Hrev_master Veins and Lymphatics 2013; volume 2:e1 [Veins and Lymphatics 2013; 2:e1] [page 1] Stiffness of compression devices Giovanni Mosti Angiology Department, Clinica MD Barbantini, Lucca, Italy This issue of Veins and Lymphatics collects papers coming from the International Compression Club (ICC) Meeting on Stiffness of Compression Devices, which took place in Vienna on May 2012. Several studies have demonstrated that the stiffness of compression products plays a major role for their hemodynamic efficacy. According to the European Committee for Standardization (CEN), stiffness is defined as the pressure increase produced by medical compression hosiery (MCH) per 1 cm of increase in leg circumference.1 In other words stiffness could be defined as the ability of the bandage/stockings to oppose the muscle expansion during contraction. Measurements of stiffness are performed in textile laboratories using different extensome- ters. However, up to now pressure ranges are declared only for compression stockings; no pressure ranges can be declared for bandages as the exerted pressure depends on the stretch applied to the bandages, number of layers and leg configuration. Information concerning stiffness is not given either for elastic stock- ings or for bandages. In vivo experiments have offered useful sur- rogate data. The leg circumference increases when moving from the supine to the standing position and during muscle activities.2-4 To assess stiffness according to CEN defini- tion, it would be necessary to measure the increase of compression pressure and of leg circumference simultaneously, requiring a pressure measurement device and a strain gauge plethysmograph. In order to simplify the stiffness calculation it has been proposed to assume that the increase of leg-circumfer- ence, moving from lying to standing position, is always 1 cm. In this case the so-called static stiffness index (SSI) could simply be calculat- ed by subtracting the supine from the standing pressure.5 A comparison between the two measuring systems of stiffness (the first including the measurement of the leg circum- ference increase and the second just calculat- ing SSI) was performed showing the same sensitivity and specificity in distinguishing between elastic and inelastic systems.2 The conclusion of this comparison clarified that SSI is an effective method to calculate stiff- ness and that more complex measurements do not give more information. Nevertheless the assessment of stiffness in vivo, as recommended in a previous consensus meeting of the ICC,6 came under some criti- cism. Despite the fact that SSI is basically able to differentiate the elastic properties of MCH, a great variability among different patients could be a major issue. This variability depends on the fact that some other variables play a role in SSI calculation in addition to elastic properties of material: the leg position during measurements, the configuration and consistency at the measuring site of the leg, the individual muscle strength, the presence of fat and others.7 A new standardized method to measure the stiffness on a mannequin leg was reported8 which presents the advantages to be simple, highly reproducible, easily available and cheap. If this method will be widely adopted, it would also be possible to avoid that every com- pany producing MCH measure stiffness with different systems thereby increasing the con- fusion. In order to differentiate between meas- urement in vivo and in laboratory (lab) the so called in vitro measurement, it was proposed to name the in vitro calculation not anymore stiffness in vitro, but resistance.9 Regarding the measuring site on the leg, the B1 point described in the ICC consensus paper6 was brilliantly confirmed as the most suitable site for stiffness measurement.10 Stiffness, together with pressure and hys- teresis,11 is an important parameter for effec- tiveness combined with comfort of MCH. Neumann’s paper rises two important points.11 One is the relevance of another indicator of stiffness the so-called dynamic stiffness index (DSI) requiring complex measuring systems. Nevertheless, an excellent correlation between SSI and DSI could be shown by using this lab equipment12 but also in vivo during muscle exercise.2,13 This supports the idea that in vivo testing is a valuable tool for assessing the elas- tic properties especially in connection with clinical effectiveness of compression devices. The second point is the importance of the hys- teresis of different compression materials. Hysteresis can be measured only in the lab and remains something obscure for the clinicians whereas they should receive full information by companies on this parameter. An ideal compression device should exert a low, comfortable pressure during rest, with a strong or very strong pressure14 during stand- ing and working in order to counteract ambu- latory venous hypertension (effective). Such a device would have a very high SSI but, unfortu- nately, it doesn’t exist yet. Inelastic material presenting high stiffness comes close to an ideal compression device;15 especially when pressure decreases after some hours from application in the supine position, the differ- ence between standing and supine pressure is very high exerting an effective massaging effect on the leg during walking and improving significantly the hemodynamic impairment of chronic venous insufficiency. Elastic material, exerting a sustained pressure, not very differ- ent between supine and standing position or during muscle exercise, shows a small improvement on the impaired venous hemody- namics which is always significantly smaller than that from inelastic material.16,17 Actually stiff materials exerting strong or very strong pressure showed to be clinically effective in ulcer treatment16,18,19 when a sig- nificant impact on venous hemodynamics is very important and also in lymphoedema.20 Pressure and stiffness can be critically reduced in some areas of the leg with concave rather than convex shape as this is the case in the retro-malleolar space. Unfortunately this is a critical area where often venous ulcers occur. It has been shown that in this region the pres- sure as well as stiffness can be close to zero as the pressure doesn’t increase in standing posi- tion or during muscle activity. Pressure and stiffness in these areas can be significantly increased by applying local compression straps21 which greatly improve the clinical out- come.22 An increase of pressure and stiffness can be achieved also at thigh level by means of eccentric devices, which are able to compress the thigh veins otherwise difficult to com- press.23 In this region higher pressure and stiffness leads to better outcome following sur- gical or endovascular procedures on the great saphenous vein.24,25 In conclusion it is important to realize that stiffness can be mainly considered as a surro- gate indicator of comfort and effectiveness. The higher the stiffness the greater comfort and effectiveness in improving the clinical out- comes. Stiffness is very high only with inelas- Correspondence: Giovanni Mosti, Angiology Department, Clinica MD Barbantini, Lucca, Italy. E-mail: jmosti@tin.it Key words: International Compression Club, stiff- ness, compression devices, conference presenta- tion. Conference presentation: part of this paper was presented at the International Compression Club (ICC) Meeting on Stiffness of Compression Devices, 2012 May 25, Vienna, Austria (http://www.icc-compressionclub.com/). Received for publication: 15 November 2012. Revision received: 23 January 2013. Accepted for publication: 28 January 2013 This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0). ©Copyright G. Mosti, 2013 Licensee PAGEPress, Italy Veins and Lymphatics 2013; 2:e1 doi:10.4081/vl.2013.e1 No n- co mm er cia l u se on ly Editorial [page 2] [Veins and Lymphatics 2013; 2:e1] tic material, or multilayer systems and can be enhanced by straps applied in a fan distribu- tion or by eccentric compression devices in the leg segment that need to be treated. In vivo measurement techniques must be better defined in order to minimize the vari- ability; a parallel match with the lab assess- ments is a mandatory target for future researches. Only in this way the stiffness effective value will scientifically demonstrate to correspond to the great impact that already empirically presents in our everyday clinical practice. References 1. European Committee for Standardization (CEN). Non active medical devices. Working Group 2 ENV 12718: European Pre-standard ‘Medical Compression Hosiery.’ CEN TC 205. Brussels: CEN; 2001. 2. Mosti G, Mattaliano V. Simultaneous changes of leg circumference and inter- face pressure under different compression bandages. Eur J Vasc Endovasc Surg 2007; 33:476-82. 3. Stolk R, Wengen Van Der-Franken CPM, Neumann HAM. A method for measuring the dynamic behaviour of medical com- pression hosiery during walking. Dermatol Surg 2004;30:729-36. 4. Wienert V, Hansen R. Anmessen von medi- zinischen kompressionsstrümpfen am liegenden oder am stehenden patienten? Phlebologie 1992;21:236-8. 5. Partsch H. The static stiffness index: a simple method to assess the elastic prop- erty of compression material in vivo. Dermatol Surg 2005;31:625-30. 6. Partsch H, Clark M, Bassez S, et al. Measurement of lower leg compression in vivo: reccommendations for the perform- ance of measurements of interface pres- sure and stiffness. Dermatol Surg 2006;32:224-33. 7. Schuren J, Bichel J. Sub-bandage dynam- ics: stiffness unraveled. Veins and Lymphatics 2013;2:e2. 8. Hirai M, Partsch H. The Mannequin-leg: a new instrument to assess stiffness of com- pression materials. Veins and Lymphatics 2013;2:e3. 9. Cornu-Thénard A, Benigni J-P, Uhl J-F. Terminology: resistance or stiffness for medical compression stockings? Veins and Lymphatics 2013;2:e4. 10. Uhl J-F, Benigni J-P, Cornu-Thénard A. Where should be stiffness measured in vivo? Veins and Lymphatics 2013;2:e5. 11. Neumann HAM. Elasticity, hysteresis and stiffness: the magic triangle. Veins and Lymphatics 2013;2:e6. 12. van der Wegen-Franken K, Tank B, Neumann M. Correlation between the stat- ic and dynamic stiffness indices of med- ical elastic compression stockings. Dermatol Surg 2008;34:1477-85. 13. Mosti G, Mattaliano V, Partsch H. Inelastic compression increases venous ejection fraction more than elastic bandages in patients with superficial venous reflux. Phlebology 2008;23:287-94. 14. Partsch H, Clark M, Mosti G, et al. Classification of compression bandages: practical aspects. Dermatol Surg 2008;34:600-9. 15. Andriessen A, Abel M. Experimental study on efficacy of compression systems with a high static stiffness index for treatment of venous ulcer patients. Veins and Lymphatics 2013;2:e8. 16. Mosti G. Relevance of stiffness of com- pression material on venous hemodynam- ics and edema. Veins and Lymphatics 2013;2:e9. 17. Bender DJ, Fronek H, Arkans E. Quantified hemodynamics of compression garments. Veins and Lymphatics 2013;2:e10. 18. Wong IK, Andriessen A, Lee DT, et al. Randomized controlled trial comparing treatment outcome of two compression bandaging systems and standard care without compression in patients with venous leg ulcers. J Vasc Surg 2012;55: 1376-85. 19. Mosti G, Crespi A, Mattaliano V. Compa - rison between a new, two-component com- pression system with zinc paste bandages for leg ulcer healing: a prospective, multi- center, randomized, controlled trial moni- toring sub-bandage pressures. Wounds 2011;23:126-34. 20. Schingale F-J, Partsch H. Alginate hydro- colloid impregnated zinc paste bandages- an alternative in the management of lym- phoedema? Veins and Lymphatics 2013;2: e11. 21. Hopkins A, Worboys F, Partsch H. The use of strapping to increase local pressure: reporting of a sub-bandage pressure study. Veins and Lymphatics 2013;2:e12. 22. Hopkins A, Worboys F, Bull R, Farrelly I. Compression strapping: the development of a novel compression technique to enhance compression therapy and healing for ‘hard-to-heal’ leg ulcers. Int Wound J 2011;8:474-83. 23. Partsch H, Mosti G, Mosti F. Narrowing of leg veins under compression demonstrat- ed by magnetic resonance imaging (MRI). Int Angiol 2010;29:408-10. 24. Mosti G, Mattaliano V, Arleo S, Partsch H. Thigh compression after great saphenous surgery is more effective with high pres- sure. Int Angiol 2009;28:274-80. 25. Lugli M, Cogo A, Guerzoni S, et al. Effects of eccentric compression by a crossed-tape technique after endovenous laser ablation of the great saphenous vein: a randomized study. Phlebology 2009;24:151-6.No n- co mm er cia l u se on ly