 39–46 ORIGINAL ARTICLE Significant differences when using creatinine, modification of diet in renal disease, or cystatin C for estimating glomerular filtration rate in ICU patients MIKLÓS LIPCSEY1, MIA FUREBRING2, STEN RUBERTSSON1 & ANDERS LARSSON3 1Section of Anaesthesiology & Critical Care, Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden, 2Section of Infectious Diseases, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden, and 3Section of Clinical Chemistry, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden Abstract Background. A recent meta-analysis has shown that cystatin C is superior to plasma creatinine as a marker of renal function (15). keywords: care; creatinine; cystatin; gfr; min/1.73; patients; plasma; renal; results cache: ujms-6098.pdf plain text: ujms-6098.txt item: #167 of 550 id: ujms-6099 author: Marcos, Bernardino; Bouzas, Lorena; Tutor, J. Carlos title: A limited sampling strategy for estimation of the area under the curve (0 to 8 hours) of mycophenolic acid administered three times daily to liver transplant recipients date: 2010-11-01 words: 3110 flesch: 60 summary: Results The generally considered therapeutic window for MPA AUC(0–12h) is 30–60 mg.h/mL (10,11), and consequently, for the maintenance of an analogous daily drug exposure (cumulative 24 hours AUC), a tentative therapeutic interval for MPA AUC(0–8h) of around 20–40 mg.h/mL may be proposed. In 22 liver transplant patients who were administered MPA three times daily, the trapezoidal extrapolated MPA AUC(0–8h) values using a sampling time from 0 to 2 hours were calculated. Results. keywords: auc(0–8h; liver; mg.h; mpa; transplant; transplantation cache: ujms-6099.pdf plain text: ujms-6099.txt item: #168 of 550 id: ujms-6100 author: Kesek, Milos; Rönn, Folke; Tollefsen, Titti; Höglund, Niklas; Näslund, Ulf; Jensen, Steen M. title: Symptomatic improvement after catheter ablation of supraventricular tachycardia measured by the arrhythmia-specific questionnaire U22 date: 2010-11-16 words: 4861 flesch: 62 summary: The questionnaire U22 quantifies symptoms associated with arrhythmic events. Key words: Arrhythmia symptoms, catheter ablation, quality of life, supraventricular tachycardia, symptom-specific protocol Introduction The main indication for ablation of supraventricular tachycardia (SVTA) is symptomatic relief (1). keywords: ablation; arrhythmia; follow; line; patients; sf-36; symptoms; u22 cache: ujms-6100.pdf plain text: ujms-6100.txt item: #169 of 550 id: ujms-6101 author: Rask-Andersen, Anna title: Asthma increase among farmers: a 12-year follow-up date: 2010-09-03 words: 8838 flesch: 63 summary: In an analysis of data from the European Commu- nity Respiratory Health Survey (ECRHS) in ten European countries as well as USA and New Zealand, the highest risk of asthma (defined as bronchial hyper- responsiveness and reported asthma symptoms or medication) attributed to occupation was found for farmers, OR 2.62 (95% CI 1.29–5.35) (28). Farmers who were still farming and were exposed to farm dust had a trend to lower FEV1 (79% of predicted) compared to farmers who had quit farming (91% predicted), although this difference was not signifi- cant. keywords: age; allergy; asthma; bronchitis; cases; dust; exposure; farmers; farming; ige; non; population; prevalence; risk; study; symptoms; tests; work; years cache: ujms-6101.pdf plain text: ujms-6101.txt item: #170 of 550 id: ujms-6102 author: Bulbul, Yilmaz; Ayik, Sibel; Oztuna, Funda; Ozlu, Tevfik; Sahin, Sibel title: The relationship between socio-demographic characteristics of patients and diagnostic delay in acute pulmonary thromboembolism date: 2010-11-11 words: 3000 flesch: 60 summary: However, total delay and patient delay were not significantly different between patients who died and those who survived. Mean time from symptoms to the first admission to a health institution (patient delay) was 2.04 ± 3.89 days (median 0 day, range 0–30). keywords: days; delay; diagnosis; health; patients; symptoms cache: ujms-6102.pdf plain text: ujms-6102.txt item: #171 of 550 id: ujms-6103 author: Lai, Yi-Chun ; Teng, Chung-Jen ; Chen, Paul Chih-Hsueh ; Chiou, Tzeon-Jye ; Liu, Chun-Yu title: Unusual scalp crusted scabies in an adult T-cell leukemia/lymphoma patient date: 2011-01-17 words: 1042 flesch: 54 summary: HTLV-1-induced immunosuppression has been linked to the occur- rence of crusted scabies in HTLV-1 carriers and in ATL patients (8). Although ATL-associated skin lesions are common in ATL patients, crusted scabies should also be considered in the differential diagnosis of either localized or generalized cutaneous eruptions in patients with ATL. Declaration of interest: The authors report no conflicts of interest. keywords: atl; cell; medicine; scabies cache: ujms-6103.pdf plain text: ujms-6103.txt item: #172 of 550 id: ujms-6104 author: Karlsson, Torbjörn title: Anders Fredrik Regnell – an early and generous sponsor of our society date: 2011-02-14 words: 649 flesch: 63 summary: Anders Fredrik Regnell became a student in Uppsala 1824, passed the preparatory exams for medical studies 1830, med lic 1836 and got his medical doctorate as primus 1837. Anders Fredrik Regnell deserves to be remembered also because of his monetary contributions to research and education. keywords: anders; fredrik cache: ujms-6104.pdf plain text: ujms-6104.txt item: #173 of 550 id: ujms-6105 author: Karlsson, Torbjörn ; Rask-Andersen, Anna title: Member Announcements date: 2011-02-14 words: 359 flesch: 64 summary: This event is a joint project between Selanderska stiftelsen, Uppsala Medicinhistoriska förening, Uppsala Medicinska Seniorer and the Upsala Medical Society. It will all take place on April 5 (for further details, see separate announcement and our web page). keywords: society; time cache: ujms-6105.pdf plain text: ujms-6105.txt item: #174 of 550 id: ujms-6113 author: Lampon, Natalia; Tutor, J. Carlos title: Apparent clearance of valproic acid in elderly epileptic patients: estimation of the confounding effect of albumin concentration date: 2011-12-29 words: 4478 flesch: 55 summary: Total VPA concentrations should be interpreted with caution, mainly in older patients, in which determination of unbound or normalized total drug concentrations may be clinically useful. At present, the clinical usefulness of measurements of VPA unbound concentrations is a debated subject (19,23); however, decreases in VPA protein binding are followed by reductions in total serum concentra- tions, whereas unbound concentrations are unchanged, and these reduced total concentrations may be misinterpreted as reflecting an inadequate dosage (24). keywords: acid; albumin; apparent; concentrations; css; cssn; drug; patients; serum; valproic; vpa cache: ujms-6113.pdf plain text: ujms-6113.txt item: #175 of 550 id: ujms-6117 author: Andersson, Anne; Melin, Beatrice ; Enblad, Gunilla; Erlanson, Martin; Johansson, Ann-Sofie; Molin, Daniel; Tavelin, Björn; Näslund, Ulf title: High risk of cardiovascular side effects after treatment of Hodgkin’s lymphoma – is there a need for intervention in long-term survivors? date: 2021-03-15 words: 5381 flesch: 58 summary: Swerdlow AJ, Barber JA, Hudson GV, Cunningham D, Gupta RK, Hancock BW, et al. Risk of second malignancy after Hodgkin’s disease in a col- laborative British cohort: the relation to age at treatment. van Nimwegen FA, Ntentas G, Darby SC, Schaapveld M, Hauptmann M, Lugtenburg PJ, et al. Risk of heart failure in survivors of Hodgkin lym- phoma: effects of cardiac exposure to radiation and anthracyclines. keywords: cvd; disease; hodgkin; individuals; patients; radiotherapy; risk; study; survivors; treatment; years cache: ujms-6117.pdf plain text: ujms-6117.txt item: #176 of 550 id: ujms-6124 author: SALCI, KONSTANTIN ; ENBLAD, PER ; GOINY, MICHEL ; CONTANT, CHARLES F. ; PIPER, IAN ; NILSSON, PELLE title: Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat date: 2010-10-27 words: 5769 flesch: 63 summary: 221–231 ORIGINAL ARTICLE Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat KONSTANTIN SALCI1, PER ENBLAD1, MICHEL GOINY2, CHARLES F. CONTANT3, IAN PIPER4 & PELLE NILSSON1 1Department of Neurosurgery, Uppsala University Hospital, Uppsala, Sweden, 2Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden, 3Department of Neurosurgery, Baylor College of Medicine, Houston, USA, and 4Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK Abstract Introduction. Traumatic brain injury makes the brain vulnerable to secondary insults. keywords: blood; brain; groups; hypotension; icp; impact; injury; insult; intracranial; period; post; time; trauma cache: ujms-6124.pdf plain text: ujms-6124.txt item: #177 of 550 id: ujms-6126 author: VÆGTER, KELD ; WAHLSTRÖM, ROLF ; WEDEL, HANS ; SVÄRDSUDD, KURT title: Effect of mailed feedback on drug prescribing profiles in general practice: a seven-year longitudinal study in Storstrøm County, Denmark date: 2010-10-07 words: 4422 flesch: 57 summary: Whether written feedback on drug prescribing in general practice affects prescribing habits is controversial. Key words: Drug prescribing, general practice, mailed feedback Introduction Drug prescribing in general practice is subject to attention from all interested parties. keywords: county; data; drug; feedback; gps; group; habits; health; practices; prescribing; study cache: ujms-6126.pdf plain text: ujms-6126.txt item: #178 of 550 id: ujms-6268 author: Hovatta, Outi title: Who benefits from putting family life into ice? date: 2016-10-19 words: 2329 flesch: 62 summary: In a study among single women seeking treatment with the use of donated sperm, 91% stated that they would have preferred to have the child together with a partner, and 66% had been in a relationship where they desired to have a child. Salomon M, Sylvest R, Hansson H, Nyboe Andersen A, Schmidt L. Sociodemographic characteristics and attitudes towards mother- hood among single women compared with cohabiting women treated with donor semen – a Danish multicenter study. keywords: age; eggs; fertility; freezing; oocytes; reprod; vitrification; women cache: ujms-6268.pdf plain text: ujms-6268.txt item: #179 of 550 id: ujms-6269 author: St. Fleur, Michelle ; Damus, Karla ; Jack, Brian title: The future of preconception care in the United States: multigenerational impact on reproductive outcomes date: 2016-07-19 words: 4570 flesch: 56 summary: (31) posits that dispar- ities in birth outcomes are the consequences of differential developmental trajectories that are set by early life experien- ces and cumulative allostatic load over the life course (31). Additional human data that lend support to the theory that stressful events can impact birth outcomes in subse- quent generations are provided in studies by Collins known as the Grandmother Epidemiologic data set (37) that links UPSALA JOURNAL OF MEDICAL SCIENCES 213 keywords: birth; care; childhood; disparities; events; health; life; outcomes; preconception; preterm; racial; stress; women cache: ujms-6269.pdf plain text: ujms-6269.txt item: #180 of 550 id: ujms-6270 author: Berglund, Anna ; Lindmark, Gunilla title: Preconception health and care (PHC)—a strategy for improved maternal and child health date: 2016-06-20 words: 5381 flesch: 47 summary: The present article gives an over- view of the recent literature and important issues in the con- tents and delivery of health care prior to pregnancy in Western as well as low-income countries. Fragmentation of health care is a problem for many patient groups, but especially when interventions that need the participation of several professionals or a change in life perspective. keywords: care; counselling; family; health; maternal; partner; phc; preconception; pregnancy; programmes; violence; women cache: ujms-6270.pdf plain text: ujms-6270.txt item: #181 of 550 id: ujms-6271 author: Verbiest, Sarah ; McClain, Erin ; Woodward, Suzanne title: Advancing preconception health in the United States: strategies for change date: 2016-09-20 words: 3746 flesch: 28 summary: Show Your Love’s website objectives include: (1) enabling young adults to manage their personal and family well-being by making realistic health and lifestyle improvements daily; (2) educating young adults and their loved ones about tools and resources available to support healthy lifestyles; and (3) bridging the gap in access to and communication between young adults and their health care provider by helping them understand critical components about preconception health care, life planning, and health insurance (including pre- and post-doc- tor dialogues, information about access to care) and (4) empowering young adults to become health advocates in their communities by getting involved with Show Your Love. This manuscript describes the reasons why the US needs to priori- tize preconception health as well as its efforts historically to advance change. keywords: adults; care; health; initiative; national; planning; preconception; preconception health; reproductive; resources; strategies; women cache: ujms-6271.pdf plain text: ujms-6271.txt item: #182 of 550 id: ujms-6275 author: Kopp Kallner, Helena ; Gemzell Danielsson, Kristina title: Prevention of unintended pregnancy and use of contraception—important factors for preconception care date: 2016-09-20 words: 3547 flesch: 53 summary: Ectopic pregnancy due to a planned pregnancy may be considered as inevitable, but ectopic pregnancies may also be due to an unintended pregnancy. Risks of unintended pregnancies do not only include risk of abortion and abortion-related complications but also risk of ectopic pregnancy, which may reduce future fertility, and risk of molar pregnancy that may lead to malig- nancy. keywords: anemia; contraception; endometriosis; gynecol; health; methods; pregnancies; pregnancy; risk; use; women cache: ujms-6275.pdf plain text: ujms-6275.txt item: #183 of 550 id: ujms-6276 author: Ojukwu, Obiamaka ; Patel, Dilisha ; Stephenson, Judith ; Howden, Beth ; Shawe, Jill title: General practitioners’ knowledge, attitudes and views of providing preconception care: a qualitative investigation date: 2016-09-20 words: 7711 flesch: 58 summary: TF-IUPS160040 256..263 ORIGINAL ARTICLE General practitioners’ knowledge, attitudes and views of providing preconception care: a qualitative investigation Obiamaka Ojukwua, Dilisha Patela, Judith Stephensona, Beth Howdenb and Jill Shawec aInstitute for Women’s Health, University College London, London, United Kingdom; bUniversity of Bristol, Bristol, United Kingdom; cFaculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom ABSTRACT Background: Preconception health and care aims to reduce parental risk factors before pregnancy through health promotion and intervention. Methods: As part of a large mixed-methods study to explore preconception care in England, we sur- veyed 1,173 women attending maternity units and GP services in London and interviewed women and health professionals. keywords: advice; care; child; general; gps; guidelines; health; knowledge; preconception; preconception care; preconception health; pregnancy; qualitative; study; women cache: ujms-6276.pdf plain text: ujms-6276.txt item: #184 of 550 id: ujms-6277 author: Delbaere, Ilse ; Mokangi, Pascale ; De Sutter, An ; Gellynck, Xavier ; Beeckman, Dimitri ; van de Walle, Liselot ; Vandenbulcke, Pieter ; De Steur, Hans title: Systematic development of an evidence-based website on preconception care date: 2016-09-01 words: 4476 flesch: 45 summary: People got to the website by searching on a variety of terms, such as ‘becoming pregnant’, ‘folic acid’, ‘healthy pregnancy’, ‘cycle’, and a combination of food products and ‘pregnancy’; 15% of visitors came via links from other websites. Channel Percentage of users Organic search 70.5% Referral (by other websites) 14.7% Direct entry 14.2% Social media 0.6% UPSALA JOURNAL OF MEDICAL SCIENCES 269 http://www.itg.be http://steunpuntwvg.be/images/swvg-1-publicaties/2011_06-r17-jong-gezondheid-eerste-levensweken http://steunpuntwvg.be/images/swvg-1-publicaties/2011_06-r17-jong-gezondheid-eerste-levensweken http://steunpuntwvg.be/images/swvg-1-publicaties/2011_06-r17-jong-gezondheid-eerste-levensweken http://docs.vlaamsparlement.be/docs/stukken/2009-2010/g462-1.pdf http://docs.vlaamsparlement.be/docs/stukken/2009-2010/g462-1.pdf http://www.domusmedica.be/documentatie/downloads/praktijkdocumenten/richtlijnen/730-preconceptieadvies-1/file.html http://www.domusmedica.be/documentatie/downloads/praktijkdocumenten/richtlijnen/730-preconceptieadvies-1/file.html http://www.domusmedica.be/documentatie/downloads/praktijkdocumenten/richtlijnen/730-preconceptieadvies-1/file.html https://kce.fgov.be/publication/report/what-are-the-recommended-clinical-assessment-and-screening-tests-during-pregnancy#.V01u2fmLTGw recommended-clinical-assessment-and-screening-tests-during-preg- nancy#.V01u2fmLTGw. keywords: acid; care; experts; folic; guidelines; health; information; preconception; public; visitors; website; women cache: ujms-6277.pdf plain text: ujms-6277.txt item: #185 of 550 id: ujms-6278 author: Becker, Wulf ; Lindroos, Anna Karin ; Nälsén, Cecilia ; Warensjö Lemming, Eva ; Öhrvik, Veronica title: Dietary habits, nutrient intake and biomarkers for folate, vitamin D, iodine and iron status among women of childbearing age in Sweden date: 2016-08-25 words: 4185 flesch: 61 summary: Sj€oberg and Hulth�en (17) compared food habits, iron intake, and status in two cross-sectional studies among 15–16-year-old girls and boys, sampled from schools in Gothenburg, before (1994, n¼1245) and after (2000, n¼1020) discontinuation of the fortification. Thus, a general increase in iodine intake is desir- able, especially important for women of childbearing age. keywords: age; folate; food; intake; iodine; iron; status; vitamin; women cache: ujms-6278.pdf plain text: ujms-6278.txt item: #186 of 550 id: ujms-6279 author: Sylvest, Randi ; Krogh Fürbringer, Jeanette ; Schmidt, Lone ; Pinborg, Anja title: Infertile men’s needs and assessment of fertility care date: 2016-08-08 words: 6311 flesch: 67 summary: Men as patients: understanding and communicating with men. The interview items were con- structed in accordance with the experience and knowledge of the researchers and on the basis of previous studies about infertile couples and infertile men (3,4,7,8,10,11). keywords: care; clinic; fertility; information; interview; male; men; staff; study; time; treatment cache: ujms-6279.pdf plain text: ujms-6279.txt item: #187 of 550 id: ujms-6280 author: Hoeg, Didde ; Schmidt, Lone ; Macklon, Kirsten T. title: Young female cancer patients’ experiences with fertility counselling and fertility preservation—a qualitative small-scale study within the Danish health care setting date: 2016-07-14 words: 4964 flesch: 56 summary: A quan- titative Dutch study argues that more attention should be paid to improve fertility preservation counselling, so that the women understand what fertility preservation involves and feel supported in their decision-making process (19). The partici- pants described how specialized fertility counselling and fertility preservation contributed to a belief in life after cancer, which gave them hope that they would survive their cancer disease. keywords: cancer; children; counselling; fertility; fertility counselling; fertility preservation; participants; preservation; study; treatment; women cache: ujms-6280.pdf plain text: ujms-6280.txt item: #188 of 550 id: ujms-6281 author: Ekstrand Ragnar, Maria ; Tydén, Tanja ; Kihlbom, Ulrik ; Larsson, Margareta title: Swedish parents’ interest in preconception genetic carrier screening date: 2016-09-20 words: 4949 flesch: 57 summary: The varying associations to PCS interest are not easily explained, but prob- ably reflect the diversity in PCS attitudes among the parents in our study. No differences in PCS interest were found between women and men (P ¼ 0.091), but a higher proportion of women were concerned about negative consequen- ces (53% versus 46%, P < 0.003) and were ‘opposed to such a way of child selection’ (31.8% versus 25.2%, P ¼ 0.002). keywords: carrier; child; health; interest; parents; pcs; pregnancy; screening; study; sweden; women cache: ujms-6281.pdf plain text: ujms-6281.txt item: #189 of 550 id: ujms-6282 author: Kihlbom, Ulrik title: Ethical issues in preconception genetic carrier screening date: 2016-07-18 words: 3765 flesch: 55 summary: The most cherished aim of screening programmes within reproductive health care is no doubt enhancement of reproductive autonomy (22–25). The ethical grounds that reasonably justify having these screening criteria rather than others can be summarized as three broad normative ideas: � Justice � Consequences � Autonomy Considerations of justice seem clearly to be behind criter- ion 8, but can also be viewed as the basis of criteria 4 and 5 as effectiveness in health care is important for the capacity to allocate recourses in a fair way. keywords: autonomy; care; health; pcs; preconception; programmes; reproductive; screening; traits cache: ujms-6282.pdf plain text: ujms-6282.txt item: #190 of 550 id: ujms-6283 author: Tydén, Tanja ; Verbiest, Sarah ; Van Achterberg, Theo ; Larsson, Margareta ; Stern, Jenny title: Using the Reproductive Life Plan in contraceptive counselling date: 2016-09-20 words: 4355 flesch: 54 summary: The midwives also suggested that there UPSALA JOURNAL OF MEDICAL SCIENCES 301 was potential for expanding RLP counselling to other arenas and health care professions. Further, professionals’ beliefs need to be addressed to some extent to ensure an open mind towards providing RLP counselling to all visitors of reproductive ages, not just certain groups. keywords: care; counselling; health; life; midwives; planning; reproductive; rlp; sweden; use; women cache: ujms-6283.pdf plain text: ujms-6283.txt item: #191 of 550 id: ujms-6284 author: Jasovský, Dušan ; Littmann, Jasper ; Zorzet, Anna ; Cars, Otto title: Antimicrobial resistance—a threat to the world’s sustainable development date: 2016-07-14 words: 4674 flesch: 43 summary: It is also vital to con- sider and emulate lessons learned from comparable global political initiatives in global health and other areas. Global health estimates: deaths, disabil- ity-adjusted life year (DALYs), years of life lost (YLL) and years lost due to disability (YLD) by cause, age and sex. keywords: access; amr; antibiotics; development; diseases; drug; global; health; health organization; organization; resistance; sdg; world; world health cache: ujms-6284.pdf plain text: ujms-6284.txt item: #192 of 550 id: ujms-6285 author: Högberg, Dominika ; Dellagrammaticas, Demosthenes ; Kragsterman, Björn ; Björck, Martin ; Wanhainen, Anders title: Simplified ultrasound protocol for the exclusion of clinically significant carotid artery stenosis date: 2016-07-05 words: 3699 flesch: 42 summary: Screening for asymptomatic carotid artery stenosis: U.S. Preventive Services Task Force recommendation statement. Endarterectomy for asymptomatic carotid artery stenosis. keywords: artery; carotid; greyscale; ica; method; mosaic; screening; stenosis; study; ultrasound cache: ujms-6285.pdf plain text: ujms-6285.txt item: #193 of 550 id: ujms-6286 author: Tsuchie, Hiroyuki ; Miyakoshi, Naohisa ; Kasukawa, Yuji ; Senma, Seietsu ; Narita, Yuichiro ; Miyamoto, Seiya ; Hatakeyama, Yuji ; Sasaki, Kana ; Shimada, Yoichi title: Factors related to curved femur in elderly Japanese women date: 2016-05-26 words: 3420 flesch: 59 summary: Conclusion: Femoral curvature is strongly influenced by age and serum vitamin D. ARTICLE HISTORY Received 4 November 2015 Revised 28 March 2016 Accepted 27 April 2016 KEYWORDS 25-Hydroxyvitamin D; atypical femoral fracture; curved femur; osteomalacia; women Introduction Although bisphosphonates (BPs) are the gold standard for osteoporosis pharmacotherapy, several adverse effects related to their long-term use have recently been reported, such as osteonecrosis of the jaw (ONJ) and atypical low-energy sub- trochanteric and diaphyseal femoral fractures due to markedly suppressed bone turnover (SSBT) (1,2). We evaluated the influence of factors related to bone metabolism and posture on the development of femoral curvature. keywords: 25(oh)d; bone; curvature; femur; patients cache: ujms-6286.pdf plain text: ujms-6286.txt item: #194 of 550 id: ujms-6287 author: Tonkonogi, Aleksandra ; Carlsson, Axel C. ; Helmersson-Karlqvist, Johanna ; Larsson, Anders ; Ärnlöv, Johan title: Associations between urinary kidney injury biomarkers and cardiovascular mortality risk in elderly men with diabetes date: 2016-06-20 words: 3862 flesch: 49 summary: Associations between urinary kidney injury biomarkers and cardiovascular mortality risk in elderly men with diabetes Introduction Material and methods Medical information Clinical and biochemical analyses Outcome Statistical analysis Results Discussion Acknowledgements Disclosure statement Funding information References TF-IUPS160024 174..178 ORIGINAL ARTICLE Associations between urinary kidney injury biomarkers and cardiovascular mortality risk in elderly men with diabetes Aleksandra Tonkonogia, Axel C. Carlssona,b, Johanna Helmersson-Karlqvistc, Anders Larssonc and Johan €Arnl€ova,d aDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden; bDivision of Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden; cDepartment of Medical Sciences, Biochemical Structure and Function, Uppsala University, Uppsala, Sweden; dSchool of Health and Social Studies, Dalarna University, Falun, Sweden ABSTRACT Aim: Three urinary biomarkers, kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipoca- lin (NGAL), and cystatin C, have been suggested as clinically relevant highly specific biomarkers of acute kidney tubular damage. keywords: biomarkers; damage; diabetes; injury; kidney; kim-1; mortality; nephropathy; risk; study; urinary cache: ujms-6287.pdf plain text: ujms-6287.txt item: #195 of 550 id: ujms-6288 author: Walfridsson, Angelica ; Sehlberg, Maja ; Gillespie, Ulrika ; Dahlkvist, Jonathan ; Johansson, Hans-Erik title: Diabetes treatment and hypoglycaemic episodes in elderly patients at nursing homes in Uppsala County date: 2016-06-30 words: 4158 flesch: 60 summary: UPSALA JOURNAL OF MEDICAL SCIENCES 183 Diabetes treatment and hypoglycaemic episodes in elderly patients at nursing homes in Uppsala County Introduction Subjects and methods Patients and data collection Ethics Statistics Results Discussion Disclosure statement Funding information References HbA1c >73 Number of patients 218 94 78 28 Hypoglycaemia: Patients with no hypoglycaemic events, n (%) 166 (76.1) 82 (87.2)a 54 (69.2) 17 (60.7) Patients with hypoglycaemic events, n (%) 52 (23.9) 12 (12.8)a 24 (30.8) 11 (39.3) Severe hypoglycaemic events: Hypoglycaemia, hospitalization 10 (4.6) 3 (3.2) 2 (2.6) 5 (17.9) Hypoglycaemia, emergency room 8 (3.7) 0 6 (7.7) 1 (3.6) Hypoglycaemia, during hospital care 16 (7.3) 4 (4.3) 6 (7.7) 5 (17.9) Minor hypoglycaemic events: Hypoglycaemia, notes in medical records 33 (15.1) 7 (7.4) 17 (21.8) 8 (28.6) Vascular complications: keywords: complications; diabetes; groups; hba1c; insulin; mmol; patients; treatment cache: ujms-6288.pdf plain text: ujms-6288.txt item: #196 of 550 id: ujms-6289 author: Joelsson, Lana Salih ; Berglund, Anna ; Wånggren, Kjell ; Lood, Mikael ; Rosenblad, Andreas ; Tydén, Tanja title: Do subfertile women adjust their habits when trying to conceive? date: 2016-05-23 words: 6114 flesch: 61 summary: TF-IUPS160018 184..191 ORIGINAL ARTICLE Do subfertile women adjust their habits when trying to conceive? Lana Salih Joelssona,b, Anna Berglundc, Kjell Wånggrena,d, Mikael Loode, Andreas Rosenbladb and Tanja Tyd�enf aDepartment of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden; bCentre for Clinical Research, Uppsala University, County Council of V€astmanland, V€astmanland County Hospital, V€asterås, Sweden; cThe National Centre for Knowledge of Men’s Violence against Women, Uppsala University, Uppsala, Sweden; dDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden; eDepartment of Women’s Health, Fertility Unit, €Orebro University Hospital, €Orebro, Sweden; fDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Effective individual counseling to subfertile women demands an understanding about what measures women take to increase the chances of conception. keywords: alcohol; bmi; changes; health; infertility; information; lifestyle; pregnancy; study; sweden; tobacco; university; use; women; years cache: ujms-6289.pdf plain text: ujms-6289.txt item: #197 of 550 id: ujms-6290 author: Sawicka-Gutaj, Nadia ; Machaczka, Maciej ; Kulińska-Niedziela, Izabela ; Bernardczyk-Meller, Jadwiga ; Gutaj, Paweł ; Sowiński, Jerzy ; Ruchała, Marek title: The appearance of newly identified intraocular lesions in Gaucher disease type 3 despite long-term glucocerebrosidase replacement therapy date: 2016-04-11 words: 2954 flesch: 54 summary: Retinal thinning in Gaucher disease patients and carriers: results of a pilot study. Markuszewska-Kuczy�nska A, Klimkowska M, Regenthal S, Bulanda A, K€ampe Bj€orkvall C, Machaczka M. Atypical cytomorphology of Gaucher cells is frequently seen in bone marrow smears from untreated patients with Gaucher disease type 1. keywords: disease; gaucher; gd3; lesions; patient; poznan; type cache: ujms-6290.pdf plain text: ujms-6290.txt item: #198 of 550 id: ujms-6291 author: Liccardi, Gennaro ; Salzillo, Antonello ; Piccolo, Amedeo ; Calzetta, Luigino ; Rogliani, Paola title: Dysfunction of small airways and prevalence, airway responsiveness and inflammation in asthma: much more than small particle size of pet animal allergens date: 2016-07-11 words: 1115 flesch: 46 summary: TF-IUPS160016 196..197 LETTER TO THE EDITOR Dysfunction of small airways and prevalence, airway responsiveness and inflammation in asthma: much more than small particle size of pet animal allergens Dear Editor, We read with interest the excellent article from Patelis et al. (1) showing that sensitization to small aeroallergens, pro- duced by common pets, was associated with local airway and systemic inflammation, airway responsiveness, and higher prevalence of asthma. Therefore, it is necessary to evaluate the role of exposure to pet allergens related with the risk factors inducing bronchial asthma, which may also involve small airways. keywords: airways; allergens; allergy; asthma; pet cache: ujms-6291.pdf plain text: ujms-6291.txt item: #199 of 550 id: ujms-6292 author: Patelis, Antonios title: Author’s response: Dysfunction of small airways and prevalence, airway responsiveness and inflammation in asthma: much more than small particle size of pet animal allergens date: 2016-07-27 words: 671 flesch: 48 summary: THE EDITOR Author’s response: Dysfunction of small airways and prevalence, airway responsiveness and inflammation in asthma: much more than small particle size of pet animal allergens Dear Editor, We read with interest the letter from Liccardi et al. about our article ‘New data analysis in a population study raises the hypothesis that particle size contributes to the pro-asthmatic potential of small pet animal allergens’ (1). 121, NO. 3, 198 Author&hx2019;s response: Dysfunction of small airways and prevalence, airway responsiveness and inflammation in asthma: much more than small particle size of pet animal allergens Disclosure statement References keywords: allergens; inflammation; study cache: ujms-6292.pdf plain text: ujms-6292.txt item: #200 of 550 id: ujms-6293 author: Siren, Pontus M. A. title: SIDS-CDF hypothesis revisited: explaining hypoxia in SIDS date: 2016-05-12 words: 2651 flesch: 55 summary: Even if more accurate bio- markers can be established, the real challenge is not showing that SIDS victims suffer from hypoxia (this has already been established), but rather developing a model to test if a ‘weak- ened diaphragm–hypoxia–weakened diaphragm’ feedback loop can be caused by a combination of SIDS risk factors (infections, prone sleeping position, REM sleep, prematurity, absence of breastfeeding, cigarette smoke, altitude, etc.) Fortunately, the diaphragm has been extensively investi- gated outside SIDS research, and its dysfunctions and UPSALA JOURNAL OF MEDICAL SCIENCES, 2016 VOL. keywords: death; diaphragm; failure; hypoxia; infant; muscle; sids; syndrome cache: ujms-6293.pdf plain text: ujms-6293.txt item: #201 of 550 id: ujms-6294 author: Francis, Taylor & title: Apology on behalf of the publisher date: 2016-07-08 words: 174 flesch: 55 summary: Published by Informa UK Limited, trading as Taylor & Francis Group. � 2016 Informa Plc Limited. keywords: issue cache: ujms-6294.pdf plain text: ujms-6294.txt item: #202 of 550 id: ujms-6295 author: Andersson , Arne title: Remembering Claes Hellerström and those around him date: 2016-05-16 words: 722 flesch: 65 summary: L-R: Arne Andersson, Dave Sutherland and Claes Hellerstr€om Dave Sutherland, an outstanding pioneer in islet transplantation reseach, before the 1990 Kroc lecture, with Arne Andersson and Claes Hellerstr€om. � 2016 Informa UK Limited, trading as Taylor & Francis Group. TF-IUPS160012 71..72 EDITORIAL Remembering Claes Hellerstr€om and those around him Andersson Arne Editor of Upsala Journal of Medical Sciences I can still remember that early morning in May. keywords: claes; journal; years cache: ujms-6295.pdf plain text: ujms-6295.txt item: #203 of 550 id: ujms-6296 author: Asplund, Kjell title: From phylogeny into ontogeny with Claes Hellerström date: 2016-03-23 words: 3502 flesch: 60 summary: The A1 cell enigma Silver-positive A1 cells were found to be relatively uncommon in mammals; beta cells outnumbered other islet cell types by far. If he could find a species where A1 cells were particularly com- mon, he could get a glimpse of what was the function of these mysterious cells. keywords: cells; claes; hellerstr€om; hellman; islets; pancreas; snakes; studies cache: ujms-6296.pdf plain text: ujms-6296.txt item: #204 of 550 id: ujms-6297 author: Welsh, Michael title: Claes Hellerström and Cartesian diver microrespirometry date: 2015-11-19 words: 3097 flesch: 54 summary: This appar- ent peculiarity of beta cell glucose metabolism seems to have several metabolic explanations but nevertheless is of paramount importance for understanding the coupling between glucose metabolism and exocytosis. Other metabolic substrates found to increase islet oxygen consumption were citrate, oxaloace- tate, D-mannose, D-fructose, L-leucine, 2-ketoisocaproic acid, and 2-aminonorbornane-2-carboxylic acid (BCH) (11–19). keywords: beta; cartesian; cell; consumption; container; diver; glucose; insulin; metabolism; oxygen cache: ujms-6297.pdf plain text: ujms-6297.txt item: #205 of 550 id: ujms-6298 author: Jansson, Leif ; Barbu, Andreea ; Bodin, Birgitta ; Drott, Carl Johan ; Espes, Daniel ; Gao, Xiang ; Grapensparr, Liza ; Källskog, Örjan ; Lau, Joey ; Liljebäck, Hanna ; Palm, Fredrik ; Quach, My ; Sandberg, Monica ; Strömberg, Victoria ; Ullsten, Sara ; Carlsson, Per-Ola title: Pancreatic islet blood flow and its measurement date: 2016-04-28 words: 14919 flesch: 59 summary: Islet blood flow is normally very high compared with that to the exocrine pancreas and is autonomously regulated through com- plex interactions between the nervous system, metabolites from insulin secreting b-cells, endothelium- derived mediators, and hormones. In humans there are still no methods to measure islet blood flow selectively, but new developments in radiological techniques hold great hopes for the future. keywords: arterioles; blood cells; blood flow; blood perfusion; capillaries; carlsson; cells; diabetes; distribution; endocrine; exocrine; insulin; islet; islet blood; jansson; measurements; microspheres; number; organ; pancreas; pancreatic; perfusion; physiol; rats; regulation; studies; techniques; tissue; vascular cache: ujms-6298.pdf plain text: ujms-6298.txt item: #206 of 550 id: ujms-6299 author: Eriksson, Ulf J. ; Wentzel, Parri title: The status of diabetic embryopathy date: 2016-04-27 words: 15986 flesch: 51 summary: Measurements in day-12 embryos, however, indicated a decreased arachidonic acid concentration in the offspring of diabetic rats (136). For instance, increased lipid peroxidation and ROS generation were found in diabetic rats, measured as increased serum 8- epi-PGF2a levels (155) and increased electron spin clearance rate (156). keywords: acid; activity; apoptosis; arachidonic; cell; congenital; culture; defects; development; diabetes; diabetic; effects; embryonic; embryopathy; embryos; eriksson; expression; gene; glucose; high; hyperglycemia; insulin; levels; malformations; maternal; metabolism; mice; mouse; neural; offspring; oxidative; pregnancy; rat embryos; rats; reprod; role; ros; stress; study; type; vitro; wentzel cache: ujms-6299.pdf plain text: ujms-6299.txt item: #207 of 550 id: ujms-6302 author: Briant, Linford ; Salehi, Albert ; Vergari, Elisa ; Zhang, Quan ; Rorsman, Patrik title: Glucagon secretion from pancreatic α-cells date: 2016-04-04 words: 6279 flesch: 49 summary: The argument that paracrine factors influence glucagon secretion is supported by reports that isolated a-cells (that no longer have paracrine input) are unable to respond appropriately (i.e. decreasing their activity and glucagon secretion) to increased glucose concentrations; in fact, the reports demonstrate that glucose stimulates glucagon secretion when a-cells are removed from their normal paracrine environment (23,24). A computational systems analysis of factors regulating alpha cell glucagon secretion. keywords: activity; alpha; cells; channels; diabetes; glucagon; glucagon secretion; glucose; insulin; katp; membrane; paracrine; regulation; release; secretion; sst; type cache: ujms-6302.pdf plain text: ujms-6302.txt item: #208 of 550 id: ujms-6400 author: Eggertsen, Robert ; Mellström, Dan title: Height Loss in Women Caused by Vertebral Fractures and Osteoporosis date: 2009-07-12 words: 2980 flesch: 61 summary: UJMS 02-07.pdf Height loss in women caused by vertebral fractures and osteoporosis 213 Received 1 December 2006 Accepted 12 February 2007 Upsala J Med Sci 112 (2): 213–219, 2007 Height Loss in Women Caused by Vertebral Fractures and Osteoporosis Robert Eggertsen1, Dan Mellström2 1Centre of Bone Research at the Sahlgrenska Academy Department of Medicine/Primary Health Care and Mölnlycke Primary Health Care and Research Centre, 2Department of Medicine/Geriatrics. Göteborg University, Sweden Abstract Background: To investigate women, with height loss of more than three cm, without earlier diagnosed spinal fractures, for osteoporosis and vertebral fractures. keywords: body; fractures; height; hip; loss; osteoporosis; women cache: ujms-6400.pdf plain text: ujms-6400.txt item: #209 of 550 id: ujms-6422 author: Carlsson, Lena ; Lennartsson, Lena ; Ronquist, Gunnar ; Larsson, Anders ; Nilson, Sten ; Nilsson, Ove title: Mode of Growth Determines Differential Expression of Prostasomes in Cultures of Prostate Cancer Cell Lines and Opens for Studies of Prostasome Gene Expression date: 2009-07-12 words: 3227 flesch: 58 summary: Differentially expressed genes related to prostate cancer have been studied in prostate cancer cell lines with various aims (for references, see 18). Zhao H, Kim Y, Lapoint J, Tibshirani R, Pollack JR, Brooks JD (2005) Genome-wide characteri- zation of gene expression variations and DNA copy number changes in prostate cancer cell lines. keywords: cancer; cells; expression; growth; lines; pc3; prostasomes; prostate; spheroids; support cache: ujms-6422.pdf plain text: ujms-6422.txt item: #210 of 550 id: ujms-6423 author: Hagiwara, Yoshihiro ; Saijo, Yoshifumi ; Chimoto, Eiichi ; Akita, Hirotoshi ; Sasano, Yasuyuki ; Matsumoto, Fujio ; Kokubun, Shoichi title: Increased Elasticity of Capsule After Immobilization in a Rat Knee Experimental Model Assessed by Scanning Acoustic Microscopy date: 2009-07-12 words: 4077 flesch: 54 summary: In the present study, we applied a new concept SAM using single pulsed wave, which can make total time for calculation significantly shorter, to examine the elasticity of the anterior and posterior SM (synovial intima and subin- tima) in the course of knee joint immobilization in a rat experimental model. Material and Methods Animals. Experimental immobilization and remobi- lization of rat knee joints. keywords: control; elasticity; group; immobilization; joint; knee; posterior; synovial; tissue cache: ujms-6423.pdf plain text: ujms-6423.txt item: #211 of 550 id: ujms-6424 author: Matsubara, Yoshihiro ; Miyasaka, Yoshinori ; Nobuta, Shingo ; Hasegawa, Kazushige title: Radial Nerve Palsy at the Elbow date: 2009-07-12 words: 2117 flesch: 57 summary: 2. Discussion Orthopedic disorders causing drop finger include, in addition to PIN palsy, cervical myelopathy (radiculopathy) and extensor tendon rupture. Radial nerve in the radial tunnel: Anatomic sites of entrap- ment neuropathy. keywords: cases; elbow; findings; nerve; palsy; pin cache: ujms-6424.pdf plain text: ujms-6424.txt item: #212 of 550 id: ujms-6429 author: Ilchmann, Thomas ; Eingartner, Christoph ; Heger, Katharina ; Weise, Kuno title: Femoral Subsidence Assessment After Hip Replacement date: 2009-07-12 words: 3298 flesch: 60 summary: Conclusions: The main error of subsidence measurement is caused by tilt of the femur for standard methods and partly can be reduced by EBRA-FCA. For subsidence measurements of femoral components various prominent bone markers were proposed. keywords: error; measurement; radiographs; subsidence cache: ujms-6429.pdf plain text: ujms-6429.txt item: #213 of 550 id: ujms-6434 author: Flodin, Mats ; Hansson, Lars-Olof ; Larsson, Anders title: Evaluation of Dade Behring N Latex Cystatin C Reagent on Abbott Ci8200 date: 2009-07-12 words: 1826 flesch: 62 summary: This in combination with a 24 h availability of cystatin C has led to a very rapid increase in cystatin C requests during the last 3 year-period. Reporting cystatin C results in mL/min using conversion formulas for transforming cystatin C expressed as mg/L to GFR expressed as mL/min has greatly facilitated the clinical use of the marker. keywords: behring; creatinine; cystatin; gfr; plasma cache: ujms-6434.pdf plain text: ujms-6434.txt item: #214 of 550 id: ujms-6435 author: Inuwa, I.M.; Williams, M.A. title: A Morphometric Study on the Endometrium of Rat Uterus in Hypothyroid and Thyroxine Treated Hypothyroid Rats date: 2009-07-12 words: 4353 flesch: 58 summary: Ultrastructure of hypothyroid rat uterine horn luminal epithelium As shown in Figures 1B and 2B epithelia from uterine horn in hypothyroid rats were also columnar and lay on a thicker basement membrane than that below normal epithe- lia (Fig 2A). All the epithelial struc- tural changes observed were less pronounced in hypothyroid rats given thyroxine. keywords: basement; cell; epithelium; horn; hypothyroid; hypothyroidism; mean; membrane; rats; study; thyroxine; volume cache: ujms-6435.pdf plain text: ujms-6435.txt item: #215 of 550 id: ujms-6436 author: Agnarsdóttir, Margrét ; Carlén, Birgitta ; Willén, Roger title: Malacoplakia and Spermatic Granuloma Complicating Vasectomy date: 2009-07-12 words: 1005 flesch: 60 summary: J Urol 125:139-146. 2. (7) Upsala J Med Sci 111 (2): 227–230, 2006 Malacoplakia and Spermatic Granuloma Complicating Vasectomy 1Margrét Agnarsdóttir, 2Birgitta Carlén and 1Roger Willén 1Pathology and Cytology, Centre for Laboratory Medicine, Uppsala University Hospital, S-75185 Uppsala, Sweden. 2Department of Pathology, Lund University Hospital, 22185 Lund, Sweden. keywords: disease; fig; malacoplakia; vas cache: ujms-6436.pdf plain text: ujms-6436.txt item: #216 of 550 id: ujms-6437 author: Kotajima, Satoshi ; Kishimoto, Koshi N. ; Watanuki, Munenori ; Hatori, Masahito ; Kokubun, Shoichi title: Gene Expression Analysis of Ectopic Bone Formation Induced by Electroporatic Gene Transfer of BMP4 date: 2009-07-12 words: 3591 flesch: 54 summary: However, these markers of gene expression in this cascade were not assessed after BMP gene transfer but in protein and carrier models (15-17). Parathyroid hormone induces sequential c-fos expression in bone cells in vivo: in situ localization of its receptor and c-fos mes- senger ribonucleic acids. keywords: bmp4; bone; cells; day; expression; formation; gene; mrna; muscle; pcaggs; transfer cache: ujms-6437.pdf plain text: ujms-6437.txt item: #217 of 550 id: ujms-6438 author: Watanuki, Munenori ; Hatori, Masahito ; Kokubun, Shoichi title: SAPHO Syndrome with a Tumour-like Bony Proliferative Lesion in Distal Femur. ACase Report date: 2009-07-12 words: 1594 flesch: 59 summary: Hypertrophic bone lesions are often seen in the anterior chest wall. The patients with skin trouble like acne, when having tumor or osteomyelitis like bony lesions should be suspected to have this syn- drome. keywords: acne; bone; lesions; sapho; syndrome cache: ujms-6438.pdf plain text: ujms-6438.txt item: #218 of 550 id: ujms-6439 author: Sasaki, Daizo ; Hatori, Masahito ; Abe, Yoshinori ; Kokubun, Shoichi title: Ollier's Disease Treated with Grafting Using Alpha-tricalcium Phosphate Cement. ACase Report date: 2009-07-12 words: 2353 flesch: 60 summary: Bone tumors on the proximal phalanx of the right index finger and second matacarpal bone were found and curetted away. Clinical application of pure-beta-TCP for bone tumors. keywords: bone; curettage; finger; hand; ollier; years cache: ujms-6439.pdf plain text: ujms-6439.txt item: #219 of 550 id: ujms-6440 author: Yabe, Yutaka ; Kumagai, Jun ; Koizumi, Noriyuki ; Kawamura, Masanori ; Ono, Sadahide ; Hatori, Masahito title: Osteolipoma Arising Adjacent to the Sternoclavicular Joint: A Case Report date: 2009-07-12 words: 1363 flesch: 62 summary: Hattori K, Hatori M, Watanabe M, Osanai T, Kokubun S. (2004) Scrotum-like protrusion of lipo- ma arising from the proximal thigh report of two cases. 7. Takamatsu K, Hatori M, Ehara S, Kokubun S. (1997) keywords: bone; joint; lipomas; mass; osteolipoma cache: ujms-6440.pdf plain text: ujms-6440.txt item: #220 of 550 id: ujms-6441 author: Hatori, Masahito ; Kotajima, Satoshi ; Smith, Richard A. ; Kokubun, Shoichi title: Ankle Dislocation without Accompanying Malleolar Fracture date: 2009-07-12 words: 1611 flesch: 61 summary: Wehner J, Lorenz M (1990) Lateral ankle dislocation without fracture. Larsen J, Burzotta J, Brunetti V (1998) Ankle dislocation without fracture in a young athlete. keywords: ankle; case; dislocation; fracture cache: ujms-6441.pdf plain text: ujms-6441.txt item: #221 of 550 id: ujms-6442 author: Matsuya, Shigetsune ; Hatori, Masahito ; Hosaka, Masami ; Ito, Katsu ; Dohi, Osamu ; Endo, Mareyuki ; Kokubun, Shoichi title: Operative Treatment by External Fixation for Polyostotic Fibrous Dysplasia in The Elbow Joint: A Case Report date: 2009-07-12 words: 1902 flesch: 59 summary: An external fixator is sometimes employed for the treatment of bone tumors. The indication for its use includes pathological fractures due to bone tumors, and distraction osteogenesis for bone defects after resection or bone grafting. keywords: bone; dysplasia; elbow; fixation; fixator; joint cache: ujms-6442.pdf plain text: ujms-6442.txt item: #222 of 550 id: ujms-6445 author: Hofvander, Yngve title: Violations against Children in a National and International Perspective date: 2009-07-12 words: 2741 flesch: 62 summary: (3) Hofvander 27-34 27 Upsala J Med Sci 111 (1): 27–34, 2006 Violations against Children in a National and International Perspective Yngve Hofvander Department of Women´s and Childrens Health, Uppsala University In his writings, Rosén does not at all discuss violations against children, although this cer- tainly was common in his time. Practices which are listed which should be reviewed in the light of the Convention include “ all forms of genital mutilation and circumcision, binding, scarring, burning, initiation ceremonies e.g. forced holding under water, preferential care of male children, lack of care of disabled children, food taboos, beating chil- dren, early marriage” – et cetera… This horrible list of abuse could be made much longer! keywords: boys; children; circumcision; girls; operation; sweden; years cache: ujms-6445.pdf plain text: ujms-6445.txt item: #223 of 550 id: ujms-6446 author: Gustavson, Karl-Henrik title: From Rosén von Rosenstein to HUGO (The Human Genome Organization) date: 2009-07-12 words: 2619 flesch: 50 summary: The importance of infectious diseases and malnutrition has diminished drastically, at least in developed countries, and the importance of genetic diseases has increased. Genetic diseases are thus a significant cause of illness and death. keywords: child; children; chromosome; diseases; disorders; dna; genes; genetics cache: ujms-6446.pdf plain text: ujms-6446.txt item: #224 of 550 id: ujms-6447 author: Sedin, Gunnar ; Ågren, Johan title: Water and Heat – The Priority for the Newborn Infant date: 2009-07-12 words: 4185 flesch: 64 summary: In preterm infants, especially in those who are extremely preterm, who have very high insensible water losses, sometimes leading to hyperosmolality, high levels of water loss have to be avoided. Thus there is no indication that radiant heat increases water loss from the skin under conditions with a low air velocity close to the infant. keywords: age; birth; heat; infants; loss; preterm; sedin; skin; water cache: ujms-6447.pdf plain text: ujms-6447.txt item: #225 of 550 id: ujms-6448 author: Nevéus, Tryggve title: The Evaluation and Treatment of Therapy-Resistant Enuresis: A Review date: 2009-07-12 words: 4722 flesch: 52 summary: Children with diuresis-dependent enuresis usually respond to desmopressin (7), which is logical, given the drug’s antidiuretic action, whereas the factors that determine whether alarm treatment will work or not are related primarily to the motivation and ability of the family and child to follow the instructions given by the care-giver, and partly also to the degree of arousal disturbance. It is also known that, although the old notion of enuresis as a primarily psychiatric disor- der has not stood the test of time, neuropsychiatrical disturbances, such as attention deficit hyperactivity disorder, are overrepresented among enuretic children (8). keywords: bladder; children; constipation; day; enuresis; imipramine; incontinence; nocturnal; time; treatment cache: ujms-6448.pdf plain text: ujms-6448.txt item: #226 of 550 id: ujms-6449 author: Rodriguez, Alina ; Tuvemo, Torsten ; Hansson, Mats G. title: Parents’ Perspectives on Research Involving Children date: 2009-07-12 words: 5843 flesch: 51 summary: Parental ratings of agencies/persons' degree of involvement in risk-evaluation for child research participants and parents' willingness to allow children to participate in research were the main outcome measures. Systematic exclusion of children in research unjustly denies them access to benefits of research participation, i.e. evidence-based medicine. keywords: care; children; medical; mothers; parents; participation; research; risk; table; week; willingness; women cache: ujms-6449.pdf plain text: ujms-6449.txt item: #227 of 550 id: ujms-6450 author: Ljungman, Gustaf ; Kreuger, Anders ; Gordh, Torsten ; Sörensen, Stefan title: Pain in Pediatric Oncology: Do the Experiences of Children and Parents Differ from Those of Nurses and Physicians? date: 2009-07-12 words: 3539 flesch: 59 summary: In particular, we focused on the extent and causes of pain, strategies to reduce procedural pain, pain evaluation, and attitudes to pain treatment. Although there have been improvements in pain treatment in the last decades, pain and underestimation of pain are still common problems in pediatric oncology (1-6). keywords: cancer; children; nurses; pain; parents; physicians; professionals; treatment cache: ujms-6450.pdf plain text: ujms-6450.txt item: #228 of 550 id: ujms-6451 author: Funkquist, E-L.; Tuvemo, T.; Jonsson, B.; Serenius, F.; Hedberg-Nyqvist, K. title: Growth and Breastfeeding among Low Birth Weight Infants Fed with or without Protein Enrichment of Human Milk date: 2009-07-12 words: 5629 flesch: 65 summary: One factor that emerged as significant for explaining infant length at 12 and 18 months corrected age was SDS for length at birth. The aim of this study was to describe feeding and growth of infants weighing <1,900 g at birth, up to a cor- rected age of 18 months, with or without protein-enriched breastmilk. keywords: birth; breastfeeding; discharge; growth; head; infants; months; non; sds; weight cache: ujms-6451.pdf plain text: ujms-6451.txt item: #229 of 550 id: ujms-6452 author: Calissendorff-Selder, Maria ; Ljungman, Gustaf title: Quality of Life Varies with Pain during Treatment in Adolescents with Cancer date: 2009-07-12 words: 3272 flesch: 60 summary: Treatment- and procedure-related pain have previously been shown to be greater problems than cancer pain, and thus most pain experienced by children may be regarded as iatrogenic (10,11). This finding emphasizes the impor- tance of pain management in children and adolescents with cancer. keywords: adolescents; cancer; children; life; pain; pgwb; quality; treatment cache: ujms-6452.pdf plain text: ujms-6452.txt item: #230 of 550 id: ujms-6453 author: Proos, LA ; Lönnerholm, T; Jonsson, B; Tuvemo, T title: Can Bone Age Determination Provide Criteria for Growth Hormone Treatment in Adopted Girls with Early Puberty? date: 2009-07-12 words: 4444 flesch: 68 summary: Greulich - Pyle Further analysis of PAH according to GP and final height (Fig 2), showed that all subjects with a PAH >157 cm (19 patients out of 46, 10 in the GnRHa group and 9 in the combined group), attained normal final height (>-2SDS or 153 cm) irrespecti- ve of treatment with GH. In conclusion, these data indicate that in the great majority of cases of adopted girls with early puberty final height after GnRH analogue treatment can be predic- ted using Greulich – Pyle / Bayley – Pinneau prediction. keywords: age; girls; gnrha; group; growth; height; puberty; treatment cache: ujms-6453.pdf plain text: ujms-6453.txt item: #231 of 550 id: ujms-6454 author: Gustafsson, Jan ; Alvelius, Gunvor ; Björkhem, Ingemar ; Nemeth, Antal title: Bile Acid Metabolism in Extrahepatic Biliary Atresia date: 2009-07-12 words: 2487 flesch: 60 summary: There was no evidence for presence of C27-bile acids, neither in the samples of the patients nor in those of the controls. 134 Table 1 Concentrations of bile acids (µmol/l, mean±S.E.M.) in stored dried blood collected at neonatal metabolic screening from six patients with EHBA and 14 controls Lithocholic acid Cholic acid Chenodeoxycholic acid Patients 0.11±0.04 15.6±3.6 7.4±2.5 Controls 0.08±0.02 1.7±0.3 1.8±0.4 Table 1. Concentrations of bile acids (µ mol/l, mean±S.E.M.) in stored dried blood collected at neonatal metabolic screening from six patients with EHBA and 14 controls 135 DISCUSSION Dried blood, obtained at neonatal screening, is used to detect several metabolic and endocrine diseases. keywords: acid; bile; biliary; blood; infants; lca; liver; patient cache: ujms-6454.pdf plain text: ujms-6454.txt item: #232 of 550 id: ujms-6456 author: Roomans, Godfried M. ; Ivanovs, Andrejs ; Shebani, Eyman B. ; Johannesson, Marie title: Transmission Electron Microscopy in the Diagnosis of Primary Ciliary Dyskinesia date: 2009-07-12 words: 6898 flesch: 60 summary: Headache, a common complaint in PCD patients, has been associated with absence of cilia in the brain ventricles, lead- ing to decreased circulation of the cerebrospinal fluid. This means that PCD patients had significantly more manifested disori- entation of cilia compared to SCD patients (p<0.0001). keywords: arms; beat; cell; ciliary; cor; dynein; dyskinesia; immotile; normal; number; patients; pcd; primary; scd; situs; syndrome cache: ujms-6456.pdf plain text: ujms-6456.txt item: #233 of 550 id: ujms-6457 author: Wide, Leif title: Inventions Leading to the Development of the Diagnostic Test Kit Industry – From the Modern Pregnancy Test to the Sandwich Assays date: 2009-07-12 words: 10020 flesch: 55 summary: These were sui- table for laboratories performing larger series of pregnancy tests using test tubes with a hemispherical bottom. Ancient pregnancy tests in the light of contemporary knowledge. keywords: allergy; antibodies; antibody; antigen; assay; binding; hcg; particles; pharmacia; phase; pregnancy; pregnancy test; reaginic; sandwich; technique; test; urine cache: ujms-6457.pdf plain text: ujms-6457.txt item: #234 of 550 id: ujms-6458 author: Almroth, G; Lindell, Å; Åselius, H; Sörén, L; Svensson, L; Hultman, P; Eribe, ERK; Olsen, I title: Acute Glomerulonephritis Associated with Streptococcus Pyogenes with Concomitant Spread of Streptococcus Constellatus in Four Rural Families date: 2009-07-12 words: 5541 flesch: 58 summary: Group G streptococci have been considered to be less pathogenic than group C streptococci but have been associated both with glomeru- lonephritis and renal failure Phenotypic typing of group C streptococci Further typing of group C streptococci was performed with API Strep from Bio- Mérieux sa Marcy l´Étoile, France. keywords: acute; constellatus; dna; fig; gcs; glomerulonephritis; group; kidney; lancefield; patient; pyogenes; streptococci; throat cache: ujms-6458.pdf plain text: ujms-6458.txt item: #235 of 550 id: ujms-6459 author: Dahlgren, Eva ; Gull, Berit ; Willén, Roger ; Sundler, Frank ; Rosén, Thord ; Jansson, Per-Anders title: Sertoli-Leydig Cell Tumour in a Postmenopausal Woman Showing all Facets of the Insulin Resistance Syndrome (IRS) date: 2009-07-12 words: 1249 flesch: 53 summary: Tumour cells were 234 Fig 1: Overview of the Sertoli Leydig Cell Tumour, with Sertoli tubules at the bottom and clusters of Leydig cells at the top. Strong inhibin immunoreactivity in both Sertoli as well as in Leydig cell com- ponents. keywords: cell; insulin; leydig; sertoli; tumour cache: ujms-6459.pdf plain text: ujms-6459.txt item: #236 of 550 id: ujms-6460 author: Yokota, Takashi ; Yamaki, Takayuki ; Yashima, Rei ; Yamada, Yasuo ; Narushima, Yoichi ; Kikuchi, Shu ; Yamauchi, Hidemi ; Hatori, Masahito title: Emergency Operation for Phlegmonous Gastritis date: 2009-07-12 words: 1225 flesch: 47 summary: Radiographic findings of phlegmonous gastritis resemble those of scirrhous gastric cancer. Although the disease usually shows characteristic macroscopic and histological findings1, the diagnosis may contribute to problem and it is sometimes difficult to distinguish phlegmonous gastritis from scirrhous gastric cancer. keywords: cancer; gastric; gastritis; phlegmonous cache: ujms-6460.pdf plain text: ujms-6460.txt item: #237 of 550 id: ujms-6461 author: Yokota, Takashi ; Iwamoto, Kazutsugu ; Watanabe, Yuko ; Yamauchi, Hidemi ; Kikuchi, Shu ; Hatori, Masahito title: Pyogenic Liver Abscesses Secondary to Carcinoma of the Sigmoid Colon date: 2009-07-12 words: 1332 flesch: 54 summary: ABSTRACT We report a case of liver abscesses associated with sigmoid colon cancer in an 81-year- old woman. Nineteen cas- es of liver abscess associated with colonic cancer have been reported during the past ten years in Japan, and we report the clinical features of these cases in this paper. keywords: abscess; abscesses; colon; liver cache: ujms-6461.pdf plain text: ujms-6461.txt item: #238 of 550 id: ujms-6462 author: Hatori, Masahito ; Watanabe, Mika ; Kokubun, Shoichi title: Angiomyolipoma in the Knee-A Case Report date: 2009-07-12 words: 1762 flesch: 60 summary: The significance of lymph nodal involvement in renal angiomyolipoma. Signs of tuberous sclerosis or renal angiomyolipoma were absent in all these cases [9]. keywords: angiomyolipoma; case; cells; knee; tissue; tumor cache: ujms-6462.pdf plain text: ujms-6462.txt item: #239 of 550 id: ujms-6463 author: Hatori, Masahito ; Watanabe, Mika ; Watanabe, Hiroshi ; Hosaka, Masami ; Kokubun, Shoichi title: Desmoplastic Melanoma Arising in The Ankle date: 2009-07-12 words: 2107 flesch: 56 summary: The most reliable and characteristic features of an early lesion of DM are aggregates of lymphocytes, tumour cells showing cytological atypia, stromal myxoid appearance, and poor circumscription of the dermal infiltrate [1]. The histological diagnosis was desmoplastic malignant melanoma. keywords: cells; image; mass; melanoma; tumour cache: ujms-6463.pdf plain text: ujms-6463.txt item: #240 of 550 id: ujms-6464 author: Sasaki, Daizo ; Hatori, Masahito ; Hosaka, Masami ; Watanabe, Mika ; Kokubun, Shoichi title: Lipofibromatosis Arising in a Pediatric Forearm: A Case Report date: 2009-07-12 words: 1262 flesch: 60 summary: Recognition of this clinical entity is needed, especially in cases of lipomatous tumours arising in pediatric hands and feet. Key words: lipofibromatosis, lipomatous tumour, infant, radiological finding CASE REPORT A ten-month-old boy was referred to our clinic with a painless and slow-growing tumour in the right forearm. keywords: fig; tissue; tumour cache: ujms-6464.pdf plain text: ujms-6464.txt item: #241 of 550 id: ujms-6465 author: Vesti Nielsen, Jørgen ; Jönsson, Eva ; Ivarsson, Anette title: A Low Carbohydrate Diet in Type 1 Diabetes: A Brief Report date: 2009-07-12 words: 2946 flesch: 67 summary: Patients with type 1 diabetes commonly take fixed pre-meal doses of insulin. However, by way of education, patients can learn to estimate the carbohydrate content of a meal and to match the insulin accordingly. keywords: carbohydrate; diabetes; glucose; hba1c; insulin; months; patients cache: ujms-6465.pdf plain text: ujms-6465.txt item: #242 of 550 id: ujms-6466 author: Tobin, Gerard title: The Immunoglobulin genes and Chronic Lymphocytic Leukemia (CLL) date: 2009-07-12 words: 9178 flesch: 65 summary: Rettig MB, Vescio RA, Cao J, et al. VH gene usage is multiple myeloma: complete absence of the VH4.21 (VH4-34) gene. Tobin G, Thunberg U, Laurell A, et al. VH gene mutation analysis distinguishes a subgroup of chron- ic lymphocytic leukemia with low-mutated VH genes and inferior outcome. keywords: blood; cases; cell; chronic; cll; et al; gene; h gene; leukemia; mutated; survival; unmutated; v h cache: ujms-6466.pdf plain text: ujms-6466.txt item: #243 of 550 id: ujms-6467 author: Sjöblom, Markus title: The Duodenal Mucosal Bicarbonate Secretion date: 2009-07-12 words: 15355 flesch: 55 summary: Flemström G. Gastric and duodenal mucosal secretion of bicarbonate. The main findings were as follows: Melatonin is a potent stimulant of duodenal mucosal bicarbonate secretion and also seems to be involved in the acid-induced stimulation of the secretion. keywords: acid; alkaline; bicarbonate; bicarbonate secretion; ca2; calcium; cells; duodenum; enterocytes; experiments; fig; flemström; gastrointestinal; hco; increase; intracellular; liver; melatonin; mucosal; mucosal bicarbonate; physiol; pineal; rat; rats; receptors; response; secretion; secretory; stimulation; system; tract cache: ujms-6467.pdf plain text: ujms-6467.txt item: #244 of 550 id: ujms-6468 author: Larsson, Anders ; Hansson, Lars-Olof title: Inflammatory activity: Capillary electrophoresis provides more information than erythrocyte sedimentation rate date: 2009-07-12 words: 2605 flesch: 55 summary: Any condition that causes a general increase of acute phase proteins (e.g. infectious diseases, polymyalgia rheumatica, temporalis arteritis, diabetes mellitus, heart disease, malig- nancies, renal failure and pregnancy) will also elevate ESR Assay time with the Capillarys® capillary electrophoresis system is less than 10 min. With an automatic interpretation program it should be possible to perform cap- illary electrophoresis determination of acute phase proteins with shorter turn-around times than ESR, with concomitant determination and quantification of M-compo- nents. keywords: electrophoresis; erythrocyte; esr; fibrinogen; phase; rate; samples cache: ujms-6468.pdf plain text: ujms-6468.txt item: #245 of 550 id: ujms-6469 author: Zulfikaroglu, Baris ; Koc, Mahmut ; Ozalp, Necdet ; Ozmen, M Mahir title: A Rare Primary Location of Echinococcal Disease: Report of a Case date: 2009-07-12 words: 1212 flesch: 54 summary: Laparotomy was performed via a right subcostal incision on the presumptive diagnosis of hydatid cyst. Although hydatid cysts were known commonly to affect the liver, lung, spleen, it also affects the brain, heart, kidney, ureter, uterus, fallopian tube, mesentery, pancreas, diaphragm, and muscles (3, 4). keywords: case; cyst; disease; echinococcus; hydatid cache: ujms-6469.pdf plain text: ujms-6469.txt item: #246 of 550 id: ujms-6470 author: Mattsson, Göran title: The Endothelial Cells in Islets of Langerhans date: 2009-07-12 words: 6299 flesch: 53 summary: To understand the role of islet endothelium in the revascularization of transplanted islets we performed angio- genesis microarray studies on islet endothelial cells, from non-cultured, cultured and transplanted islets. A regulatory defect of constitutive no-syn- thase in islet endothelial cells correlates with probability of disease manifestation in BBdp rats. keywords: blood; cells; density; diabetes; endocrine; endothelial; insulin; islets; langerhans; liver; studies; tissue; transplantation; type; vascular; vessels cache: ujms-6470.pdf plain text: ujms-6470.txt item: #247 of 550 id: ujms-6472 author: Jansson, Leif ; Bodin, Birgitta ; Carlsson, Per-Ola title: Changes in Graft Blood Flow early after Syngeneic Rat Pancreas-Duodenum Transplantation date: 2009-07-12 words: 4382 flesch: 57 summary: ujms110_1.pdf Upsala J Med Sci 109: 57–68, 2004 Changes in Graft Blood Flow early after Syngeneic Rat Pancreas-Duodenum Transplantation Leif Jansson,1 Birgitta Bodin1 and Per-Ola Carlsson1, 2 1Department of Medical Cell Biology and 2Department of Medical Sciences, Uppsala University, Uppsala, Sweden ABSTRACT A free full-text copy of this article can be found at the web page of Upsala J Med Sci: http://www.ujms.se Organ transplantation is associated with changes in graft blood flow, both acutely caused by reperfusion associated phenomena, and chronically due to e.g. denerva- tion. We have previously demonstrated that alloxan, a substance exert- ing a major part of its diabetogenic effect through ROS (10), has a marked influence on pancreatic islet blood flow, and is one of the most powerful potentiators of islet blood perfusion seen (11). keywords: blood; blood flow; control; duodenum; flow; graft; islet; min; pancreas; rats; reperfusion; transplantation cache: ujms-6472.pdf plain text: ujms-6472.txt item: #248 of 550 id: ujms-6476 author: Heldin, Carl-Henrik title: Development and possible clinical use of antagonists for PDGF and TGF-β date: 2009-07-12 words: 6714 flesch: 56 summary: Overactivity of PDGF or PDGF receptors contributes to the development of cer- tain diseases characterized by excessive cell growth including fibrotic disorders, atherosclerosis and malignancies. On one hand, activa- tion of PDGF receptors, by mutational events or by constitutive autocrine stimula- tion by ligand, may drive the proliferation and survival of tumor cells. keywords: antagonists; cancer; cell; development; factor; gene; growth; heldin; kinase; molecules; pdgf; platelet; receptor; signaling; smad; tgf-; treatment; tumor; type cache: ujms-6476.pdf plain text: ujms-6476.txt item: #249 of 550 id: ujms-6477 author: Molin, Daniel title: Bystander Cells and Prognosis in Hodgkin Lymphoma date: 2009-07-12 words: 23549 flesch: 66 summary: Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Hodgkin disease: pharma- cologic intervention of the CD40-NF kappa B pathway by a protease inhibitor. keywords: abvd; ann; blood; cancer; cases; cationic; cd30l; cells; chemotherapy; classification; clin; correlation; diehl; disease; ecp; effects; eosinophils; expression; factors; field; group; histology; hl patients; hodgkin; hodgkin disease; hrs cells; human; line; lymphoma; mast cells; mopp; new; number; oncol; patients; prognostic; protein; radiotherapy; reed; results; risk; role; stage; stage hodgkin; staging; sternberg; study; survival; time; treatment; tumours; years cache: ujms-6477.pdf plain text: ujms-6477.txt item: #250 of 550 id: ujms-6478 author: Johansson, Katarina ; Darj, Elisabeth title: What type of information do parents need after being discharged directly from the delivery ward? date: 2009-07-12 words: 3936 flesch: 69 summary: Questions about breast-feeding Breast-feeding positions, nipples Nine couples had questions about various breast-feeding positions, the child’s posi- tion at the breast and the correct sucking technique at the nipple. It could be of interest to know what kind of questions families who stay at the postnatal ward have, if it differs from those who leave the hospital early. keywords: breast; child; feeding; home; midwife; parents; questions cache: ujms-6478.pdf plain text: ujms-6478.txt item: #251 of 550 id: ujms-6479 author: Kollur, Sharanamma M ; Pattankar, V.L.; Abdien El Hag, Imad title: Mast cells in testicular lesions date: 2009-07-12 words: 2476 flesch: 63 summary: Toluidine blue stained sections were examined under high power magnification (hpm) and the number of mast cell present in 10 consecutive fields was counted. There was a considerable variation in the number and distribution of mast cells in various testicular lesions. keywords: cells; distribution; hpm; infertility; lesions; mast; mast cells; number; testicular cache: ujms-6479.pdf plain text: ujms-6479.txt item: #252 of 550 id: ujms-6480 author: Hallberg, Pär ; Melhus, Håkan ; Hansson, Lars-Olof ; Larsson, Anders title: Cystatin C vs creatinine as markers of renal function in patients on digoxin treatment date: 2009-07-12 words: 2786 flesch: 63 summary: S-digoxin correlated stronger to s-cystatin C as compared to s-creatinine, which is in agreement with previous studies showing s-cystatin C to be superior to s-creati- nine as a marker of renal function Our hospital has for the last year offered measurements of s-cystatin C as a STAT request and also reported cystatin C in mg/L as well as converted to GFR (mL/min). keywords: creatinine; cystatin; digoxin; gfr; patients; serum cache: ujms-6480.pdf plain text: ujms-6480.txt item: #253 of 550 id: ujms-6481 author: Agnarsdóttir, Margrét ; Willén, Roger ; Abdien El Hag, Imad title: Three Cases of Malacoplakia of the Gallbladder date: 2009-07-12 words: 1137 flesch: 60 summary: 2. Michaelis L, Gutmann C (1902). ABSTRACT A free full-text copy of this article can be found at the web page of Upsala J Med Sci: http://www.ujms.se Malacoplakia is a granulomatous disease with a histiocytic infiltrate containing cal- cified bodies called Michaelis-Gutmann bodies considered to represent an abnormal response to infection involving defective lysosomes and abnormal microtubular assembly. keywords: bodies; case; gallbladder; malacoplakia cache: ujms-6481.pdf plain text: ujms-6481.txt item: #254 of 550 id: ujms-6482 author: Hattori, Koshi ; Hatori, Masahito ; Watanabe, Mika ; Osanai, Toshihisa ; Kokubun, Shoichi title: Scrotum-like protrusion of lipoma arising from the proximal thigh date: 2009-07-12 words: 1326 flesch: 64 summary: Imaging of fatty tumors: distinction of lipoma and well-differentiated liposarcoma. The mass showed iso-density to subcutaneous fatty tissue on CT scan. keywords: lipoma; thigh; tissue; tumor cache: ujms-6482.pdf plain text: ujms-6482.txt item: #255 of 550 id: ujms-6484 author: James, Stefan title: Coagulation, inflammation and myocardial dysfunction in unstable coronary artery disease and the influence of glycoprotein IIb/IIIa inhibition and low molecular weight heparin date: 2009-07-12 words: 19856 flesch: 55 summary: Yeghiazarians Y, Braunstein JB, Askari A et al. (2000). Little WC, Constantinescu M, Applegate RJ, et al (1998). keywords: abciximab; acs; acute; angina; artery; circulation; coagulation; crp; dalteparin; death; disease; elevation; et al; heart; heparin; hours; iib; iiia; infarction; levels; markers; mortality; patients; platelet; probnp; risk; study; treatment; trial; troponin cache: ujms-6484.pdf plain text: ujms-6484.txt item: #256 of 550 id: ujms-6485 author: Onoda, Satsuki ; Hatori, Masahito ; Yamada, Norikazu ; Hosaka, Masami ; Kokubun, Shoichi title: A Two- stage surgery for severe femoral neck deformity due to fibrous dysplasia: A case report date: 2009-07-12 words: 1638 flesch: 64 summary: A case report Satsuki Onoda, Masahito Hatori, Norikazu Yamada, Masami Hosaka, Shoichi Kokubun Department of Orthopaedic, Surgery Tohoku University School of Medicine, 1-1 Seiryomachi, Aobaku, Sendai, Japan 980-8574 ABSTRACT A free full-text copy of this article can be found at the web page of Upsala J Med Sci: http://www.ujms.se Various kinds of surgical treatments have been reported for varus deformity of the proximal femur due to fibrous dysplasia. Various kinds of surgical tre- atments have been reported for this type of varus deformity (1–5). keywords: bone; deformity; dysplasia; neck; varus cache: ujms-6485.pdf plain text: ujms-6485.txt item: #257 of 550 id: ujms-6486 author: Hatori, Masahito ; Miyasaka, Yoshinori ; Kimura, Itaru ; Smith, Richard A. ; Kokubun, Shoichi title: Field Distribution of Compound Muscle Action Potentials of the Calf Muscles in Rabbits date: 2009-07-12 words: 2523 flesch: 60 summary: 131 Received 9 December 2003 Accepted 2 February 2004 Key words: compound muscle action potential, electromyography, nerve root potential, stationary potential, far field potential, volume conduction. For recording stationary potentials originating from the calf muscle’s CMAPs, multiple electrodes were placed in 5 cm increments along the ipsilateral sciatic nerve, the spinous process and the head (Fig. 1). keywords: calf; muscle; nerve; potential; recording; referential cache: ujms-6486.pdf plain text: ujms-6486.txt item: #258 of 550 id: ujms-6578 author: Tutor-Crespo, María J. ; Hermida, Jesús ; Tutor, J. Carlos title: Relative Proportions of Serum Carbamazepine and its Pharmacologically Active 10,11-Epoxy Derivative: Effect of Polytherapy and Renal Insufficiency date: 2008-07-12 words: 3336 flesch: 53 summary: The principal pathway of CBZ metabolism is oxidation to the pharmacologically active carbamazepine-10,11-epoxide (CBZE), and then hydration to inactive trans- carbamazepine-10,11-diol (CBZD) (1,2). Abstract Background: The proposed action mechanism and pharmacological activity of car- bamazepine (CBZ) and its major metabolite, carbamazepine-10,11-epoxide (CBZE), are the same. keywords: carbamazepine; cbz; cbze; drug; emit; gfr; patients; serum cache: ujms-6578.pdf plain text: ujms-6578.txt item: #259 of 550 id: ujms-6579 author: Nobuta, Shingo ; Sato, Katsumi ; Nakagawa, Tomowaki ; Hatori, Masahito ; Itoi, Eiji title: Effects of Wrist Splinting for Carpal Tunnel Syndrome and Motor Nerve Conduction Measurements date: 2008-07-12 words: 4951 flesch: 66 summary: recordings of intracarpal pressure in carpal tunnel syndrome patients with and without splinting. untitled Effects of wrist splinting for carpal tunnel syndrome 181 Key words: carpal tunnel syndrome, wrist splint, nerve conduction measurement Received 20 February 2008 Accepted 31 March 2008 Upsala J Med Sci 113 (2): 181–192, 2008 Effects of Wrist Splinting for Carpal Tunnel Syndrome and Motor Nerve Conduction Measurements Shingo Nobuta1, Katsumi Sato1, Tomowaki Nakagawa2, Masahito Hatori3, Eiji Itoi3 1 Department of Orthopaedic Surgery, Tohoku Rosai Hospital, 2 Department of Ortho- paedic Surgery, Iwate Prefectural Iwai Hospital, 3 Department of Orthopaedic Surgery, Tohoku University, School of Medicine Abstract Background: Carpal tunnel syndrome (CTS) is one of the most common disease among the entrapment neuropathies. keywords: apb; carpal; cmap; hands; results; splinting; treatment; tunnel; wrist cache: ujms-6579.pdf plain text: ujms-6579.txt item: #260 of 550 id: ujms-6580 author: Yilmaz, Adnan ; Ertugrul, Muyesser ; Tuncer, Leyla Yagci ; Sulu, Ebru ; Damadoglu, Ebru title: Multiple Primary Malignancies Involving Lung: An Analysis of 40 Cases date: 2008-07-12 words: 3201 flesch: 68 summary: In this study, we aimed to assess the incidence of multiple primary malignancies in primary lung cancer patients. Multiple primary lung cancers. keywords: cancer; cases; lung; malignancies; patients; primary; surgery; tumour; years cache: ujms-6580.pdf plain text: ujms-6580.txt item: #261 of 550 id: ujms-6581 author: Nobuta, Shingo ; Ogawa, Kazuhiro ; Sato, Katsumi ; Nakagawa, Tomowaki ; Hatori, Masahito ; Itoi, Eiji title: Clinical Outcome of Fragment Fixation for Osteochondritis Dissecans of the Elbow date: 2008-07-12 words: 3430 flesch: 57 summary: Treatment in the 202 Shingo Nobuta et al. early stage of OCD lesions is conservative and spontaneous healing is possible (1, 2), but surgical treatment should be applied to advanced lesions. The early stage of OCD lesions, which are observed as radiolucent cystic areas on radiograph are commonly treated conservatively with prohibition of sporting activities and rest of the arm. keywords: capitellum; dissecans; elbow; fixation; fragment; healing; lesion; patients cache: ujms-6581.pdf plain text: ujms-6581.txt item: #262 of 550 id: ujms-6582 author: Ando, Akira ; Hatori, Masahito ; Hosaka, Masami ; Hagiwara, Yoshihiro ; Kita, Atsushi ; Itoi, Eiji title: Eosinophilic granuloma arising from the pelvis in children: A report of three cases date: 2008-07-12 words: 2964 flesch: 58 summary: We could not distinguish EG from malignant bone tumors such as Ewing’s sarcoma or acute osteomyelitis in the case 3 and a chronic osteomyelitis or benign bone tumors in the case 1 and 2. For example, Hand-Schüller-Christian disease is defined as a triad of exophthalmos, diabetes insipidus and osteolytic lesions of the skull, and Letterer-Siwe disease shows hepatosplenomegaly, lymphadenopathy, skin rash, fe- ver, anemia and thrombocytopenia keywords: bone; figure; images; lesion; pelvis cache: ujms-6582.pdf plain text: ujms-6582.txt item: #263 of 550 id: ujms-6583 author: Holmberg, Leif ; Forsgren, Lillemor ; Kristerson, Lars title: Porous Titanium Granules for Implant Stability and Bone Regeneration – a case followed for 12 years date: 2008-07-12 words: 781 flesch: 57 summary: Abstract The clinical and radiological results were excellent for each of the nine fixtures indi- vidually tested in a case followed for 12 years after implant treatment using split crest technique in combination with porous titanium granules for an augmentation of the dento-alveolar ridge in a severely resorbed maxilla. However, as there still may be a problem to achieve a sufficient bone ingrowth around the fixtures in case of a severely resorbed dento-alveolar ridge, we used porous titanium granules, which previously have been used to stabilize hip prostheses (3, 4), to enhance bone regeneration. keywords: bone; granules; titanium cache: ujms-6583.pdf plain text: ujms-6583.txt item: #264 of 550 id: ujms-6584 author: Hagiwara, Yoshihiro ; Chimoto, Eiichi ; Takahashi, Ichiro ; Ando, Akira ; Sasano, Yasuyuki ; Itoi, Eiji title: Expression of transforming growth factor-β1 and connective tissue growth factor in the capsule in a rat immobilized knee model date: 2008-07-12 words: 6344 flesch: 57 summary: Transforming growth factor β1 (TGF-β) induced neutrophil recruitment to synovial tis- sues: implications for TGF-β-driven synovial inflammation and hyperplasia. Posterior capsule: 3 days vs. 1, 4, 8, and 16 weeks; 1 week vs. 2, 4, 8, and 16 weeks; and 2 weeks vs. 4, 8, and 16 weeks) and CTGF expression (Anterior capsule: 3 days vs. 1, 4, 8, and 16 weeks; 1 week vs. 8, and 16 week; 2 weeks vs. 4, 8, and 16 weeks; and 4 weeks vs. 8 and 16 weeks. keywords: capsule; cells; control; ctgf; expression; factor; fibrosis; group; growth; immobilization; joint; knee; rat; staining; tgf; tissue; weeks cache: ujms-6584.pdf plain text: ujms-6584.txt item: #265 of 550 id: ujms-6585 author: Tokyol, Cigdem ; Aktepe, Fatma ; Hüsniye Dilek, Fatma ; Yilmazer, Mehmet title: Comparison of Placental PTEN and β1 Integrin Expression in Early Spontaneous Abortion, Early and Late Normal Pregnancy date: 2008-07-12 words: 3529 flesch: 47 summary: It was concluded that stromal and epithelial compartments contribute to the hormone-driven changes in endometrial PTEN expression and inferred that abnormal hormonal conditions may disrupt normal patterns of PTEN expression in this tissue (13). There was no significant difference between β1 integrin expression of villous trophoblast and decidual cells in three groups. keywords: abortion; cells; expression; human; integrin; placental; pregnancy; pten; staining; tissues cache: ujms-6585.pdf plain text: ujms-6585.txt item: #266 of 550 id: ujms-6586 author: Yilmaz, Adnan; Damadoglu, Ebru; Salturk, Cuneyt; Okur, Erdal; Yagci Tuncer, Leyla; Halezeroglu, Semih title: Delays in the Diagnosis and Treatment of Primary Lung Cancer: Are Longer Delays Associated with Advanced Pathological Stage? date: 2009-07-12 words: 3776 flesch: 62 summary: Delays during the course between the first symptom and thoracotomy in lung cancer patients were a common problem among our patients. It has been documented that the survival and cure rates are higher in cancer patients diagnosed in the earlier stages (4, 5). keywords: cancer; days; delay; doctor; interval; lung; patients; stage cache: ujms-6586.pdf plain text: ujms-6586.txt item: #267 of 550 id: ujms-6587 author: Chen, Gang; Luo, Dianzhong title: Over-expression of Decoy Receptor 3 in Gastric Precancerous Lesions and Carcinoma date: 2009-07-12 words: 3316 flesch: 52 summary: In addition, DcR3 expression in both lymph node metastasis-negative patients and patients without systemic metastasis was significantly decreased in comparison with that in lymph node metastasis-positive patients(P<.05) and patients with systemic metastasis (P<.001). Results DcR3 expression in different gastric tissue Positive immunostaining for DcR3 was observed in the cytoplasm of gastric epi- thelial cells and cancer cells with different rates in different types of lesions (Image 1A, Image 1B, Image 1C, Image 1D). keywords: cancer; cells; dcr3; decoy; dysplasia; expression; gastric; lesions; patients; receptor cache: ujms-6587.pdf plain text: ujms-6587.txt item: #268 of 550 id: ujms-6588 author: Ekerhovd, Erling; Faurskov, Anders; Werner, Charlotte title: Swedish Sperm Donors Are Driven by Altruism, but Shortage of Sperm Donors Leads to Reproductive Travelling date: 2009-07-12 words: 3421 flesch: 62 summary: In Denmark, sperm donors remain anonymous to recipients and offspring, and donor sperm are used to achieve pregnancy by insemination or IVF for single women as well as lesbian couples (4). In the present study we intended to determine why some men become sperm donors in a non-anonymous system by examining the socio-demographic backgrounds, motivations and attitudes of Swedish sperm donors. keywords: couples; donation; donors; fertility; sperm; treatment cache: ujms-6588.pdf plain text: ujms-6588.txt item: #269 of 550 id: ujms-6589 author: Öhman, Marie; Åkerfeldt, Torbjörn; Nilsson, Ingela; Rosen, Christer; Hansson, Lars-Olof; Carlsson, Martin ; Larsson, Anders title: Biochemical Effects of Consumption of Eggs Containing Omega-3 Polyunsaturated Fatty Acids date: 2009-07-12 words: 3356 flesch: 61 summary: Change in percent- age in alpha-linolenic acid (ALA) during consumption of regular eggs (�) and ω-3- enriched eggs (▲) in relation to values at the beginning of the period. untitled Consumption of omega-3 enriched eggs 315 Keywords: Apolipoprotein A1, Apolipoprotein B, glucose, human, eggs, omega-3 Received 15 June 2008 Accepted 17 June 2008 Upsala J Med Sci 113 (3): 315–324, 2008 Biochemical Effects of Consumption of Eggs Containing Omega-3 Polyunsaturated Fatty Acids Marie Öhman1, Torbjörn Åkerfeldt2, Ingela Nilsson3, Christer Rosen4, Lars-Olof Hansson2, Martin Carlsson3 and Anders Larsson2 1Primary Health Care, Landstinget Västmanland, Section of Clinical Chemistry, 2De- partment of Medical Sciences, Uppsala University Hospital, Uppsala, 3Department of Clinical Chemistry, Kalmar County Hospital, Kalmar, 4Källlbergs Industri AB, Töreboda, Sweden Abstract Today, eggs with an increased content of ω-3 fatty acids are available but there are few publications on the effects of consumption of such eggs on the lipoproteins and acute phase markers in humans. keywords: acid; apolipoprotein; cholesterol; consumption; eggs; fatty; study; ω-3 cache: ujms-6589.pdf plain text: ujms-6589.txt item: #270 of 550 id: ujms-6590 author: Shahabi, Shohreh; Smith, Nicole A.; Chanana, Charu; Abbott, J. Dawn; Copel, Joshua; Setaro, John F. title: Pregnancy- associated myocardial infarction:A report of two cases and review of the literature date: 2009-07-12 words: 2582 flesch: 47 summary: Maeder et al proposed pregnancy-related hypercholesterolemia as a contributory factor for pregnancy related coronary artery dissection (9). 12 Schiff JH, Gries A, Ehehalt R, Elsaesser M, Katus HA, Meyer FJ (2007).A pregnant woman with acute myocardial infarction due to coronary artery dissection: pre-hospital and in-hospital man- agement. keywords: artery; case; coronary; dissection; infarction; postpartum; pregnancy; risk cache: ujms-6590.pdf plain text: ujms-6590.txt item: #271 of 550 id: ujms-6594 author: Bennet, William ; Groth, Carl-Gustav ; Larsson, Rolf ; Nilsson, Bo ; Korsgren, Olle title: Isolated Human Islets Trigger an Instant Blood Mediated Inflammatory Reaction: Implications for Intraportal Islet Transplantation as a Treatment for Patients with Type 1 Diabetes date: 2000-07-12 words: 4161 flesch: 48 summary: An islet perfusion system was developed that 126 mimics the situation in vivo immediately after transplantation of islet cells into the portal vein and have used this system to examine the effect of whole blood upon transplanted islets. Other investigators have failed to detect complement activation by islets after exposure to human serum [8], despite the fact that islet cells do not express the complement regulatory proteins DAF (CD55) and MCP (CD46) and have only low amounts of protectin (CD59) (unpublished observations). keywords: activation; blood; cells; complement; ibmir; islets; patients; platelets; tissue; transplantation cache: ujms-6594.pdf plain text: ujms-6594.txt item: #272 of 550 id: ujms-6595 author: Lithell, Hans ; Sundström, Johan ; Ärnlöv, Johan ; Björklund, Kristina ; Hänni, Arvo ; Hedman, Anu ; Zethelius, Björn ; Byberg, Liisa ; Kilander, Lena ; Reneland, Richard title: Epidemiological and Clinical Studies on Insulin Resistance and Diabetes date: 2000-07-12 words: 7598 flesch: 56 summary: Upsala J Med Sci 105: 2, 135-150,2000 Epidemiological and Clinical Studies on Insulin Resistance and Diabetes Hans Lithell, Johan Sundstrom, Johan Amlov, Kristina Bjorklund, Arvo H h n i , Anu Hedman, Bjorn Zethelius, Liisa Byberg, Lena Kilander, Richard Reneland Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden ABSTRACT In Uppsala, extensive epidemiological and clinical studies on insulin resistance and diabetes have been ongoing for the past 30 years. At the first follow-up, when the men were 60 years old, insulin resistance was found to be a risk factor for development of hypertension and diabetes. keywords: blood; diabetes; glucose; hypertension; insulin; insulin resistance; men; pressure; resistance; sensitivity; study; ventricular cache: ujms-6595.pdf plain text: ujms-6595.txt item: #273 of 550 id: ujms-6596 author: Vessby, Bengt ; Karlström, Brita ; Öhrvall, Margareta ; Järvi, Anette ; Anderson, Agneta ; Basu, Samar title: Diet, Nutrition and Diabetes Mellitus date: 2000-07-12 words: 4409 flesch: 53 summary: These enzymes are today recognized to be at least partly regulated by dietary fatty acids (5). The preliminary results indicate for the first time that a change of dietary fatty acids from more saturated to more monounsaturated fatty acids is as- sociated with improved insulin sensitivity in humans (24). keywords: acid; diabetes; dietary; fatty; insulin; mellitus; nutrition; sensitivity; study; vessby cache: ujms-6596.pdf plain text: ujms-6596.txt item: #274 of 550 id: ujms-6597 author: Terenius, Lars title: From Opiate Pharmacology to Opioid Peptide Physiology date: 2000-07-12 words: 6611 flesch: 49 summary: Terenius, L. Families of opioid peptides and classes of opioid receptors. Evans, C.J., Keith Jr., D.E., Morrison, H., Magendzo, K. & Edwards, R.H. Cloning of a delta opioid receptor by fhnctional expression. keywords: activity; analgesic; brain; chronic; csf; dynorphin; endorphin; enkephalin; morphine; naloxone; opiate; opioid; pain; patients; peptides; receptor; terenius cache: ujms-6597.pdf plain text: ujms-6597.txt item: #275 of 550 id: ujms-6598 author: Markström, Agneta ; Hedlund, Anders ; Lichtwarck-Aschoff, Michael ; Nordgren, Anders ; Sjöstrand, Ulf title: Impact of Different Inspiratory Flow Patterns on Arterial CO2-tension date: 2000-07-12 words: 4695 flesch: 57 summary: 19 Recruitment Immediately after lavage, the surfactant depleted lungs were recruited with I:E 1: 1 and the external PEEP was set to 25 cmH,O and with a tidal volume to produce a peak inspiratory pressure (PIP) of 50 cmH20 during cyclic ventilation for 5 min. Ventilatory settings A Servo Ventilator 300 (Siemens-Elema AB, Solna, Sweden) provides both Volume Controlled ventilation (VC; constant inspiratory flow) and Pressure-Regulated Volume Controlled ventilation (PRVC; decelerating inspiratory flow). The animals were then assigned to either decelerating or constant inspiratory flow without EIP at 24 or 12 bpm, or to constant inspiratory flow at 12 bpm with an E P of 25% added . keywords: bpm; eip; end; flow; pause; pressure; time; ventilation; volume cache: ujms-6598.pdf plain text: ujms-6598.txt item: #276 of 550 id: ujms-6599 author: Willén, Roger ; Carlén, Birgitta ; Wang, Xin ; Papadogiannakis, Nicos ; Odselius, Rolf ; Wadström, Torkel title: Morphologic Conversion of Helicobacter Pylori from Spiral to Coccoid Form: Scanning (SEM) and Transmission Electron Microscopy (TEM) Suggest Viability: Scanning (SEM) and transmission electron microscopy (TEM) suggest viability date: 2000-07-12 words: 3446 flesch: 62 summary: 20.Khin, M.M., Ringner, M., Aleljung, P., Wadstrom, T., Ho, B.: Binding of human plasmino- gen and lactofemn by helicobacter pylori coccoid forms. Scanning electron microscopy (SEM) demonstrates coccoid form of bacteria with slightly ruffled surfaces but no spiral forms. keywords: bacteria; coccoid; fig; form; h.pylori; helicobacter; pylon; pylori; spiral cache: ujms-6599.pdf plain text: ujms-6599.txt item: #277 of 550 id: ujms-6601 author: Darj, Elisabeth ; Stålnacke, Boel title: Very Early Discharge from Hospital after Normal Deliveries date: 2000-07-12 words: 3616 flesch: 60 summary: Gagnon, A,, Edgar, L., Kramer, M., Papageorgiou, A., Waghorn, K. & Klein, M.: A ratidomised trial of a program of early postpartum discharge with nurse visitation. Few studies have examined the incidence of breast-feeding, comparing early discharged women with those in regular care. keywords: breast; care; discharge; feeding; home; hospital; women cache: ujms-6601.pdf plain text: ujms-6601.txt item: #278 of 550 id: ujms-6602 author: Hellström, Hans-Olov ; Lindh, Ulf ; Mjöberg, Bengt title: Measurement Accuracy of Aluminium Content in Bone date: 2000-07-12 words: 1882 flesch: 65 summary: We therefore determined the means and the coefficients of variation (i.e. SD/mean) of the aluminiudweight-quotient for wet bone, dry bone and bone ash, respectively, and of the aluminiudcalcium-weight-quotient in bone samples from one patient to determine the accuracy of measurement of the aluminium content in bone. Bone aluminium content in Alzheimer’s disease. keywords: aluminium; ash; bone; content; quotient; samples; weight cache: ujms-6602.pdf plain text: ujms-6602.txt item: #279 of 550 id: ujms-6610 author: Yokota, Takashi; Iwamoto, Kazutsugu; Kunn, Yasuo; Yamauchl, Hideml title: Malignant Fibrous Histiocytoma: A Method to Control Intraoperative Hemorrhage by Clamping the Feeding Arteries date: 2010-01-18 words: 1670 flesch: 56 summary: Retroperitoneal malignant fibrous histiocytoma. INTRODUCTION Malignant fibrous histiocytoma (MFH) is the most common adult soft tissue sarcoma (3, 8, 12, 14, 20), comprising 10% to 21% of all such tumors (16, 17). keywords: histiocytoma; left; mass; retroperitoneal; tumor cache: ujms-6610.pdf plain text: ujms-6610.txt item: #280 of 550 id: ujms-6615 author: Larsson, Anders ; Flodin, Mats ; Kollberg, Hans title: Increased Serum Concentrations of Carbohydrate-Deficient Transferrin (CDT) in Patients with Cystic Fibrosis date: 1998-12-31 words: 2046 flesch: 57 summary: We have studied S-CDT values in cystic fibrosis (CF) patients and show that CF patients have increased S-CDT values without high alcohol consumption. CF patients have abnormalities in their protein glycosylation and sialylation, which may explain the increased S-CDT values. keywords: alcohol; carbohydrate; cdt; patients; serum; transferrin cache: ujms-6615.pdf plain text: ujms-6615.txt item: #281 of 550 id: ujms-6624 author: El-Salhy, M. ; Mahdavi, J. title: Image Analysis of the Duodenal Endocrine Cells in Mice with Particular Regard to Optical Densitometry date: 1997-09-03 words: 2366 flesch: 54 summary: The number of endocrine cells/mm3 epithelial cells was estimated and the cell secretory index (CSI) for different endocrine cell types was determined. Using QUIPS, an automated standard sequence operation was created to measure the optical density in different endocrine cell types. keywords: analysis; cells; crypts; density; endocrine; image; villi cache: ujms-6624.pdf plain text: ujms-6624.txt item: #282 of 550 id: ujms-6625 author: Mallon, Lena ; Hetta, Jerker title: A Survey of Sleep Habits and Sleeping Difficulties in an Elderly Swedish Population date: 1997-07-23 words: 5251 flesch: 65 summary: Subjects living alone did not report sleep problems more frequently than those living with someone else, and no relationship was found between reported sleep problems and coffee or tea consumption, smoking habits or body mass index (BMI). Sleep problems were reported by 23.8% of females and 13.3% of males. keywords: complaints; depression; females; insomnia; prevalence; problems; sleep; sleeping; study; subjects; years cache: ujms-6625.pdf plain text: ujms-6625.txt item: #283 of 550 id: ujms-6626 author: Johnsson, H. ; Heldin, P. ; Sedin, G. ; Laurent, T. C. title: Hyaluronan Production in vitro by Fetal Lung Fibroblasts and Epithelial Cells Exposed to Surfactants of N-acetylcysteine date: 1997-12-31 words: 3607 flesch: 56 summary: The aim of the present study was to determine whether addition of surfactant or N- acetylcysteine to cultures of fetal lung cells would affect their hyaluronan production. 206 DISCUSSION Our findings do not indicate that hyaluronan synthesis by fetal lung epithelial cells or fetal lung fibroblasts is stimulated by either artificial or natural surfactant in the concen- tration ranges 5 pg/mL - 40 mg/mL, and 5 pg/mL - 20 mg/mL, respectively. keywords: acetylcysteine; cells; experiments; exposure; fibroblasts; hyaluronan; lung; medium; surfactant cache: ujms-6626.pdf plain text: ujms-6626.txt item: #284 of 550 id: ujms-6629 author: Roos, Magnus W. title: A Qualitative Study on Changes in Local Brain pH Due to Discrete Cerebral Microembolism date: 2010-01-18 words: 2714 flesch: 65 summary: Fisher, C. M.: Lacunar strokes and infarcts: A review. Fisher, C. M.: keywords: brain; cerebral; dmo; rabbits; stroke cache: ujms-6629.pdf plain text: ujms-6629.txt item: #285 of 550 id: ujms-6678 author: Ahn, Chul Min; Sandler, Håkan; Wegener, Thomas; Saldeen, Tom title: Effect of Indomethacin on Thrombin-Induced Pulmonary Edema in the Rat date: 2010-01-18 words: 3633 flesch: 57 summary: The reduced mean systemic artery pressure during the infusion of thrombin was slightly improved in the early phase after thrombin infusion by pretreatment with indomethacin. Pretreatment with indomethacin attenuated the increase in pulmonary artery pressure in the early phase after thrombin infusion. keywords: artery; increase; indomethacin; infusion; lung; mean; min; pressure; pulmonary; rats; thrombin; weight cache: ujms-6678.pdf plain text: ujms-6678.txt item: #286 of 550 id: ujms-6679 author: Dahlqvist, Monica title: The Significance of an Across-Shift Decrease in Vital Capacity—A Re-Analysis of a Study on Subjects Exposed to Diesel Exhaust date: 2010-01-18 words: 2581 flesch: 54 summary: Subjects with an across-shift decrease in vital capacity had a significantly greater across-shift decrease in residual volume and total lung capacity than subjects without an across-shift dccreasc in vital capacity. Total lung capacity was determined by planimetry, according to integration of the nitrogen wash-out curve as described by Buist and Ross (1). keywords: capacity; decrease; exposure; lung; shift; shift decrease; subjects cache: ujms-6679.pdf plain text: ujms-6679.txt item: #287 of 550 id: ujms-6681 author: Norlander, Staffan; Aste-Norlander, Ulnka; Nordgren, Bengt; Sahlstedt, Bo title: A Clinical Method for Measuring the Distribution of Segmental Flexion Mobility in the Cervico-Thoracic Spine date: 2010-01-18 words: 4140 flesch: 55 summary: A high correlation between vertebral flexion mobility and skin distraction was recognized individu- ally and for the whole group. The validity of the CTR-technique is dependent on a n individual and strong relationship between vertebral flexion mobility and skin distraction i n motion segments between C7 and TS. keywords: flexion; measuring; mobility; motion; repeatability; technique; tester cache: ujms-6681.pdf plain text: ujms-6681.txt item: #288 of 550 id: ujms-6685 author: Team, The UJMS Editorial title: The Life and Scientific Achievements of Torsten Teorell date: 2010-01-18 words: 101 flesch: 45 summary: Torsten Teorelll905 - 1992 Proceedings from a Symposium to commemorate The Life and Scientific Achievements of TORSTEN TEORELL On the 4th of August 1992 professor Torsten Teorell died a t the age of 87 after a very active scientific career leading to significant contributions to physiology. On the 11th of December 1992 the Department of Physiology at Uppsala University arranged a small symposium t o commemorate some of Torsten Teorell's extensive scientific work and during this symposium six papers were presented. keywords: teorell cache: ujms-6685.pdf plain text: ujms-6685.txt item: #289 of 550 id: ujms-6686 author: H:son Holmdahl, Martin title: Torsten Teorell, the Teacher and Researcher date: 2010-01-18 words: 1812 flesch: 46 summary: Professor Teorell was diligently working Iate at night in his own laboratory. Let us rather say that we have gathered in grateful remembrance of what Teorell meant to students of all levels within the medical faculty of Uppsala as a teacher, researcher and friend during more than half a century of busy activity and for each and every one of us as it relates to our own development. keywords: medical; physiology; research; teacher; teorell cache: ujms-6686.pdf plain text: ujms-6686.txt item: #290 of 550 id: ujms-6687 author: Öbrink, Karl Johan title: A Short Survey of the Scientific Work of Torsten Teorell date: 2010-01-18 words: 2668 flesch: 57 summary: His second examiner (according t o the Swedish system) was Ulf von Euler, who quite recently had defended his own thesis and the third examiner was a friend, Torsten h t r o m . His dream was t o become a mining engineer. keywords: acid; diffusion; fig; gastric; membrane; teorell cache: ujms-6687.pdf plain text: ujms-6687.txt item: #291 of 550 id: ujms-6688 author: Wolgast, M. title: Charge Structure of the Glomerular Capillary Membrane date: 2010-01-18 words: 3499 flesch: 61 summary: Suieden In 1935 Teorell (see Teorell, 1953,1983) presented his theory about charged membranes; the title of the paper was An attempt to formulate a quantitative theory of membrane permeability. Teorell also considered the electro-osmotic force resulting from the presence of an electric field in charged membranes, a consideration which later would form the basis of the so called membrane oscillator (Teorell, 1983). keywords: capillary; charge; field; fluid; gel; membrane; pressure cache: ujms-6688.pdf plain text: ujms-6688.txt item: #292 of 550 id: ujms-6689 author: Marsden, N.V.B. title: Red Blood Cells, Phase Contrast, Interference Contrast Microscopy and Microspectrophotometry date: 2010-01-18 words: 3174 flesch: 55 summary: Teorell (1) had shown that hemolysing erythrocytes are able to reseal, and t h e most plausible explanation for the dextran effect is that t h e hemolysing cells containing a mixture of Hb and dextran are able to reach colloid osmotic equilibrium with the external solution, and at some point resealing presumably occurs in the absence of a swelling pressure and with some Hb still retained. In this way dextran reduces the hemoglobin loss in hypotonic hemolysis. keywords: cells; dextran; erythrocytes; fig; hemolysis cache: ujms-6689.pdf plain text: ujms-6689.txt item: #293 of 550 id: ujms-6690 author: Paalzow, Lennart K. title: Torsten Teorell, the Father of Pharmacokinetics date: 2010-01-11 words: 5022 flesch: 112 summary: i n t e r p r e t a t t h e i n t e r e s t of t h e p h y s keywords: e t; n t cache: ujms-6690.pdf plain text: ujms-6690.txt item: #294 of 550 id: ujms-6691 author: Teorell, Eva title: A Daughter's Reflections upon her Father's Creativity date: 2010-01-18 words: 2700 flesch: 58 summary: When, in the autumn, we relatives went through father's possessions, I found one of his old slide-rules in a drawer, and for a long time I sat in meditation about this simple b u t ingenious little object, which was one of t h e most important mathematical tools of his generation. Father’s own imagination was such a completely spontaneous asset to him t h a t I believe it belonged t o one of the few phenomena of nature upon which h e never reflected. keywords: father; life; time; way cache: ujms-6691.pdf plain text: ujms-6691.txt item: #295 of 550 id: ujms-6693 author: Gowans, Elizabeth M.S. ; Hyltoft Petersen, Per ; Blaabjerg, Ole title: Analytical Quality Specifications date: 1994-12-31 words: 1422 flesch: 40 summary: Based on the concepts of sharing common reference intervals and of allowing for analytical bias and imprecision instead of uncertainty from samples size it is possible to estimate analytical quality specifications for all endogenous quantities. In consequence the future may show a general and more informed attitude to the question of transferability of data and, thereby, also to the development and use of common reference intervals. keywords: intervals; quality; reference; specifications cache: ujms-6693.pdf plain text: ujms-6693.txt item: #296 of 550 id: ujms-6695 author: Blirup-Jensen, S. ; Just Svendsen, P. title: A New International Reference Preparation for Proteins in Human Serum date: 1994-07-19 words: 2318 flesch: 46 summary: During the past 10 years a large number of reference materials for serum proteins have been used worldwide. A new approach was developed for the value assignment to serum protein preparations (13). keywords: crm; material; preparation; protein; reference; serum; transfer; values cache: ujms-6695.pdf plain text: ujms-6695.txt item: #297 of 550 id: ujms-6697 author: Blaabjerg, Ole ; Blom, Mogens ; Hyltoft Petersen, Per ; Uldall, Adam ; Gry, Hanne title: Preparation of the Nordic Protein Calibrator date: 1994-07-19 words: 2039 flesch: 58 summary: Discussion It has been discussed for a long time whether protein calibrators should be frozen liquid or lyophilized, and how the delipidation should be performed. t t t keywords: proteins cache: ujms-6697.pdf plain text: ujms-6697.txt item: #298 of 550 id: ujms-6698 author: Blaabjerg, Ole ; Blom, Mogens ; Icén, Arto ; Irjala, Kerttu ; Carlström, Anders ; Hyltoft Petersen, Per title: Transfer of Values from BCR 470 to the Nordic Protein Calibrator date: 1994-07-19 words: 1256 flesch: 53 summary: Transfer of concentration values IFCC has set up a protocol for correct transfer of values from IFCC/CAP/BCR 470 to any secondary calibrator (chapter 5.2) and the transfer was performed in five Nordic laboratories according to this protocol. 20 % higher than the others, and has been omitted from the calculations of mean The measurements of target values for Haptoglobin and Transferrin are very precise with CV-values close to 0.5 %, and for Orosomucoid with approx. keywords: chemistry; department; transfer; values cache: ujms-6698.pdf plain text: ujms-6698.txt item: #299 of 550 id: ujms-6699 author: Blaabjerg, Ole ; Kragh Olesen, Thea ; Hyltoft Petersen, Per title: Evaluation of Target Values for α1-Antitrypsin date: 1994-07-19 words: 1426 flesch: 52 summary: Minor differences can, however, be seen as measurements on the BNA of fresh sera results in a difference of approx. Analytical principle * Antisera Q Structure of al-Antitrypsin in the two calibrators Therefore, a comparison to fresh human sera was decided with a design where both calibrators were measured according to the two analytical principles using both antisera. keywords: calibrator; crm; fresh cache: ujms-6699.pdf plain text: ujms-6699.txt item: #300 of 550 id: ujms-6700 author: Hyltoft Petersen, Per ; Blaabjerg, Ole ; Irjala, Kerttu ; Icén, Arto ; Bjøro, Kristian title: The Nordic Protein Project date: 1994-07-19 words: 7201 flesch: 57 summary: Control C Control A accept limit i ........... Interference is defined as modification of the signal t o be measured, and a variety of blood substances are interfering with the protein molecules and, thereby, modifying the signal - but for healthy individuals this effect is assumed t o be comparable in all samples and therefore, negligible for the investigations in this project. keywords: analytical; bias; calibrator; control; fig; intervals; principles; project; quality; reference; results; turbidity; values cache: ujms-6700.pdf plain text: ujms-6700.txt item: #301 of 550 id: ujms-6701 author: Hyltoft Petersen, Per ; Blaabjerg, Ole title: Reference Intervals for Plasma Proteins: Principles for Estimation of Reference Intervals date: 1994-07-19 words: 1955 flesch: 64 summary: For reference intervals the most relevant transformation of data is to take the logarithm, as many laboratory reference values are distributed close to log- Gaussian. Upsala J Med Sci 99: 307-314, 1994 7. Reference Intervals for Plasma Proteins 7.1 Principles for Estimation of Reference Intervals Per Hyltoft Petersen and Ole Blaabjerg Department of Clinical Chemistry, Odense University Hospital, DK-5000 Odense C, Denmark 7.1.1 Models f o r Estimation of Reference Intervals Models for estimation of reference intervals are either parametric or non-parametric and both have advantages and disadvantages. keywords: group; intervals; reference; values; women cache: ujms-6701.pdf plain text: ujms-6701.txt item: #302 of 550 id: ujms-6702 author: Blaabjerg, Ole ; Nørgaard, Inger ; Blom, Mogens ; Rahbek Nørgaard, Jens ; Hyltoft Petersen, Per ; Gry, Hanne ; Uldall, Adam title: Reference Intervals Based on a Danish Population date: 1994-07-19 words: 6059 flesch: 62 summary: So often reference intervals are based on an insufficient number of poorly characterized reference indwiduals or they are transferred from an old to a new analytical method when a new equipment, a new calibrator, or a new analytical principle is introduced in the laboratory - without the needed investigations. Comparison of reference intervals and results from a n external control survey i n Denmark in 1990 for S-IgM. keywords: age; distributions; fig; intervals; reference; women cache: ujms-6702.pdf plain text: ujms-6702.txt item: #303 of 550 id: ujms-6703 author: Lund, Erik ; Blaabjerg, Ole ; Blom, Mogens ; Hyltoft Petersen, Per ; Rahbek Nørgaard, Jens ; Uldall, Adam ; Gry, Hanne ; Brandslund, Ivan title: Reference Intervals for α1-Antitrypsin date: 1994-07-19 words: 1680 flesch: 62 summary: 99 - 95 - 90 - 80 - 70 - 60 - 50 - 40 - 30 - 20 - 10 - 5 - 1 - Cumulated percentage frequency PROBIT MZ MS MM MM Discussion The limitations for evaluation of S-al-Antitrypsin are the same as for the other eight proteins (cf. chapter 7.2) but, in addition the separation into phenotypes MM, MS, and MZ (and others) reduces the number of individuals in the subgroups. keywords: antitrypsin; reference cache: ujms-6703.pdf plain text: ujms-6703.txt item: #304 of 550 id: ujms-6704 author: Irjala, Kerttu ; Matinlauri, Irma ; Mattila, Kari ; Blaabjerg, Ole ; Blom, Mogens ; Hyltoft Petersen, Per ; Rahbek Nørgaard, Jens ; Gry, Hanne ; Uldall, Adam ; Nørgaard, Inger title: Comparison between Finnish and Danish Reference Values for Plasma Proteins date: 1994-07-19 words: 2364 flesch: 60 summary: Discussion The design of this comparison of plasma protein distributions between the Finnish and the Danish populations, was set up at a limited scale which could only disclose considerable differences with certainty. Distributions of S-Prealbumin values for the Finnish and Danish reference individuals with separate curves for the two sexes. keywords: danish; distributions; reference cache: ujms-6704.pdf plain text: ujms-6704.txt item: #305 of 550 id: ujms-6705 author: Blaabjerg, Ole ; Hyltoft Petersen, Per ; Blom, Mogens ; Irjala, Kerttu ; Uldall, Adam ; Gry, Hanne ; Mattila, Karla ; Matinlauri, Irma ; Lund, Erik ; Rahbek Nørgaard, Jens title: Common Reference Intervals for Plasma Proteins in the Nordic Countries date: 1994-07-19 words: 1655 flesch: 53 summary: So, the analytical prerequisites are available for establishing common reference intervals. The comparison between Finnish and Danish showed that in the Nordic countries it could be possible to establish common reference intervals for the seven proteins, with S-Haptoglobin and S-IgA as exceptions - and with the methodological exceptions for S- al-Antitrypsin (cf. section 7.3). keywords: intervals; proteins; reference cache: ujms-6705.pdf plain text: ujms-6705.txt item: #306 of 550 id: ujms-6706 author: Thye-Rønn, Peter ; Blaabjerg, Ole ; Hyltoft Petersen, Per title: Reference Intervals for Plasma Proteins in Patients with Non-Insulin Dependent Diabetes Mellitus date: 1994-07-19 words: 2356 flesch: 56 summary: When reference intervals are established based on a healthy reference population they may have limited application for clinical purposes, as the average age of the reference individuals often is different from the age of patients (6). The object of this investigation was primarily to establish reference intervals for nine selected plasma proteins in patients with non-insulin dependent diabetes mellitus, and secondly t o get informations which could evaluate the theory that cellular insulin defiency affects protein synthesis. keywords: age; population; reference cache: ujms-6706.pdf plain text: ujms-6706.txt item: #307 of 550 id: ujms-6707 author: Wiggers, Preben ; Dalhøj, Jørgen; Blaabjerg, Ole ; Hyltoft Petersen, Per title: Reference Intervals for Sedimentation Rate date: 1994-07-19 words: 471 flesch: 64 summary: Like all other reference intervals a fraction of 'defined healthy' individuals will be excluded due to test results outside the reference interval. 7.7.1 97% percentile for ESR as function of age for healthy men and women. keywords: sedimentation; women cache: ujms-6707.pdf plain text: ujms-6707.txt item: #308 of 550 id: ujms-6708 author: Olafsdottir, E. ; Hellsing, K. ; Steensland, H. ; Tenhunen, R. ; Uldall, A. title: Adding new scopes to traditional EQA schemes emphasizing Quality Improvement date: 1994-07-19 words: 2508 flesch: 52 summary: The longstanding work of Labquality in Finland has thoroughly recorded and published quality performance in Finnish laboratories as well as some more selected fields in other Nordic laboratories. In preparation of such a change the following elements have to be considered (i) Establishment of quality goals and desirable performance standards Following the initial Nordic Clinical Chemistry Project (NORDKEM) where quality requirements were assessed (1) it was recommended that each laboratory set their own quality goals and desirable performance standards. keywords: chemistry; clin; eqa; invest; lab; quality; scand cache: ujms-6708.pdf plain text: ujms-6708.txt item: #309 of 550 id: ujms-6709 author: Hyltoft Petersen, Per ; Blaabjerg, Ole ; Irjala, Kerttu title: Discussion and Conclusions date: 1994-07-19 words: 1510 flesch: 36 summary: The combined introduction in the project of analytical quality specifications related to the use of common reference intervals - and the co-ordination with projects which established these common reference intervals - was an important improvement of the total concept of the projects. On the other hand, the Nordic Protein Project may make the introduction of the IFCC reference-preparation easier, due to the advantages from the project and from the establishment of common reference intervals for the Nordic countries. keywords: intervals; project; protein; reference cache: ujms-6709.pdf plain text: ujms-6709.txt item: #310 of 550 id: ujms-6711 author: Larsson, Erik ; Andersson, Ann-Catrin ; Nilsson, B. Ove title: Expression of an Endogenous Retrovirus (ERV3 HERV-R) in Human Reproductive and Embryonic Tissues—Evidence for a Function for Envelope Gene Products date: 1994-07-19 words: 2847 flesch: 52 summary: Our conclusions concerning ERV3 env expression can be further substantiated by the fact that syncytiotrophoblasts, both in ovarian and testicular carcinomas, expressed ERV3 env. ERV3 %is highly expressed in certain cells i n spermatogenesis but not in the Sertoli or Leydig cells, and finally (d) ERV3 env is expressed in certain embryonic tissues such as the adrenal gland and nervous tissues. keywords: cells; env; erv3; expression; human; placenta; retroviruses; tissues cache: ujms-6711.pdf plain text: ujms-6711.txt item: #311 of 550 id: ujms-6712 author: Larsson, Anders ; Lindahl, Tomas L. title: Inhibition of Fibrinogen Binding to Platelets by MK-852, a New GPIIb/IIIa Antagonist date: 1994-07-19 words: 2948 flesch: 56 summary: 10 pa of MK-852 gave only a limited reduction in the percentage of fibrinogen positive platelets in comparison with only HEPES-buffer. The results are expressed as percentage of fibrinogen positive platelets in the presence of 100 pmoVL of ADP. keywords: activation; adp; antibodies; binding; fibrinogen; immune; mk-852; platelets; receptor cache: ujms-6712.pdf plain text: ujms-6712.txt item: #312 of 550 id: ujms-6715 author: Kreyberg Normann, Erik ; Evald, Uwe ; Dahl-Jørgensen, Knut ; Larsen, Stig ; Norman, Nils ; Tuvemo, Torsten title: Decreased Serum Insulin-like Growth Factor I during Puberty in Children with Insulin Dependent Diabetes Mellitus (IDDM) date: 1994-07-19 words: 2214 flesch: 65 summary: There was no difference between girls, but diabetic boys had higher mean serum concentration of growth hormone than controls (3.5 (4.8) vs. 1 . This deficiency seems to be connected to increased growth hormone concentrations at least in boys, which might be due to lack of negative feed back control. keywords: boys; children; controls; girls; growth; igf cache: ujms-6715.pdf plain text: ujms-6715.txt item: #313 of 550 id: ujms-6747 author: Elamin, Abdelaziz title: Goitre and Deaf-Mutism date: 1991-09-01 words: 2074 flesch: 63 summary: The occurrence of congenital deafness, mutism and goitre unassociated with cretinism or mental retardation in euthyroid patients is known as Pendreds Syndrome. It has been estimated that 4-10 % of children with congenital deafness suffer from this condition. keywords: deafness; defect; goitre; syndrome; thyroid cache: ujms-6747.pdf plain text: ujms-6747.txt item: #314 of 550 id: ujms-6754 author: Luostarinen, Riitta ; Siegbahn, Agneta ; Saldeen, Tom title: Effects of Dietary Supplementation with Vitamin E on Human Neutrophil Chemotaxis and Generation of LTB4 date: 1991-09-01 words: 3307 flesch: 56 summary: Upsala J Med Sci 96: 103-1 11, 1991 Effects of Dietary Supplementation with Vitamin E on Human Neutrophil Chemotaxis and Generation of LTB4 Riitta Luostarinen, Agneta Siegbahn’ and Tom Saldeen From the Departments of Forensic Medicine, University of Uppsala, Dag Hammarskjolds vag 17, S-752 37 Uppsala, Sweden and ‘Clinical Chemistry, University Hospital, S- 751 85 Uppsala, Sweden ABSTRACT Three weeks’ dietary supplementation with a moderate dose of vitamin E (45 IU DL-a-tocopherol acetate daily), in eight healthy volunteers significantly increased the serum vitamin E level from 12.3 k 3.3 to 16.2 & 3.7 mglL (means k SD) and significantly decreased neutrophil chemotaxis from 15 -+ 3 to 4 f 1 pm/h (means f standard error of the means). Vitamin E in serum After dietary supplementation with vitamin E for 3 weeks, the serum vitamin E level was increased to 16.2 L- 3.7 mg/L from an initial value of 12.3 k 3.3 mg/L (P < 0.001; keywords: calcium; chemotaxis; neutrophils; plasma; serum; supplementation; vitamin; vitamin e; weeks cache: ujms-6754.pdf plain text: ujms-6754.txt item: #315 of 550 id: ujms-6763 author: Wikblad, Karin ; Montin, Kent ; Wibell, Lars title: Metabolic Control, Residual Insulin Secretion and Self-care Behaviours in a Defined Group of Patients with Type 1 Diabetes date: 1991-09-01 words: 6631 flesch: 61 summary: A more aggressive treatment of hypertension in diabetes patients during the recent years could have contributed to the decrease, here observed, in the number of patients with albuminuria. Thus the study material was representative of type 1 diabetes patients 25-45 years old with a disease duration of 10-40 years, with two further possible selection factors to consider: 1) such patients would be lost as had died at a young age before 1984 or referred e.g. to dialysis 2) patients not steadily living in the Uppsala area but having left the city, or moved in, during the retrospective analysis period (1980-1984) would not be included. keywords: care; control; diabetes; group; hbalc; insulin; mean; patients; peptide; self; type; years cache: ujms-6763.pdf plain text: ujms-6763.txt item: #316 of 550 id: ujms-6774 author: Tryding, Nils title: Comments. Which Tests Should Be Decentralized to the Primary Health Care? date: 1990-09-01 words: 722 flesch: 54 summary: The present list of laboratory tests physicians would like to have performed locally according to clinical needs includes: B-Erythrocyte sedimentation rate (B-ESR) B-Hemoglobin (B-Hb) U-Albumin, U-Glucose (teststrips) (U-Hemoglobin, U-Acetoacetate, U-Nitrite teststrips) B-Glucose B-, U-Cells, microscopy B-Coagulation factors (Prothrombin complex) Pt-Bleeding time S-Potassium S-C-reactive protein (CRP) S-Creatinine S-ALAT, S-GT,S-ALP, S-Bilirubin, S-Amylase, S-Cat S-CKMB S-Cholesterol, fS-Triglycerides, B-HbAlc, S-Theophylline U-Dens ity 15 - 908573 225 U-A 1 bumi n U-Human Chorionic gonadotropin (U-hCG) F-Hemoglobin The list reflects present Swedish practice but varies locally. keywords: tests cache: ujms-6774.pdf plain text: ujms-6774.txt item: #317 of 550 id: ujms-6775 author: Fraser, C. G. title: Quality Specifications in Laboratory Medicine date: 1990-09-01 words: 900 flesch: 59 summary: If such information was available, current theories and knowledge on analytical and variation are sufficient to enable relevant quality goals to be set. Lytken Larsen MI Fraser CG, Hyltoft Petersen P. A compari- son of analytical goals for Haemoglobin Alc assays derived using different strategies. keywords: fraser; goals; quality cache: ujms-6775.pdf plain text: ujms-6775.txt item: #318 of 550 id: ujms-6776 author: Laessig, Ronald H. title: Medical Need for Quality Specifications within Laboratory Medicine date: 1990-09-01 words: 3418 flesch: 56 summary: other factors such as clerical errors, shipping problems, matrix effects, grading errors, etc., which can amount to 5 0 % of the apparent causes of PT failures should not be neglected, but a laboratory's analytical prowess is fundamental. INTRODUCTION The continuous and consistent improvement in the quality of laboratory results is well documented. keywords: analyte; bias; event; laboratory; performance cache: ujms-6776.pdf plain text: ujms-6776.txt item: #319 of 550 id: ujms-6777 author: Mellin, Lars title: General Administrative and Economical Aspects date: 1990-09-01 words: 1004 flesch: 53 summary: The approach I have described, although done on a very general level, is essential also to understand the role and position of every part of health care services, as laboratory medicine, in the health care system as a national entity and in the overall producing of high standard and optimal services. Local authorities (460 in 1989) are mainly responsible for producing health care services. keywords: care; health; services cache: ujms-6777.pdf plain text: ujms-6777.txt item: #320 of 550 id: ujms-6778 author: de Verdier, Carl-Henric title: Comments. Aspects of Administration and Economical Planning of Clinical Laboratories in Sweden date: 1990-09-01 words: 238 flesch: 41 summary: Aspects of Administration and Economical Planning of Clinical Laboratories in Sweden Carl-Henric de Verdier Department of Clinical Chemistry, University of Uppsala, Uppsala, Sweden The tendency towards decentralization and delegation of economi- cal responsibility is very clear also in Sweden in health care organization in general and in clinical laboratories in particu- lar. In many administrative areas for health care - counties - it is planned from 1991 or 1992 not to give the clinical chemical laboratories a fixed annual budget but to distribute economical resources to the clinics and the primary care districts and let them buy laboratory services according to a predetermined price- list. keywords: laboratories cache: ujms-6778.pdf plain text: ujms-6778.txt item: #321 of 550 id: ujms-6779 author: Hyltoft Petersen, P. ; Blaabjerg, O. ; Bjøro, K. ; Icén, A. ; Irjala, K . title: The Nordic Protein Project date: 1990-09-01 words: 1134 flesch: 54 summary: Other analytical quality specifications e.g. related to the use of serum proteins in defined clinical strategies, may be evaluated in co- operation with this 'umbrella project' on 'Medical need for quality specifications in laboratory medicine'. The co-ordinated projects on reference intervals in Denmark and Finland are planned to supply the laboratories with common reference intervals by May and September 1990, respectively. keywords: control; intervals; quality; reference cache: ujms-6779.pdf plain text: ujms-6779.txt item: #322 of 550 id: ujms-6780 author: Ruokonen, A. ; Hyltoft-Petersen, P. ; Blaabjerg, O. title: External Quality Assurance Model for Improvement of Specificity and Assuracy of Serum Hormone Determinations in the Nordic Countries date: 1990-09-01 words: 461 flesch: 49 summary: Control material (quality assurance samples and the calibrator) is frozen human serum and its T, and C concentrations have been determined by GC-MS. Quality assurance samples are used to evaluate specificity and calibration bias (at three concentration levels) of the analytical method of each laboratory. keywords: assurance; quality cache: ujms-6780.pdf plain text: ujms-6780.txt item: #323 of 550 id: ujms-6781 author: Olafsdottir, Elin ; Aronsson, Torsten ; Groth, Torgny ; de Verdier, Carl-Henric title: The Regional Transferability Project date: 1990-09-01 words: 230 flesch: 29 summary: Analytical stability estimated over different time periods from slope and intercept of regression lines are of different degree of acceptability. Steps to reduce the interlaboratory variability will be suggested and the investigation will be extended in order to study the possibility to use transformation functions for transfer of data by collection of data from e g reference populations with defined condition of health from different geographical areas. keywords: uppsala cache: ujms-6781.pdf plain text: ujms-6781.txt item: #324 of 550 id: ujms-6782 author: Hyltoft Petersen, P. ; de Verdier, Carl-Henric title: Quality Specifications date: 1990-09-01 words: 919 flesch: 42 summary: Analytical quality specifications Cost+ The needs for analytical quality are different for various clinical situations as demonstrated for TSH- measurements, where the quality needed for basal S-TSH determinations used 'to predict S-TSH response to TFU-II is extremely demanding (7), whereas the requirements for B-TSH measurements in screening for congenital hypothyroidism are very loose ( 8 ) . keywords: bias; quality; specifications cache: ujms-6782.pdf plain text: ujms-6782.txt item: #325 of 550 id: ujms-6783 author: Groth, Torgny title: Some Methodological Aspects on Quality Assurance in Laboratory Medicine date: 1990-09-01 words: 2207 flesch: 51 summary: 265 PRACTICAL USE OF ANALYTICAL QUALITY SPECIFICATIONS Considering the diversity of approaches advocated for assessing analytical quality specifications, and the circumstance that any quality specification of laboratory results will only be temporary (1) , the right thing to do would be to set up a first provisional IfNordic List as a starting point to a coordinated learning and teaching process on how to apply such quality specifications in practice. Analytical quality specifications expressed as allowable analytical errors (AAE) at specified concentration levels or ranges should then be applied for: 1. keywords: analytical; groth; knowledge; laboratory; quality; test cache: ujms-6783.pdf plain text: ujms-6783.txt item: #326 of 550 id: ujms-6784 author: de Verdier, Carl-Henric title: Plans for Obtaining a “NORDIC LIST” of Specifications date: 1990-09-01 words: 793 flesch: 43 summary: The list of quality specifications must be structured around: System--Component, Testing/evaluation of different methods/investigations Clinical situations (concentration ranges) Type of quality specification: 1) Clinical Needs 2) Clinical Quality Specifications 3 ) Also other ways of calculating clinical needs and clinical quality specifications - using e g decision analysis or biomedical models (see chapter 3 ) - are of interest. keywords: list; quality; specifications cache: ujms-6784.pdf plain text: ujms-6784.txt item: #327 of 550 id: ujms-6785 author: Nilsson-Ehle, Peter title: Measuring Cholesterol A Handbook for Out-Patient Clinics and Laboratory Personnel date: 1990-09-01 words: 1635 flesch: 43 summary: Instructions given to the subjects before sampling, in order to minimize biological variation, include abstinence from alcohol the day before sampling, since alcohol intake may markedly increase lipid levels. The differentiation between analytical error, sampling error and biological variation is necessary to accurately evaluate the contribution of these sources of variation to the total variation of the cholesterol measurement. keywords: cholesterol; sampling; screening; variation cache: ujms-6785.pdf plain text: ujms-6785.txt item: #328 of 550 id: ujms-6786 author: Penttilä, I. M. ; Puhakainen, E. ; Ryynänen, M. title: Selecting a Sensitive Immunoradiometric Method of Maternal Serum Alphafetoprotein for Prenatal Screening of Abnormalities in the Fetus date: 1990-09-01 words: 1205 flesch: 60 summary: The use of a sensitive alpha-fetoprotein method and low maternal serum value in the screening of trisomies during the second trimester of pregnancy. The corresponding discrimination limits for high values in amniotic fluid were: means + 5 * S.D. and means O+ 10 * S.D., the highest one indicating a very probable abnormality in the fetus . keywords: afp; serum; values cache: ujms-6786.pdf plain text: ujms-6786.txt item: #329 of 550 id: ujms-6787 author: Penttilä, I. ; Gävert, J. ; Julkunen, A. ; Tantanen, T. title: Quality Control and Quality Requirements for the Measurement of Glycated Hemoglobin date: 1990-09-01 words: 1343 flesch: 55 summary: Many methods have been developed, but its seems quite evident that the HPLC-methods which measure the proportion of glycated hemoglobin Alc (GHbAlc) or the affinity chromatography measuring all glycated forms of hemoglobin (GHb) are the most useful for the routine clinical laboratory work (1,2,3,5). Different methods used by participating laboratories in the the surveys of Labquality Ltd. for the determination of glycated hemoglobins and they reference intervals Method Component Reference measured intervals Isoelectric focusing GHbAlc 4.0 - 6.5 % HPLCIFPLC ionex chromat. keywords: control; edta; ghbalc; hemoglobin; hemolysate cache: ujms-6787.pdf plain text: ujms-6787.txt item: #330 of 550 id: ujms-6788 author: Team, UJMS title: List op Planned Associated Projects in the NORDKEM Project 5/89 on Medical Need for Quality Specifications in Laboratory Medicine date: 1990-09-01 words: 501 flesch: 74 summary: ParticiDants Title Hqrder M,Olivarius N, Jqrgensen PJ, Diabetes in Primary Bihlet I, Hyltoft Petersen P Fraser C, Hyltoft Petersen P Antonsen S Grodum E, Hyltoft Petersen P, Hangaard J, Bollerslev J et al. Djurhus S, Rohold A, Vadstrup S, Hyltoft Petersen P Magid E, Hyltoft Petersen P Dybkaer R , Hyltoft Petersen P, de Verdier C-H et al. 23. keywords: petersen; qual; spec cache: ujms-6788.pdf plain text: ujms-6788.txt item: #331 of 550 id: ujms-6789 author: Groth, Torgny ; Hyltoft Petersen, Per ; de Verdier, Carl-Henrik title: Summing up date: 1990-09-01 words: 805 flesch: 48 summary: An important continuation of this process is to find ways for obtaining the specified quality, whether they are instructions for reducing preanalytical variations or guidelines for improving analytical quality etc. Production of analytical results is the predominant function of the clinical chemical laboratory and analytical quality control and analytical quality assurance are therefore major tasks for this type of laboratory. keywords: clinical; laboratory; quality cache: ujms-6789.pdf plain text: ujms-6789.txt item: #332 of 550 id: ujms-6790 author: of Medical Sciences, Upsala Journal title: Glossary of Terms date: 1990-09-01 words: 776 flesch: 53 summary: Analytical Quality Specifications allowable analytical error (AAE) = total allowable error (TE,) = Analytical Quality Goal. 20- 908573 305 increase in random error (RE). keywords: quality; quantity; value cache: ujms-6790.pdf plain text: ujms-6790.txt item: #333 of 550 id: ujms-6791 author: for the NORDKEM-project, The project group title: Acknowledgement date: 1990-09-01 words: 145 flesch: 51 summary: It is a pleasure also to acknowledge Mrs Anette Marcusson, Department of Clinical Chemistry, University Hospital, Upp- sala, who with efficiency and accuracy prepared the manu- scripts for printing and Mrs Sinikka Savolainen who delt with the project at the NORDKEM office in Helsinki. The project group wants to express its thanks to Mrs Gunilla Stromstedt, Department of Clinical Chemistry, University of Uppsala for secreterial help and for practical organization of the Seminar at Friibergh's herrgdrd, Bro on April 23 - 2 4 1990. keywords: project cache: ujms-6791.pdf plain text: ujms-6791.txt item: #334 of 550 id: ujms-6792 author: Berglund, Lars title: Transplacental Amino Acid Transfer and its Study Using Positron Emission Tomography: A short review based on a doctoral thesis date: 1990-09-01 words: 9634 flesch: 55 summary: 43.Penfold, P., Illsley, N. P., Purkiss, P. & Jennings, P.: Human placental amino acid transfer and metabolism in oxygenated and anoxic conditions. Methods for placental transfer studies In vitro studies of placental tissue and fragments. keywords: acid; amino; amino acid; blood; foetal; foetus; human; methionine; pet; placental; placental transfer; radioactivity; studies; transfer; transport; uptake cache: ujms-6792.pdf plain text: ujms-6792.txt item: #335 of 550 id: ujms-6794 author: Lagerqvist, Bo ; Sylvén, Christer ; Helmius, Gunnar ; Waldenström, Anders title: Effects of Exogenous Adenosine in a Patient with Transplanted Heart. Evidence for Adenosine as a Messenger in Angina Pectoris date: 1990-09-01 words: 2603 flesch: 56 summary: 10 Sylven C., Beermann B., Jonzon B. & Brandt R.: Angina pectoris-like pain provoked by intravenous adenosine in healthy volunteers. After intravenous injection no pain was provoked in the chest or in adjacent structures. keywords: adenosine; coronary; heart; injection; pain; patient; reference cache: ujms-6794.pdf plain text: ujms-6794.txt item: #336 of 550 id: ujms-6795 author: Karlsson, Mats G. ; Eriksson, Ulf J. ; Swenne, Ingemar title: Perinatal Hypoadrenalism in the Rat does not Alter Glucose Tolerance and Insulin Secretory Response to Glucose date: 1990-09-01 words: 2979 flesch: 58 summary: Effect of metyrapone treatment of rats during pregnancy and lactation on the glucose tolerance and insulin secretory response to glucose in the offspring. The 152 present finding of lowered serum and pancreatic insulin con- centrations could be interpreted to indicate a hypoplasia of the islet organ in the neonates with hypoadrenalism. keywords: day; glucose; insulin; metyrapone; mothers; rat; serum; weight cache: ujms-6795.pdf plain text: ujms-6795.txt item: #337 of 550 id: ujms-6796 author: Lind, L. ; Ljunghall, S. title: Hypercalcemia in Pulmonary Tuberculosis date: 1990-09-01 words: 1131 flesch: 53 summary: After one month of treatment serum calcium levels had decreased to 2.45 f 0.1 1 (p<0.05) and a further reduction to 2.39 f 0.10 mmol/l was seen at the end of chemotherapy (pe0.01, see figure). Davies, P.D.O., Church, H.A., Brown, R.C. & Woodhead, J.S.: Raised serum calcium in tuberculosis patients in Africa. keywords: calcium; patients; serum; tuberculosis cache: ujms-6796.pdf plain text: ujms-6796.txt item: #338 of 550 id: ujms-6797 author: Rasmussen, Carsten title: Hyperprolactinaemia—A Clinical Study with Special Reference to Long-term Follow-up, Treatment with Dopamine Agonists, and Pregnancy date: 1990-09-01 words: 17320 flesch: 92 summary: i s J.L., P e r r y m a n R.L., C o n w a y B.P., H o w a r d s S.S., W o l f m a n M.G. & M a c L e o d R.M. i t y of o e s t r o g e n f e e d b a c k in a m e n o r r h o e a g a l keywords: c t; e c; e e; e l; e m; e n; e r; e t; n c; n d; n s; n t; o l; o n; r n; r o; r t; s e cache: ujms-6797.pdf plain text: ujms-6797.txt item: #339 of 550 id: ujms-6798 author: Styrud, Johan ; Unger, Erik ; Eriksson, Ulf J. title: Metabolism in Vitro of Cartilage Proteoglycans in Rat (Pre)chondrocytes from Different Embryonic Regions date: 1990-09-01 words: 3834 flesch: 61 summary: In limb bud cultures the ratio was 1 :6, whereas in mandibular arch culture the ratio was approximately 1 :1 (Table 2). Hassel, J. R., Pennypacker, J. P A Lewis, C. A.: Chondrogenesis and cell pro- liferation in limb bud cell cultures treated with cytosine arabinoside and vitamin A. Exp cell res 1 12:409-417, 1978. keywords: arch; bud; cells; chondrocytes; culture; glucose; limb; medium; peak; proteoglycans; rats cache: ujms-6798.pdf plain text: ujms-6798.txt item: #340 of 550 id: ujms-6799 author: Malmberg, Per ; Hillerdal, Gunnar title: Association between Exposure to Asbestos and Pleural Effusion. Results from a Questionnaire Study of 31000 Persons date: 1990-09-01 words: 2926 flesch: 65 summary: Men who had indicated exposure to asbestos also reported having suffered from pleurisy more than twice as often as men who did not report asbestos exposure. This association between asbestos exposure and pleurisy was, however, f keywords: age; asbestos; exposure; fig; men; smokers cache: ujms-6799.pdf plain text: ujms-6799.txt item: #341 of 550 id: ujms-6830 author: Möller, Bo ; Lushino, Omari ; Kabukoba, Josephat ; Kavishe, Festo ; Gebre-Medhin, Mehari ; Meirik, Olav ; Lindmark, Gunilla title: A Prospective Area-based Study of the Outcome of Pregnancy in Rural Tanzania date: 1989-09-01 words: 3141 flesch: 70 summary: In singleton pregnancy birth weight for gestational age under optimal conditions increases in a linear fashion (17). Table 1 shows birth weight specific mortality with unweighed infants separately. keywords: birth; mortality; perinatal; pregnancy; rate; tanzania; weeks; weight cache: ujms-6830.pdf plain text: ujms-6830.txt item: #342 of 550 id: ujms-6831 author: Solberg, Christel title: Storage of Human Red Blood Cells and Platelets: Some aspects concerning the factors leading to storage lesion characterized as morphological changes and vesiculation. Minireview based on a doctoral thesis date: 1988-09-01 words: 6876 flesch: 61 summary: Blood, 65, 52 Deniel, R.A., Geurtz van Kessel, W.S.M., Zwaal, R.F.A., Roelofsen, B., van Deenen, L.L.M. (1975) Relation between various phospholipase actions on human red cell membranes and the interfacial phospholipid pressure in monolayer. Reinhart, W.H., Chien, S. (1987) Echinocyte-stomatocyte transformation and shape control of human red blood cells: Morphological aspects. keywords: activation; atp; bags; blood; cell; changes; erythrocyte; generation; membrane; phospholipids; platelet; red; shape; spectrin; storage cache: ujms-6831.pdf plain text: ujms-6831.txt item: #343 of 550 id: ujms-6834 author: Kindmark, Claes-Otto ; Laurell, Carl-Bertil ; Iwarson, Sten ; Person, Kennet title: Sequential Changes of the Plasma-protein Pattern in Cases of Hepatitis A date: 1988-09-01 words: 10541 flesch: 112 summary: Too f e w plasma samples w e r e a v a i l a b l e f r o m t h A r e p o r t e d h e r e showed t h a t t h e mean keywords: e n; e s; h e; n t; r e; t e; t h; t t cache: ujms-6834.pdf plain text: ujms-6834.txt item: #344 of 550 id: ujms-6861 author: Gislason, Thorarinn ; Sandhagen, Bo ; Daskalopouloul, Efi title: Ear Oximetry during Progressive Hypoxia date: 1988-09-01 words: 4736 flesch: 105 summary: x i m e t e r ( i o n m e t e r (Radiometer, Copenhagen, Denmark). keywords: e e; e n; e s; n t; r e; r t; t e cache: ujms-6861.pdf plain text: ujms-6861.txt item: #345 of 550 id: ujms-6864 author: Knibestöl, Martin ; Hägg, Erik ; Liliequist, Bengt title: Discrepances between CT and EEG Findings after Acute Cerebrovascular Disease date: 1988-09-01 words: 2645 flesch: 53 summary: An approximate characterization of the 5 grades of EEG abnormality is as follows: Grade 0 = Normal EEG Grade 1 = Slight abnormality - typically a few episodes of short duration, mainly theta-rhythms, 64 restricted to one lobe Grade 2 = Moderate abnormality - theta-delta activity covering about one half hemisphere, appearing continuously or as frequent episodes of moderate to long duration Grade 3 = Severe abnormality - continuous mainly delta activity covering a whole hemisphere, or frequent bilateral delta episodes occupying nearly 50% of the recordering Grade 4 = Very severe abnormality - continuous delta activity over both hemispheres RESULTS The results of the study are summarized in Table 1, where the principal clinical features (state of consciousness and hemisymptoms) as well as CT and EEG findings are presented. Ottonello, G.A., Regesta, G. & Tanganelli, P.: Correlation between computerized tomography and EEG findings in acute cerebrovascular disorders. keywords: eeg; findings; patients cache: ujms-6864.pdf plain text: ujms-6864.txt item: #346 of 550 id: ujms-6874 author: Ryde, Märta ; Gustavsson, Sven title: Effect of Olsalazine Sodium on Migrating Motor Complexes in the Upper Small Bowel of Human Volunteers date: 1987-09-01 words: 3010 flesch: 69 summary: Recording equipment: Small bowel manometry was used to study the effect of ADS on the MMCs in the upper small bowel. (14) that there are no similar distinct activities in the small bowel beside the migrating complexes, which makes us confident that all registrations were MMC complexes though the migration pattern was only identified in four of our subjects. keywords: ads; asa; dose; mmc; study; subjects cache: ujms-6874.pdf plain text: ujms-6874.txt item: #347 of 550 id: ujms-6875 author: Vahlquist, Anders ; Stenström, Eva ; Törmä, Hans title: Vitamin A and β-Carotene Concentrations at Different Depths of the Epidermis: A Preliminary Study in the Cow Snout date: 1987-09-01 words: 1932 flesch: 52 summary: Upsala J Med Sci 92: 253-257, 1987 Vitamin A and PCarotene Concentrations at Different Depths of the Epidermis: A Preliminary Study in the Cow Snout Anders Vahlquist, Eva Stenstrom and Hans Torma Department of Dermatology, Uppsala Uniuersity, Uppsala, Sweden ABSTRACT Vitamin A (retinol) is an anti-keratinizing agent essential for normal epithelial differentiation. In order to examine the epidermal distribution of vitamin A and provitamin A (i3-carotene), we took advantage of the extraordinarily thick snout epidermis of the cow which can be cut horizontally into at least 6 layers, representing keratinocytes at different stages of maturation. keywords: carotene; epidermis; retinol; samples; snout; vitamin cache: ujms-6875.pdf plain text: ujms-6875.txt item: #348 of 550 id: ujms-6878 author: Magnusson, Anders title: Object Size Determination at Computed Tomography date: 1987-09-01 words: 3758 flesch: 78 summary: When measured on an image of the object, reconstructed with a standard algorithm and a zoom factor of 6 at different WC settings (from 0 to 2300 H U ) and at a constant W W ( 4 0 0 HU), the diameter varied from 26 to 2 0 mm. When the high-density object was viewed with a large WW, so that the entire attenuation difference between the object and background was covered by W W , the border of the object against the background became diffuse and it was difficult to define any exact measurement points for the diameter in the image (Fig. 5 ) . keywords: t t cache: ujms-6878.pdf plain text: ujms-6878.txt item: #349 of 550 id: ujms-6879 author: Sylvén, Christer ; Hesser, Ulf ; Östby, Terje ; Broomé, UIrika ; Zackrisson, Lars title: Relations between Clinical Signs of Right and Left Cardiac Decompensation and Radiological Signs Thereof date: 1987-09-01 words: 1954 flesch: 60 summary: Right heart failure was best diagnosed with clinical parameters such as pitting oedema, filling of the jugu- lar vein, and liver enlargement. In fact Henriksson et a1 reported that the width of the major right hepatic vein was a reliable indica- tion of right heart failure. keywords: filling; heart; patients; right; vein cache: ujms-6879.pdf plain text: ujms-6879.txt item: #350 of 550 id: ujms-6885 author: Rask, Lars ; Anundi, Helena ; Fohlman, Jan ; Peterson, Per A. title: The Complete Amino Acid Sequence of Human Serum Retinol-binding Protein date: 1987-09-01 words: 12220 flesch: 72 summary: The materials subjected to amino acid sequence determination contained A) intact, reduced and alkylated RBP; 120 nmoles. 6 shows that amino acid sequence determinations of peptides SB (Table 7) and AC1 IV 1 (Table 9) provided the sequence Arg-Asn-Leu. keywords: acid; acid sequence; ala; amino; amino acid; arg; asp; asx; cnbr; fig; fragment; gly; human; leu; lys; peptides; phe; protein; rbp; retinol; sequence; ser; table; thr; val cache: ujms-6885.pdf plain text: ujms-6885.txt item: #351 of 550 id: ujms-6886 author: Benson, Lars ; Ljunghall, Sverker ; Groth, Torgny ; Falk, Hans ; Hvarfner, Andreas ; Rastad, Jonas ; Wide, Leif ; Åkerström, Göran title: Optimal Discrimination of Mild Hyperparathyroidism with Total Serum Calcium, Ionized Calcium and Parathyroid Hormone Measurements date: 1987-09-01 words: 33527 flesch: 112 summary: R A T 0 RY MET H OD S Blood specimens w e r e c A l l specimens w e r e assay- e d in d u p l keywords: e c; e e; e l; e n; e r; h e; n t; o n; r o; r t; s e; t e; t h; t o; t s; t t cache: ujms-6886.pdf plain text: ujms-6886.txt item: #352 of 550 id: ujms-6887 author: Sandler, Stellan ; Nilsson, Bo ; Andersson, Arne title: Cryopreservation of Mouse Pancreatic Islets: Effects of Human Serum on Islet Survival date: 1987-09-01 words: 8009 flesch: 96 summary: e t e D i a b e t e s 34:1113-1119, 1 9 8 5 . keywords: e n; e t; h e; l e; n t; r e; s e; t h cache: ujms-6887.pdf plain text: ujms-6887.txt item: #353 of 550 id: ujms-6888 author: Koskinen, Lars-Owe D. title: The Influence of Bilateral Electrical Preganglionic Sympathetic Stimulation on Intra- and Extracranial Blood Flow date: 1987-09-01 words: 4857 flesch: 86 summary: The e f f e c t s o f f e c t persisted throughout t h e s keywords: c t; e c cache: ujms-6888.pdf plain text: ujms-6888.txt item: #354 of 550 id: ujms-6889 author: Gislason, Thorarinn ; Taube, Adam title: Prevalence of Sleep Apnea Syndrome—Estimation by Two Stage Sampling date: 1987-09-01 words: 2893 flesch: 68 summary: This would mean that 197 Table 2 - Notations concerning population and sample POPULATION SAMPLE INDIVIDUALS OF SAS INDIVIDUALS OF SAS STRATUM NUMBER OF PREVALENCE NUMBER OF PROPORTION NL pL The parameter P is then estimated by No. of SAS cases in sample - psRS - No. of individuals in sample The estimate psRS of P has the standard error (SE) 1 if the population is large . keywords: population; risk; sas; sleep cache: ujms-6889.pdf plain text: ujms-6889.txt item: #355 of 550 id: ujms-6890 author: Hartvig, Per ; Gustafsson, Lars L. ; Bergström, Kjell ; Moström, Ulf ; Pontén, Urban ; Lindberg, Bo ; Lundqvist, Hans title: Positron Emission Tomography: An Animal Model of Spinal Distribution of Drugs after Intrathecal Administration date: 1987-09-01 words: 5910 flesch: 98 summary: i f f e r e n t v e r t e b r a e l e v e l s : L7: 50 mm; L1: 75 mm; T8: 170 mm; C7: 270 mm. o r e d keywords: e c; e e; e s; l e; n e; n t; r e; s t; t e; t h cache: ujms-6890.pdf plain text: ujms-6890.txt item: #356 of 550 id: ujms-6892 author: Wangenheim, M. ; Borg, G. ; HoIzmann, P. title: A Psychophysical Study of Work-Related Stress Using Observer Ratings date: 1987-03-01 words: 17806 flesch: 116 summary: i l e t h e r e was c l o s e r a g r e e m e n t o o v e r e s t keywords: e e; e n; e s; r e; t e cache: ujms-6892.pdf plain text: ujms-6892.txt item: #357 of 550 id: ujms-6893 author: Odlind, Bo ; Beermann, Björn ; Lindström, Björn ; Eriksson, Örjan title: Some Effects of Metolazone on Electrolyte Transport date: 1987-03-01 words: 21015 flesch: 113 summary: e t e r m I n t e r e s t keywords: c t; e c; e e; e l; e n; e s; e t; n t; o n; r e; r t; t o; t s cache: ujms-6893.pdf plain text: ujms-6893.txt item: #358 of 550 id: ujms-6894 author: Lyrenäs, Sven ; Nyberg, Fred ; Willdeck-Lund, Gunilla ; Lindström, Leif ; Lindberg, Bo ; Terenius, Lars title: Endorphin Activity in Cerebrospinal Fluid Prior to Elective Cesarean Section and in Early Puerperium date: 1987-03-01 words: 2942 flesch: 67 summary: o t r o p p o t r o keywords: csf; opioid; women cache: ujms-6894.pdf plain text: ujms-6894.txt item: #359 of 550 id: ujms-6895 author: Arner, Peter ; Engfeldt, Peter ; Skarfors, Einar ; Lithell, Hans ; Bolinder, Jan title: Insulin Receptor Binding and Metabolic Effects of Insulin in Human Subcutaneous Adipose Tissue in Untreated Non-insulin Dependent Diabetes Mellitus date: 1987-03-01 words: 8313 flesch: 95 summary: i f f e r also f r o m those published by Kolterman and co-workers who observed decreased adipocyte insulin binding i n untreated non-insulin dependent diabetics i f f e r between diabetics and non-diabetics. keywords: c t; e c; e l; e n; n t; r e; t e; t h; t r cache: ujms-6895.pdf plain text: ujms-6895.txt item: #360 of 550 id: ujms-6896 author: Lundberg, P. O. ; Muhr, C. ; Bergström, K. ; Bergström, M. ; Deuschl, H. ; Enoksson, P. ; Hagelquist, E. ; Thuomas, K.-A. ; Wide, L. title: Transsphenoidal Therapeutic Puncture of a Cystic Pituitary Adenoma date: 1987-03-01 words: 1353 flesch: 58 summary: Cysts within pituitary tumours may be recognized on CT. Enoksson, E. Hagelquist, K.-A. Thuomas and L. Wide Departments of Neurology, Diagnostic Radiology, Oto-Rhino-Laryngoiogy, Ophthalmology, Pathology and Clinicul Chemistry, University Hospital, Uppsala, Sweden ABSTRACT Transsphenoidal diagnostic puncture of skull base tumours has been a routine procedure in Uppsala for a decade. keywords: bromocriptine; needle; puncture; treatment; tumour cache: ujms-6896.pdf plain text: ujms-6896.txt item: #361 of 550 id: ujms-6897 author: Osman, E. M. ; Abboud, O. I. ; Danielson, B. G. title: Chronic Renal Failure in Khartoum, Sudan date: 1987-03-01 words: 6662 flesch: 111 summary: and i n t e r p r e t a t i n d remediable causes b e f o r e o u r p a t keywords: e n; n t; r e; t s cache: ujms-6897.pdf plain text: ujms-6897.txt item: #362 of 550 id: ujms-6899 author: Högstorp, H. ; Carlin, G. title: Two Forms of α2-antiplasmin: Post-traumatic Changes in the Rat date: 1987-03-01 words: 1501 flesch: 66 summary: Total AP was measured on the same plate, using pure Sepharose 4B in the inter- mediary agarose gel to equate any loss of antigen due to unspecific ad- sorption. All results are expressed in per cent of total AP found in pooled normal rat plasma. - Statistical analysis: Differences between groups were tested by Wilcoxon's rank sum test. keywords: plasma; plasminogen; rat cache: ujms-6899.pdf plain text: ujms-6899.txt item: #363 of 550 id: ujms-6900 author: Petersson, Birger title: The Effect of Cysteamine on the Somatostatin Content of Guinea-pig Islets date: 1987-03-01 words: 1190 flesch: 62 summary: Cysteamine was also incubated in vitro with isolated pancreatic islets from untreated guinea-pigs. In addition, cysteamine is known to decrease the somatostatin content of pancreatic islets in vitro (4, 5 ) . keywords: cysteamine; guinea; islets; somatostatin cache: ujms-6900.pdf plain text: ujms-6900.txt item: #364 of 550 id: ujms-6901 author: Cervén, Erik title: Validity of Hill's Equation in an Artificial Actomyosin Streaming System date: 1987-03-01 words: 14886 flesch: 116 summary: f m o v e m e n t on t h e TV s c r e e n . T h e e x p e r i m e n t a l c o n s t a n t s were d e t e keywords: e n; e t; n t cache: ujms-6901.pdf plain text: ujms-6901.txt item: #365 of 550 id: ujms-6904 author: Appelgren, Lars-Erik title: The Technique of Whole Body Autoradiography—Some Examples of Applications date: 1986-09-01 words: 7188 flesch: 113 summary: a i n tissue may be o f i n t e r e s t . a l ' l a b e l l i n g of i n t e r e s t keywords: e n; n t; t e cache: ujms-6904.pdf plain text: ujms-6904.txt item: #366 of 550 id: ujms-6905 author: Hammarström, Lars title: Autoradiography and Histochemistry of Mineralized Tissues by Means of the Ullberg Freeze-sectioning Technique date: 1986-09-01 words: 1325 flesch: 56 summary: The affinity of the tetracyclines to the mineralized tissues in combination with their property to be fluorescent in ultraviolet light, have made them useful tools for mor- phological studies on mineralized tissues and the whole-body sections have also been used for fluorescence microscopy. One of the advantages with the method is that all tissues may be analyz- ed without any preselection of tissues to be studied and it has lead to many unexpected results. keywords: activity; body; teeth; tissues cache: ujms-6905.pdf plain text: ujms-6905.txt item: #367 of 550 id: ujms-6908 author: d'Argy, Roland title: Image Analysis in Whole-body Autoradiography (WBA) date: 1986-09-01 words: 8391 flesch: 114 summary: i o n ) of i n t e r e s t . n s of i n t e r e s t in t h keywords: e n; e s; r e; t e cache: ujms-6908.pdf plain text: ujms-6908.txt item: #368 of 550 id: ujms-6910 author: Bergman, Kerstin title: Application of Whole-body Autoradiography to Distribution Studies of Volatile Substances date: 1986-09-01 words: 1185 flesch: 47 summary: A L AUTORADIOGRAPHY: Registration of non-volatile metabolites. Upsala J Med Sci 91: 269-272, 1986 Application of Whole-body Autoradiography to Distribution Studies of Volatile Substances Kerstin Bergman Toxicology Laboratory, National Food Administration, Box 622, S-75126 Uppsala, Sweden INTRODUCTION Exposure to volatile substances of toxicological significance takes place most frequently in occupational settings (e.g. organic solvents, plastics monomers), but volatile substances may be encountered also in e.g. clinical practice (anesthetic agents) or as constituents of tobacco smoke or food. keywords: autoradiography; body; studies; temperature cache: ujms-6910.pdf plain text: ujms-6910.txt item: #369 of 550 id: ujms-6940 author: Sörbo, Bo title: Analytical Quality date: 1986-09-01 words: 1498 flesch: 57 summary: There are optimists who claim that it is desirable and possible to perform bedside clinical chemis- try with the same precision and accuracy as conventional clinical chemistry in the laboratory but this is not a realistic attitude. However, returning back to precision and accuracy raises the question: Whatcan we demand of bedside clinical chemistry in these respects? keywords: bedside; chemistry; laboratory; quality; results cache: ujms-6940.pdf plain text: ujms-6940.txt item: #370 of 550 id: ujms-6941 author: Groth, Torgny title: Analytical Quality, Test Quality and Quality Costs date: 1986-09-01 words: 1556 flesch: 53 summary: Effects of the prevalence of e r r o r s on the performance of control procedures. For instance, i f analytical disturbances occur very seldom or never at all, or if the magnitude is negligible compared to allowable analytical e r r o r s , we do not actually need a quality control system. keywords: analytical; quality cache: ujms-6941.pdf plain text: ujms-6941.txt item: #371 of 550 id: ujms-6942 author: and Carl-Henric de Verdier, Compiled by Kristoffer Hellsing title: Round Table Discussion: The discussion was chaired by Carl-Henric de Verdier date: 1986-09-01 words: 1569 flesch: 63 summary: During the last years no case has been brought up to the Board about lia- bility within the area of clinical chemistry. One way of arguing within the group has been to state that we already have a pro- fession: clinical chemistry. keywords: care; chemistry; laboratory cache: ujms-6942.pdf plain text: ujms-6942.txt item: #372 of 550 id: ujms-6943 author: Berg, Bertel ; Tryding, Nils title: Clinical Chemistry in Primary Health Care: Relationship between hospital laboratories and general practice Questionnaire answers from 33 directors of clinical chemistry laboratories date: 1986-09-01 words: 284 flesch: 51 summary: Who has the formal and o r practical responsibility for clinical chemistry in primary health care within the region (for choice of methods, laboratory equipment, quality control, instrument service)? Special systems for sample transport from primary health care to hospital laboratories are established in 27 regions. keywords: regions cache: ujms-6943.pdf plain text: ujms-6943.txt item: #373 of 550 id: ujms-6944 author: von Schenck, Henning title: Paper Spotted Blood Glucose for Quality Control of Reflectance Meters date: 1986-09-01 words: 343 flesch: 58 summary: Methods: Capillary blood (- 50 p) was applied on filter paper. Upsala J Med Sci 91: 217, 1986 Paper Spotted Blood Glucose for Quality Control of Reflectance Meters Henning von Schenck Department of Clinical Chemistry, Linkoping University, Linkoping, Sweden The usefulness of blood glucose results obtained with various teststrips and reflectance mters rely mainly on the quality of the strip and the skills of the analyst. keywords: paper cache: ujms-6944.pdf plain text: ujms-6944.txt item: #374 of 550 id: ujms-6945 author: Falkensson, Marianne ; von Schenck, Henning title: Improved Reliability of Hemoglobin Assay with HemoCue for Satellite and Physicians Office Testing date: 1986-09-01 words: 278 flesch: 40 summary: This equipment is expected to deliver mre precise results because sample dilution is unnecessary and turbidity errors eliminated by read- ings at two wavelengths in a microcuvet. Upsala J Med Sci 91: 218, 1986 Improved Reliability of Hemoglobin Assay with HemoCue for Satellite and Physicians Office Testing Marianne Falkensson and Henning von Schenck Department of Clinical Chemistry, Linkoping University, Linkoping, Sweden Introduction: Filter photometry of cyanomethernoglobin at one wavelength fol- lowing dilution of capillary blood with Drabkins solution according to the rec- mndations of the International Comnittee of Standardization in Hematology (ICSH) is flawed by imprecision related to high sample dilution and by possible errors due to sample turbidity. keywords: hemocue cache: ujms-6945.pdf plain text: ujms-6945.txt item: #375 of 550 id: ujms-6946 author: Malm, Märta-Lisa ; von Schenck, Henning title: Education of Untrained Hospital Staff for Decentralizing of Reflectometric Blood Glucose Assay date: 1986-09-01 words: 338 flesch: 56 summary: External control remains imperative for meaningful decentralizing of blood glucose. First, glucose control solutions were used to determine the numberof outliers off the assigned values. keywords: blood; glucose cache: ujms-6946.pdf plain text: ujms-6946.txt item: #376 of 550 id: ujms-6948 author: Hellsing, Kristoffer ; Bernet, Catarina ; Lindbäck, Annika title: Experiences from a Laboratory Evaluation of a Solid Phase Analytical System date: 1986-09-01 words: 351 flesch: 61 summary: The second incubation time (after blood has been wiped off, varied 10-330s) is not critical. The decrease was, however, of the same size even using the reference method (Glucose analyser). keywords: time cache: ujms-6948.pdf plain text: ujms-6948.txt item: #377 of 550 id: ujms-6950 author: Berg, Bertel ; Olsson, Bengt ; Tryding, Nils title: New Seralyzer Compared to Routine Techniques in Clinical Chemistry date: 1986-09-01 words: 616 flesch: 69 summary: x + 3 0 r=0.994 223 Ne w Se ra ly ze r (S L ) co mp ar ed t o ro ut in e te ch ni qu es ( RT ) in c li ni ca l ch em is tr y Co mp on en t N Ro ut in e te ch ni qu e Co nc en tr at io n Y= a+ bX cv cv cv (A T) X= RT Be tw ee n- me th od Wi th in -m et ho d Qu al it y co nt - Ho sp it al l ab or at or y Y= Se ra ly ze r RT /S er al yz er RT tr ol p ro gr am fo r we st er n Sw ed en S- K+ S- Th eo ph yl li ne S- Cr ea ti ni ne 5- AS AT S- Bi li ru bi n S- CK B- He mo gl ob in S- Ch ol es te ro l 14 0 Upsala J Med Sci 91: 223-224, 1986 New Seralyzer Compared to Routine Techniques in Clinical Chemistry Bertel Berg, Bengt Olsson and Nils Tryding Department of Clinicaf Chemistry, Central Hospital, Kristianstad, Sweden New Seralyzer (AMES) is a reflectometer designed mainly for serum and blood analyses with solid-phase chemistry (reagent strips). keywords: seralyzer cache: ujms-6950.pdf plain text: ujms-6950.txt item: #378 of 550 id: ujms-6951 author: Kallner, Anders ; Jagenburg, Rudolf ; Berg, Bertel ; Hellsing, Kristoffer title: Working Group for the Rational Use of Urinary Test Strips date: 1986-09-01 words: 918 flesch: 59 summary: Such an app- roach is particularly important since many laboratories are faced with a demand to compare different reagent sets: It would be an advantage also if manufacturers would describe their products in these terms. Several reagent sets (chemicals and/or instruments) are in the process of being tested in accordance with this protocol. keywords: evaluation; reference; sample cache: ujms-6951.pdf plain text: ujms-6951.txt item: #379 of 550 id: ujms-6954 author: Cervén, Erik ; Ronquist, Gunnar title: Determination of Sialic Acid Residues in Transferrin by Oxidative-Reductive Immunoassay date: 1986-03-01 words: 10160 flesch: 111 summary: f e r r e d t e t e r o g e n e keywords: e l; e n; n s; n t; r e; t e; t r cache: ujms-6954.pdf plain text: ujms-6954.txt item: #380 of 550 id: ujms-6955 author: Styrud, Johan ; Dahlström, Elisabeth ; Eriksson, Ulf J. title: Induction of Skeletal Malformations in the Offspring of Rats Fed a Zinc Deficient Diet date: 1986-03-01 words: 6702 flesch: 97 summary: e t e r m They w e r e m a t e d overnight with male r a t s from t h e s a m e colony and conception w a s confirmed by examin- a t keywords: c e; e n; e s; e t; h e; n t; r e; t h; t r; t s; t t cache: ujms-6955.pdf plain text: ujms-6955.txt item: #381 of 550 id: ujms-6957 author: Wegener, Thomas ; Wallin, Rolf ; Saldeen, Tom title: Effect of N-Acetylcysteine on Fibrin Deposition in the Rat Lung due to Intravascular Coagulation date: 1986-03-01 words: 2201 flesch: 61 summary: In addition, after administration of NAC less fibrin was found in precapillary arterioles by a semiquantitative method , suggesting that NAC may decrease the formation of fibrin or increase its elimination from the lungs. The findings of Sim et a1 ( 1 1 ) that a relatively high concentration of NAC showed no fibrinolytic activity when added to fresh human fibrin plates supports our opinion that NAC does not excert its effect by increasing fibrin elimination. keywords: fibrin; fibrinogen; lung; nac; pulmonary; thrombin cache: ujms-6957.pdf plain text: ujms-6957.txt item: #382 of 550 id: ujms-6959 author: Wangenheim, M. ; Carlsöö, S. ; Nordgren, B. ; Linroth, K. title: Perception of Efforts in Working Postures date: 1986-03-01 words: 12328 flesch: 113 summary: i o u s l y t h e r e f t h e n e x t , t h e r e was c o n s t a n t v a r keywords: e s; n t; r e; r t; s t; t e; t h; t t cache: ujms-6959.pdf plain text: ujms-6959.txt item: #383 of 550 id: ujms-6960 author: Westman-Naeser, Sighild ; Grimelius, Lars ; Johansson, Henry ; Malmaeus, Jan title: Fine Needle Biopsy and Scintigram in the Preoperative Diagnosis of Thyroid Lesions date: 1986-03-01 words: 7885 flesch: 105 summary: I n 2 cases t h e r e was a f a l s e - p I n another 46 cases c o r r e s p o keywords: e l; e n; l l; n t; t h cache: ujms-6960.pdf plain text: ujms-6960.txt item: #384 of 550 id: ujms-6962 author: Wålinder, Olov ; Bergström, Ingmar ; Boethius, Göran ; Ugander, Lars title: Studies of Drug-treated Diabetes in the County of Jämtland, Sweden, Based on Prescription of Insulin and Oral Antidiabetic Drugs date: 1986-03-01 words: 5055 flesch: 89 summary: d y c o r r e s p o a r s t h e c o r r e s p o n keywords: r e; t e cache: ujms-6962.pdf plain text: ujms-6962.txt item: #385 of 550 id: ujms-6975 author: Andréen, Thomas ; Åberg, Torkel ; Fritjofsson, Åke title: Surgery of Renal Cancer with Extensive Caval Invasion: Suggestion for a new approach date: 1985-06-01 words: 6982 flesch: 109 summary: i n o m a - c u r r e n t s u r i n g P e r o p e r a t keywords: e l; e n; h e; n t; r e; r t; t e; t h cache: ujms-6975.pdf plain text: ujms-6975.txt item: #386 of 550 id: ujms-6977 author: Claesson, Kerstin ; Frödin, Lars ; Lörelius, Lars-Erik title: Ureteral Reflux and Ileal Conduit Pressure Following Diversion with a Reflux-preventing Technique date: 1985-06-01 words: 4984 flesch: 106 summary: t h e r e was c l i h r e e ( 4 7;) R e n a l f u n c keywords: e n; e s; e t; n t; r e cache: ujms-6977.pdf plain text: ujms-6977.txt item: #387 of 550 id: ujms-6978 author: Larson, Anders ; Fritjofsson, Åke title: Intravesical Ethoglucid (EpodylR) for Treatment of Noninvasive Bladder Cancer (Stage Ta) date: 1985-06-01 words: 6307 flesch: 112 summary: f them t h e r e was r e c u r r e n e t e r m keywords: e n; e t; n t; r e cache: ujms-6978.pdf plain text: ujms-6978.txt item: #388 of 550 id: ujms-6980 author: Stegmayr, Bernd ; Busch, Christer ; Fritjofsson, Åke ; Ronquist, Gunnar title: Biochemical and Morphologic Studies of the Prostate Gland in Men Subjected to Radical Cystectomy date: 1985-06-01 words: 3628 flesch: 93 summary: b o r d e r was o b s e r v e d between l o b e s i n e c r e t keywords: n t; t e cache: ujms-6980.pdf plain text: ujms-6980.txt item: #389 of 550 id: ujms-6981 author: Frödin, Lars ; Backman, Ulla title: Renal Transplantation in Uppsala date: 1985-06-01 words: 4850 flesch: 95 summary: i o n was p e r f o r m e d by P r o f e s s o r L a r s Thorkn, head o f t h e s u r g o g e t h e r w keywords: e n; n t; r e; t h cache: ujms-6981.pdf plain text: ujms-6981.txt item: #390 of 550 id: ujms-6982 author: Wahlberg, Jan ; Tufveson, Gunnar ; Frödin, Lars title: Urologic Complications in 159 Consecutive Renal Transplantations date: 1985-06-01 words: 5786 flesch: 104 summary: Case r e p o r t . i s p o s s i b l e t o p e r f o r m a u r e t e r o p e l v o s t o keywords: c t; e n; e t; n s; n t; o n; r e cache: ujms-6982.pdf plain text: ujms-6982.txt item: #391 of 550 id: ujms-6983 author: Wahlberg, Jan ; Backman, Ulla ; Frödin, Lars ; Stenkvist, Björn ; Tufveson, Gunnar title: Fine-needle Biopsies of Renal Transplants in Clinical Rejection Monitoring date: 1985-06-01 words: 6020 flesch: 109 summary: i e n t s is t h e r e f o r e o i e s u s u a l l y were p e r f o r m e d a t r e keywords: e c; e n; n t; r e; t e cache: ujms-6983.pdf plain text: ujms-6983.txt item: #392 of 550 id: ujms-6985 author: Person, A. Erik G. ; Boberg, Ulf title: Arterial Hypertension—A Disease of the Juxtaglomerular Apparatus? date: 1985-06-01 words: 6112 flesch: 98 summary: i n t e r e s t t h e r e was an a c keywords: e n; e s; h e; l e; n t; r e; r t; t e; t h cache: ujms-6985.pdf plain text: ujms-6985.txt item: #393 of 550 id: ujms-7022 author: Weiner, Erik ; Johansson, Ines ; Helmius, Gisela ; Odlind, Viveca title: Sexual and Contraceptive Experience among Teenagers in Uppsala date: 1984-06-01 words: 2214 flesch: 77 summary: A questionnaire was offered t o 181 sixteen-year-old boys (n=88) and girls (n=93) in different schools in the city of Uppsala. i r s t intercourse among girls and boys (1, 2 , 3 ) . keywords: boys; girls; intercourse cache: ujms-7022.pdf plain text: ujms-7022.txt item: #394 of 550 id: ujms-7055 author: Dedorson, S . ; Fritjofsson, Å. ; Norlen, B. J. ; Ronquist, G. title: Perspectives on Serum Acid Phosphatase in Prostatic Disease: An evaluation of two methods date: 1983-06-01 words: 4192 flesch: 83 summary: Between t h e t w o methods, t h e r e f o r e , no d i n g s were r e p o r t e d keywords: e t cache: ujms-7055.pdf plain text: ujms-7055.txt item: #395 of 550 id: ujms-7056 author: Boman, Kurt ; Möllerberg, Hans ; Ögren, Jan-Erik title: What do Patients Know about their Digitalis? A comparison between two different areas in Sweden date: 1983-06-01 words: 11247 flesch: 113 summary: T h e r e were 678 f e m a l e s and 505 males. T h e r e were 1 0 0 p a t keywords: e n; e s; n t; r e; t e; t s; t t cache: ujms-7056.pdf plain text: ujms-7056.txt item: #396 of 550 id: ujms-7057 author: Nilsson, B. Ove ; Grönvik, K.-O. ; Svalander, P. C. title: Experiments with Immunization of Mice with Blastocysts by an Intrasplenic Route date: 1983-06-01 words: 1184 flesch: 67 summary: Raising antiserum hgsinst blastocyst antigens is laborious, since a con- ventional immunization requires thousands of blastocysts ( 1 , 4 , 6 ) . Upsala J Med Sci 88: 151-153, 1983 Experiments with Immunization of Mice with Blastocysts by an Intrasplenic Route B . keywords: blastocysts; gold cache: ujms-7057.pdf plain text: ujms-7057.txt item: #397 of 550 id: ujms-7058 author: Lööf, Lars ; Nyberg, Anders title: Bile Salt Sulphation in Man: Liver bile salt sulphotransferase activity in patients with primary biliary cirrhosis date: 1983-03-01 words: 3233 flesch: 69 summary: The present data indicates that chronic chole- stasis, as evidenced in patients with primary biliary cirrhosis, does not lead to increased levels of liver bile salt sulphotransferase. No correlation was found between bile salt sulphotransferase activity and serum concentration o f bilirubin, total bile salt and alkaline phosphatases or to the intravenous 3 P T a b le 1 . keywords: activity; bile; cholestasis; cirrhosis; liver; patients; salt; sulphation; sulphotransferase cache: ujms-7058.pdf plain text: ujms-7058.txt item: #398 of 550 id: ujms-7059 author: Ahlsten, Gunnar ; Ewald, Uwe ; Tuvemo, Torsten title: Cord Blood Platelet Aggregation; Quality Control by a Two-sample Technique date: 1983-03-01 words: 9592 flesch: 111 summary: T h e i n t e r e s t T h e p l a t e l e t c o u n t of t h e P R P w a s d e t e keywords: e e; e n; e s; h e; l e; n t; r e; t e cache: ujms-7059.pdf plain text: ujms-7059.txt item: #399 of 550 id: ujms-7060 author: Eriksson, Ulf ; Ewald, Uwe ; Tuvemo, Torsten title: Increased Platelet Volume in Manifest Diabetic Rats date: 1983-03-01 words: 10391 flesch: 113 summary: i a b e t e s i n t Within 20 m i n u t e s of blood sampling, t h e p l a t e l e t n u m b e r w a s d e t e keywords: e e; e n; e s; l e; n t; r e; t e; t s cache: ujms-7060.pdf plain text: ujms-7060.txt item: #400 of 550 id: ujms-7062 author: Lewan, Lillemor ; Amnéus, Herman ; Forsberg, Ola ; Lundberg, Kerstin title: Intraarterial and Intraportal in vivo Catheterization of the Regenerating Rat Liver: Effects upon body and liver weights and DNA synthesis date: 1983-03-01 words: 10639 flesch: 113 summary: e t e r was f e t e r m keywords: e c; e l; e n; e r; e s; e t; n t; r t cache: ujms-7062.pdf plain text: ujms-7062.txt item: #401 of 550 id: ujms-7063 author: Lewan, Lillemor ; Forsberg, Ola ; Amnéus, Herman ; Lundberg, Kerstin ; Larsson, Börje title: Irradiation Effects upon Ischemic Regenerating Rat Liver Cells date: 1983-03-01 words: 8915 flesch: 113 summary: e t e r and t e t e r s i n j e c keywords: e n; e r; e s; n t; r r; r t; t e cache: ujms-7063.pdf plain text: ujms-7063.txt item: #402 of 550 id: ujms-7065 author: Åberg, Hans ; Lithell, Hans ; Hedstrand, Hans title: On Cerebrovascular Deaths in Middle-aged Men during a 7–10-year Follow-up date: 1983-03-01 words: 584 flesch: 68 summary: The ratio between deaths from SAH and other CVD was 3.5:l among the participants. The occurrence o f SAH should not be influenced to any great extent by an improved antihypertensive treatment which is considered to be the most likely explanation of the reduction of other CVD. keywords: men; sah cache: ujms-7065.pdf plain text: ujms-7065.txt item: #403 of 550 id: ujms-7066 author: Anderson, Bertil W. ; Gustafsson, Göran title: Standard Computer Programs in Statistical Analysis of Survival in Childhood Lymphoblastic Leukemia date: 1982-09-01 words: 3224 flesch: 74 summary: Treatment results (time variables in moths) a) Duration of first remission TCCR = Time in CCR, i.e. length of time from achieved remission to death during remission 0 ~ - to first relapse 0 ~ ' to close date. Frequency tables and cross tables analyse the material with re- gard to the distribution of different variables, e.g. age, sex, risk group, location of relapse, etc. keywords: ccr; children; table; therapy; time cache: ujms-7066.pdf plain text: ujms-7066.txt item: #404 of 550 id: ujms-7067 author: Adami, H. O. ; Axelsson, O. ; Carlström, K. ; Vegelius, J. ; Åkerström, G. title: Serum Levels of Cortisol, Dehydroepiandrosterone, Dehydroepiandrosterone Sulphate, Estrone and Prolactin after Surgical Trauma in Postmenopausal Women date: 1982-09-01 words: 4740 flesch: 75 summary: The presence of a preoperative s t r e s s a s an explanation is not supported by any other hormonal changes. Anterior pituitary function during surgical s t r e s s and convalescence. keywords: day; dha; serum cache: ujms-7067.pdf plain text: ujms-7067.txt item: #405 of 550 id: ujms-7068 author: Selking, Ö. ; Borch, K. ; Johansson, H. ; Ljunghall, S. ; Wide, L. title: Evaluation of Parathyroid Function in Patients with Hypergastrinaemia and Pernicious Anaemia date: 1982-09-01 words: 7531 flesch: 106 summary: a r a m e t e r s and t h e r e was no i o u s anaemia t h e r e was no p a t t e keywords: e n; n t; r e; t r cache: ujms-7068.pdf plain text: ujms-7068.txt item: #406 of 550 id: ujms-7069 author: Ericsson, Martin ; Johansson, Kurt ; Nordgren, Bengt ; Nordesjö, Lars-Olof ; Borges, Octavia title: Evaluation of a Dynamometer for Measurement of Isometric and Isokinetic Torques date: 1984-03-01 words: 6526 flesch: 109 summary: t h e r e i s t h e r e f o r e con- cluded keywords: h e; n t; r e; t h cache: ujms-7069.pdf plain text: ujms-7069.txt item: #407 of 550 id: ujms-7070 author: Hultman, Jan ; Forsberg, Jan Ola ; Hansson, Hans Erik ; Ronquist, Gunnar title: A Paracorporeal Rat Heart Model for Ischemic and Reperfusion Studies date: 1982-09-01 words: 4076 flesch: 79 summary: : Signifi- cance of enzyme release from ischemic isolated rat heart. Neely, J.R., Liebermeister, H., Battersby, E.J. & Morgan, H.E.: Effect of pressure development on oxygen consumption by isolated rat heart. keywords: r e; r t; t e cache: ujms-7070.pdf plain text: ujms-7070.txt item: #408 of 550 id: ujms-7071 author: Edlund, Bror ; Heldin, Carl Henrik ; Engström, Lorentz title: Effect of Chemical Modification of a Histidine and a Lysine Residue of Pea Seed Nucleoside Diphosphate Kinase date: 1982-09-01 words: 3466 flesch: 87 summary: Thus t h e r e seems t o be a INTRODUCTION E a r l The present investigation was therefore focused on the possibility that there might exist, in addition to the reactive histidine residue, a lysine residue, essential for enzyme activity, in the active site of pea seed NDP kinase. keywords: t h cache: ujms-7071.pdf plain text: ujms-7071.txt item: #409 of 550 id: ujms-7072 author: Edlund, Bror title: Effects of Chemical Modification of Lysine, Tyrosine and Tryptophan Residues in Pea Seed Nucleoside Diphosphate Kinase and Inhibition of the Enzyme with Antibodies date: 1982-09-01 words: 3274 flesch: 87 summary: f pea seed NDP k j n a s e (51, and t h e r e i n c e t h e r e m i keywords: e s; r e; t e cache: ujms-7072.pdf plain text: ujms-7072.txt item: #410 of 550 id: ujms-7073 author: Bergh, Torbjörn ; Nillius, Sven Johan ; Lundberg, Per Olof ; Moström, Ulf ; Enoksson, Paul ; Öhman, Lena ; Wide, Leif title: Rapid Regression of Pituitary Tumours during Bromocriptine Treatment of Women with Hyperprolactinaemia date: 1982-09-01 words: 2645 flesch: 63 summary: Here we report on results of primary bromocriptine treatment of four hyperprolactinaemic women who had large pituitary tumours with suprasellar extension. Repegt CT-scan after 2 weeks of bromocriptine treatment showed marked tumour regression but a small suprasellar portion still remained. keywords: bromocriptine; prolactin; suprasellar; treatment; tumour; women cache: ujms-7073.pdf plain text: ujms-7073.txt item: #411 of 550 id: ujms-7074 author: Hjelm, Magnus ; Arturson, Gösta title: The Amount of Adenine Nucleotides and Glycolytic Intermediates in Erythrocytes, Liver and Muscle Tissue Correlated with the Body Weight (Age) in Wistar Rats date: 1982-06-01 words: 9700 flesch: 111 summary: i d e r e r , G.: o r r e l a t keywords: c e; e l; e n; e s; n t; r e; r t; s t; t e; t h; t t cache: ujms-7074.pdf plain text: ujms-7074.txt item: #412 of 550 id: ujms-7075 author: Ewald, U. ; Gustafsson, I.-B. ; Tuverno, T. ; Vessby, B. title: Fatty Acid Composition of Serum Lipids in Diabetic Children and their Matched Healthy Controls date: 1982-06-01 words: 9418 flesch: 109 summary: e s w e r e d e t e o r r e l a t keywords: c e; e e; e n; e r; e t; n t; s e; t h; t r; t t cache: ujms-7075.pdf plain text: ujms-7075.txt item: #413 of 550 id: ujms-7076 author: Waern, A. Urban ; Lidell, C. ; Hellsing, K. title: Alcohol Intake, Serum β2-microglobulin and Ventricular Extrasystoles: Factors related to death in five-year follow up of middle-aged men date: 1982-06-01 words: 4259 flesch: 98 summary: I n t h e r e m a i n i n g 7 s u b j e c t s however, t h e r e were s i g n s o i g n a n t tumours and o t h e r causes r e s p e c keywords: r e cache: ujms-7076.pdf plain text: ujms-7076.txt item: #414 of 550 id: ujms-7077 author: Gustavsson, Sven ; Lundqvist, Gudmar title: Release of Insulin and Pancreatic Somatostatin in Response to Increased Circulating Growth Hormone (GH) Levels date: 1982-06-01 words: 5991 flesch: 101 summary: i n s e c r e t i n s e c r e t keywords: e e; e n; e t; l e; n s; n t; r e; s e; t s cache: ujms-7077.pdf plain text: ujms-7077.txt item: #415 of 550 id: ujms-7078 author: Johansson, Henry ; Wilander, Erik title: A Clincal Study of 30 Gastric Carcinoids date: 1982-06-01 words: 6798 flesch: 106 summary: G a s t r o e n t e r o G a s t r o e n t e r o keywords: e n; n t; r e; s t; t r cache: ujms-7078.pdf plain text: ujms-7078.txt item: #416 of 550 id: ujms-7079 author: Gamstorp, I. ; Sedin, G. title: Neonatal Convulsions Treated with Continuous, Intravenous Infusion of Diazepam date: 1982-06-01 words: 2854 flesch: 73 summary: In an investigation of infants with neonatal convulsions due to perinatal asphyxia, 8 infants - 2 girls and 6 boys - born at term in 1 9 7 4 - 7 6 were subjected to a special study concerning the effects of diazepam therapy. Continuous infusion of diazepam in infants with severe recurrent convulsions. keywords: diazepam cache: ujms-7079.pdf plain text: ujms-7079.txt item: #417 of 550 id: ujms-7080 author: Sohtell, Morgan ; Karlmark, Bertil title: Thermodynamical Aspects on the Determination of Bicarbonate in Urine date: 1982-06-01 words: 7080 flesch: 98 summary: r t h e r discussed by S i c s t r e keywords: e n; n t; r e; t e cache: ujms-7080.pdf plain text: ujms-7080.txt item: #418 of 550 id: ujms-7081 author: Holm, Sten ; Selstam, Gunnar title: Oxygen Tension Alterations in the Intervertebral Disc as a Response to Changes in the Arterial Blood date: 1982-06-01 words: 3565 flesch: 62 summary: For the disc we find that the longer the distance to the endplate or the greater the change in arterial oxygen tension, the longer the equilibrium time. The first increase of arterial oxygen tension always caused a greater in- crease in intradiscal oxygen tension than the later alterations I1 and 111. keywords: blood; changes; disc; endplate; oxygen; response; tension; time cache: ujms-7081.pdf plain text: ujms-7081.txt item: #419 of 550 id: ujms-7082 author: Almgren, B. ; Hemmingsson, A. title: Peripheral Embolization of Separated Angiographic Catheter date: 1982-06-01 words: 2700 flesch: 111 summary: i d e n c e o f 0.0008 p e r c e n t has been r e p o r t e d ( 3 ) , b u t a l s o a h e t e r , i.d. 1.58 mm, 0.d. keywords: e t cache: ujms-7082.pdf plain text: ujms-7082.txt item: #420 of 550 id: ujms-7085 author: Nylander, Eva ; Areskog, Nils-Holger title: New Aspects on Training Bradycardia date: 1982-03-01 words: 9780 flesch: 112 summary: e r e t h e s e a n i - mals t h e r e w a s keywords: e s; e t; n e; n t; r e; t h; t r; t s; t t cache: ujms-7085.pdf plain text: ujms-7085.txt item: #421 of 550 id: ujms-7149 author: LANNERGÅRD, ANDERS ; ROSENSTRÖM, FREDRIK ; NORMANN, ERIK ; LARSSON, ANDERS title: Serum pentraxin 3 concentrations in neonates date: 2014-01-17 words: 1379 flesch: 47 summary: However, regarding serum PTX3 concentrations in infants with infection we propose a prospective study on neonatal sepsis with well-defined established criteria. The cause of the prema- turity may also involve inflammatory reactions which will further increase the variability in PTX3 values in samples from prematurely born babies. keywords: newborns; ptx3; serum; term; uppsala cache: ujms-7149.pdf plain text: ujms-7149.txt item: #422 of 550 id: ujms-7163 author: Terakawa, Susumu title: Excitability of Squid Axon Membrane in the Absence of Ion-concentration Gradient across the Membrane date: 1980-09-01 words: 1843 flesch: 60 summary: Very similar responses in membrane potential described above could be observed with the use of manganese salts in the place of the cobalt salt. When a barium chloride solution was used, rise and fall of membrane potential repeated at -- - . . keywords: chloride; current; fig; membrane; responses cache: ujms-7163.pdf plain text: ujms-7163.txt item: #423 of 550 id: ujms-7169 author: Franck, Ulrich F. title: The Teorell Membrane Oscillator—a Complete Nerve Model date: 1980-09-01 words: 13700 flesch: 110 summary: e r e a t e t e r m keywords: c t; e e; e l; e n; e s; n t; r e; s t; t e; t t cache: ujms-7169.pdf plain text: ujms-7169.txt item: #424 of 550 id: ujms-7176 author: Taube, Adam title: Significance, Importance and Equality—Three Basic Concepts in the Analysis of a Difference date: 1980-06-01 words: 1865 flesch: 72 summary: For investigating whether equality is plausible, confidence intervals are more use- ful than non significant results from tests of significance. However, when we consider data set VI, we find a very narrow confidence interval, indicating that even as small values of the difference D as, say 1.5%, would be in contradiction with the data. keywords: data; difference cache: ujms-7176.pdf plain text: ujms-7176.txt item: #425 of 550 id: ujms-7192 author: Hallmans, Göran ; Lithner, Folke title: Early Changes in Zinc and Copper Metabolism in Rats with Alloxan Diabetes of Short Duration after Local Traumatization with Heat date: 1980-03-01 words: 2364 flesch: 55 summary: The changes of the copper concentrations in the liver were similar to those of zinc, however, they were not significant except in traumatized diabetic animals compared with controls (Fig. 4 ) . Serum copper concentrations were lower both in traumatized and nontraumatized diabetic animals compared with controls. keywords: animals; copper; serum; traumatization; traumatized; zinc cache: ujms-7192.pdf plain text: ujms-7192.txt item: #426 of 550 id: ujms-7199 author: Boberg, Jonas ; Boberg, Merike ; Gross, Richard ; Turner, John D. ; Augustin, Jan ; Brown, W. Virgil title: Hepatic Triglyceride and Lipoprotein Lipase Activities of Post-heparin Plasma in Normals and Hypertriglyceridemics date: 1979-09-01 words: 4849 flesch: 79 summary: Lipase activity was expressed as umoles fatty acids released per ml of post-heparin plasma per hour of incubation. Male patients with hypertriglyceridaemia had similar activities of H-TGL but significantly lower values for LPL activities than the control males. keywords: activities; lpl cache: ujms-7199.pdf plain text: ujms-7199.txt item: #427 of 550 id: ujms-7200 author: Adami, Hans-Olov ; Hansen, Jörgen ; Rimsten, Åke ; Wide, Leif title: Thyroid Function in Breast Cancer Patients before and up to Two Years after Mastectomy date: 1979-09-01 words: 2859 flesch: 69 summary: These results contradict previously proposed hypotheses of a progressive de- crease in thyroid function after primary treatment and of a relation between the clinical course and the thyroid function in breast cancer patients. The hypothesis that breast cancer and thyroid function are related to each other has been discussed from different viewpoints ever since Beatson in 1896 (4) suggested thyroid as a treatment in advanced breast cancer. keywords: breast; cancer; function; patients; thyroid cache: ujms-7200.pdf plain text: ujms-7200.txt item: #428 of 550 id: ujms-7201 author: Terent, Andreas title: A Prospective Epidemiological Survey of Cerebrovascular Disease in a Swedish Community date: 1979-09-01 words: 5394 flesch: 83 summary: t stands for the number given to each consecutive five-year age group in which stroke cases were registered; the lowest age group in which stroke appeared being No. 1. i n r e t r o s p e c keywords: e n; e s; n t; stroke cache: ujms-7201.pdf plain text: ujms-7201.txt item: #429 of 550 id: ujms-7202 author: Johansson, H. ; Grimelius, L. ; Heitz, U. ; Lundqvist, G. ; Peterson, P. ; Portela-Gomes, G. ; Wilander, E. title: The Effects of Endogenous Hypergastrinemia and Hypogastrinemia on the Exocrine and Endocrine Rat Pancreas date: 1979-09-01 words: 3971 flesch: 73 summary: The relative number of exocrine cells was calculated by multiplying the corrected number of exocrine cells per unit volume by the exocrine pancreatic weight. The observed number of exocrine cell nuclei per unit volume was highest in the control group and lowest in group AR. keywords: e e; e t; l e; s e cache: ujms-7202.pdf plain text: ujms-7202.txt item: #430 of 550 id: ujms-7204 author: Adami, Hans-Olov ; Johansson, Elof D. B. ; Vegelius, Jan ; Victor, Arne title: Serum Concentrations of Estrone, Androstenedione, Testosterone and Sex-hormone-binding Globulin in Postmenopausal Women with Breast Cancer and in Age-matched Controls date: 1979-09-01 words: 19214 flesch: 109 summary: i n t e r e s t . i n t e r e s t . keywords: c e; e e; e l; e n; e s; n s; n t; o n; r e; r o; s t; t e; t o; t r cache: ujms-7204.pdf plain text: ujms-7204.txt item: #431 of 550 id: ujms-7205 author: Gustafsson, Gunnar ; Johansson, Henry ; Molin, Björn ; Sundström, Christer ; Thelin, Anne-Marie title: Clinical and Surgical Staging of Hodgkin's Disease date: 1979-09-01 words: 2206 flesch: 57 summary: Conflicting data exist whether or not there is a definite risk of postsplenectomy infections in 279 individuals with Hodgkin‘s disease (2,6). This case of splenectomy undoubtly points to the risk but the possi- bilities of positive findings in the spleen strongly advocate splenectomy as a part in staging procedure of Hodgkin‘s disease. keywords: cases; disease; hodgkin; liver; patients; staging cache: ujms-7205.pdf plain text: ujms-7205.txt item: #432 of 550 id: ujms-7206 author: Bowald, S. ; Almgren, B. ; Eriksson, I. ; Jacobson, G. ; Lörelius, L.-E. title: Rupture of an Abdominal Aortic Aneurysm into the Vena Cava date: 1979-09-01 words: 1122 flesch: 67 summary: Beall, A.C., Cooley, D.A., Morris, G.C. & DeBakey, M.E.: Perforation of plication of abdominal aortic aneurysms. Unusual problems of abdominal aortic aneurysms. keywords: aneurysm; aortic; caval; fistula cache: ujms-7206.pdf plain text: ujms-7206.txt item: #433 of 550 id: ujms-7216 author: Backman, Christer ; Holm, Sonja ; Linderholm, Håkan title: Reaction to Cold of Patients with Coronary Insufficiency date: 1979-06-01 words: 7964 flesch: 112 summary: i n t e r e s t . n s i s t h e r e f o r e o f keywords: e n; e s; n t; r e; t e; t s; t t cache: ujms-7216.pdf plain text: ujms-7216.txt item: #434 of 550 id: ujms-7217 author: Nordgren, Bengt ; Elmeskog, Alf ; Nilsson, Agne title: Method for Measurement of Maximal Isometric Muscle Strength with Special Reference to the Fingers date: 1979-06-01 words: 2114 flesch: 68 summary: The variation in repeated finger strength measurements on the same person (Table I) is greater on the ulnar than on the radial side, which may be an expression of the better muscular coordination on the thumb side. Measurement of finger strength: The muscle strength in the fingers varies between about 0.05 and 15 kp (i.e.wO.5 and 150 Newton), thus including comparatively very low strengths and percentually large range of variation. keywords: digit; finger; measurement; muscle; strength cache: ujms-7217.pdf plain text: ujms-7217.txt item: #435 of 550 id: ujms-7218 author: Nilsson, B. Ove ; Ljung, Leif title: Electron Probe Micro-X-ray Analyses of Electrolyte Composition of Fluid Microsamples by Use of a Sephadex Bead date: 1979-03-01 words: 694 flesch: 63 summary: In order to circumvent these problems, we have developed a new technique where we use Sephadex beads as carriers of the fluid to be analyzed. Grids prepared with Sephadex beads are carbon coated before the analyses. keywords: analyses; beads cache: ujms-7218.pdf plain text: ujms-7218.txt item: #436 of 550 id: ujms-7219 author: Östenson, Claes-Göran ; Naeslund, Grels ; Nilsson, B. Ove title: Differential Effect of Cupric Ions on the In Vitro Utilization of Glucose by Blastocysts and Pancreatic Islets date: 1979-03-01 words: 2551 flesch: 62 summary: i t , Biomedical C e n t r e , V p p s u l a , S\t,eden ABSTRACT To evaluate a possible interference of cupric ions on the trophoblast cell metabolism, glucose utilization was studied in mouse blastocysts delayed & utero and later activated by oestradiol for 18 h. Isolated pancreatic islets from guinea pigs were used for comparative purposes. To evaluate a possible interference by copper on the cell metabolism, glucose utilization was studied in isolated mouse blastocysts. keywords: blastocysts; cells; copper; glucose; ions; islets; mouse; utilization cache: ujms-7219.pdf plain text: ujms-7219.txt item: #437 of 550 id: ujms-7220 author: Naeslund, Grels title: The Effect of Glucose-, Arginine- and Leucine-deprivation on Mouse Blastocyst Outgrowth In Vitro date: 1979-03-01 words: 5000 flesch: 61 summary: After transfer of blastocysts growth arrested in vitro for 5 days to a complete medium including both glucose and the two amino acids, normal out- growths occurred within two or three days. The present experiments focus on the influence of this type of substance on blastocyst growth and viability. keywords: arginine; blastocysts; days; glucose; growth; implantation; leucine; medium; outgrowth; vitro cache: ujms-7220.pdf plain text: ujms-7220.txt item: #438 of 550 id: ujms-7221 author: Nillius, Sven Johan ; Wide, Leif title: Effects of Prolonged Luteinizing Hormone-releasing Hormone Therapy on Follicular Maturation, Ovulation and Corpus Luteum Function in Amenorrhoeic Women with Anorexia Nervosa date: 1979-03-01 words: 16339 flesch: 107 summary: r e e were l a b e l l e d a s a n o r e c t e r e was a normal r e s p o n s e t o LRH. keywords: e e; e n; e s; h e; l e; n t; o n; r e; s t; t e; t o; t r; t t cache: ujms-7221.pdf plain text: ujms-7221.txt item: #439 of 550 id: ujms-7222 author: Landelius, Johan ; Nordgren, Lars title: Evaluation of a Computer Programme for Interpretation of 12-lead Electrocardiograms date: 1979-03-01 words: 3719 flesch: 59 summary: Upsala J Med Sci 84: 3 7 4 6 , 1979 Evaluation of a Computer Programme for Interpretation of 12-lead Electrocardiograms Johan Landelius and Lars Nordgren F r o m the Department o j Clinical Physialogy, University Hospital, Uppsula, S w e d e n ABSTRACT A 12-lead electrocardiogram (ECG) interpretation programme (Cardionics, Brussels) was tested for computer diagnosis of ECG. In 11 tracings out of 12 the reader and computer diagnoses agreed, the sensitivity of the computer diagnosis being 92 Z and its specificity 9 9 . keywords: cases; computer; criteria; diagnosis; ecg; ecgs; programme; readers cache: ujms-7222.pdf plain text: ujms-7222.txt item: #440 of 550 id: ujms-7224 author: Hallmans, Göran ; Lithner, Folke ; Hägg, Erik title: Local Traumatization with Heat—Cutaneous Reactions and Early Effects on Serum Zinc Concentration in Rats with Alloxan Diabetes of Very Short Duration date: 1979-03-01 words: 1953 flesch: 64 summary: There was no difference between diabetic animals and controls with regard to the increase of water content of traumatized skin or to the water content of non-traumatized skin. Concerning the early reaction, there was no difference between diabetic animals and controls. keywords: animals; controls; diabetic; traumatization; zinc cache: ujms-7224.pdf plain text: ujms-7224.txt item: #441 of 550 id: ujms-7225 author: Norberg, Bo ; Norberg, Astrid ; Parkhede, Ulf ; Gippert, Hans ; Åkerman, Måns title: The Effect of Short-term High-dose Treatment with Methenamine Hippurate of Urinary Infection in Geriatric Patients with Indwelling Catheters: I. The preparation and morphology of a quantified urine sediment date: 1979-03-01 words: 7179 flesch: 108 summary: i n t e r e s t t e r keywords: e c; e l; e n; e s; n t; r e; t e cache: ujms-7225.pdf plain text: ujms-7225.txt item: #442 of 550 id: ujms-7226 author: Norberg, Astrid ; Norberg, Bo ; Parkhede, Ulf ; Gippert, Hans ; Ekman, Rolf title: The Effect of Short-term High-dose Treatment with Methenamine Hippurate of Urinary Infection in Geriatric Patients with Indwelling Catheters: II. Evaluation by means of a quantified urine sediment date: 1979-03-01 words: 11061 flesch: 114 summary: e t e r ( 2 , 6 , 7 , 8 ) . e t e r : 4 , 1 5 ) , t h e b keywords: e l; e n; n t; r e; t e; t r; t t cache: ujms-7226.pdf plain text: ujms-7226.txt item: #443 of 550 id: ujms-7227 author: Ejeskär, Arvid ; Holm, Sten title: Oxygen Tension Measurements in the Intervertebral Disc: A methodological and experimental study date: 1979-03-01 words: 4186 flesch: 66 summary: Effect of low oxygen tensions on glucose-metabolizing enzymes in cultured articular chondrocytes. Goteborg, Su,eden ABSTRACT A polarographic membrane-covered electrode has been used for measurements of oxygen tension in the intervertebral disc. keywords: disc; electrode; fig; kpa; measurements; membrane; oxygen; saline; tension; time cache: ujms-7227.pdf plain text: ujms-7227.txt item: #444 of 550 id: ujms-7228 author: Erikson, Uno ; Ericsson, Martin ; Persson, Rune title: On the Relation between Peripheral Atherosclerosis and Serum Lipoproteins date: 1979-03-01 words: 3218 flesch: 63 summary: INTRODUCTION An increased incidence of hyperlipidaemia and hyperlipoproteinaemia in patients with peripheral arterial disease (PVD) has been noted by several authors (1,4,5,15,16,17,22,24). There appear to be no reports in the literature on the relation between angiographic changes in peripheral arteries and serum lipoprotein levels. keywords: arterial; arteries; changes; cholesterol; lipoprotein; patients; serum cache: ujms-7228.pdf plain text: ujms-7228.txt item: #445 of 550 id: ujms-7229 author: TITANJI, VINCENT P. K. title: Separation of Rat-Liver Phosphoprotein Phosphatases Active on Phosphorylated Pyruvate Kinase (Type L) date: 1978-09-01 words: 3702 flesch: 58 summary: Titanji Table I. Purification of phospkoprotein phosphatases f r o m rat-liver cell-sap Phosphoprotamine and phosphopyruvate kinase phosphatase activities varied widely between 0.12-0.4 and 0.01- 0.03 pmol (3ZP)phosphate released per g wet weight of liver and min respectively (based on recoveries from cell-sap). In this particular experiment 14400 units of phosphoprotamine phosphatase and 1 200 units of phosphopyruvate kinase phosphatase were re- covered in the cell-sap from 60 g of liver. keywords: activity; fractions; kinase; liver; phosphatase; phosphoprotein; phosphopyruvate; pyruvate cache: ujms-7229.pdf plain text: ujms-7229.txt item: #446 of 550 id: ujms-7230 author: NÆSLUND, GRELS ; LUNDKVIST, ÖRJAN title: Effect of the Endocrine State of Blastocyst Donors on the Time Required for Initiation of Trophoblast Outgrowth date: 1978-09-01 words: 2687 flesch: 71 summary: RESULTS The frequency distributions for the moment of initi- ation of blastocyst outgrowth are summarized in Fig. The moment of initiation of blastocyst outgrowth was estimated by microscopic observations of the blastocyst cultures. keywords: blastocysts; day; delay; oestrogen; outgrowth; vitro cache: ujms-7230.pdf plain text: ujms-7230.txt item: #447 of 550 id: ujms-7231 author: HERBAI, GEORG ; WESTMAN-NAESER, SIGHILD ; CARLSSON, LARS ; NILSSON, KLAS title: Prolonged Serum Insulin Decreasing Effects of Two Synthetic Somatostatin Analogues Studied in vivo by a New Animal Method: Preliminary Communication date: 1978-09-01 words: 2555 flesch: 60 summary: Effects of somatostatin analogues on serum insulin 143 insulin values. MATERIAL AND METHODS Male 5-7 months old obese-hyperglycaemic mice, with high serum insulin values (150-250 ngiml), were selected, Unsalo J Mrd .5( i 83 142 G. Herbai et al. keywords: hormone; insulin; serum; somatostatin cache: ujms-7231.pdf plain text: ujms-7231.txt item: #448 of 550 id: ujms-7233 author: WAERN, URBAN title: Health and Disease at the Age of Sixty: Findings in a Health Survey of 60-year-old Men in Uppsala and a Comparison with Men 10 Years Younger date: 1978-09-01 words: 6295 flesch: 71 summary: The somewhat lower figure could be explained by the larger number of older men who were already under the care of another physician. Atrial fibrillation also showed a higher prevalence in the group of older men. keywords: age; blood; group; health; increase; index; men; number; population; serum; study; subjects; uppsala; year cache: ujms-7233.pdf plain text: ujms-7233.txt item: #449 of 550 id: ujms-7259 author: CERVÉN, ERIK title: The Plasma Membrane Consists of Two Polar–Nonpolar–Polar Leaflets: Interpretation of Some Data, Mainly from the Erythrocyte date: 1977-09-01 words: 10530 flesch: 58 summary: Organization of membrane proteins. It is the aim of this work t o examine data that are difficult to reconcile with the fluid mosaic model for the structure of cell membranes (95) and that tend to support the concept that such membranes consist of two parallel polar-nonpo- lar-polar leaflets. keywords: biochim; biological; biophys; cell; electron; erythrocyte; erythrocyte membrane; freeze; ghosts; inner; leaflet; lipid; membrane; model; outer; plasma; polar; proteins; structure; surface cache: ujms-7259.pdf plain text: ujms-7259.txt item: #450 of 550 id: ujms-7263 author: BERGQVIST, D. ; FALK, J. ; STÅHL, A. title: Tissue Reaction to Implantation of Collagen Film: An Experimental and Clinical Study date: 1977-09-01 words: 3058 flesch: 56 summary: Collagen film group: material from the implanted collagen film could be demonstrated in the centre of all five implantation sites by positive van Gieson staining, a basophil staining with haematoxylin- eosin, and a disorganized pattern of fibres not seen in normally occurring collagen. Collagen film group: remains of the implanted collagen film were still present in all 5 rabbits and adjacent to this foreign material there was cellular infiltration indicating ongoing phagocytosis. keywords: collagen; film; implantation; rabbits; reaction; tissue; weeks cache: ujms-7263.pdf plain text: ujms-7263.txt item: #451 of 550 id: ujms-7265 author: Team, The UJMS Editorial title: Symposium organized by the Swedish Nutrition Foundation and Uppsala University, Uppsala, June 20–22, 1977 date: 1977-09-01 words: 5856 flesch: 53 summary: It is in this respect of interest to note that already in 1964 a group of Swedish pediatricians worked out “Medi- cal standards for marketing of infant foods”. In a report from Egypt, malnourished mothers had lower yields than normal mothers. keywords: breast; child; children; countries; feeding; food; health; infant; milk; mother; nutritional; pregnancy; weight; women cache: ujms-7265.pdf plain text: ujms-7265.txt item: #452 of 550 id: ujms-7302 author: RONQUIST, GUNNAR ; ÅGREN, GUNNAR ; EKLUND, STEN ; WERNSTEDT, CHRISTER title: Cyclic 3′,5′-GMP Independent Protein Kinase at the Outer Surface of Intact Ehrlich Cells date: 1977-02-01 words: 3753 flesch: 59 summary: The commercial phosvitin preparation was free from protein kinase activi- ty. Protein kinase mediated phosphorylation of the rat liver plasma membrane. keywords: acceptor; cells; cyclic; ehrlich; gmp; kinase; membrane; phosphorylation; protein; surface cache: ujms-7302.pdf plain text: ujms-7302.txt item: #453 of 550 id: ujms-7304 author: FRITHZ, GÖRAN ; ERICSSON, PER ; RONQUIST, GUNNAR title: Adenylate Kinase Activity in Cerebrospinal Fluid in Connection with Transitory Ischaemic Attacks date: 1977-02-01 words: 2324 flesch: 68 summary: To our knowledge, no studies have so far been published concerning adenylate kinase activity in cerebrospinal fluid, neither under normal condi- tions nor in connection with TIA. Frithz et al. Table I. Adenylate kinase activity in CSF from I 1 patients with TZA analysed for adenylate kinase activity. keywords: activity; adenylate; cerebrospinal; fluid; kinase; spinal; tia cache: ujms-7304.pdf plain text: ujms-7304.txt item: #454 of 550 id: ujms-7305 author: WIDE, LEIF ; BIRGEGÅRD, GUNNAR title: A Solid Phase Radioimmunoassay Method for Ferritin in Serum using 125I-labelled Ferritin date: 1977-02-01 words: 3421 flesch: 67 summary: T h e average percentage of labelled ferritin bound to B w a s 10.1k1.5 (S.D.). DISCUSSION One prerequisite for achieving high sensitivity in a competitive inhibition radioimmunoassay technique for ferritin using labelled ferritin is the labelling of this protein to a sufficiently high specific activity. keywords: arb; assay; ferritin; iron; levels; mean; method; serum cache: ujms-7305.pdf plain text: ujms-7305.txt item: #455 of 550 id: ujms-7306 author: NILLIUS, SVEN JOHAN ; WIDE, LEIF title: Acute Effects of a New Stimulatory Luteinizing Hormone-releasing Hormone Analogue D-Ser(TBU)6-EA10-LRH on the Gonadotrophin and Gonadal Steroid Secretion in Women with Amenorrhoea date: 1977-02-01 words: 3805 flesch: 68 summary: A single subcutaneous injection of 10 p g of the analogue evoked a 20-fold increase of the L H level in blood and a 5-fold increase of the FSH Acute effects ofa LRH analogue in amenorrhoea 25 level with maxima at 4 and 6 h after the administra- tion respectively. Wide L H LRH -W LRH S.C. LH m iv 0 - 0 keywords: administration; analogue; fsh; hormone; level; lrh; women cache: ujms-7306.pdf plain text: ujms-7306.txt item: #456 of 550 id: ujms-7307 author: ÅBERG, HANS ; STRÖM, GUNNAR ; WERNER, IVAR title: On the Reproducibility of Exercise Tests in Patients with Atrial Fibrillation date: 1977-02-01 words: 2862 flesch: 73 summary: INTRODUCTION We have previously reported on exercise tests in patients with atrial fibrillation (2, 3). In another study we have investigated the influ- ence of different dose rates of digitalis on the heart rate and on the working capacity in patients with atrial fibrillation during exercise tests (3). keywords: exercise; fibrillation; heart; patients; tests cache: ujms-7307.pdf plain text: ujms-7307.txt item: #457 of 550 id: ujms-7309 author: BALDWA, V. S. ; BHANDARI, C. M. ; PANGARIA, A. ; GOYAL, R. K. title: Clinical Trial in Patients with Diabetes Mellitus of an Insulin-like Compound Obtained from Plant Source date: 1977-02-01 words: 1827 flesch: 63 summary: Medical College Hospital, Jaipur, India ABSTRACT Clinical study of an insulin-like compound obtained from vegetable source (vegetable insulin) was carried out on nine patients with diabetes mellitus. Subse- quently they were able to extract out the active principle in a pure protein from (vegetable insulin, v-insulin) which could be used as a hypoglycaemic agent i n human beings after biological standardiza- tion ( 5 ) . keywords: blood; diabetes; insulin; mellitus; patients; vegetable cache: ujms-7309.pdf plain text: ujms-7309.txt item: #458 of 550 id: ujms-7312 author: RENTZHOG, L. ; WIKSTRÖM, S. title: Corticosteroid Therapy in Regional Small Bowel Ischaemia: An Experimental Study in Rats date: 1977-02-01 words: 3497 flesch: 60 summary: Selkurt, E. E., Scibetta, M. P. & Cull, T. E.: Hemodynamies of intestinal circulation. Altura & Altura ( 1 ) claim that in these doses corticosteroids unspecifically inhibit the effect of vasoconstriction that may be released in intestinal ischaemia. keywords: animals; arc; circulation; dose; end; exchange; hydrocortisone; ischaemia; mes cache: ujms-7312.pdf plain text: ujms-7312.txt item: #459 of 550 id: ujms-7321 author: HEDSTRAND, HANS ; VESSBY, BENGT title: Detection and Characterization of Hyperlipoproteinaemia in Middle-aged Men date: 1976-09-01 words: 5236 flesch: 65 summary: I I A and IIB (p3 times ETC use) 210 (39%) 328 (61%) ETC size (n = 508) 37 F (SA) ASA: I-II (healthy or minor illness) versus III-V (very ill to moribund); ETC size: 37F versus 41F; Insertion method: with versus without laryngoscope; number of number of attempts: one attempt versus more than one attempt; Qualification: anaesthesiologist versus other physicians; Experience: Beginner (1–3) versus Experienced (>3); Duration of ETC in situ: <1 h, 1–2 h, >2 h; Block volume oropharyngeal cuff: recommended volume versus more than recommended (>85 mL for 37F, >100 mL for 41F); Block volume esophago-tracheal cuff: recommended volume versus more than recommended (>10 mL). keywords: airway; anaesthesia; combitube; complications; device; doi; etc; patients; study; tongue; tracheal; use; ventilation cache: ujms-9212.pdf plain text: ujms-9212.txt item: #545 of 550 id: ujms-9234 author: Modiri, Ali-Reza; Frithiof, Robert; Luther, Tomas; Frykholm, Peter title: The Aura-Gain laryngeal mask for airway management in neonatal inguinal hernia surgery. A feasibility study date: 2023-03-01 words: 1482 flesch: 52 summary: Ambu® AuraGain™ versus LMA Supreme™ Second Seal™: a randomised controlled trial comparing oropharyngeal leak pressures and gastric drain function- ality in spontaneously breathing patients. A feasibility study Ali-Reza Modiri, Robert Frithiof, Tomas Luther and Peter Frykholm Department of Surgical Sciences, Section of Anaesthesiology and Intensive Care Medicine, Uppsala University, Uppsala, Sweden Background The benefits of the laryngeal mask airway (LMA) for elective procedures requiring general anesthesia in children are well documented. keywords: anesthesia; events; infants; lma; study cache: ujms-9234.pdf plain text: ujms-9234.txt item: #546 of 550 id: ujms-9290 author: Gedeborg, Rolf; Holm, Lennart; Feltelius, Nils; Sundström, Anders; Eggers, Kai M.; Nurminen, Marja-Leena; Grünewald, Maria; Pihlström, Nicklas; Zethelius, Björn; Ljung, Rickard title: Validation of myocarditis diagnoses in the Swedish patient register for analyses of potential adverse reactions to COVID-19 vaccines date: 2023-05-11 words: 4524 flesch: 43 summary: As only a random selection of myocarditis cases unexposed to the COVID-19 vaccine was  validated, a random selection of unexposed myocarditis cases not validated was reclassified proportionate to the reclassification in the validated subset. UPSALA JOURNAL OF MEDICAL SCIENCES 2023, 128, e9290 http://dx.doi.org/10.48101/ujms.v128.9290 Validation of myocarditis diagnoses in the Swedish patient register for analyses of potential adverse reactions to COVID-19 vaccines Rolf Gedeborga,b, Lennart Holmc, Nils Felteliusc, Anders Sundströmd, Kai M Eggerse, Marja-Leena Nurminend, Maria Grünewaldf, Nicklas Pihlströmf, Björn Zetheliusc and Rickard Ljungc,g aDepartment of Efficacy and Safety 1, Division of Licensing, Medical Products Agency, Uppsala, Sweden; bDepartment of Surgical Sciences, Uppsala University, Sweden; cOffice of Use and Information, Division of Use and Information, Medical Products Agency, Uppsala, Sweden; dDepartment of Drug Safety, Division of Use and Information, Medical Products Agency, Uppsala, Sweden; eDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden; fStatistics group, Department of Efficacy and Safety 2, Division of Licensing, Medical Products Agency, Uppsala, Sweden; gInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden ABSTRACT Background: Coronavirus disease 2019 (COVID-19) mRNA vaccines are associated with an increased risk of myocarditis using hospital discharge diagnoses as an outcome. keywords: cases; collaboration; covid-19; diagnosis; level; myocarditis; patient; record; register; review; study; vaccine cache: ujms-9290.pdf plain text: ujms-9290.txt item: #547 of 550 id: ujms-9300 author: Davidson, Lee Ti; Schilling, Ulf Martin; Arnqvist, Hans J.; Nystrom, Fredrik H.; Chisalita, Simona I. title: Association of physiological stress markers at the emergency department to readmission and death within 90 days: a prospective observational study date: 2023-05-03 words: 6216 flesch: 54 summary: Conclusions In non-critical patients presenting with undifferentiated CP and/ or SOB in the ED, multimorbidity is the only baseline information of importance for predicting readmission and/or death within 90 days. Elevated plasma levels of MR-proADM, MR-proANP, and copeptin are physiological stress markers, indicating severe underlying disease, which is highly valuable for risk stratification and prognostic information for ED patients (15–18). keywords: copeptin; days; death; department; doi; emergency; multimorbidity; patients; proadm; proanp; readmission; risk; study; tnt cache: ujms-9300.pdf plain text: ujms-9300.txt item: #548 of 550 id: ujms-9340 author: Emami, Azita; Theorell, Töres; Kim, Hyejin; Berglund, Lars; Hallinder, Helena; Engström, Gabriella title: Assessing stress using repeated saliva concentration of steroid hormones in dementia care dyads: results from a controlled pilot care music intervention date: 2023-05-05 words: 5971 flesch: 56 summary: In this study we demonstrate that music intervention was associated with lower morning saliva cortisol concentrations for FCGs. Of those 72, 18 dyads declined to participate and the remaining 58 dyads (32 for intervention group and 26 for comparison group) consented to participate in this study. keywords: caregivers; collection; control; cortisol; dementia; dhea; group; intervention; morning; music; pwd; saliva; stress; study cache: ujms-9340.pdf plain text: ujms-9340.txt item: #549 of 550 id: ujms-9392 author: Hidman, Josefin; Larsson, Anders; Thulin, Måns; Karlsson, Torbjörn title: Increased plasma endostatin and GDF15 in indolent non-Hodgkin lymphoma date: 2023-05-09 words: 5079 flesch: 48 summary: However, studies of anti-angiogenic agents in NHL patients, have generally not shown favor- able outcomes. Therapies using anti-angiogenic agents in NHL patients have not shown the same favorable outcomes as seen in treatment of patients with solid tumors (6). keywords: angiogenesis; cancer; controls; disease; doi; endostatin; gdf15; indolent; levels; lymphoma; nhl; patients; plasma; symptomatic; uppsala cache: ujms-9392.pdf plain text: ujms-9392.txt item: #550 of 550 id: ujms-9473 author: Ekström, Mia-Maria; Tiblad, Eleonor; Norman, Mikael; Stephansson, Olof; Granfors, Michaela title: Maternal, pregnancy and neonatal outcomes in triplet pregnancies in Sweden – a nationwide cohort study date: 2023-07-17 words: 5731 flesch: 56 summary: UPSALA JOURNAL OF MEDICAL SCIENCES 2023, 128, e9473 http://dx.doi.org/10.48101/ujms.v128.9473 Maternal, pregnancy and neonatal outcomes in triplet pregnancies in Sweden – a nationwide cohort study Mia-Maria Ekströma, Eleonor Tiblada,b, Mikael Normanc, Olof Stephanssona,b and Michaela Granforsa,b aClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; bDivision of Obstetrics, Department of Women’s Health, Karolinska University Hospital, Stockholm, Sweden; cDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden ABSTRACT Background: Triplet pregnancies carry a high risk of pregnancy-related complications. The secondary aim was to compare outcomes in expectantly managed triplet pregnancies with triplet pregnancies where fetal reduction had been performed with the only indication to reduce the number of fetuses. keywords: birth; cohort; data; infants; neonatal; outcomes; pregnancies; pregnancy; reduced; reduction; sweden; triplet; weeks cache: ujms-9473.pdf plain text: ujms-9473.txt