id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cord-290148-6cxndab8	Rossi, Gian Paolo	Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients	2020-04-06		.txt	text/plain	3173	74	23	Compelling evidence from animal models of ARDS, lung fibrosis, asthma, and chronic obstructive lung disease indicate that these effects are essential for ARDS to develop and that both ACEIs and ARBs block the disease-propagating effect of Ang II (Dhawale et al., 2016; Imai et al., 2005; Kaparianos and Argyropoulou, 2011) . Thus, blunting the ACE-1-Ang II-AT 1 R axis while enhancing the ACE-1-Ang II-AT 2 R, the ACE-2-Ang(1-7)-AT 2 R or the ACE-2-Ang(1-7)-MasR receptor axes ( Figure 1 , panel B) likely protects from ARDS triggered by infectious pathogens, including coronaviruses (Dhawale et al., 2016; Imai et al., 2005; Kaparianos and Argyropoulou, 2011; Meng et al., 2014) .	cache/cord-290148-6cxndab8.txt	txt/cord-290148-6cxndab8.txt
