id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cord-024076-q9fw7ch1	Manga, Pravin	Should ACE Inhibitors and Angiotensin Receptor Blockers Be Withdrawn in the Current Setting of COVID-19 Infection?	2020-04-17		.txt	text/plain	1865	56	28	key: cord-024076-q9fw7ch1 authors: Manga, Pravin title: Should ACE Inhibitors and Angiotensin Receptor Blockers Be Withdrawn in the Current Setting of COVID-19 Infection? date: 2020-04-17 journal: nan DOI: 10.18772/26180197.2020.v2nsia4 sha: doc_id: 24076 cord_uid: q9fw7ch1 nan The reports urging caution in the use of ACE inhibitors and ARBs for hypertension, diabetes and cardiovascular disease are based on laboratory data which found that SARS-CoV and COVID-19 virus binds to ACE 2 receptor which is found in the epithelial cells of the lung, kidney, intestine and blood vessels. In some experimental studies with animal models, it has been shown that there is increased expression and activity of ACE 2 in the heart and brain after treatment with ACE inhibitors and ARBs.(7)	cache/cord-024076-q9fw7ch1.txt	txt/cord-024076-q9fw7ch1.txt
