        item: #1 of 39
          id: cord-003246-3ajfb18m
      author: Liang, Zhenli
       title: Histopathological Features and Viral Antigen Distribution in the Lung of Fatal Patients with Enterovirus 71 Infection
        date: 2018-04-19
       words: 2197
      flesch: 38
     summary: G-L Pathological changes of lung tissues in fatal children with EV71 infection (HE staining). These data suggested that EV71 could infect lung tissues, with respiratory tract as one of the portals of invasion.
    keywords: alveolar; cells; ev71; lung; tissues
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        item: #2 of 39
          id: cord-005340-o7tkxs3s
      author: Fu, Xinliang
       title: Import of Rift Valley fever to China: a potential new threat?
        date: 2016-10-27
       words: 1220
      flesch: 51
     summary: Subsequently, there have been several RVF outbreaks with significant impact on human health in eastern Africa and the Arabian Peninsula (Meegan, 1979; CDC, 1998; Shoemaker et al., 2002; Woods et al., 2002) (http://www.who.int/csr/ don/2007_05_09/en/). The RVF outbreak that occurred in Saudi Arabia and Yemen in 2000 resulted in 2171 infections and 245 deaths (Shoemaker et al., 2002) , and this outbreak is reported to have been caused by the same strain of the RVF virus that caused the outbreak in Kenya in 1997-1998 (Shoemaker et al., 2002) .
    keywords: china; rvf
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        item: #3 of 39
          id: cord-005372-7x8ro8p2
      author: Jiménez, Luisa Fernanda Mancipe
       title: Association of swine influenza H1N1 pandemic virus (SIV-H1N1p) with porcine respiratory disease complex in sows from commercial pig farms in Colombia
        date: 2014-08-08
       words: 3926
      flesch: 40
     summary: Analysis was completed using logistic regression to de-termine the likelihood of increase in PRDC disease presentation in SIV-H1N1p-positive farms. The main goal of the present study was to conduct a systematic analysis of swine influenza virus infection and determine its role in PRDC presentation in the major swine-producing areas of Colombia.
    keywords: disease; et al; farms; h1n1p; prdc; presentation; siv; swine; virus
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        item: #4 of 39
          id: cord-005397-i7x50taa
      author: Wang, Wen-juan
       title: Preparation and identification of anti-rabies virus monoclonal antibodies
        date: 2012-06-09
       words: 1429
      flesch: 40
     summary: Since then, rabies virus monoclonal antibody (McAb) technology has been more and more widely used in basic research, and the testing and diagnosis of rabies. [11] reported the preparation of rabies virus monoclonal antibodies.
    keywords: antibodies; monoclonal; rabies; virus
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        item: #5 of 39
          id: cord-006752-fmdvwnbw
      author: Mao, Huawei
       title: Conservation of T cell epitopes between seasonal influenza viruses and the novel influenza A H7N9 virus
        date: 2014-06-17
       words: 2673
      flesch: 48
     summary: Although many of the hospitalized patients with H7N9 virus infection had severe illness, several cases were identifi ed via infl uenza-like illness surveillance network and presented with mild clinical phenotype, even did not require hospitalization. The conservation of these seasonal infl uenza viral epitopes in avian infl uenza viruses was further analyzed.
    keywords: cell; epitopes; h7n9; infl; uenza; virus
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        item: #6 of 39
          id: cord-014920-mmykzj9w
      author: Wang, Shi-qun
       title: Biological effects of HBV X protein on hepatocellular carcinogenesis in association with cellular factors
        date: 2008-05-10
       words: 1018
      flesch: 3
     summary: Microvasc Res COX-2 inhibitors--IBC conference Nitric oxide synthase expression and activity in the tight-skin mouse model of fibrosis Survival and apoptosis: a dysregulated balance in liver cancer The upregulation of expressed proteins in HepG2 cells transfected by the recombinant plasmid-containing HBx gene Putative tumor suppressor YueF affects the functions of hepatitis B virus X protein in hepatoma cell apoptosis and p53 expression Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression Spike protein of SARS-CoV stimulates cyclooxygenase-2 expression via both calcium-dependent and calcium-independent protein kinase C pathways Hepatitis B virus replication is associated with an HBxdependent mitochondrion-regulated increase in cytosolic calcium levels Cyclooxygenase-2 expression inhibits trophic withdrawal apoptosis in nerve growth factor-differentiated PC12 cells Cyclooxygenase 2 expression in rat corneas after ethanol exposure Hepatitis B virus X protein overcomes oncogenic RASinduced senescence in human immortalized cells Borna disease virus P protein inhibits nitric oxide synthase gene expression in astrocytes Cyclooxygenase 2 expression in vessels and nerves in reversal reaction leprosy Hepatitis B virus biology Cyclooxygenase regulates angiogenesis induced by colon cancer cells Functional switch of viral protein HBx on cell apoptosis, transformation, and tumorigenesis in association with oncoprotein Ras Host cyclooxygenase-2 modulates carcinoma growth Hepatic tumor necrosis factor signaling and nuclear factor-kappaB: effects on liver homeostasis and beyond Nucleocapsid protein of SARS-CoV activates the expression of cyclooxygenase-2 by binding directly to regulatory elements for nuclear factor-kappa B and CCAAT/enhancer binding protein Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogenactivated protein/extracellular signal-regulated kinasemitogen-activated protein pathway Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease Hepsin The effects of HBx are mediated by interaction with cell proteins and activation of cell signaling pathways.
    keywords: protein; virus
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        item: #7 of 39
          id: cord-014923-gfiqjgxg
      author: Zhang, Yi
       title: The functional motif of SARS-CoV S protein involved in the interaction with ACE2
        date: 2009-09-16
       words: 1861
      flesch: 52
     summary: Our data showed that the aa 388~396 of S1 protein was essential to the interaction between S protein and ACE2. The results in these two experiments are different suggesting that denaturing of various truncated S1 proteins in SDS-PAGE in the first experiment disrupt the conformation of S1 proteins.
    keywords: ace2; protein; sars
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        item: #8 of 39
          id: cord-014927-g4r7j8hk
      author: Shao, Yi-ming
       title: AIDS research and its role in China’s AIDS prevention and control policies
        date: 2008-01-13
       words: 668
      flesch: 44
     summary: By the mid 1990s, the HIV/AIDS epidemic was scaled-up by both further spread of drug abuse in other regions and blood contamination in the illegal plasma collection activities in central China (13, 14) . key: cord-014927-g4r7j8hk authors: Shao, Yi-ming title: AIDS research and its role in China’s AIDS prevention and control policies date: 2008-01-13 journal:
    keywords: aids; china; hiv
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        item: #9 of 39
          id: cord-014932-web2tdef
      author: Li, Jian-qiang
       title: Cloning the structure genes and expression the N gene of porcine epidemic diarrhea virus DX
        date: 2009-05-28
       words: 1203
      flesch: 48
     summary: The production of recombinant infectious DI-particles of a Sequence of the spike protein of the Porcine epidemic diarrhea virus Characterization of the structural proteins of porcine epidemic diarrhea virus, strain CV777 Cloning and sequence analysis of the M gene of Porcine epidemic diarrhea virus LJB/03 Cloning and sequence analysis of the N gene of porcine epidemic diarrhea virus LJB/03 Serologic study of the occurrence of epizootic viral diarrhea in swine in Switzerland Cloning and sequence analysis of the Korean strain of spike gene of Porcine epidemic diarrhea virus and expression of its neutralizing epitope in plants Cloning and Sequence Analysis of the Nucleocapsid Gene of Porcine Epidemic Diarrhea Virus Chinju99 The molecular biology of coronaviruses Erhebungen uber porcine coronaviren in osterreich II porcine epidemic diarrhea virus (PEDV) der schweine Complete Genome Sequence of Transmissible Gastroenteritis Coronavirus PUR46-MAD Clone and Evolution of the Purdue Virus Cluster Isolation of porcine epidemic diarrhea virus in porcine cell cultures and experimental infection of pigs of different ages A novel internal open reading frame product expressed from a polycistronic of porcine edpidemic diarrhea virus may not contribute to virus attenuation Disease of Swine A cell culture vaccine against bovine ephemeral fever Cloning and sequence analysis of the spike gene of Porcine epidemic diarrhea virus Chiju99 TheDX N protein contained 37 Arginine, 33 lysine and 36 Serine.
    keywords: diarrhea; porcine; protein; virus
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        item: #10 of 39
          id: cord-014938-7evmiuv5
      author: Wei-ming, Yan
       title: Expression of prothrombinase/fibroleukin gene fg12 in lung impairment in a murine severe acute respiratory syndrome model
        date: 2008-01-13
       words: 1095
      flesch: 28
     summary: Clinical features and short-term outcomes of 144 patients with SARS in Toronto Area SARS-associated viral hepatitis caused by a novel coronavirus: report of three cases Detection of severe acute respiratory syndrome-associated coronavirus in pneumocytes of the lung Fuliminant hepatic failure hepatitis virus strain 3 infection: tissue-specific expression of a novel fgl2 prothrombinase The clinical pathology of severe acute respiratory syndrome (SARS): a report from China Identification of a novel coronavirus in patients with severe acute respiratory syndrome Aetiology: Koch's postulates fulfilled for SARS virus Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore Discovery of novel human and animal cells infected by the severe acute respiratory syndrome coronavirus by replication-specific multiplex reverse transcription-PCR defense following severe acute respiratory syndromecoronavirus (SARS-CoV) pulmonary infection of mice A novel coronavirus associated with severe acute respiratory syndrome Mouse hepatitis virus 3-thymic cell interactions correlating with viral pathogenicity A major outbreak of severe acute respiratory syndrome in Hong Kong Molecular and functional analysis of the human prothrombinase gene (HFGL2) and its role in viral hepatitis Identification of an epitope of SARS-coronavirus nucleocapsid protein Acute and chronic changes in the microcirculation of the liver in inbred strains of mice following infection with mouse hepatitis virus type 3 The genome sequence of SARS-associated coronavirus The fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection A method to establish a murine model of fulminant viral hepatitis Role of Fgl2 Prothrombinase/ Fibroleukin in Experimental and Human Allograft Rejection The aetiology of SARS: in lung impairment in Severe acute respiratory syndrome (SARS), a murine SARS model induced by Murine hepatitis virus strain 3 (MHV-3) through trachea was established.
    keywords: coronavirus; mice; sars; syndrome
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        item: #11 of 39
          id: cord-014946-l3vwb2v7
      author: Tian, Hong
       title: Genetic variation analyses of nsp2 gene of PRRSV in Ningxia Hui Autonomous Region of China
        date: 2009-05-28
       words: 635
      flesch: 48
     summary: Ningxia and ch-1a was 60.3%-79.9% in nucleotide sequence, and homology between Ningxia and the common SD strain was 80.3%-98.8% in nucleotide sequence. Sequence analysis indicated that homology between the Ningxia strain and ch-1a was 60.3%–79.9% in the nucleotide sequence, and homology between the NX strains and SD strains was 80.3%–98.8% in the nucleotide sequence.
    keywords: sequence
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        item: #12 of 39
          id: cord-025181-eg108wcd
      author: Zheng, Zhihang
       title: Establishment of Murine Infection Models with Biological Clones of Dengue Viruses Derived from a Single Clinical Viral Isolate
        date: 2020-05-25
       words: 5990
      flesch: 50
     summary: Our research here provides two kinds of dengue virus infection mouse models, which reproduce both severe and self-limited manifestations of human diseases, expanding the current choice of dengue viral infection small animal models. As type I/II interferon deficient mice are more susceptible to dengue virus infection, we determined the in vivo infectivity of these two viruses in type I and type II IFN receptors double knock-out AG6 mice.
    keywords: cells; dengue; denv-2; ifn; infection; mice; pfu; type; viral; virus; viruses
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        item: #13 of 39
          id: cord-025232-5itrsfmk
      author: Yan, Yuqian
       title: Construction and Characterization of a Novel Recombinant Attenuated and Replication-Deficient Candidate Human Adenovirus Type 3 Vaccine: “Adenovirus Vaccine Within an Adenovirus Vector”
        date: 2020-05-26
       words: 5684
      flesch: 36
     summary: A community-derived outbreak of adenovirus type 3 in children in Taiwan between Molecular identification and epidemiological features of human adenoviruses associated with acute respiratory infections in hospitalized children in Southern China Comparative genomic analysis of re-emergent human adenovirus type 55 pathogens associated with adult severe communityacquired pneumonia reveals conserved genomes and capsid proteins Adenoviral infections in Singapore: should new antiviral therapies and vaccines be adopted? Analysis of 15 adenovirus hexon proteins reveals the location and structure of seven hypervariable regions containing serotype-specific residues Generation and characterization of a novel candidate gene therapy and vaccination vector based on human species D adenovirus type 56 Mortime P (eds) Principles and practice of clinical virology, 6th edn Hexon and fiber of adenovirus type 14 and 55 are major targets of neutralizing antibody but only fiber-specific antibody contributes to cross-neutralizing activity Molecular epidemiology of adenovirus type 3 detected from 1994 to 2006 in Hyogo Prefecture Immune response to recombinant capsid proteins of adenovirus in humans: antifiber and anti-penton base antibodies have a synergistic effect on neutralizing activity Gene therapy clinical trials worldwide to 2017: an update A recombinant adenovirusbased vector elicits a specific humoral immune response against the V3 loop of HIV-1 gp120 in mice through the 'Antigen Capsid-Incorporation' strategy Identification and typing of respiratory adenoviruses in Guangzhou, Southern China using a rapid and simple method A primary school outbreak of pharyngoconjunctival fever caused by adenovirus type 3 Novel replicationincompetent vector derived from adenovirus type 11 (Ad11) for vaccination and gene therapy: low seroprevalence and non-crossreactivity with Ad5 Household transmission of human adenovirus type 55 in case of fatal acute respiratory disease Emergent US adenovirus 3 strains associated with an epidemic and serious disease Comprehensive serotyping and epidemiology of human adenovirus isolated from the respiratory tract of Korean children over 17 consecutive years Epidemiology, clinical presentation and respiratory sequelae of adenovirus pneumonia in children in Kuala Lumpur Molecular epidemiology and clinical features of adenovirus infection in Taiwanese children Adenovirus infections in immunocompetent and immunocompromised patients Gene therapy progress and prospects cancer: oncolytic viruses Detection and molecular characterization of human adenovirus infections among hospitalized children with acute diarrhea in Safety and immunogenicity of novel adenovirus type 26-and modified vaccinia ankara-vectored Ebola vaccines: a randomized clinical trial Rapid construction of a replication-competent infectious clone of human adenovirus type 14 by gibson assembly Delivery of a foot-and-mouth disease virus empty capsid subunit antigen with nonstructural protein 2B improves protection of swine Adenoviruses and acute respiratory infections in children living in an equatorial area of Brazil Oral administration of an adenovirus vector encoding both an avian influenza A hemagglutinin and a TLR3 ligand induces antigen specific granzyme B and IFN-gamma T cell responses in humans Adenovirus assay by the fluorescent cell-counting procedure Structure-based identification of a major neutralizing site in an adenovirus hexon Dramatic decline of respiratory illness among US military recruits after the renewed use of adenovirus vaccines Gene therapy: the first approved gene-based medicines, molecular mechanisms and clinical indications Vaccine-preventable adenoviral respiratory illness in US military recruits Type-specific epitope locations revealed by X-ray crystallographic study of adenovirus type 5 hexon Structural and phylogenetic analysis of adenovirus hexons by use of high-resolution X-ray crystallographic, molecular modeling, and sequence-based methods An adenovirus-based vaccine with a double-stranded RNA adjuvant protects mice and ferrets against H5N1 avian influenza in oral delivery models a placebo-controlled trial of immunization of HIV-1-infected persons with a replication-deficient adenovirus type 5 vaccine expressing the HIV-1 core protein Using the whole-genome sequence to characterize and name human adenoviruses A two-dose heterologous prime-boost vaccine regimen eliciting sustained immune responses to Ebola Zaire could support a preventive strategy for future outbreaks Recombination of the epsilon determinant and corneal tropism: human adenovirus species D types 15 A human type 5 adenovirus-based tuberculosis vaccine induces robust T cell responses in humans despite preexisting anti-adenovirus immunity Generation of adenovirus vectors devoid of all viral genes by recombination between inverted repeats Development and assessment of human adenovirus type 11 as a gene transfer vector Mapping the epitope of neutralizing monoclonal antibodies against human adenovirus type 3 Increasing the efficacy of oncolytic adenovirus vectors Community outbreak of adenovirus Epidemical features of HAdV-3 and HAdV-7 in pediatric pneumonia in Adenovirus vectors for gene therapy, vaccination and cancer gene therapy Characterization of culture-positive adenovirus serotypes from respiratory specimens in Fatal community-acquired pneumonia in children caused by re-emergent human adenovirus 7d associated with higher severity of illness and fatality rate Comparative genomic analysis of two strains of human adenovirus type 3 isolated from children with acute respiratory infection in southern China Construction and characterization of a replication-competent human adenovirus type 3-based vector as a livevaccine candidate and a viral delivery vector Comparative genomic analysis of two emergent human adenovirus type 14 respiratory pathogen isolates in China reveals similar yet divergent genomes A survey of recent adenoviral respiratory pathogens in Hong Kong reveals emergent and recombinant human adenovirus type 4 (HAdV-E4) circulating in civilian populations Molecular typing of human respiratory adenoviruses with universal PCR and sequencing primers for three major capsid genes: penton base, hexon, and fiber Re-emergent human adenovirus genome type 7d caused an acute respiratory disease outbreak in Southern China after a twenty-one year absence Comparison of viral and epidemiological profiles of hospitalized children with severe acute respiratory infection in Beijing and Construction and Characterization of a Novel HAdV-3 Vaccine Author Contributions QZ designed the experiments. A PCRderived product comprising the complete hexon gene (epsilon epitope) of adenovirus type 3 was directly cloned into the multiple cloning site of pShuttle using the EcoR V and Xho I restriction sites.
    keywords: adenovirus; cells; et al; gene; hadv-3; hexon; pcr; rad3h; recombinant; strain; type; vaccine
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        item: #14 of 39
          id: cord-033952-b9fxqnni
      author: Lu, Deng-Hui
       title: Hantavirus Infection during Pregnancy
        date: 2020-10-19
       words: 3736
      flesch: 39
     summary: Furthermore, no deaths have been reported in pregnant women infected with PUUV or DOBV (Hofmann et al. 2012; Ji et al. 2017; Partanen et al. 1993 ). Approximately 20,000 cases of hantavirusrelated diseases occur worldwide each year (Jiang et al. 2017) .
    keywords: et al; fever; hantavirus; infection; pregnancy; women
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        item: #15 of 39
          id: cord-259443-5sv3dwbs
      author: Banik, Gouri Rani
       title: Risk factors for severity and mortality in patients with MERS-CoV: Analysis of publicly available data from Saudi Arabia
        date: 2016-01-25
       words: 1668
      flesch: 48
     summary: The risk factors might vary geographically; additionally, the relatively small sample sizes in other studies could have missed other significant risk factors. Diabetes, hypertension, renal disease, malignancy, and several other conditions hitherto termed as miscellaneous conditions (e.g., anemia, obesity and congenital abnormalities, diseases of the liver and gall bladder, or steroid use) were significant risk factors for mortality from MERS-CoV (Table 1) .
    keywords: mers; risk
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        item: #16 of 39
          id: cord-261415-qxl14j2m
      author: Fu, Yajing
       title: Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools
        date: 2020-03-03
       words: 2609
      flesch: 29
     summary: In addition, given that uncontrolled pulmonary inflammation is likely a leading cause of fatality in SARS-CoV-2 infection, we also attempt to speculate possible therapeutic interventions that may be applied to attenuate inflammatory responses in order to reduce mortality (Fig. 2) . However, previous studies in animal models have shown that in SARS-CoV infection, such anti-S protein-neutralizing antibodies (anti-S-IgG) can also cause severe lung injury by altering inflammatory responses (Liu et al. 2019) .
    keywords: cov; infection; lung; responses; sars
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        item: #17 of 39
          id: cord-269021-juh2qkm0
      author: Bai, Zhihua
       title: The Rapid Assessment and Early Warning Models for COVID-19
        date: 2020-04-01
       words: 4607
      flesch: 37
     summary: The most classic infectious disease prediction and early warning models are the susceptible-infectious-recovered (SIR), susceptible-infectious-susceptible (SIS) and susceptible-infectious-recoverd-susceptible (SIRS) models. The establishment of a comprehensive assessment model, and the use of model analysis prediction, is very efficient for the early warning of infectious diseases.
    keywords: cases; cov-2; data; epidemic; et al; model; outbreak; sars; transmission
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        item: #18 of 39
          id: cord-273373-5elel6qo
      author: Wang, Haofeng
       title: Recent progress in the discovery of inhibitors targeting coronavirus proteases
        date: 2016-02-19
       words: 3087
      flesch: 35
     summary: Papain-like protease (PL pro ) ( Figure 1A ) exists as a functional domain within the large nsp3, which also encodes a ubiquitin-like fold, an ADP-ribose-1d-phosphatase domain, a SARS-CoV-unique domain, and a transmembrane domain (Lee et al., 2015) . PL pro recognizes a specific site comprising the consensus cleavage sequence LXGG between nsp1/2, nsp2/3 and nsp3/4 (Lee et al., 2015) .
    keywords: coronavirus; cov; et al; inhibitors; pro; sars
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        item: #19 of 39
          id: cord-273608-dxx3p1x5
      author: Deng, Jikui
       title: Respiratory virus multiplex RT-PCR assay sensitivities and influence factors in hospitalized children with lower respiratory tract infections
        date: 2013-04-11
       words: 3481
      flesch: 39
     summary: Multiplex RT-PCR; Respiratory viral loads; Cell culture; Lower respiratory tract infection Lower respiratory tract infections (LRTIs) are the most frequent cause of hospitalization among children worldwide (Ahn K M, et al., 1999; Garbino J, et al., 2004; Ruuskanen O, et al., 2011; Sung C C, et al., 2011; Thompson W W, et al., 2003; van Woensel J B, et al., 2003) . One NPS aliquot was used for a panel of respiratory viral pathogen detection by the ResPlex II Panel (Qiagen, Germany) (Li H, et al., 2007) .
    keywords: et al; multiplex; pcr; resplex
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        item: #20 of 39
          id: cord-273712-r2akpce8
      author: Wang, Jingjing
       title: Comparison of lentiviruses pseudotyped with S proteins from coronaviruses and cell tropisms of porcine coronaviruses
        date: 2016-02-19
       words: 2590
      flesch: 49
     summary: Infection of lentiviruses pseudotyped shows that S proteins from different CoVs have varied abilities to mediate pseudotyped virus infection in different cell types from different tissues. key: cord-273712-r2akpce8 authors: Wang, Jingjing; Deng, Feng; Ye, Gang; Dong, Wanyu; Zheng, Anjun; He, Qigai; Peng, Guiqing title: Comparison of lentiviruses pseudotyped with S proteins from coronaviruses and cell tropisms of porcine coronaviruses date: 2016-02-19 journal:
    keywords: cells; pedv; proteins; receptor; tgev
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        item: #21 of 39
          id: cord-274785-9jgg8ukr
      author: Zhang, Qiang
       title: Viral Regulation of RNA Granules in Infected Cells
        date: 2019-04-29
       words: 7401
      flesch: 28
     summary: RNA viruses modulate stress response pathway at different levels of SG formation (Table 1) : One is to regulate eIF2a phosphorylation, and the other is to regulate the process of SG nucleation. It seems that a portion of RNA viruses encode RNA binding proteins to antagonize the activity of PKR.
    keywords: assembly; bodies; cells; et al; formation; granules; host; infection; mrna; pkr; protein; replication; rna; stress; translation; virus; viruses
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        item: #22 of 39
          id: cord-284549-edliu3it
      author: Zhou, Hui
       title: Hepatitis C Virus NS2 Protein Suppresses RNA Interference in Cells
        date: 2019-11-27
       words: 4710
      flesch: 54
     summary: 1A , HCV NS2 protein can effectively restore the expression of RNAi-silenced EGFP (lane 4). Our results showed that the reversal effect of EGFP silencing could be observed at 48 hpt (Fig. 2C) , indicating that the VSR activity was dependent on the expression level of HCV NS2 protein.
    keywords: cells; dsrna; egfp; fig; hcv; ns2; protein; rnai; sirna
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        item: #23 of 39
          id: cord-295640-mhfu0e9r
      author: Wang, Wenling
       title: Improving Cross-Protection against Influenza Virus Using Recombinant Vaccinia Vaccine Expressing NP and M2 Ectodomain Tandem Repeats
        date: 2019-06-25
       words: 4812
      flesch: 41
     summary: Hence, there is an urgent need to develop universal vaccines against influenza virus. M2e specific antibody may play a protective role by antibody-dependent cell-mediated cytotoxicity (ADCC), although it could not neutralize influenza virus (Kim et al. 2017; Lee et al. 2015) .
    keywords: fusion; influenza; m2e; mice; rvj; vaccinia; virus; viruses
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        item: #24 of 39
          id: cord-298734-h286m32c
      author: Xia, Siyu
       title: Long Term Culture of Human Kidney Proximal Tubule Epithelial Cells Maintains Lineage Functions and Serves as an Ex vivo Model for Coronavirus Associated Kidney Injury
        date: 2020-06-29
       words: 4777
      flesch: 42
     summary: Pseudovirion assays demonstrated that SARS-CoV spike (S) protein was able to enter CR cells with luciferase reporter. CR cells (CRCs) maintain differentiation potential and lineage function in vitro Suprynowicz et al. 2012; Zhu et al. 2017) .
    keywords: ace2; cells; cov-2; covid-19; et al; human; kidney; kptecs; sars; study
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        item: #25 of 39
          id: cord-300466-sk9iilum
      author: Kong, Wen-Hua
       title: Serologic Response to SARS-CoV-2 in COVID-19 Patients with Different Severity
        date: 2020-07-23
       words: 2466
      flesch: 42
     summary: In this study, we, compared the results of serologic tests and nucleic acid test (NAT) from a group of COVID-19 patients in Wuhan, and analyzed the serologic IgM and IgG antibody level of patients with different disease severity. In this study, two NMPA approved M-CLIA kits were used to detect the level of SARS-CoV-2 IgM and IgG antibodies in the serum of COVID-19 patients.
    keywords: antibody; cov-2; covid-19; patients; sars
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        item: #26 of 39
          id: cord-312080-pu6m4qad
      author: He, Bing
       title: Three-dimensional cell culture models for investigating human viruses
        date: 2016-10-27
       words: 9047
      flesch: 28
     summary: This review summarizes and analyzes recent progress in human virological research with 3D cell culture models. To overcome these limitations associated with 2D monolayers and animal models, various types of 3D cell culture models have been developed (Edmondson et al., 2014) .
    keywords: 3d culture; cancer; cell; cell culture; culture; et al; hcv; hpv; human; infection; models; organotypic; raft; replication; research; system; tissue; virus; viruses
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        item: #27 of 39
          id: cord-315486-pjb5v1tc
      author: Wu, Xiaojun
       title: Different Laboratory Abnormalities in COVID-19 Patients with Hypertension or Diabetes
        date: 2020-09-30
       words: 1335
      flesch: 39
     summary: Are patients with hypertension and diabetes mellitus at increased risk for covid-19 infection? Effect of angiotensinconverting enzyme inhibition and angiotensin ii receptor blockers on cardiac angiotensin-converting enzyme 2 China Medical Treatment Expert Group for C (2020a) Comorbidity and its impact on 1590 patients with covid-19 in China: a nationwide analysis Clinical characteristics of coronavirus disease 2019 in China Risk factors associated with disease severity and length of hospital stay in covid-19 patients Temporal radiographic changes in covid-19 patients: relationship to disease severity and viral clearance Recent advances in immunity and hypertension Renin-angiotensin-aldosterone system inhibitors and risk of covid-19 Association of radiologic findings with mortality of patients infected with 2019 novel coronavirus in wuhan Clinical course and risk factors for mortality of adult inpatients with covid-19 in wuhan, China: a retrospective cohort study Sars-cov-2 viral load in upper respiratory specimens of infected patients Acknowledgements We acknowledge all the patients involved in this study, and appreciate all the frontline medical and nursing staff involved in the diagnosis and treatment of patients in Wuhan. What else might explain the poorer clinical outcomes of COVID-19 patients with hypertension or diabetes? To explore this question, we re-analysed the same cohort of 99 COVID-19 patients discharged from the general wards of Renmin Hospital of Wuhan University between 5 February 2020 and 14 March 2020 (Ethics approval No: WDRY2020-K124) (Liu et al. 2020a, b) .
    keywords: covid-19; diabetes; hypertension; patients
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        item: #28 of 39
          id: cord-319501-a2x1hvkk
      author: Wong, Lok-Yin Roy
       title: A molecular arms race between host innate antiviral response and emerging human coronaviruses
        date: 2016-01-15
       words: 7773
      flesch: 38
     summary: In a previous study, MERS-CoV M is shown to impede IFN production by preventing IRF3 translocation into the nucleus (Yang et al., 2013) . Among the five accessory proteins, ORF4a, ORF4b and ORF5 show the ability to dampen IFN production (Yang et al., 2013) .
    keywords: activation; coronavirus; cov; covs; et al; host; human; ifn; mers; production; proteins; rig; rna; sars; syndrome; type
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        item: #29 of 39
          id: cord-322005-70snojec
      author: Yao, Pingping
       title: Isolation and Growth Characteristics of SARS-CoV-2 in Vero Cell
        date: 2020-06-19
       words: 890
      flesch: 59
     summary: B Nucleotide mutations of isolated viruses at passage 3. E The multiple growth curve of isolated viruses.
    keywords: cov-2; fig; sars
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        item: #30 of 39
          id: cord-322166-ajolu2rh
      author: Yin, Jingchuan
       title: An overview of the highly pathogenic H5N1 influenza virus
        date: 2013-01-16
       words: 6922
      flesch: 39
     summary: A antibodies Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus Immunostimulatory motifs enhance antiviral siRNAs targeting highly pathogenic avian influenza H5N1 Avian influenza: our current understanding Immunology of avian influenza virus: a review A single amino acid in the PB2 gene of influenza A virus is a determinant of host range Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness Characteristics of stork feces-derived H5N1 viruses that are preferentially transmitted to primary human airway epithelial cells Inhibition of autophagy ameliorates acute lung injury caused by avian influenza A H5N1 infection Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice An Overview of the H5N1 Virus Virologica Sinica|www Early control of H5N1 influenza virus replication by the type I interferon response in mice Generation and comprehensive analysis of an influenza virus polymerase cellular interaction network Human H5N1 influenza: current insight into pathogenesis Highly pathogenic avian influenza H5N1 virus in cats and other carnivores Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a gammadelta T cell population in humanized mice Probable person-toperson transmission of avian influenza A (H5N1) Highly pathogenic avian influenza (H5N1): pathways of exposure at the animal-human interface, a systematic review H5N1 Virus Attachment to Lower Respiratory Tract Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals Ecology of avian influenza viruses in a changing world Quail carry sialic acid receptors compatible with binding of avian and human influenza viruses Avian influenza H5N1 an update on molecular pathogensis Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection Polyvalent DNA vaccines expressing HA antigens of H5N1 influenza viruses with an optimized leader sequence elicit cross-protective antibody responses NP, PB1 and PB2 viral genes contribute to altered replication of H5N1 avian influenza viruses in chickens The changing nature of avian influenza A virus (H5N1) Evolution and ecology of influenza A viruses A complicated message: Identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA Writing Committee of the Second World Health Organization Consultation on Clinical Aspects of Human Infection with Avian Influenza A (H5N1) V. 2008. Hence, interactions of current hosts and their environment influence the ability of H5N1 influenza viruses to spread to new and different hosts (Lowen A C, et al., 2007; Park A W, et al., 2007) .
    keywords: avian; cells; et al; h5n1; h5n1 virus; human; infection; influenza; influenza virus; protein; virus; viruses
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        item: #31 of 39
          id: cord-329876-4cgrjnjo
      author: Lei, Jian
       title: Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin
        date: 2016-05-30
       words: 6867
      flesch: 59
     summary: The papainlike protease (PL pro ) of MERS-CoV (or SARS-CoV) is involved in both of these tasks (Yang et al., 2013; Barretto et al, 2005) . The structure of PL pro can be divided into two parts: a ubiquitin-like (Ubl) domain and a catalytic domain with thumb, palm, and fingers subdomains.
    keywords: chain; complex; cov; cov pl; et al; mers; pl pro; pro; sars; ubiquitin
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        item: #32 of 39
          id: cord-332672-fbwz8oxp
      author: Wang, Manli
       title: Bats as animal reservoirs for the SARS coronavirus: Hypothesis proved after 10 years of virus hunting
        date: 2013-10-30
       words: 1116
      flesch: 50
     summary: After 10 years virus hunting, Ge et al. are now able to fill in important 316 missing links associated with SARS origin and epidemic (Fig. 1) . These bat isolates are more genetically diverse and share an overall nucleotide identity of 88% to 92% to the SARS-CoVs from humans or civets, resulting in the hypothesis that bats may be the natural hosts of SARS-CoV. However, there are still some missing links between previously characterized SL-CoVs from bats and SARS-CoV that precipitated the 2002-3 outbreaks.
    keywords: cov; sars
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        item: #33 of 39
          id: cord-332861-7b5pzmk6
      author: Zhang, Zhan
       title: Clinical Features and Treatment of 2019-nCov Pneumonia Patients in Wuhan: Report of A Couple Cases
        date: 2020-02-07
       words: 2085
      flesch: 58
     summary: It is speculated that the number of immune cells in the blood decreased due to a large number of them were lost or exuded to the infectious site to participate in the body's defense response. In this study, the male had a more severe decrease in immune cells and more severe conditions than the female.
    keywords: cells; female; patient; symptoms; urine
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        item: #34 of 39
          id: cord-333195-m4gvpsf8
      author: Lu, Renfei
       title: Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2
        date: 2020-04-01
       words: 1903
      flesch: 43
     summary: The severity of SARS-CoV-2 pandemic had exceeded SARS-CoV. In Jan. 30, 2020, The COVID-19 pandemic was declared as a public health emergency of international concern by WHO. Because LAMP amplification results in a significant pH change of buffer from an initial alkaline condition to a final acidic condition (Tanner et al. 2015) , the color change of cresol red from burgundy to orange or yellow indicates a positive reaction.
    keywords: assay; cov-2; detection; lamp; sars
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        item: #35 of 39
          id: cord-338606-6nk2ij20
      author: Abdel-Moneim, Ahmed S.
       title: WSV 2019: The First Committee Meeting of the World Society for Virology
        date: 2019-12-19
       words: 844
      flesch: 46
     summary: Other different topics were also thoroughly discussed, including online training, webinars, partnership with national and international societies and organizations, creating WSV educational resources, and determining the suitable time and place for the first WSV congress. The board members discussed the WSV Bylaws and the election of WSV officers.
    keywords: meeting; virology; wsv
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        item: #36 of 39
          id: cord-348467-a2e3f161
      author: Alqahtani, Amani Salem
       title: Camel exposure and knowledge about MERS-CoV among Australian Hajj pilgrims in 2014
        date: 2016-01-18
       words: 1568
      flesch: 51
     summary: In conclusion, many Australian Hajj pilgrims are not aware of MERS-CoV in Saudi Arabia, and some of them engage in activities that may put them at risk of MERS-CoV; therefore, there is a need for improved awareness among Hajj pilgrims and other travelers to the Middle East regarding MERS-CoV. Infection Prevention and Control Guidelines for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection Vector Borne Zoonotic Dis MERS, influenza and respiratory illness in travellers returning from the Hajj In this study, 62% of departing pilgrims were aware of the risk of contracting the disease from drinking raw camel milk while 21% were willing to drink camel milk if offered at Hajj.
    keywords: cov; hajj; mers; pilgrims
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        item: #37 of 39
          id: cord-352988-9ey3ir5e
      author: Xiang, Yang-fei
       title: Effects of 1,2,4,6-tetra-O-galloyl-β-D-glucose from P. emblica on HBsAg and HBeAg secretion in HepG2.2.15 cell culture
        date: 2010-10-08
       words: 1175
      flesch: 45
     summary: The cytotoxicity of 1246TGG on HepG2.2.15 as well as HepG2 cells was determined by observing cytopathic effects, and the effects of 1246TGG on secretion of HBsAg and HBeAg in HepG2.2.15 cells were assayed by enzyme immunoassay. Here, we investigated the anti-HBV activity of 1246TGG by detecting the HBsAg and HBeAg secretion levels in HepG2.2.15 cell culture, a cell line derived by transfection of cloned HBV DNA into human hepatoblastoma cell line HepG2 and used to assay for anti-HBV agents [4] .
    keywords: 1246tgg; hbeag; hbv; virus
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        item: #38 of 39
          id: cord-354529-k8p2u7iq
      author: Wu, Yongran
       title: Patients with Prolonged Positivity of SARS-CoV-2 RNA Benefit from Convalescent Plasma Therapy: A Retrospective Study
        date: 2020-08-31
       words: 3757
      flesch: 47
     summary: Chest CT findings of early and progressive phase COVID-19 infection from a US patient Use of convalescent plasma therapy in two COVID-19 patients with acute respiratory distress syndrome in Korea A case of long-term excretion and subclinical infection with Middle East respiratory syndrome coronavirus in a healthcare worker Use of convalescent plasma therapy in SARS patients in Hong Kong Chinese National Health Commission (2020) Recently, many studies about long-term viral duration in COVID-19 patients have been published Wan et al. 2020;
    keywords: covid-19; days; group; patients; sars; therapy
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        item: #39 of 39
          id: cord-356154-ifb3qiz7
      author: Zhang, Rong
       title: A Study of Two Cases Co-Infected with SARS-CoV-2 and Human Immunodeficiency Virus
        date: 2020-09-07
       words: 1067
      flesch: 48
     summary: In general, the blocking of the IL-6 receptor with tocilizumab has a particular effect on the treatment of COVID-19 patients with severe disease, but it may have little effect on patients with Fig. COVID-19 patients with immunodeficiency disease may cause more severe illness and poor treatment response due to the destruction of the immune system.
    keywords: patient; sars; treatment
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