1175ff.pdf 892 | Mohammad Reza Safa- rinejad, MD Clinical Center for Urologi- cal Disease Diagnosis and Private Clinic Specialized in Urological and Andrologi- cal Genetics, Tehran, Iran E-mail: info@safarinejad.com EDITORIAL COMMENT The authors have addressed an important issue in timely manner. The effect of cell phone radiation on human health is the matter of recent awareness and debate, as a result of the enormous increase in cell phone usage worldwide. Up to November 2011, there were about 6 billion subscriptions throughout the world.(1) Cell phones use electromagnetic radiation (EMR) in the microwave range. The WHO has classi- group 2B, may be carcinogenic. It means that there “could be some risk” of carcinogenicity; hence, further studies on the long-term, profound use of cell phones are warranted.(2) Several national radiation advisory authorities have suggested measures to decrease exposure to their citizens as a precautionary measure.(3) Many researchers have studied possible health effects of cell phone radiation. A recent evaluation (4) It denotes that the three lines of evidence, viz. animal, - likely to result in an increase in cancer in humans". Cell phones have also radiation absorption, thermal, non-thermal, cognitive, genotoxic, sleep and electroencephalography, behavioral, and blood–brain barrier effects, which have not been ad- dressed in the present study. Part of the radio waves emitted by a cell phone handset is absorbed by the human head. The radio waves emitted by a Global System for Mobile Communications (GSM) handset preserve a peak power of 2 watts. One well-documented effect of microwave radiation is dielectric heating, in which any dielectric material, such as living tissue, is heated by rotations of The communications protocols used by cell phones often give rise to low-frequency pulsing of the (5,6) Most studies have addressed the effects of cell phone usages on the head cancer. To my knowledge, there is no study addressing the effects of cellular telephone use on the kidney cancer. Therefore, the present animal study is welcome as a pilot study. In 2007, Hardell and colleagues, from Örebro University in Sweden, reviewed published epide- miological studies and concluded that:(7) A study entitled "Public health implications of wireless technologies" cites that Hardell and associ- before age 20 increased the risk of brain tumors by 5.2-fold, compared to 1.4-fold for all ages.(8) A review article by Hardell and colleagues found that current cell phones are not safe for long-term exposure.(9) Several national radiation advisory authorities, such as Austria,(3) France,(10) Germany,(11) and Swe- den,(12) have recommended measures to minimize exposure to their citizens, such as: Cellular and Molecular Urology 893Vol. 10 | No. 2 | Spring 2013 |U R O LO G Y J O U R N A L Effects of Cell Phone on Kidney | Koca et al The effects of the non-ionizing radiation emitted by cell phones depend on a number of factors besides the duration of transmission, eg, the type of cell phone and the distance from the cell phone tower. The authors examined only the controlled studies on human are needed to clarify whether the EMR from cell phones affects the kidney, and to determine the mode of action of such a possible damaging effect. REFERENCES 1. "Market Data Summary (Q2 2009)". GSM Association. http:// www.gsmworld.com/newsroom/market-data/ market_ data_summary.htm. Retrieved 2010-01-30. 2. "IARC classifies radiofrequency electromagnetic fields as possibly carcinogenic to humans". International Agency for Research on Cancer. 2011-05-31. Retrieved 2011-06-02. 3. "Information: Wie gefährlich sind Handystrahlen wirklich?" Marktgemeinde Pressbaum. Retrieved 2008-01-23. 4. "Conclusions on mobile phones and radio frequency fields". European Commission Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR). Retrieved 2008-12-08. 5. Foster KR, Repacholi MH. Biological effects of radiof- requency fields: does modulation matter? Radiat Res. 2004;162:219-25. 6. Glaser, Roland (December 2005). "Are thermoreceptors responsible for "non-thermal" effects of RF fields?" (PDF). Edition Wissenschaft (Bonn, Germany: Forschungsgemein- schaft Funk) (21). OCLC 179908725. Retrieved 2008-01-19. 7. Hardell L, Carlberg M, Soderqvist F, Mild KH, Morgan LL. Long-term use of cellular phones and brain tumours: increased risk associated with use for > or =10 years. Occup Environ Med. 2007;64:626-32. 8. Sage C, Carpenter DO. Public health implications of wire- less technologies. Pathophysiology. 2009;16:233-46. 9. Hardell L, Carlberg M, Hansson Mild K. Epidemiological evi- dence for an association between use of wireless phones and tumor diseases. Pathophysiology. 2009;16:113-22. 10. "Téléphones mobiles : santé et sécurité" (French). Le ministère de la santé, de la jeunesse et des sports. 2008-01- 02. Retrieved 2008-01-19. . 11. "Precaution regarding electromagnetic fields". Federal Office for Radiation Protection. 2007-12-07. Retrieved 2008-01-19. . 12. "Exponering". Swedish Radiation Protection Authority. February 2006. Retrieved 2008-01-19. REPLY BY AUTHOR There are many studies investigating the effect of EMR on human body.(1,2) Many of these studies research about cancer. However, long-term outcomes of these studies are unclear. In our study, we could not come up with any conclusion about cancer due to the lack of fol- low-up. However, there are a lot of non-cancer effects of EMR,(3) which we aimed to investigate in this study. The use of the mobile phone puts the head area at great- er risk.(2,4) This situation can also hide possible risks for other organs. In this study, we investigated the effects of REFERENCES 1. Leszczynski D, Joenvaara S, Reivinen J, Kuokka R. Non- thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: molecular mechanism for cancer- and blood-brain barrier- related effects. Differentiation. 2002;70:120-9. 2. Ono T, Saito Y, Komura J, et al. Absence of mutagenic effects of 2.45 GHz radiofrequency exposure in spleen, liver, brain, and testis of lacZ-transgenic mouse exposed in utero. Tohoku J Exp Med. 2004;202:93-103. 3. Nakamura H, Matsuzaki I, Hatta K, Nobukuni Y, Kambayashi Y, Ogino K. Nonthermal effects of mobile-phone frequency microwaves on uteroplacental functions in pregnant rats. Reprod Toxicol. 2003;17:321-6. 4. Finnie JW, Blumbergs PC, Cai Z, Manavis J, Kuchel TR. Effect of mobile telephony on blood-brain barrier permeability in the fetal mouse brain. Pathology. 2006;38:63-5.