LETTER

Re: The Effect of Aerobic Training on Serum Levels of Adiponectin, Hypothalamic-Pituitary-Gonadal 
Axis And Sperm Quality in Diabetic Rats

Nicola Zampieri

This is an intersting manuscript about the role of adiponectin and hormones and their relationship with fertility potential. Those working with infertility, have always to remember that abnormal semen analysis could be 
associated with many systemic diseases. 
Diabetes mellitus, obesity and hypogonadism are often associated with abnormal semen analysis; it is well known 
that after bariatric procedures there is an improvement in semen quality and also after hormones therapy in those 
cases of hypogonadisms. What is less known is about the recovery of spermatogenesis in diabetes mellitus patients 
but this study can explain how and when. In clinical practice all these diseases can be associated with each-other 
and for this reason all these patients should have weight control and should have a good sport activity. If bariatric 
surgery can reduces diabetes mellitus, hypertentyion and hypogonadism (abnormal hormonal axis – FSH,LH and 
TT), aerobic training can improve semen quality through the adiponectin action for all these patients.(1-2)
TT action is related to the adipose tissue, and testicular volume has a relationship with spermatogenesis and fertility 
potential. Probably in clinical practice these patients have lower testicular volume respect to controls(3). Sport activ-
ity can improve hormonal function, with lower adipose tissue percentage higher adiponectin levels and higher TT 
with improvement in semen quality. An interesting key point is to verify in humans if there is also in these patients 
a  correlation between spermatogenesis and testicular volume especially after weight control. 

REFERENCES
 1. Engin-Ustun Y, Yılmaz N, Akgun N, Aktulay A, Tuzluoğlu AD, Bakırarar B.Body Mass Index Effects 

Kruger's Criteria in Infertile Men. Int J Fertil Steril. 2018;11:258-62.
 2. Aly JM, Polotsky AJ.Paternal Diet and Obesity: Effects on Reproduction. Semin Reprod Med. 

2017;35:313-7.
 3.  Liu Y, Ding Z.Obesity, a serious etiologic factor for male subfertility in modern society.Reproduction. 

2017;154:R123-R131

Pediatric Surgical Unit
Woman and Child Hospital
Azienda Ospedaliera Universitaria Itegrata, Piazzale A.Stefani n.1, 37134 Verona,  Italy.
E-mail: dr.zampieri@libero.it

Urology Journal/Vol 17 No. 2/ March-April 2020/ pp. 215-215. [DOI: 10.22037/uj.v0i0.5265]