U J All Final for WEB.pdf 815Vol. 10 | No. 1 | Winter 2013 |U R O LO G Y J O U R N A L A Rare Paraneoplastic Dermatomyositis in Bladder Cancer with Fatal Outcome Ran Xu, Zhaohui Zhong, Hongyi Jiang, Lei Zhang, Xiaokun Zhao KEYWORDS: paraneoplastic syndromes, dermatomyositis, urinary bladder neoplasms INTRODUCTION - - pared to the general population. Only a small number of cases of dermatomyositis associated - CASE REPORT - 2 solid tumor on the Corresponding Author: Hongyi Jiang, MD Department of Urology, The Second Xiangya Hospital, Cen- tral South University, Changsha, Hunan, China Tel: +86 138 7480 3788 Fax: +86 073 185 294 082 E-mail: ddf20@sina.com Received January 2011 Accepted April 2011 The Second Xiangya Hospital, Central South University, Chang- sha, Hunan, China CASE REPORT 816 | - - munological tests, including anti-double-stranded DNA anti- - ent metastatic disease. rectum or pelvic lymphatics. Because of concern for healing impairment due to long-term corticosteroid administration, forming an intestinal neobladder. - DISCUSSION - - - - Case Report Association between dermatomyositis and bladder cancer in the English literature.£ Reference Age, y Gender Initial diagnosis Time interval Treatment Pathology Prognosis 1* 79 male BC 24 m TURBT + intravesical immunotherapy G1 BTCC death 2 60 male BC 2 w Chemotherapy G3T3N2 BTCC metastasis death 3 61 male BC 2 w Surgery + radiotherapy T2 BTCC metastasis death 4 68 male BC 13 m Surgery + radiotherapy G4 BTCC metastasis death 5* 62 male concurrent Radical cystectomy + ileal conduit + radiotherapy T3 BTCC metastasis death 6 64 male DM 12 m Surgery + chemotherapy G3T2N2 BTCC metastasis death 7* 75 male concurrent Surgery + radiotherapy G3T1b BTCC 8 63 male DM 2 m Surgery BTCC £BC indicates bladder cancer; DM, dermatomyositis; TURBT, transurethral resection of bladder tumor; BTCC, bladder transitional cell carcinoma; m, months; and w, weeks. *Symptoms of DM improved after treatment of bladder cancer. 817Vol. 10 | No. 1 | Winter 2013 |U R O LO G Y J O U R N A L Fatal Paraneoplastic Dermatomyositis in Bladder Cancer | Xu et al transitional cell carcinoma in all the subjects. Improvement of clinical symptoms of dermatomyositis after treatment of These observations suggest dermatomyositis as a paraneo- plastic syndrome. Malignancies may occur before, concur- - dermatomyositis, symptoms of bladder cancer are relatively latent. A thorough urologic evaluation should be undertak- - ported, and all of them had high-risk bladder cancer. This is that too much attention is paid to the dermatomyositis, dermatomyositis itself may be a marker of poor prognosis in malignancy. - - carcinoma, and indicates a poor prognosis. Third, a thorough urologic evaluation should be undertaken for dermatomy- for bladder cancer recurrence. CONFLICT OF INTEREST None declared. REFERENCES 1. Sabio JM, Vargas-Hitos JA, Jimenez-Alonso J. Paraneoplas- tic dermatomyositis associated with bladder cancer. Lupus. 2006;15:619-20. 2. Garcia-Donoso C, Sanchez-Munoz A, Lopez-Medrano F. Dermatomyositis and transitional cell carcinoma of the bladder: a rare paraneoplastic syndrome associated with tumor recurrence. Eur J Intern Med. 2003;14:397-8. 3. Robinson AJ, Alcock CJ. Dermatomyositis in association with transitional cell carcinoma of the bladder. Clin Oncol (R Coll Radiol). 2001;13:50-1. 4. Federman DG, Radonich M, Kirsner RS. Fatal bladder cancer and dermatomyositis. South Med J. 2000;93:492-3. 5. Talanin NY, Bushore D, Rasberry R, Rudolph T, Tuli M, Friedman-Musicante R. Dermatomyositis with the features of inclusion body myositis associated with carcinoma of the bladder. Br J Dermatol. 1999;141:926-30. 6. Rankin WR, Herman JR. Rapidly progressive transitional cell carcinoma associated with dermatomyositis. J Urol. 2002;167:639-40. 7. Mallon E, Osborne G, Dinneen M, Lane RJ, Glaser M, Bunker CB. Dermatomyositis in association with transitional cell carcinoma of the bladder. Clin Exp Dermatol. 1999;24:94-6. 8. Apaydin R, Gul U, Bahadir S, Siviloglu C, Ofluoglu I. Dermatomyositis without muscle weakness associated with transitional cell carcinoma of the bladder. J Eur Acad Dermatol Venereol. 2002;16:172-4.