item: #1 of 112 id: cord-000445-2x7dfl1q author: Paliwal, Sarvesh K. title: Neglected Disease – African Sleeping Sickness: Recent Synthetic and Modeling Advances date: 2011-05-10 words: 8700 flesch: 40 summary: Thus, because of high selectivity, excellent in vitro and in vivo activity compounds 66 and 32 can serve as a novel lead for further pre-clinical and clinical trials, but its cytotoxcity profile needs to be monitored during its evaluation. The given paper also attempts to investigate the relationship between the various physiochemical parameters and anti-trypanosomal activity that may be helpful in development of potent anti-trypanosomal agents against sleeping sickness. keywords: activity; analogues; anti; brucei; compounds; development; dna; drug; figure; pentamidine; rhodesiense; series; synthesis; vivo cache: cord-000445-2x7dfl1q.txt plain text: cord-000445-2x7dfl1q.txt item: #2 of 112 id: cord-000884-zq8kqf6h author: Shen, Hsin-Hui title: Reconstitution of Membrane Proteins into Model Membranes: Seeking Better Ways to Retain Protein Activities date: 2013-01-14 words: 6869 flesch: 36 summary: This review will discuss the reconstitution of membrane protein activities in four different types of model membrane—monolayers, supported lipid bilayers, liposomes and nanodiscs, comparing their advantages in membrane protein reconstitution. It is essential to find better solutions for retaining membrane protein activities for measurement and characterization in vitro. keywords: activity; atpase; bilayer; binding; interface; lipid; membrane; membrane proteins; model; nanodiscs; phospholipid; proteins; proteoliposomes; reconstitution; structure; water cache: cord-000884-zq8kqf6h.txt plain text: cord-000884-zq8kqf6h.txt item: #3 of 112 id: cord-001835-0s7ok4uw author: None title: Abstracts of the 29th Annual Symposium of The Protein Society date: 2015-10-01 words: 138771 flesch: 38 summary: In conclusion, the analysis of hydropathic environments strongly suggests that the orientation of a residue in a three-dimensional structure is a direct consequence of its hydropathic environment, which leads us to propose a new paradigm, interaction homology, as a key factor in protein structure. In computer simulation modeling of protein structure in a solvent medium, explicit, implicit, effectivemedium, approaches are often adopted to incorporate the effects of solvation. keywords: acid; activation; activity; addition; affinity; amino; amyloid; analysis; antibodies; antibody; antigen; approach; assay; assembly; associated; bacterial; binding; biology; bonds; cancer; catalytic; cell; cellular; chain; changes; characterization; chemical; chemistry; coli; complex; computational; concentration; conditions; conformation; conserved; control; core; cross; crystal; crystal structure; data; department; determine; development; dimer; disease; disordered; disordered proteins; dna; docking; domain; drug; effect; energy; enzyme; essential; experiments; expression; factors; family; fluorescence; fluorescent protein; formation; forms; fragments; free; functions; gene; group; helix; human; hydrogen; hydrophobic; important; increase; inhibitors; institute; key; kinetic; level; ligand; light; like; lipid; loop; low; major; mass; mechanism; membrane protein; method; model; modification; molecular; molecules; motif; mutant; mutations; n protein; native; nature; new; nmr; non; novel; number; oligomers; order; pathways; peptide; potential; prediction; presence; present; process; processes; properties; protease; protein; protein aggregation; protein association; protein complexes; protein concentration; protein data; protein degradation; protein design; protein domain; protein dynamics; protein engineering; protein evolution; protein expression; protein families; protein folding; protein function; protein interactions; protein interface; protein kinases; protein molecules; protein production; protein sequences; protein stability; protein structure; protein surface; protein tyrosine; provide; range; ray; reaction; receptor; recognition; recombinant; region; regulation; research; residues; response; results; rna; role; self; sequence; set; shows; signal; signaling; simulations; site; size; solution; species; specific; specificity; spectroscopy; stability; state; step; structural; studies; study; substrate; subunit; surface; synthetic; system; target; target protein; tau protein; techniques; temperature; terminal; time; transcription; transfer; transition; transmembrane; type protein; understanding; unfolding; university; use; variants; virus; vitro; wild; work; yeast cache: cord-001835-0s7ok4uw.txt plain text: cord-001835-0s7ok4uw.txt item: #4 of 112 id: cord-004879-pgyzluwp author: None title: Programmed cell death date: 1994 words: 81833 flesch: 47 summary: 8cl-2(z is a mitochondrial or perinuclear-associated oncoprotein that prolongs the life span of a variety of cell types by interfering with programmed cell death. Single and repetitive uptake and release of CPZ were measured in each cell type after individual exposure or exposure in any combination of cell types: In 2 hour competitive uptake studies fibreblasts reached 1.7 and 2.6 times the concentrations of C6-and ROC-cells, :respectively. keywords: acid; activation; activity; addition; adult; amino; analysis; animals; antibodies; binding; brain; calcium; cdna; cell lines; cells; changes; cloned; complex; concentrations; conditions; contrast; control; cultures; current; data; days; decrease; development; different; differentiation; dna; domain; early; effects; end; enzyme; epithelial; experiments; expression; extracts; factor; family; fold; form; formation; function; fusion; gene; gene expression; growth; homology; hormone; human; increase; induction; infected; inhibition; institut; interaction; intracellular; kda; kinase; levels; major; mammalian; mechanisms; medium; membrane; mice; molecular; mouse; mrna; muscle; mutant; nerve; neuronal; neurons; new; non; nuclear; nucleus; number; order; pathway; phosphorylation; play; positive; potential; presence; present; process; production; promoter; properties; protein; protein expression; rat; rate; rats; reaction; receptor; recombinant; recombination; region; regulation; release; replication; response; results; rna; role; sequence; signal; sites; species; specific; stage; stimulation; structure; studies; study; subunit; surface; synthesis; system; t cells; target; terminal; time; tissue; tnf; transcription; treatment; tumor; type; university; virus; vitro; vivo; yeast cache: cord-004879-pgyzluwp.txt plain text: cord-004879-pgyzluwp.txt item: #5 of 112 id: cord-004948-ad3i9wgj author: None title: 7th International Congress on Amino Acids and Proteins : Vienna, Austria, August 6–10, 2001 date: 2001 words: 73789 flesch: 41 summary: After the performic acid oxidation and the 6 M HCl hydrolysis of the protein, OPA/TATG (o-phthaldialdehyde/tetra-O-acetyl-1-thio--D-glucopiranoside) precolumn derivatisation method was used, and the enantiomers of sulphur containing amino acids were separated by RP-HPLC (LiChrosphere 100 RP-18e, 125 ϫ 4 mm, 5 µm column, Merck-Hitachi LaChrom HPLC). The dominant ones are water, ethanol, glycerol, sugars, organic acids, and various ions, while amino acids are present at much lower concentration. keywords: acids; activation; activities; activity; addition; administration; amino acid; analysis; animals; antagonists; apoptosis; approach; arginine; binding; biological; blood; brain; cancer; cell; chain; changes; clinical; complex; compounds; concentration; conditions; content; control; cysteine; data; decrease; department; derivatives; development; disease; dna; dopa; effect; enzyme; ethanol; experiments; expression; following; formation; free; function; gaba; gel; gene; glucose; glutamate; glutamine; group; growth; human; identification; increase; inhibition; institute; leucine; levels; liver; lysine; mass; mechanism; membrane; metabolism; methionine; method; mice; model; molecular; mrna; new; nmda; non; number; patients; peptide; plasma; polyamines; present; production; properties; proteins; rats; reaction; receptor; reduced; release; research; response; results; role; samples; sequence; stress; structure; studies; study; substrate; synthesis; system; taurine; time; tissue; transport; treatment; tumor; type; university; uptake; vitamin; vitro; vivo cache: cord-004948-ad3i9wgj.txt plain text: cord-004948-ad3i9wgj.txt item: #6 of 112 id: cord-005337-3f6pwyy3 author: Yoon, Hyun Kyung title: Recent development of highly sensitive protease assay methods: Signal amplification through enzyme cascades date: 2013-01-04 words: 4071 flesch: 38 summary: Proteases--invasion and more Protease-sensitive fluorescent nanofibers A genomic perspective on human proteases as drug targets Discovery of next generation inhibitors of HIV protease Matrix metalloproteinases: Multifunctional contributors to tumor progression Application of activitybased probes to the study of enzymes involved in cancer progression Proteases as therapeutics The control of prostate-specific antigen expression and gene regulation by pharmacological agents Cathepsin D in breast cancer: Mechanisms and clinical applications, a 1999 overview Fluorescent peptide probes for in vivo diagnostic imaging Imaging calpain protease activity by multiphoton FRET in living mice A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 7 (matrilysin) using monoclonal antibodies Application of in-gel protease assay in a biological sample: Characterization and identification of urokinase-type plasminogen activator (uPA) in secreted proteins from a prostate cancer cell line PC-3 Analysis of protease activity using quantum dots and resonance energy transfer Protease sensing with nanoparticle based platforms High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate Activity-based fingerprinting of proteases Activity based fingerprinting of proteases using FRET peptides Activity-based fingerprinting and inhibitor discovery of cysteine proteases in a microarray Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity Highly active and selective endopeptidases with programmed substrate specificities Using specificity to strategically target proteases Using GFP in FRET-based applications Highly adaptable and sensitive protease assay based on fluorescence resonance energy transfer Modified proenzymes as artificial substrates for proteolytic enzymes: Colorimetric assay of bacterial collagenase and matrix metalloproteinase activity using modified pro-urokinase Novel genetically encoded biosensors using firefly luciferase Noninvasive real-time imaging of apoptosis Redshifted Renilla reniformis luciferase variants for imaging in living subjects Protein modification by SUMO Active site and catalytic mechanism of phospholipase A2 Detection and characterization of SUMO protease activity using a sensitive enzyme-based reporter assay Beta-lactamase protein fragment complementation assays as in vivo and in vitro sensors of protein protein interactions Split ubiquitin as a sensor of protein interactions in vivo Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals Reprogramming control of an allosteric signaling switch through modular recombination Autoinhibitory domains: modular effectors of cellular regulation An autoinhibited coiled-coil design strategy for split-protein protease sensors Comprehensive panel of turn-on caspase biosensors for investigating caspase specificity and caspase activation pathways Specific and sensitive detection of nucleic acids and RNases using gold nanoparticle-RNA-fluorescent dye conjugates Proteolytic fluorescent signal amplification on gold nanoparticles for a highly sensitive and rapid protease assay The authors acknowledge financial support from the New Various methods have been developed to analyze protease activity, among which, protease assays based on resonance energy transfer are currently used most widely. keywords: activity; assay; enzyme; fret; luciferase; methods; protease; protein; signal; substrate cache: cord-005337-3f6pwyy3.txt plain text: cord-005337-3f6pwyy3.txt item: #7 of 112 id: cord-006230-xta38e7j author: None title: Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V. date: 2012-02-22 words: 136000 flesch: 40 summary: In in-vitro studies on rat and canine mast cells and human mast cell leukemia cells HMC1.2 BZ at micromolar concentrations inhibited mediator release which appeared to be related to an inhibition of the intracellular cAMP pathway. Previous work showed that mouse cells lacking the immediate-early gene c-fos are hypersensitive to ultraviolet (UVC) light. keywords: acid; activation; activity; acute; addition; adducts; agonist; aim; analysis; animals; anti; apoptosis; approach; assay; assessment; binding; blood; brain; calcium; camp; cancer; cancer cells; cardiac; cell line; cells; cellular; cgmp; changes; channels; chronic; clinical; complex; compounds; concentration; conclusion; conditions; contrast; control; current; damage; data; days; death; decrease; deficient; development; differences; differentiation; disease; dna; dose; drug; e.g.; effects; endothelial; enzyme; evidence; experiments; exposure; expression; factor; failure; family; fibroblasts; findings; fold; food; formation; function; für; g protein; gene; gene expression; germany; glucose; growth; health; heart; human; hypertrophy; increase; induction; inflammation; inhibition; inhibitors; institut; insulin; interaction; intracellular; kidney; kinase; leads; levels; like; line; liver; loss; low; lung; macrophages; mechanisms; membrane; methods; mice; model; mouse; mrna; muscle cells; mutations; nanoparticles; ndpk; non; novel; number; pain; pathway; patients; pcr; pharmakologie; phosphorylation; plasma; potential; presence; present; pressure; primary; processes; production; products; proliferation; promoter; properties; protein; protein expression; pulmonary; rats; receptor; reduced; regulation; release; response; results; risk; rkip; role; ros; samples; selective; signaling; site; skin; smooth; specific; stimulation; stress; studies; study; substances; subunits; synthesis; system; t cells; target; test; tested; therapy; time; tissue; toxicity; toxikologie; toxin; transcription; transport; treatment; tumor; tumor cells; type; universität; uptake; values; vascular; vitro; vivo; water cache: cord-006230-xta38e7j.txt plain text: cord-006230-xta38e7j.txt item: #8 of 112 id: cord-006860-a3b8hyyr author: None title: 40th Annual Meeting of the GTH (Gesellschaft für Thrombose- und Hämostaseforschung) date: 1996 words: 90772 flesch: 46 summary: The data show that children with low risk did in part receive higher doses of heparin and/or AT III concentrate than did high risk patients, whereas plasma therapy was adjusted to severity of eoagnlopathy. Inhibitor testing was done on patients plasma samples using the Bethesda method. keywords: activation; activity; acute; addition; age; agents; aggregation; analysis; antibodies; anticoagulant; anticoagulation; antigen; antithrombin; apc; aptt; assay; binding; bleeding; blood; blood coagulation; blood samples; cases; cells; children; clinical; clotting; coagulation; coagulation factor; complex; complications; concentrations; conclusion; contrast; control; coronary; correlation; count; data; day; days; deficiency; diagnosis; disease; dose; effect; elevated; endothelial; events; expression; factor; factor v; factor viii; family; fibrin; fibrinogen; formation; group; heparin; hirudin; hours; human; incidence; increase; influence; infusion; inhibitor; inr; laboratory; levels; low; mean; median; method; months; mutation; normal; order; parameters; patients; period; phase; plasma; plasma samples; plasminogen; platelet; platelet activation; platelet factor; present; products; protein; protein c; prothrombin; pts; range; reagent; receptor; reduced; release; resistance; response; results; risk; risk factor; role; samples; specific; studies; study; surface; surgery; system; test; therapy; thrombin; thrombosis; time; tissue; total; treatment; type; use; values; vascular; vein; venous; viii; vwf; weight; years cache: cord-006860-a3b8hyyr.txt plain text: cord-006860-a3b8hyyr.txt item: #9 of 112 id: cord-007084-4niom5mw author: POPPLEWELL, PHILIP Y. title: The Influence of Age on Steroidogenic Enzyme Activities of the Rat Adrenal Gland: Enhanced Expression of Cholesterol Side-Chain Cleavage Activity(*) date: 1987-06-01 words: 5311 flesch: 36 summary: P-450SCC: substrate binding and kinetics of cholesterol side-chain oxidation Purification and characterization of mitochondrial cytochrome P-450 associated with cholesterol side-chain cleavage from bovine corpus luteum Inhibition of cholesterol side chain cleavage by active site directed antibody to corpus luteum cytochrome P450 The differential development of mitochondrial cytochrome P-450 and the respiratory cytochromes in rat ovary Intracellular movement of cholesterol in rat adrenal cells: kinetics and effects of inhibitors On the mechanism whereby ACTH and cyclic AMP increase adrenal polyphosphoinositides: rapid stimulation of the synthesis of phosphatidic acid and derivatives of CDP ~ diacylglycerol Phosphoinositide metabolism and hormone action Adrenocorticotropic hormone-mediated changes in rat adrenal mitochondrial phospholipids Sterol carrier protein 2 : delivery of cholesterol from adrenal lipid droplets to mitochondria for pregnenolone synthesis Sterol carrier protein 2 : identification of adrenal sterol carrier protein 2 and site of action for mitochondrial cholesterol utilization Intramitochondrial movement of adrenal sterol carrier protein with cholesterol in response to corticotropin Scallen TJ 1985 Phospholipid, sterol carrier protein 2 and adrenal steroidogenesis Polyphosphoinositide activation of cholesterol side chain cleavage with purified cytochrome P-4508CC Brownie AC i983 Cholesterol side-chain cleavage in the rat adrenal cortex: isolation of a cycloheximide-sensitive activator peptide Modulation of the kinetics of cholesterol side-chain cleavage by an activator and by an inhibitor isolated from the cytosol of the cortex of bovine . keywords: activity; adrenal; chain; cholesterol; cleavage; cytochrome; enzyme; min; protein; rats cache: cord-007084-4niom5mw.txt plain text: cord-007084-4niom5mw.txt item: #10 of 112 id: cord-007682-01iom9al author: Harrigan, Jeanine title: Monitoring Target Engagement of Deubiquitylating Enzymes Using Activity Probes: Past, Present, and Future date: 2016-09-10 words: 5517 flesch: 26 summary: The utility of ubiquitin activity probes to identify and characterize DUBs in a number of conditions is not limited to ubiquitin. We will discuss the evolution of DUB activity probes, from in vitro assay development to their use in monitoring DUB activity in cells and in animal tissues, as well as recent progress and prospects for assessing DUB inhibition in vivo. otherwise distinct. keywords: abps; activity; development; dubs; enzymes; inhibitors; number; probes; profi; proteasome; protein; specifi; ubiquitin cache: cord-007682-01iom9al.txt plain text: cord-007682-01iom9al.txt item: #11 of 112 id: cord-008777-i2reanan author: None title: ECB12: 12th European Congess on Biotechnology date: 2005-07-19 words: 151661 flesch: 40 summary: During the process development for protein production, short time to market and the demand for cheap processes dominate today's process development. Interdependence of the impact of methanol and oxygen supply on protein production with recombinant Pichia pastoris N.K. Khatri, F. Hoffmann Martin-Luther-University Halle-Wittenberg, Institute for Biotechnology, Halle D-06120, Germany. keywords: acid; acid production; activities; activity; addition; adsorption; affinity; aim; alternative; amino; analysis; animal; ankara; antibody; application; applied; approach; assay; bacillus; bacteria; batch; bed; binding; biology; biomass; bioreactor; biosynthesis; biotechnology; capacity; carbon; case; cell; cell growth; cerevisiae; changes; chemical; chitosan; chromatography; coli; column; complex; composition; compounds; concentration; conditions; control; conversion; cost; cultivation; culture; data; days; degradation; denmark; department; design; development; differences; different; disease; dna; e.g.; effect; efficiency; energy; engineering; environmental; enzymatic; enzyme; enzyme activity; enzyme production; ethanol; ethanol production; experiments; expression; extract; factors; fed; fermentation; fermentation process; flow; flux; food; formation; function; gel; gene; gene expression; genome; glucose; group; growth; health; high; host; human; hydrolysis; identification; increase; induction; industrial; industry; influence; institute; interest; intracellular; knowledge; laboratory; level; limited; line; lipase; liquid; mail; mass; maximum; media; medium; metabolic; metabolites; method; microbial; microorganisms; milk; model; molecular; molecules; natural; network; new; niger; nitrogen; non; novel; number; oil; operation; optimization; order; oxygen; parameters; pathway; pcr; peptide; performance; phase; phosphate; plant; plasmid; potential; presence; present; procedure; process; processes; produce; production; production process; productivity; products; project; properties; protein; protein expression; protein production; purification; quality; range; rate; reaction; recombinant; regulation; removal; research; response; resulting; results; role; samples; scale; science; screening; separation; sequence; signal; source; species; specific; stability; state; step; strains; stress; structure; studies; study; substrate; sucrose; sugar; surface; synthesis; system; target; technical; technique; temperature; therapy; time; total; transfer; treatment; turkey; type; university; use; value; vitro; water; weight; work; yeast; yield cache: cord-008777-i2reanan.txt plain text: cord-008777-i2reanan.txt item: #12 of 112 id: cord-011038-5t8az1hf author: Mor, Satbir title: Synthesis, Type II diabetes inhibitory activity, antimicrobial evaluation and docking studies of indeno[1,2-c]pyrazol-4(1H)-ones date: 2019-10-26 words: 5540 flesch: 41 summary: (1H, d, J = 1.76 Hz, Ar-H) Discovery of novel antitubercular 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues POMA analyses as new efficient bioinformatics platform to predict and optimise bioactivity of synthesized 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues Inhibitory effect on key enzymes relevant to acute type-2 diabetes and antioxidative activity of ethanolic extract of artocarpus heterophyllus stem bark Synthesis, anticonvulsant activity and 3D-QSAR study of some prop-2-eneamido and 1-acetylpyrazolin derivatives of aminobenzothiazole Guanidinyl benzothiazole derivatives: Synthesis and structure activity relationship studies of a novel series of potential antimicrobial and antioxidants An automated quantitative assay for fungal growth inhibition Aldose reductase inhibitor zopolrestat restores allergic hyporesponsiveness in alloxan-diabetic rats search of new α-glucosidase inhibitors: Imidazolylpyrazole derivatives Synthesis and antimicrobial activity of novel structural hybrids of benzofuroxan and benzothiazole derivatives Novel 5-functionalized-pyrazoles: synthesis, characterization and pharmacological screening New series of benzothiazole and pyrimido[2,1-b]benzothiazole derivatives: synthesis, antitumor activity, EGFR tyrosine kinase inhibitory activity and molecular modeling studies Synthesis, antiasthmatic, and insecticidal/ antifungal activities of From these results, it is inferred that the compounds containing R 1 = CH 3 and R 2 = H, CH 3 , OCH 3 , Cl, and Br, are found to display more inhibitory activity against αglucosidase as compared with the remaining derivatives containing R 1 = i-propyl and i-butyl, and R 2 = H, CH 3 , OCH 3 , Cl, and Br, whereas no such trend was observed against α-amylase inhibitory activity. keywords: activity; amylase; compounds cache: cord-011038-5t8az1hf.txt plain text: cord-011038-5t8az1hf.txt item: #13 of 112 id: cord-012623-bc9fj29h author: Pekmezaris, Renee title: Participant-reported priorities and preferences for developing a home-based physical activity telemonitoring program for persons with tetraplegia: a qualitative analysis date: 2019-05-16 words: 4408 flesch: 47 summary: Regardless of the modality, telemonitoring physical activity programs often require minimal exercise equipment and are delivered at home on a personalized schedule. The purpose of this qualitative study was to explore perceptions and priorities of persons with spinal cord injury (SCI) for physical activity and to incorporate their feedback to inform future development of a physical activity program delivered via a telemonitoring platform. keywords: activity; cord; exercise; function; injury; participants; persons; program; sci; spinal cache: cord-012623-bc9fj29h.txt plain text: cord-012623-bc9fj29h.txt item: #14 of 112 id: cord-013176-6ckuya1w author: Ninfali, Paolino title: Antiviral Properties of Flavonoids and Delivery Strategies date: 2020-08-21 words: 8135 flesch: 29 summary: Front Antiviral Phytochemicals: An Overview Flavonoids: Promising natural compounds against viral infections Antiviral effects of phytochemicals from medicinal plants: Applications and drug delivery strategies Antiviral activity of Disticella elongata (Vahl) Urb. Concerning the combination of flavonoids in an antiviral cocktail, each phytochemical may be used initially at a concentration of about 0.5 g/day with the aim of reaching an intake of 3 g/day of antiviral flavonoids. keywords: activity; anti; bioavailability; cells; delivery; drugs; effects; flavonoids; hcv; influenza; inhibition; phytochemicals; protein; quercetin; replication; rna; virus cache: cord-013176-6ckuya1w.txt plain text: cord-013176-6ckuya1w.txt item: #15 of 112 id: cord-016089-h122of8q author: Li, Haixia title: Lonicera japonica Thunb 金银花 (Jinyinhua, Honey Suckle) date: 2015-02-19 words: 2835 flesch: 40 summary: These include Jinyinhua beverage, Jinyinhua candy, and Jinyinhua soup etc. A typical way is to boil 100 g mung bean and a piece of ginger in 1 liter of water before adding 30 g Jinyinhua, then continuously boil until the mung bean cracks and are fully cooked. keywords: acid; activities; anti; diseases; japonica; jinyinhua; lonicera; oil cache: cord-016089-h122of8q.txt plain text: cord-016089-h122of8q.txt item: #16 of 112 id: cord-016362-d3cpy37g author: Orhan, Ilkay title: Antiviral and Antimicrobial Evaluation of Some Heterocyclic Compounds from Turkish Plants date: 2007-08-01 words: 4378 flesch: 38 summary: In one of our recent studies, five diterpenoid-derivative alkaloids, lycoctonine (9), 18-O-methyllycoctonine (10), delcosine (11), 14acetyldelcosine (12), and 14-acetylbrowniine (13) (as shown in Fig. 3) were screened for their antibacterial, antifungal, and antiviral activities In our recent work, we focused on investigation of antiviral activity of 33 isoquinoline alkaloids and seven derivatives of them, which are classified as protopine-type [protopine (14) and β-allocryptopine keywords: activity; alkaloids; aureus; compounds; effect; study cache: cord-016362-d3cpy37g.txt plain text: cord-016362-d3cpy37g.txt item: #17 of 112 id: cord-016575-bn15006x author: Cox-Georgian, Destinney title: Therapeutic and Medicinal Uses of Terpenes date: 2019-11-12 words: 9861 flesch: 46 summary: This was studied by Astani et al. Cannabis is one of the most common sources for the medicinal terpene (Franklin et al. 2001 ). keywords: activity; anti; cancer; depression; diabetes; drugs; effects; et al; footnote; franklin; franklin et; limonene; medicine; monoterpenes; natural; oil; pathway; pinene; plants; properties; study; terpenes cache: cord-016575-bn15006x.txt plain text: cord-016575-bn15006x.txt item: #18 of 112 id: cord-017131-rx1z4orm author: Patra, Amlan Kumar title: An Overview of Antimicrobial Properties of Different Classes of Phytochemicals date: 2012-02-18 words: 10595 flesch: 30 summary: Coumarins exhibit a broad diversity for antimicrobial activity. Detailed information of antimicrobial activities of fl avonoids has been discussed elsewhere in this book (Chap. 2 ). keywords: acid; activities; activity; antibacterial; antifungal; aureus; bacteria; coli; compounds; effects; et al; extracts; fungi; gram; group; growth; negative; pathogenic; phytochemicals; plants; properties; saponins; strains; virus cache: cord-017131-rx1z4orm.txt plain text: cord-017131-rx1z4orm.txt item: #19 of 112 id: cord-017504-rtg7fs82 author: Lim, T. K. title: Punica granatum date: 2012-11-03 words: 31407 flesch: 35 summary: Oral administration of pomegranate juice extract (100 and 300 mg/kg) to angiotensin-II treated rats for 4 weeks signi fi cantly reduced the mean arterial blood pressure and vascular reactivity changes to various catecholamines (Waghulde et al. 2010 ) . The results suggested that pomegranate juice extract could prevent the development of high blood pressure induced by angiotensin-II probably by combating the oxidative stress and antagonizing the physiological actions of angiotensin-II. keywords: acid; activity; administration; antioxidant; cancer; cells; compounds; consumption; content; effect; ellagic; ellagic acid; et al; expression; extract; fruit; fruit extract; glucose; glutathione; granatum; growth; human; inhibition; juice; levels; lipid; mice; oil; oral; patients; peel; peel extract; polyphenols; pomegranate; pomegranate extract; pomegranate fl; pomegranate juice; prostate; protein; punica; punica granatum; punicalagin; rats; results; rind; seed; serum; signi; signi fi; skin; stress; studies; study; total; treatment cache: cord-017504-rtg7fs82.txt plain text: cord-017504-rtg7fs82.txt item: #20 of 112 id: cord-020010-q58x6xb0 author: None title: 19th ICAR Abstracts: date: 2006-03-13 words: 46881 flesch: 40 summary: Although anti-inflammatory agents are not very active in vitro, it is thought that they might be efficacious in reducing any deleterious inflammatory response associated with virus infections such as SARS infections in humans. Although only BTCRB and BDCRB were inhibitors of the ATPase activity, two other compounds, dBDCRB and Cl4RB, inhibited virus replication in a plaque-reduction assay, thus indicating that those have a different mode of action. keywords: acid; action; activity; agents; animals; antiviral; assay; cdv; cells; combination; compounds; concentrations; containing; control; culture; days; department; derivatives; development; disease; dna; dose; drug; effect; efficacy; gene; hcv; hiv; human; infection; influenza; influenza virus; inhibited; inhibition; inhibitors; institute; mice; model; molecular; mutations; new; novel; nucleoside; polymerase; potent; potential; presence; present; properties; protein; reduction; replication; research; resistance; results; rna; specific; strain; structure; studies; study; synthesis; system; target; tested; therapeutic; therapy; treatment; type; university; usa; virus; virus infection; virus replication; viruses; vitro; vivo cache: cord-020010-q58x6xb0.txt plain text: cord-020010-q58x6xb0.txt item: #21 of 112 id: cord-021419-nypnib0h author: Olsufyeva, Evgenia N. title: Main trends in the design of semi-synthetic antibiotics of a new generation date: 2020-03-17 words: 16294 flesch: 41 summary: Different approaches to the search for new compounds were developed in recent years. Such comprehensive studies can lead to the design and synthesis of new-generation drugs, which would be more effective than the starting antibiotics and which are of theoretical interest as new compounds with high biological activity. keywords: acid; activity; aglycone; amino; analogues; antibiotics; cell; compound; derivatives; dna; eremomycin; gram; group; modification; new; olivomycin; presence; reaction; scheme; series; starting; strains; synthesis; treatment; vancomycin cache: cord-021419-nypnib0h.txt plain text: cord-021419-nypnib0h.txt item: #22 of 112 id: cord-021897-yeih3tfo author: Page, Stephen J. title: Tourism today: Why is it a global phenomenon embracing all our lives? date: 2011-10-28 words: 11887 flesch: 40 summary: The first wave of internet technology created an online travel community where tourism businesses were able to market and communicate with consumers through electronic media. There are five main reasons why measuring tourism is important: 1 to understand why and how significant it is for certain destinations, countries and regions in terms of the scale and value of the visitors 2 to understand how important it is for countries in terms of their balance of payments, as it is an invisible export that generates foreign currency and income 3 to assist the tourism industry and governments in planning for and anticipating the type of infrastructure which is required for tourism to grow and prosper 4 to assist in understanding what type of marketing is needed to reach the tourist as a consumer, and what factors will influence tourists to visit a country or destination 5 to help the tourism industry make decisions about what type of action is needed to develop tourism businesses. keywords: activity; business; countries; destination; holiday; industry; leisure; level; management; people; sector; services; supply; time; tourism; tourism industry; tourists; travel cache: cord-021897-yeih3tfo.txt plain text: cord-021897-yeih3tfo.txt item: #23 of 112 id: cord-022779-himray6q author: None title: Abstracts of oral presentations date: 2005-06-10 words: 3624 flesch: 39 summary: This procedure -called SICLOPPS for Split Intein Circular Ligation Of Peptides and ProteinS-provides a biosynthetic pathway for peptides that are metabolically stable, and can be produced with spatial and temporal control We will present the results of the work which involves our intensive effort in: • Development of the method for monitoring and analyzing quality of peptide chip synthesis • Improvement in peptide chip synthesis • Development of the methods for quantitative analysis of (a) the specific binding of antibodies/proteins to peptides on chip and (b) kinase enzymatic activities against substrate peptides on chip. keywords: -sheet; acid; activity; chemical; ligation; method; peptides; properties; protein; results; structure cache: cord-022779-himray6q.txt plain text: cord-022779-himray6q.txt item: #24 of 112 id: cord-022940-atbjwpo5 author: None title: Poster Sessions date: 2016-09-07 words: 241687 flesch: 44 summary: Among used cancer cell lines, ERICD was highly expressed and ARID3A had lower expression in U-2OS (osteosarcoma), A-172 (glioblastoma) and A549 (lung cancer). Clear cell renal cell cancer (ccRCC) with metastases has pour prognosis: 5-year survival is about 9%. keywords: a549 cells; acid; activation; activities; activity; activity levels; acute; addition; administration; affinity; agents; aim; albumin; allele; alterations; alternative; amino; analysis; analysis results; animals; ankara; anti; antibodies; antibody; anticancer; antioxidant; apoptosis; applications; approach; assay; association; bacteria; beta; binding; biology; blood; body; bone; brain; breast cancer; cancer cells; cancer group; cancer patients; cancer stem; cancer treatment; cancers; cause; cell cycle; cell death; cell growth; cell lines; cell proliferation; cell survival; cell viability; changes; characterization; chemical; cholesterol; chronic; clinical; coli; colorectal; combination; comparison; complex; complexes; compounds; concentrations; conclusion; conditions; content; control cells; control group; control study; controls; correlation; culture; curcumin; current; cytotoxic; damage; data; day; days; decrease; department; detection; determination; development; diabetes; differences; differentiation; discussion; disease; dna; domain; dose; drug; effects; elevated; elisa; energy; enzyme; enzyme activity; ethanol; experimental; expression analysis; expression levels; expressions; extract; factor; faculty; family; fat; findings; flow; fluorescence; fold; food; formation; free; function; gene expression; genes; genetic; genome; genotype; glucose; glutathione; group; growth; gsh; health; hours; human; immune; increase; inflammation; inflammatory; inhibition; inhibitors; injury; institute; insulin; interaction; intracellular; introduction; invasion; investigation; ischemia; kinase; laboratory; lead; levels; light; like; lipid; liver; low; lung; male; manner; markers; mass; materials; matrix; mcf-7; mda; mda levels; mean; mechanisms; medical; medicine; medium; membrane; metabolism; methods; methylation; mice; microscopy; migration; mirnas; mitochondrial; model; modified; molecular; molecules; mrna; muscle; mutant; mutations; n =; nanoparticles; negative; non; normal; novel; number; obese; obesity; oil; order; oxidative; oxygen; p =; p-02.08.5; parameters; pathway; patients; pcr; peptide; phase; plant; plasma; play; point; polymorphisms; population; potential; presence; present; process; processes; production; products; profile; progression; promoter; properties; prostate; prostate cancer; protective; protein; protein expression; protein levels; purpose; radical; range; rate; rats; reaction; receptor; recombinant; region; regulation; related; relationship; research; resistance; response; results; risk; role; samples; science; scientific; screening; sequence; serum; serum levels; signaling; site; size; sod; species; specific; stability; stage; status; stem cells; strain; stress; structure; studies; study; study group; subjects; surface; survival; synthesis; system; target; technique; temperature; test; tested; therapeutic; therapy; time; tissue; tnf; total; transcription; treatment; treatment group; tumor; tumor cells; turkey; type; university; use; values; vitamin; vitro; water; weight; western; wild; women; work; years cache: cord-022940-atbjwpo5.txt plain text: cord-022940-atbjwpo5.txt item: #25 of 112 id: cord-022955-vy0qgtll author: None title: Proteases date: 2005-06-20 words: 36483 flesch: 40 summary: Specific molecular associations or shared scaffolds between the involved proteases and/or protein inhibitors and defined three-dimensional structures have also been reported. It was used affinity chromatography, electrophoresis, western-blotting, ELISA, determination of proteins activity. keywords: acid; activation; activities; activity; amino; analysis; binding; brain; calcium; cancer; catalytic; cells; cleavage; complex; control; degradation; domain; effect; enzyme; expression; factor; family; form; function; gcpii; gene; growth; human; hydrolysis; inhibition; inhibitors; levels; like; mail; mechanism; membrane; model; molecular; pathway; peptide; presence; present; protease; protease activity; protease inhibitors; protein; proteolysis; regulation; results; role; sequence; serine; serine protease; site; specificity; structure; studies; study; substrate; system; target; terminal; treatment; trypsin; type; ubiquitin; vitro; zymogen cache: cord-022955-vy0qgtll.txt plain text: cord-022955-vy0qgtll.txt item: #26 of 112 id: cord-023208-w99gc5nx author: None title: Poster Presentation Abstracts date: 2006-09-01 words: 71178 flesch: 41 summary: Peptide structures can be approached by spectroscopy and NMR techniques but data from these approaches too frequently diverge. To increase the stability and the therapeutic efficacy of peptide sequences from myelin oligodendrocyte protein (MOG) that act as multiple sclerosis (MS) antigens, we grafted them onto a framework of a particularly stable class of peptides, the cyclotides. keywords: acid; activation; activity; affinity; aggregation; aim; alpha; amino; amino acid; analogues; analysis; approach; arg; assay; beta; binding; blood; bond; cancer; cell; chain; chemical; chemistry; complex; complexes; compounds; concentration; conformational; conjugates; cyclic; data; derivatives; design; development; disulfide; dna; domain; effect; enzyme; epitope; fmoc; fragment; gly; group; growth; hplc; human; inhibitors; integrin; interaction; ligands; mechanism; membrane; method; mice; model; molecular; molecules; native; new; nmr; non; novel; opioid; order; patients; peptide; peptide analogues; peptide chain; peptide synthesis; phase; phase peptide; phe; position; potential; prepared; presence; products; proline; properties; protein; reaction; receptor; residues; results; role; sequence; site; solution; specific; spectroscopy; stability; strategy; structure; studies; study; surface; synthetic; system; target; terminal; therapeutic; treatment; tumor; turn; type; tyr; use; vivo; water; work cache: cord-023208-w99gc5nx.txt plain text: cord-023208-w99gc5nx.txt item: #27 of 112 id: cord-023209-un2ysc2v author: None title: Poster Presentations date: 2008-10-07 words: 112272 flesch: 42 summary: A specifi c bioassay was developed for screening peptides activity in high salinity conditions in order to evaluate the inhibition of biofi lm growth, based on growing biofi lmforming bacteria in a 96-wells microtiter plate. The insight into the molecular mechanism of peptides activity is obtained in vitro using SAXS method and artifi cial systems mimicking a bacterial cytoplasmic membrane. keywords: acid peptide; acid residues; acids; activation; activities; activity; affi; agents; aggregation; aim; ala; amide; amino; amino acid; amyloid; analogs; analogues; analysis; antimicrobial; application; approach; assay; backbone; binding; biological; blood; bond; brain; c peptide; cancer; cation; cell; chemical; chemistry; cient; city; coil; complex; compounds; concentration; conditions; confi; conformational; conjugates; coupling; cyclic; data; delivery; derivatives; design; development; diseases; dna; domain; drug; ed peptides; effect; effi; experiments; family; fmoc; formation; fragments; free; function; gly; group; helix; hplc; human; identifi; infl; inhibition; inhibitors; interaction; interest; leu; ligation; lipid; mass; mechanism; membrane; method; microwave; model; model peptides; modifi; modifi ed; molecules; native; natural; new; nity; nmr; non; novel; number; order; peptide; peptide analogues; peptide bond; peptide chain; peptide chemistry; peptide fragments; peptide library; peptide ligands; peptide sequence; peptide structure; peptide synthesis; phase peptide; phase synthesis; phe; position; positive; potential; presence; present; process; processes; properties; protein; purifi; range; reaction; receptor; recognition; region; report; residues; results; role; rst; selective; sequence; signifi; site; solution; specifi c; spectroscopy; stability; stable; strategy; structure; studies; study; surface; synthetic; system; target; terminal; terminus; therapy; time; treatment; trp; tumor; type; university; uorescence; uptake; use; vitro; vivo; water; work cache: cord-023209-un2ysc2v.txt plain text: cord-023209-un2ysc2v.txt item: #28 of 112 id: cord-023225-5quigar4 author: None title: Posters date: 2012-08-21 words: 70555 flesch: 41 summary: Aim of this study is the introduction, in the type 1' β turn peptide structure, of the sugar moiety specific for anti-gangliosides antibody recognition by synthesizing specific building blocks. Peptide synthesis was used to verify the accuracy of the determined sequence and to prepare sufficient peptide amount for biological activity studies. keywords: acid; activity; addition; affinity; agents; aggregation; aib; aim; amino; amino acid; amyloid; analogs; analogues; analysis; approach; bacteria; binding; biological; blood; bond; cancer; cell; chain; chemical; chemistry; class; complex; compounds; conditions; conformation; cyclic; cys; data; derivatives; design; development; disease; disulfide; dna; drug; effect; fmoc; formation; function; gly; group; helical; helix; human; hydrophobic; increase; inhibitor; interactions; leu; linear; mechanism; membrane; method; model; moiety; molecules; new; nmr; non; novel; order; peptide; peptide analogues; peptide sequence; peptide synthesis; phase; phase peptide; phe; position; potential; presence; present; process; properties; protein; reaction; receptor; residues; resin; results; role; selective; selectivity; sequence; series; site; solution; specific; specificity; stability; strategy; structure; studies; study; synthetic; system; target; terminal; terminus; treatment; type; university; use; vivo; water; work cache: cord-023225-5quigar4.txt plain text: cord-023225-5quigar4.txt item: #29 of 112 id: cord-024652-4i6kktl0 author: Santra, Hiran Kanti title: Natural Products as Fungicide and Their Role in Crop Protection date: 2020-05-12 words: 20776 flesch: 25 summary: to echinocandin LY303366, itraconazole and amphotericin B Biochemical defense mechanisms in cotton plants against Ramularia leaf spot mediated by silicon In vitro antifungal activity of 2-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1-methylethyl pentanoate, a dihydro -pyrrole derivative Phytoalexin accumulation in tissues of Brassica napus inoculated with Leptosphaeria maculans Naphthalene, an insect repellent, is produced by Muscodor vitigenus, a novel endophytic fungus Activities of essential oils from Asarum heterotropoides var. mandshuricum against five phytopathogens Antagonist actinomycetes metabolites against plant pathogens fungi of agricultural importance Induction of phytoalexins and proteins related to pathogenesis in plants treated with extracts of cutaneous secretions of southern Amazonian Bufonidae amphibians Natural products in crop protection Bioassay-guided isolation of allelochemicals from Avena sativa L.: allelopathic potential of flavone C-glycosides Antifungal activity of crude extracts from brown and red seaweeds by a supercritical carbon dioxide technique against fruit postharvest fungal diseases Rhizospheric streptomycetes as potential biocontrol agents of Fusarium and Armillaria pine rot and as PGPR for Pinus taeda Geldanamycin, a new antibiotic Induction of Fusarium solani mutants insensitive to tomatine, their pathogenicity and aggressiveness to tomato fruits and pea plants Molecular engineering of resveratrol in plants Antifungal properties of surangin B, a coumarin from Mammea longifolia Phytochemical analysis and antifungal activity of moss Bryum cellulare against some phytopathological fungi Studies on antifungal potential of Bryum cellulare against spore germination of fungus Curvularia lunata In vitro antifungal activity of Plagiochasma appendiculatum against Alternaria solani Evaluation of bryophyte for green fungicides as alternative treatment to control plant pathogen Oxidative ring contraction of the phytoalexin cyclobrassinin: a way to brassilexin Brassilexin, a novel sulphur-containing phytoalexin from Brassica juncea L., (cruciferae) Nees against sporulation and growth of postharvest phytopathogenic fungi Evaluation of Streptomyces griseorubens E44G for the biocontrol of Fusarium oxysporum f. sp. lycopersici: ultrastructural and cytochemical investigations Interactions between a root-knot nematode (Meloidogyne exigua) and arbuscular mycorrhizae in coffee plant development (Coffea arabica) Foliar epicuticular wax of Arrabidaea brachypoda: flavonoids and antifungal activity Metabolites of Helminthosporium monoceras: structures of monocerin and related benzopyrans Trans-trans-3, 11-tridecadiene5, 7, 9-triyne-1,2-diol, an antifungal polyacetylene from diseased safflower (Carthamus tinctorius) Mycofumigation by the volatile organic compound-producing fungus Muscodor albus induces bacterial cell death through DNA damage Mycorrhizal fungi and Trichoderma harzianum as biocontrol agents for suppression of Rhizoctonia solani damping off disease of tomato Effect of volatile metabolites of Trichoderma species against seven fungal plant pathogens in vitro Production of gliotoxin on natural substrates by Trichoderma virens Studies on antagonistic effect against plant pathogenic fungi from endophytic fungi isolated from Houttuynia cordata Thunb. keywords: acid; actinomycetes; activities; activity; agent; albus; antibiotics; antifungal; antimicrobial; bioactive; biocontrol; botrytis; cell; chemical; cinerea; compounds; control; crop; defense; disease; effect; endophytic; et al; extracts; fruits; fungi; fungus; fusarium; growth; host; infection; isolation; leaf; loss; metabolites; muscodor; mycorrhizal; nature; novel; oils; pathogens; penicillium; phytoalexins; phytopathogenic; plant; plant growth; potential; production; products; resistance; rhizoctonia; rice; root; rot; soil; solani; source; species; streptomyces; use; vitro cache: cord-024652-4i6kktl0.txt plain text: cord-024652-4i6kktl0.txt item: #30 of 112 id: cord-027712-2o4svbms author: Urošević, Vladimir title: Baseline Modelling and Composite Representation of Unobtrusively (IoT) Sensed Behaviour Changes Related to Urban Physical Well-Being date: 2020-05-31 words: 4143 flesch: 15 summary: Physical activity level as a single measure is mainly expressed in terms of time spent and calories burned while performing light/soft, moderate, and intense/vigorous physical activity. From several existing elementary statistical approaches for aggregating the underlying dimensional indices and constructing the summary composite indicator value, we consider the weighted geometric mean of the four constituting dimensional indices as most adequate and appropriate for this specific well-being problematics: where summary dimensional indices denoted by the scoring function values are: I wwalking activity index, I pphysical activity/exercise index, I ssleep duration index, I ccardio-respiratory fitness index (through VO 2 max), and Wt w , Wt p , Wt s , and Wt c are respective weight factors, derived from expert assessments and rank data from relevant previous studies and experience, and assigned to adjust the relative importance and contribution of each of the indices to the resulting composite indicator value, per compositing methods outlined in [19] and [9] , or for derivation of composite UN Human Development Index (HDI). keywords: activity; approach; composite; data; devices; health; indicators; max; sleep; values cache: cord-027712-2o4svbms.txt plain text: cord-027712-2o4svbms.txt item: #31 of 112 id: cord-027713-8ohchx8p author: Abidine, M’hamed Bilal title: Human Activities Recognition in Android Smartphone Using WSVM-HMM Classifier date: 2020-05-31 words: 2355 flesch: 44 summary: Impact of smartphone's on society Improving human activity recognition in smart homes Healthcare in the pocket: mapping the space of mobile-phone health interventions An automatic data mining method to detect abnormal human behaviour using physical activity measurements A survey of online activity recognition using mobile phones Human Activity Recognition and Prediction Smart phone based data mining for human activity recognition Human activity recognition on smartphones using a multiclass hardware-friendly support vector machine SARM: salah activities recognition model based on smartphone Human activities recognition in android smartphone using support vector machine Subject-independent human activity recognition using smartphone accelerometer with cloud support Towards physical activity recognition using smartphone sensors Soft margin SVM modeling for handling imbalanced human activity datasets in multiple homes Pattern recognition of human activity based on smartphone data sensors using SVM multiclass HMM machine learning and inference for Activities of Daily Living recognition Principal Component Analysis Support vector machines: training and applications Controlling the sensitivity of support vector machines Weighted support vector machine for classification with uneven training class sizes The joint use of sequence features combination and modified weighted SVM for improving daily activity recognition HMM machine learning and inference for activities of daily living recognition A practical guide to support vector classification Activity recognition using cell phone accelerometers ), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. Recently, smart phones, equipped with a rich set of sensors, are explored as alternative platforms for human activity recognition (HAR) keywords: activities; activity; data; hmm; recognition; wsvm cache: cord-027713-8ohchx8p.txt plain text: cord-027713-8ohchx8p.txt item: #32 of 112 id: cord-034066-fsp7e5x5 author: Di Figlia-Peck, Stephanie title: Treatment of children and adolescents who are overweight or obese date: 2020-10-21 words: 10692 flesch: 39 summary: The researchers concluded that CAAT holds promise as a treatment modality since overweight and obese children are often less effective in regulating food intake compared to normal weight children. Several studies of weight management interventions have shown that children can successfully increase their step count from baseline as part of an intervention. keywords: activity; adolescents; bmi; change; children; eating; food; group; health; interventions; loss; management; obesity; overweight; program; school; surgery; time; treatment; weight cache: cord-034066-fsp7e5x5.txt plain text: cord-034066-fsp7e5x5.txt item: #33 of 112 id: cord-102632-yazl9usb author: Lobet, Guillaume title: QuoVidi: a open-source web application for the organisation of large scale biological treasure hunts date: 2020-07-01 words: 4497 flesch: 60 summary: Students living in an urban area were potentially at a disadvantage compared to students in the countryside. This is why we created a second module in the interface, the photo quiz, which allowed students to learn from photos contributed by other students, without having to submit their own photos. keywords: activity; animal; learning; pictures; platform; quests; students; web cache: cord-102632-yazl9usb.txt plain text: cord-102632-yazl9usb.txt item: #34 of 112 id: cord-252108-04xr5xdl author: Havrylyuk, Dmytro title: Synthesis and biological activity evaluation of 5-pyrazoline substituted 4-thiazolidinones date: 2013-06-06 words: 3618 flesch: 43 summary: Yield 86%, mp 268e269 C 46 (d, 2H, J ¼ 6.4 Hz, arom), 7.21 (d, 2H, J ¼ 6.4 Hz, arom), 6.90 (br. s, 3H, arom), 5.68 (dd, 1H, CH 2 CH 4-Thiazolidones: centenarian history, current status and perspectives for modern organic and medicinal chemistry Biological activities of pyrazoline derivatives e a recent development Recent advances in the therapeutic applications of pyrazolines Structureeactivity relationship study of a novel necroptosis inhibitor Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-a 2-Thiazolylimino/heteroarylimino-5-arylidene-4-thiazolidinones as new agents with SHP-2 inhibitory action Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity Synthesis of new 4-azolidinones with 3,5-diaryl-4,5-dihydropyrazole moiety and evaluation of their antitumor activity in vitro Synthesis, cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi Synthesis and structureeactivity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi First small molecular inhibitors of T. brucei dolicholphosphate mannose synthase (DPMS), a validated drug target in African sleeping sickness Synthesis of 2-hydrazolyl-4-thiazolidinones based on multicomponent reactions and biological evaluation against T. Cruzi Synthesis and structureeactivity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain Design, synthesis, and evaluation of 2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents Synthesis and anti-HIV studies of 2-adamantyl-substituted thiazolidin-4-ones Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents Design and synthesis of 2-(2,6-dibromophenyl)-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents Predicting anti-HIV activity of 1,3,4-thiazolidinone derivatives: 3D-QSAR approach Design, microwave-assisted synthesis and HIV-RT inhibitory activity of 2-(2,6-dihalophenyl)-3-(4,6-dimethyl-5-(un)substituted-pyrimidin-2-yl)thiazolidin-4-ones Non-nucleoside inhibitors of the hepatitis C virus NS5B RNA-dependant RNA polymerase: 2-aryl-3-heteroaryl-1,3-thiazolidin-4-one derivatives Synthesis and biological activity of 4-(3-aryl-4-oxo-2-thioxothiazolidin-5-ylimino)-3-methyl-1-(N,N-disubstituted aminomethyl) pyrazolin-5-ones Synthesis and antiviral activity of new pyrazole and thiazole derivatives Synthesis and anticancer and antiviral activities of new 2-pyrazoline-substituted 4-thiazolidinones Synthesis and antidepressant activities of some 3,5-diphenyl-2-pyrazolines Synthesis and antihyperglycemic activity of novel 5-(naphthalenylsulfonyl)-2,4-thiazolidinediones Synthesis and in vitro anticancer activity of 2,4-azolidinedione-acetic acids derivatives Structureeanticancer activity relationships among 4-azolidinone-3-carboxylic acids derivatives Synthesis and evaluation of antitumor activity of 5-[2-(3,5-diaryl-4,5-dihydropyrazol-1-yl)-2-oxoethylidene Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines Some practical considerations and applications of the national cancer institute in vitro anticancer drug discovery screen Cancer Drug Discovery and Development The NCI60 human tumour cell line anticancer drug screen Synthesis and anticancer activity of novel nonfused bicyclic thiazolidinone derivatives, Phosphorus New 5-arylidene-4-thiazolidinones and their anticancer activity A facile synthesis and anticancer activity evaluation of spiro Thiazolidinone motif in anticancer drug discovery. Experience of DH LNMU medicinal chemistry scientific group Synthesis and anticancer activity evaluation of 4-thiazolidinones containing benzothiazole moiety Synthesis and anticancer activity of isatin-based pyrazolines and thiazolidines conjugates Synthesis and antitumor activity of novel 2-thioxo-4-thiazolidinones with benzothiazole moieties Synthesis of new 4ethiazolidinone-, pyrazoline-, and isatin-based conjugates with promising antitumor activity Study of molecular mechanisms of proapoptotic action of novel heterocyclic 4-thiazolidone derivatives In vitro and in vivo assay systems for study of influenza virus inhibitors keywords: activity; anticancer; cell; compounds; concentration; drug; growth; synthesis cache: cord-252108-04xr5xdl.txt plain text: cord-252108-04xr5xdl.txt item: #35 of 112 id: cord-253276-mqcwk2ow author: Desai, N. C. title: Synthesis, antimicrobial and cytotoxic activities of some novel thiazole clubbed 1,3,4-oxadiazoles date: 2013-09-30 words: 2670 flesch: 45 summary: Further, the results of preliminary MTT cytotoxicity studies on HeLa cells suggested that potent antimicrobial activity of 5b, 5c, 5f, 5h and 5i is accompanied by low cytotoxicity. The role of electron withdrawing group in improving antimicrobial activity is very well supported by previous studies [41, 42] . keywords: activity; antibacterial; compounds; para; position; ring; secondary cache: cord-253276-mqcwk2ow.txt plain text: cord-253276-mqcwk2ow.txt item: #36 of 112 id: cord-256992-rwy0n01l author: Taheri, Yasaman title: Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications date: 2020-08-01 words: 7288 flesch: 31 summary: Myricetin antidiabetic activity has been reported by several authors in the last few years and limited reports are also available on its anti-obesity activity but in this review, we focused on only its antidiabetic potential. Thus, this review provides new insights on myricetin preclinical pharmacological activities, and role in selected clinical trials. keywords: activities; activity; antioxidant; cancer; cells; compound; effects; flavonoids; glucose; human; inhibition; model; myricetin; potential; rats; studies; study; vitro; vivo cache: cord-256992-rwy0n01l.txt plain text: cord-256992-rwy0n01l.txt item: #37 of 112 id: cord-257167-rz4r5sj7 author: None title: Abstracts for the 29th Annual Meeting of the Japan Neuroscience Society (Neuroscience2006) date: 2006-12-31 words: 241480 flesch: 43 summary: Inst., Kyoto Univ., Inuyama, Japan GABAergic cells in the cerebral cortex are divided into subgroups: parvalbumin (PV)-, somatostatin (SOM)-, calretinin (CR)-, and calbindin-containing types. In the present study, we therefore investigated the synthesis of sex steroids and corticosteroids in the hippocampus of adult male rats, by monitoring the metabolism of tritiated steroids with HPLC system. PS2A-G125 GABA depolarizes GnRH neurons isolated from adult GnRH-EGFP transgenic rats Chengzhu Yin, Nobuyuki Tanaka, Masakatsu Kato, Yasuo Sakuma Nippon Medical School, Department of physiology, Tokyo, Japan GnRH neurons are essential in the reproductive neuroendocrine system. keywords: 1,2; 100; acid; action; activation; activities; activity; addition; administration; adult; age; amplitude; amygdala; analysis; animals; antagonist; application; area; astrocytes; auditory; axons; bdnf; behavioral; binding; biology; body; brain; brain activity; brain development; brain function; brain research; brain science; bsi; ca1; calcium; camkii; cells; cellular; center; central; cerebellar; cerebral; changes; channel; chiba; cns; cognitive; complex; condition; contrast; control; correlation; cortex; cortex neurons; cortical; crest; cultured; current; data; days; death; decrease; dendrites; dendritic; department; dept; development; difference; differentiation; direction; disease; disorders; distribution; div; division; domain; dopamine; dopaminergic; dorsal; dynamics; effect; estrogen; evoked; excitatory; experiments; exposure; expression; eye; factors; family; fibers; field; findings; firing; fmri; following; formation; fos; frequency; function; funds; gaba; gabaergic; gene; gene expression; gfp; glutamate; gnrh neurons; graduate; granule; group; growth; gyrus; hand; health; high; hippocampal neurons; hippocampus; hiroshi; human; imaging; increase; individual; induced; induction; inhibition; inhibitory; injection; injury; inputs; institute; interaction; interneurons; intracellular; involvement; japan; japan brain; japan neural; japan neurons; japan science; jst; kakenhi; kinase; kyoto; kyoto university; lab; laboratory; layer; learning; left; level; life; like; localization; loss; ltd; ltp; male; manner; mechanisms; med; medical; medicine; membrane; memory; method; mice; microglia; migration; model; molecular; molecules; monkeys; motion; motor; motor neurons; mouse; mouse brain; movement; mrna; multiple; muscle; mutant; nagoya; national; nerve; nervous; network; neural; neurite; neuronal; neurons; neuroscience; new; nmda; non; novel; nuclei; nucleus; number; olfactory; onset; order; osaka; osaka university; pain; pathway; patients; pattern; period; phase; phosphorylation; physiology; plasticity; play; postnatal; postsynaptic; potential; prefrontal; presence; present; presynaptic; primary; process; processes; processing; progenitor cells; projection neurons; proliferation; properties; protein; ps2p; ps3a; ps3p; purkinje cells; pyramidal; rat brain; rate; rats; receptor; recorded; recording; reduced; region; regulation; relationship; release; report; required; research; research funds; research institute; response; results; reward; right; riken; role; saitama; school; sciences; second; selective; sensory; signaling; signals; site; size; slices; social; specific; spike; spinal; spines; state; stem cells; stimulation; stimuli; stimulus; stress; structure; studies; study; subjects; surface; synapses; synaptic; system; target; task; technology; temporal; term; terminals; test; time; tohoku; tokyo; tokyo university; transcription; transgenic; transmission; treatment; tsukuba; type; university; university graduate; university school; usa; visual; vitro; vivo; voltage; weeks; wild; zone cache: cord-257167-rz4r5sj7.txt plain text: cord-257167-rz4r5sj7.txt item: #38 of 112 id: cord-257494-242k58ll author: Bastos, Paulo title: Human Antimicrobial Peptides in Bodily Fluids: Current Knowledge and Therapeutic Perspectives in the Postantibiotic Era date: 2017-01-17 words: 17385 flesch: 26 summary: A new skin-specific proteinase inhibitor that is a target for crosslinking by transglutaminase Peptide hormones and their analogues: Distribution, clearance from the circulation, and inactivation in vivo Discovery of JANUVIA (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes Human antimicrobial peptides and proteins Antimicrobial peptides: Properties and applicability Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles Human antimicrobial peptides (AMPs) represent approximately 10% of all curated AMPs catalogued to date. keywords: abps; acids; action; activity; amino; amps; aureus; bacteria; cationic; cells; coli; defensins; fluids; gram; histatin; host; human; identification; infection; ll-37; membrane; novel; peptides; plasma; properties; protein; residues; resistance; salivary; species; structure cache: cord-257494-242k58ll.txt plain text: cord-257494-242k58ll.txt item: #39 of 112 id: cord-257749-eyhsc8q8 author: Koul, Bhupendra title: Genus Psoralea: A review of the traditional and modern uses, phytochemistry and pharmacology date: 2019-03-25 words: 11106 flesch: 33 summary: cytotoxicity of bakuchiol and the analogues Gamma radiation effects on growth and yield attributes of Psoralea corylifolia L. with reference to enhanced production of psoralen Review of constituents in fruits of Psoralea corylifolia L Anti-oxidants from a Chinese medicinal herb-Psoralia corylifolia L Induction of apoptosis in human hepatocarcinoma SMMC-7721 cells in vitro by psoralen from Psoralea corylifolia Isopsoralen from the seeds of Psoralea corylifolia L Chemical examination of the seeds of Psoralea corylifolia New Delhi, Oxford and IBH Publishing Co Pvt Ltd; Medicinal Plants In vivo anti-diabetic and anti-oxidant potential of Psoralea corylifolia seeds in Streptozotocin induced type-2 diabetic rats Handbook of Ayurvedic Medicinal Plants In vitro antimicrobial activities of bakuchiol against oral microorganisms Kinetics of the anti-staphylococcal activity of bakuchiol in vitro The Psoralea food resource of northern plains Daidzin: a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase Anti-oxidant, hemolytic and mutagenic potential of Psoralea corylifolia Encyclopedia of Indian Medicinal Plants Anti-bacterial compounds from the seeds of Psoralea corylifolia Pesticidal activity of a novel coumestan derivative isolated from Psoralea corylifolia L. against Tribolium casteneum Herbst adults and larvae Psoralea corylfolia Experimental and theoretical studies The botany, chemistry pharmacological and therapeutic application of Psoralea corylifolia L -a review A Dictionary of Plants Used by Man Osteoblastic proliferation stimulating activity of Psoralea corylifolia extracts and two of its flavonoids Experimental study on the effect of fructus lyc II and 7 other Chinese drugs on cells cultured in vitro and macrophages of the abdominal cavity in mice Furocoumarins affect hepatic cytochrome P450 and renal organic ion transporters in mice Identification and characterization of naturally occurring inhibitors against UDP-glucuronosyltransferase 1A1 in Fructus psoraleae (Bugu-zhi) Synergistic effect of psoralen cooperated with substrates on tyrosinase activation Screening anti-tumor compounds psoralen and isopsoralen from Psoralea corylifolia L. seeds. keywords: activity; anti; bakuchiol; cancer; cells; compounds; constituents; corylifolia; effect; et al; extract; fructus; human; isopsoralen; new; plants; potential; properties; psoralea; psoralea corylifolia; psoralidin; roots; seeds; species; studies; study; treatment; tumor; vitro cache: cord-257749-eyhsc8q8.txt plain text: cord-257749-eyhsc8q8.txt item: #40 of 112 id: cord-258239-7xyqlz0u author: Gärtner, Fabian title: Application of an Activity-Based Probe to Determine Proteolytic Activity of Cell Surface Cathepsin G by Mass Cytometry Data Acquisition date: 2020-10-19 words: 2568 flesch: 40 summary: Cell surface CatG on neutrophils is still proteolytically active, 11 although natural serine protease inhibitors, including α 1 -antitrypsin, are present at the site of inflammation but cannot inhibit cell surface CatG. First, neutrophils release matrix metalloproteases in order to proteolytically inactivate α 1 -antitrypsin, 12 and second, the bulky natural serine protease inhibitor, α 1 -proteinase inhibitor might not be able to reach the catalytic center of cell surfacebound CatG by steric hindrance. We applied the activity-based probe MARS116-Bt to mass cytometry by time-of-flight to analyze CatG activity on the cell surface of immune cells. keywords: activity; catg; cell; mars116; neutrophils; surface cache: cord-258239-7xyqlz0u.txt plain text: cord-258239-7xyqlz0u.txt item: #41 of 112 id: cord-260674-a0ejus6m author: Chopra, Sakshi title: Impact of COVID-19 on lifestyle-related behaviours- a cross-sectional audit of responses from nine hundred and ninety-five participants from India date: 2020-10-06 words: 4291 flesch: 41 summary: The questionnaire has three sections assessing socio-demographic details, changes in lifestyle related behaviour and COVID specific reasons for the changes in these behaviors. The comparison of mean scores of lifestyle related behaviours before and during COVID-19 is shown in Table 3 . keywords: activity; changes; covid-19; eating; food; lifestyle; participants; study cache: cord-260674-a0ejus6m.txt plain text: cord-260674-a0ejus6m.txt item: #42 of 112 id: cord-261170-arnwk287 author: Gallimore, W. title: Chapter 18 Marine Metabolites Oceans of Opportunity date: 2017-12-31 words: 7131 flesch: 37 summary: There are several marine compounds sourced from microbes which are of clinical significance. Trends in the discovery of new marine natural products from invertebrates over the last two decades À Where and what are we bioprospecting? keywords: activity; agents; alga; cancer; cell; compounds; cytotoxic; drug; evaluation; marine; metabolites; new; organisms; phase; potential; products; range; species; sponge; trials cache: cord-261170-arnwk287.txt plain text: cord-261170-arnwk287.txt item: #43 of 112 id: cord-262950-zv6qerhg author: Reinert, Kassidy S. title: Creating Digital Activity Schedules to Promote Independence and Engagement date: 2020-06-19 words: 5785 flesch: 67 summary: Although the majority of research studies demonstrating the effectiveness of activity schedules have used schedule books composed of static printed pictures attached to physical pages, recently researchers have begun to demonstrate the effectiveness of technology-based activity schedules. These studies demonstrate that activity schedules promote independence, increase learner engagement with appropriate activities, and decrease reliance on prompts. keywords: activity; arrow; click; fig; navigation; page; schedule; slide cache: cord-262950-zv6qerhg.txt plain text: cord-262950-zv6qerhg.txt item: #44 of 112 id: cord-265764-h4zg0q8x author: Singh, Kamaljit title: Synthesis of 4-aminoquinoline–pyrimidine hybrids as potent antimalarials and their mode of action studies date: 2013-06-10 words: 4128 flesch: 42 summary: [27] and antimalarial activities Recently, antimalarial activities of some quinolineepyrimidine hybrids with activities in the micromolar to nanomolar range have been reported (Fig. 3) keywords: activity; antimalarial; cell; compounds; dna; heme; hybrids; synthesis; table; virus cache: cord-265764-h4zg0q8x.txt plain text: cord-265764-h4zg0q8x.txt item: #45 of 112 id: cord-267284-3uz0v29k author: Schneiderová, Kristýna title: Phytochemical profile of Paulownia tomentosa (Thunb). Steud. date: 2014-08-29 words: 8607 flesch: 27 summary: In some cases, no specific biological activity has been observed (Kim et al. 2010a (Kim et al. , 2010b Tang et al. 1994) . It has neuroprotective effects against glutamate-induced neurotoxicity (Kim et al. 2010a (Kim et al. , 2010b and cytotoxic activity against several cancer cell lines: A549 lung carcinoma; SK-OV-3 adenocarcinoma; SK-Mel-2 malignant melanoma; XF498 central nervous system tumors; HCT15 colon adenocarcinoma, against which its effect is comparable to that of reference substance adriamycin (Moon and Zee 2001) ; human breast cancers MDA-MB-231, MCF7, HS578T, and T47D; and the HeLa, SiHa and C33A cervical cancer cell lines (Jung et al. 2012) . keywords: acid; activities; activity; anti; antioxidant; cancer; cells; compounds; cytotoxic; effects; et al; flavonoids; flowers; glycosides; human; inhibition; inhibitory; leaves; paulownia; plant; rats; structure; tomentosa cache: cord-267284-3uz0v29k.txt plain text: cord-267284-3uz0v29k.txt item: #46 of 112 id: cord-269943-g77qe5ml author: Di Sotto, Antonella title: Plant-Derived Nutraceuticals and Immune System Modulation: An Evidence-Based Overview date: 2020-08-22 words: 13975 flesch: 28 summary: Accordingly, oleic acid is classified as a ω-9 (or n-9) fatty acid, while linoleic acid and α-linolenic acid are ω-6 (or n-6) and ω-3 (or n-3) fatty acids, as they contain the double bond nine, six and three carbons from the methyl end The role of fatty acid structure, metabolism, and possible second messenger systems Minerval induces apoptosis in Jurkat and other cancer cells Comparative toxicity of oleic acid and linoleic acid on Jurkat cells Comparative toxicity of oleic acid and linoleic acid on Raji cells Oleate protects macrophages from palmitate-induced apoptosis through the downregulation of CD36 expression Oleate but not stearate induces the regulatory phenotype of myeloid suppressor cells Skin-Specific Unsaturated Fatty Acids Boost the Staphylococcus aureus Innate Immune Response Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents Modulation of peroxisome proliferator-activated receptor gamma(PPAR γ) by conjugated fatty acid in obesity and inflammatory bowel disease Punicic acid a conjugated linolenic acid inhibits TNFalpha-induced neutrophil hyperactivation and protects from experimental colon inflammation in rats Role of omega-3 fatty acids in obesity, metabolic syndrome, and cardiovascular diseases: A review of the evidence Polyunsaturated fatty acids and inflammation Long-chain polyunsaturated fatty acids regulation of PPARs, signaling: Relationship to tissue development and aging Dietary Bioactive Fatty Acids as Modulators of Immune Function: Implications on Human Health Impact of Omega-3 Fatty Acids on the Gut Microbiota Linseed Essential Oil-Source of Lipids as Active Ingredients for Pharmaceuticals and Nutraceuticals The chemical composition, botanical characteristic and biological activities of Borago officinalis: A review. keywords: acid; activation; activity; anti; astragalus; cancer; cells; chain; effects; fatty; function; glucan; immune; immunity; immunomodulatory; inflammation; labdane; levels; macrophages; oil; plant; polysaccharides; production; properties; pufa; response; studies; system; ω-3 cache: cord-269943-g77qe5ml.txt plain text: cord-269943-g77qe5ml.txt item: #47 of 112 id: cord-270037-tq82srhn author: Kramer, Holger B. title: Detection of ubiquitin–proteasome enzymatic activities in cells: Application of activity-based probes to inhibitor development() date: 2012-05-19 words: 5718 flesch: 32 summary: The last two decades have witnessed the development and application of activity based probes for the detection of enzymatic activities related to a wide range of protein post-translational modifications (PTMs). The generation of activity based probes for the ubiquitin pathway as important tools to obtain insights into the ubiquitin proteasome system has been reviewed previously keywords: activity; cell; development; dub; dubs; enzyme; inhibition; inhibitors; kinase; labeling; probes; proteasome; protein; ubiquitin cache: cord-270037-tq82srhn.txt plain text: cord-270037-tq82srhn.txt item: #48 of 112 id: cord-270424-8yhsjbmi author: Kang, Dongwei title: First discovery of novel 3-hydroxy-quinazoline-2,4(1H,3H)-diones as specific anti-vaccinia and adenovirus agents via ‘privileged scaffold’ refining approach date: 2016-11-01 words: 1928 flesch: 35 summary: The biological significance of the novel synthesized quinazolines was highlighted by evaluating them in vitro for antiviral activity, wherein several compounds exhibited excellent activity specifically against vaccinia and adenovirus. To the best of our knowledge, no data are present in the literature on antiviral activity of 3-hydroxy-quinazoline-2,4(1H,3H)-diones against DNA-viruses. keywords: activity; adenovirus; compounds; infections; smallpox; vaccinia cache: cord-270424-8yhsjbmi.txt plain text: cord-270424-8yhsjbmi.txt item: #49 of 112 id: cord-270602-599vweqe author: Donia, Marwa title: Marine natural products and their potential applications as anti-infective agents date: 2003-05-22 words: 5970 flesch: 32 summary: key: cord-270602-599vweqe authors: Donia, Marwa; Hamann, Mark T title: Marine natural products and their potential applications as anti-infective agents date: 2003-05-22 journal: Lancet Infect Dis DOI: 10.1016/s1473-3099(03)00655-8 sha: doc_id: 270602 cord_uid: 599vweqe The oceans are a unique resource that provide a diverse array of natural products, primarily from invertebrates such as sponges, tunicates, bryozoans, and molluscs, and from marine bacteria and cyanobacteria. Furthermore, there are some excellent general and extensive reviews focusing on marine natural products, such as those by Capon, 12 Newman and colleagues, 13 and Faulkner. keywords: activity; agents; antifungal; antiviral; clinical; diseases; drug; effects; leads; manzamine; marine; mic; products; sponge cache: cord-270602-599vweqe.txt plain text: cord-270602-599vweqe.txt item: #50 of 112 id: cord-270892-ycc3csyh author: Rollinger, Judith M. title: The human rhinovirus: human‐pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery date: 2010-12-13 words: 19699 flesch: 35 summary: if by hand How contagious are common respiratory tract infections? Environmental contamination with rhinovirus and transfer to fingers of healthy individuals by daily life activity Aerosol transmission of rhinovirus colds Hand-to-hand transmission of rhinovirus colds Transmission of experimental rhinovirus infection by contaminated surfaces Interruption of experimental rhinovirus transmission Virucidal activity and cytotoxicity of the liposomal formulation of povidone-iodine Virucidal hand treatments for prevention of rhinovirus infection Localization of human rhinovirus replication in the upper respiratory tract by in situ hybridization Experimental rhinovirus infection in volunteers Detection of rhinovirus RNA in lower airway cells during experimentally induced infection Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection Histopathologic examination and enumeration of polymorphonuclear leukocytes in the nasal mucosa during experimental rhinovirus colds Sites of rhinovirus recovery after point inoculation of the upper airway Incubation periods of experimental rhinovirus infection and illness Quantitative and qualitative analysis of rhinovirus infection in bronchial tissues Rhinoviruses infect the lower airways Incidence and characteristics of viral community-acquired pneumonia in adults Etiology of community-acquired pneumonia in 254 hospitalized children Improved diagnosis of the etiology of community-acquired pneumonia with real-time polymerase chain reaction Etiology of community-acquired pneumonia in hospitalized school-age children: Evidence for high prevalence of viral infections Association between interleukin-8 concentration in nasal secretions and severity of symptoms of experimental rhinovirus colds Symptom profile of common colds in schoolaged children The microbial etiology and antimicrobial therapy of adults with acute community-acquired sinusitis: A fifteen-year experience at the University of Virginia and review of other selected studies Bacterial coinfections in children with viral wheezing Amplified rhinovirus colds in atopic subjects Experimental rhinovirus 16 infection potentiates histamine release after antigen bronchoprovocation in allergic subjects Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects The effects of rhinovirus infections on allergic airway responses Rhinovirus upper respiratory infection increases airway hyperreactivity and late asthmatic reactions An experimental model of rhinovirus induced chronic obstructive pulmonary disease exacerbations: A pilot study Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production The economic burden of non-influenzarelated viral respiratory tract infection in the United States Rhinovirus chemotherapy Excessive antibiotic use for acute respiratory infections in the United States Influenza virus and rhinovirus-related otitis media: Potential for antiviral intervention The viruses and their replication Analysis of the structure of a common cold virus, human rhinovirus 14, refined at a resolution of 3.0 A The refined structure of human rhinovirus 16 at 2.15 A resolution: Implications for the viral life cycle Crystal structure of human rhinovirus serotype 1A (HRV1A) 1. Effect of shape on binding of steroids to carrier proteins Investigation on QSAR and binding mode of a new class of human rhinovirus-14 inhibitors by CoMFA and docking experiments Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus CoMFA analysis of the interactions of antipicornavirus compounds in the binding pocket of human rhinovirus-14 dihydro-2-oxazolyl)phenoxy]alkyl]-3-methylisoxazoles: Inhibitors of picornavirus uncoating Understanding human rhinovirus infections in terms of QSAR Site-directed mutagenesis suggests close functional relationship between a human rhinovirus 3C cysteine protease and cellular trypsin-like serine proteases The picornaviral 3C proteinases: Cysteine nucleophiles in serine proteinase folds Substituted benzamide inhibitors of human rhinovirus 3C protease: Structure-based design, synthesis, and biological evaluation Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. keywords: activity; agents; antiviral; binding; capsid; cells; cold; compounds; discovery; drug; echinacea; effect; efficacy; fig; group; hrv; human; infection; inhibitors; protease; protein; receptor; replication; results; rhinovirus; rhinovirus infection; rna; serotypes; structure; studies; study; synthesis; table; treatment cache: cord-270892-ycc3csyh.txt plain text: cord-270892-ycc3csyh.txt item: #51 of 112 id: cord-271068-rwx171oj author: Mayer, Alejandro M.S. title: Marine pharmacology in 2007–8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action date: 2010-09-03 words: 10066 flesch: 8 summary: During 2007-8, 38 studies reported novel antibacterial marine natural products isolated from marine bacteria, fungi, sponges, worms and fish, a larger effort than the ones reported in previous years (Mayer et al., 2009) , and previous reviews of this series. Four articles published during 2007-8, reported anticoagulant marine natural products isolated from algae and clams, a number very similar to that reported in our previous review (Mayer et al., 2009) , and other reviews of this marine pharmacology series. keywords: acid; action; activity; alga; antibacterial; anticoagulant; antifungal; brown; cells; compounds; et al; marine; mayer; mic; new; novel; pharmacology; products; red; sea; sponge; table cache: cord-271068-rwx171oj.txt plain text: cord-271068-rwx171oj.txt item: #52 of 112 id: cord-272943-q09i8fqu author: Dalhoff, A. title: Antiviral, antifungal, and antiparasitic activities of fluoroquinolones optimized for treatment of bacterial infections: a puzzling paradox or a logical consequence of their mode of action? date: 2014-12-17 words: 4721 flesch: 33 summary: Although the complexity and diversity of prokaryotic and eukaryotic topoisomerases is remarkable and little or no sequence homology of amino acids exists, type I and type II topoisomerases share certain structural elements mediating identical functions like DNA relaxation or DNA transport in bacteria, DNA viruses, yeasts, and parasites; the DNA helicase coordinates the directionality of topoisomerase activity; RNA helicases as present, e.g., in hepatitis C virus (HCV) directly interact with double-stranded DNA or RNA and assembles complexes with type II topoisomerases [49] [69] inhibited viral topoisomerase activity of vaccinia virus but not of herpes simplex virus and influenza virus keywords: activities; activity; antifungal; chloroquine; ciprofloxacin; dna; fluoroquinolones; infections; inhibition; topoisomerases cache: cord-272943-q09i8fqu.txt plain text: cord-272943-q09i8fqu.txt item: #53 of 112 id: cord-274101-vm9nh8lc author: Perez Espitia, Paula Judith title: Bioactive Peptides: Synthesis, Properties, and Applications in the Packaging and Preservation of Food date: 2012-02-29 words: 12728 flesch: 31 summary: Current EU approved additives and their E numbers Defensins: antimicrobial peptides of innate immunity Immunomodulatory peptides obtained by the enzymatic hydrolysis of whey proteins Principles of mass transfer Development of cellulose acetate-based antimicrobial food packaging materials for controlled release of lysozyme Polymer surface modification for the attachment of bioactive compounds Development and characterization of an antimicrobial packaging film coating containing nisin for inhibition of Listeria monocytogenes Antimicrobial plastic film: physico-chemical characterization and nisin desorption modeling Innovative multilayer antimicrobial films made with Nisaplin ® or nisin and cellulosic ethers: physico-chemical characterization, bioactivity and nisin desorption kinetics Simulating diffusion model and determining diffusivity of potassium sorbate through plastics to develop antimicrobial packaging films The role of cationic antimicrobial peptides in innate host defences Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies Antimicrobial activities of amphiphilic peptides covalently bonded to a water-insoluble resin A coating for use as an antimicrobial and antioxidative packaging material incorporating nisin and [alpha]-tocopherol Studies on anticancer activities of antimicrobial peptides The antibacterial activity of magainin I immobilized onto mixed thiols self-assembled monolayers Proteomics for studying cancer cells and the development of chemoresistance Antifungal properties and mode of action of psacotheasin, a novel knottin-type peptide derived from Psacothea hilaris Antifungal activity of synthetic peptide derived from halocidin, antimicrobial peptide from the tunicate, Halocynthia aurantium Peptide antimicrobial agents Chemical synthesis of peptides and proteins Properties of nisin-incorporated polymer coatings as antimicrobial packaging materials Bioactive peptides: production and functionality Thermal, mechanical and water vapor barrier properties of sodium caseinate films containing antimicrobials and their inhibitory action on Listeria monocytogenes Antifungal mechanism of SMAP-29 (1-18) isolated from sheep myeloid mRNA against Trichosporon beigelii Antitumor activity of the antimicrobial peptide magainin II against bladder cancer cell lines Virucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses Recombinant production of antimicrobial peptides in Escherichia coli: a review Peptide-derivatized dendrimers inhibit human cytomegalovirus infection by blocking virus binding to cell surface heparan sulfate Sínteses química e enzimática de peptídeos: princípios básicos e aplicações High-pressure processing and antimicrobial biodegradable packaging to control Listeria monocytogenes during storage of cooked ham Development and characterization of an active polyethylene film containing Lactobacillus curvatus CRL705 In animals, antimicrobial peptides are produced mainly in those tissues exposed to adverse conditions such as skin, eyes, and lungs, which are more likely to be in contact with microorganisms (Zasloff 2002; Papo and Shai 2003) . keywords: acid; activity; antimicrobial; cells; chemical; diffusion; film; food; formation; interaction; matrix; mechanism; membrane; methods; model; nisin; packaging; peptide; polymeric; process; properties; result; surface; synthesis; virus cache: cord-274101-vm9nh8lc.txt plain text: cord-274101-vm9nh8lc.txt item: #54 of 112 id: cord-274506-fzcuu4ma author: Jo, Seri title: Characteristics of flavonoids as potent MERS‐CoV 3C‐like protease inhibitors date: 2019-09-12 words: 4240 flesch: 46 summary: A F I G U R E 4 Comparison of inhibitory activity between homologue flavonoids. Among them, herbacetin (3,4′,5,7,8-Pentahydroxyflavone), isobavachalcone (2′,4,4′-Trihydroxy-3′-(3-methyl-2-butenyl)chalcone), quercetin 3-β-d-glucoside (3,3′,4′,5,7-Pentahydroxyflavone 3-β-d-glucoside) and helichrysetin (4,2′,4′-trihydroxy-6′methoxychalcone) were found to have prominent inhibitory activity (Figure 2 ). keywords: 3clpro; activity; binding; compounds; cov; flavonoids; fluorescence; mers; protease cache: cord-274506-fzcuu4ma.txt plain text: cord-274506-fzcuu4ma.txt item: #55 of 112 id: cord-276166-b1e0bbrp author: Li, Shi-fang title: Interferon-omega: Current status in clinical applications date: 2017-10-12 words: 7743 flesch: 41 summary: Type II IFN, namely IFN-γ, is produced by T lymphocytes and natural killer cells in response to the recognition of infected cells [5] . [19] Cattle Chromosome 8q15 The IFN-ω family in cattle (BoIFN-ω) consists of 24 members that contain two pseudogenes and 22 functional genes. keywords: activity; cats; cells; feline; human; ifn; interferon; omega; protein; rfeifn; studies; study; treatment; type; virus cache: cord-276166-b1e0bbrp.txt plain text: cord-276166-b1e0bbrp.txt item: #56 of 112 id: cord-277077-kwaiorp8 author: Tița, Ovidiu title: Use of Yoghurt Enhanced with Volatile Plant Oils Encapsulated in Sodium Alginate to Increase the Human Body’s Immunity in the Present Fight Against Stress date: 2020-10-19 words: 8120 flesch: 55 summary: According to various recent studies, volatile oils from various aromatic plants have a high content of antioxidants and antimicrobial compounds. The main purpose of this paper is to create a yoghurt with high antioxidant capacity, using only raw materials from Romania; (2) Methods: The bioactive components used to enrich the cow milk yoghurt were extracted as volatile oils out of four aromatic plants: basil, mint, lavender and fennel. keywords: 20th; antioxidant activity; basil; day; decline; fennel; lavender; milk; oil; oils; sodium; value; yoghurt sample cache: cord-277077-kwaiorp8.txt plain text: cord-277077-kwaiorp8.txt item: #57 of 112 id: cord-277541-ieex2xwx author: Sun, Jian title: Trypsin Isoinhibitors with Antiproliferative Activity toward Leukemia Cells from Phaseolus vulgaris cv “White Cloud Bean” date: 2010-06-14 words: 3595 flesch: 41 summary: The assay for HIV reverse transcriptase inhibitory activity was carried out in view of the report that trypsin inhibitors manifest this activity [50, 51] . Thus the purification procedure adopted in the present investigation can be conveniently used to separate trypsin inhibitors from antifungal proteins. keywords: activity; bean; cells; cloud; gel; inhibitor; protease; seeds; trypsin; white cache: cord-277541-ieex2xwx.txt plain text: cord-277541-ieex2xwx.txt item: #58 of 112 id: cord-277802-f8pyn3rx author: Roman, Gheorghe title: Mannich bases in medicinal chemistry and drug design date: 2015-01-07 words: 55399 flesch: 33 summary: Hybrid ligandalkylating agents targeting telomeric G-quadruplex structures Synthesis and biological activities of quinazoline derivatives with ortho-phenol-quaternary ammonium salt groups DNA binding, antiviral activities and cytotoxicity of new furochromone and benzofuran derivatives Synthesis and biological evaluation of 1,3-dihydroxyxanthone Mannich base derivatives as potential antitumor agents Synthesis and in vitro evaluation of novel indole-based sigma receptors ligands Synthesis and cytotoxic activity of novel 3-methyl-1-[(4-substituted-1-piperazinyl)methyl]-1H-indole derivatives Design, synthesis, and biological evaluation of indole-based 1,4-disubstituted piperazines as cytotoxic agents Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt) 3-Aminomethyl derivatives of 4,11-dihydroxynaphtho[2,3-f]indole-5,10-dione for circumvention of anticancer drug resistance Synthesis and structureeactivity relationship studies of Naphtho[2,3-f]indole-5,10-dione aminoalkyl derivatives: a new class of topoisomerase I inhibitors Synthesis of 4-substituted 3-[3-(dialkylaminomethyl)indol-1-yl]maleimides and study of their ability to inhibit protein kinase C-a, prevent development of multiple drug resistance of tumor cells and cytotoxicity Synthesis and SAR of novel 4-morpholinopyrrolopyrimidine derivatives as potent phosphatidylinositol 3-kinase inhibitors Cytotoxic and anticancer activities of isatin and its derivatives: a comprehensive review from Synthesis and in-vitro cytotoxicity evaluation of gatifloxacin Mannich bases Hybrid pharmacophore design and synthesis of isatinebenzothiazole analogs for their anti-breast cancer activity Synthesis of novel isatin-thiazoline and isatin-benzimidazole conjugates as anti-breast cancer agents Design and synthesis of anti-breast cancer agents from 4-piperazinylquinoline: a hybrid pharmacophore approach hydroxyphenyl)-3-substituted-2,3-dihydro-1,3,4-oxadiazole-2-thione derivatives: promising anticancer agents Synthesis of some novel 3,5-disubstituted 1,3,4-oxadiazole derivatives and anticancer activity on EAC animal model Synthesis, quantitative structure-activity relationship and biological evaluation of 1,3,4-oxadiazole derivatives possessing diphenylamine moiety as potential anticancer agents Synthesis, antitumor and antimicrobial activity of novel 1-substituted phenyl-3-[3-alkylamino(methyl)-2-thioxo-1,3,4-oxadiazol-5-yl]-b-carboline derivatives Synthesis and antitumor activity of fluoroquinolone C3-isostere derivatives: oxadiazole Mannich base derivatives Synthesis, characterization and in vitro cytotoxic properties of some new Schiff and Mannich bases in Hep G2 cells Design, synthesis and antitumor activities of fluoroquinolone C-3 heterocycles (IV): s-triazole SchiffeMannich bases derived from ofloxacin Facile synthesis and quantitative structureeactivity relationship study of antitumor active 2-(4-oxo-thiazolidin-2-ylidene)-3-oxo-propionitriles Synthesis and biological activity evaluation of 5-pyrazoline substituted 4-thiazolidinones Synthesis, Xray crystallographic analysis, and antitumor activity of N-(benzothiazole-2-yl)-1-(fluorophenyl)-O,O-dialkyl-a-aminophosphonates Synthesis and biological activities of aaminophosphonates derivatives containing thieno[3,2-c]pyridine (in Chinese) Synthesis, antimicrobial and anticancer activities of a novel series of diphenyl 1-(pyridin-3-yl) ethylphosphonates Design and one-pot synthesis of a-aminophosphonates and bis(aaminophosphonates) by iron(III) chloride and cytotoxic activity Synthesis, antiproliferative activity in cancer cells and theoretical studies of novel 6a,7b-dihydroxyvouacapan-17b-oic acid Mannich base derivatives Synthesis and anti-tumor activities of novel Synthesis and cytotoxicity studies of novel Dimethylamino-functionalised and N-heteroaryl-substituted titanocene anticancer drugs: synthesis and cytotoxicity studies Synthesis and cytotoxicity studies of new dimethylamino-functionalised and indolylsubstituted titanocene anti-cancer drugs Synthesis and cytotoxicity studies of new dimethylamino-functionalized and azolesubstituted titanocene anticancer drugs Synthesis and preliminary cytotoxicity studies of achiral indolyl-substituted titanocenes Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives Synthesis of antitumoractive betulinic acid-derived hydroxypropargylamines by copper-catalyzed Mannich reactions Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis Doxoform and Daunoform: anthracyclineformaldehyde conjugates toxic to resistant tumor cells Doxsaliform: a novel N-Mannich base prodrug of a doxorubicin formaldehyde conjugate Design, synthesis, and biological evaluation of doxorubicin-formaldehyde conjugates targeted to breast cancer cells Antiestrogen binding site and estrogen receptor mediate uptake and distribution of 4-hydroxytamoxifen-targeted doxorubicin-formaldehyde conjugate in breast cancer cells Rational design and synthesis of androgen receptortargeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin-formaldehyde conjugate Studies of targeting and intracellular trafficking of an anti-androgen doxorubicin-formaldehyde conjugate in PC-3 prostate cancer cells bearing androgen receptor-GFP chimera Doxorubicin-formaldehyde conjugates targeting a v b 3 integrin Poly (ethylene glycol) prodrug for anthracyclines via N-Mannich base linker: design, synthesis and biological evaluation Synthesis and invitro antitumor activities of some Mannich bases of 9-alkyl-1,2,3,4-tetrahydrocarbazole-1-ones Synthesis and biological evaluation of novel Mannich bases of 2-arylimidazo [2,1-b]benzothiazoles as potential anti-cancer agents Cytotoxic Mannich bases of 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones New synthetic chalcones: cytotoxic Mannich bases of 6-(4-chlorocinnamoyl)-2(3H)-benzoxazolone Synthesis and cytotoxicity of novel hexahydrothieno-cycloheptapyridazinone derivatives Synthesis and antibacterial study of unsaturated Mannich ketones Synthesis and antibacterial activity of fused Mannich ketones Novel Mannich ketones of oxazolidinones as antibacterial agents Synthesis and biological evaluation of a novel series of 2,2-bisaminomethylated aurone analogues as anti-inflammatory and antimicrobial agents Evaluation of antimicrobial activities of several Mannich bases and their derivatives Synthesis and biological evaluation of aminoketones Highly efficient one-pot synthesis, antimicrobial and docking studies of newer b-amino carbonyl derivatives catalyzed by silica sulfuric acid Synthesis of b-amino carbonyl derivatives of coumarin and benzofuran and evaluation of their biological activity Vuki cevi c, Antibacterial 3-(arylamino)-1-ferrocenylpropan-1-ones: synthesis, spectral, electrochemical and structural characterization Synthesis and characterization of some Mannich bases as potential antimicrobial agents Synthesis, characterization and antimicrobial evaluation of copper(II) complexes of 5-tert-butyl-pyrocatechin-derived Mannich bases Synthesis and microbiological evaluation of Mannich bases derived from 4,6-diacetylresorcinol Mannich reaction derivatives of novobiocin with modulated physiochemical properties and their antibacterial activities Novel aminonaphthoquinone Mannich bases derived from lawsone and their copper(II) complexes: synthesis, characterization and antibacterial activity Synthesis, antiinflammatory and antimicrobial activity of some new 1-(3-phenyl-3,4-dihydro-2H-1,3-benzoxazin-6-yl)ethanone derivatives An eco-friendly synthesis and antimicrobial activities of dihydro-2H-benzo-and naphtho-1,3-oxazine derivatives Synthesis and antibacterial evaluation of benzazoles tethered dihydro[1,3]oxazines ]oxazine derivatives catalyzed by zirconyl chloride and evaluation of its biological activities Biocidal activity of some Mannich base cationic derivatives Some electrophilic substitution reactions on 1-substituted-3-acetyl/carbethoxy-5-hydroxy-2-methylindole and the antimicrobial activity of these new indole derivatives Mannich base derivatives of 3-hydroxy-6-methyl-4H-pyran-4-one with antimicrobial activity A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities Synthesis and biological activities of new Mannich bases of chlorokojic acid derivatives Design, synthesis and in vivo/ in vitro screening of novel chlorokojic acid derivatives Mannich bases of 7-piperazinylquinolones and kojic acid derivatives: synthesis, in vitro antibacterial activity and in silico study Synthesis and antimicrobial screening of novel Mannich bases of isatin derivative Synthesis and antimicrobial evaluation of some novel trisubstituted s-triazine derivatives based on isatinimino, sulphonamido and azacarbazole Synthesis and antimicrobial screening of certain novel Mannich bases bearing 1,8-naphthyridine moiety Synthesis and antimicrobial activities of oxadiazoles, phthalazines and indolinones Synthesis and antimicrobial activity of Mannich bases of isatin and its derivatives with 2-[(2,6-dichlorophenyl) amino]phenylacetic acid Synthesis, antimicrobial screening and beta lactamase inhibitory activity of 3-(3-chloro-4-fluorophenylimino)indolin-2-one and 5-chloroindolin-2-one derivatives, Turk Synthesis, antiviral and antibacterial activities of isatin Mannich bases Synthesis and bioevaluation of Schiff and Mannich bases of isatin derivatives with 4-amino-5-benzyl-2,4-dihydro-3H-1,2,4-triazole-3-thione Synthesis, characterization and in vitro antimicrobial activity of some novel 5-substituted Schiff and Mannich base of isatin derivatives Synthesis and antimicrobial activity of novel 5-(1-adamantyl)-2-aminomethyl-4-substituted-1,2,4-triazoline-3-thiones Microbiologically active Mannich bases derived from 1,2,4-triazoles. keywords: acid; activities; activity; activity synthesis; addition; agents; amine; aminomethylation; analogues; antibacterial; anticonvulsant; antimycobacterial; binding; cancer; candidates; cell; comparable; compounds; cytotoxic; cytotoxic mannich; cytotoxicity; derivatives; derivatives synthesis; drug; evaluation; fig; good; group; human; inhibition; inhibitors; lines; mannich bases; mannich reaction; mic; mic ¼; moiety; novel; novel mannich; phenolic; position; potent; r ¼; reagents; receptor; reference; reference drug; ring; series; studies; study; synthesis; values; vitro; x ¼; ¼ ch; ¼ cl; ¼ h; ¼ n; ¼ o cache: cord-277802-f8pyn3rx.txt plain text: cord-277802-f8pyn3rx.txt item: #59 of 112 id: cord-278513-ajfpghze author: Boyle, John T. title: Demonstration of a difference in expression of maximal lactase and sucrase activity along the villus in the adult rat jejunum date: 1980-09-30 words: 3223 flesch: 42 summary: The more apical localization of lactase activity compared to sucrase activity on the crypt-villus unit may help to explain the vulnerability of this enzyme to acute mucosal injury (e.g., acute gastroenteritis). The data indicate that unlike sucrase activity, which is expressed maximally in enterocytes along the entire villus, maximal lactase activity is not attained until midvillus. keywords: activity; crypt; enzyme; lactase; sucrase; unit; villus cache: cord-278513-ajfpghze.txt plain text: cord-278513-ajfpghze.txt item: #60 of 112 id: cord-278654-dxx6z2fj author: Wysocki, Jan title: Reduced plasma ACE2 activity in dialysis patients: another piece in the conundrum of factors involved in hypertension and cardiovascular morbidity? date: 2013-06-19 words: 1779 flesch: 30 summary: key: cord-278654-dxx6z2fj authors: Wysocki, Jan; Batlle, Daniel title: Reduced plasma ACE2 activity in dialysis patients: another piece in the conundrum of factors involved in hypertension and cardiovascular morbidity? date: 2013-06-19 journal: Nephrology Dialysis Transplantation DOI: 10.1093/ndt/gft240 sha: doc_id: 278654 cord_uid: dxx6z2fj the reduction in plasma ACE2 activity reported in ESRD patients treated by dialysis, particularly in female subjects, could limit Ang II degradation leading to increased levels of this peptide, which could contribute to the high prevalence of hypertension and cardiovascular morbidity that afflicts the dialysis population predialysis patients with CKD or renal transplant patients. When compared with historic samples from healthy subjects, however, all CKD groups examined, i.e. predialysis, transplant patients and even subjects on dialysis, seemed to have increased levels of plasma ACE2 activity. keywords: ace2; activity; angiotensin; plasma cache: cord-278654-dxx6z2fj.txt plain text: cord-278654-dxx6z2fj.txt item: #61 of 112 id: cord-280795-wtrt13ij author: Han, Yu-Tsung title: Mutational analysis of a helicase motif-based RNA 5′-triphosphatase/NTPase from bamboo mosaic virus date: 2007-10-10 words: 5837 flesch: 43 summary: RNA 5′-triphosphatase activity of Nsp2 Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism Brome mosaic virus 1a nucleoside triphosphatase/helicase domain plays crucial roles in recruiting RNA replication templates RNA-stimulated NTPase activity associated with yellow fever virus NS3 protein expressed in bacteria Identification of the RNA-binding sites of the 28 kDa movement protein of bamboo mosaic potexvirus Structure of the hepatitis C virus RNA helicase domain This work was supported by grants, NSC 94-2752-B-005-012-PAE, from the National Science Council, Taiwan, Republic of China. In spite of lacking explicit biochemical data, the helicase-like domain of BaMV replicase has been thought to have RNA helicase activity, which may be required for resolving intramolecular base pairing in the template RNA and/or preventing the formation of extensive base pairing between template and the nascent complementary strand during RNA replication process. keywords: 5′-triphosphatase; activities; activity; bamv; domain; et al; helicase; motif; protein; rna; virus cache: cord-280795-wtrt13ij.txt plain text: cord-280795-wtrt13ij.txt item: #62 of 112 id: cord-281137-j81fgnld author: Rahman, Lubna title: An assessment on the role of endophytic microbes in the therapeutic potential of Fagonia indica date: 2017-08-01 words: 5283 flesch: 39 summary: Imbach before and after boiling Antioxidant activity and chemical constituents of edible flower of Sophora viciifolia Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E In vitro assessment of antioxidant potential and determination of polyphenolic compounds of Hedera nepalensis K. Koch Studies on products of browning reaction-antioxidative activities of products of browning reaction prepared from glucosamine Antioxidative, tyrosinase inhibiting and antibacterial activities of leaf extracts from medicinal ferns Antimicrobial and antiprotozoal activities of secondary metabolites from the fungus Eurotium repens An innovative microplate assay to facilitate the detection of antimicrobial activity in plant extracts Antimicrobial and antileishmanial activities of hypocrellins A and B Citrinin derivatives from the soil filamentous fungus Penicillium sp. H9318 Evaluation of actinomycete strains for key traits related with plant growth promotion and mycorrhiza helping activities From the editor: antioxidants and diseases of the brain Determination of in vitro antioxidant and radical scavenging activities of propofol Assessment of phenolic content and free radical-scavenging capacity of some Thai indigenous plants Investigation on the bioactivity of culturable endophytic and epiphytic bacteria associated with ethnomedicinal plants Total phenolic contents and free radical scavenging activity of certain Egyptian Ficus species leaf samples Free radical scavenging activity of an aqueous extract of potato peel A novel source of bioactive compounds: endophytic bacteria isolated from Centella asiatica Bioactive compound analysis and antioxidant activity of endophytic bacterial extract from Adhathoda beddomei Coumarins as antioxidants Isolation and characterization of endophytic bacterial flora from some Indian medicinal plants Isolation, characterization, and antimicrobial activity of endophytic bacteria from Polygonum cuspidatum The leishmaniases as model zoonoses Vector control in cutaneous leishmaniasis of the old world: a review of literature Extraction optimization of medicinally important metabolites from Datura innoxia Mill: an in vitro biological and phytochemical investigation Identifying protein kinase inhibitors using an assay based on inhibition of aerial hyphae formation in streptomyces Studies on the biosynthesis of surfactin, a lipopeptide antibiotic from Bacillus subtilis ATCC 21332 Values are mean ± SD of triplicate In the current study, endophytic bacterial crude extracts were screened for the inhibition of protein kinases with Streptomyces sp. keywords: activities; activity; antioxidant; bacteria; extracts; indica; inhibition; protein; radical; zone cache: cord-281137-j81fgnld.txt plain text: cord-281137-j81fgnld.txt item: #63 of 112 id: cord-281597-x53ni6q1 author: Chiasson, Melissa A title: Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact date: 2020-09-01 words: 10204 flesch: 48 summary: f80bb91 The Arg98Trp mutation in human VKORC1 causing VKCFD2 disrupts a di-arginine-based ER retention motif Warfarin and vitamin K compete for binding to Phe55 in human VKOR Mutational scanning reveals the determinants of protein insertion and association energetics in the plasma membrane Interplay between hydrophobicity and the positive-inside rule in determining membrane-protein topology Specificity in transmembrane helix-helix interactions can define a hierarchy of stability for sequence variants The power of multiplexed functional analysis of genetic variants Enzymatic assembly of DNA molecules up to several hundred kilobases Clinical and genetic determinants of warfarin pharmacokinetics and pharmacodynamics during treatment initiation Analysis of Large-Scale mutagenesis data to assess the impact of single amino acid substitutions Transmembrane Helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates r-VKORC1 expression in factor IX BHK cells increases the extent of factor IX carboxylation but is limited by saturation of another carboxylation component or by a shift in the rate-limiting step A cellular system for quantitation of vitamin K cycle activity: structure-activity effects on vitamin K antagonism by warfarin metabolites Altered Escherichia coli membrane protein assembly machinery allows proper membrane assembly of eukaryotic protein vitamin K epoxide reductase Recognition of transmembrane helices by the endoplasmic reticulum translocon Molecular code for transmembrane-helix recognition by the Sec61 translocon Protein targeting and degradation are coupled for elimination of mislocalized proteins Three-Dimensional Structures of Membrane Proteins from Genomic Sequencing The EVcouplings Python framework for coevolutionary sequence analysis A rapid, efficient, and economical inverse polymerase chain reaction-based method for generating a site saturation mutant library Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features Variation across human exomes and genomes reveals the spectrum of loss-of-function intolerance across human protein-coding genes Effect of the VKORC1 D36Y variant on warfarin dose requirement and pharmacogenetic dose prediction ClinVar: public archive of relationships among sequence variation and human phenotype Identification of the gene for vitamin K epoxide reductase Structure of a bacterial homologue of vitamin K epoxide reductase Structures of an intramembrane vitamin K epoxide reductase homolog reveal control mechanisms for electron transfer Rules for the recognition of dilysine retrieval motifs by coatomer Protein 3D structure computed from evolutionary sequence variation A platform for functional assessment of large variant libraries in mammalian cells Multiplex assessment of protein variant abundance by massively parallel sequencing An improved platform for functional assessment of large protein libraries in mammalian cells Substratemodulated unwinding of transmembrane helices in the NSS transporter LeuT Packing of apolar side chains enables accurate design of highly stable membrane proteins Fine-tuning the topology of a polytopic membrane protein: role of positively and negatively charged amino acids Mutations in the VKORC1 gene cause warfarin resistance, warfarin sensitivity and combined deficiency of vitamin K dependent coagulation factors An algorithm for managing warfarin resistance VKORC1 pharmacogenomics summary Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2 A statistical framework for analyzing deep mutational scanning data Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners A comprehensive comparison of transmembrane domains reveals organelle-specific properties Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer Stabilization of warfarin-binding pocket of VKORC1 and VKORL1 by a peripheral region determines their different sensitivity to warfarin inhibition AlignMe-a membrane protein sequence alignment web server Human Vitamin K Epoxide Reductase and its bacterial homologue have different membrane topologies and reaction mechanisms Evaluation of warfarin resistance using transcription activator-like effector nucleases-mediated vitamin K epoxide reductase knockout HEK293 cells Structured states of disordered proteins from genomic sequences A series of PDB-related databanks for everyday needs Amino acid distributions in integral membrane protein structures Control of topology and mode of assembly of a polytopic membrane protein by positively charged residues Warfarin and Vitamin K Epoxide reductase: a molecular accounting for observed inhibition The I-TASSER suite: protein structure and function prediction A novel functional VKORC1 promoter polymorphism is associated with inter-individual and interethnic differences in warfarin sensitivity Biochemical basis of hereditary resistance to warfarin in the rat We thank D Nickerson and M Dunham for helpful conversations in analyzing the data and writing the manuscript, A Leith of the UW Foege Flow Lab and D Prunkard of the UW Pathology Flow Cytometry Core Facility for assistance with cell sorting, and all members of the Fowler lab for helpful feedback on figures. Raw abundance scores were normalized such that WT-like variants had a score of one and total loss of abundance variants had a score of zero ( Figure 1c) . keywords: abundance; activity; cells; data; domain; egfp; et al; figure; library; positions; protein; scores; substitutions; transmembrane; variants; vitamin; vkor; warfarin cache: cord-281597-x53ni6q1.txt plain text: cord-281597-x53ni6q1.txt item: #64 of 112 id: cord-283301-adjjkqt2 author: Awolade, Paul title: Therapeutic significance of β-glucuronidase activity and its inhibitors: A review date: 2020-02-01 words: 19135 flesch: 30 summary: Taken together, these results partly suggest that ability to mimic D-glucuronic acid favours bGLU inhibitory activity. at 0.1, 0.2 or 0.3 mg/kg body weight/day, significantly reduced bacterial bGLU activity thereby suppressing 1,2-dimethylhydrazine (DMH)induced colon adenocarcinomas in a dose-dependent manner compared to DMH-controls. keywords: acid; activity; bacterial; bglu; bglu activity; bglu inhibitors; biomarker; cancer; catalytic; coli; compound; derivatives; disease; drug; enzyme; fig; fold; glucuronidase; human; inhibition; inhibitors; patients; periodontal; periodontitis; potency; potential; ring; sal; studies; study; synthesis; unit cache: cord-283301-adjjkqt2.txt plain text: cord-283301-adjjkqt2.txt item: #65 of 112 id: cord-285856-0sw3wt1i author: Naesens, Lieve title: Anti-influenza virus activity and structure–activity relationship of aglycoristocetin derivatives with cyclobutenedione carrying hydrophobic chains date: 2009-02-05 words: 2976 flesch: 27 summary: Additional anti-influenza virus compounds should be urgently developed, having a novel antiviral target that is highly conserved amongst influenza virus (sub)types and, hence, less prone to genetic variation and resistance selection. The cellular entry process of influenza viruses has been unraveled since many years (reviewed in Skehel and Wiley, 2000) . keywords: activity; aglycoristocetin; anti; glycopeptide; influenza; squaric; virus cache: cord-285856-0sw3wt1i.txt plain text: cord-285856-0sw3wt1i.txt item: #66 of 112 id: cord-286136-gm6w590s author: Aleksic Sabo, Verica title: Antimicrobial activity of Eucalyptus camaldulensis Dehn. plant extracts and essential oils: A review date: 2019-03-05 words: 11001 flesch: 28 summary: Asian Pac Antifungal effect of essential oil Eucalyptus camaldulensis plant on Fusarium graminearum and Fusarium sporotrichioide Multicenter collaborative trial of intravenous acyclovir for treatment of mucocutaneous herpes simplex virus infection in the immunocompromised host Preparation and characterization of liposomes containing essential oil of Eucalyptus camaldulensis leaf Chemical composition of essential oils of Eucalyptus from Benin: The most fungal model organisms are sensitive to 0.125–1.0% of E. camaldulensis essential oil. keywords: activities; activity; agents; antibacterial; antifungal; camaldulensis; chemical; cineole; composition; compounds; effect; eos; et al; eucalyptus; eucalyptus camaldulensis; extraction; extracts; leaf; leaves; methanol; oil; oils; plant; species; studies; virus cache: cord-286136-gm6w590s.txt plain text: cord-286136-gm6w590s.txt item: #67 of 112 id: cord-286303-wo6356vq author: Khanna, Varun title: Prediction of novel mouse TLR9 agonists using a random forest approach date: 2019-12-20 words: 6165 flesch: 52 summary: FP, false positivesthe total number of low activity ODNs incorrectly classified as high activity ODNs. FN, false negativesthe total number of high activity ODNs incorrectly classified as low activity ODNs. keywords: accuracy; activity; activity odns; dataset; features; model; motifs; mtlr9; mtlr9 activity; odns cache: cord-286303-wo6356vq.txt plain text: cord-286303-wo6356vq.txt item: #68 of 112 id: cord-287348-00yaxpkp author: Martinez, Maria Jose Abad title: Antiviral Activities of Polysaccharides from Natural Sources date: 2005-12-31 words: 7010 flesch: 43 summary: Although relatively little work has been done on natural antivirals against plant viruses, several reports concerning antiviral activity against plant virus infection have been recorded; for example, yeast mannans with antiviral activity against the tobacco mosaic virus infection in tobacco plants [136] , and lichenan PS from Iceland moss which exhibited antiviral activity against the potato viruses [8] . For example, different natural polymeric carbohydrates inhibited rabies virus infection in chicken-embryo-related cells by interfering with the virus adsorption process [126] . keywords: activity; agents; alga; antiviral; cell; compounds; extracts; hiv; infections; marine; plant; replication; sulphate; virus; viruses; vitro cache: cord-287348-00yaxpkp.txt plain text: cord-287348-00yaxpkp.txt item: #69 of 112 id: cord-291559-h6czy5bh author: Koirala, Prashamsa title: Recent advances in pharmacological research on Ecklonia species: a review date: 2017-08-24 words: 12291 flesch: 22 summary: Dieckol and PFF-A obtained from boiling water-and organic solvent extracts of EC and ES showed almost 9-and 7-fold stronger antioxidant activity than the standard butylhydroxytoluene, and 6-and 4-fold greater activity than l-ascorbic acid in molar concentration, Anti-inflammatory activity Ecklonia cava Dieckol Decreased blood glucose level Kang et al. Undaria pinnatifida and Ecklonia stolonifera Antibacterial activities of marine epibiotic bacteria isolated from brown algae of Japan Antioxidant and anti-inflammatory activities of ventol, a phlorotannin-rich natural agent derived from Ecklonia cava, and its effect on proteoglycan degradation in cartilage explant culture A new phlorotannin from the brown alga Ecklonia stolonifera Inhibitory phlorotannins from the edible brown alga Ecklonia stolonifera on total reactive oxygen species (ROS) generation Protective effect of marine algae phlorotannins against AAPH-induced oxidative stress in zebrafish embryo Dieckol isolated from brown seaweed Ecklonia cava attenuates type II diabetes in db/db mouse model Protective effect of dieckol isolated from Ecklonia cava against ethanol caused damage in vitro and in zebrafish model Phlorotannin-rich Ecklonia cava reduces the production of betaamyloid by modulating alpha-and gamma-secretase expression and activity Dieckol, a component of Ecklonia cava, suppresses the production of MDC/CCL22 via down-regulating STAT1 pathway in interferon-c stimulated HaCaT human keratinocytes Acetylcholinesterase inhibitory activity of phlorotannins isolated from the brown alga, Ecklonia maxima (Osbeck) Papenfuss Anti-HIV-1 activity of phlorotannin derivative 8,4 000 -dieckol from Korean brown alga Ecklonia cava Phlorotannins suppress adipogenesis in pre-adipocytes while enhancing osteoblastogenesis in pre-osteoblasts Role of ERK/MAPK signaling pathway in antiinflammatory effects of Ecklonia cava in activated human mast cell line-1 cells Enzyme-treated Ecklonia cava extract inhibits adipogenesis through the downregulation of C/EBPa in 3T3-L1 adipocytes Hepatoprotective constituents of the edible brown alga Ecklonia stolonifera on tacrine-induced cytotoxicity in HepG2 cells Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and anti-inflammatory properties keywords: activity; algae; anti; brown; cancer; cava; cells; dieckol; ecklonia; ecklonia cava; effects; et al; expression; extract; glucose; human; inhibited; inhibitory; marine; mice; oxidative; pff; phlorotannins; potential; production; protein; ros cache: cord-291559-h6czy5bh.txt plain text: cord-291559-h6czy5bh.txt item: #70 of 112 id: cord-292286-ygomb3oi author: Zakaryan, Hovakim title: Flavonoids: promising natural compounds against viral infections date: 2017-05-25 words: 6103 flesch: 31 summary: Apigenin inhibits enterovirus 71 replication through suppressing viral IRES activity and modulating cellular JNK pathway Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro Phenolic acids act as signaling molecules in plant-microbe symbioses Identification and evaluation of antihepatitis C virus phytochemicals from Eclipta alba Computational docking study of p7 Ion channel from HCV genotype 3 and genotype 4 and its interaction with natural compounds A flavonoid, luteolin, cripples HIV-1 by abrogation of tat function The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer Evaluation of the antiviral activity of kaempferol and its glycosides against human cytomegalovirus Metabolomics view on gut microbiome modulation by polyphenol-rich foods Baicalin, a metabolite of baicalein with antiviral activity against dengue virus Combined effects of flavonoids and acyclovir against herpesviruses in cell cultures Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyland sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions Anti-chikungunya activity ofl uteolin and apigenin rich fraction from Cynodon dactylon Neuroprotective effects of chrysin: from chemistry to medicine Differential inhibition of HIV-reverse transcriptase and various DNA and RNA polymerases by somecatechin derivatives Differential inhibitory effects of some catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and cellular deoxyribonucleic and ribonucleic acid polymerases Inhibition of the infectivity of influenza virus by tea polyphenols Antiviral activity of baicalin against influenza virus H1N1-pdm09 is due to modulation of NS1-mediated cellular innate immune responses Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial silico study on anti-Chikungunya virus activity of hesperetin Anti-Sindbis activity of flavanones hesperetin and naringenin Anti-HIV-1 activity of flavonoid myricetin on HIV-1 infection in a dual-chamber in vitro model Plant derived compounds having activity against P388 and L1210 leukemia cells Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays Genistein inhibits the replication of avian leucosis virus subgroup J in DF-1 cells Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice Drugs of natural origin Genistein as antiviral drug against HIV ion channel Absorption and metabolism of polyphenols in the gut and impact on health Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirus Comparison of the antiviral activity of flavonoids Antiviral activity of flavonoids against murine norovirus and feline calicivirus Computational approach towards exploring potential anti-Chikungunya activity of selectedflavonoids The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin Interestingly, naringin, the glycoside form of naringenin did not have anti-Sindbis virus activity, indicating that the rutinose moiety of this flavanone blocks its antiviral effect. keywords: activity; anti; cells; compounds; effect; egcg; flavonoids; infection; influenza; inhibition; inhibits; kaempferol; quercetin; replication; studies; tea; virus cache: cord-292286-ygomb3oi.txt plain text: cord-292286-ygomb3oi.txt item: #71 of 112 id: cord-293867-c4wnr5xe author: Gürsoy, Elif title: Design and synthesis of novel Imidazo[2,1-b]thiazole derivatives as potent antiviral and antimycobacterial agents date: 2019-12-06 words: 3030 flesch: 49 summary: The broad antiviral evaluation demonstrated that compound 5d was quite effective against Feline coronavirus in CRFK cells (Table 2) , with an antiviral EC 50 value of 4.8 µg/mL and a superior selectivity index (ratio of cytotoxic to antiviral concentration) higher than 20. The antiviral activity and cytotoxicity of the compounds against Feline corona and Feline herpes viruses were investigated in CRFK cell cultures and in comparison with HHA, UDA and Ganciclovir references, compound 5d was found as highly effective. keywords: activity; antiviral; compounds; derivatives; spirothiazolidinone cache: cord-293867-c4wnr5xe.txt plain text: cord-293867-c4wnr5xe.txt item: #72 of 112 id: cord-293974-jcpkla55 author: Simões, Marta Filipa title: Mycogenic Metal Nanoparticles for the Treatment of Mycobacterioses date: 2020-09-02 words: 6798 flesch: 29 summary: Bactericidal effect of silver nanoparticles against Mycobacterium tuberculosis Preparation and biological evaluation of ethionamide-mesoporous silicon nanoparticles against Mycobacterium tuberculosis Lipophilic pyrazinoic acid amide and ester prodrugs: Stability, activation and activity against Mycobacterium tuberculosis Anti-bacterial activity of inorganic nanomaterials and their antimicrobial peptide conjugates against resistant and non-resistant pathogens Antimicrobial peptides in innate immunity against mycobacteria Exploiting chitosan and gold nanoparticles for antimycobacterial activity of in silico identified antimicrobial motif of human neutrophil peptide-1 Antimicrobial host defence peptides: Functions and clinical potential Screening of filamentous fungi for antimicrobial silver nanoparticles synthesis Metal-based nanoparticles as antimicrobial agents: An overview Antimicrobial silver in medicinal and consumer applications: A patent review of the past decade Fungi-assisted silver nanoparticle synthesis and their applications Biogenic metal nanoparticles: A new approach to detect life on Mars? Calmette-Guérin An investigation on the antibacterial, cytotoxic, and antibiofilm efficacy of starch-stabilized silver nanoparticles Ipomea carnea-based silver nanoparticle synthesis for antibacterial activity against selected human pathogens A rapid screening assay for identifying mycobacteria targeted nanoparticle antibiotics Antibacterial and hemolytic activity of green silver nanoparticles from Catharanthus roseus Green synthesis of silver nanoparticles and their activity against Mycobacterium tuberculosis Nanosilver biosynthesis by Moringa oleifera and Allium cepa and antimycobacterial study Modulation of human macrophage responses to Mycobacterium tuberculosis by silver nanoparticles of different size and surface modification Anti-tubercular activity of silver nanoparticle synthesized from the fruits of Coriandrum sativum Linn Plumbago auriculata leaf extract-mediated AgNPs and its activities as antioxidant, anti-TB and dye degrading agents Biogenic silver nanoparticles as potential agent against Mycobacterium tuberculosis Phytofabrication of fluorescent silver nanoparticles from Leucaena leucocephala L. leaves and their biological activities Efficiency of biosynthesized silver and zinc nanoparticles against multi-drug resistant pathogens Nanomedicines towards targeting intracellular Mtb for the treatment of tuberculosis Synthesis of silver nanoparticles mediated by fungi: keywords: activity; agnps; drug; fungal; fungi; mnps; mtb; mycobacterium; mycogenic; nanoparticles; silver; species; synthesis; tuberculosis cache: cord-293974-jcpkla55.txt plain text: cord-293974-jcpkla55.txt item: #73 of 112 id: cord-294897-29diwyoe author: Pina-Pérez, M. C. title: Antimicrobial potential of macro and microalgae against pathogenic and spoilage microorganisms in food date: 2017-11-15 words: 9246 flesch: 28 summary: Several products, such as pasta, bread, and snacks, are being developed with the incorporation of algae extracts in their formulation, and expectations about this practice are promising for the food industry. The antimicrobial potential of algae extracts is dependent on the capability of the solvent to extract certain bioactive compounds, and also dependent on the sensitiveness of bacteria or fungi to these selective extracted compounds (Al-Saif et al., 2014; Cakmak et al., 2014) . keywords: activity; algae; antibacterial; antimicrobial; aureus; compounds; et al; extraction; extracts; food; inhibition; marine; microalgae; potential; products; seaweed; spp; zone cache: cord-294897-29diwyoe.txt plain text: cord-294897-29diwyoe.txt item: #74 of 112 id: cord-295335-oa4twg2z author: Pastorino, Giulia title: Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review date: 2018-08-17 words: 8276 flesch: 26 summary: Antidepressive activity G. glabra aqueous extract 75-300 mg/kg The use of G. glabra extract as antiulcerative is widely known. keywords: 18β; acid; activity; antioxidant; apoptosis; cells; compounds; effects; et al; extract; g. glabra; glabra; glabridin; glycyrrhetinic; glycyrrhiza glabra; glycyrrhizin; inhibition; licochalcone; licorice; liquorice; mice; root; treatment cache: cord-295335-oa4twg2z.txt plain text: cord-295335-oa4twg2z.txt item: #75 of 112 id: cord-295543-nj4a640t author: Castañeda-Babarro, Arkaitz title: Physical Activity Change during COVID-19 Confinement date: 2020-09-21 words: 3602 flesch: 46 summary: In the subgroup analysis, the most active subjects showed the highest decrease in vigorous activity time (30.5%, p < 0.001) The most active subjects showed the highest decrease in vigorous activity time and this may be explained by two main reasons: the forced sudden inaccessibility to community resources (e.g., sports facilities, urban trails, parks, green spaces, etc.) and the lack of time to react during the first weeks of confinement to gather fitness resources, in order to continue engaging in regular activities at home. keywords: activities; activity; confinement; min; population; time cache: cord-295543-nj4a640t.txt plain text: cord-295543-nj4a640t.txt item: #76 of 112 id: cord-296769-xnjmk4pm author: Valentová, Kateřina title: Cytoprotective Activity of Natural and Synthetic Antioxidants date: 2020-08-06 words: 1157 flesch: 17 summary: Antioxidant activities of pure stereomers A and B of silybin and 2,3-dehydrosilybin, their racemic mixtures, pure silychristin A, and its derivatives (anhydrosilychristin, isosilychristin, and 2,3-dehydrosilychristin A) were investigated by using ORAC and CAA assays. key: cord-296769-xnjmk4pm authors: Valentová, Kateřina title: Cytoprotective Activity of Natural and Synthetic Antioxidants date: 2020-08-06 journal: Antioxidants (Basel) DOI: 10.3390/antiox9080713 sha: doc_id: 296769 cord_uid: xnjmk4pm Numerous chronic diseases including cancer, cardiovascular, chronic respiratory or neurodegenerative diseases, diabetes mellitus, retinal damage, and others are associated with oxidative stress keywords: activity; antioxidant; effects; oxidative; stress cache: cord-296769-xnjmk4pm.txt plain text: cord-296769-xnjmk4pm.txt item: #77 of 112 id: cord-299007-5m6lk409 author: Paterson, R. Russell M. title: Cordyceps – A traditional Chinese medicine and another fungal therapeutic biofactory? date: 2008-05-31 words: 19555 flesch: 36 summary: The effects of aqueous extracts of some crude drugs in shortterm screening test Militarinone A, a neurotrophic pyridone alkaloid from Paecilomyces militaris (+)-N-Deoxymilitarinone A, a neuritogenic pyridone alkaloid from the insect pathogenic fungus Paecilomyces farinosus Down-regulation of apoptotic and inflammatory genes by Cordyceps sinensis extract in rat kidney following ischemia/reperfusion Treatment of hyperlipidemia with cultivated Cordyceps -a double-blind, randomized placebo control trial Trade of Cordyceps sinensis from high altitudes of the Indian Himalaya: conservation and biotechnological priorities Effect of Cordyceps militaris on the damage of rats induced by n-hexane Profiles of nucleosides and nitrogen bases in Chinese medicinal fungus Cordyceps sinensis and related species Pharmacological activities of Paecilomyces japonica, a new type Cordyceps sp Anti-tumour and immuno-stimulating activities of the fruiting bodies of Paecilomyces japonica, a new type of Cordyceps spp Antioxidant and immunostimulating activities of the fruiting bodies of Paecilomyces japonica, a new type of Cordyceps sp Pharmacological basis of 'Yin-nourishing' and 'Yang-invigorating' actions of Cordyceps, a Chinese tonifying herb Chemotaxonomy of Pochonia and other conidial fungi with Verticillium like anamorphs Clinical study on application of bailing capsule after renal transplantation Cordyceps sinensis and cultured mycelia Phylogenetic classification of Cordyceps and the clavicipitaceous fungi Effects of Cordyceps sinensis, rhubarb and serum renotropin on tubular epithelial cell growth DMSO modifies structural and functional properties of RPMI-8402 cells by promoting programmed cell death Rapid and specific detection of hydroxyl radical using an ultraweak chemiluminescence analyzer and a low-level chemiluminescence emitter: application to hydroxyl radicalscavenging ability of aqueous extracts of food constituents Free radical scavenging and apoptotic effects of Cordyceps sinensis fractionated by supercritical carbon dioxide Effects of a watersoluble extract of Cordyceps sinensis on steroidogenesis and capsular morphology of lipid droplets in cultured rat adrenocortical cells Pharmacological functions of Chinese medicinal fungus Cordyceps sinensis and related species An experimental study on anti-aging action of Cordyceps extract Entomogenous fungi that produce 2,6-pyridine dicarboxylic acid (dipicolinic acid) Immunomodulatory functions of extracts from the Chinese medicinal fungus Cordyceps cicadae Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris Lead poisoning caused by contaminated Cordyceps, a Chinese herbal medicine: two case reports Structural analysis of a neutral (1 ? 3),(1 ? Carbohydr Macrophage biospecific extraction and high performance liquid chromatography for hypothesis of immunological active components in Cordyceps sinensis Simultaneous determination of free ergosterol and ergosteryl esters in Cordyceps sinensis by HPLC Anti-diabetic effects of CCCA, CMESS, and Cordycepin from Cordyceps militaris and the immune responses in streptozotocin-induced diabetic mice Prosecutable function of Cordyceps sinensis extracts for hepatic mitochondrial oxidative injuries in diabetic mice Induction of HL-60 apoptosis by ethyl acetate extract of Cordyceps sinensis fungal mycelium Activation of murine peritoneal macrophages by natural Cordyceps sinensis and its cultured mycelia Lewis lung cancer of mice treated with Cordyceps sinensis and its artificial cultured mycelia Effects of the exopolysaccharide fraction (EPSF) from a cultivated Cordyceps sinensis on immunocytes of H22 tumor bearing mice Immunomodulatory and antitumour effects of an exopolysaccharide fraction from cultivated Cordyceps sinensis (Chinese caterpillar fungus) on tumourbearing mice Dynamical influence of Cordyceps sinensis on the activity of hepatic insulinase of experimental liver cirrhosis Influence of Cordyceps sinensis on pancreatic islet beta cells in rats with experimental liver fibrogenesis Epicoccins A-D, pipolythiodioxopiperazines from a Cordyceps-colonizing isolate of Epicoccum nigrum Clinical and experimental studies on elimination of oxygen free radical of jinshuibao capsule in treating senile deficiency syndrome and its deoxyribonucleic acid damage repairing effects Cordyceps sinensis -I as an immunosuppressant in heterotopic heart allograft model in rats CordyMax Cs-4 improves glucose metabolism and increases insulin sensitivity in normal rats Inhibitory effect of Cordyceps sinensis and Cordyceps militaris on human glomerular mesangial cell proliferation induced by native LDL Investigation on distribution and habitat of Blaps rynchopetera fairmaire (Coleoptera: Tenebrionidae) in Yunnan Cordyceps sinensis in protection of the kidney from cyclosporine keywords: activities; activity; anti; apoptosis; authors; bodies; body; cells; compounds; cordyceps; cordyceps sinensis; cultured; effects; et al; extracts; fungal; fungi; fungus; growth; human; insect; medicine; mice; militaris; mycelia; polysaccharide; production; proliferation; rats; sinensis; species; treatment; tumour cache: cord-299007-5m6lk409.txt plain text: cord-299007-5m6lk409.txt item: #78 of 112 id: cord-300522-okbupw61 author: Sansone, Clementina title: Marine Algal Antioxidants as Potential Vectors for Controlling Viral Diseases date: 2020-05-07 words: 4779 flesch: 24 summary: Antiviral activity of sulfated polysaccharides carrageenan from some marine seaweeds In vitro inhibition of human papillomavirus following use of a carrageenan-containing vaginal gel Iota-carrageenan is a potent inhibitor of influenza A virus infection Antiviral Activity of a Carrageenan from Gigartina skottsbergii against Intraperitoneal Murine Herpes simplex Virus Infection Iota-Carrageenan is a potent inhibitor of rhinovirus infection Preparation and potential in vivo anti-influenza virus activity of low molecular-weight κ-carrageenans and their derivatives Galactans: An Overview of their Most Important Sourcing and Applications as Natural Polysaccharides Antiviral Potential of Algae Polysaccharides Isolated from Marine Sources: A Review Marine compounds and their antiviral activities Antiviral activities of sulfated polysaccharides isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales) Thus, thousands of compounds from various marine organisms such as algae, bacteria, fungi, marine invertebrates or sponges have been screened and 21 of them have demonstrated antiviral activities [17] . keywords: activities; activity; algae; antioxidant; antiviral; cell; compounds; human; infection; marine; polysaccharides; stress; virus cache: cord-300522-okbupw61.txt plain text: cord-300522-okbupw61.txt item: #79 of 112 id: cord-300872-blycbi4u author: Saadeh, Haythem A. title: Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines date: 2020-09-21 words: 16497 flesch: 40 summary: In this context, Hu and coworkers prepared new derivatives of the known potent antibacterial agent 2,6-difluoro-3-hydroxybenzamide (DFMBA) In this context, Hu and coworkers prepared new derivatives of the known potent antibacterial agent 2,6-difluoro-3-hydroxybenzamide (DFMBA) keywords: activities; activity; cancer; cell; compounds; derivatives; drug; group; hydroxyquinoline; inhibition; presence; reaction; results; scheme; standard; synthesis; target; values cache: cord-300872-blycbi4u.txt plain text: cord-300872-blycbi4u.txt item: #80 of 112 id: cord-303468-95btvr1v author: Verran, Joanna title: Biofilm Control Strategies: Engaging with the Public date: 2020-07-30 words: 3149 flesch: 40 summary: Yet, in a review of public engagement activity around AMR, a rich bedrock of activity was found only through personal contacts and communication rather than through a literature search [4] . Public engagement activities can be designed with clear aims that enable effective evaluation using both quantitative and qualitative methods. keywords: activities; activity; biofilm; engagement; panels; participants; plaque; public cache: cord-303468-95btvr1v.txt plain text: cord-303468-95btvr1v.txt item: #81 of 112 id: cord-303646-uxewsyli author: Janas, Roman M. title: Further Studies on Aminopeptidase-M in Blood in Children with Cholestatic Liver Diseases and Viral Hepatitis date: 1999 words: 4619 flesch: 56 summary: An increase of e nzyme activity as a result of dilution sugge sts that a large portion of the enzyme molecule s is not hydrolytically active and is prese nt in the se rum as a cryptic fraction. We atte mpte d to de te rmine and characte rize the e xpre ssion and prope rtie s of se rum aminope ptidase -M activity in childre n with live r diseases and in he althy childre n. keywords: acid; activity; aminope; childre; chole; dilution; nzyme; patitis; ptidase; serum cache: cord-303646-uxewsyli.txt plain text: cord-303646-uxewsyli.txt item: #82 of 112 id: cord-303879-3hug5hj3 author: Cushnie, T.P. Tim title: Antimicrobial activity of flavonoids date: 2005-10-19 words: 8016 flesch: 35 summary: and Pseudomonas aeruginosa Two antimicrobial flavanones from the leaves of Glycyrrhiza glabra Antimicrobial activities of constituents of Uvaria chamae In vitro anti-Helicobacter pylori activity of some flavonoids and their metabolites Anti-Helicobacter pylori activity of the metabolites of poncirin from Poncirus trifoliata by human intestinal bacteria Antimicrobial evaluation of coumarins and flavonoids from the stems of Daphne gnidium L Anti-MRSA activity of sophoraflavanone G and synergism with other antibacterial agents Antibacterial activity of flavanone isolated from Sophora exigua against methicillin-resistant Staphylococcus aureus and its combination with antibiotics Inhibition of the growth of cariogenic bacteria in vitro by plant flavanones Examination of coumarins, flavonoids and polysaccharopeptide for antibacterial activity Antibacterial action of some naturally occurring citrus bioflavonoids Bactericidal catechins damage the lipid bilayer Antibacterial activity of epigallocatechin gallate against methicillin-resistant Staphylococcus aureus Antibacterial substances in Japanese green tea extract against Streptococcus mutans, a cariogenic bacterium Microbiological activity of whole and fractionated crude extracts of tea (Camellia sinensis), and of tea components Anti-Helicobacter pylori activity of Chinese tea: in vitro study Mechanism of synergy between epigallocatechin gallate and beta-lactams against methicillin-resistant Staphylococcus aureus Anti-Staphylococcus aureus activity and oxacillin resistance modulating capacity of 3-O-acyl-catechins Antimicrobial activity of 10 different plant polyphenols against bacteria causing food-borne disease Antibacterial activity studies of flavonoids from Salvia palaestina Isolation of antimicrobial compounds from guava (Psidium guajava L.) and their structural elucidation Antimicrobial activities of some flavonoid compounds Antibacterial activity of Achyrocline flaccida Antimicrobial principles from in vitro tissue culture of Tribulus alatus Isolation of flavonoids and a chalcone from Helichrysum odoratissimum and synthesis of helichrysetin Quercetin 3-O-galactosyl-(1-6)-glucoside, a compound from narrowleaf vetch with antibacterial activity Isolation and antimicrobial activity of flavonoids from Prunus spinosa L. flowers Antibacterial activity of flavonoids against methicillin-resistant Staphylococcus aureus strains Two new flavones from Calliandra californica Antibacterial flavonoids from Helichrysum picardii and H. italicum Flavones with antibacterial activity against cariogenic bacteria A new flavone glycoside with antimicrobial activity from Carduus pycnocephalus L A rare antibacterial flavone glucoside from Lantana camara Studies on the antibacterial potentiality of isoflavones Antimicrobial and radical scavenging flavonoids from the stem wood of Erythrina latissima Antimicrobial activity of two flavanones isolated from the Cameroonian plant Erythrina sigmoidea New antimicrobial flavanones from Physena madagascariensis Antibacterial and antiandrogen flavonoids from Sophora flavescens Isoflavanones from the heartwood of Swartzia polyphylla and their antibacterial activity against cariogenic bacteria Antimicrobial flavonoids from Glycyrrhiza glabra hairy root cultures Structure and biological activity of a new rotenoid from Pongamia pinnata Shamimin: a new flavonol C-glycoside from leaves of Bombax ceiba Acylated flavonol glycosides from leaves of Stenochlaena palustris However, several high-quality investigations have examined the relationship between flavonoid structure and antibacterial activity and these are in close agreement. keywords: action; activity; agents; antibacterial; aureus; colleagues; compounds; dna; flavones; flavonoids; groups; inhibition; membrane; plant; propolis; quercetin; research; staphylococcus cache: cord-303879-3hug5hj3.txt plain text: cord-303879-3hug5hj3.txt item: #83 of 112 id: cord-304375-l5gvpat3 author: Singh, Kamaljit title: 2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure–activity relationship and mode of action studies date: 2012-03-13 words: 6633 flesch: 45 summary: Evidently, the compounds have anti-plasmodial activity in the nM range and against the CQ R strain of P. falciparum, in some cases activity was found to be even superior to CQ. Replacing the C-4 phenyl group in 10c by a methyl group to create 10m resulted in nearly 5 times increase in anti-plasmodial activity (IC 50 42.1 nM) against the CQ S strain. keywords: 10c; 10r; activity; anti; binding; cell; compounds; dna; drug; heme; interaction; strain; table; virus cache: cord-304375-l5gvpat3.txt plain text: cord-304375-l5gvpat3.txt item: #84 of 112 id: cord-307983-gjdza9bh author: Hawdon, James title: Cybercrime in America amid COVID-19: the Initial Results from a Natural Experiment date: 2020-06-10 words: 6049 flesch: 38 summary: Fortune Crime rates plummet around the world as the coronavirus keeps people inside Phishing for suitable targets in the Netherlands: Routine activity theory and phishing victimization Applying routine activity theory to cybercrime: A theoretical and empirical analysis The accuracy of measurements with probability and nonprobability survey samples: Replication and extension Identifying potential factors of adolescent online victimization for high school seniors Adolescent online victimization: A test of routine activities theory Potential factors of online victimization of youth: With this modification in mind, online routine activities can increase the likelihood of victimization by bringing potential targets into virtual contact with offenders in environments lacking guardians (see Eck & Clarke, 2003; Reyns et al., 2011) . keywords: activities; covid-19; cybervictimization; increase; online; pandemic; post; routine; sample; target; victimization cache: cord-307983-gjdza9bh.txt plain text: cord-307983-gjdza9bh.txt item: #85 of 112 id: cord-309052-3h0g7s9v author: Alam, Fiaz title: Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: A review date: 2017-12-15 words: 9688 flesch: 36 summary: Missouri Botanical Garden and University of Inhibition behavior of fructus psoraleae's ingredients towards human carboxylesterase 1 (hCES1) DNA polymerase and topoisomerase II inhibitors from Psoralea c orylifolia Gonadal toxicity of an ethanol extract of Psoralea corylifolia in a rat 90-day repeated dose study Psoralen stimulates osteoblast differentiation through activation of BMP signaling Review article: Herbal hepatotoxicity-an update on traditional Chinese medicine preparations New constituents from Psoralea corylifolia Histone deacetylase inhibitor sodium butyrate enhances the cell killing effect of psoralen plus UVA by attenuating nucleotide excision repair Psoralea corylifolia extract ameliorates experimental osteoporosis in ovariectomized rats Screening south Indian medicinal plants for antifungal activity against cutaneous pathogens Osteoblastic proliferation stimulating activity of Psoralea corylifolia extracts and two of its flavonoids Chemical constituents from Psoralea corylifolia and their antioxidant alphaglucosidase inhibitory and antimicrobial activities. The low polarity ether extract of P. corylifolia seeds was investigated, and it revealed the presence of various ketones and aldehydes containing compounds such as Corylinal, C-formylated chalcone, and Isoneobayachalcone. keywords: activity; anti; antibacterial; anticancer; antioxidant; bakuchiol; cells; compounds; corylifolia; dose; effects; et al; extract; flavonoid; fruit; human; inhibition; medicinal; plant; psoralea corylifolia; psoralen; psoralidin; seeds; study; vitro cache: cord-309052-3h0g7s9v.txt plain text: cord-309052-3h0g7s9v.txt item: #86 of 112 id: cord-315918-12rbbe8c author: Mukherjee, Pulok K. title: Antiviral Evaluation of Herbal Drugs date: 2019-06-21 words: 12824 flesch: 39 summary: Many combinations of test viruses are possible, but a battery of six viruses seems to be quite acceptable. This assay is applicable for HIV-1, simian immunodeficiency virus (SIV), and simian-HIV and is carried out in TZM-bl cells as it reveal the reduction in Tat-induced luciferase (Luc) reporter gene expression after a single round of virus infection. keywords: acid; activities; activity; antiviral; assay; cells; compounds; control; culture; drug; et al; extracts; herpes; hiv; incubate; infection; medicinal; medium; plant; replication; screening; test; virus; viruses cache: cord-315918-12rbbe8c.txt plain text: cord-315918-12rbbe8c.txt item: #87 of 112 id: cord-318528-yc0jw3s1 author: Romero-Blanco, Cristina title: Physical Activity and Sedentary Lifestyle in University Students: Changes during Confinement Due to the COVID-19 Pandemic date: 2020-09-09 words: 4389 flesch: 48 summary: We do not know the exact reasons why physical activity increased, and we do not know if the effects on physical activity habits would have been maintained if the lockdown had gone on for longer. We expected to find an increase in sitting time due to the restrictions on movement; however, we also thought that the increase in screen time would reduce physical activity time, since in previous studies conducted in the Spanish university population, more screen time was associated with higher inactivity levels [31] . keywords: activity; behaviour; health; lockdown; students; study; time; university cache: cord-318528-yc0jw3s1.txt plain text: cord-318528-yc0jw3s1.txt item: #88 of 112 id: cord-318854-xaus3bma author: Sun, Yi title: Chapter 4 Bioactivity and Synthesis of Diarylheptanoids From Alpinia officinarum date: 2016-12-31 words: 5371 flesch: 48 summary: [61, 62] examined the antiinfluenza virus activity and cytotoxicity of 10 diarylheptanoids (2, 4, 6, 21, 24, 30, 32, 35, 36, and 49) isolated from A. officinarum by plaque reduction assay and MTT assay, respectively, using Madin-Darby canine kidney (MDCK) cells (Table 4 .4). Thus, hydroxylation at the C-4 position of the phenyl moiety may be important for antiinfluenza virus activity in vitro. keywords: activities; activity; cells; compounds; diarylheptanoids; fig; group; officinarum; virus cache: cord-318854-xaus3bma.txt plain text: cord-318854-xaus3bma.txt item: #89 of 112 id: cord-320693-de1lmzl1 author: Hu, Han title: Antiviral activity of Piscidin 1 against pseudorabies virus both in vitro and in vivo date: 2019-07-31 words: 5060 flesch: 48 summary: Residual virus was calculated according to the following formula, residual infectivity = b/a × 100% (a represent TCID50 of residual virus non-treated by the AMPs (control), b represent TCID50 of residual virus after treated by AMPs). Although vaccination can suppress development of the disease, vaccines cannot eliminate virus infection. keywords: activity; caerin; infection; mice; peptides; piscidin; prv; virus; viruses cache: cord-320693-de1lmzl1.txt plain text: cord-320693-de1lmzl1.txt item: #90 of 112 id: cord-321985-w84wwkgi author: Xing, Shihua title: Simulated gastrointestinal tract metabolism and pharmacological activities of water extract of Scutellaria baicalensis roots date: 2014-02-27 words: 4494 flesch: 37 summary: In our studies, baicalin, baicalein, oroxylin A and norwogonin, four typical flavones possessed different degree of antimicrobial activities. Intestinal bacterial hydrolysis is indispensable to absorption of 18 beta-glycyrrhetic acid after oral administration of glycyrrhizin in rats Baicalin, the predominant flavone glucuronide of Scutellariae Radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form Antimicrobial and antioxidant activities of methanol extracts of Evax pygmaea (Asteraceae) growing wild in Tunisia Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cells Antimicrobial activity of flavonoids Bactericidal catechins damage the lipid bilayer Anticomplement activity of tiliroside from the flower buds of Magnolia fargesi Microassay for colorimetric estimation of complement activity in guinea pig, human and mouse serum Contents of major bioactive flavones in proprietary traditional Chinese medicine products and reference herb of Radix scutellariae The antioxidative effect of icariin in human erythrocytes against free-radicalinduced haemolysis Fecal metabolic activities of herbal components to bioactive compounds Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats Flavone mutagenicity in Salmonella typhimurium: dependence on the pKM101 plasmid and excision-repair deficiency Complement and complement fixation Rapid characterization of chemical constituents and rats metabolites of the traditional Chinese patent medicine Gegen-Qinlian-Wan by UHPLC/DAD/qTOF-MS Extracts of Scutellaria for the Treatment of SARS. keywords: activity; bacteria; baicalin; huangqin; human; norwogonin; wesb cache: cord-321985-w84wwkgi.txt plain text: cord-321985-w84wwkgi.txt item: #91 of 112 id: cord-324217-secnz2ta author: Pasdaran, A. title: Volatile oils: Potential agents for the treatment of respiratory infections date: 2016-08-05 words: 7717 flesch: 28 summary: The estimation of essential oil activity both in agar and liquid broth would be simplified through counting the tested microorganisms that can remain in the membrane. Essential oil is one of the most important and wide spread secondary metabolite in plants and this class of phytochemical compounds and their activities needs attention. keywords: activity; antiviral; bacteria; cell; chemical; compounds; effects; gram; infections; inflammation; membrane; microorganisms; oils; plants; potential; tract; treatment cache: cord-324217-secnz2ta.txt plain text: cord-324217-secnz2ta.txt item: #92 of 112 id: cord-324335-eoabmyg7 author: Nicoletti, Marcello title: New solutions using natural products date: 2020-08-21 words: 31242 flesch: 42 summary: Other studies on resistance mechanisms of Plasmodium are enabling new possible methods of control always based on natural products activity. and biotic targets, which are important to the individual homeostasis and survival. key: cord-324335-eoabmyg7 authors: Nicoletti, Marcello title: New solutions using natural products date: 2020-08-21 journal: Insect-Borne Diseases in the 21st Century DOI: 10.1016/b978-0-12-818706-7.00007-3 sha: doc_id: 324335 cord_uid: eoabmyg7 Most antibiotics are derived from natural products, like penicillin, as well as recent insecticides, like pyrethroids. keywords: action; activity; azadirachta; cake; case; cell; chemical; chloroquine; composition; compounds; constituents; control; drugs; effects; environmental; et al; extract; food; indica; information; insect; insecticide; larvae; leaves; life; madagascar; malaria; mosquito; neem; new; nso; oil; oils; packaging; plant; plasmodium; production; products; properties; research; resistance; role; species; study; treatment; tree; use; utilization; years cache: cord-324335-eoabmyg7.txt plain text: cord-324335-eoabmyg7.txt item: #93 of 112 id: cord-327521-g5vefajw author: Spisni, Enzo title: Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Essential Oils: Implications in Colonic Pathophysiology date: 2020-06-10 words: 9207 flesch: 30 summary: Anti-Cancer Drugs Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo-205 cells by inducing apoptosis, DNA damage and cell cycle arrest Geraniol, a component of plant essential oils, inhibits growth and polyamine biosynthesis in human colon cancer cells Polyamine metabolism and gene methylation in conjunction with one-carbon metabolism Thymol elicits HCT-116 colorectal carcinoma cell death through induction of oxidative stress Cinnamaldehyde affects the biological behaviour of human colorectal cancer cells and induces apoptosis via inhibition of the PI3K/Akt signalling pathway Novel cinnamaldehyde-based aspirin derivatives for the treatment of colorectal cancer Dual acid-responsive micelle-forming anticancer polymers as new anticancer therapeutics Perturbation by geraniol of cell membrane permeability and signal transduction pathways in human colon cancer cells Geraniol, a component of plant essential oils, sensitizes human colonic cancer cells to 5-fluorouracil treatment Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts Identification of genetic susceptibility loci for colorectal tumors in a genome-wide meta-analysis Red meat and colon cancer: A review of mechanistic evidence for heme in the context of risk assessment methodology Alcohol, smoking and the risk of premalignant and malignant colorectal neoplasms The gut microbiota, bacterial metabolites and colorectal cancer Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis Molecular genetics of colorectal cancer Clinical management of hereditary colorectal cancer syndromes Balancing the efficacy and toxicity of chemotherapy in colorectal cancer Pharmacologic resistance in colorectal cancer: A review Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells. keywords: activities; activity; antioxidant; bacteria; cancer; carvacrol; cell; cinnamaldehyde; colitis; colon; effects; eos; geraniol; human; microbiota; molecules; oils; studies; thymol; vitro cache: cord-327521-g5vefajw.txt plain text: cord-327521-g5vefajw.txt item: #94 of 112 id: cord-328176-fck2ktxi author: Mahapatra, Manojkumar title: Methyl-2-arylidene hydrazinecarbodithioates: synthesis and biological activity date: 2013-02-19 words: 2429 flesch: 36 summary: Compound IIc and IIl show antiviral activity against wild-type herpes simplex virus (HSV), varicella zoster virus (VZV), and acyclovirresistant HSV; however, these activities were observed at concentrations at which the compounds also markedly inhibit HL60 and HEL cell proliferation. With this background, twelve MAHCD derivatives were synthesised and evaluated for anticancer activity against HL60 human promyelocytic leukemia cells and antiviral activity against a panel of viral cell lines. keywords: activity; cells; compounds; iil; virus cache: cord-328176-fck2ktxi.txt plain text: cord-328176-fck2ktxi.txt item: #95 of 112 id: cord-328834-yetnlb2j author: Mohsin, Noor ul Amin title: Current Strategies in Development of New Chromone Derivatives with Diversified Pharmacological Activities: A Review date: 2020-06-15 words: 5738 flesch: 52 summary: Later on, Ceylan-unlusoy, et al. synthesized chromone derivatives having imidazolidindione, 2,4-thiazolidindione and 2-thioxoimidazolidine-4-one heterocyclic cores. Ali, et al. synthesized chromone annulated phosphorous heterocycles as anticancer agents. keywords: activity; chromone; compound; derivatives; group cache: cord-328834-yetnlb2j.txt plain text: cord-328834-yetnlb2j.txt item: #96 of 112 id: cord-330660-tx20im6w author: Mahmoud, Huda K. title: Nano-sized Formazan analogues: Synthesis, structure elucidation, antimicrobial activity and Docking study for COVID-19 date: 2020-10-07 words: 2551 flesch: 38 summary: The results showed mild to moderate antibacterial activities and moderate to potent antifungal activities. Target compounds 3a-e, 5a-h, 7b were evaluated for their in vitro antibacterial, and antifungal activities, by inhibition zone method against two gram-positive bacteria: Staphylococcus aureus (RCMB 010010) and Bacillus subtilis (RCMB 015), two gram-negative bacteria: Escherichia coli (RCMB 010052) and Proteus vulgaris (RCMB 004) and two fungi: keywords: activities; activity; analogues; compounds; docking; formazans; synthesis; trna cache: cord-330660-tx20im6w.txt plain text: cord-330660-tx20im6w.txt item: #97 of 112 id: cord-336165-if8uxqha author: Remoaldo, Paula title: Profiling the participants in creative tourism activities: Case studies from small and medium sized cities and rural areas from Continental Portugal date: 2020-09-12 words: 8800 flesch: 33 summary: Paper presented at the Cultural Tourism Conference, Bonavista Institute for Cultural Tourism Marketing 3.0: Produits, clients, facteurshumains Creative tourism: A global conversation Market segmentation Activities-based segmentation of the cultural tourism market Creative tourism experiences in Guimarães: A twofold analysis of visitors' and suppliers' perspectives Changes in consumer behaviour -the challenges for providers of tourist services in the destination Mindful visitors: Heritage and tourism Criatividade: a construção de novos cenários para o turismo em Ponte de Lima Defining cultural tourism. According to Richards (2011) , creativity can be used to implement creative tourism as a tourist activity, which involves the active involvement of tourists in the creative activities of the places they visit, or as a backdrop for tourism, in which tourists place themselves in a chosen creative environment. keywords: activities; cluster; community; cultural; experiences; motivations; participants; profile; research; richards; study; tourism; tourists; travel cache: cord-336165-if8uxqha.txt plain text: cord-336165-if8uxqha.txt item: #98 of 112 id: cord-336578-5qzpd890 author: Sethiya, Jigar P. title: MmpL3 Inhibition: A New Approach to Treat Nontuberculous Mycobacterial Infections date: 2020-08-27 words: 13745 flesch: 46 summary: Additionally, the azaspiroketal derivatives were found to be more potent than 5 against M. tb and directly bind MmpL3, as supported by cross-resistance with other MmpL3 inhibitors. The scaffold varies from other MmpL3 inhibitors and 20. keywords: abscessus; activity; cell; compound; drug; group; m. tb; mic; mmpl3; ntm; resistance; ring; species; treatment cache: cord-336578-5qzpd890.txt plain text: cord-336578-5qzpd890.txt item: #99 of 112 id: cord-338727-1kodz527 author: Ilinskaya, O. N. title: Ribonucleases as antiviral agents date: 2014-10-11 words: 4605 flesch: 37 summary: Furthermore, it has been found that siRNAs specific to a conserved region of influenza virus RNA introduced into a cell decreased the titer of the virus The study of the molecular mechanism of the action of antiviral RNases is undoubtedly an urgent task, the solution of which may promote the develop ment of novel antiviral preparations capable of pro tecting the organism independently of changes in the virus genome. keywords: activity; binase; cell; domain; effect; human; infection; influenza; protein; replication; ribonuclease; rnase; virus; viruses cache: cord-338727-1kodz527.txt plain text: cord-338727-1kodz527.txt item: #100 of 112 id: cord-339227-2i9q9c8u author: Djakpo, Odilon title: Rhus chinensis and Galla Chinensis – folklore to modern evidence: review date: 2010-11-22 words: 6271 flesch: 39 summary: (2006) found that Galla chinensis extract exhibited an anti-LT-induced diarrheal effect, with an IC 50 value of 4.7 ± 1.3 mg/mL. Competitive GM1-ELISA assay showed that Galla chinensis suppressed (IC 50 = 0.17 ± 0.02 mg/mL) LTinduced fl uid accumulation by blocking the binding of LTB to G M1 . Furthermore, Zou et al. (2008) , using the same protocol, demonstrated the potential of Galla chinensis extract to inhibit the demineralization of initial enamel carious lesions. keywords: acid; activity; antioxidant; cells; chinensis; chinese; compounds; effects; et al; extract; galla; galla chinensis; galloyl; glucose; human; pentagalloylglucose; rhus; vitro cache: cord-339227-2i9q9c8u.txt plain text: cord-339227-2i9q9c8u.txt item: #101 of 112 id: cord-339716-1khdh9nf author: Munasinghe, Sithum title: The Impact of Physical Distancing Policies During the COVID-19 Pandemic on Health and Well-Being Among Australian Adolescents date: 2020-10-21 words: 4649 flesch: 44 summary: After the implementation of physical distancing measures in NSW, there were significant decreases in physical activity (odds ratio [OR] = .53, 95% confidence interval There were significant decreases in physical activity in the period after the implementation of physical distancing measures in NSW. keywords: activity; distancing; food; health; participants; period; study; time cache: cord-339716-1khdh9nf.txt plain text: cord-339716-1khdh9nf.txt item: #102 of 112 id: cord-340879-gu91cact author: Li, Miao title: Isolation and Characterization of a Phaseolus vulgaris Trypsin Inhibitor with Antiproliferative Activity on Leukemia and Lymphoma Cells date: 2017-01-23 words: 4161 flesch: 46 summary: Gold bean trypsin inhibitor is dissimilar from broad bean trypsin inhibitor [9] in that the former lacks HIV-1 reverse transcriptase inhibitory activity. Gold bean trypsin inhibitor is dissimilar from broad bean trypsin inhibitor [9] in that the former lacks HIV-1 reverse transcriptase inhibitory activity. keywords: activity; antifungal; bean; cells; fraction; gel; gold; inhibitor; trypsin; trypsin inhibitor cache: cord-340879-gu91cact.txt plain text: cord-340879-gu91cact.txt item: #103 of 112 id: cord-342634-4ouhdjsr author: Semrad, Katharina title: Proteins with RNA Chaperone Activity: A World of Diverse Proteins with a Common Task—Impediment of RNA Misfolding date: 2010-12-26 words: 7147 flesch: 46 summary: RNA chaperones and the RNA folding problem A DEAD-Box protein functions as an ATP-dependent RNA chaperone in group I intron splicing Escherichia coli proteins, including ribosomal protein S12, facilitate in vitro splicing of phage T4 introns by acting as RNA chaperones Escherichia coli protein StpA stimulates self-splicing by promoting RNA assembly in vitro RNA chaperone activity and RNA-binding properties of the E. coli protein StpA Spectroscopic observation of RNA chaperone activities of Hfq in post-transcriptional regulation by a small non-coding RNA Hfq, a new chaperoning role: binding to messenger RNA determines access for small RNA regulator Geometric nomenclature and classification of RNA base pairs RNA tertiary interactions in the large ribosomal subunit: the A-minor motif Two interconvertible forms of tryptophanyl sRNA in E. coli Native and renatured transfer ribonucleic acid A ribosomal function is necessary for efficient splicing of the T4 phage thymidylate synthase intron in vivo Alternative secondary structures in the 5 exon affect both forward and reverse self-splicing of the Tetrahymena intervening sequence RNA A tyrosyl-tRNA synthetase recognizes a conserved tRNA-like structural motif in the group I intron catalytic core Domain structure and RNA annealing activity of the Escherichia coli regulatory protein StpA RNA annealing activities in HeLa nuclei HIV-1 nucleocapsid protein as a nucleic acid chaperone: spectroscopic study of its helix-destabilizing properties, structural binding specificity, and annealing activity Coupling RNA annealing and strand displacement: a FRET-based microplate reader assay for RNA chaperone activity Dissecting RNA chaperone activity An RNA chaperone activity of non-specific RNA binding proteins in hammerhead ribozyme catalysis RNA chaperone activity of large ribosomal subunit proteins from Escherichia coli RNA chaperone activity of protein components of human Ro RNPs Assaying RNA chaperone activity in vivo in bacteria using a ribozyme folding trap Escherichia coli CspA-family RNA chaperones are transcription antiterminators Transcription antitermination by translation initiation factor IF1 Assay of transcription antitermination by proteins of the CspA family RNA chaperones, RNA annealers and RNA helicases Protein enhancement of hammerhead ribozyme catalysis Identification and characterization of the RNA chaperone activity of hepatitis delta antigen peptides The hepatitis C virus Core protein is a potent nucleic acid chaperone that directs dimerization of the viral (+) strand RNA in vitro RNA chaperoning and intrinsic disorder in the core proteins of Flaviviridae Role of RNA chaperones in virus replication Coronavirus nucleocapsid protein is an RNA chaperone Coronavirus nucleocapsid protein facilitates template switching and is required for efficient transcription Assaying RNA chaperone activity in vivo using a novel RNA folding trap Assays for the RNA chaperone activity of proteins RNA chaperone StpA loosens interactions of the tertiary structure in the td group I intron in vivo The role of structural disorder in the function of RNA and protein chaperones How common are extraribosomal functions of ribosomal proteins? Recently, it was demonstrated that E. coli ribosomal proteins L15, L16, L18, and L19, that showed RNA chaperone activity in vitro, further possess protein chaperone activity comparable to other protein chaperones such as Hsp90 [43] . keywords: activity; annealing; assay; chaperone; chaperone activity; folding; group; intron; proteins; ribosomal; rna; splicing; structure; vivo cache: cord-342634-4ouhdjsr.txt plain text: cord-342634-4ouhdjsr.txt item: #104 of 112 id: cord-344902-bittqpyo author: Scott, Jennifer title: A systematic review of the physical activity levels of acutely ill older adults in Hospital At Home settings: an under-researched field date: 2020-10-15 words: 4910 flesch: 37 summary: Physical activity as step count Eight studies used pedometers or accelerometers to record 24 h step count as a measure of physical activity ( Functional change between admission and discharge was reported in 4 studies, the results extracted are summarised in Table 5 . The physical activity outcomes of the studies were grouped according to their method of measuring physical activity levels and reporting format. keywords: activity; acute; hah; home; hospital; levels; patients; research; results; review; studies cache: cord-344902-bittqpyo.txt plain text: cord-344902-bittqpyo.txt item: #105 of 112 id: cord-345695-5vi9wibk author: Hicks, Lorin L. title: A statistical approach to white-nose syndrome surveillance monitoring using acoustic data date: 2020-10-22 words: 5499 flesch: 44 summary: We developed a simple and repeatable statistical modeling approach for WNS surveillance monitoring with bat activity data collected from a broad geographic and temporal scale prior to known occurrence of WNS in the Intermountain West. We investigated relationships among bat activity, ambient temperatures, and season prior to presence of WNS across forested sites of Montana, USA where WNS was not known to occur. keywords: activity; bat; bats; data; forest; model; monitoring; north; sites; species; temperature; winter; wns; year cache: cord-345695-5vi9wibk.txt plain text: cord-345695-5vi9wibk.txt item: #106 of 112 id: cord-346060-ns6v76rb author: degli Espinosa, Francesca title: A Model of Support for Families of Children With Autism Living in the COVID-19 Lockdown: Lessons From Italy date: 2020-06-02 words: 6488 flesch: 46 summary: key: cord-346060-ns6v76rb authors: degli Espinosa, Francesca; Metko, Alma; Raimondi, Marta; Impenna, Michele; Scognamiglio, Elena title: A Model of Support for Families of Children With Autism Living in the COVID-19 Lockdown: Lessons From Italy date: 2020-06-02 journal: Behav Anal Pract DOI: 10.1007/s40617-020-00438-7 sha: doc_id: 346060 cord_uid: ns6v76rb Italy has been the European country most affected by the COVID-19 pandemic to date and has been in social lockdown for the longest period of time compared to other countries outside China. At the time of this writing, the Italian authorities have yet to provide statewide guidelines or funding for the continuation of intervention (ABA and non-ABA) via telehealth for children with autism during the lockdown period. keywords: activities; autism; behavior; children; day; families; parents; reinforcement; time; token cache: cord-346060-ns6v76rb.txt plain text: cord-346060-ns6v76rb.txt item: #107 of 112 id: cord-351932-dn60t7qa author: Salehi, Bahare title: Dioscorea Plants: A Genus Rich in Vital Nutra-pharmaceuticals-A Review date: 2019 words: 9790 flesch: 29 summary: Dioscorea alata L. Dioscorea alata L. is one of the most popular varieties of yams. The study revealed that the anti-MI mechanism of Dioscorea saponins is related not only to the enzymatic antioxidant, such as GPx and CAT but also to nonenzymatic antioxidants and its effect on myocardial histology (87) . keywords: activities; activity; antioxidant; cells; compounds; dioscorea; effect; extract; food; inflammatory; mice; nipponica; potential; rhizomes; saponins; species; steroidal; study; treatment; tubers; yam cache: cord-351932-dn60t7qa.txt plain text: cord-351932-dn60t7qa.txt item: #108 of 112 id: cord-352668-qjlqsb2k author: Cabello, Francisco title: Consensus on Recommendations for Safe Sexual Activity during the COVID-19 Coronavirus Pandemic date: 2020-07-20 words: 4842 flesch: 37 summary: Possible pharmaceutical and behavioral approaches Sexual function and depressive symptoms among male North American medical students Intimacy and belonging: The association between sexual activity and depression among older adults Factors associated with sexual health and well being in older adulthood Feeling Good is Good for you: How Pleasure Can Boost Your Immune System and Lengthen Your Life Sex for the mature adult: Health, self-esteem and countering ageist stereotypes Secrets of the Super Young Is good sex good for you? In all other cases (for those under quarantine, those with some clinical symptoms, health professionals in contact with COVID-19 patients, and during pregnancy), abstaining from coital/oral/anal sex, substituting it with masturbatory or virtual sexual activity to provide maximum protection from the contagion, and increasing the benefits inherent to sexual activity are recommended. keywords: activity; cov-2; covid-19; days; health; pandemic; partner; risk; sars; sex cache: cord-352668-qjlqsb2k.txt plain text: cord-352668-qjlqsb2k.txt item: #109 of 112 id: cord-352844-wggg3ynb author: Annunziata, Francesca title: An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities date: 2020-06-29 words: 51219 flesch: 38 summary: The resulting effect was expected to be a higher maximum collapse temperature and a faster synthesis of coumarin compounds by Knoevenagel reaction. The resulting effect was expected to be a higher maximum collapse temperature and a faster synthesis of coumarin compounds by Knoevenagel reaction. keywords: acid; activities; activity; antibacterial; antifungal; antioxidant activity; cancer; catalyst; cells; collaborators; complexes; compounds; coumarin; coumarin compounds; coumarin derivatives; detection; drug; effect; figure; fluorescent; group; human; ic50; inhibition; inhibitors; ions; novel; order; potential; probe; properties; reaction; reference; results; series; solvent; studies; synthesis; triazole; values; vitro; workers cache: cord-352844-wggg3ynb.txt plain text: cord-352844-wggg3ynb.txt item: #110 of 112 id: cord-353815-w35spqqt author: Huan, Yuchen title: Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields date: 2020-10-16 words: 12289 flesch: 27 summary: Archiv Activity and characterization of a pH-sensitive antimicrobial peptide Influence of pH on the activity of thrombin-derived antimicrobial peptides Effects of antimicrobial peptides on growth performance and small intestinal function in broilers under chronic heat stress Grouper (Epinephelus coioides) antimicrobial peptide epinecidin-1 exhibits antiviral activity against foot-andmouth disease virus in vitro A cancer vaccine based on the marine antimicrobial peptide pardaxin (GE33) for control of bladder-associated tumors Acquired resistance to the rice blast in transgenic rice accumulating the antimicrobial peptide thanatin Characterization and antimicrobial evaluation of SpPR-AMP1, a proline-rich antimicrobial peptide from the mud crab The vast structural diversity of antimicrobial peptides Predicting the minimal inhibitory concentration for antimicrobial peptides with rana-box domain The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding Conformational fine-tuning of pore-forming peptide potency and selectivity Gain-of-function analogues of the pore-forming peptide melittin selected by orthogonal high-throughput screening Comparative analysis of two attacin genes from Hyphantria cunea The human anionic antimicrobial peptide dermcidin induces proteolytic defence mechanisms in Staphylococci Antimicrobial peptides: possible anti-infective agents Dalbavancin and telavancin in the treatment of infective endocarditis: a literature review Antimicrobial peptides: application informed by evolution Transcriptome analysis of Streptococcus pneumoniae treated with the designed antimicrobial peptides Intracellular targeting mechanisms by antimicrobial peptides Diptericinlike protein: an immune response gene regulated by the anti-bacterial gene induction pathway in drosophila De novo generation of short antimicrobial peptides with simple amino acid composition The antimicrobial peptides and their potential clinical applications Exploring small cationic peptides of different origin as potential antimicrobial agents in aquaculture Interactions of the antimicrobial peptide nisin Z with conventional antibiotics and the use of nanostructured lipid carriers to enhance antimicrobial activity Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus Membrane active antimicrobial peptides: translating mechanistic insights to design Mechanism of antifungal activity of antimicrobial peptide APP, a cell-penetrating peptide derivative, against Candida albicans: intracellular DNA binding and cell cycle arrest Membrane interactions of proline-rich antimicrobial peptide, Chex1-Arg20, multimers Effects of the peptide H-OOWW-NH2 and its derived lipopeptide C12-OOWW-NH2 on controlling of citrus postharvest green mold Implicit membrane investigation of the stability of antimicrobial peptide β-barrels and arcs Control of sour rot in citrus fruit by three insect antimicrobial peptides Effects of rabbit sacculus rotundus antimicrobial peptides on the intestinal mucosal immunity in chickens Effect of an antifungal peptide from oyster enzymatic hydrolysates for control of gray mold (Botrytis cinerea) on harvested strawberries Biological activity and structural aspects of PGLa interaction with membrane mimetic systems Membrane pore-formation correlates with the hydrophilic angle of histidine-rich amphipathic peptides with multiple biological activities The first antimicrobial peptide from sea amphibian Regulation of cell division in E. coli Antimicrobial packaging based on ε-polylysine bioactive film for the control of mycotoxigenic fungi in vitro and in bread Nucleation and growth of pores in 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) / cholesterol bilayer by antimicrobial peptides melittin, its mutants and cecropin P1 In vitro and MD simulation study to explore physicochemical parameters for antibacterial peptide to become potent anticancer peptide Antimicrobial peptides of the vaginal innate immunity and their role in the fight against sexually transmitted diseases The value of antimicrobial peptides in the age of resistance Influence of self-assembly on the performance of antimicrobial peptides Kappacin, a novel antibacterial peptide from bovine milk Temporins, small antimicrobial peptides with leishmanicidal activity The host antimicrobial peptide Bac71-35 binds to bacterial ribosomal proteins and inhibits protein synthesis keywords: acid; activity; amino; amps; antibacterial; application; binding; cationic; cell; design; effect; et al; example; food; gram; human; inhibit; mechanism; membrane; motif; peptides; potential; properties; protein; research; residues; resistance; structure; virus cache: cord-353815-w35spqqt.txt plain text: cord-353815-w35spqqt.txt item: #111 of 112 id: cord-354044-3ugc7odq author: Salazar-Gómez, Anuar title: The potential role of sesquiterpene lactones isolated from medicinal plants in the treatment of the metabolic syndrome – A review date: 2020-09-16 words: 9409 flesch: 29 summary: Normalization of blood pressure Hong et al., 1999 Hong et al., , 2005 Reduction (#); increment (); thiobarbituric acid reactive substances (TBARS); reduced glutathione (GSH); superoxide dismutase (SOD); catalase (CAT); glutathione peroxidase (GPx); insulin resistance (IR); Toll-like receptor 4 (TLR4); c-Jun N-terminal kinases (JNK); interleukin 6 (IL-6); monocyte chemoattractant protein 1 (MCP-1); Apolipoprotein C3 (APOC3); AMP-activated protein kinase (AMPK); peroxisome proliferator-activated receptors a and g (PPARa/g); nuclear factor kappa B (NF-kB); transforming growth factor beta (TGF-b1); fibronectin (FN); glucose-6-phosphatase (G6Pase); glucokinase (GK); cyclooxygenase 2 (COX-2); interferon-gamma (IFN-g); tumor necrosis factor a (TNF-a); angiotensin I-converting enzyme (ACE). The guaianolide cumambrin A (21) (Fig. 2) , isolated from Chrysanthemum boreale (Makino) Makino, has shown a pharmacological effect on the normalization of blood pressure in spontaneously hypertensive rats (Hong et al., 1999) . keywords: activity; anti; blood; cells; compounds; diabetes; effects; et al; glucose; inhibition; insulin; lactone; levels; mets; rats; sesquiterpene; slns; studies; syndrome; toxicity; treatment cache: cord-354044-3ugc7odq.txt plain text: cord-354044-3ugc7odq.txt item: #112 of 112 id: cord-356062-7q5n4t97 author: None title: Cumulative pharmacological activity index volumes 1-30 date: 2005-12-31 words: 6484 flesch: -24 summary: 29:99 activity in EBV assay system 29:99 11, 15, activity in EBV assay system 29:99 Abieta-8,11,13-triene-7o~,l Human melanoma 23:255 Human mesangial cell proliferation 30:308 in vitro Human monoblastic leukemia cells 30:498 effect of hydroxyurea (HU) 30:498 growth inhibition of 30:498 Human monoblastic leukemia U937 cells 30:498 growth inhibition of Human neuroblastoma nbla-N-5 cells tamoxifen activity against 12:390 Human neuroblastoma SH-SY-5Y cells 12:390 Human neutrophils 12:390 Human neutropil protein kinase C 12:389 Human onchocerciasis 12:9 ivermectin for Human papilloma virus 30:394 pathogenesis of 30:394 cause of hepatocellular carcinoma Human Papilloma virus (HPV) 23:97 Human papilloma virus type 11 30:406 microbicidal compound against Human papilloma virus type 40 30:406 microbicidal compound against 30:406 Human platelets 12:390 study of protein kinase C in 12:390 by staurosporine 12:390 Human rotavirus (HRV) 30:406,412 cause of dehydrating gastroenteritis 30:406 member of 30:406 reoviridae type of Human serotonin transporter gene (SLC6A4) 30:376 regulation of neuronal activity Human spermatozoa motility 21:675 Human synovial PLA2 25:697 inhibitor anti-glycemic effects 24:902-904 anti-hyperglycemic effects of -O-methyl-20-hydroxyecdysone activity in 29:28 pinnatasterone activity in 29:28 polypodine B 2-O-cinnamate activity in Muscarinic AchR antagonists 21:56 Muscarinic antagonist 22:19 Muscarinic receptor 21:95 Muscarinic receptor antagonists 22:734 Muscarinic-l,2-receptor 21:95 Muscle pain 24:898 aconitine for relieving activation effects of 24:906 medicinal uses of 24:906 protein kinase C activation effects 24:906 Muscular P-388 (murine lymphocytic leukemia) 30:588 activity of (-)-deoxypodophyllotoxin against 30:588 activity of (-)-yatein against P-388 lymphocytic leukemia cell 25:764 keywords: 29:720; 30:589; 30:815; acid; activity; agent; antitumor; assay system; bioassay; cell; ebv; effects; human; inhibitor; kinase; nh2; properties; protease; protein; receptor; role; type; tyr; use; virus cache: cord-356062-7q5n4t97.txt plain text: cord-356062-7q5n4t97.txt