# bib

id: cord-003888-lgutt1r9
author: Lauterbach, Sarah E.
date: 2019-09-18
extension: .txt
mime: text/plain
words: 2550
sentence: 96
flesch: 33
cache: cache/cord-003888-lgutt1r9.txt
txt: txt/cord-003888-lgutt1r9.txt
title:
  Assessing exhibition swine as potential disseminators of infectious disease through the detection of five respiratory pathogens at agricultural exhibitions

summary:
  Measures to minimize influenza transmission at swine exhibitions Subclinical influenza virus A infections in pigs exhibited at agricultural fairs Characterization of an influenza A virus isolated from pigs during an outbreak of respiratory disease in swine and people during a county fair in the United States Simultaneous infection of pigs and people with triple-reassortant swine influenza virus H1N1 at a U.S. county fair Active surveillance for influenza A virus among swine, midwestern United States The pig as a mixing vessel for influenza viruses: human and veterinary implications Evolutionary Dynamics of influenza A viruses in US exhibition swine Outbreak of Influenza A(H3N2) variant virus infections among persons attending agricultural fairs housing infected swine-Michigan and Ohio Outbreak of influenza A (H3N2) variant virus infection among attendees of an agricultural fair Movement patterns of exhibition swine and associations of influenza A virus infection with swine management practices Potential role of noncommercial swine populations in the epidemiology and control of porcine reproductive and respiratory syndrome virus Introduction, evolution, and dissemination of influenza A viruses in exhibition swine in the United States during 2009 to 2013 Porcine hemagglutinating encephalomyelitis virus and respiratory disease in exhibition swine Complete genome sequence of an influenza D virus strain identified in a pig with subclinical infection in the United States Widespread detection and characterization of porcine parainfluenza virus 1 in pigs in the USA Nasal wipes for influenza A virus detection and isolation from swine Utility of snout wipe samples for influenza A virus surveillance in exhibition swine populations Prevalence of influenza A virus in exhibition swine during arrival at agricultural fairs Isolation of a novel swine influenza virus from Oklahoma in 2011 which is distantly related to human influenza C viruses Two cases of flu linked to contact with swine at Fowlerville fair. key: cord-003888-lgutt1r9 authors: Lauterbach, Sarah E.; Nelson, Sarah W.; Robinson, Meghann E.; Lorbach, Josh N.; Nolting, Jacqueline M.; Bowman, Andrew S. title: Assessing exhibition swine as potential disseminators of infectious disease through the detection of five respiratory pathogens at agricultural exhibitions date: 2019-09-18 journal: Vet Res DOI: 10.1186/s13567-019-0684-5 sha: doc_id: 3888 cord_uid: lgutt1r9 Widespread geographic movement and extensive comingling of exhibition swine facilitates the spread and transmission of infectious pathogens.


id: cord-330554-xg49foch
author: Tanaka, Yoshikazu
title: Suppression of feline coronavirus replication in vitro by cyclosporin A
date: 2012-04-30
extension: .txt
mime: text/plain
words: 3096
sentence: 121
flesch: 39
cache: cache/cord-330554-xg49foch.txt
txt: txt/cord-330554-xg49foch.txt
summary:
  These findings show that CsA does not influence the NF-AT pathway in fcwf-4 cells and that the inhibition of FIPV RNA replication by CsA is independent of the calcineurin NF-AT pathway. Consequently, the action of CsA on intracellular FIPV replication does not involve the activation of interferonstimulated genes on fcwf-4 cells.


id: cord-263785-0iift8zy
author: Zhang, Xiaorong
date: 2020-07-31
extension: .txt
mime: text/plain
words: 3703
sentence: 131
flesch: 44
cache: cache/cord-263785-0iift8zy.txt
txt: txt/cord-263785-0iift8zy.txt
title:
  Evaluation of the reproductive system development and egg-laying performance of hens infected with TW I-type infectious bronchitis virus

summary:
  In: Walker JM (ed) Methods in molecular biology Egg quality traits differ in hens selected for high as compared with low antibody response to sheep red blood cells Development and evaluation of a real-time Taqman RT-PCR assay for the detection of infectious bronchitis virus from infected chickens Emergence of novel nephropathogenic infectious bronchitis viruses currently circulating in Chinese chicken flocks Characterization of the complete genome, antigenicity, pathogenicity, tissue tropism, and shedding of a recombinant avian infectious bronchitis virus with a ck/CH/LJL/140901-like backbone and an S2 fragment from a 4/91-like virus Induction of cystic oviducts and protection against early challenge with infectious bronchitis virus serotype D388 (genotype QX) by maternally derived antibodies and by early vaccination Comparative histopathology and immunohistochemistry of QX-like, Massachusetts and 793/B serotypes of infectious bronchitis virus infection in chickens Pathogenicity differences between a newly emerged TW-like strain and a prevalent QX-like strain of infectious bronchitis virus Safety and efficacy of an attenuated Chinese QX-like infectious bronchitis virus strain as a candidate vaccine Genetic and pathologic characterization of a novel recombinant TC07-2-type avian infectious bronchitis virus Pathogenicity differences between QX-like and Mass-type infectious bronchitis viruses Preparation and protective efficacy of a chicken embryo kidney cell-attenuation GI-19/QX-like avian infectious bronchitis virus vaccine A Multi-omics study of chicken infected by nephropathogenic infectious bronchitis virus Effects of avian infectious bronchitis virus antigen on eggshell formation and immunoreaction in hen oviduct Effects of the routine multiple vaccinations on the expression of innate immune molecules and induction of histone modification in ovarian cells of layer chicks Coronavirus avian infectious bronchitis virus Evolution of infectious bronchitis virus in China over the past two decades Recombination in avian gamma-coronavirus infectious bronchitis virus Induction of IBV strain-specific neutralizing antibodies and broad spectrum protection in layer pullets primed with IBV Massachusetts (Mass) and 793B vaccines prior to injection of inactivated vaccine containing Mass antigen The long view: 40 years of infectious bronchitis research A long-term study of the pathogenesis of infection of fowls with three strains of avian infectious bronchitis virus Re-excretion of infectious bronchitis virus in chickens induced by cyclosporin Phylogenetic analysis of the S1 glycoprotein gene of infectious bronchitis viruses isolated in China during Epidemiology and characterization of avian infectious bronchitis virus strains circulating in southern China during the period from Serotype, antigenicity, and pathogenicity of a naturally recombinant TW I genotype infectious bronchitis coronavirus in China Altered pathogenicity of a tl/CH/LDT3/03 genotype infectious bronchitis coronavirus due to natural recombination in the 5′-17 kb region of the genome Genetics, antigenicity and virulence properties of three infectious bronchitis viruses isolated from a single tracheal sample in a chicken with respiratory problems Characterization and analysis of an infectious bronchitis virus strain isolated from southern China in 2013 Molecular epidemiology of infectious bronchitis virus in China between 2009 and 2011, and development of recombinant vaccine using Marek's disease virus as vector Development and efficacy of an attenuated TW-I like infectious bronchitis virus strain as a candidate live vaccine for chickens in China Coronaviruses: methods and protocols.


id: cord-335215-h9p4kmss
author: Follet, Jérôme
date: 2011-12-02
extension: .txt
mime: text/plain
words: 4343
sentence: 205
flesch: 48
cache: cache/cord-335215-h9p4kmss.txt
txt: txt/cord-335215-h9p4kmss.txt
title:
  Cryptosporidium infection in a veal calf cohort in France: molecular characterization of species in a longitudinal study

summary:
  in neonatal calves in Northern Ireland Molecular epidemiology of Cryptosporidium subtypes in cattle in England Cryptosporidium genotype and subtype distribution in raw wastewater in Shanghai, China: evidence for possible unique Cryptosporidium hominis transmission Molecular epidemiology of cryptosporidiosis: an update Cryptosporidium parvum mixed genotypes detected by PCR-restriction fragment length polymorphism analysis Identification of genotypically mixed Cryptosporidium parvum populations in humans and calves New view on the agespecificity of pig Cryptosporidium by species-specific primers for distinguishing Cryptosporidium suis and Cryptosporidium pig genotype II A multiplex polymerase chain reaction assay to simultaneously distinguish Cryptosporidium species of veterinary and public health concern in cattle Characteristics of Cryptosporidium transmission in preweaned dairy cattle in Henan Cryptosporidium parvum infection in bovine neonates: dynamic clinical, parasitic and immunologic patterns Resistance of calves to Cryptosporidium parvum: effects of age and previous exposure Cryptosporidium parvum in calves: kinetics and immunoblot analysis of specific serum and local antibody responses (immunoglobulin A in cattle in Michigan: implications for understanding the transmission dynamics Risk factors associated with Cryptosporidium parvum infection in cattle Cryptosporidium and Giardia in different age groups of Danish cattle and pigs-occurrence and management associated risk factors Epidemiology of Cryptosporidium spp.


id: cord-290593-vhmi2559
author: Lannes, Nils
date: 2012-08-30
extension: .txt
mime: text/plain
words: 4422
sentence: 200
flesch: 44
cache: cache/cord-290593-vhmi2559.txt
txt: txt/cord-290593-vhmi2559.txt
title:
  Interplay of foot-and-mouth disease virus, antibodies and plasmacytoid dendritic cells: virus opsonization under non-neutralizing conditions results in enhanced interferon-alpha responses

summary:
  [8] to form FMDV immune complexes, we were interested to determine the relationship between serum concentration and IFN-α enhancement. Both uncomplexed virus and immune complexed virus stimulated pDC via Toll-like receptor 7.


id: cord-269531-7gy4epzo
author: Kumar, Pankaj
title: Proteomic analysis of purified turkey adenovirus 3 virions
date: 2015-07-09
extension: .txt
mime: text/plain
words: 4336
sentence: 191
flesch: 33
cache: cache/cord-269531-7gy4epzo.txt
txt: txt/cord-269531-7gy4epzo.txt
summary:
  Using MS based approaches, a number of host proteins have been reported to be incorporated into RNA viruses (human immunodeficiency virus-1 Non availability of turkey host protein specific antisera made it difficult to verify the packaging of host proteins in TAdV-3 virions.


id: cord-004400-li1sc47z
author: Ma, Jingjiao
date: 2020-02-24
extension: .txt
mime: text/plain
words: 4865
sentence: 157
flesch: 40
cache: cache/cord-004400-li1sc47z.txt
txt: txt/cord-004400-li1sc47z.txt
title:
  Acetylation at K108 of the NS1 protein is important for the replication and virulence of influenza virus

summary:
  To detect the IFN-β antagonistic ability of NS1 proteins, 293T cells were transfected with the indicated NS1 expression plasmids (0.2 μg/well) together with a plasmid expressing firefly luciferase under the control of the IFN-β promoter (pGL-IFN-β-LUC, 0.2 μg/well), the Renilla luciferase expressing plasmid pRL-TK (0.07 μg/ well), and the IFN-β stimulator poly(I:C) (0.2 μg/well) or a plasmid expressing the active caspase recruitment domain (CARD) of RIG-I (pcDNA-RIG-I 0.2 μg/well), pcDNA-MAVS (0.2 μg/well), pcDNA-TBK1 (0.2 μg/well) or pcDNA-IRF3 (0.2 μg/well) as described previously [34] . This result indicated that the deacetylation-mimic K108R substitution retained NS1 protein in the cytoplasm of infected cells, suggesting that the acetylated K108 residue is important for the nuclear localization of the NS1 protein ( Figures 5A-C ).


id: cord-264888-h560slug
author: Goossens, Evy
date: 2016-04-27
extension: .txt
mime: text/plain
words: 5362
sentence: 219
flesch: 39
cache: cache/cord-264888-h560slug.txt
txt: txt/cord-264888-h560slug.txt
title:
  The C-terminal domain of Clostridium perfringens alpha toxin as a vaccine candidate against bovine necrohemorrhagic enteritis

summary:
  In this study, we used the calf intestinal loop model to evaluate the vaccine potential of C. perfringens alpha toxin. Although antibodies against C. perfringens alpha toxin neutralize alpha toxin activity and C. perfringens-induced endothelial cytotoxicity in vitro, antibodies against alpha toxin alone are inadequate for complete neutralization of C. perfringens-induced necrosis in the intestinal loop model of bovine necrohemorrhagic enteritis.


id: cord-319685-dw0qsl4s
author: Porter, Emily
date: 2014-04-25
extension: .txt
mime: text/plain
words: 5692
sentence: 208
flesch: 52
cache: cache/cord-319685-dw0qsl4s.txt
txt: txt/cord-319685-dw0qsl4s.txt
title:
  Amino acid changes in the spike protein of feline coronavirus correlate with systemic spread of virus from the intestine and not with feline infectious peritonitis

summary:
  Overall, a leucine codon was found in the majority (39/43; 91%) of FIP tissue samples, but a significant number had a methionine codon (4/43; 9%). Second, a significant number (9%) of FIP tissue samples had a methionine codon at this position.


id: cord-003216-5qioku84
author: Rehman, Zaib Ur.
title: Pathobiology of Avian avulavirus 1: special focus on waterfowl
date: 2018-09-19
extension: .txt
mime: text/plain
words: 5617
sentence: 220
flesch: 36
cache: cache/cord-003216-5qioku84.txt
txt: txt/cord-003216-5qioku84.txt
summary:
  Molecular characterization and epitope mapping of fusion (F) and hemagglutinin (HN) genes of avian paramyxovirus serotype i from peacocks in Pakistan Supplementation of vitamin e protects chickens from Newcastle disease virus-mediated exacerbation of intestinal oxidative stress and tissue damage Genetic diversity and mutation of avian paramyxovirus serotype 1 (Newcastle disease virus) in wild birds and evidence for intercontinental spread Newcastle disease in geese: natural occurrence and experimental infection Development and field application of a competitive enzyme-linked immunosorbent assay for detection of Newcastle disease virus antibodies in chickens and ducks Isolation and identification of paramyxovirus type 1 from duck Genomic sequence of an avian paramyxovirus type 1 strain isolated from Muscovy duck (Cairina moschata) in China Phylogenetic and pathotypical analysis of two virulent Newcastle disease viruses isolated from domestic ducks in China Genome sequence of a virulent genotype III Newcastle disease virus isolated from laying ducks in China Pathotypical and genotypical characterization of strains of Newcastle disease virus isolated from outbreaks in chicken and goose flocks in some regions of China during Generation of velogenic Newcastle disease viruses from a nonpathogenic waterfowl isolate by passaging in chickens Evolution of Newcastle disease virus quasispecies diversity and enhanced virulence after passage through chicken air sacs Phylogenetic and pathotypic characterization of Newcastle disease viruses circulating in South China and transmission in different birds Molecular and antigenic characteristics of Newcastle disease virus isolates from domestic ducks in China Evaluation of histopathological changes, viral load and immune function of domestic geese infected with Newcastle disease virus Phylogenetic relationships and pathogenicity variation of two Newcastle disease viruses isolated from domestic ducks in southern China Characterization and sequencing of a genotype VIId Newcastle disease virus isolated from laying ducks in Identification of a genotype VIId Newcastle disease virus isolated from sansui sheldrake ducks in Guizhou province Complete genome sequences of Newcastle disease virus strains isolated from three different poultry species in China Serologic and virologic survey for evidence of infection with velogenic Newcastle disease virus in Chinese duck farms Characterization of velogenic Newcastle disease viruses isolated from dead wild birds in Serbia during Molecular epidemiological analysis of Newcastle disease virus isolated in China in 2005 Characterization of Newcastle disease virus isolated from waterfowl in China Antigenic and genotypical characterization of Newcastle disease viruses isolated in Taiwan between Association of RIG-I with innate immunity of ducks to influenza Goose RIG-I functions in innate immunity against Newcastle disease virus infections The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses Promoter structures and differential responses to viral and nonviral inducers of chicken type I interferon genes Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity Viral evasion and subversion of pattern-recognition receptor signalling The specific and essential role of MAVS in antiviral innate immune responses Essential role of IPS-1 in innate immune responses against RNA viruses The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter Histopathological alterations in immune organs of chickens and ducks after experimental infection with virulent 9a5b newcastle disease virus Expression of RIG-I, IRF3, IFN-beta and IRF7 determines resistance or susceptibility of cells to infection by Newcastle Disease Virus Newcastle disease virus infection in chicken embryonic fibroblasts but not duck embryonic fibroblasts is associated with elevated host innate immune response Identification of 2′-5′-oligoadenylate synthetase-like gene in goose: gene structure, expression patterns, and antiviral activity against Newcastle disease virus Experimental infection of duck origin virulent Newcastle disease virus strain in ducks Lack of detection of host associated differences in Newcastle disease viruses of genotype VIId isolated from chickens and geese Isolation and preliminary identification of a virulent Newcastle disease virus isolate of duck origin Molecular characterization and expression analysis of the duck viperin gene Infection of goose with genotype VIId Newcastle disease virus of goose origin elicits strong immune responses at early stage Experimental co-infections of domestic ducks with a virulent Newcastle disease virus and low or highly pathogenic avian influenza viruses Effect of immunosuppression on newcastle disease virus persistence in ducks with different immune status Antigenic variation between Newcastle disease viruses of goose and chicken origin Molecular epidemiological investigation of Newcastle disease virus from domestic ducks in Korea A preliminary study of the role of ducks in the transmission of Newcastle disease virus to in-contact rural free-range chickens The response of ducks to V4 Newcastle disease virus and its transmission to contact ducks and domestic chickens An epizootiological report of the re-emergence and spread of a lineage of virulent Newcastle disease virus into Eastern Europe Passaging of a Newcastle disease virus pigeon variant in chickens results in selection of viruses with mutations in the polymerase complex enhancing virus replication and virulence Characterisation of an antigenically unusual virus responsible for two outbreaks of Newcastle disease in the Republic of Ireland in 1990 Phylogenetic diversity among low-virulence newcastle disease viruses from waterfowl and shorebirds and comparison of genotype distributions to those of poultry-origin isolates Multiplex RT-PCR for rapid detection and differentiation of class I and class II Newcastle disease viruses Avian paramyxovirus serotype-1: a review of disease distribution, clinical symptoms, and laboratory diagnostics Surveillance of avirulent Newcastle disease viruses at live bird markets in eastern China during 2008-2012 reveals a new sub-genotype of class I virus A review of virulent Newcastle disease viruses in the United States and the role of wild birds in viral persistence and spread Characterization of complete genome sequence of genotype VI and VII velogenic Newcastle disease virus from Japan Potential of genotype VII Newcastle diseaseviruses to cause differential infections in chickens and ducks Genetic, pathogenic and antigenic diversity of Newcastle disease viruses in Phylogenetic analysis of Newcastle disease viruses isolated from wild birds in the Poyang Lake region of China Temporal dynamics, diversity, and interplay in three components of the virodiversity of a Mallard population: influenza A virus, avian paramyxovirus and avian coronavirus Comparison of viral shedding following vaccination with inactivated and live Newcastle disease vaccines formulated with wild-type and recombinant viruses Evolutionary dynamics of Newcastle disease virus Imperfect vaccination can enhance the transmission of highly virulent pathogens Newcastle disease: evolution of genotypes and the related diagnostic challenges A vaccine candidate of attenuated genotype VII Newcastle disease virus generated by reverse genetics Genotyping of Newcastle disease viruses isolated from 2001 to 2007 in Japan Avian influenza virus and Newcastle disease virus (NDV) surveillance in commercial breeding farm in China and the characterization of Class I NDV isolates Molecular epidemiology of outbreak-associated and wild-waterfowl-derived newcastle disease virus strains in Finland, including a novel class I genotype Genomic characterizations of a Newcastle disease virus isolated from ducks in live bird markets in China Complete genome sequences of two subgenotype 1b Newcastle disease viruses isolated from Sansui sheldrake Ducks in Guizhou Wood ducks (Aix sponsa) as potential reservoirs for avian influenza and avian paramyxoviruses Genomic characterization of the first class I Newcastle disease virus isolated from the mainland of China Surveillance for avirulent Newcastle disease viruses in domestic ducks (Anas platyrhynchos and Cairina moschata) at live bird markets in Eastern China and characterization of the viruses isolated Whole genome sequencing and biological characterization of Duck/JS/10, a new lentogenic class I Newcastle disease virus Genetic characterization and evolutionary analysis of Newcastle disease virus isolated from domestic duck in South Korea Complete genome sequence of genotype IB Newcastle disease virus isolated from a mallard (Anas platyrhynchos) in Russia Prevalence of avian paramyxovirus type 1 in Mallards during autumn migration in the western Baltic Sea region Characterization of newcastle disease viruses in wild and domestic birds in Luxembourg from Genetic diversity of newcastle disease virus in wild birds and pigeons in West Africa Exchange of Newcastle disease viruses in Korea: the relatedness of isolates between wild birds, live bird markets, poultry farms and neighboring countries Monitoring of wild birds for Newcastle disease virus in north Queensland Molecular epidemiologic investigation of lentogenic Newcastle disease virus from domestic birds at live bird markets in Korea Characterization of avian paramyxovirus type 1 from migratory wild birds in chickens Surveillance and characterization of Newcastle disease viruses isolated from northern pintail (Anas acuta) in Japan during 2006-09 Genetic characterization and evolutionary analysis of 4 Newcastle disease virus isolate full genomes from waterbirds in South China during Phylogenetic analysis of Newcastle disease viruses isolated from waterfowl in the upper midwest region of the United States Orthomyxo-, paramyxo-and flavivirus infections in wild waterfowl in Finland Characterization of Newcastle disease virus isolated from northern pintail (Anas acuta) in Japan Pathotyping and genetic characterization of avian avulavirus-1 from domestic and wild waterfowl, geese and black swans in Pakistan Complete genome sequences of two Newcastle disease virus strains isolated from a wild duck and a pigeon in Russia Complete genome sequence of a virulent Newcastle disease virus strain isolated from a clinically healthy duck (Anas platyrhynchos domesticus) in Pakistan Genomic and biological characterization of Newcastle disease viruses isolated from migratory mallards (Anas platyrhynchos) Identification of a genotype IX Newcastle disease virus in a Guangxi white duck Potentially virulent Newcastle disease viruses are maintained in migratory waterfowl populations Pathotypical characterization and molecular epidemiology of Newcastle disease virus isolates from different hosts in China from 1996 to Genetic, antigenic, and pathogenic characteristics of Newcastle disease viruses isolated from geese in China Biological characteristics and sequence analysis of fusion genes of Newcastle disease virus isolates Isolation, identification, and sequencing of a goose-derived Newcastle disease virus and determination of its pathogenicity Genomic analysis of Newcastle disease virus strain NA-1 isolated from geese in China Genetic diversity of Newcastle disease viruses isolated from domestic poultry species in Eastern China during Complete genome sequences of new emerging Newcastle disease virus strains isolated from china


id: cord-295661-v3q1spmm
author: Resende, Talita Pilar
title: Evaluation of mouse enteroids as a model for Lawsonia intracellularis infection
date: 2019-07-19
extension: .txt
mime: text/plain
words: 5464
sentence: 206
flesch: 26
cache: cache/cord-295661-v3q1spmm.txt
txt: txt/cord-295661-v3q1spmm.txt
summary:
  To determine whether L. intracellularis infection induces changes in the proliferation and differentiation of enteroid epithelial cells, as observed in the swine intestine, we evaluated expression of Ki-67, Sox9 and Muc2 in enteroids harvested at 1, 3 and 7 dpi relative to expression in enteroids at 0 dpi. B L. intracellularis antigen is associated with cell debris (arrow heads) and in close proximity to enteroid cells (black arrows), ×200.


id: cord-000172-um0ds7dh
author: Paul, Mathilde
date: 2009-12-16
extension: .txt
mime: text/plain
words: 6000
sentence: 256
flesch: 51
cache: cache/cord-000172-um0ds7dh.txt
txt: txt/cord-000172-um0ds7dh.txt
title:
  Anthropogenic factors and the risk of highly pathogenic avian influenza H5N1: prospects from a spatial-based model

summary:
  Some aspects of the role of human activities in HPAI risk were recently reported from Vietnam Medium average altitude in subdistricts associated with low RR was found to constitute a kind of protective factor regarding HPAI risk.


id: cord-278635-vwdxr1bl
author: Świętoń, Edyta
date: 2020-08-28
extension: .txt
mime: text/plain
words: 5436
sentence: 216
flesch: 41
cache: cache/cord-278635-vwdxr1bl.txt
txt: txt/cord-278635-vwdxr1bl.txt
title:
  Low pathogenic avian influenza virus isolates with different levels of defective genome segments vary in pathogenicity and transmission efficiency

summary:
  A defective interfering influenza RNA inhibits infectious influenza virus replication in human respiratory tract cells: a potential new human antiviral Cell culture-based production of defective interfering particles for influenza antiviral therapy Influenza virus DI particles: Defective interfering or delightfully interesting? Characterization of virulent and avirulent A/chicken/Pennsylvania/83 influenza A viruses: potential role of defective interfering RNAs in nature Defective viral genomes arising in vivo provide critical danger signals for the triggering of lung antiviral immunity Reduced accumulation of defective viral genomes contributes to severe outcome in influenza virus infected patients Interfering vaccine: a novel antiviral that converts a potentially virulent infection into one that is subclinical and immunizing Protection of mice from lethal influenza: evidence that defective interfering virus modulates the immune response and not virus multiplication Defective interfering influenza virus confers only short-lived protection against influenza virus disease: evidence for a role for adaptive immunity in DI virus-mediated protection in vivo Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing Defective interfering virus associated with A/Chicken/Pennsylvania/83 influenza virus Avian influenza in Poland Manual of diagnostic tests and vaccines for terrestrial animals chapter Single-reaction genomic amplification accelerates sequencing and vaccine production for classical and Swine origin human influenza a viruses Viral population analysis and minority-variant detection using short read next-generation sequencing Trimmomatic: a flexible trimmer for Illumina sequence data Fast and accurate short read alignment with Burrows-Wheeler transform The sequence alignment/map format and SAMtools VarScan: variant detection in massively parallel sequencing of individual and pooled samples Droplet digital PCR: A novel method for detection of influenza virus defective interfering particles convenient online submission • thorough peer review by experienced researchers in your field • rapid publication on acceptance • support for research data, including large and complex data types • gold Open Access which fosters wider collaboration and increased citations maximum visibility for your research: over 100M website views per year • At BMC Development and evaluation of a one-step real-time RT-PCR assay for universal detection of influenza A viruses from avian and mammal species Identification of sensitive and specific avian influenza polymerase chain reaction methods through blind ring trials organized in the European Union Pathogenesis and pathobiology of avian influenza virus infection in birds Unexpected infection outcomes of China-origin H7N9 low pathogenicity avian influenza virus in turkeys Infectivity, transmission and pathogenicity of H5 highly pathogenic avian influenza clade 2344 (H5N8 and H5N2) United States index viruses in Pekin ducks and Chinese geese Different pathogenicity of two strains of clade 2.3.4.4c H5N6 highly pathogenic avian influenza viruses bearing different PA and NS gene in domestic ducks Ghedin E; INSIGHT FLU002 Study Group; INSIGHT FLU003 Study Group (2013) In: Swayne DE (ed) Diseases of poultry Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis Population diversity and collective interactions during influenza virus infection The defective component of viral populations Incomplete forms of influenza virus Functional characterization of naturally occurring variants of human hepatitis B virus containing the core internal deletion mutation Defective interfering viral particles in acute dengue infections Internally deleted WNV genomes isolated from exotic birds in New Mexico: function in cells, mosquitoes, and mice SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection Influenza defective interfering viral RNA is formed by internal deletion of genomic RNA Segment-specific noncoding sequences of the influenza virus genome RNA are involved in the specific competition between defective interfering RNA and its progenitor RNA segment at the virion assembly step Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad-spectrum antivirals?


id: cord-025152-3wqtu9ey
author: Lee, Ji Eun
date: 2020-05-24
extension: .txt
mime: text/plain
words: 6066
sentence: 216
flesch: 42
cache: cache/cord-025152-3wqtu9ey.txt
txt: txt/cord-025152-3wqtu9ey.txt
title:
  Bacillus subtilis spores as adjuvants against avian influenza H9N2 induce antigen-specific antibody and T cell responses in White Leghorn chickens

summary:
  This result is in line with a previous study that demonstrating the ability of B. subtilis spores to increase the level of T cell responses [35] . key: cord-025152-3wqtu9ey authors: Lee, Ji Eun; Kye, Yoon-Chul; Park, Sung-Moo; Shim, Byoung-Shik; Yoo, Sungsik; Hwang, Eunmi; Kim, Hyungkuen; Kim, Sung-Jo; Han, Seung Hyun; Park, Tae Sub; Park, Byung-Chul; Yun, Cheol-Heui title: Bacillus subtilis spores as adjuvants against avian influenza H9N2 induce antigen-specific antibody and T cell responses in White Leghorn chickens date: 2020-05-24 journal: Vet Res DOI: 10.1186/s13567-020-00788-8 sha: doc_id: 25152 cord_uid: 3wqtu9ey Low-pathogenicity avian influenza H9N2 remains an endemic disease worldwide despite continuous vaccination, indicating the need for an improved vaccine strategy.


id: cord-326723-jiauk4fq
author: Risalde, María A
date: 2013-03-18
extension: .txt
mime: text/plain
words: 5804
sentence: 214
flesch: 38
cache: cache/cord-326723-jiauk4fq.txt
txt: txt/cord-326723-jiauk4fq.txt
title:
  Pathogenic mechanisms implicated in the intravascular coagulation in the lungs of BVDV-infected calves challenged with BHV-1

summary:
  The role of nitric oxide synthases in lung inflammation Veterinary Immunology: An Introduction Adenoviral-mediated gene transfer of nitric oxide synthase isoforms and vascular cell proliferation Suppression of pro-inflammatory cytokines, iNOS, and COX-2 expression by brown algae Sargassum micracanthum in RAW 264.7 macrophages Immunohistochemical demonstration of cyclooxygenase-2 (COX-2) and prostaglandin receptors EP2 and FP expression in the bovine intercaruncular uterine wall around term Inflammatory cytokines enhance the interaction of mannheimia haemolytica leukotoxin with bovine peripheral blood neutrophils in vitro Effect of experimental infection of cattle with bovine herpesvirus-1 (BHV-1) on the ex vivo interaction of bovine leukocytes with mannheimia (pasteurella) haemolytica leukotoxin Secondary in vitro B lymphocyte (antibody) response to microbial antigens: use in appraisal of vaccine immunogenicity and cytokine immunoregulation Tumor necrosis factor as a mediator of inflammation in influenza A viral pneumonia Increased pulmonary secretion of tumor necrosis factoralpha in calves experimentally infected with bovine respiratory syncytial virus Pulmonary expression of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-8 in the acute phase of bovine pneumonic pasteurellosis Bovine herpesvirus 1 infection and infectious bovine rhinotracheitis Bovine herpesvirus type 1 infection of bovine bronchial epithelial cells increases neutrophil adhesion and activation Effects in calves of mixed infections with bovine viral diarrhoea virus and several other bovine viruses The medicine and epidemiology of bovine respiratory disease in feedlots Effect of passive immunity on the development of a protective immune response against bovine viral diarrhea virus in calves Defective function of leukocytes from cattle persistently infected with bovine viral diarrhea virus and the influence of recombinant cytokines Effect of concurrent experimentally induce bovine respiratory syncytial virus and bovine viral diarrhoea virus infection on respiratory tract and enteric diseases in calves Distribution of viral antigen and tissue lesions in persistent and acute infection with homologous strain of noncytopathic bovine viral diarrhoea virus Morphological changes and viral distribution in the ileum of colostrum-deprived calves inoculated with noncytopathic bovine viral diarrhea virus genotype-1 Virus distribution and role of thymic macrophages during experimental infection with noncytopathogenic bovine viral diarrhea virus type 1 Depression of bovine monocyte chemotactic responses by bovine viral diarrhea virus Effect of BVD virus infection on alveolar macrophage functions Macrophages and respiratory viruses Noncytopathic strains of bovine viral diarrhoea virus prime bovine bone marrow-derived macrophages for enhanced generation of nitric oxide Cytokine regulation by virus infection: bovine viral diarrhoea virus, a flavivirus, downregulates production of tumor necrosis factor alpha in macrophages in vitro Enhancement of apoptosis via an extrinsic factor, TNF-a, in cells infected with cytopathic bovine viral diarrhea virus Bovine viral diarrhea viruses modulate toll-like receptors, cytokines and co-stimulatory molecules genes expression in bovine peripheral blood monocytes Apoptosis in lymphoid tissues of calves inoculated with non-cytopathic bovine viral diarrhea virus genotype 1: activation of effector caspase-3 and role of macrophages Hepatic immune response in calves during acute subclinical infection with bovine viral diarrhoea virus type 1 Response of proinflammatory and antiinflammatory cytokines in calves with subclinical bovine viral diarrhea challenged with bovine herpesvirus-1 Real-time PCR for simultaneous detection and genotyping of bovine viral diarrhea virus OIE: Infectious bovine rhinotracheitis/infectious pustular vulvovaginitis Virchow's triad revisited: blood constituents Family-Herpesviridae Infection of vascular endothelial cells with herpes simplex virus enhances tissue factor activity and reduces thrombomodulin expression Platelets from thrombocytopenic ponies acutely infected with equine infectious anemia virus are activated in vivo and hypofunctional Enhanced platelet reactivity in cats experimentally infected with feline infectious peritonitis virus Potentiation of platelet responses in vitro by feline infectious peritonitis virus Early platelet aggregation as a cause of thrombocytopenia in classical swine fever Induction of procoagulant activity in virus infected bovine alveolar macrophages and the effect of lipopolysaccharide Comparison of pathologic changes and viral antigen distribution in tissues of calves with and without pre-existing bovine viral diarrhea virus infection following challenge with bovine herpesvirus-1 Monocyte and macrophage heterogeneity Arterial thrombosis associated with granulocyte-macrophage colony-stimulating factor (GM-CSF) administration in breast cancer patients treated with dose-intensive chemotherapy: a report of two cases Immunology of bovine viral diarrhea virus Distinct role and location of the endothelial isoform of nitric oxide synthase in regulating platelet aggregation in males and females in vivo Filovirus-induced endothelial leakage triggered by infected monocytes/ macrophages Increased release of interleukin-1 beta, interleukin-6, and tumor necrosis factoralpha by bronchoalveolar cells lavaged from involved sites in pulmonary tuberculosis Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • By contrast, BHV-1 group calves displayed an early increase of this cytokine associated with peribronchial areas (at 2 dpi; p < 0.007)


id: cord-003506-ztqjo13e
author: Feng, Min
title: A balanced game: chicken macrophage response to ALV-J infection
date: 2019-03-06
extension: .txt
mime: text/plain
words: 5684
sentence: 250
flesch: 44
cache: cache/cord-003506-ztqjo13e.txt
txt: txt/cord-003506-ztqjo13e.txt
summary:
  In this study, RNA-seq analysis platform and gene overexpression verification were employed to analyze chicken MDM gene expression after ALV-J infection. key: cord-003506-ztqjo13e authors: Feng, Min; Xie, Tingting; Li, Yuanfang; Zhang, Nan; Lu, Qiuyuan; Zhou, Yaohong; Shi, Meiqing; Sun, Jingchen; Zhang, Xiquan title: A balanced game: chicken macrophage response to ALV-J infection date: 2019-03-06 journal: Vet Res DOI: 10.1186/s13567-019-0638-y sha: doc_id: 3506 cord_uid: ztqjo13e Avian leukosis virus subgroup J (ALV-J) infection can cause tumors and immunosuppression in infected chickens.


id: cord-332881-mkm4ygh6
author: Kirchhoff, Jana
date: 2014-02-18
extension: .txt
mime: text/plain
words: 6411
sentence: 280
flesch: 46
cache: cache/cord-332881-mkm4ygh6.txt
txt: txt/cord-332881-mkm4ygh6.txt
title:
  Three viruses of the bovine respiratory disease complex apply different strategies to initiate infection

summary:
  Respiratory epithelial cells were also refractory to infection by BRSV. Another culture system for differentiated respiratory epithelial cells are precision-cut lung slices (PCLS), where the epithelial cells are maintained in their original setting.


id: cord-315072-b28yikvj
author: Giotis, Efstathios S.
date: 2016-08-05
extension: .txt
mime: text/plain
words: 5889
sentence: 217
flesch: 42
cache: cache/cord-315072-b28yikvj.txt
txt: txt/cord-315072-b28yikvj.txt
title:
  Chicken interferome: avian interferon-stimulated genes identified by microarray and RNA-seq of primary chick embryo fibroblasts treated with a chicken type I interferon (IFN-α)

summary:
  A virus polymerase host restriction Dynamics of gene expression revealed by comparison of serial analysis of gene expression transcript profiles from yeast grown on two different carbon sources Differential expression in SAGE: accounting for normal between-library variation Involvement of the IRF-1 transcription factor in antiviral responses to interferons Constitutive expression of an ISGF2/IRF1 transgene leads to interferon-independent activation of interferon-inducible genes and resistance to virus infection IFN regulatory factor-1 All things being equal, RNA-seq would seem to be the method of choice for transcriptomic analysis of chicken IFN responses, particularly given its ability to produce high-resolution quantitative and qualitative data.


id: cord-278479-vl296i1b
author: Samuel, Arthur S
title: Experimental infection of hamsters with avian paramyxovirus serotypes 1 to 9
date: 2011-02-23
extension: .txt
mime: text/plain
words: 6325
sentence: 293
flesch: 44
cache: cache/cord-278479-vl296i1b.txt
txt: txt/cord-278479-vl296i1b.txt
summary:
  The isolation of yucaipa-like paramyxoviruses from epizootics of a respiratory disease in turkey poultry farms in Israel Effect of paramyxovirus yucaipa on fertility, hatchability, and poult yield of turkeys A hitherto unreported paramyxovirus of turkeys Isolation of avian paramyxovirus other than Newcastle disease virus from commercial poultry in Great Britain Pathogenecity of PMV-3/Parakeet/Netherland/ 449/75 for chickens Investigation of several selected adjuvants regarding their efficacy and side effects for the production of a vaccine for Isolation of Newcastle disease virus from Phasianidae birds in Hong Kong Comparative study on the pathogenicity and immunogenicity of wild bird isolates of avian paramyxovirus 2, 4, and 6 in chickens Isolation of a new avian paramyxovirus from budgerigar (Melopsittacus undulatus) The virus titers in the supernatants of tissue homogenates from APMV-5 infected hamsters were determined by plaque assay in Vero cells as described above using 10-fold dilution series.


id: cord-295704-3w6hivv8
author: Vidaña, Beatriz
date: 2016-11-08
extension: .txt
mime: text/plain
words: 5800
sentence: 248
flesch: 38
cache: cache/cord-295704-3w6hivv8.txt
txt: txt/cord-295704-3w6hivv8.txt
title:
  Involvement of the different lung compartments in the pathogenesis of pH1N1 influenza virus infection in ferrets

summary:
  NCBI nucleotide database Respiratory epithelial cells in innate immunity to influenza virus infection Critical role of natural killer cells in lung immunopathology during influenza infection in mice Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand Comparison of temporal and spatial dynamics of seasonal H3N2, pandemic H1N1 and highly pathogenic avian influenza H5N1 virus infections in ferrets Severe seasonal influenza in ferrets correlates with reduced interferon and increased IL-6 induction Protection from lethal influenza virus challenge by oral type 1 interferon Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques The pathogenesis of influenza virus infections: the contributions of virus and host factors Activation of the RIG-I pathway during influenza vaccination enhances the germinal center reaction, promotes T follicular helper cell induction, and provides a dose-sparing effect and protective immunity Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus Cytokine response patterns in severe pandemic 2009 H1N1 and seasonal influenza among hospitalized adults CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality Modeling host responses in ferrets during A/California/07/2009 influenza infection Recognition of double-stranded RNA and activation of NF-κB by toll-like receptor 3 Detrimental contribution of the toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signaling Sensing of viral infection and activation of innate immunity by toll-like receptor 3 Role of human toll-like receptors in naturally occurring influenza A infections Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus Toll-like receptor 3 gene polymorphisms and severity of pandemic A/H1N1/2009 influenza in otherwise healthy children Attenuation of the influenza virus sickness behavior in mice deficient in toll-like receptor 3 Does toll-like receptor 3 play a biological role in virus infections


id: cord-308298-5ntdb8yf
author: Mair, Kerstin H
title: Porcine CD8α(dim/-)NKp46(high) NK cells are in a highly activated state
date: 2013-03-01
extension: .txt
mime: text/plain
words: 7673
sentence: 317
flesch: 49
cache: cache/cord-308298-5ntdb8yf.txt
txt: txt/cord-308298-5ntdb8yf.txt
summary:
  Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets Analysis of natural killer cells in TAP2-deficient patients: expression of functional triggering receptors and evidence for the existence of inhibitory receptor(s) that prevent lysis of normal autologous cells Maturation of mouse NK cells is a 4-stage developmental program Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion Roles of the NKG2D immunoreceptor and its ligands Induced recruitment of NK cells to lymph nodes provides IFNγ for T(H)1 priming Natural killer cell accumulation in tumors is dependent on IFN-γ and CXCR3 ligands Intrasplenic trafficking of natural killer cells is redirected by chemokines upon inflammation IFN-γ acts on T cells to induce NK cell mobilization and accumulation in target organs Porcine CD8α dim/-NKp46 high NK cells are in a highly activated state The authors thank Maria Stadler, Katharina Reutner, Sandra Groiß and Sarah Rosenthaler for their technical support. Thus, our data indicates that CD8α dim/-NKp46 high NK cells in the pig are in a highly activated state.


id: cord-287153-jbuuph6w
author: Lund, Morten
date: 2016-10-21
extension: .txt
mime: text/plain
words: 7465
sentence: 340
flesch: 51
cache: cache/cord-287153-jbuuph6w.txt
txt: txt/cord-287153-jbuuph6w.txt
title:
  Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar)

summary:
  Genes were selected based on their correlation with severity of pathological changes in heart induced by SAV infection, as previously reported [41] . Lesions in the pancreas are a hallmark of SAV infection and used diagnostically for separation of PD and HSMI


id: cord-028887-eseo7lyh
author: Li, Chong
title: Exploring heterologous prime-boost vaccination approaches to enhance influenza control in pigs
date: 2020-07-09
extension: .txt
mime: text/plain
words: 7583
sentence: 292
flesch: 48
cache: cache/cord-028887-eseo7lyh.txt
txt: txt/cord-028887-eseo7lyh.txt
summary:
  The genomic evolution of H1 influenza A viruses from swine detected in the United States between Host immune response to influenza a virus infection Development of TH1 CD4 + T cells through IL-12 produced by Listeriainduced macrophages Swine 2012 part II: Reference of swine health and health management in the United States Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine Live attenuated influenza virus vaccine reduces virus shedding of newborn piglets in the presence of maternal antibody A paradigm shift in vaccine production for pandemic influenza The influenza vaccine licensing process Review of influenza A virus in swine worldwide: a call for increased surveillance and research Heterologous Prime-Boost immunisation in Ebola vaccine development, testing and licensure Heterologous prime-boost vaccination Short-and long-term protective efficacy against clade 2.3. When seeder pigs were confirmed IAV positive in their nasal secretions by RRT-PCR, two seeder pigs (one H1 seeder and one H3 seeder) were commingled with the pigs in each room.


id: cord-001714-jfawhnsq
author: Caron, Alexandre
title: Bridge hosts, a missing link for disease ecology in multi-host systems
date: 2015-07-21
extension: .txt
mime: text/plain
words: 7901
sentence: 286
flesch: 40
cache: cache/cord-001714-jfawhnsq.txt
txt: txt/cord-001714-jfawhnsq.txt
summary:
  Bridge hosts provide a link through which pathogens can be transmitted from maintenance host populations or communities to receptive populations that people want to protect (i.e., target hosts). Here we focus on the definition of bridge hosts and their epidemiological consequences.


id: cord-266199-smlq11y9
author: Dhakal, Santosh
title: Nanoparticle-based vaccine development and evaluation against viral infections in pigs
date: 2019-11-06
extension: .txt
mime: text/plain
words: 7654
sentence: 319
flesch: 32
cache: cache/cord-266199-smlq11y9.txt
txt: txt/cord-266199-smlq11y9.txt
summary:
  potential and limitations Respiratory nanoparticle-based vaccines and challenges associated with animal models and translation Chitosan nanoparticles act as an adjuvant to promote both Th1 and Th2 immune responses induced by ovalbumin in mice Poly(anhydride) nanoparticles act as active Th1 adjuvants through Toll-like receptor exploitation Liposome-based adjuvants for subunit vaccines: formulation strategies for subunit antigens and immunostimulators Vaccine delivery using nanoparticles Potent antigen-specific immune responses stimulated by codelivery of CpG ODN and antigens in degradable microparticles Enhancement of immune responses by co-delivery of a CpG oligodeoxynucleotide and tetanus toxoid in biodegradable nanospheres Co-delivery of cancer-associated antigen and Toll-like receptor 4 ligand in PLGA nanoparticles induces potent CD8+ T cell-mediated anti-tumor immunity M-cell targeted biodegradable PLGA nanoparticles for oral immunization against hepatitis B Dendritic cell targeted chitosan nanoparticles for nasal DNA immunization against SARS CoV nucleocapsid protein Rapid endo-lysosomal escape of poly(dl-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery Enhanced and prolonged crosspresentation following endosomal escape of exogenous antigens encapsulated in biodegradable nanoparticles Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease Entrapment of H1N1 influenza virus derived conserved peptides in PLGA nanoparticles enhances T cell response and vaccine efficacy in pigs Biodegradable nanoparticle delivery of inactivated swine influenza virus vaccine provides heterologous cell-mediated immune response in pigs Induction of potent antigen-specific cytotoxic T cell response by PLGA-nanoparticles containing antigen and TLR agonist Polyanhydride nanovaccine against swine influenza virus in pigs Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development Virus-like particle engineering: from rational design to versatile applications Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages Major findings and recent advances in virus-like particle (VLP)-based vaccines Development of a porcine reproductive and respiratory Research efforts are ongoing to develop porcine viral vaccines using NPs-based technologies.


id: cord-275443-9ib77yws
author: Xie, Xing
title: Monoclonal antibody specific to HA2 glycopeptide protects mice from H3N2 influenza virus infection
date: 2015-03-19
extension: .txt
mime: text/plain
words: 8291
sentence: 325
flesch: 52
cache: cache/cord-275443-9ib77yws.txt
txt: txt/cord-275443-9ib77yws.txt
summary:
  Among them, vaccination is an important method to prevent and control influenza virus infection Preventive vaccination is historically the primary measure to control influenza virus infection, but it has some limitations


id: cord-310194-f5jtufja
author: Benedictus, Lindert
date: 2014-12-17
extension: .txt
mime: text/plain
words: 8625
sentence: 339
flesch: 52
cache: cache/cord-310194-f5jtufja.txt
txt: txt/cord-310194-f5jtufja.txt
title:
  Bovine Neonatal Pancytopenia is a heritable trait of the dam rather than the calf and correlates with the magnitude of vaccine induced maternal alloantibodies not the MHC haplotype

summary:
  The difference in protein sequence between the extracellular parts of the MDBK and dam MHC class I alleles was 13.6% (0.35%) for vaccinated non-BNP dams and 12.9% (0.40%) for BNP dams, with a P-value of 0.266 this was not significantly different between both groups (Additional file 4). Alloantibodies were detected in both vaccinated BNP and non-BNP dams and we found no differences in alloantibody characteristics between these groups, but alloantibody levels were significantly higher in BNP dams.


id: cord-010835-nnorilo6
author: Lu, Mingmin
date: 2020-05-13
extension: .txt
mime: text/plain
words: 7495
sentence: 276
flesch: 39
cache: cache/cord-010835-nnorilo6.txt
txt: txt/cord-010835-nnorilo6.txt
title:
  Proteomic analysis revealed T cell hyporesponsiveness induced by Haemonchus contortus excretory and secretory proteins

summary:
  Additionally, among the GO terms of T cell binding proteins, cellular component terms were allocated to the extracellular space (n = 4) and integral component of membrane (n = 3) subcategories. As the regulators and the regulated at the host-parasite interface, T cells play pivotal roles against GI nematode infections.


id: cord-259296-qsaewje2
author: Wang, Pengcheng
title: Tomatidine inhibits porcine epidemic diarrhea virus replication by targeting 3CL protease
date: 2020-11-11
extension: .txt
mime: text/plain
words: 8207
sentence: 407
flesch: 51
cache: cache/cord-259296-qsaewje2.txt
txt: txt/cord-259296-qsaewje2.txt
summary:
  D Docked conformations of tomatidine with PEDV 3CLpro or inactive 3CLpro. To verify the binding of 3CLpro and tomatidine, PEDV 3CLpro fused with His tag was expressed in soluble form using an E. coli expression system ( Figure 5A(i) ).


id: cord-312695-1uw8xcxw
author: Sugiarto, Sarah
date: 2016-08-05
extension: .txt
mime: text/plain
words: 8634
sentence: 316
flesch: 47
cache: cache/cord-312695-1uw8xcxw.txt
txt: txt/cord-312695-1uw8xcxw.txt
title:
  Passive immunization does not provide protection against experimental infection with Mycoplasma haemofelis

summary:
  After passive immunization and subsequent infection, group A cats showed slightly but significantly higher DnaK ELISA OD 415 values at days 3, 7 and 14 pi compared with the OD 415 values of cats in group B (p MWU < 0.05; Figure 2C ). There was no significant difference in the time of seroconversion (OD 415 > 0.33) between the two groups; cats in both groups, A and B, seroconverted between days 21 and 49 pi, with the exception of cat JHW3 (group B), which did not develop anti-Mhf DnaK antibodies throughout the study ( Figure 2B ).


id: cord-033692-txfuuu7d
author: Lim, Byeonghwi
date: 2020-10-13
extension: .txt
mime: text/plain
words: 7941
sentence: 286
flesch: 38
cache: cache/cord-033692-txfuuu7d.txt
txt: txt/cord-033692-txfuuu7d.txt
title:
  Integrated time-serial transcriptome networks reveal common innate and tissue-specific adaptive immune responses to PRRSV infection

summary:
  The remaining pigs were humanely euthanised without virus infection as an uninfected control (0 dpi) group. Dynamic changes in these significant gene subsets at 3 dpi may represent biological signals associated with general and early immunological mechanisms in response to virus infection.


id: cord-341305-zf97tcwe
author: Ge, Shikun
date: 2020-09-03
extension: .txt
mime: text/plain
words: 3696
sentence: 130
flesch: 41
cache: cache/cord-341305-zf97tcwe.txt
txt: txt/cord-341305-zf97tcwe.txt
title:
  Canine Parvovirus is diagnosed and neutralized by chicken IgY-scFv generated against the virus capsid protein

summary:
  scFv bound in a dose-dependent manner to the soluble VP2 ( Figure 5 ). The CRFK cells expressing scFv showed a small amount of cytopathic effect (CPE) after CPV infection; the cells without scFv expression were significantly broken away from the bottom wall, became round, and some cells even broke up ( Figure 7D ).


id: cord-331001-7pyuy1os
author: Miyazaki, Ayako
date: 2011-11-09
extension: .txt
mime: text/plain
words: 4273
sentence: 195
flesch: 54
cache: cache/cord-331001-7pyuy1os.txt
txt: txt/cord-331001-7pyuy1os.txt
title:
  Genetic diversity of group A rotaviruses associated with repeated outbreaks of diarrhea in a farrow-to-finish farm: identification of a porcine rotavirus strain bearing a novel VP7 genotype, G26

summary:
  Based on the sequence and phylogenic analysis of GAR strains detected among the four outbreaks, at least five combinations of G and P genotypes (G/P combinations) were identified: G9P Sequence analysis of the detected GARs revealed that such genetic diversity could have resulted not only from the introduction of new GAR strains, but also from gene reassortment between GAR strains within the farm.


id: cord-324950-ux7shvji
author: Saade, Georges
title: Coinfections and their molecular consequences in the porcine respiratory tract
date: 2020-06-16
extension: .txt
mime: text/plain
words: 11756
sentence: 443
flesch: 32
cache: cache/cord-324950-ux7shvji.txt
txt: txt/cord-324950-ux7shvji.txt
summary:
  Microorganisms associated with pneumonia in slaughter weight swine Retrospective analysis of etiologic agents associated with respiratory diseases in pigs Infectious agents associated with respiratory diseases in 125 farrow-to-finish pig herds: a cross-sectional study Transcriptome analysis of porcine thymus following porcine cytomegalovirus infection Interaction between Mycoplasma hyopneumoniae and swine influenza virus Epidemiological characteristics of pulmonary pneumocystosis and concurrent infections in pigs in Jeju Island Longitudinal study of respiratory infection patterns of breeding sows in five farrow-to-finish herds Bacterial pathogens associated with lung lesions in slaughter pigs from 125 herds Reorganization and expansion of the nidoviral family Arteriviridae Porcine alveolar macrophage-like cells are pro-inflammatory pulmonary intravascular macrophages that produce large titers of porcine reproductive and respiratory syndrome virus Porcine Reproductive and Respiratory Syndrome Virus (PRRSV): pathogenesis and interaction with the immune system Infection of monocytes with European porcine reproductive and respiratory syndrome virus (PRRSV-1) strain Lena is significantly enhanced by dexamethasone and IL-10 Phenotypic and functional modulation of bone marrow-derived dendritic cells by porcine reproductive and respiratory syndrome virus Porcine reproductive and respiratory syndrome virus productively infects monocyte-derived dendritic cells and compromises their antigen-presenting ability Porcine Reproductive and Respiratory Syndrome Virus Type 1.3 Lena triggers conventional dendritic cells 1 activation and T helper 1 immune response without infecting dendritic cells Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny PRRS virus receptors and their role for pathogenesis Molecular cloning of porcine Siglec-3, Siglec-5 and Siglec-10, and identification of Siglec-10 as an alternative receptor for porcine reproductive and respiratory syndrome virus (PRRSV) Involvement of sialoadhesin in entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus Replacement of porcine CD163 scavenger receptor cysteine-rich domain 5 with a CD163-Like homolog confers resistance of pigs to genotype 1 but not genotype 2 porcine reproductive and respiratory syndrome virus Direct interaction between CD163 N-terminal domain and MYH9 C-terminal domain contributes to porcine reproductive and respiratory syndrome virus internalization by permissive cells Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: correlations with pathogenicity Increased production of proinflammatory cytokines following infection with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae Porcine reproductive and respiratory syndrome virus field isolates differ in in vitro interferon phenotypes Cytokine profiles and phenotype regulation of antigen presenting cells by genotype-I porcine reproductive and respiratory syndrome virus isolates Strain-dependent porcine circovirus type 2 (PCV2) entry and replication in T-lymphoblasts Cell tropism and entry of porcine circovirus 2 Porcine circovirus diseases Characteristics of porcine circovirus-2 replication in lymphoid organs of pigs inoculated in late gestation or postnatally and possible relation to clinical and pathological outcome of infection Porcine circovirus type 2 (PCV2) distribution and replication in tissues and immune cells in early infected pigs Porcine circovirus type 2 displays pluripotency in cell targeting Dendritic cells harbor infectious porcine circovirus type 2 in the absence of apparent cell modulation or replication of the virus Association of lymphopenia with porcine circovirus type 2 induced postweaning multisystemic wasting syndrome (PMWS) Cytokine profiles of peripheral blood mononuclear cells from pigs with postweaning multisystemic wasting syndrome in response to mitogen, superantigen or recall viral antigens Distribution and characterization of IL-10-secreting cells in lymphoid tissues of PCV2-infected pigs Porcine circovirus type 2 (PCV2) viral components immunomodulate recall antigen responses Subset-dependent modulation of dendritic cell activity by circovirus type 2 Review: influenza virus in pigs Influenza The impact of animal age, bacterial coinfection, and isolate pathogenicity on the shedding of porcine reproductive and respiratory syndrome virus in aerosols from experimentally infected pigs Actinobacillus pleuropneumoniae possesses an antiviral activity against porcine reproductive and respiratory syndrome virus Enriched housing reduces disease susceptibility to co-infection with porcine reproductive and respiratory virus (PRRSV) and Actinobacillus pleuropneumoniae (A. pleuropneumoniae) in young pigs Dual infections of PRRSV/influenza or PRRSV/Actinobacillus pleuropneumoniae in the respiratory tract Polybacterial human disease: the ills of social networking How viral and intracellular bacterial pathogens reprogram the metabolism of host cells to allow their intracellular replication Intra-species and inter-species differences in cytokine production by porcine antigen-presenting cells stimulated by Mycoplasma hyopneumoniae Viral interference and interferon Type I interferons in infectious disease Type III interferons in viral infection and antiviral immunity The roles of type I interferon in bacterial infection A role for IFN-alpha beta in virus infection-induced sensitization to endotoxin Influenza trains the host for enhanced susceptibility to secondary bacterial infection Type I interferon induction during influenza virus infection increases susceptibility to secondary Streptococcus pneumoniae infection by negative regulation of γδ T cells Intrinsic interference: non-interferon mediated viral interference Virus-bacteria interactions: implications and potential for the applied and agricultural sciences The antiviral and antitumor effects of defective interfering particles/genomes and their mechanisms RNAi, a new therapeutic strategy against viral infection Non-specific dsRNA-mediated antiviral response in the honey bee Roles of nonstructural polyproteins and cleavage products in regulating Sindbis virus RNA replication and transcription Superinfection prevents recombination of the alphaherpesvirus bovine herpesvirus 1 Classical swine fever virus vs. classical swine fever virus: the superinfection exclusion phenomenon in experimentally infected wild boar Porcine reproductive and respiratory syndrome virus (PRRSV) influences infection dynamics of porcine circovirus type 2 (PCV2) subtypes PCV2a and PCV2b by prolonging PCV2 viremia and shedding Microbiome associations in pigs with the best and worst clinical outcomes following co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2)


id: cord-354114-frdsct44
author: Vogel, Liesbeth
title: Pathogenic characteristics of persistent feline enteric coronavirus infection in cats
date: 2010-07-23
extension: .txt
mime: text/plain
words: 5344
sentence: 214
flesch: 48
cache: cache/cord-354114-frdsct44.txt
txt: txt/cord-354114-frdsct44.txt
summary:
  A study of naturally occurring feline coronavirus infections in kittens Use of a reverse-transcriptase polymerase chain reaction for monitoring the shedding of feline coronavirus by healthy cats Rapid and simple method for purification of nucleic acids Feline infectious peritonitis: insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3c gene Replication of feline coronaviruses in peripheral blood monocytes Patterns of feline coronavirus infection and fecal shedding from cats in multiple-cat environments Detection of feline coronaviruses by culture and reverse transcriptase-polymerase chain reaction of blood samples from healthy cats and cats with clinical feline infectious peritonitis Detection of FCoV quasispecies using denaturing gradient gel electrophoresis One-tube fluorogenic reverse transcription-polymerase chain reaction for the quantitation of feline coronaviruses Live, attenuated coronavirus vaccines through the directed deletion of group-specific genes provide protection against feline infectious peritonitis Feline coronaviruses: a tale of two-faced types Detection of feline coronavirus RNA in feces, tissues, and body fluids of naturally infected cats by reverse transcriptase PCR Persistence and evolution of feline coronavirus in a closed cat-breeding colony Elimination of feline coronavirus infection from a large experimental specific pathogen-free cat breeding colony by serologic testing and isolation Characterization of monoclonal antibodies against feline infectious peritonitis virus type II and antigenic relationship between feline, porcine, and canine coronaviruses The prevalence of types I and II feline coronavirus infections in cats Natural FCoV infection: cats with FIP exhibit significantly higher viral loads than healthy infected cats Natural feline coronavirus infection: Differences in cytokine patterns in association with the outcome of infection Sites of feline coronavirus persistence in healthy cats Feline immunodeficiency virus in Switzerland: clinical aspects and epidemiology in comparison with feline leukemia virus and coronaviruses High viral loads despite absence of clinical and pathological findings in cats experimentally infected with feline coronavirus (FCoV) type I and in naturally FCoV-infected cats Infection studies in kittens, using feline infectious peritonitis virus propagated in cell culture An enteric coronavirus infection of cats and its relationship to feline infectious peritonitis Pathogenesis of feline enteric coronavirus infection A review of feline infectious peritonitis virus infection Two related strains of feline infectious peritonitis virus isolated from immunocompromised cats infected with a feline enteric coronavirus Acquisition of macrophage tropism during the pathogenesis of feline infectious peritonitis is determined by mutations in the feline coronavirus spike protein A mRNA PCR for the diagnosis of feline infectious peritonitis Intrinsic resistance of feline peritoneal macrophages to coronavirus infection correlates with in vivo virulence Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses Acknowledgements. The presence of virus in blood was tested by performing a real-time RT-PCR on whole EDTA blood of FECV UCD infected cats.


id: cord-344845-52rehsd5
author: Opriessnig, Tanja
date: 2017-10-26
extension: .txt
mime: text/plain
words: 5163
sentence: 217
flesch: 56
cache: cache/cord-344845-52rehsd5.txt
txt: txt/cord-344845-52rehsd5.txt
title:
  Evaluation of the efficacy of a commercial inactivated genogroup 2b-based porcine epidemic diarrhea virus (PEDV) vaccine and experimental live genogroup 1b exposure against 2b challenge

summary:
  Pigs orally vaccinated with an experimental heterologous G1b live vaccine had a tendency for a shortened viral shedding duration; whereas pigs vaccinated intramuscularly with an experimental heterologous G1b live vaccine were not protected. In this study growing pigs were used to test and compare the efficacy of live or inactivated vaccines to protect pigs against challenge with a highly virulent G2b


id: cord-334968-gonx5taq
author: Pignatelli, Jaime
date: 2013-12-23
extension: .txt
mime: text/plain
words: 6807
sentence: 250
flesch: 47
cache: cache/cord-334968-gonx5taq.txt
txt: txt/cord-334968-gonx5taq.txt
title:
  Lineage specific antigenic differences in porcine torovirus hemagglutinin-esterase (PToV-HE) protein

summary:
  In a previous study, PToV virus strains with HE proteins from the two lineages were found coexisting in a pig herd, and they were even obtained from the same animal at two consecutive sampling time points. The 3D structure and sialic acid preference of PToV-(strain Markelo) and BToV-(strain Breda) HE proteins have been solved [12] .


id: cord-351881-qea4b0i5
author: Eck, Melanie
date: 2016-02-19
extension: .txt
mime: text/plain
words: 6306
sentence: 264
flesch: 44
cache: cache/cord-351881-qea4b0i5.txt
txt: txt/cord-351881-qea4b0i5.txt
title:
  Virus replicon particles expressing porcine reproductive and respiratory syndrome virus proteins elicit immune priming but do not confer protection from viremia in pigs

summary:
  In order to address the question whether PRRSV structural proteins are immunogenic at all when expressed by VSV VRP in pigs, a vector expressing PRRSV N protein was included in one vaccination trial. For the detection of PRRSV proteins, monoclonal antibody (mAb) 13E2 directed against PRRSV N, and mAb VII2D directed against amino acids 73-84 of PRRSV GP3 were kindly provided by Hans Nauwynck (University Ghent, Belgium).


id: cord-350626-ov9fy10b
author: Nazki, Salik
date: 2020-05-13
extension: .txt
mime: text/plain
words: 9925
sentence: 325
flesch: 41
cache: cache/cord-350626-ov9fy10b.txt
txt: txt/cord-350626-ov9fy10b.txt
title:
  Evaluation of local and systemic immune responses in pigs experimentally challenged with porcine reproductive and respiratory syndrome virus

summary:
  T cells, in turn, play a critical role in the development of anti-PRRSV immunity due to their cytotoxic effector functions in clearing infected cells from the body and developing and regulating antigen-specific immune responses [12] . Delayed induction of Th1, Th17 and CTL responses was observed in the PBMC of the infected pigs after 21 dpc, when most of the virus had been cleared from the blood, whereas in BLN, the virus persists for a longer period, which leads to early and sustained (> 35 dpc) induction of T cell responses.


id: cord-316908-8ti75mru
author: Wei, Xiaona
date: 2020-02-10
extension: .txt
mime: text/plain
words: 10526
sentence: 439
flesch: 54
cache: cache/cord-316908-8ti75mru.txt
txt: txt/cord-316908-8ti75mru.txt
title:
  PEDV enters cells through clathrin-, caveolae-, and lipid raft-mediated endocytosis and traffics via the endo-/lysosome pathway

summary:
  Considering that CoVs take advantage of different pathways to enter cells, whether different subtypes of PEDV invade cells by different ways and whether PEDV enter different types of cells through different ways remains to be determined. These differences between GDS01 and GDS09 strains may be due to the difference of S gene especially the S1 region of S gene (homology was about 92%), which is responsible for cell entry and membrane fusion by binding with receptor.


id: cord-343421-k1dqe4lk
author: Hoelzer, Karin
date: 2018-07-31
extension: .txt
mime: text/plain
words: 9645
sentence: 367
flesch: 30
cache: cache/cord-343421-k1dqe4lk.txt
txt: txt/cord-343421-k1dqe4lk.txt
title:
  Vaccines as alternatives to antibiotics for food producing animals. Part 2: new approaches and potential solutions

summary:
  Underneath the mucus layer, a single layer of intestinal epithelial cells prevents uncontrolled access of the luminal content to the underlying intestinal tissues, further restricting uptake of oral vaccine antigens. This often results in a low immunogenicity of oral vaccines and requires innovative strategies to deliver the vaccine antigens to the intestinal immune system as well as the inclusion of adjuvants that promote innate and adaptive immunity [5] .


# ent

id: cord-310194-f5jtufja
sid: 316
eid: 1
type: PERSON
entity:
  gehäuftes auftreten von hämorrhagischer diathese infolge knochenmarkschädigung bei jungen kälbern calf-level


