Authors' reply: ‘Mean platelet volume could be a promising biomarker to monitor dietary compliance i Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=iups20 Upsala Journal of Medical Sciences ISSN: 0300-9734 (Print) 2000-1967 (Online) Journal homepage: https://www.tandfonline.com/loi/iups20 Authors' reply: ‘Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease' Tugrul Purnak, YAVUZ BEYAZIT, CUMALI EFE, ERSAN OZASLAN, OSMAN YUKSEL & EMIN ALTIPARMAK To cite this article: Tugrul Purnak, YAVUZ BEYAZIT, CUMALI EFE, ERSAN OZASLAN, OSMAN YUKSEL & EMIN ALTIPARMAK (2013) Authors' reply: ‘Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease', Upsala Journal of Medical Sciences, 118:3, 208-208, DOI: 10.3109/03009734.2013.806617 To link to this article: https://doi.org/10.3109/03009734.2013.806617 © Informa Healthcare Published online: 10 Jul 2013. Submit your article to this journal Article views: 311 View related articles Citing articles: 1 View citing articles https://www.tandfonline.com/action/journalInformation?journalCode=iups20 https://www.tandfonline.com/loi/iups20 https://www.tandfonline.com/action/showCitFormats?doi=10.3109/03009734.2013.806617 https://doi.org/10.3109/03009734.2013.806617 https://www.tandfonline.com/action/authorSubmission?journalCode=iups20&show=instructions https://www.tandfonline.com/action/authorSubmission?journalCode=iups20&show=instructions https://www.tandfonline.com/doi/mlt/10.3109/03009734.2013.806617 https://www.tandfonline.com/doi/mlt/10.3109/03009734.2013.806617 https://www.tandfonline.com/doi/citedby/10.3109/03009734.2013.806617#tabModule https://www.tandfonline.com/doi/citedby/10.3109/03009734.2013.806617#tabModule Upsala Journal of Medical Sciences. 2013; 118: 208–208 LETTER TO THE EDITOR Authors’ reply: ‘Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease’ TUGRUL PURNAK1, YAVUZ BEYAZIT1, CUMALI EFE3, ERSAN OZASLAN1, OSMAN YUKSEL4 & EMIN ALTIPARMAK4 1Ankara Numune Education and Research Hospital, Department of Gastroenterology, Ankara, Turkey, 2Ankara Yuksek Ihtisas Education and Training Hospital, Department of Gastroenterology, Ankara, Turkey, 3Hacettepe University Medical School, Department of Gastroenterology, Ankara, Turkey, and 4Ankara Diskapi Education and Research Hospital, Department of Gastroenterology, Ankara, Turkey We thank Dr Varol for his interest in our article (1). First of all, we agree with Dr Varol regarding the methodological concern of mean platelet volume (MPV) assessments (2). Blood samples must be stud- ied within 2 hours, as in our study, to avoid falsely elevated results. Also, when commenting MPV values in different studies, one must be cautious about the analyzer device. Different analyzer devices might produce different MPV results, and this fact should be taken into account before generalization of the results. Therefore, we tried to use the same analyzer device (Beckman Coulter analyzer) as in our previous studies (3,4). Secondly, Dr Varol mentions in great detail vari- ables which affect MPV. Currently, almost all diseases may influence MPV. Excluding MPV-related diseases is practically impossible, but to some extent, however, researchers might take appropriate measures to avoid fluctuations of MPV. Moreover, our main driving force behind this study was to find a useful marker for dietary compliance of celiac patients other than the change in MPV. Finally, we find Dr Varol’s hypothesis very intrigu- ing regarding a relationship between celiac disease and cardiovascular disease. Hitherto, with respect to cardiovascular mortality among celiac patients, studies have yielded conflicting results. However, in a recent study performed in a large group of patients, it was concluded that celiac patients have more favor- able cardiac profiles compared with controls (5). As a result of that, our current knowledge about celiac disease is evolving, and all clues including Dr Varol’s hypothesis will broaden our horizon. References 1. Purnak T, Efe C, Yuksel O, Beyazit Y, Ozaslan E, Altiparmak E. Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease. Ups J Med Sci. 2011;116:208–11. 2. Varol E. Comment on ‘Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease’. Ups J Med Sci. 2013;118:206–7. 3. Purnak T, Olmez S, Torun S, Efe C, Sayilir A, Ozaslan E, et al. Mean platelet volume is increased in chronic hepatitis C patients with advanced fibrosis. Clin Res Hepatol Gastroen- terol. 2013;37:41–6. 4. Beyazit Y, Sayilir A, Torun S, Suvak B, Yesil Y, Purnak T, et al. Mean platelet volume as an indicator of disease severity in patients with acute pancreatitis. Clin Res Hepatol Gastroen- terol. 2012;36:162–8. 5. Emilsson L, Carlsson R, Holmqvist M, James S, Ludvigsson JF. The characterisation and risk factors of ischaemic heart disease in patients with coeliac disease. Aliment Pharmacol Ther. 2013; 37:905–14. Correspondence: Tugrul Purnak, MD, Ankara Numune Education and Research Hospital, Department of Gastroenterology, Talatpasa Bulvari, Samanpazari 06100 Sihhiye, Ankara, Turkey. Fax: +90 312 3125026. E-mail: purnakt@yahoo.com (Received 13 May 2013; accepted 14 May 2013) ISSN 0300-9734 print/ISSN 2000-1967 online � 2013 Informa Healthcare DOI: 10.3109/03009734.2013.806617 http://informahealthcare.com/journal/ups www.ncbi.nlm.nih.gov/pubmed/21679011?dopt=Abstract www.ncbi.nlm.nih.gov/pubmed/21679011?dopt=Abstract www.ncbi.nlm.nih.gov/pubmed/22572524?dopt=Abstract www.ncbi.nlm.nih.gov/pubmed/22572524?dopt=Abstract www.ncbi.nlm.nih.gov/pubmed/22572524?dopt=Abstract www.ncbi.nlm.nih.gov/pubmed/22572524?dopt=Abstract www.ncbi.nlm.nih.gov/pubmed/22572524?dopt=Abstract www.ncbi.nlm.nih.gov/pubmed/22572524?dopt=Abstract www.ncbi.nlm.nih.gov/pubmed/22088974?dopt=Abstract www.ncbi.nlm.nih.gov/pubmed/22088974?dopt=Abstract www.ncbi.nlm.nih.gov/pubmed/23451861?dopt=Abstract www.ncbi.nlm.nih.gov/pubmed/23451861?dopt=Abstract mailto:purnakt@yahoo.com ss1 References