Letter to editor Dear editor With warm greetings Is the Plume of the Surgery on the Covid 19 Patient in the Pandemic Era (world fight) Definitely Safe? What Must to Do?!!!! With becoming the corona virus pandemic in Iran and the world it is important for the surgeons care of all the corona patients if he or she must be operated surgically. As it is a rule that the safety of the patients and all the workers of the operating room is one of the important responsibilities of the physician which we discuss for it in this letter. Inducing of the aerosol in the cauterization depends to the temperature as the temperature increases the formation of aerosol will be increased (1) this aerosol contains 95 % water and 5% particles (1) these particles contain blood and tissue also it may contain the corona virus which lives for three hours in the place. The Aerosol contains bacteria and virus which may be spread in the space and in the further place, the presence of the virus and bacteria in the aerosol have been confirmed which including HPV virus and AIDS virus and hepatitis B virus and mycobacterium tuberculosis (2) which may induce an infection of the surgeon and the staff of the operating room and also it may contaminate the garments of the staff of the operating room. The presence of the virus covid 19 in the urine of the patient with covid 19 virus-positive has been confirmed (3). The Surgical smoke contains much toxic gas, Specifically benzene and butadiene like in the smoke of the cigar rete and 10 and 17 times more than in the second- hand smoker (4). In TURP (trans urethra prostate resection) 16 kinds of the carcinogen gas and in TURBT (transurethral resection bladder tumor) 39 kinds of carcinogen gas have been detected and in a study laparoscopic nephrectomy was associated with 5 kinds of the carcinogen gas (5,6) but in the pandemic covid 19 virus the transmission of the virus by surgery as an aerosol cannot be excluded (7). The aerosol in the operating room must be considered a one of the important problems which must be defeated by the negative pressure and the suctioning. For the safety of surgeons and the staff of the theater room, especially for the caring in the operation of a patient suspicious to covid 19 defeating aerosol by precious negative pressure and suctioning looks justice until the presence of the definitive evidence about the absence of the covid 19 in the surgery smoke of the suspicious to co vid 19 will be provided (7). With best regards Afshar Zomorrodi , Professor of urology and kidney transplant , Head of organ transplantation and urology department, Tabriz university of medical science 1- Jonathan Pavlinec and Li-Ming Su ,Surgical Smoke in the Era of the COVID-19 PandemicdIs It Time to Reconsider Policies on Smoke Evacuation? THE JOURNAL OF UROLOGY® https://doi.org/10.1097/JU.0000000000001142 Vol. 204, 642-644, October 2020 Printed in U.S.A 2- Baki Ekci, Easy-to-use electrocautery smoke evacuation device for open surgery under the risk of the COVID-19 pandemic, Journal of International Medical Research,2020 ,48(8) 1–7 3- Ling Y, Xu SB, Lin YX et al: Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients. Chin Med J (Engl) 2020; 133: 1039 4- Liu Y, Song Y, Hu X et al: Awareness of surgical smoke hazards and enhancement of surgical smoke prevention among the gynecologists. J Cancer 2019; 10: 2788 5. Zhao C, Kim MK, Kim HJ et al: Comparative safety analysis of surgical smoke from transurethral resection of the bladder tumors and transurethral resection of the prostate. Urology 2013; 82: 744. 6. Choi SH, Kwon TG, Chung SK et al: Surgical smoke may be a biohazard to surgeons performing laparoscopic surgery. Surg Endosc 2014; 28: 2374 7-30. Pavan N, Crestani A, Abrate A, et al. Risk of virus contamination through surgical smoke during minimally invasive surgery: a systematic review of literature on a neglected issue revived in the COVID- 19 pandemic era [published online ahead of print, 2020 Jun 5]. Eur Urol Focus 2020: S2405-4569: 30156-5. DOI: 10.1016/j.euf.2020.05.021