item: #1 of 116 id: cord-001262-8s7g2wvd author: Zheng, Guoping title: Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study date: 2014-04-04 words: 4927 flesch: 46 summary: The acute respiratory distress syndrome Acute respiratory distress syndrome: epidemiology and management approaches Mesenchymal stem cells: a promising therapy for the acute respiratory distress syndrome Co-infusion of ex vivo-expanded, parental MSCs prevents life-threatening acute GVHD, but does not reduce the risk of graft failure in pediatric patients undergoing allogeneic umbilical cord blood transplantation A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction Double allogenic mesenchymal stem cells transplantations could not enhance therapeutic effect compared with single transplantation in systemic lupus erythematosus Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn's disease: results from a multicenter phase I/IIa clinical trial Age-related decline in the osteogenic potential of human bone marrow cells cultured in three-dimensional collagen sponges Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells Human bone marrow and adipose tissue mesenchymal stem cells: a user's guide Bone marrow-derived mesenchymal stem cells in repair of the injured lung Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1 Autologous transplantation of adipose-derived mesenchymal stem cells markedly reduced acute ischemia-reperfusion lung injury in a rodent model Human mesenchymal stem cells overexpressing the IL-33 antagonist sST2 attenuate endotoxin-induced acute lung injury Systemic human orbital fat-derived stem/stromal cell transplantation ameliorates acute inflammation in lipopolysaccharide-induced acute lung injury Acute respiratory distress syndrome: the Berlin Definition Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome: The acute respiratory distress syndrome network Nichol AD: A randomised controlled trial of an open lung strategy with staircase recruitment, titrated PEEP and targeted low airway pressures in patients with acute respiratory distress syndrome Bronchoalveolar and systemic cytokine profiles in patients with ARDS, severe pneumonia and cardiogenic pulmonary oedema Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials Network NARDSCT: lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury National heart L, blood institute acute respiratory distress syndrome clinical trials N: pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury Acute respiratory distress syndrome N: plasma surfactant protein levels and clinical outcomes in patients with acute lung injury Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect A placebo-controlled, randomized trial of mesenchymal stem cells in COPD Cytological and enzymological characterization of adult human adipocyte precursors in culture Multilineage cells from human adipose tissue: implications for cell-based therapies Mesenchymal stromal cells Adipose-derived mesenchymal stromal cells for chronic myocardial ischemia (MyStromalCell Trial): study design Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease Adipose tissue-derived mesenchymal stem cells are more potent suppressors of dendritic cells differentiation compared to bone marrow-derived mesenchymal stem cells Direct comparison of human mesenchymal stem cells derived from adipose tissues and bone marrow in mediating neovascularization in response to vascular ischemia Cotransplantation of adipose tissue-derived insulin-secreting mesenchymal stem cells and hematopoietic stem cells: a novel therapy for insulin-dependent diabetes mellitus Favorable response to human adipose tissue-derived mesenchymal stem cells in steroid-refractory acute graft-versus-host disease N-glycolylneuraminic acid xenoantigen contamination of human embryonic and mesenchymal stem cells is substantially reversible No alloantibodies against mesenchymal stromal cells, but presence of anti-fetal calf serum antibodies, after transplantation in allogeneic hematopoietic stem cell recipients Platelet lysate from whole blood-derived pooled platelet concentrates and apheresis-derived platelet concentrates for the isolation and expansion of human bone marrow mesenchymal stromal cells: production process, content and identification of active components Autologous serum for isolation and expansion of human mesenchymal stem cells for clinical use In vitro expansion of human mesenchymal stem cells: choice of serum is a determinant of cell proliferation, differentiation, gene expression, and transcriptome stability Development of fully defined xeno-free culture system for the preparation and propagation of cell therapy-compliant human adipose stem cells Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • keywords: acute; adipose; ards; cells; day; injury; lung; mesenchymal; mscs; patients; stem; study cache: cord-001262-8s7g2wvd.txt plain text: cord-001262-8s7g2wvd.txt item: #2 of 116 id: cord-001493-3yu2di1g author: Fujishima, Seitaro title: Pathophysiology and biomarkers of acute respiratory distress syndrome date: 2014-05-07 words: 3099 flesch: 31 summary: In the revised Berlin definition, the term ARDS was redefined as a broader concept including a milder condition of lung injury; therefore, it became equivalent to acute lung injury (ALI), which was the previous AECC definition. Persistent elevation over time predicts poor outcome Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials National Heart Blood, and Lung Institute Acute Respiratory Distress Syndrome Network: Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury Vascular endothelial growth factor in epithelial lining fluid of patients with acute respiratory distress syndrome Keratinocyte growth factor and hepatocyte growth factor in bronchoalveolar lavage fluid in acute respiratory distress syndrome patients Growth differentiation factor-15 and prognosis in acute respiratory distress syndrome: a retrospective cohort study Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients Neutrophil elastase and systemic inflammatory response syndrome in the initiation and development of acute lung injury among critically ill patients Role of diabetes in the development of acute respiratory distress syndrome* Diabetes, insulin, and development of acute lung injury Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferatoractivated receptor-{gamma} Hartl D: CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation DNA and inflammatory mediators in bronchoalveolar lavage fluid from children with acute inhalational injuries Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury Soluble form of P-selectin in plasma is elevated in acute lung injury Elevated plasma surfactant protein-B predicts development of acute respiratory distress syndrome in patients with acute respiratory failure Acute Respiratory Distress Syndrome Network: keywords: acute; ards; biomarkers; injury; levels; lung; patients; respiratory cache: cord-001493-3yu2di1g.txt plain text: cord-001493-3yu2di1g.txt item: #3 of 116 id: cord-002016-vzn338ub author: Thompson, B. Taylor title: Steroids are part of rescue therapy in ARDS patients with refractory hypoxemia: no date: 2016-02-16 words: 1258 flesch: 27 summary: key: cord-002016-vzn338ub authors: Thompson, B. Taylor; Ranieri, V. Marco title: Steroids are part of rescue therapy in ARDS patients with refractory hypoxemia: no date: 2016-02-16 journal: Intensive Care Med DOI: 10.1007/s00134-016-4255-1 sha: doc_id: 2016 cord_uid: vzn338ub nan Rescue therapies for acute respiratory distress syndrome (ARDS) usually target patients with severe hypoxia and/ or hypercarbia refractory to conventional therapies and are considered when rapid deterioration in the patient's condition over a period of hours suggests an increased risk of death. Under these circumstances conventional mechanical ventilation will almost certainly cause additional lung injury if rescue therapies are not implemented. keywords: ards; corticosteroids; patients; rescue cache: cord-002016-vzn338ub.txt plain text: cord-002016-vzn338ub.txt item: #4 of 116 id: cord-005814-ak5pq312 author: None title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 words: 179325 flesch: 51 summary: Leukemia inhibitory factor (LIF), a growth factor recently recognised as a polyfunctional cytokine integrated in cytokine networks was measured in unconcentrated BALF of patients from different patient groups. It is difficult to generalize on intensive care units as different patient groups are in different ICUs aud there are great changes from one hospital to another and from one country to another. keywords: activity; acute; administration; admission; adult patients; age; aim; airway; analysis; apache; application; ards patients; arf; arterial; artery; assess; average; baseline; blood; blood flow; blood pressure; blood volume; breathing; cardiac; care patients; care unit; cases; catheter; cerebral; changes; chest; children; clinical; compliance; complications; concentration; conclusions; conditions; constant; control group; control patients; copd patients; correlation; course; cpb; criteria; critical; cvp; daily; damage; data; days; death; death patients; decrease; diagnosis; difference; disease; dose; drugs; duration; dysfunction; effect; emergency; end; evaluation; exchange; factors; failure; failure patients; findings; flow; fluid; following; frequency; function; gas; gastric; general; good; group; group b; group ii; group patients; h20; head; heart; hemodynamic; hepatic; hospital; hours; hypertension; icp; icu patients; iii; ill; illness; improvement; incidence; increase; index; infection; influence; infusion; injury; intensive; introduction; intubation; lactate; left; levels; life; liver; lung; male; management; map; mean; measurements; median; medical; methods; min; minutes; mmhg; model; monitoring; mortality; mortality rate; muscle; myocardial; need; negative; new; non; normal; number; objectives; onset; operation; order; organ; outcome; output; oxygen; oxygenation; p =; p<0.05; pao2; parameters; patients; patients methods; pattern; peep; perfusion; period; phase; phi; plasma; population; position; postoperative; presence; present; pressure; pressure support; procedure; protocol; pts; pulmonary; rain; range; rate; rats; reduction; renal; resistance; respiratory; response; results; right; risk; risk patients; samples; saps; score; sepsis; septic; serum; severe; severity; shock; shock patients; signs; specific; standard; status; stay; studies; study; study group; study period; subjects; support; surgery patients; surgical; survival; survivors; syndrome; system; systemic; technique; temperature; test; therapeutic; therapy; time; tissue; total; tracheal; transplantation; trauma patients; treatment; tube; type; unit; university; use; values; variables; vascular; vein; venous; ventilation; ventricular; volume; weaning; years cache: cord-005814-ak5pq312.txt plain text: cord-005814-ak5pq312.txt item: #5 of 116 id: cord-005884-uzxaey5k author: Lehner, G.F. title: Monitoring von Organfunktionen: Dysfunktion von Niere, Leber, Gastrointestinaltrakt und Gerinnung date: 2012-02-02 words: 3489 flesch: 36 summary: Im Jahr 2004 wurden von der Acute Dialysis Quality Initiative (ADQI) die sog. Der Einsatz der genannten Biomarker bei der klinischen Diagnose und der Klassifizierung der akuten Nierenschädigung könnte in Zukunft sowohl das frühere Erkennen einer Nierenfunktionsbeeinträchtigung ermöglichen und durch den dar-aus resultierenden früheren Behandlungsbeginn die Therapie optimieren als auch die Sensitivität und Spezifität der existierenden Systeme (RIFLE, AKIN) keywords: acute; als; auch; auf; bei; biomarkers; care; das; der; des; die; durch; eine; failure; für; gfr; icu; injury; ist; kidney; mit; monitoring; nicht; oder; patienten; score; serum; sind; und; von; werden; wie; zur cache: cord-005884-uzxaey5k.txt plain text: cord-005884-uzxaey5k.txt item: #6 of 116 id: cord-005892-3yuznrdv author: Hübener, P. title: Das akut-auf-chronische Leberversagen als diagnostische und therapeutische Herausforderung der Intensivmedizin date: 2017-02-16 words: 2155 flesch: 22 summary: The inflammatory response and immune function Acute-on-chronic liver failure: A new syndrome that will re-classify cirrhosis Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis Tumor necrosis factor alpha and interleukin 6 plasma levels in infected cirrhotic patients Pathophysiological effects of albumin dialysis in acute-on-chronic liver failure: A randomized controlled study Patients with acute on chronic liver failure display sepsis-like immune paralysis Short-term prognosis of community-acquired bacteremia in patients with liver cirrhosis or alcoholism: A population-based cohort study Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study Infections in patients with cirrhosis increase mortality fourfold and should be used in determining prognosis ClinicalCourseofacuteon-chronic liver failure syndrome and effects on prognosis Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure Acute-on-chronic liver failure: Consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis Prednisolone or Pentoxifylline for Alcoholic Hepatitis Management of critically-ill cirrhotic patients Intensive care of the patient with cirrhosis Acute-on-chronic liver failure before liver transplantation: Impact on posttransplant outcomes Acute-onchronic liver failure: Excellent outcomes after liver transplantation but high mortality on the wait list Acute-on-chronic liver failure: Terminology, mechanisms and management Bacterialinfectionsincirrhosis: A position statement based on the EASL Special Conference Management of acute-on-chronic liver failure Transfusion strategies for acute upper gastrointestinal bleeding Albumin for bacterial infections other than spontaneous bacterial peritonitis in cirrhosis. Liver failure · Cirrhosis · Infection · Organ failure · Transplantation Acute-on chronic liver failure Acute-on-chronic liver failure Toward an improved definition of acute-on-chronic liver failure Survival in infectionrelated acute-on-chronic liver failure is defined by extrahepatic organ failures Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis Lessons from look-back in acute liver failure? keywords: aclf; acute; bei; cirrhosis; das; der; des; die; eine; failure; liver; mit; oder; patients; und; von cache: cord-005892-3yuznrdv.txt plain text: cord-005892-3yuznrdv.txt item: #7 of 116 id: cord-005949-8po9xe5g author: Streetz, K.L. title: Akutes Leberversagen: Übersicht zur aktuellen Diagnostik und Therapie date: 2013-11-06 words: 1382 flesch: 37 summary: A report from the European Liver Transplant Registry (ELTR) Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-onchronic liver failure: the RELIEF trial Population-based surveillance for acute liver failure Acute liver failure: a life-threatening disease Liver transplantation for acute liver failure in Europe: outcomes over 20 years from the ELTR database Etiologies and outcomes of acute liver failure in Germany Usefulness of corticosteroids for the treatment of severe and fulminant forms of autoimmune hepatitis Effects of fractionated plasma separation and adsorption on survival in patients with acute-on-chronic liver failure Acute liver failure: summary of a workshop Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States Development of an accurate index for predicting outcomes of patients with acute liver failure Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations Management of severe acute to fulminant hepatitis B: to treat or not to treat or when to treat? Med Klin Intensivmed Notfmed DOI: 10.1007/s00063-013-0285-4 sha: doc_id: 5949 cord_uid: 8po9xe5g Although acute liver failure is a rare disease with a prevalence of 5 per 1 million people, it has a considerablely high mortality rate of 34 %. keywords: acute; alv; der; des; die; durch; einer; failure; liver; mit; und; von cache: cord-005949-8po9xe5g.txt plain text: cord-005949-8po9xe5g.txt item: #8 of 116 id: cord-006172-ndmf5ekp author: Akins, Paul Taylor title: H1N1 Encephalitis with Malignant Edema and Review of Neurologic Complications from Influenza date: 2010-09-02 words: 5008 flesch: 35 summary: 1918 influenza, encephalitis lethargica, parkinsonism Neuropathogenesis of influenza virus infection in mice PCR on cerebrospinal fluid to show influenza associated acute encephalopathy or encephalitis Detection of influenza virus RNA by reverse-transcription-PCR and proinflammatory cytokines in influenza-associated encephalopathy Acute encephalopathy associated with influenza A virus infection Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza Acute encephalopathy associated with influenza A infection in adults Systemic cytokine responses in patients with influenza-associated encephalopathy Cytokine profiles induced by the novel swine origin Influenza A/H1N1 virus: Implications for treatment strategies Tumor necrosis factor-a, Interleukin-1b, and interleukin-6 in cerebrospinal fluid from children with prolonged febrile seizures. The emerging hypothesis about acute neurologic complications of seasonal influenza is that the immune response triggered by influenza virus infection of the respiratory tract plays a prominent role in the pathogenesis of neurological manifestations. keywords: acute; brain; case; complications; csf; edema; encephalitis; encephalopathy; h1n1; infection; influenza; patients; virus cache: cord-006172-ndmf5ekp.txt plain text: cord-006172-ndmf5ekp.txt item: #9 of 116 id: cord-006508-rje9bnph author: Ballas, Samir K. title: Sickle Cell Anaemia: Progress in Pathogenesis and Treatment date: 2012-10-10 words: 14708 flesch: 42 summary: Five years of experience with hydroxyurea in children and young adults with sickle cell disease Clinical evaluation of a semi-permeable polymeric membrane dressing for the treatment of chronic diabetic foot ulcers Core decompression in avascular necrosis of the hip in sickle cell disease Long term results of total hip arthroplasty for osteonecrosis of the femoral head: a comparison with osteoarthritis Osteonecrosis of the hip in sickle cell diseases Total replacement of the hip for avascular necrosis in sickle cell disease Cholecystectomy in sickle cell anemia patients: Perioperative outcome of 364 cases from the National Preoperative Transfusion Study Cholecystectomy in adult patients with sickle cell disease Influence of bilirubin uridine diphosphate-glucoronosyltransferase 1A promotor polymorphisms on serum bilirubin levels and cholelithiasis in children with sickle cell anemia Genetic determinants of jaundice and gallstones in haemoglobin E b-thalassemia Exchange transfusion in sickle cell intrahepatic cholestasis Bone marrow transplantation for sickle cell disease Successful related cord blood transplantation for hemoglobinopathies Unrelated placental umbilical cord blood cell (UCBC) transplantation in children with high-risk sickle cell disease (SCD) Successful cord blood transplantation for sickle cell anemia from a sibling who is human leukocyte antigen-identical: implications for comprehensive care Correction of sickle cell disease in transgenic mouse models by gene therapy Hydroxyurea exposure alters mouse testicular kinetics and sperm chromatin structure Comparison of teratogenic effects of aspirin and hydroxyurea in the Fischer 344 and Wistar strains Severe developmental malformations: malformations induced by urethane and hydroxyurea in the hamster Acute leukemia (AL), hydroxyurea (HO) and polycythemia vera (PV): an analysis of risk and the Polycythemia Vera Study Group Fetal haemoglobin variations following hydroxyurea treatment in patients with cyanotic congenital heart disease A short-term trial of burtyate to stimulate fetal-globin-gene expression in the bglobin disorders Fetal hemoglobin induction with butyric acid: efficacy and toxicity Isobutyramide therapy in patients with sickle cell anemia Increased fetal hemoglobin in patients receiving sodium 4-phenylbutyrate Increased fetal hemoglobin production in patients receiving valproic acid for epilepsy Stimulation of hemoglobin synthesis by erythropoietin in baboons Augmentation by erythropoietin of the fetal-hemoglobin response to hydroxyurea in sickle cell disease Granulocytosis causing sickle cell crisis Fatal sickle cell crisis after granulocyte colony-stimulating factor administration Granulocyte colony-stimulating factor-inducted sickle cell crisis and multiorgan dysfunction in a patient with compound heterozygous sickle cell b+ thalassemia Inhibition of Ca2+-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease Pulmonary hypertension in sickle cell disease and treatment with L-Carritine Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease Zileuton: a potential new treatment approach for acute chest syndrome Sickle cell anemia: a potential nutritional approach for a molecular disease Green tea extract and aged garlic extract inhibit potassium chloride co-transport in sickle cells in vitro, but Vitamin-C and Vitamin-E do not Hydration of sickle erythrocytes using a herbal extract (Pfaffia paniculata) in-vitro Department of Medicine, Cardeza Foundation for Hematologic Research Supported in part by the Sickle Cell Program of the Commonwealth of Pennsylvania, Harrisburg, Pennsylvania, USA. Basic principles and clinical picture Sickle cell anemia and major organ failure Beyond hemoglobin polymerization: The red blood cell membrane and sickle disease pathophysiology Vascular occlusion in sickle cell disease: Current concepts and unanswered questions Regulation of erythrocytes cation and water content in sickle cell anemia Cation transport and volume regulation in sickle red blood cells Prevention of red cell dehydration: a possible new treatment for sickle cell disease A mathematical model of the volume, pH1 and ion content regulation in reticulocytes: application to the pathophysiology of sickle cell dehydration Regulation of cation content and cell volume in hemoglobin erythrocytes from patients with homozygous hemoglobin C disease Inhibition of K transport by divalent cations in sickle erythrocytes Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease Compartmentation of sickle cell calcium in endocytic inside-out vesicles Compartmentation of Ca2+ in sickle cells Endocytosis in sickle erythrocytes: A mechanism for elevated intracellular Ca2+ levels Erythrocyte adherence to endothelium in sickle cell anemia: a possible determinant of disease severity Abnormal adherence of sickle cell erythrocytes to cultured vascular endothelium: possible mechanism for microvascular occlusion in sickle cell disease Adhesion of normal and sickle erythrocytes to endothelial monolayer cultures Rheological studies of erythrocyte-endothelial cell interactions in sickle cell disease Sickle cell vaso-occlusion In vivo demonstration of red cell-endothelial interaction, sickling and altered microvascular response to oxygen in the sickle transgenic mouse Microvascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: pathophysiological implications Adherence of sickle erythrocytes to vascular endothelial cells; requirement for both cell membrane changes and plasma factors Sickle reticulocytes adhere to VCAM-1 a4b1-integrin expression on sickle reticulocytes: vascular cell adhesion molecular-1-dependent binding to endothelium Platelet hyperactivity in sickle cell disease: a consequence of hyposplenism Significance of plasma beta-thromboglobulin values in patients with sickle cell disease Platelet activation during steady state sickle cell disease Phenomenology to function Thrombospondin mediates adherence of CD36+ sickle reticulocytes to endothelial cells Thrombospondin from activated platelets promotes sickle erythrocyte adherence to human microvascular endothelium under physiologic flow: a potential role for platelet activation in sickle cell vasoocclusion P-selectin mediates the adhesion of sickle erythrocytes to the endothelium Occlusion of large cerebral vessels in sickle cell anemia Sickle cell anemia and central nervous system infarction: a neuropathological study Hypofibronectinaemia and severity of sickle cell anaemia Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice Sickle cell anemia as an inflammatory disease Monoclonal antibodies to αvβ3 (7E3and LM609) inhibit sickle red blood cell endothelium interaction induced by platelet activating factor Blockade of adhesion of sickle cells to endothelium by monoclonal antibodies Thalassemia in blacks: genetic and clinical aspects and interactions with the sickle hemoglobin gene The Senegal DNA haplotype is associated with the amelioration of anemia in African-American sickle cell anemia patients Sickle cell anemia bs-gene-cluster haplotypes as prognostic indicators of vital organ failure Rheologic predictors of the severity of the painful sickle cell crisis The painful crisis of homozygous sickle cell disease: a study of risk factors Pain in sickle cell disease: rates and risk factors The prevalence of avascular necrosis in sickle cell anemia: correlation with athalassemia Sickle cell disease as a cause of osteonecrosis of the femoral head Leg ulcers in patients with sickle cell disease Alpha thalassemia and stroke risk in sickle cell anemia Is Hb A2 elevated in adults with sickle-α-thalassemia (Bs/Bs;-α/-α)? keywords: acute; adhesion; anemia; blood; cell; cell anaemia; cell disease; chest; children; disease; effect; gene; hydroxyurea; levels; management; non; opioid; pain; patients; rbc; sickle; sickle hb; syndrome; therapy; transfusion; treatment; use cache: cord-006508-rje9bnph.txt plain text: cord-006508-rje9bnph.txt item: #10 of 116 id: cord-007321-7gi6xrci author: Chow, Anthony W. title: Evaluation of New Anti-Infective Drugs for the Treatment of Respiratory Tract Infections date: 1992-11-17 words: 16092 flesch: 29 summary: In phase 2 and 3 trials, study patients should be stratified according to major host factors (e.g., history and duration of smoking). Clinical studies should include patients of different age groups, since the clinical manifestations of group A streptococcal pharyngitis and tonsillitis may vary with age of the patient. keywords: acute; aom; children; chronic; control; culture; days; diagnosis; drug; evaluation; failure; group; infection; microbiologic; pathogens; patients; pharyngitis; pneumonia; response; sinusitis; sputum; studies; study; symptoms; therapy; treatment cache: cord-007321-7gi6xrci.txt plain text: cord-007321-7gi6xrci.txt item: #11 of 116 id: cord-007444-c9vu8ako author: Sherk, Peter A. title: The Chronic Obstructive Pulmonary Disease Exacerbation date: 2000-12-01 words: 9175 flesch: 34 summary: They analyzed 362 admissions for acute COPD exacerbation from the APACHE I11 database. This airflow obstruction is generally progressive, may be accompanied by airway hyperreactivity, and often is partially re~ersible.~ Declining lung function is almost universally caused by decades of tobacco smoke exposure and develops insidiously so that patients often do not complain of exertional dyspnea until their 1-second forced expiratory volume (FEV,) is between 40% and 59% of its predicted value.20 When the FEV, falls below 1 L, patients are disabled in the activities of daily living and have a 5-year survival of approximately 50?!0. keywords: acute; aecopd; chronic; copd; disease; exacerbations; failure; infection; mortality; nppv; patients; pulmonary; respiratory; studies; study; therapy; treatment cache: cord-007444-c9vu8ako.txt plain text: cord-007444-c9vu8ako.txt item: #12 of 116 id: cord-007585-vs5yondw author: Dere, Willard H. title: Acute bronchitis: Results of U.S. and European trials of antibiotic therapy date: 1992-06-22 words: 2044 flesch: 41 summary: Loracarbef may be considered a safe and effective alternative agent for the treatment of patients with acute bronchitis. Patients with acute bronchitis that is suspected to be of viral origin are often treated with acetaminophen keywords: amoxicillin; bronchitis; loracarbef; patients cache: cord-007585-vs5yondw.txt plain text: cord-007585-vs5yondw.txt item: #13 of 116 id: cord-010945-6iisb8jw author: Khurana, Aman title: Reporting of acute pancreatitis by radiologists-time for a systematic change with structured reporting template date: 2020-03-18 words: 5729 flesch: 25 summary: A Dutch Observational Multicenter Study CT and MRI assessment of symptomatic organized pancreatic fluid collections and pancreatic duct disruption: an interreader variability study using the revised Atlanta classification 2012 Management and outcomes of acute pancreatitis patients over the last decade: A US tertiary-center experience Computed Tomographic Prognostic Factors for Predicting Local Complications in Patients With Pancreatic Necrosis Computed tomography severity index is a predictor of outcomes for severe pancreatitis Computed Tomography Severity Index vs. Other Indices in the Prediction of Severity and Mortality in Acute Pancreatitis: A Predictive Accuracy Metaanalysis Treatment of severe acute pancreatitis and its complications The Revised Atlanta Classification of Acute Pancreatitis: Its Importance for the Radiologist and Its Effect on Treatment Clinical utility of the Revised Atlanta Classification of acute pancreatitis in a prospective cohort: Have all loose ends been tied Significant interobserver variation in the diagnosis of extrapancreatic necrosis and type of pancreatic collections in acute pancreatitis -An international multicenter evaluation of the revised Atlanta classification RSNA Radiology Reporting Initiative -Reporting Wiki Electronic synoptic operative reporting: assessing the reliability and completeness of synoptic reports for pancreatic resection Improving Communication of Diagnostic Radiology Findings through Structured Reporting Structured reporting of multiphasic CT for pancreatic cancer: potential effect on staging and surgical planning Effect of a 19-item surgical safety checklist during urgent operations in a global patient population Checklists: from the cockpit to the radiology department Quality initiatives: lean approach to improving performance and efficiency in a radiology department Improving Consistency in Radiology Reporting through the Use of Department-wide Standardized Structured Reporting Necrotizing pancreatitis: a review of multidisciplinary management Disconnection of the pancreatic duct: an important but overlooked complication of severe acute pancreatitis Endoscopic transpapillary drainage in disconnected pancreatic duct syndrome after acute pancreatitis and trauma: long-term outcomes in 31 patients Peripancreatic collections in acute pancreatitis: Correlation between computerized tomography and operative findings Necrotizing Pancreatitis: Contemporary Analysis of 99 Consecutive Cases The authors had control of the data and the information submitted for publication. Further establishment of widespread terminology use and simple identification of complications could continue to improve pancreatitis templates [15] . keywords: acute; classification; collections; complications; imaging; necrosis; pancreatic; pancreatitis; peripancreatic; template cache: cord-010945-6iisb8jw.txt plain text: cord-010945-6iisb8jw.txt item: #14 of 116 id: cord-011192-h0omskec author: Uber, Amanda M. title: Acute kidney injury in hospitalized children: consequences and outcomes date: 2018-11-01 words: 4907 flesch: 46 summary: When reviewing AKI outcome studies, it is essential to interpret the data within the context of several general concepts. These two studies not only demonstrate the significance of AKI among newborns, they also highlight the influence that the patient population and severity of illness can have on AKI related outcomes. keywords: acute; aki; children; injury; kidney; outcomes; recovery; renal cache: cord-011192-h0omskec.txt plain text: cord-011192-h0omskec.txt item: #15 of 116 id: cord-014538-6a2pviol author: Kamilia, Chtara title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 words: 61107 flesch: 45 summary: We included ICU patients admitted for acute hypoxemic respiratory failure from a previous prospective trial [1] in whom FiO 2 was measured under oxygen mask using a portable oxygen analyzer. Introduction Relative adrenal insufficiency (RAI) is common in ICU patients, particularly during septic shock (1). keywords: acute; admission; adult patients; age; aim; analysis; ards patients; arrest; blood; cardiac; care; care unit; cases; cause; children; clinical; conclusion; criteria; data; days; diagnosis; discussion; disease; duration; extubation; factors; failure; fluid; group; hospital; icu; icu admission; icu mortality; icu patients; incidence; infection; injury; intensive; introduction; jean; low; lung; management; mean; mechanical; median; medical; methods; mortality; n =; niv; non; nutrition; occurrence; outcome; oxygen; p =; patients; period; pierre; pneumonia; pressure; pulmonary; rate; renal; results; risk; score; sepsis; shock; shock patients; significant; stay; studies; study; study period; support; syndrome; therapy; time; treatment; unit; use; vap; ventilation; weaning; years cache: cord-014538-6a2pviol.txt plain text: cord-014538-6a2pviol.txt item: #16 of 116 id: cord-015384-bz7ui5a0 author: Hans-Peter, Kapfhammer title: Posttraumatic stress disorder in survivors of acute respiratory distress syndrome (ARDS) and septic shock date: 2008-11-27 words: 2531 flesch: 24 summary: Zum Zeitpunkt der Entlassung von der Intensivstation hatten 43,5% dieser Patienten das Vollbild einer PTSD, 8,9% wiesen eine sub-PTSD auf. Als Risikofaktoren für die Entwicklung eines PTSD konnten nicht die Schwere der somatischen Erkrankung (APA-CHE II Score, Lung Injury Score), aber die Anzahl der Tage der intensivmedizinischen keywords: acute; ali; ards; auf; care; der; die; disorder; distress; doses; einer; nach; patienten; ptsd; stress; survivors; syndrome; und; von cache: cord-015384-bz7ui5a0.txt plain text: cord-015384-bz7ui5a0.txt item: #17 of 116 id: cord-015548-zjrkfe9b author: Popat, Bhavesh title: Invasive and non-invasive mechanical ventilation date: 2012-05-18 words: 3044 flesch: 18 summary: The use of noninvasive mechanical ventilation in COPD with severe hypercapnic acidosis NIPPV e NIV in Acute Respiratory Failure Guideline Non-invasive ventilation in acute respiratory failure Survival and quality of life for patients with COPD or asthma admitted to intensive care in a UK multicentre cohort: the COPD and Asthma Outcome Study (CAOS) Randomised controlled comparison of continuous positive airways pressure, bilevel non-invasive ventilation, and standard treatment in emergency department patients with acute cardiogenic pulmonary oedema Noninvasive pressure support ventilation vs. continuous positive airway pressure in acute hypercapnic pulmonary edema Non-invasive pressure support ventilation versus conventional oxygen therapy in acute cardiogenic pulmonary oedema: a randomised trial Noninvasive ventilation in patients with acute cardiogenic pulmonary edema Effect of non-invasive positive pressure ventilation (NIPPV) on mortality in patients with acute cardiogenic pulmonary oedema: a meta-analysis Noninvasive ventilation in acute cardiogenic pulmonary edema Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the task force on acute heart failure of the European Society of Cardiology A systematic review Failure of non-invasive ventilation in patients with acute lung injury: observational cohort study Noninvasive ventilation in severe hypoxemic respiratory failure: a randomized clinical trial Noninvasive ventilation for treatment undergoing solid organ transplantation Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure Noninvasive ventilation for treating acute respiratory failure in AIDS patients with Pneumocystis carinii pneumonia Use of non-invasive ventilation to wean critically ill adults off invasive ventilation: metaanalysis and systematic review Non-invasive positive pressure ventilation for treatment of respiratory failure due to severe acute exacerbations of asthma The use of non-invasive ventilation for life-threatening asthma attacks: changes in the need for intubation Overview of ventilator-induced lung injury mechanisms Cellular responses to mechanical Stress: invited review: mechanisms of ventilator-induced lung injury: a perspective Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. keywords: failure; niv; patients; pressure; support; use; ventilation cache: cord-015548-zjrkfe9b.txt plain text: cord-015548-zjrkfe9b.txt item: #18 of 116 id: cord-015957-vimq6qs7 author: Casillas, Javier title: Acute Pancreatitis (AP) date: 2015-03-31 words: 1422 flesch: 36 summary: Multidisciplinary Teaching Atlas of the Pancreas DOI: 10.1007/978-3-662-46745-9_14 sha: doc_id: 15957 cord_uid: vimq6qs7 All of these conditions can be associated with acute pancreatitis, except ? Acute pancreatitis defi nition: • Acute infl ammatory process of the pancreas with a wide range of manifestations and clinical variation, ranging from local infl ammation to systemic manifestations such as organ failure. The frequency of acute pancreatitis varies among different countries. keywords: acute; failure; organ; pancreatitis; patients cache: cord-015957-vimq6qs7.txt plain text: cord-015957-vimq6qs7.txt item: #19 of 116 id: cord-015985-lrzzak3l author: Marres, H. A. M. title: Keel-, neus-, oorziekten date: 2014-12-15 words: 20533 flesch: 50 summary: Beoordeling van de motoriek van iedere tak afzonderlijk en uitdrukken hiervan in een schaal (bijv. Degeneratie van het orgaan van Corti (verlies van haarcellen, degeneratieve veranderingen in de basilaire membraan), verdwijnen van zenuwcellen van het ganglion spirale en verlies van neuronen van het centraalakoestische systeem. keywords: aan; aan de; aan het; acute; aet; afhankelijk van; afwijkingen; algemeen; algemene; alleen; als; als bij; andere; antibiotica; audiometrie; beeld; beide; bij; bij de; bij het; bijv; carcinoom; chronische; combinatie; dan; dat; de gehoorgang; de neus; diagn; diff; dit; doofheid; door; door de; door het; duizeligheid; e en; een; en bij; en het; ernstige; eventueel; factoren; frequenties; geen; gehoorgang; gevolg van; het middenoor; het oor; het slijmvlies; het trommelvlies; hoortoestel; indien; infectie; kan; kinderen; kunnen; laryngitis; larynx; lichte; maligne; maxillaris; media; meer; meestal; men; middenoor; mogelijk; naar; neus; niet; normaal; nystagmus; onderdeel van; onderzoek; ontgenfoto; ontstaan; ontsteking; ook; oorsuizen; oorzaak; op de; op het; operatie; otitis; perceptieslechthorendheid; pijn; rinitis; scan; secundair; sinus; sinusitis; slechthorendheid; slijmvlies; soms; spraak; sympt; therapie; tonsillitis; tot; trauma; trommelvlies; tumor; tumoren; uit; uitval; uitval van; vaak; van acute; van de; van een; van het; verlies; verschijnselen; voor; vooral; vooral bij; vorm; waardoor; worden; wordt; zeer; zgn; zie; zijden; zijn; zoals; zwelling cache: cord-015985-lrzzak3l.txt plain text: cord-015985-lrzzak3l.txt item: #20 of 116 id: cord-016235-2lhrkmrv author: Roden, Anja C. title: Lung date: 2010-05-17 words: 12880 flesch: 33 summary: The effect of recipient's age on lung transplant outcome Pretransplant panel reactive antibody in lung transplant recipients is associated with significantly worse post-transplant survival in a multicenter study Gastroesophageal reflux disease in lung transplant recipients Lung homotransplantation in man Association of minimal rejection in lung transplant recipients with obliterative bronchiolitis Prospective analysis of 1, 235 transbronchial lung biopsies in lung transplant recipients Rejection is reduced in thoracic organ recipients when transplanted in the first year of life C4d deposition in lung allografts is associated with circulating anti-HLA alloantibody Acute and chronic onset of bronchiolitis obliterans syndrome (BOS): are they different entities? Anti-HLA class I antibody binding to airway epithelial cells induces production of fibrogenic growth factors and apoptotic cell death: a possible mechanism for bronchiolitis obliterans syndrome Pleural effusion from acute lung rejection Refining the identification of discriminatory genes for rejection in lung transplantation: the largo study Significance of a solitary perivascular mononuclear infiltrate in lung allograft recipients with mild acute cellular rejection Native lung complications in single-lung transplant recipients and the role of pneumonectomy Immunodeficiency-associated lymphoproliferative disorders Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplantation lymphoproliferative disorders The US experience with lung transplantation for pulmonary lymphangioleiomyomatosis The diagnosis of obliterative bronchiolitis after heart-lung and lung transplantation: low yield of transbronchial lung biopsy Clinical impact of community-acquired respiratory viruses on bronchiolitis obliterans after lung transplant Lung transplantation at Duke University Medical Center Pulmonary inflammation after lung transplantation The incidence of cancer in patients with idiopathic pulmonary fibrosis and sarcoidosis in the UK Posttransplant lymphoproliferative disorders not associated with Epstein-Barr virus: a distinct entity? Identification of prognostic factors in 61 patients with posttransplantation lymphoproliferative disorders Chronic aspiration of gastric fluid induces the development of obliterative bronchiolitis in rat lung transplants GI complications after orthotopic lung transplantation B-cell posttransplant lymphoproliferative disorders in heart and/or lungs recipients: clinical and molecular-histogenetic study of 17 cases from a single institution C3d and the septal microvasculature as a predictor of chronic lung allograft dysfunction Selection and evaluation of recipients for heart-lung and lung transplantation Outcomes of lung transplantation in patients with scleroderma Complications (excluding hyperinflation) involving the native lung after single-lung transplantation: incidence, radiologic features, and clinical importance Evolving strategies in lung transplantation for emphysema Surveillance bronchoscopy in lung transplant recipients: risk versus benefit Clinical implications and longitudinal alteration of peripheral blood transcriptional signals indicative of future cardiac allograft rejection Lung transplantation: a decade of experience Acute humoral rejection of human lung allografts and elevation of C4d in bronchoalveolar lavage fluid Lung transplantation for end-stage pulmonary sarcoidosis: outcome in a series of seven consecutive patients Pulmonary hypertension in patients with bronchiolitis obliterans syndrome listed for retransplantation Epstein-Barr virus-negative post-transplant lymphoproliferative disorders: a distinct entity? Lymphomas after solid organ transplantation: a collaborative transplant study report General overview of lung transplantation and review of organ allocation Development of an antibody specific to major histocompatibility antigens detectable by flow cytometry after lung transplant is associated with bronchiolitis obliterans syndrome Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation Bronchoalveolar lavage cell gene expression in acute lung rejection: development of a diagnostic classifier Lung transplantation for lymphangioleiomyomatosis The changing pattern of posttransplant malignancies Does human leukocyte antigen matching influence the outcome of lung transplantation? Several host genetic characteristics have been suggested to modulate acute lung rejection. keywords: acute; allograft; bronchiolitis; chronic; diagnosis; disease; grade; heart; hla; infection; injury; lung; lung transplantation; patients; posttransplantation; pulmonary; recipients; rejection; risk; study; transplantation; years cache: cord-016235-2lhrkmrv.txt plain text: cord-016235-2lhrkmrv.txt item: #21 of 116 id: cord-016526-obph3gup author: Degnan, Tina H. title: Appropriate Antibiotic Use for Treatment of Nonspecific Upper Respiratory Infections, Rhinosinusitis, and Acute Bronchitis in Adults date: 2007 words: 1979 flesch: 30 summary: Pneumonia is potentially the most serious diagnosis associated with acute cough illness and can be fairly accurately distinguished from acute bronchitis based on clinical examination findings. Lower respiratory tract viruses such as influenza A and B, parainfluenza 3, and RSV are the most common causes of acute bronchitis, but upper tract viruses such as coronavirus, adenovirus, and rhinovirus may also cause acute cough illness. keywords: adults; antibiotic; bronchitis; treatment cache: cord-016526-obph3gup.txt plain text: cord-016526-obph3gup.txt item: #22 of 116 id: cord-016539-jwm0s8gm author: Mishra, Ajay Kumar title: Acute Pancreatitis date: 2016-02-22 words: 1534 flesch: 43 summary: Classifi cation of acute pancreatitis -2012: revision of the Atlanta classifi cation and defi nitions by international consensus Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome The continuing challenge of early mortality in acute pancreatitis Fatal outcome in acute pancreatitis: its occurrence and early prediction Initial management of acute pancreatitis: critical issues during the fi rst 72 hours Detection of gallstones in acute pancreatitis: when and how? Clinical considerations and clues to diagnosis Epidemiology, natural history, and predictors of disease outcome in acute and chronic pancreatitis The revised Atlanta classifi cation for acute pancreatitis: updates in imaging terminology and guidelines Decreased mortality in acute pancreatitis related to early aggressive hydration Lactated Ringer's solution reduces systemic infl ammation compared with saline in patients with acute pancreatitis Emergency sedation and pain management Meta-analysis: total parenteral nutrition versus total enteral nutrition in predicted severe acute pancreatitis Present and future of prophylactic antibiotics for severe acute pancreatitis Is early endoscopic retrograde cholangiopancreatography useful in the management of acute biliary pancreatitis? • Revised Atlanta criteria 2013 (Table 27. 2 ) defi nes severity of acute pancreatitis into three categories -mild acute pancreatitis, moderately severe acute pancreatitis and severe acute pancreatitis [ 12 ] . keywords: acute; mortality; pancreatitis; patients cache: cord-016539-jwm0s8gm.txt plain text: cord-016539-jwm0s8gm.txt item: #23 of 116 id: cord-016557-f2mzwhrt author: Aggrawal, Anil title: Agrochemical Poisoning date: 2006 words: 18208 flesch: 47 summary: However, the hallmark of paraquat poisoning, especially when the victim has survived a few days, are the profound changes in lungs. Out of the 18 deaths caused by pesticides reported by the 2002 AAPCC annual report (15) , two were the result of paraquat poisoning. keywords: acid; activity; acute; agent; alp; autopsy; blood; bromide; cases; cause; chemicals; compounds; control; copper; death; e.g.; effects; exposure; fluoride; gas; herbicide; ingestion; insecticides; liver; lung; methyl; mixture; mucosa; organophosphorus; paraquat; paraquat poisoning; parathion; pesticides; poisoning; sodium; sulfate; toxicity; water; workers cache: cord-016557-f2mzwhrt.txt plain text: cord-016557-f2mzwhrt.txt item: #24 of 116 id: cord-016757-3d320c0a author: None title: Acute and chronic liver insufficiency date: 2008 words: 9789 flesch: 40 summary: Clinical features, etiology, epidemiology, and current management Serum phosphorus levels predict clinical outcome in fulminant hepatic failure Plasma phospholipids fatty acid pattern in severe liver disease Fulminant hepatic failure as a presenting paraneoplastic manifestation of Hodgkin's disease Controlled hyperventilation in the prevention of cerebral oedema in fulminant hepatic failure Prognostic indicators in acute liver failure Fulminant hepatic failure in nonmetastatic renal cell carcinoma Fulminant Epstein-Barr viral hepatitis: orthotopic liver transplantation and review of the literature Insulin and glucagon levels in fulminant hepatic failure in man Prognostic indicators in fulminant hepatic failure Insulin and Glucagon therapy of acute hepatic failure Miliary tuberculosis presenting as hepatic and renal failure Fulminant hepatic failure after occupational exposure to 2-nitropropane Chemotherapy of Amanita phalloides poisoning with intravenous silibinin Activin A and follistatin in acute liver failure Fulminant hepatic failure caused by tuberculosis Fulminant or subfulminant non-A, non-B viral hepatitis: the role of hepatitis C and E viruses Moderate hypothermia in patients with acute liver failure and uncontrolled intracranial hypertension Fulminant hepatic failure due to secondary amyloidosis Pilot study with polyenylphosphatidylcholine in severe liver insufficiency Controlled trial of antithrombin III supplementation in fulminant hepatic failure Intracranial pressure monitoring and liver transplantation for fulminant hepatic failure Ratio of circulating follistatin and activin A reflects the severity of acute liver injury and prognosis in patients with acute liver failure The fulminant form of epidemic hepatitis Fulminant hepatic failure as the initial manifestation of primary hepatocellular carcinoma Fulminant hepatic failure with massive necrosis as a result of hepatitis A infection Early changes in the permeability of the blood-brain barrier produced by toxins associated with liver failure Spontaneous reactivation of chronic hepatitis B infection leading to fulminant hepatic failure Hepatic regeneration in fulminant hepatic failure Renal failure in acute liver failure Caffeine clearance and galactose elimination capacity as prognostic indicators in fulminant hepatic failure Autoimmune hepatitis presenting with acute hepatic failure Fulminant hepatic failure caused by acute fatty liver of pregnancy treated by orthotopic liver transplantation Coagulation factor V and VIII/V ratio as predictors of outcome in paracetamol induced fulminant hepatic failure: relation to other prognostic indicators The management of abnormalities of hemostasis in acute liver failure Activation of the fibrinolytic system in patients with fulminant liver failure Vorgehen bei Knollenblätterpilzvergiftung Fulminant hepatic failure after Lepiota mushroom poisoning Bacterial and fungal infection in acute liver failure L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure Acute carbon tetrachloride poisoning in 19 patients: implications for diagnosis and treatment Selective intestinal decontamination in the prevention of bacterial infection in patients with acute liver failure Acute liver failure due to non-Hodgkin's lymphoma Efficacy of hepatic arterial infusion of prostaglandin E1 in the treatment of postoperative acute liver failure. Ϫ Report of a case Gc-globulin and prognosis in acute liver failure Energy metabolism in acute hepatic failure Prognostic value of hepatic volumetry in fulminant hepatic failure The pathophysiological basis of acuteon-chronic liver failure Variants of hepatitis B virus associated with fulminant liver disease Acute liver failure: clinical features, outcome analysis, and applicability of prognostic criteria Treatment of fulminant hepatic failure with intravenous prostaglandin E1 Brain edema in liver failure: basic physiologic principles and management Hyperventilation restores cerebral blood flow autoregulation in patients with acute liver failure Cerebral metabolism of ammonia and amino acids in patients with fulminant hepatic failure Prospective assessment of incidence of fulminant hepatitis in post-transfusion hepatitis: a study of 504 cases Fulminant hepatitis A virus infection in the United States: Incidence, prognosis, and outcomes Role of hepatitis C virus in German patients with fulminant and subfulminant hepatic failure Fulminante Hepatitis bei Listeriensepsis Fulminant herpes hepatitis in a healthy adult. keywords: acute; blood; cerebral; chronic; coma; disease; failure; function; hepatic; hepatitis; hepatocytes; insufficiency; liver; liver failure; patients; system; time; transplantation; treatment cache: cord-016757-3d320c0a.txt plain text: cord-016757-3d320c0a.txt item: #25 of 116 id: cord-016815-pva22xy7 author: Mannem, Hannah C. title: Transfusion and Acute Respiratory Distress Syndrome: Clinical Epidemiology, Diagnosis, Management, and Outcomes date: 2016-06-11 words: 5446 flesch: 45 summary: Reports as high as 67 % mortality have been shown in TRALI patients who were critically ill at the time of TRALI diagnosis; however, the cohorts utilized in these studies included some possible TRALI cases as well [ 14 , 16 , 32 ] . Clinical Epidemiology, Diagnosis, Management, and Outcomes date: 2016-06-11 journal: Hematologic Abnormalities and Acute Lung Syndromes DOI: 10.1007/978-3-319-41912-1_11 sha: doc_id: 16815 cord_uid: pva22xy7 Transfusion related acute lung injury (TRALI) is a life-threatening complication of blood product transfusion. keywords: acute; blood; injury; lung; patients; plasma; population; risk; trali; transfusion cache: cord-016815-pva22xy7.txt plain text: cord-016815-pva22xy7.txt item: #26 of 116 id: cord-017012-yl0vanuh author: Herberg, Jethro title: Infectious Diseases and the Kidney date: 2009 words: 23989 flesch: 30 summary: Bacterial infections associated with renal disease and the likely mechanisms causing renal dysfunction are shown in > Impaired renal function is a common occurrence in systemic sepsis (1) . The group A streptococci (GAS) are a major worldwide cause of renal disease, usually as poststreptococcal nephritis. keywords: acute; bkv; cases; cause; cells; children; chronic; diagnosis; disease; evidence; failure; features; fever; glomerular; hbv; hepatitis; hiv; illness; immune; infection; involvement; kidney; nephritis; nephropathy; patients; present; proteinuria; renal; shock; syndrome; therapy; treatment; urine; virus cache: cord-017012-yl0vanuh.txt plain text: cord-017012-yl0vanuh.txt item: #27 of 116 id: cord-017107-sg8n12hs author: Suri, H. S. title: Epidemiology of Acute Respiratory Failure and Mechanical Ventilation date: 2008 words: 4117 flesch: 38 summary: The burden of acute respiratory failure is high in terms of mortality and morbidity as well as the cost of its principal treatment, mechanical ventilation. Very few epidemiologic studies have evaluated the prevalence and outcome of acute respiratory failure and mechanical ventilation in general. keywords: acute; failure; hospital; lung; mortality; patients; study; ventilation cache: cord-017107-sg8n12hs.txt plain text: cord-017107-sg8n12hs.txt item: #28 of 116 id: cord-017126-7ebo3cy3 author: None title: Lungenversagen date: 2007 words: 4328 flesch: 25 summary: Die Hochfrequenzoszillation unterscheidet sich von der Hochfrequenz-Jet-Ventilation, dass sowohl neben der Inspiration auch die Exspiration aktiv ist, die Tidalvolumina kleiner sind als bei einer combined HFJV (meist unter 150 ml), der möglich anwendbare Frequenzbereich erstreckt Es kommt zunächst einerseits zu einer Erhöhung der Permeabilität der Gefäßwand mit interstitieller Ödembildung und anderseits zu einer Permeabilitätsstörung der Alveolarwand, hervorgerufen durch Membranfragmentationen der Endothelzellen und eine Degeneration der alveolären Epithelzellen (Typ-I-Pneumozyten) mit Ablösung von der Basalmembran. keywords: acute; als; alveolar; anwendung; ards; auch; bei; dass; den; der; des; die; distress; durch; eine; et al; frequency; injury; jet; kommt; lung; mit; patients; peep; respiratory; sich; sind; syndrome; und; ventilation; von; werden; wird cache: cord-017126-7ebo3cy3.txt plain text: cord-017126-7ebo3cy3.txt item: #29 of 116 id: cord-017248-a37t31u1 author: None title: Alphabetic Listing of Diseases and Conditions date: 2010-05-17 words: 48773 flesch: 37 summary: Peptic ulcers may be associated with emphysema,* tuberculosis,* and other chronic pulmonary diseases. Procedures See under Alcoholism and alcohol intoxication. keywords: abnormalities; acute; air; alcohol; analysis; aorta; aortic; arteries; artery; atresia; autopsy; blood; body; bone; brain; cases; cause; cell; cerebral; changes; chapter; chronic; column; concentrations; conditions; congenital; coronary; death; defect; deficiency; diagnosis; disease; dissection; embolism; evidence; examination; findings; formalin; gas; hand; heart; histologic; histologic study; infection; lesions; liver; lung; manifestations; material; neck; note; organs; patients; photograph; pneumonia; poisoning; preparation; prepare; present; procedures; pulmonary; record; removal; renal; report; request; right; roentgenograms; samples; sections; skin; specimen; spinal; stain; study; syndrome; synonyms; terms; time; tissue; toxicologic; tumor; type; valve; ventricular; vessels; victim; water; weight cache: cord-017248-a37t31u1.txt plain text: cord-017248-a37t31u1.txt item: #30 of 116 id: cord-017302-xez0zso3 author: Stephens, R. Scott title: ICU Complications of Hematopoietic Stem Cell Transplant, Including Graft vs Host Disease date: 2019-07-24 words: 5227 flesch: 28 summary: National Institute of Allergy and Infectious Diseases Mycoses Study Group Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia Neutropenic enterocolitis: new insights into a deadly entity The prognostic impact of abdominal surgery in cancer patients with neutropenic enterocolitis: a systematic review and meta-analysis, on behalf the Groupe de Recherche en Reanimation Respiratoire du patient d'Onco-Hematologie (GRRR-OH) Acute respiratory distress syndrome in patients with malignancies Acute respiratory distress syndrome during neutropenia recovery Pulmonary complications of bone marrow transplantation Outcomes of stem cell transplant patients with acute respiratory failure requiring mechanical ventilation in the United States Epidemiology of acute respiratory distress syndrome following hematopoietic stem cell transplantation Pulmonary infections complicating hematological disorders Febrile neutropenia: significance of elaborated screening for respiratory viruses, and the comparison of different sampling methods, in neutropenic patients with hematological malignancies Viral pneumonia in patients with hematologic malignancy or hematopoietic stem cell transplantation Mortality rates of human metapneumovirus and respiratory syncytial virus lower respiratory tract infections in hematopoietic cell transplantation recipients BCSH/BSBMT/UK clinical virology network guideline: diagnosis and management of common respiratory viral infections in patients undergoing treatment for haematological malignancies or stem cell transplantation Management of RSV infections in adult recipients of hematopoietic stem cell transplantation Management of respiratory viral infections in hematopoietic cell transplant recipients and patients with hematologic malignancies Fungal pneumonia in patients with hematologic malignancy and hematopoietic stem cell transplantation Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome Neuromuscular blockers in early acute respiratory distress syndrome Prone positioning in severe acute respiratory distress syndrome Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure The Intensive Care Medicine research agenda on critically ill oncology and hematology patients Failure of noninvasive ventilation for de novo acute hypoxemic respiratory failure: role of tidal volume Noninvasive ventilation during acute respiratory distress syndrome in patients with cancer: trends in use and outcome Effect of noninvasive ventilation vs oxygen therapy on mortality among immunocompromised patients with acute respiratory failure: a randomized clinical trial Acute respiratory failure in patients with hematological malignancies: outcomes according to initial ventilation strategy. Refinement of transplant techniques over the last 2 decades has dramatically decreased transplant-related mortality, but approximately 15% of HSCT patients require critical care keywords: acute; allogeneic; cell; failure; gvhd; hematopoietic; hsct; mortality; patients; stem; syndrome; transplant; transplantation cache: cord-017302-xez0zso3.txt plain text: cord-017302-xez0zso3.txt item: #31 of 116 id: cord-017322-82nfkms8 author: Kumar, Anupam title: Respiratory Failure in a Patient with Idiopathic Pulmonary Fibrosis date: 2019-07-24 words: 3651 flesch: 36 summary: A 2-center cohort study Effects of nasal high flow on ventilation in volunteers, COPD and idiopathic pulmonary fibrosis patients High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure Respiratory management of acute exacerbation of interstitial pneumonia using high-flow nasal cannula oxygen therapy: a single center cohort study Ventilator settings and outcome of respiratory failure in chronic interstitial lung disease Anticoagulant therapy for idiopathic pulmonary fibrosis A placebo-controlled randomized trial of warfarin in idiopathic pulmonary fibrosis Exacerbations of idiopathic pulmonary fibrosis treated with corticosteroids and cyclophosphamide pulses Efficacy of corticosteroid and intravenous cyclophosphamide in acute exacerbation of idiopathic pulmonary fibrosis: a propensity score-matched analysis Study protocol: exploring the efficacy of cyclophosphamide added to corticosteroids for treating acute exacerbation of idiopathic pulmonary fibrosis; a randomized double-blind, placebo-controlled, multi-center phase III trial (EXAFIP) Cyclosporin A followed by the treatment of acute exacerbation of idiopathic pulmonary fibrosis with corticosteroid Cyclosporin A in the treatment of acute exacerbation of idiopathic pulmonary fibrosis Effect of cyclosporine A on mortality after acute exacerbation of idiopathic pulmonary fibrosis Autoantibody-targeted treatments for acute exacerbations of idiopathic pulmonary fibrosis Recombinant human soluble thrombomodulin treatment for acute exacerbation of idiopathic pulmonary fibrosis: a retrospective study Recombinant thrombomodulin for acute exacerbation in idiopathic interstitial pneumonias Extracorporeal membrane oxygenation as a bridge to pulmonary transplantation Outcome of patients with interstitial lung disease treated with extracorporeal membrane oxygenation for acute respiratory failure A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis Pirfenidone in idiopathic pulmonary fibrosis Therapeutic effect of nintedanib on acute exacerbation of interstitial lung diseases Early studies suggested use of pirfenidone lowered the rate of acute exacerbation of idiopathic pulmonary fibrosis [5] , though this was not seen on subsequent studies [43] . keywords: acute; exacerbation; fibrosis; ipf; lung; patients cache: cord-017322-82nfkms8.txt plain text: cord-017322-82nfkms8.txt item: #32 of 116 id: cord-017374-clctlm5l author: Diamantaki, Eleni title: Acute Respiratory Failure Before ICU Admission: A Practical Approach date: 2017-06-28 words: 4306 flesch: 26 summary: The prognosis of acute respiratory failure in critically ill cancer patients Prognostic factors in critically ill cancer patients admitted to the intensive care unit Diagnostic strategy in cancer patients with acute respiratory failure Diagnostic strategy for hematology and oncology patients with acute respiratory failure: randomized controlled trial Diagnostic bronchoscopy in hematology and oncology patients with acute respiratory failure: prospective multicenter data CT signs and patterns of lung disease Role of HRCT in detection and characterization of pulmonary abnormalities in patients with febrile neutropenia Relevance of lung ultrasound in the diagnosis of acute respiratory failure: the BLUE protocol Suppressed neutrophil function as a risk factor for severe infection after cytotoxic chemotherapy in patients with acute nonlymphocytic leukemia Lung infections after cancer chemotherapy Respiratory tract infections in the immunocompromised Utility of fiberoptic bronchoscopy in neutropenic patients admitted to the intensive care unit with pulmonary infiltrates The clinical spectrum of pulmonary aspergillosis Pulmonary aspergillosis Consensus guidelines for diagnosis, prophylaxis and management of Pneumocystis jirovecii pneumonia in patients with haematological and solid malignancies Evaluation of PCR in bronchoalveolar lavage fluid for diagnosis of Pneumocystis jirovecii pneumonia: a bivariate meta-analysis and systematic review PCR diagnosis of Pneumocystis pneumonia: a bivariate meta-analysis Cytomegalovirus diseases after hematopoietic stem cell transplantation: a mini-review Diagnosis and treatment approaches to CMV infections in adult patients Acute respiratory distress syndrome: the Berlin definition Acute respiratory distress syndrome in patients with malignancies The Acute Respiratory Distress Syndrome Network. key: cord-017374-clctlm5l authors: Diamantaki, Eleni; Proklou, Athanasia; Pediaditis, Emmanouil; Amargianitakis, Vasilis; Kondili, Eumorfia title: Acute Respiratory Failure Before ICU Admission: A Practical Approach date: 2017-06-28 journal: Mechanical Ventilation in Critically Ill Cancer Patients DOI: 10.1007/978-3-319-49256-8_10 sha: doc_id: 17374 cord_uid: clctlm5l Acute respiratory failure (ARF) is a common and life-threatening event in cancer patients. keywords: acute; arf; cancer; cause; diagnosis; lung; patients; pneumonia; pulmonary cache: cord-017374-clctlm5l.txt plain text: cord-017374-clctlm5l.txt item: #33 of 116 id: cord-017603-wq4cgqs2 author: Shanmugam, Naresh title: Acute Liver Failure in Children date: 2018-10-16 words: 4433 flesch: 37 summary: Pediatr Blood Cancer Leukaemia presenting with fulminant hepatic failure in a child Autoimmune paediatric liver disease Pattern of diagnostic evaluation for the causes of pediatric acute liver failure: an opportunity for quality improvement Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States Early indicators of prognosis in fulminant hepatic failure AASLD position paper: the management of acute liver failure N-acetylcysteine on its way to a broader application in patients with acute liver failure Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: a placebo-controlled clinical trial Acute liver failure in children High-dose immunoglobulin during pregnancy for recurrent neonatal haemochromatosis Clinical human hepatocyte transplantation: current status and challenges Auxiliary liver transplantation for acute liver failure in children Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure Cell therapy for liver disease: from liver transplantation to cell factory Following infection with hepatitis A virus, the risk of developing liver failure is 0.1-0.4%, and this further increases with underlying chronic liver disease. keywords: acetaminophen; acute; alf; blood; children; disease; drug; failure; hepatitis; liver; paediatric; transplantation cache: cord-017603-wq4cgqs2.txt plain text: cord-017603-wq4cgqs2.txt item: #34 of 116 id: cord-017799-2nvrakbs author: Patel, Zara M. title: Acute Bacterial Rhinosinusitis date: 2018-05-04 words: 4393 flesch: 38 summary: A summary for otorhinolaryngologists Sinusitis of the maxillary antrum Nosocomial sinusitis in patients in the medical intensive care unit: a prospective epidemiological study Nosocomial sinusitis Rhinovirus infections in an industrial population Characteristics of illness and antibody response Adult acute rhinosinusitis A practical guide for the diagnosis and treatment of acute sinusitis The pathogenesis of orbital complications in acute sinusitis Endoscopically directed middle meatal cultures versus maxillary sinus taps in acute bacterial maxillary rhinosinusitis: a meta-analysis A 51-year-old woman with acute onset of facial pressure, rhinorrhea, and tooth pain: review of acute rhinosinusitis Clinical practice guideline for the diagnosis and management of acute bacterial sinusitis in children, aged 1 to 18 years Antibiotics for clinically diagnosed acute rhinosinusitis in adults Predicting prognosis and effect of antibiotic treatment in rhinosinusitis Effect of amoxicillin-clavulinate in clinically diagnosed acute rhinosinusitis. Most patients suffering with sinus symptoms will have a viral etiology of their inflammation [8] . keywords: abrs; acute; adults; antibiotics; days; nasal; patients; rhinosinusitis; symptoms cache: cord-017799-2nvrakbs.txt plain text: cord-017799-2nvrakbs.txt item: #35 of 116 id: cord-017856-4fccnygg author: Roden, Anja C. title: Pathology of Lung Rejection: Cellular and Humoral Mediated date: 2018-04-24 words: 7788 flesch: 31 summary: For instance, the recipient alloimmune response is thought to be related to the recognition of differences to donor antigens leading to acute lung allograft rejection. Several host genetic characteristics have been studied that may modulate acute lung rejection. keywords: acute; allograft; amr; antibodies; biopsies; bronchiolitis; hla; lung; patients; rejection; study; transbronchial; transplantation cache: cord-017856-4fccnygg.txt plain text: cord-017856-4fccnygg.txt item: #36 of 116 id: cord-017983-ehxpdavo author: Lee, Joyce S. title: Acute Exacerbation of Idiopathic Pulmonary Fibrosis date: 2013-09-13 words: 4066 flesch: 33 summary: An autopsy study Acute exacerbation (acute lung injury of unknown cause) in UIP and other forms of fi brotic interstitial pneumonias CT fi ndings during phase of accelerated deterioration in patients with idiopathic pulmonary fi brosis Pirfenidone in patients with idiopathic pulmonary fi brosis (CAPACITY): two randomised trials BUILD-3: a randomized, controlled trial of bosentan in idiopathic pulmonary fi brosis Incidence, prevalence, and clinical course of idiopathic pulmonary fi brosis: a populationbased study Anticoagulant therapy for idiopathic pulmonary fi brosis Double-blind, placebocontrolled trial of pirfenidone in patients with idiopathic pulmonary fi brosis Effi cacy of a tyrosine kinase inhibitor in idiopathic pulmonary fi brosis A Placebocontrolled randomized trial of warfarin in idiopathic pulmonary fi brosis An Offi cial ATS/ERS/ JRS/ALAT statement: idiopathic pulmonary fi brosis: evidence-based guidelines for diagnosis and management The acute respiratory distress syndrome Snyder 3rd WH. Previous or concurrent diagnosis of idiopathic pulmonary fi brosis Unexplained development or worsening of dyspnea within 30 days High-resolution computed tomography with new bilateral ground-glass abnormality and/or consolidation superimposed on a background reticular or honeycomb pattern consistent with usual interstitial pneumonia keywords: acute; aex; brosis; exacerbation; fi brosis; ipf; patients; pulmonary cache: cord-017983-ehxpdavo.txt plain text: cord-017983-ehxpdavo.txt item: #37 of 116 id: cord-018430-u3k8pds6 author: Mason, Jay W. title: Myocarditis date: 2007 words: 21762 flesch: 28 summary: Evidence for a CD18-dependent mechanism Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils Interleukin-2: inception, impact, and implications Cytokines: coordinators of immune and inflammatory responses Induction of fibroblast proliferation by human mononuclear leukocyte-derived proteins Mechanisms of immune-mediated myocyte injury Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophageconditioned medium The role of the NO pathway in the control of cardiac function Contractile depression and expression of proinflammatory cytokines and iNOS in viral myocarditis The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis Suppression of cytokines and nitric oxide production, and protection against lethal endotoxemia and viral myocarditis by a new NF-kappaB inhibitor Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha Increased serum levels of circulating intercellular adhesion molecule-1 in patients with myocarditis Increased circulating cytokines in patients with myocarditis and cardiomyopathy Augmentation of pathogenesis of coxsackievirus B3 infections in mice by exogenous administration of interleukin-1 and interleukin-2 Detection of transforming growth factor-b1 in Coxsackie B3 virus-induced murine myocarditis Concepts of autoimmunity applied to idiopathic dilated cardiomyopathy Progressive interstitial collagen deposition in Coxsackievirus B3-induced murine myocarditis Myocardial remodeling in viral heart disease: Possible interactions between inflammatory mediators and MMP-TIMP system Prevention of encephalomyocarditis virus myocarditis in mice by inactivated virus vaccine Treatment of viral myocarditis with ribavirin in an animal preparation Ribavirin treatment of murine coxsackievirus B3 myocarditis with analysis of lymphocyte subsets Prevention of viral myocarditis with recombinant human leukocyte interferon alpha A/D in a murine model Modification of viral myocarditis in mice by interleukin-6 Effects of intranasal administration of recombinant murine interferon-gamma on murine acute myocarditis caused by encephalomyocarditis virus Effects of prednisolone on acute viral myocarditis in mice A nonsteroid anti-inflammatory drug exacerbates Coxsackie B3 murine myocarditis Coxsackievirus B3 murine myocarditis: deleterious effects of nonsteroidal anti-inflammatory agents Immunosuppression with high doses of cyclophosphamide reduces the severity of myocarditis but increases the mortality in murine Coxsackievirus B3 myocarditis Effect of delayed captopril therapy on left ventricular mass and myonecrosis during acute coxsackievirus murine myocarditis Impact of FK 506 on myocarditis in the enteroviral murine model Synergistic effects of tacrolimus and human interferon-alpha A/D in murine viral myocarditis Therapeutic effect of anti-tumor necrosis factor-alpha on the murine model of viral myocarditis induced by encephalomyocarditis virus Treatment of virus-induced myocardial injury with a novel immunomodulating agent, vesnarinone. Viral myocarditis is a triphasic process. keywords: abnormalities; acute; biopsy; cardiac; cardiomyopathy; cases; cell; cell myocarditis; chagas; chronic; dcm; death; diagnosis; disease; dysfunction; evidence; failure; giant; heart; heart disease; heart failure; incidence; infection; involvement; myocardial; myocarditis; myocyte; patients; phase; study; therapy; treatment; ventricular; virus cache: cord-018430-u3k8pds6.txt plain text: cord-018430-u3k8pds6.txt item: #38 of 116 id: cord-018557-iuu38yes author: Mainous, Arch G. title: Upper Respiratory Infections and Acute Bronchitis date: 2009-09-10 words: 7113 flesch: 39 summary: A meta-analysis Diagnosis and antibiotic treatment of acute otitis media: Report from International Primary Care Network Diagnosis and management of acute otitis media Trends in doctor consultations, antibiotic prescription and specialist referrals for otitis media in children Trends in otitis media treatment and relapse National trends in emergency department antibiotic prescribing in children with acute otitis media Otitis media in children: To treat or not to treat? Wait-and-see prescription for the treatment of acute otitis media: A randomized controlled trial Management of acute otitis media by primary care physicians: Historically, acute otitis media has been one of the most common pediatric conditions seen in primary care. keywords: acute; antibiotics; bronchitis; children; group; media; otitis; patients; pharyngitis; sinusitis; treatment cache: cord-018557-iuu38yes.txt plain text: cord-018557-iuu38yes.txt item: #39 of 116 id: cord-018620-3kqx8arn author: Rueda, Mario title: Hepatic Failure date: 2016-10-09 words: 13815 flesch: 42 summary: Besides parkinsonian movements and tremors, Kayser-Fleischer rings, psychiatric alterations, and renal problems, Wilson's disease will present with liver disease: cirrhosis, chronic failure without cirrhosis, and acute liver failure. Epidemiology of acute liver failure East meets west: acute liver failure in the global village The electroencephalograph in liver disease Low myo-inositol and high glutamine levels in brain are associated with neuropsychological deterioration after induced hyperammonemia Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failure Branched-chain amino acids in liver diseases An interaction between benzodiazepines and neuroactive steroids at GABA A receptors in cultured hippocampal neurons Liver function, cerebral blood flow autoregulation, and hepatic encephalopathy in fulminant hepatic failure Difficult management problems in fulminant hepatic failure Incidence and pathophysiology of pulmonary edema in fulminant hepatic failure Pulmonary vascular complications of liver disease Hepatopulmonary syndrome: role of nitric oxide and clinical aspects Hepatorenal syndrome: pathophysiology and management Hepatorenal syndrome: a dreaded complication of end-stage liver disease Coagulopathy in liver diseases Mechanisms of water and sodium retention in cirrhosis and the pathogenesis of ascites Acute liver failure Acute liver failure Risk factors and outcomes of acute kidney injury in patients with acute liver failure Diagnosis and treatment of acute renal failure in patients with cirrhosis Lactic acidosis: recognition, kinetics, and associated prognosis Lactic acidosis Too much lactate or too little liver? Intensive care management of acute liver failure Patients with acute on chronic liver failure display sepsis-like immune paralysis Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess Effects of antimicrobial prophylaxis and blood stream infections in patients with acute liver failure: a retrospective cohort study The systemic inflammatory response syndrome in acute liver failure Infection and the progression of hepatic encephalopathy in acute liver failure Jaundice in older children and adolescents Update on the treatment of the pruritus of cholestasis Acute liver failure Medical palliation of the jaundiced patient with pruritus Acute hepatitis C AASLD position paper : the management of acute liver failure : update Propofol to control intracranial pressure in fulminant hepatic failure Management of fulminant hepatic failure in the USA: results from a survey of 14 liver transplant programs The safety and value of extradural intracranial pressure monitors in fulminant hepatic failure The American experience with transplantation for acute liver failure Ammoniainduced brain edema and intracranial hypertension in rats after portacaval anastomosis Complications of intracranial pressure monitoring in fulminant hepatic failure Cerebral and cardiovascular responses to changes in head elevation in patients with intracranial hypertension Lactulose therapy in acute liver failure Efficacy of L-ornithine L-aspartate in acute liver failure: a double-blind, randomized. keywords: acetaminophen; acute; alf; ascites; bleeding; changes; cirrhosis; cld; disease; encephalopathy; failure; hepatic; hepatitis; infection; liver; liver failure; management; patients; results; serum; system; therapy; transplantation; treatment cache: cord-018620-3kqx8arn.txt plain text: cord-018620-3kqx8arn.txt item: #40 of 116 id: cord-021554-uxxrpfl0 author: Resta-Lenert, Silvia title: Diarrhea, Infectious date: 2004-06-17 words: 2487 flesch: 42 summary: A list of the major organisms involved in the etiology of acute infectious diarrheas is presented in Table II . Endoscopy has limited utility in the investigation of acute infectious diarrhea and is not cost-effective. keywords: acute; cases; children; chronic; diarrhea; patients; year cache: cord-021554-uxxrpfl0.txt plain text: cord-021554-uxxrpfl0.txt item: #41 of 116 id: cord-022281-xn0cf33a author: Tanz, Robert R. title: Sore Throat date: 2009-05-15 words: 5736 flesch: 38 summary: There have been outbreaks of group G streptococcal pharyngitis among children. Acute rheumatic fever is not a sequela to these infections, although post-streptococcal acute glomerulonephritis has been documented in rare cases after epidemic group C and group G streptococcal pharyngitis. keywords: acute; children; culture; fever; group; infection; patients; penicillin; pharyngitis; streptococcal; throat; treatment cache: cord-022281-xn0cf33a.txt plain text: cord-022281-xn0cf33a.txt item: #42 of 116 id: cord-022451-8qtjr0a9 author: Barrett, Bruce title: Productive Cough (Acute Bronchitis) date: 2009-05-15 words: 3278 flesch: 51 summary: Cochrane Database Syst Rev Erythromycin in the treatment of acute bronchitis in a community practice Antibiotic prescribing in ambulatory care settings for adults with colds, upper respiratory tract infections, and bronchitis A placebo-controlled, double-blind trial of erythromycin in adults with acute bronchitis Quantitative systematic review of randomized controlled trials comparing antibiotic with placebo for acute cough in adults Performance of a bedside C-reactive protein test in the diagnosis of community-acquired pneumonia in adults with acute cough • A Fries JF. 2. Other causes of acute cough, such as pneumonia, gastroesophageal reflux disease, and allergy, should be considered. keywords: antibiotics; bronchitis; cough; disease; evidence; jane cache: cord-022451-8qtjr0a9.txt plain text: cord-022451-8qtjr0a9.txt item: #43 of 116 id: cord-025168-be7zube4 author: Saleh, Mahshid title: Perspective of placenta derived mesenchymal stem cells in acute liver failure date: 2020-05-24 words: 6538 flesch: 33 summary: Prospective isolation of mesenchymal stem cells from multiple mammalian species using cross-reacting anti-human monoclonal antibodies Introduction to the revised American Association for the Study of Liver Diseases Position Paper on acute liver failure Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society Bone marrow-derived mesenchymal stem cells inhibits hepatocyte apoptosis after acute liver injury Acute liver failure: current trends Acute liver failure Mesenchymal stem cell transplantation for liver cell failure: a new direction and option Acute liver failure Acute liver failure Acute liver failure: an up-to-date approach Emerging strategies for the treatment of patients with acute hepatic failure Intensive care management of acute liver failure What's new in acute liver failure? Acute liver failure: redefining the syndromes Classification, etiology, and considerations of outcome in acute liver failure Mechanisms of liver damage EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure The systemic inflammatory response syndrome in acute liver failure Complications and use of intracranial pressure monitoring in patients with acute liver failure and severe encephalopathy Fulminant hepatic failure AASLD position paper: the management of acute liver failure Lactate is important in determining prognosis in acute liver failure Hepatitis E virus infection in lung transplant recipients: a case series Acute liver failure Etiologies of acute liver failure Infectious complications of acute and chronic liver disease Role of inflammation and infection in the pathogenesis of human acute liver failure: clinical implications for monitoring and therapy Herb-Induced Liver Injuries in Developing Nations: an Oval cells in hepatitis B virus-positive and hepatitis C virus-positive liver cirrhosis: histological and ultrastructural study Activation of FoxO3a/Bim axis in patients with Primary Biliary Cirrhosis Inflammasome activation and function in liver disease Sterile inflammation in the liver Immunology in the liver-from homeostasis to disease Inflammasomes in liver diseases The impact of sterile inflammation in acute liver injury Effect of blood constituents on uptake of glucose and on metabolic rate of the brain in perfusion experiments The importance of immune dysfunction in determining outcome in acute liver failure Pathogenesis of hepatic encephalopathy in acute liver failure Infection and the progression of hepatic encephalopathy in acute liver failure SIRS score reflects clinical features of non-acetaminophen-related acute liver failure with hepatic coma Predictors of bacteraemia and mortality in patients with acute liver failure The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophen) overdose Macrophage activation and polarization: nomenclature and experimental guidelines Transcriptome-based network analysis reveals a spectrum model of human macrophage activation Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9 Nonhematopoietic mesenchymal stem cells: what are they? Age-associated changes in regenerative capabilities of mesenchymal stem cell: impact on chronic wounds repair The stem-cell niche theory: lessons from flies Human placenta-derived mesenchymal stromal cells: a review from basic research to clinical applications Human bone-cell proliferation in vitro decreases with human donor age Isolation and characterization of true mesenchymal stem cells derived from human term decidua capable of multilineage differentiation into all 3 embryonic layers Comparison of human placenta-and bone marrow-derived multipotent mesenchymal stem cells DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells Aging and replicative senescence have related effects on human stem and progenitor cells Comparison of in vitro hepatogenic differentiation potential between various placenta-derived stem cells and other adult stem cells as an alternative source of functional hepatocytes Vasculogenesis Potential of Mesenchymal and Endothelial Stem Cells Isolated from Various Human Tissues. Typically, most physiological features of liver function are controlled by liver cells or hepatocytes; therefore, the loss of hepatocytes is the main cause of liver failure. keywords: acute; alf; cells; factor; failure; growth; hepatocytes; human; liver; mesenchymal; mscs; patients; placenta; stem; tissue cache: cord-025168-be7zube4.txt plain text: cord-025168-be7zube4.txt item: #44 of 116 id: cord-027858-j8kioy8e author: Lefkowitch, Jay H. title: Acute Viral Hepatitis date: 2020-06-22 words: 4127 flesch: 34 summary: There are, however, at least three reasons why pathologists sometimes receive liver biopsy samples from patients with acute hepatitis. For all these reasons, a knowledge of the pathology of acute hepatitis is essential. keywords: acute; chronic; fig; hepatitis; infection; liver; necrosis; virus cache: cord-027858-j8kioy8e.txt plain text: cord-027858-j8kioy8e.txt item: #45 of 116 id: cord-027870-cuvfy4pj author: Baselga, Eulalia title: Inflammatory and Purpuric Eruptions date: 2020-06-22 words: 18223 flesch: 39 summary: Response to dapsone A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan Kawasaki syndrome Kawasaki disease Kawasaki disease: recent advances Kawasaki disease in infants less than one year of age Clinical spectrum of Kawasaki disease in infants younger than 6 months of age Classical Kawasaki disease in a neonate Lethal vasculitis of coronary arteries in a neonate and two infants: possible neonatal variant of the MLNS/IPN complex? Myocarditis and coronary dilatation in the 1st week of life: neonatal incomplete Kawasaki disease? Kawasaki disease: what is the epidemiology telling us about the etiology? Kawasaki syndrome in the United States 1976 to 1980 Incidence survey of Kawasaki disease in 1997 and 1998 in Japan Results of the nationwide epidemiologic survey of Kawasaki disease in 1995 and 1996 in Japan Kawasaki disease in families Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young The perineal eruption of Kawasaki syndrome Psoriatic eruption in Kawasaki disease Development of psoriatic lesions during acute and convalescent phases of Kawasaki disease Guttate psoriasis following Kawasaki disease Annular pustules in Kawasaki disease: a further case indicating the association with psoriasis? Peripheral gangrene associated with Kawasaki disease Kawasaki disease characterized by erythema and induration at the Bacillus Calmette-Guérin and purifi ed protein derivate inoculation sites Skin complications of Bacillus Calmette-Guérin immunization BCG reactivation: a useful diagnostic tool even for incomplete Kawasaki disease Infl ammation at a previous inoculation site: an unusual presentation of Kawasaki disease Diagnosis and therapy of Kawasaki disease in children Kawasaki disease: more patients are being diagnosed who do not meet American Heart Association criteria Infl ammatory pulmonary nodules in Kawasaki disease Acute respiratory distress syndrome in a child with Kawasaki disease Hemophagocytic syndrome after Kawasaki disease Sensorineural hearing loss and Kawasaki disease: A prospective study Pathogenesis and treatment of Kawasaki's disease Kawasaki disease: infection, immunity and genetics Kawasaki disease: what is the epidemiology telling us about the etiology? Development of coronary artery lesions in Kawasaki disease patients in relation to plasma interferon-gamma and interleukin-4 levels in the acute phase Circulating soluble CD23 levels in Kawasaki disease with coronary artery lesions High levels of circulating interleukin-4 and interleukin-10 in Kawasaki disease Immunopathology and cytokine detection in the skin lesions of patients with Kawasaki disease Circulating soluble L-selectin levels in Kawasaki disease with coronary artery lesions Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease Kawasaki disease in siblings Familial occurrence of Kawasaki syndrome in North America Clinical features of patients with Kawasaki disease whose parents had the same disease Serum cholesterol levels during and after Kawasaki disease Altered lipid profi le after Kawasaki syndrome Diagnosing Kawasaki syndrome: the need for a new clinical tool Diagnosis, treatment and outcome of Kawasaki disease in an Australian tertiary setting: a review of three years experience National survey of coronary artery bypass grafting for coronary stenosis caused by Kawasaki disease in Japan Mortality among persons with a history of Kawasaki disease in Japan: can paediatricians safely discontinue follow-up of children with a history of the disease but without cardiac sequelae? Mortality among persons with a history of Kawasaki disease in Japan: the fi fth look Longterm outcomes in patients with giant aneurysms secondary to Kawasaki disease Long-term consequences of Kawasaki disease. Urticaria in infants is often misdiagnosed as erythema multiforme, acute hemorrhagic edema, annular erythema of infancy, or Kawasaki disease. keywords: acute; anti; cases; children; ciency; clinical; congenital; cutaneous; defi; disease; eruption; erythema; erythropoietic; fig; heart; infants; infl; kawasaki; kawasaki disease; lesions; lupus; neonatal; nle; onset; patients; porphyria; protein; purpura; skin; sweet; syndrome; treatment; urticaria cache: cord-027870-cuvfy4pj.txt plain text: cord-027870-cuvfy4pj.txt item: #46 of 116 id: cord-028363-7pmro8bu author: Tung-Chen, Yale title: Acute pericarditis due to COVID-19 infection: An underdiagnosed disease? date: 2020-07-10 words: 1429 flesch: 42 summary: We want to share our findings, given the urgent need for different diagnostic and therapeutic strategies in order to better manage COVID-19 patients, and diminish the SARS-CoV-2 complications. On the other hand, in a recently published retrospective series of cases, a frequent elevation of d-dimer has been observed, which has been related to acute pulmonary thrombosis, which has dramatically worsened the prognosis in this subgroup of patients. keywords: acute; coronavirus; patients; pericarditis; sars cache: cord-028363-7pmro8bu.txt plain text: cord-028363-7pmro8bu.txt item: #47 of 116 id: cord-029332-yn603pvb author: None title: Full Issue PDF date: 2020-07-15 words: 11336 flesch: 34 summary: To recognize cardiovascular complications among COVID-19 patients. We are also learning that acute kidney injury is quite prevalent and highly associated with mortality in COVID-19 patients (6). keywords: acute; cardiac; cardiovascular; care; case; china; coronavirus; covid-19; diagnosis; disease; dysfunction; failure; figure; heart; history; infection; mortality; myocarditis; pandemic; patients; pneumonia; risk; sars; syndrome cache: cord-029332-yn603pvb.txt plain text: cord-029332-yn603pvb.txt item: #48 of 116 id: cord-030369-4dn02a35 author: Peng, Liang title: Clinical Manifestations and Laboratory Tests of AECHB and Severe Hepatitis (Liver Failure) date: 2019-05-21 words: 35873 flesch: 36 summary: Of the possible complications occurring in liver failure patients, bleeding is the most common and severe. Concomitant infection in liver failure patients has the following characteristics: (1) a high incidence; (2) infection may occur at different sites either simultaneously or sequentially, and abdominal and biliary tract infection is the most common. keywords: aclf; acute; acute hepatitis; alf; bilirubin; blood; cause; changes; chronic; chronic hepatitis; cirrhosis; clinical; diagnosis; encephalopathy; factors; failure patients; gene; hbv; hbv infection; hepatic; hepatitis; hepatitis patients; immune; infection; liver cells; liver cirrhosis; liver damage; liver disease; liver failure; liver function; liver injury; liver transplantation; mutation; necrosis; patients; prognosis; protein; serum; severity; stage; studies; study; therapy; treatment; type; type hepatitis; type patients; virus cache: cord-030369-4dn02a35.txt plain text: cord-030369-4dn02a35.txt item: #49 of 116 id: cord-032382-5tp9i9vh author: Hackert, Volker H. title: Signs and symptoms do not predict, but may help rule out acute Q fever in favour of other respiratory tract infections, and reduce antibiotics overuse in primary care date: 2020-09-21 words: 5646 flesch: 39 summary: During the Dutch epidemic of Q fever, general practitioners (GP's) with experience in treating Q fever patients tended to start empiric antibiotic therapy ahead of laboratory confirmation, which had a median delay of 20 days from onset of illness in 2009 key: cord-032382-5tp9i9vh authors: Hackert, Volker H.; Dukers-Muijrers, Nicole H. T. M.; Hoebe, Christian J. P. A. title: Signs and symptoms do not predict, but may help rule out acute Q fever in favour of other respiratory tract infections, and reduce antibiotics overuse in primary care date: 2020-09-21 journal: BMC Infect Dis DOI: 10.1186/s12879-020-05400-0 sha: doc_id: 32382 cord_uid: 5tp9i9vh BACKGROUND: From early 2009, the Dutch region of South Limburg experienced a massive outbreak of Q fever, overlapping with the influenza A(H1N1)pdm09 pandemic during the second half of the year and affecting approximately 2.9% of a 300,000 population. keywords: acute; disease; fever; patients; q fever; signs; study; symptoms; wave cache: cord-032382-5tp9i9vh.txt plain text: cord-032382-5tp9i9vh.txt item: #50 of 116 id: cord-253502-v2hh3w3r author: Leung, C.W. title: Clinical picture, diagnosis, treatment and outcome of severe acute respiratory syndrome (SARS) in children date: 2004-11-05 words: 8632 flesch: 40 summary: Important questions to ask in the 'peace time' include: (1) history of recent travel to pre-viously SARS-affected areas or areas with an increased likelihood of animal to human transmission of SARS-CoV infection; (2) close contact with a suspected SARS patient; (3) history of recent hospitalisation or contact with a healthcare facility; (4) individuals who are either healthcare workers or laboratory workers with potential exposure to SARS patients or live SARS-CoV; and (5) link to a cluster of cases of unexplained respiratory illness in the community. Sputum specimens appear to have a higher diagnostic yield but productive cough is uncommon in SARS patients in the early phase of illness and sputum is difficult to obtain in children. keywords: acute; adults; children; clinical; coronavirus; cov; diagnosis; disease; illness; infection; patients; pcr; sars; severe; syndrome; treatment cache: cord-253502-v2hh3w3r.txt plain text: cord-253502-v2hh3w3r.txt item: #51 of 116 id: cord-257460-e6anaxck author: Mostov, Perry D. title: Treating the Immunocompetent Patient Who Presents with an Upper Respiratory Infection: Pharyngitis, Sinusitis, and Bronchitis date: 2007-05-03 words: 7115 flesch: 34 summary: Characteristics of illness and antibody response Use of symptoms, signs, and blood tests to diagnose acute sinus infections in primary care: comparison with computed tomography Clinical evaluation for sinusitis. Making the diagnosis by history and physical examination Predicting acute maxillary sinusitis in a general practice population Analysis of symptoms and clinical signs in the maxillary sinus empyema Randomised, double blind, placebo controlled trial of penicillin V and amoxicillin in treatment of acute sinus infections in adults Antibiotic treatment of patients with mucosal thickening in the paranasal sinuses, and validation of cut-off points in sinus CT Incidental paranasal sinus abnormalities on CT of children: clinical correlation The role of computed tomography and magnetic resonance imaging in patients with sinusitis with complications Does amoxicillin improve outcomes in patients with purulent rhinorrhea? keywords: acute; adults; antibiotics; bronchitis; diagnosis; patients; sinusitis; symptoms; therapy; throat; treatment; use cache: cord-257460-e6anaxck.txt plain text: cord-257460-e6anaxck.txt item: #52 of 116 id: cord-258087-93yfs7ve author: Flores, Carlos title: A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury date: 2008-10-25 words: 4740 flesch: 28 summary: Positive genetic association studies with acute lung injury/acute respiratory distress syndrome susceptibility and/or outcome (by year of publication) Percentage of studies scored as adequate for 14 criteria (x-axis) used for the quality assessment of genetic association studies supporting susceptibility and/or outcome in acute lung injury Percentage of studies scored as adequate for 14 criteria (x-axis) used for the quality assessment of genetic association studies supporting susceptibility and/or outcome in acute lung injury. key: cord-258087-93yfs7ve authors: Flores, Carlos; del Mar Pino-Yanes, Maria; Villar, Jesús title: A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury date: 2008-10-25 journal: Crit Care DOI: 10.1186/cc7098 sha: doc_id: 258087 cord_uid: 93yfs7ve INTRODUCTION: keywords: acute; ali; ards; association; genetic; injury; lung; outcome; studies; susceptibility cache: cord-258087-93yfs7ve.txt plain text: cord-258087-93yfs7ve.txt item: #53 of 116 id: cord-258307-nsdhvc8w author: Maki, Dennis G. title: SARS Revisited: The Challenge of Controlling Emerging Infectious Diseases at the Local, Regional, Federal, and Global Levels date: 2011-10-20 words: 5024 flesch: 35 summary: [20] [21] [22] Because SARS is such a unique human viral infection and induces such an unusually severe systemic inflammatory response, 18, 19 it will be important to closely follow survivors of severe SARS for considerably longer to be certain that latently expressed progressive pulmonary fibrosis does not occur. Whereas uncontrolled studies of treated cohorts in Asia have suggested that using moderate doses of corticosteroids, 1 to 2 mg/kg of a prednisone-equivalent daily, at the first evidence of severe SARS, specifically hypoxemia, may improve survival, 59,61,62 corticosteroid therapy for SARS has had serious adverse effects, 63 and a single randomized trial of preemptive pulse corticosteroid therapy did not show benefit. keywords: avian; control; cov; health; human; influenza; outbreak; patients; sars; spread; syndrome; virus cache: cord-258307-nsdhvc8w.txt plain text: cord-258307-nsdhvc8w.txt item: #54 of 116 id: cord-258967-8wb3m3ux author: Boujaoude, Ziad C. title: Clinical Approach to Acute Cough date: 2009-08-22 words: 3244 flesch: 44 summary: Paradoxically, despite its prevalence and health and economic effects, acute cough has received relatively little attention in the medical literature compared with chronic cough. Antibiotics are not indicated for most cases of acute cough. keywords: acute; airway; bronchitis; chronic; cold; cough; treatment cache: cord-258967-8wb3m3ux.txt plain text: cord-258967-8wb3m3ux.txt item: #55 of 116 id: cord-259945-nmjwzk4e author: Bent, Stephen title: Antibiotics in acute bronchitis: a meta-analysis date: 1999-07-07 words: 3729 flesch: 36 summary: Note Added in Proof: After this paper was submitted, a meta-analysis on a similar topic was published: Smucny JJ, Becker LA, Glazier RH, McIsaac W. Are antibiotics effective treatment for acute bronchitis? Antibiotic use for acute bronchitis constitutes a substantial portion of all antibiotic use in the United States, accounting for 9% of all prescriptions written for children (26) . keywords: acute; antibiotics; bronchitis; effect; patients; use cache: cord-259945-nmjwzk4e.txt plain text: cord-259945-nmjwzk4e.txt item: #56 of 116 id: cord-260225-bc1hr0fr author: Sirpilla, Olivia title: SARS-CoV-2-Encoded Proteome and Human Genetics: From Interaction-Based to Ribosomal Biology Impact on Disease and Risk Processes date: 2020-07-20 words: 8938 flesch: 32 summary: Superfamily 1 Helicase Has RNA and DNA Duplex-Unwinding Activities with 5′-to-3′ Polarity Structure-Function Analysis of Severe Acute Respiratory Syndrome Coronavirus RNA Cap Guanine-N7-Methyltransferase Functional Screen Reveals SARS Coronavirus Nonstructural Protein Nsp14 as a Novel Cap N7 Methyltransferase Characterization of the Guanine-N7 Methyltransferase Activity of Coronavirus Nsp14 on Nucleotide GTP The Cellular RNA Helicase DDX1 Interacts with Coronavirus Nonstructural Protein 14 and Enhances Viral Replication Crystal Structure and Mechanistic Determinants of SARS Coronavirus Nonstructural Protein 15 Define an Endoribonuclease Family Crystal Structure of a Monomeric Form of Severe Acute Respiratory Syndrome Coronavirus Endonuclease Nsp15 Suggests a Role for Hexamerization as an Allosteric Switch Structural and Biochemical Characterization of Endoribonuclease Nsp15 Encoded by Middle East Respiratory Syndrome Coronavirus Binding of the Methyl Donor S-Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2′-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10 Coronavirus Nonstructural Protein 16 Is Group 2 Bat Coronaviruses A Two-Pronged Strategy to Suppress Host Protein Synthesis by SARS Coronavirus Nsp1 Protein Severe Acute Respiratory Syndrome Coronavirus Protein Nsp1 Is a Novel Eukaryotic Translation Inhibitor That Represses Multiple Steps of Translation Initiation Severe Acute Respiratory Syndrome Coronavirus Evades Antiviral Signaling: Role of Nsp1 and Rational Design of an Attenuated Strain Unique SARS-CoV Protein Nsp1: Bioinformatics, Biochemistry and Potential Effects on Virulence Coronavirus Nonstructural Protein 1: Common and Distinct Functions in the Regulation of Host and Viral Gene Expression Protein Structure and Sequence Reanalysis of 2019-NCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1 keywords: blast; cells; coronavirus; cov-2; decay; figure; human; immune; information; interaction; mrna; nonsense; nucleocapsid; protein; replication; respiratory; rna; sars; sequences; structure; syndrome cache: cord-260225-bc1hr0fr.txt plain text: cord-260225-bc1hr0fr.txt item: #57 of 116 id: cord-260238-2p209g2p author: Peiris, J S M title: Severe acute respiratory syndrome date: 2004-11-30 words: 6299 flesch: 30 summary: In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells HIV protease inhibitor nelfinavir inhibits replication of SARSassociated coronavirus Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs Interferon-β 1a and SARS coronavirus replication Severe acute respiratory syndrome-related coronavirus is inhibited by interferon-α The antiviral effect of interferon-β against SARS coronavirus is not mediated by MxA protein Old drugs as lead compounds for a new disease? HLA-B*4601 has been associated with severe SARS disease in Taiwan 94 but not Hong Kong 95 . keywords: associated; cells; coronavirus; cov; disease; health; human; individuals; infection; outbreak; protein; sars; spike; syndrome; transmission cache: cord-260238-2p209g2p.txt plain text: cord-260238-2p209g2p.txt item: #58 of 116 id: cord-261856-i1e0uj0s author: Heffner, John E title: Chronic obstructive pulmonary disease in geriatric critical care date: 2005-03-04 words: 4818 flesch: 32 summary: A model analysis in the netherlands The evidence base for management of acute exacerbations of COPD: clinical practice guideline, part 1 Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease Toward a consensus definition for COPD exacerbations Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations Airway eosinophilia in chronic bronchitis during exacerbations Airway eosinophilia and expression of interleukin-5 protein in asthma and in exacerbations of chronic bronchitis Exacerbations of Bronchitis: bronchial eosinophilia and gene expression for interleukin-4, interleukin-5, and eosinophil chemoattractants Relationship of sputum color to nature and outpatient management of acute exacerbations of COPD Air pollution and daily admissions for chronic obstructive pulmonary disease in 6 European cities: results from the APHEA project Effect of temperature on lung function and symptoms in chronic obstructive pulmonary disease Randomized, doubleblind study of ciprofloxacin and cefuroxime axetil for treatment of acute bacterial exacerbations of chronic bronchitis. key: cord-261856-i1e0uj0s authors: Heffner, John E; Highland, Kristin B title: Chronic obstructive pulmonary disease in geriatric critical care date: 2005-03-04 journal: Crit Care Clin DOI: 10.1016/s0749-0704(03)00054-x sha: doc_id: 261856 cord_uid: i1e0uj0s COPD is a progressive disorder that is punctuated in its later stages with acute exacerbations that present a risk for respiratory failure. keywords: airway; care; chronic; copd; disease; exacerbations; failure; life; lung; patients; ventilation cache: cord-261856-i1e0uj0s.txt plain text: cord-261856-i1e0uj0s.txt item: #59 of 116 id: cord-262523-hxoyfh6o author: Kaur, Gagandeep title: Resolution of Acute Disseminated Encephalomyelitis Following Termination of Pregnancy date: 2014-02-28 words: 1982 flesch: 37 summary: The follow-up of acute disseminated encephalomyelitis in a comatose pregnant woman An autopsy case of acute multiple sclerosis (Marburg's type) during pregnancy Multiple sclerosis and pregnancy Offspring number, pregnancy, and risk of a first clinical demyelinating event: the autoimmune study Impact of pregnancy on conversion to clinically isolated syndrome in a radiologically isolated syndrome cohort Pregnancy and pregnancyassociated hormones alter immune responses and disease pathogenesis Alternatively, a direct immune-mediated response to the fetus may have triggered the ADEM; this is supported by the beginning of recovery after pregnancy termination in our vignette. keywords: acute; adem; case; encephalomyelitis; pregnancy; treatment cache: cord-262523-hxoyfh6o.txt plain text: cord-262523-hxoyfh6o.txt item: #60 of 116 id: cord-262843-i0cy7467 author: Suzumoto, Masaki title: A scoring system for management of acute pharyngo-tonsillitis in adults date: 2008-09-05 words: 3342 flesch: 42 summary: Numbers of total white blood cells and levels of C-reactive protein showed a significant positive correlation with clinical scores (p < 0.001) and were also higher in cases with S. pyogenes. Correlation between clinical scores and numbers of WBC or levels of CRP were assessed Pearson regression analysis. keywords: acute; cases; patients; pharyngo; study; tonsillitis cache: cord-262843-i0cy7467.txt plain text: cord-262843-i0cy7467.txt item: #61 of 116 id: cord-263285-89zqgqx1 author: Sethi, Sanjum S. title: Right Ventricular Clot in Transit in COVID-19: Implications for the Pulmonary Embolism Response Team date: 2020-05-29 words: 1856 flesch: 36 summary: After presenting a case of right ventricular thrombus in a COVID-19 patient, we discuss the unique challenges in the workup and treatment of COVID-19 patients highlighting our COVID-19 modified pulmonary embolism response team (PERT) algorithm. Given this increased potential for hypercoagulable events, yet being mindful of exposure risks and practical considerations in caring for COVID-19 patients, we present the first report of a COVID-19 patient with clot in transit, along with an algorithm for diagnosing and treating venous thromboembolism in COVID-19 patients. keywords: acute; anticoagulation; covid-19; embolism; illness; patient cache: cord-263285-89zqgqx1.txt plain text: cord-263285-89zqgqx1.txt item: #62 of 116 id: cord-266303-6igk5jmn author: Yang, Xiaopeng title: Acute kidney injury and renal replacement therapy in COVID-19 patients: a systematic review and meta-analysis date: 2020-11-03 words: 3334 flesch: 42 summary: key: cord-266303-6igk5jmn authors: Yang, Xiaopeng; Tian, Shasha; Guo, Hui title: Acute kidney injury and renal replacement therapy in COVID-19 patients: a systematic review and meta-analysis date: 2020-11-03 journal: Int Immunopharmacol DOI: 10.1016/j.intimp.2020.107159 sha: doc_id: 266303 cord_uid: 6igk5jmn Purpose Reported rates of acute kidney injury (AKI) have varied significantly among studies of coronavirus disease 2019 (COVID-19) published to date. The present meta-analysis was conducted to gain clarity regarding AKI incidence and renal replacement therapy (RRT) use in COVID-19 patients. keywords: acute; aki; coronavirus; covid-19; kidney; patients; studies; study cache: cord-266303-6igk5jmn.txt plain text: cord-266303-6igk5jmn.txt item: #63 of 116 id: cord-267436-mivxm8oh author: Groneberg, David A title: Treatment and vaccines for severe acute respiratory syndrome date: 2005-03-10 words: 5918 flesch: 36 summary: The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen A cluster of cases of severe acute respiratory syndrome in Hong Kong A major outbreak of severe acute respiratory syndrome in Hong Kong Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR China Severe acute respiratory syndromerelated coronavirus is inhibited by interferon-alpha Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus Severe acute respiratory syndrome-associated coronavirus in lung tissue Common adverse events associated with the use of ribavirin for severe acute respiratory syndrome in Canada Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Novel peptide inhibitors of angiotensin-converting enzyme 2 Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors Cloaked similarity between HIV-1 and SARS-CoV suggests an anti-SARS strategy Inhibiting severe acute respiratory syndrome-associated coronavirus by small interfering RNA Modulation of HIV-1 replication by RNA interference Interference of hepatitis C virus RNA replication by short interfering RNAs Short interfering RNA-directed inhibition of hepatitis B virus replication Silencing SARS-CoV spike protein expression in cultured cells by RNA interference Inhibition of SARS-associated coronavirus infection and replication by RNA interference Effect of glycyrrhizin, an active component of licorice roots, on HIV replication in cultures of peripheral blood mononuclear cells from HIV-seropositive patients Long-term treatment of chronic hepatitis C with glycyrrhizin [stronger neo-minophagen C (SNMC)] for preventing liver cirrhosis and hepatocellular carcinoma Lamivudine and glycyrrhizin for treatment of chemotherapy-induced hepatitis B virus (HBV) hepatitis in a chronic HBV carrier with non-Hodgkin lymphoma Induction of inducible nitric oxide synthase and proinflammatory cytokines expression by o,pЈ-DDT in macrophages Inhibition of SARS-CoV infection in vitro by S-nitroso-Nacetylpenicillamine, a nitric oxide donor compound Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness Role of nitric oxide in chronic allergen-induced airway cell proliferation and inflammation Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide Small molecules targeting severe acute respiratory syndrome human coronavirus Pro/con clinical debate: steroids are a key component in the treatment of SARS Lung pathology of fatal severe acute respiratory syndrome Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area Severe acute respiratory syndrome (SARS) in Singapore: clinical features of index patient and initial contacts High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome Fatal aspergillosis in a patient with SARS who was treated with corticosteroids SARS: prognosis, outcome and sequelae Avascular necrosis of bone in severe acute respiratory syndrome Role of interferons in the treatment of severe acute respiratory syndrome Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs Interferon-beta 1a and SARS coronavirus replication Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques How the SARS vaccine effort can learn from HIVspeeding towards the future, learning from the past Treatment of severe acute respiratory syndrome with convalescent plasma Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets Caution urged on SARS vaccines A review of feline infectious peritonitis virus: molecular biology, immunopathogenesis, clinical aspects, and vaccination Effects of a SARS-associated coronavirus vaccine in monkeys Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice Nucleic acid vaccines: an overview A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice Generation and characterization of DNA vaccines targeting the nucleocapsid protein of severe acute respiratory syndrome coronavirus Induction of SARS-nucleoproteinspecific immune response by use of DNA vaccine SARS-one year later Seasonality of infectious diseases and severe acute respiratory syndrome-what we don't know can hurt us Clinical trials and novel pathogens: lessons learned from SARS Preparing to prevent severe acute respiratory syndrome and other respiratory infections Collateral damage: the unforeseen effects of emergency outbreak policies Support from the Deutsche Atemwegsliga and the German Research Foundation (DFG GR2014/2-1) to DAG is gratefully acknowledged. 13, 14 Evidence suggests that SARS coronavirus originated from SARS-like viruses in animals in the southern Chinese province of Guangdong; the most frequently implicated animal is the Himalayan palm civet, an animal found in food markets and eaten as a delicacy. keywords: coronavirus; outbreak; protein; replication; ribavirin; sars; severe; spike; steroids; syndrome; treatment; vaccines cache: cord-267436-mivxm8oh.txt plain text: cord-267436-mivxm8oh.txt item: #64 of 116 id: cord-270776-oulnk1b3 author: Chau, Tai-nin title: Value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome date: 2004-08-15 words: 2776 flesch: 40 summary: Patients with more than two zones of lung involvement presented significantly later than patients with fewer zones of involvement (6 Ϯ 3 days vs. 4 Ϯ 2 days after onset of symptoms, P ϭ 0.001) Philadelphia Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study Defining prognostic factors in the elderly with community acquired pneumonia: a case controlled study of patients aged Ͼ or ϭ 75 yrs Simplified prediction rule for prognosis of patients with severe community-acquired pneumonia in ICUs Severe Acute Respiratory Syndrome: radiographic appearances and pattern of progression in 138 patients Clinical features and short-term outcomes of 144 patients with SARS in the Greater Toronto area Quantitative analysis and prognostic implication of SARS-coronavirus RNA in the plasma and serum of patients with severe acute respiratory syndrome Interobserver variability in applying a radiographic definition for ARDS Severe Acute Respiratory Syndrome (SARS) in Singapore: clinical features of index patient and initial contacts Prognostic Features of Chest Radiographs in SARS/Chau et al keywords: acute; chest; involvement; patients; sars; zones cache: cord-270776-oulnk1b3.txt plain text: cord-270776-oulnk1b3.txt item: #65 of 116 id: cord-273035-sewfb3q8 author: Kang, Xixiong title: Proteomic Fingerprints for Potential Application to Early Diagnosis of Severe Acute Respiratory Syndrome date: 2005-01-01 words: 4137 flesch: 44 summary: Among the retrospective samples, only 74 were selected from probable patients whose blood samples were collected with onset of fever within 7 days at the time of admission (acute SARS patients; Table 1 ). Serum samples were grouped into acute SARS (n = 74; <7 days after onset of fever) and non-SARS [n = 1067; fever and influenza A (n = 203), pneumonia (n = 176); lung cancer (n = 29); and healthy controls (n = 659)] cohorts. keywords: mass; non; patients; peak; samples; sars; serum; set; spectra cache: cord-273035-sewfb3q8.txt plain text: cord-273035-sewfb3q8.txt item: #66 of 116 id: cord-274802-7ioiwsd8 author: Varghese, Praveen Mathews title: Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies date: 2020-08-19 words: 19710 flesch: 31 summary: Unlike SARS, COVID-19 patients had the highest viral load near presentation, which could account for the fast-spreading nature of this epidemic. In a study involving COVID-19 patients in Hong Kong recorded high viral load on presentation with the onset of symptoms and also when the symptoms are mild (83) . keywords: activation; acute; antibodies; case; cells; china; complement; coronavirus; cov-2; covid-19; covid-19 patients; disease; dose; drug; high; human; infection; inflammation; injury; levels; novel; pathogenesis; patients; plasma; pneumonia; protein; response; sars; spike; studies; study; syndrome; system; transmission; treatment; trial; vaccine cache: cord-274802-7ioiwsd8.txt plain text: cord-274802-7ioiwsd8.txt item: #67 of 116 id: cord-275440-fl4dsu7d author: Turnidge, John title: Responsible Prescribing for Upper Respiratory Tract Infections date: 2012-10-10 words: 6474 flesch: 41 summary: A clinical scoring method to reduce unnecessary antibiotic use in patients with sore throat Pharyngitis -principles of judicious use of antimicrobial agents Acute otitis media: management and surveillance in an era of pneumococcal resistance -a report from the Drug-resistant Streptococcus pneumoniae Therapeutic Working Group Recurrent and persistent otitis media Antibiotic for acute otitis media in children (Cochrane review). Most favour the strategy of prescribing antibacterials only when certain criteria are fulfilled, delaying antibacterial prescribing for at least 24 hours. keywords: antibacterials; benefit; infection; media; otitis; patients; prescribing; throat; treatment; use cache: cord-275440-fl4dsu7d.txt plain text: cord-275440-fl4dsu7d.txt item: #68 of 116 id: cord-275700-tx4hirm4 author: Whiteside, James L title: Acute bronchitis: a review of diagnosis and evidence-based management date: 2002-06-30 words: 2954 flesch: 39 summary: A meta-analysis Antibiotics for acute bronchitis (Cochrane Review) Quantitative systematic review of randomised controlled trials comparing antibiotic with placebo for acute cough in adults Airway infection Antibiotic prescribing for patients with colds, upper respiratory tract infections, and bronchitis: a national study of hospital-based emergency departments Acute bronchitis Diagnosis of acute bronchitis in adults: a national survey of family physicians Pulmonary function test in acute bronchitis: evidence for reversible airway obstruction An association between acute bronchitis and asthma Principles of appropriate antibiotic use for treatment of uncomplicated acute bronchitis: background Factors associated with antibiotic use for acute bronchitis Antibiotics in acute bronchitis: a meta-analysis Efficacy and safety of the oral neuraminindase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial Neuraminidase inhibitors for preventing and treating influenza in healthy adults (Cochrane Review) keywords: acute; antibiotics; bronchitis; cough; patients; use cache: cord-275700-tx4hirm4.txt plain text: cord-275700-tx4hirm4.txt item: #69 of 116 id: cord-276927-rxudwp2v author: Barbas, Carmen Sílvia Valente title: Goal-Oriented Respiratory Management for Critically Ill Patients with Acute Respiratory Distress Syndrome date: 2012-08-23 words: 8003 flesch: 26 summary: Revaluation of ARDS patients on the third day of evolution (Sequential Organ Failure Assessment (SOFA), biomarkers and response to infection therapy) allows changes in the initial treatment plans and can help decrease ARDS mortality. Fibrosis can be evident histologically as early as one week after the onset of ARDS and procollagen III peptide, a precursor of collagen synthesis, can be elevated in bronchoalveolar lavage fluid of ARDS patients at the time of tracheal intubation, its increment being associated with a poor ARDS prognosis. keywords: acute; ards; distress; injury; lung; mortality; oxygenation; patients; peep; pressure; pulmonary; risk; study; syndrome; ventilation; ventilatory cache: cord-276927-rxudwp2v.txt plain text: cord-276927-rxudwp2v.txt item: #70 of 116 id: cord-278319-44bvju3g author: Gonzales, Ralph title: Principles of appropriate antibiotic use for treatment of uncomplicated acute bronchitis: Background date: 2001-06-30 words: 4806 flesch: 31 summary: Noninfectious causes of uncomplicated acute bronchitis, such as occult asthma exacerbation or toxic fume inhalation, should also be considered, although the prevalence of these conditions in adults with acute cough illness has not been well studied. When evaluating an otherwise healthy adult with uncomplicated acute cough illness, the primary diagnostic objective should be to exclude the presence of pneumonia. keywords: adults; antibiotic; bronchitis; cough; duration; illness; influenza; patients; pneumonia; treatment cache: cord-278319-44bvju3g.txt plain text: cord-278319-44bvju3g.txt item: #71 of 116 id: cord-280070-c1bkhgaz author: Azadeh, Natalya title: The Role of Infection in Interstitial Lung Diseases A Review date: 2017-10-31 words: 6531 flesch: 34 summary: Sarcoidosis Vasc Diffuse Lung Dis Sarcoidosis: in search of the cause Evidence for mycobacteria in sarcoidosis Etiology of sarcoidosis: does infection play a role? Immunolocalization of cell-wall-deficient forms of Mycobacterium tuberculosis complex in sarcoidosis and in sinus histiocytosis of lymph nodes draining carcinoma Molecular evidence for the role of mycobacteria in sarcoidosis: a meta-analysis High prevalence of Mycobacterium tuberculosis DNA in biopsies from sarcoidosis patients from Catalonia Quantitative analysis of mycobacterial and propionibacterial DNA in lymph nodes of Japanese and European patients with sarcoidosis Is there any association between sarcoidosis and infectious agents? Infectious causes need to be considered in the diagnostic evaluation of patients with suspected IIP, since the histopathologic patterns of lung injury underlying some IIPs can also be seen in pulmonary infections (Table 1) . keywords: acute; fibrosis; ild; infection; interstitial; ipf; lung; patients; pneumonia; pulmonary; role cache: cord-280070-c1bkhgaz.txt plain text: cord-280070-c1bkhgaz.txt item: #72 of 116 id: cord-283367-azzy2t1a author: Rahman, Asma title: Neurological manifestations in COVID-19: A narrative review date: 2020-09-10 words: 4452 flesch: 48 summary: 14 Awareness by clinicians of the possibility of CVD in COVID-19 patients may lead to more timely management decisions and thus a reduction in both morbidity and mortality. Reports an association between stroke and pneumonia severity in COVID-19 patients. keywords: acute; cov-2; covid-19; csf; manifestations; patients; sars; stroke cache: cord-283367-azzy2t1a.txt plain text: cord-283367-azzy2t1a.txt item: #73 of 116 id: cord-284332-p4c1fneh author: Bosma, Karen J. title: Pharmacotherapy for Prevention and Treatment of Acute Respiratory Distress Syndrome: Current and Experimental Approaches date: 2012-09-19 words: 14538 flesch: 29 summary: The use of an inflammation-modulating diet in patients with acute lung injury or acute respiratory distress syndrome: a metaanalysis of outcome data Efficacy of an expanded ventilator bundle for the reduction of ventilatorassociated pneumonia in the medical intensive care unit Continuous aspiration of subglottic secretions in the prevention of ventilatorassociated pneumonia in the postoperative period of major heart surgery Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial Thromboprophylaxis in medicalsurgical critically ill patients Stress ulcer prophylaxis in critically ill patients: resolving discordant meta-analyses Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial Effects of physical training on functional status in patients with prolonged mechanical ventilation Recent trends in acute lung injury mortality: 1996-2005 Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis Effect of prone positioning in patients with acute respiratory distress syndrome: a metaanalysis Effect of mechanical ventilation in the prone position on clinical outcomes in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis1 Hemodynamic and gas exchange response to inhaled nitric oxide and prone positioning in acute respiratory distress syndrome patients High-frequency oscillatory ventilation in adults: the Toronto experience High-frequency oscillatory ventilation for adult patients with ARDS Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial Extracorporeal membrane oxygenation for 2009 influenza A (H1N1) acute respiratory distress syndrome Ketoconazole prevents acute respiratory failure in critically ill surgical patients A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome Development, implementation, and evaluation of a ketoconazole practice guideline for ARDS prophylaxis Angiotensin-converting enzyme inhibitor captopril prevents oleic acid-induced severe acute lung injury in rats Rosiglitazone attenuates the severity of sodium taurocholate-induced acute pancreatitis and pancreatitis-associated lung injury Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: phase IIb, multicenter, randomized, placebo-controlled, clinical trial Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial The Beta-Agonist Lung Injury Trial (BALTI): a randomized placebo-controlled clinical trial Randomized, placebo-controlled trial of an aerosolized beta-2 adrenergic agonist (albuterol) for the treatment of acute lung injury Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome: Exosurf Acute Respiratory Distress Syndrome Sepsis Study Group Bovine surfactant therapy for patients with acute respiratory distress syndrome Venticute in patients with pneumonia or aspiration of gastric contents and intubation/ventilation/oxygenation impairment (BY2001/M1-007) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome The American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury Arachidonic acid remodeling in human inflammatory cells migrating to the lung in vivo Recent advances in genetic predisposition to clinical acute lung injury Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock Pharmacotherapy of acute lung injury and acute respiratory distress syndrome Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? keywords: acute; ali; alveolar; ards; day; distress; group; injury; lung; mortality; neutrophil; patients; phase; results; risk; studies; study; surfactant; syndrome; treatment; trial; ventilation cache: cord-284332-p4c1fneh.txt plain text: cord-284332-p4c1fneh.txt item: #74 of 116 id: cord-285291-pep4opiq author: Remy, Kenneth E. title: Caring for Critically Ill Adults With Coronavirus Disease 2019 in a PICU: Recommendations by Dual Trained Intensivists* date: 2020-04-29 words: 7169 flesch: 29 summary: Part 2: Treatment Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report Treatment of acute pulmonary embolism: Update on newer pharmacologic and interventional strategies guidelines for management of venous thromboembolism: Prophylaxis for hospitalized and nonhospitalized medical patients Clinical Guidelines Committee of the American College of Physicians: Venous thromboembolism prophylaxis in hospitalized patients: A clinical practice guideline from the American College of Physicians Diagnosis of gastrointestinal bleeding: A practical guide for clinicians PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group: Effect of stress ulcer prophylaxis with proton pump inhibitors vs histamine-2 receptor blockers on in-hospital mortality among ICU patients receiving invasive mechanical ventilation: The PEPTIC randomized clinical trial Hyperglycemic crises in adult patients with diabetes Hyperosmolar hyperglycemic state: A historic review of the clinical presentation, diagnosis, and treatment Acute kidney injury enhances outcome prediction ability of sequential organ failure assessment score in critically ill patients Acute renal impairment in coronavirus-associated severe acute respiratory syndrome SMART Investigators and the Pragmatic Critical Care Research Group: Balanced crystalloids versus saline in critically ill adults Delirium in the critically ill patient Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU ICU delirium -a diagnostic and therapeutic challenge in the intensive care unit Sedation and delirium in the intensive care unit Incidence and prevalence of pressure injuries in adult intensive care patients: A systematic review and meta-analysis Risk factors for pressure injury development in critically ill patients in the intensive care unit: A systematic review protocol ICU-acquired weakness and recovery from critical illness Critical illness polyneuropathy and myopathy: A major cause of muscle weakness and paralysis Critical illness myopathy and neuropathy Pressure injury risk factors in adult critical care patients: A review of the literature Effectiveness of pressure ulcer prevention strategies for adult patients in intensive care units: A systematic review Treatment of pressure ulcers: A systematic review Management of acute alcohol withdrawal syndrome in critically ill patients Approach to the complicated alcohol withdrawal patient The use of dexmedetomidine as an adjuvant to benzodiazepine-based therapy to decrease the severity of delirium in alcohol withdrawal in adult intensive care unit patients: A systematic review Proxy decision making for incompetent patients. Acute decompensated heart failure (ADHF) is one of the main causes of respiratory distress in adult patients requiring the ICU (99) . keywords: acute; adults; care; covid-19; disease; distress; failure; heart; icu; management; mortality; patients; pressure; sedation; syndrome; treatment; trial; use; ventilation cache: cord-285291-pep4opiq.txt plain text: cord-285291-pep4opiq.txt item: #75 of 116 id: cord-285557-my16g91c author: Berger, A. title: Severe acute respiratory syndrome (SARS)—paradigm of an emerging viral infection date: 2004-01-31 words: 6386 flesch: 40 summary: Koch's postulates fulfilled for SARS virus Critically ill patients with severe acute respiratory syndrome SARS genome patent: symptom or disease? Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Severe acute respiratory syndrome (SARS): breath-taking progress Electron microscopy for rapid diagnosis of infectious agents in emergent situations SARS coronavirus: a new challenge for prevention and therapy Clinical presentations and outcome of severe acute respiratory syndrome in children Hong Kong Department of Health. Hong Kong researchers reported at the WHO Global Conference on SARS in Kuala Lumpur in June 2003 that SARS patients treated with Kaletra (lopinavir with low-dose ritonavir) plus ribavirin experienced a 50% reduction in death rate. keywords: cases; coronavirus; cov; et al; health; human; organization; patients; sars; syndrome; transmission; world cache: cord-285557-my16g91c.txt plain text: cord-285557-my16g91c.txt item: #76 of 116 id: cord-286033-klkoyw1r author: None title: COVID-19 medical sequelae date: 2020-09-15 words: 560 flesch: 42 summary: Reversible acute renal failures, related to fluid and electrolyte disturbances, have been observed. Frequent in the acute phase, proteinuria, microscopic hematuria and moderate elevation of creatinine reflect renal damage. keywords: damage; fibrosis cache: cord-286033-klkoyw1r.txt plain text: cord-286033-klkoyw1r.txt item: #77 of 116 id: cord-286408-bhrrb5s7 author: None title: Medical sequelae of COVID-19 date: 2020-09-15 words: 1202 flesch: 39 summary: key: cord-286408-bhrrb5s7 authors: nan title: Medical sequelae of COVID-19 date: 2020-09-15 journal: Because of the spread of the pandemic, even a small percentage of medical sequelae represent a nationwide public health problem. keywords: covid-19; disorders; patients; phase cache: cord-286408-bhrrb5s7.txt plain text: cord-286408-bhrrb5s7.txt item: #78 of 116 id: cord-287648-nhsn4cru author: Cameli, Matteo title: Usefulness of echocardiography to detect cardiac involvement in COVID‐19 patients date: 2020-07-12 words: 3047 flesch: 21 summary: The left atrium and the right ventricle: two supporting chambers to the failing left ventricle Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging ACUTE HF score, a multiparametric prognostic tool for acute heart failure: a real-life study Prognostic Value of Right Ventricular Longitudinal Strain in Patients with COVID-19 Echocardiography to guide fluid therapy in critically ill patients: check the heart and take a quick look at the lungs Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected Serial evaluation of the SOFA score to predict outcome in critically ill patients Prognostic impact of left ventricular diastolic function in patients with septic shock Early diastolic dysfunction is associated with intensive care unit mortality in cancer patients presenting with septic shock Outcome prediction in sepsis: speckle tracking echocardiography based assessment of myocardial function Left ventricular global longitudinal strain is independently associated with mortality in septic shock patients Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP) vs low PEEP on mortality in patients with acute respiratory distress syndrome: a randomized clinical trial Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: Interim guidance. Accordingly, current reports suggest that the majority of COVID-19 patients with myocardial injury without evidence of epicardial coronary artery thrombosis, show imaging data supporting the diagnosis of acute myocarditis 21, 22 ; also, cases of fulminant myocarditis and fatal arrhythmias have been described. keywords: acute; coronavirus; covid-19; disease; echocardiography; injury; myocarditis; patients; syndrome cache: cord-287648-nhsn4cru.txt plain text: cord-287648-nhsn4cru.txt item: #79 of 116 id: cord-288229-d3s8oe53 author: Akgul, Ahmet title: ACUTE AORTIC DISSECTION SURGERY IN PATIENT WITH COVID-19 date: 2020-06-17 words: 1067 flesch: 44 summary: Acute aortic dissection is one of the most common life-threatening disease which affects aortic vessel. During aortotomy, in our case, we evaluated the aorta, which revealed pronounced thickening of the wall (as seen in inflammatory aortopathies [4] ) when compared with our experience in previous aortic dissection published [5] and/or unpublished cases. keywords: acute; aortic; covid-19; dissection cache: cord-288229-d3s8oe53.txt plain text: cord-288229-d3s8oe53.txt item: #80 of 116 id: cord-289090-7x2752j4 author: Vergison, Anne title: Microbiology of otitis media: A moving target date: 2008-12-23 words: 3447 flesch: 31 summary: It was recovered in middle ear fluid (MEF) in 12% of first AOM episodes compared with 25% of all subsequent OM episodes, and when only the first AOM episodes were considered, no peak in the incidence of H. influenzae AOM could be demonstrated in children over 1 year of age. Bacteriological and clinical observations Otitis media: a clinical and bacteriological correlation Association of clinical signs and symptoms with pneumococcal acute otitis media by serotype -implications for vaccine effect Acute otitis media: diagnosis and management in the year 2000 Complications of acute otitis media in children in southern Finland National differences in incidence of acute mastoiditis: relationship to prescribing patterns of antibiotics for acute otitis media? Acute mastoiditis in Southern Israel: a twelve year retrospective study Sustained reduction of antibiotic use and low bacterial resistance: 10-year follow-up of the Swedish Strama programme Analysis of the causes and consequences of decreased antibiotic consumption over the last 5 years in Slovenia Protective effect of antibiotics against serious complications of common respiratory tract infections: retrospective cohort study with the UK General Practice Research Database Pathogens causing recurrent and difficult-to-treat acute otitis media Evidence of bacterial metabolic activity in culture-negative otitis media with effusion Phenotypic characterization of Streptococcus pneumoniae biofilm development Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear Biofilm formation by nontypeable Haemophilus influenzae: strain variability, outer membrane antigen expression and role of pili Biofilm formation by Moraxella catarrhalis in vitro: roles of the UspA1 adhesin and the Hag hemagglutinin Haemophilus influenzae forms biofilms on airway epithelia: implications in cystic fibrosis Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media The antibiotic paradox Outpatient antibiotic use in Europe and association with resistance: a cross-national database study Streptococcus pneumoniae: epidemiology and patterns of resistance European Academies Science Advisory Council. keywords: acute; aom; children; influenzae; media; otitis; pneumoniae cache: cord-289090-7x2752j4.txt plain text: cord-289090-7x2752j4.txt item: #81 of 116 id: cord-289816-rlwoy8ms author: Tedeschi, Delio title: Acute myocardial infarction and large coronary thrombosis in a patient with COVID‐19 date: 2020-08-07 words: 1451 flesch: 30 summary: This case report highlights the clinical impact of ACS-STEMI in COVID-19 patients. This clinical case suggests that coronary thrombosis in COVID‐19 patients may be unresponsive to optimal pharmacological (GP IIb–IIIa infusion) and mechanical treatment (PCI). was transferred from another hospital to our institution. keywords: covid-19; infarction; patient; thrombosis cache: cord-289816-rlwoy8ms.txt plain text: cord-289816-rlwoy8ms.txt item: #82 of 116 id: cord-291517-ifei60ly author: Dixon, Luke title: COVID-19-related acute necrotizing encephalopathy with brain stem involvement in a patient with aplastic anemia date: 2020-05-26 words: 1847 flesch: 37 summary: Neurologic manifestations of hospitalized patients with coronavirus disease COVID-19-associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features Epstein-barr virus-associated lymphoproliferative disorder with encephalitis following anti-thymocyte globulin for aplastic anemia resolved with rituximab therapy: a case report and literature review Intact survival of refractory CMV limbic encephalitis in a patient with severe aplastic anemia after unrelated bone marrow transplantation Acute necrotizing encephalopathy of childhood: correlation of MR findings and clinical outcome Acute necrotizing encephalopathy associated with novel influenza H1N1 (pdm09) infection: MRI and correlation with brain necropsy Acute necrotizing encephalopathy of childhood: a novel form of acute encephalopathy prevalent in Japan and Taiwan Influenza-associated encephalopathy in Japan: pathogenesis and treatment Detection of influenza virus RNA by reverse transcription-PCR and proinflammatory cytokines in influenza-virus-associated encephalopathy To describe a novel case of coronavirus disease 2019 (COVID-19)-associated acute necrotizing encephalopathy (ANE) in a patient with aplastic anemia where there was early brain stem-predominant involvement. keywords: acute; brain; covid-19; encephalopathy; patient; stem cache: cord-291517-ifei60ly.txt plain text: cord-291517-ifei60ly.txt item: #83 of 116 id: cord-294062-3esrg1jw author: Tam, Clarence C. title: Association between semi-quantitative microbial load and respiratory symptoms among Thai military recruits: a prospective cohort study date: 2018-09-14 words: 4514 flesch: 33 summary: Viruses were detected in 13.8% (43/312) and bacteria in 93.3% (291/312) of non-acute samples. Hi-nonB, rhinovirus, and coronavirus 229 were detected significantly less frequently in non-acute samples collected at the start of the training period than acute samples (p-values < 0.05) ( Table 1) . keywords: acute; infection; load; non; samples; specimens; tract; value cache: cord-294062-3esrg1jw.txt plain text: cord-294062-3esrg1jw.txt item: #84 of 116 id: cord-294638-tuxwmv0v author: Alawadhi, Abdulla title: Acute Hemorrhagic Encephalitis Responding to Combined Decompressive Craniectomy, Intravenous Immunoglobulin, and Corticosteroid Therapies: Association with Novel RANBP2 Variant date: 2018-03-12 words: 2769 flesch: 38 summary: Acute hemorrhagic leukoencephalitis: a previously undefined entity Acute necrotizing hemorrhagic encephalopathy Acute hemorrhagic leukoencephalitis mimicking herpes simplex encephalitis: case report Plasmapheresis in fulminant acute disseminated encephalomyelitis Acute hemorrhagic leukoencephalitis: report of three cases and review of the literature A medical overview of encephalitis Acute hemorrhagic leukoencephalitis in a patient with sickle cell disease: a case report Pediatric acute hemorrhagic leukoencephalitis: report of a surviving patient and review Treatment leading to dramatic recovery in acute hemorrhagic leukoencephalitis Dominant encephalopathy mimicking mitochondrial disease Acute necrotizing encephalopathy progressing to brain death in a pediatric patient with novel influenza A (H1N1) infection Central nervous system complications and management in sickle cell disease Primary hemorrhagic stroke in children with sickle cell disease is associated with recent transfusion and use of corticosteroids Reversible posterior leukoencephalopathy syndrome after blood transfusion in a pediatric patient with sickle cell disease Neurological presentations in sickle cell patients are not always stroke: a review of posterior reversible encephalopathy syndrome in sickle cell disease Reversible posterior leuko-encephalopathy in children with sickle cell disease A case of biopsy proven acute demyelinating encephalomyelitis (ADEM) with haemorrhagic leucoencephalitis Acute encephalopathy with parvovirus B19 infection in sickle cell disease Unusual encephalopathy after acute chest syndrome in sickle cell disease: acute necrotizing encephalitis Acute hemorrhagic encephalomyelitis in childhood: case report and literature review Acute disseminated encephalomyelitis progressing to hemorrhagic encephalitis Outcome of acute necrotizing encephalopathy in relation to treatment with corticosteroids and gammaglobulin Acute encephalopathy with bilateral striatal necrosis: favourable response to corticosteroid therapy Acute hemorrhagic leukoencephalitis: recovery and reversal of magnetic resonance imaging findings in a child A review of the current literature and a guide to the early diagnosis of autoimmune disorders associated with neuromyelitis optica Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2 RANBP2 mutation and acute necrotizing encephalopathy: 2 cases and a literature review of the expanding clinico-radiological phenotype RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism Parvovirus B19 has been described to cause encephalopathy in sickle cell patients. keywords: acute; brain; cell; disease; encephalopathy; hemorrhagic; patient; ranbp2 cache: cord-294638-tuxwmv0v.txt plain text: cord-294638-tuxwmv0v.txt item: #85 of 116 id: cord-294807-1zuw3pp7 author: Khodamoradi, Zohre title: COVID-19 and Acute Pulmonary Embolism in Postpartum Patient date: 2020-08-17 words: 1257 flesch: 43 summary: Co-infection of coronavirus disease 2019 and influenza A: a report from Iran Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Pulmonary artery thrombosis in a patient with severe acute respiratory syndrome Acute pulmonary embolism and COVID-19 pneumonia: a random association? COVID-19 complicated by acute pulmonary embolism Coagulopathy and antiphospholipid antibodies in patients with Covid-19 Prevention of postpartum venous thromboembolism American College of Obstetricians and Gynecologists. Acute pulmonary embolism has been associated with severe acute respiratory syndrome coronavirus infections, but no cases have been reported with Middle East respiratory syndrome (2, 3) . keywords: coronavirus; covid-19; embolism; patient; venous cache: cord-294807-1zuw3pp7.txt plain text: cord-294807-1zuw3pp7.txt item: #86 of 116 id: cord-295206-vetdsk48 author: Woodfork, Karen title: Bronchitis date: 2008-01-10 words: 6119 flesch: 33 summary: Acute infectious bronchitis differs from chronic bronchitis with respect to etiology, pathophysiology, and treatment. As a form of chronic obstructive pulmonary disease (COPD), chronic bronchitis is characterized by irreversible or incompletely reversible airway obstruction that produces a decrease in maximal expiratory airflow Chitkara and Sarinas (2002) . keywords: bronchitis; chronic; copd; development; disease; exacerbations; individuals; infection; lung; sputum; symptoms; treatment cache: cord-295206-vetdsk48.txt plain text: cord-295206-vetdsk48.txt item: #87 of 116 id: cord-295216-eff02z0i author: Ahluwalia, Ranbir title: The impact of imposed delay in elective pediatric neurosurgery: an informed hierarchy of need in the time of mass casualty crisis date: 2020-05-20 words: 5230 flesch: 42 summary: I malformation associated with extensive syrinx Time course of syringomyelia resolution following decompression of Chiari malformation Type I Chiari I malformation associated with syringomyelia: a retrospective study of 316 surgically treated patients Comparison of posterior fossa decompression with and without duraplasty for the surgical treatment of Chiari malformation Type I in pediatric patients: a metaanalysis Pediatric epilepsy surgery: could age be a predictor of outcomes Developmental outcome after epilepsy surgery in infancy Early and late epilepsy surgery in focal epilepsies associated with long-term epilepsy-associated tumors Factors associated with seizure freedom in the surgical resection of glioneuronal tumors Dysembryoplastic neuroepithelial tumors in childhood: long-term outcome and prognostic features Epilepsy surgery for glioneuronal tumors in childhood: avoid loss of time Endoscopic versus open repair for craniosynostosis in infants using propensity score matching to compare outcomes: a multicenter study from the Pediatric Craniofacial Collaborative group Age at time of craniosynostosis repair predicts increased complication rate. [15] noted thin-walled, small, and closely packed vascularization in pediatric patients with cerebellar hemorrhage from pilocytic astrocytomas 10]. keywords: age; cases; chiari; children; epilepsy; months; patients; pediatric; surgery; syrinx cache: cord-295216-eff02z0i.txt plain text: cord-295216-eff02z0i.txt item: #88 of 116 id: cord-296605-p67twx7a author: LAU, Arthur Chun-Wing title: Management of Critically Ill Patients with Severe Acute Respiratory Syndrome (SARS) date: 2004-03-10 words: 4848 flesch: 34 summary: In this article, we aim to focus on the management of the subgroup of SARS patients who are critically ill. In one-third to half of SARS patients, fever may recur while on immunomodulatory treatment due to superimposed infections, too rapid tailing of corticosteroids or persistently severe and uninhibited cytokine storm. keywords: acute; clinical; corticosteroids; failure; icu; infection; patients; pressure; sars; syndrome; treatment; ventilation cache: cord-296605-p67twx7a.txt plain text: cord-296605-p67twx7a.txt item: #89 of 116 id: cord-302862-znnlyz3y author: Lim, Peter A.C. title: Transverse Myelitis date: 2019-04-17 words: 4788 flesch: 32 summary: Comparison of spinal cord presentations of multiple sclerosis Discriminatory features of acute transverse myelitis: a retrospective analysis of 45 patients Distinct features between longitudinally extensive transverse myelitis presenting with and without anti-aquaporin 4 antibodies Acute myelitis due to Zika virus infection Clinical and evoked potential changes in acute transverse myelitis following methyl prednisolone Residual bladder dysfunction 2 to 10 years after acute transverse myelitis Transverse myelitis in children: long-term urological outcomes Involvement of the entire spinal cord and medulla oblongata in acute catastrophic-onset transverse myelitis in SLE Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease Point: should phrenic nerve stimulation be the treatment of choice for spinal cord injury? Effective management of intractable neuropathic pain using an intrathecal morphine pump in a patient with acute transverse myelitis Effects of locomotor training after incomplete spinal cord injury: a systematic review Robot-assisted gait training (Lokomat) improves walking function and activity in people with spinal cord injury: a systematic review Powered exoskeletons for walking assistance in persons with central nervous system injuries: a narrative review Nerve transfers for restoration of upper extremity motor function in a child with upper extremity deficits due to transverse myelitis: case report Spasticity and joint contractures are common complications with spinal cord injury and management may be straightforward or extremely difficult, requiring several interventions simultaneously. keywords: acute; bladder; bowel; cord; devices; level; myelitis; nerve; pain; patient; recovery; spinal; transverse cache: cord-302862-znnlyz3y.txt plain text: cord-302862-znnlyz3y.txt item: #90 of 116 id: cord-305618-tq401g18 author: Kim, Beom Joon title: Management of Acute Stroke Patients Amid the Coronavirus Disease 2019 Pandemic: Scientific Statement of the Korean Stroke Society date: 2020-05-12 words: 1455 flesch: 40 summary: Their plans can be summarized as follows: (1) centralization of regional stroke systems of care and (2) development and implementation of protected intramural code stroke protocols to ensure the quality of stroke care and protect hospital personnel from the SARS-CoV-2 infection. Challenges and potential solutions of stroke care during the coronavirus disease 2019 (covid-19) outbreak Infection prevention and control during health care when covid-19 is suspected Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study Clinical course and outcomes of patients with severe acute respiratory syndrome coronavirus 2 infection: a preliminary report of the first 28 patients from the Korean cohort study on COVID-19 Acute cerebrovascular disease following covid-19: a single center, retrospective, observational study Neurological manifestations of hospitalized patients with covid-19 in Wuhan, China: a retrospective case series study Temporary emergency guidance to US stroke centers during the COVID-19 pandemic Menon BK. keywords: acute; covid-19; patients; stroke cache: cord-305618-tq401g18.txt plain text: cord-305618-tq401g18.txt item: #91 of 116 id: cord-305856-xt3zxajf author: Shanmugam, Chandrakumar title: COVID-2019 – A comprehensive pathology insight date: 2020-09-18 words: 4607 flesch: 32 summary: The earliest case of SARS CoV-2 infection currently known was reported on 31st December 2019 in Wuhan, Hubei province of China. Furthermore, SARS CoV-2 infection in pregnant women raised a possibility of vertical transmission. keywords: cases; china; coronavirus; covid-19; disease; infection; novel; pathology; patients; pneumonia; sars; syndrome; transmission cache: cord-305856-xt3zxajf.txt plain text: cord-305856-xt3zxajf.txt item: #92 of 116 id: cord-308201-lavcsqov author: Desforges, Marc title: Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? date: 2019-12-20 words: 8478 flesch: 27 summary: These criteria certainly represent a pertinent tool to evaluate the involvement of human respiratory viruses as a factor that could influence long-term human neurological diseases. Nevertheless, our data suggest that HCoV-OC43 may also invade the CNS from the external environment through other pathways involving other cranial peripheral nerves [269] , reminiscent of what was shown for other human respiratory viruses such as RSV and influenza virus [8] . keywords: acute; cns; coronavirus; diseases; encephalitis; hcov; human; infection; influenza; mice; oc43; patients; respiratory; syndrome; system; term; tract; viruses cache: cord-308201-lavcsqov.txt plain text: cord-308201-lavcsqov.txt item: #93 of 116 id: cord-310205-j57x9ke6 author: Alcaide, Maria L. title: Pharyngitis and Epiglottitis date: 2007-06-08 words: 7569 flesch: 39 summary: The role of streptococcus in the pathogenesis of rheumatic fever Rapid diagnosis of pharyngitis caused by group A streptococci Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis Management of acute pharyngitis in adults: reliability of rapid streptococcal tests and clinical findings Treatment failures and carriers: perception or problems? Antibiotics for sore throat Are cephalosporins superior to penicillin for treatment of acute streptococcal pharyngitis? Principles of appropriate antibiotic use of acute pharyngitis in adults Antibiotic treatment of children with sore throat Antibiotic treatment of adults with sore throat by community primary care physicians: a national survey Clinical significance and pathogenesis of viral respiratory infections A collaborative study of the aetiology of acute respiratory infection in Britain 1961-4. keywords: acute; adults; cases; children; disease; fever; gas; group; infection; patients; pharyngitis; streptococcal; therapy; throat; treatment cache: cord-310205-j57x9ke6.txt plain text: cord-310205-j57x9ke6.txt item: #94 of 116 id: cord-311529-tv324cx1 author: Fromont, A. title: Encefalomielite acuta disseminata date: 2010-12-31 words: 8192 flesch: 49 summary: [87] , di tromboflebiti cerebrali, il cui rischio aumenta in caso di realizzazione di una PL sotto steroidi, di scompenso di diabete, di ipokaliemia con il rischio di disturbi del ritmo cardiaco, di ipertensione arteriosa, di flush cutanei e di disturbi psichiatrici. La causa principale di infezione batterica coinvolta nello sviluppo di EMAD è il micoplasma keywords: acute; alcuni; anni; bambini; casi; caso; centrale; cerebrale; che; con; criteri; cui; deficit; degli; dei; dell'emad; della; diagnosi; disseminata; disturbi; dopo; emad; encefalomielite; encephalomyelitis; essere; gli; hanno; lesioni; media; multipla; nel; nervoso; non; pazienti; più; possono; può; questi; rischio; sclerosi; secondo; segni; sistema; sono; sostanza; spesso; studio; sua; tra; tuttavia; una; uno; virus cache: cord-311529-tv324cx1.txt plain text: cord-311529-tv324cx1.txt item: #95 of 116 id: cord-313253-um3qu8xr author: Magnani, Silvia title: Acute myocarditis: an overview on emerging evidence date: 2020-07-18 words: 1075 flesch: 33 summary: Although endomyocardial biopsy still represents the gold standard, the diagnosis of acute myocarditis currently relies on several clinical and imaging criteria. In this issue of Trends in Cardiovascular Medicine, Ammirati et al. systematically review all the available evidence from observational registries on acute myocarditis with special attention to the areas in which we have a substantial lack of knowledge. keywords: acute; heart; myocarditis cache: cord-313253-um3qu8xr.txt plain text: cord-313253-um3qu8xr.txt item: #96 of 116 id: cord-315598-qwh72inx author: Mendoza, Jose Luis Accini title: ACTUALIZACION DE LA DECLARACIÓN DE CONSENSO EN MEDICINA CRITICA PARA LA ATENCIÓN MULTIDISCIPLINARIA DEL PACIENTE CON SOSPECHA O CONFIRMACIÓN DIAGNÓSTICA DE COVID-19 date: 2020-10-06 words: 69660 flesch: 31 summary: y los que tienen menos probabilidades de beneficiarse (él «demasiado enfermo»), no prestan suficiente atención a las diferencias entre grupos en términos de la duración de los cuidados intensivos necesarios para lograr resultados. Se recomienda aplicar la escala SOFA al menos cada 48 horas sumado al criterio de fragilidad y años de vida saludables salvados estos criterios podrían ser válidos en pacientes con fallo terapéutico a las medidas óptimas y orientar decisiones de deescalamiento de medidas y de nivel de complejidad de atención cuando la demanda potencial supera la oferta (capacidad y capacidades), estas decisiones deben ser tomadas idealmente en junta médica. keywords: 2019; 2020; acuerdo con; acute; además de; aguda; alto; amci; analysis; análisis de; asociado con; aumento de; bajo; calidad de; care; casos de; clinical; clínica; clínica de; clínicos; comité de; como el; como la; como los; como se; como una; compromiso; con covid-19; con el; con enfermedad; con hipoxemia; con infección; con la; con los; con mayor; con neumonía; con que; con sars; con sdra; con sospecha; con su; con un; condiciones de; considerar la; contar con; contra; control; coronavirus; cov-2; criterios de; crítico con; cual se; cuando se; cuenta la; de acuerdo; de aerosoles; de alta; de amci; de atención; de baja; de cada; de contaminación; de coronavirus; de covid-19; de cuidados; de de; de dificultad; de enfermedad; de esta; de estos; de estudios; de falla; de forma; de hcq; de hipoxemia; de il-6; de infección; de ingreso; de intubación; de la; de los; de manera; de marzo; de menor; de oxígeno; de pacientes; de protección; de salud; de ser; de soporte; de su; de tórax; de un; de ventilación; de vida; deben; del; del virus; dentro; desde el; después de; diagnóstico de; disease; disminución de; disminuir el; disponibilidad de; distress; donde; dosis; dosis de; duración de; durante la; días; días de; el consentimiento; el cual; el de; el diagnóstico; el día; el estudio; el grupo; el inicio; el manejo; el momento; el más; el nivel; el número; el paciente; el pronóstico; el riesgo; el sars; el tiempo; el traslado; el uso; elevación de; embargo; en china; en contra; en cuenta; en el; en este; en la; en los; en salud; en su; en uci; en un; entre el; entre la; entre los; es una; estado de; este; estrategia de; está; evidencia de; evitar la; fin de; final de; fue de; fuera de; fueron; grupo de; hasta el; horas; infección por; inicio de; intensive; la administración; la capacidad; la cual; la decisión; la disponibilidad; la enfermedad; la evidencia; la falla; la hcq; la hipoxemia; la infección; la intubación; la mortalidad; la oxigenación; la pandemia; la presencia; la presión; la relación; la respuesta; la salud; la seguridad; la terapia; la toma; la uci; la utilización; la valoración; la vida; la vía; las; los casos; los cuales; los días; los estudios; los síntomas; luego de; manejo de; mayor; mayoría de; mecánica; medición de; medidas de; mejorar la; mejoría; menor; más de; necesidad de; nivel de; niveles; número de; o por; o se; objetivo de; otros; pacientes con; pacientes covid-19; pacientes críticos; pacientes que; pacientes y; para el; para la; para los; para pacientes; para que; para sars; para su; parte de; patients; pcr; pero; personal de; plasma; por covid-19; por el; por la; por los; por sars; por un; posibilidad de; presión; protocolo de; pueden; pulmonar; punto de; que; que el; que la; que los; que puede; que se; que una; realización de; realizar; recomendación se; recomienda la; recomienda que; reducción de; renal; respiratoria; resultados; retiro de; review; riesgo de; salud y; sars; se debe; se han; se puede; se recomienda; según la; ser; severa; severidad de; shock; si el; si la; si se; sin; sobre el; sobre la; son de; sospecha de; syndrome; síndrome de; tasa de; tener; tener en; teniendo en; tiempo de; tipo de; todos los; tormenta de; trabajadores de; tratamiento de; treatment; uci y; un estudio; un paciente; una; unidad de; uso de; utilizar; ventilation; viral; y al; y cols; y como; y con; y de; y el; y en; y es; y la; y los; y para; y por; y puede; y que; y se; y su; y una cache: cord-315598-qwh72inx.txt plain text: cord-315598-qwh72inx.txt item: #97 of 116 id: cord-318277-j073u7ga author: Sapey, Elizabeth title: Building toolkits for COPD exacerbations: lessons from the past and present date: 2019-07-03 words: 7248 flesch: 29 summary: a post hoc cohort analysis from the Summit randomized clinical trial Increased platelet activation in patients with stable and acute exacerbation of COPD Cardiovascular risk, myocardial injury, and exacerbations of chronic obstructive pulmonary disease Cognitive dysfunction in patients hospitalized with acute exacerbation of COPD Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD Audit programme: outcomes from the clinical audit of COPD exacerbations admitted to acute units in England Susceptibility to exacerbation in chronic obstructive pulmonary disease Acute kidney injury in stable COPD and at exacerbation Bedside assessment of quadriceps muscle by ultrasound after admission for acute exacerbations of chronic respiratory disease Validation of the DECAF score to predict hospital mortality in acute exacerbations of COPD I Notes on Xrays Ueber die isolierte Farbung Der Schizomyceten in Schmitt-und Trockenpraparaten On consumption, on certain diseases of the lungs and pleura Infection in the pathogenesis and course of chronic obstructive pulmonary disease Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease Major air pollutants and risk of COPD exacerbations: a systematic review and meta-analysis Adherence to inhaled therapy, mortality and hospital admission in COPD Socioeconomic status, race and COPD health outcomes Physiological changes during symptom recovery from moderate exacerbations of COPD Venous thromboemboli and exacerbations of COPD Diagnosis of myocardial infarction following hospitalisation for exacerbation of COPD Relationship of sputum color to nature and outpatient management of acute exacerbations of COPD Sputum colour reported by patients is not a reliable marker of the presence of bacteria in acute exacerbations of chronic obstructive pulmonary disease Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers The pathogenesis of bronchial catarrk and of acute and chronic bronchitis Acute and chronic inflammation of the bronchial tree Inter-relationships between inflammatory markers in patients with stable COPD with bronchitis: Intra-patient and inter-patient variability Variability of sputum inflammatory mediators in COPD and alpha1-antitrypsin deficiency Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations Increased bronchoalveolar granulocytes and granulocyte/macrophage colony-stimulating factor during exacerbations of chronic bronchitis Changes in T-lymphocyte subpopulations at the onset of severe exacerbations of chronic obstructive pulmonary disease Aberrant neutrophil functions in stable chronic obstructive pulmonary disease: the neutrophil as an immunotherapeutic target neutrophil elastase cleaves C3bi keywords: acute; chronic; copd; disease; exacerbations; inflammation; lung; patients; risk; sputum; studies; symptoms; therapy; time; treatment cache: cord-318277-j073u7ga.txt plain text: cord-318277-j073u7ga.txt item: #98 of 116 id: cord-323566-jck799zq author: Cheung, Oi-Yee title: Acute Lung Injury date: 2017-11-05 words: 8319 flesch: 34 summary: Other histologic features of acute lung injury include intraalveolar fibrin, organization, interstitial edema, and reactive pneumocytes. Diffuse alveolar damage and other histologic features of acute lung injury are nonspecific as to etiology, and once identified require the pathologist to search the biopsy for further features that may help identify a specific etiology. keywords: acute; alveolar; biopsy; cases; cause; dad; diffuse; disease; fig; infection; injury; lung; patients; pneumonia; pulmonary; syndrome cache: cord-323566-jck799zq.txt plain text: cord-323566-jck799zq.txt item: #99 of 116 id: cord-324810-92fosk3c author: Sharma, Sat title: Role of Antimicrobial Agents in the Management of Exacerbations of COPD date: 2012-08-23 words: 9362 flesch: 33 summary: Antimicrob Agents sis of risk factors for infection due to penicillin resistant and multidrug resistant Chemother the treatment of acute exacerbation of chronic bronchitis: results of a randomized, double-blind study Randomized, double-blind study comparing 5-and 7-treatment of adults with lower respiratory tract infections and effects on long day regimens of oral levofloxacin in patients with acute exacerbations of term outcome Comparison of 5-day, short cause azithromycin levofloxacin in the outpatient treatment of acute bacterial exacerbations of 97-107 chronic bronchitis Efficacy and tolerability of gatifloxacin A comparison of 5-day courses of in community treatment of acute exacerbations of chronic bronchitis. J Int ment of patients with acute bacterial exacerbation of chronic bronchitis Studio Multicentrico con Moxifloxacina nel release clarithromycin tablets and amoxicillin/clavulanate tablets in the treat-Trattamento delle Riacutizzazioni de Bronchite Cronica Short-term and long-term outcomes of comparative study of clarithromycin modified release and amoxicillin/clavumoxifloxacin compared to standard antibiotic treatment in acute exacerbations lanic acid in the treatment of acute exacerbation of chronic bronchitis A review of the comparative in vitro activities of 12 antimicrobial agents, with a focus on five new respiratory quinolones. keywords: acute; aecopd; antimicrobial; bacterial; bronchitis; chronic; disease; exacerbations; failure; influenzae; patients; resistance; sputum; study; therapy; treatment cache: cord-324810-92fosk3c.txt plain text: cord-324810-92fosk3c.txt item: #100 of 116 id: cord-325405-cu4nx891 author: Luo, Lingfei title: Epidemiological and clinical differences between sexes and pathogens in a three-year surveillance of acute infectious gastroenteritis in Shanghai date: 2019-07-10 words: 4193 flesch: 25 summary: Of the identified cases of bacterial acute gastroenteritis, 72.4%, 22.2%, 1.1% and 0.4% were infected by Vibrio parahemolyticus, Salmonella, EPEC and ETEC alone, respectively; 3.6%, 0.1% and 0.1% were coinfected by Vibrio parahemolyticus and Salmonella, EPEC and Vibrio parahemolyticus and EPEC and Salmonella, respectively (Fig. 2) . Thus, higher prevalence of fever and abdominal pain in acute bacterial gastroenteritis were observed. keywords: acute; analyses; cases; cell; factors; gastroenteritis; males; sex; vomiting cache: cord-325405-cu4nx891.txt plain text: cord-325405-cu4nx891.txt item: #101 of 116 id: cord-330919-dep3v1pt author: Whyte, Claire S title: Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID‐19 date: 2020-04-23 words: 4261 flesch: 30 summary: A Case Series Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism Tissue plasminogen activator (tPA) inhibits interleukin-1 induced acute lung leak Heuze-Vourc'h N. Designing inhaled protein therapeutics for topical lung delivery: what are the next steps? Effects of nebulized antithrombin and heparin on inflammatory and coagulation alterations in an acute lung injury model in rats Aerosolized anticoagulants ameliorate acute lung injury in sheep after exposure to burn and smoke inhalation Heparin nebulization attenuates acute lung injury in sepsis following smoke inhalation in sheep Nebulized anticoagulants in lung injury in critically ill patients-an updated systematic review of preclinical and clinical studies Streptokinase Versus Unfractionated Heparin Nebulization in Patients With Severe Acute Respiratory Distress Syndrome (ARDS): PAR signalling can enhance inflammation in acute lung injury (ALI) by increasing the expression of pro-inflammatory cytokines, including IL-6 keywords: acute; ards; covid-19; distress; fibrin; injury; lung; patients; plasminogen; syndrome cache: cord-330919-dep3v1pt.txt plain text: cord-330919-dep3v1pt.txt item: #102 of 116 id: cord-331910-s474ecvk author: Thota, Sai Manohar title: Natural products as home‐based prophylactic and symptom management agents in the setting of COVID‐19 date: 2020-08-17 words: 8699 flesch: 22 summary: Drug Design A trial of Lopinavir-Ritonavir in adults hospitalized with severe Covid-19 Vitamin C and immune function Features, evaluation and treatment coronavirus (COVID-19) Vitamin C in disease prevention and cure: An overview Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines Effects of curcumin on pulmonary fibrosis and functions of paraquatchallenged rats Apigenin protects against bleomycin-induced lung fibrosis in rats Protective roles of Cordyceps on lung fibrosis in cellular and rat models β-Patchoulene from patchouli oil protects against LPSinduced acute lung injury via suppressing NF-κB and activating Nrf2 pathways Oxidative stress and pulmonary fibrosis Naja naja atra venom ameliorates pulmonary fibrosis by inhibiting inflammatory response and oxidative stress β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transition Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: A retrospective study Does Carica papaya leaf-extract increase the platelet count? Neem (Azadirachta indica) has potential therapeutic benefits against pulmonary fibrosis pulmonary inflammation, acute lung injury, and alveolar damage. keywords: acute; antioxidant; bleomycin; cells; coronavirus; covid-19; effects; et al; fibrosis; infection; injury; levels; lung; mice; patients; rats; sars; study; symptoms; syndrome; tgf cache: cord-331910-s474ecvk.txt plain text: cord-331910-s474ecvk.txt item: #103 of 116 id: cord-331939-6okbdw7a author: Sin, David title: Acute pulmonary embolism multimodality imaging prior to endovascular therapy date: 2020-08-30 words: 7405 flesch: 35 summary: A simple score for rapid risk assessment of non-high-risk pulmonary embolism Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis A pulmonary embolism response team (PERT) approach: initial experience from the Cleveland Clinic Pulmonary embolism response teams Impact of multidisciplinary pulmonary embolism response team availability on management and outcomes Endovascular therapy for acute pulmonary embolism Endovascular therapy for acute severe pulmonary embolism A prospective, single-arm, multicenter trial of ultrasound-facilitated, catheter-directed, low-dose fibrinolysis for acute massive and submassive pulmonary embolism: the SEATTLE II Study Randomized, controlled trial of ultrasound-assisted catheter-directed thrombolysis for acute intermediate-risk pulmonary embolism Catheter-tip embolectomy in the management of acute massive pulmonary embolism Catheter-directed therapy for the treatment of massive pulmonary embolism: systematic review and meta-analysis of modern techniques Pulmonary embolism response to fragmentation, embolectomy, and catheter thrombolysis (PER-FECT): initial results from a prospective multicenter registry A randomized trial of the optimum duration of acoustic pulse thrombolysis procedure in acute intermediate-risk pulmonary embolism: The OPTALYSE PE Trial Management of suspected acute pulmonary embolism in the era of CT angiography: a statement from the Fleischner Society Suspected acute pulmonary embolism: evaluation with multi-detector row CT versus digital subtraction pulmonary arteriography Dual-energy CT of the heart for diagnosing coronary artery stenosis and myocardial ischemia-initial experience Update on cardiovascular applications of multienergy CT State of the art: utility of multi-energy CT in the evaluation of pulmonary vasculature Dual-energy CT: spectrum of thoracic abnormalities Dualenergy CT: clinical applications in various pulmonary diseases Chronic thromboembolic pulmonary hypertension Dual-energy CT (DECT) lung perfusion in pulmonary hypertension: concordance rate with V/Q scintigraphy in diagnosing chronic thromboembolic pulmonary hypertension (CTEPH) Dual-energy MDCT: comparison of pulmonary artery enhancement on dedicated CT pulmonary angiography, routine and low contrast volume studies The indeterminate CT pulmonary angiogram: imaging characteristics and patient clinical outcome Prognostic value of perfusion defect volume at dual energy CTA in patients with pulmonary embolism: correlation with CTA obstruction scores, CT parameters of right ventricular dysfunction and adverse clinical outcome Spectral optimization of chest CT angiography with reduced iodine load: experience in 80 patients evaluated with dual-source, dual-energy CT Low-contrast agent dose dual-energy CT monochromatic imaging in pulmonary angiography versus routine CT High-pitch computed tomography pulmonary angiography with iterative reconstruction at 80 kVp and 20 mL contrast agent volume High pitch, low voltage dual source CT pulmonary angiography: assessment of image quality and diagnostic acceptability with hybrid iterative reconstruction State-of-the-art pulmonary CT angiography for acute pulmonary embolism Iterative reconstruction and automatic tube voltage selection reduce clinical CT radiation doses and image noise CT pulmonary angiography: dose reduction via a next generation iterative reconstruction algorithm Multidetector computed tomography for acute pulmonary embolism: diagnosis and risk stratification in a single test Dual-energy CT for imaging of pulmonary hypertension: challenges and opportunities Comparative assessment of qualitative and quantitative perfusion with dual-energy CT and planar and SPECT-CT V/Q scanning in patients with chronic thromboembolic pulmonary hypertension Lung perfused blood volume images with dual-energy computed tomography for chronic thromboembolic pulmonary hypertension: correlation to scintigraphy with singlephoton emission computed tomography Severity assessment of pulmonary embolism using dual energy CT-correlation of a pulmonary perfusion defect score with clinical and morphological parameters of blood oxygenation and right ventricular failure Advanced imaging in pulmonary hypertension: emerging techniques and applications Imaging in chronic thromboembolic pulmonary hypertension Reference values for normal pulmonary artery dimensions by noncontrast cardiac computed tomography: the Framingham Heart Study Prediction of pulmonary hypertension in patients with or without interstitial lung disease: reliability of CT findings A CT sign of chronic pulmonary arterial hypertension: the ratio of main pulmonary artery to aortic diameter Signs of right ventricular dysfunction: prognostic role in acute pulmonary embolism Predictive value of computed tomography in acute pulmonary embolism: systematic review and meta-analysis Computed tomography to assess risk of death in acute pulmonary embolism: a meta-analysis Indeterminate CT pulmonary angiogram: why and does it matter Yield of CT pulmonary angiography in the diagnosis of acute pulmonary embolism: short report Suboptimal CT pulmonary angiography in the emergency department: a retrospective analysis of outcomes in a large academic medical center Comparison of interpretations of CT angiograms in the evaluation of suspected pulmonary embolism by on-call radiology fellows and subsequently by radiology faculty Diagnosis of acute pulmonary embolism in outpatients: comparison of thin-collimation multi-detector row spiral CT and planar ventilation-perfusion scintigraphy Prospective comparison of helical CT with angiography in pulmonary embolism: global and selective vascular territory analysis. for the Clinical Guidelines Committee of the American College of Physicians (2015) Evaluation of patients with suspected acute pulmonary embolism: best practice advice from the Clinical Guidelines Committee of the American College of Physicians Task Force for the Diagnosis, and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC) (2014) 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism keywords: acute; angiography; contrast; ctpa; embolism; energy; images; imaging; patients; perfusion; pulmonary; right; risk; study cache: cord-331939-6okbdw7a.txt plain text: cord-331939-6okbdw7a.txt item: #104 of 116 id: cord-333696-3ci9re9a author: Alomari, Safwan O. title: COVID-19 and the Central Nervous System date: 2020-08-04 words: 4426 flesch: 40 summary: We believe that this association between smoking and COVID-19 neurological manifestations, if proven, might be of great impact, since all the people worldwide are currently at high risk of being exposed to smoking and COVID-19 infection. Patients with COVID-19 infection should be evaluated early for neurological symptoms. keywords: acute; brain; case; coronavirus; cov-2; covid-19; disease; encephalitis; infection; patients; sars cache: cord-333696-3ci9re9a.txt plain text: cord-333696-3ci9re9a.txt item: #105 of 116 id: cord-334528-xenq90xj author: Chen, Hsing I title: Acute lung injury and acute respiratory distress syndrome: experimental and clinical investigations date: 2011-03-17 words: 5315 flesch: 29 summary: I. Light microscopy Ventilator-induced lung injury Cellular stress failure in ventilator-injured lungs Acute respiratory distress syndrome: a historical perspective The acute respiratory distress syndrome Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management Leukocyte elastase: physiological functions and role in acute lung injury Roles of neutrophil elastase and superoxide anion in leukotriene B4-induced lung injury in rabbit Chemokines in acute respiratory distress syndrome Transcriptional mechanisms of acute lung injury Alveolar epithelial fluid transport in acute lung injury: new insights Mechanisms of pulmonary edema clearance Perspective on lung injury and recruitment: a skeptical look at the opening and collapse story Critical care in AJRCCM Alveolar recruitment in acute lung injury Prone position augments recruitment and prevents alveolar overinflation in acute lung injury Hypercapnic acidosis attenuates endotoxin-induced acute lung injury Protective effects of hypercapnic acidosis on ventilator-induced lung injury Permissive hypercapnia: role in protective lung ventilatory strategies Hypercapnia via reduced rate and tidal volume contributes to lipopolysaccharide-induced lung injury Permissive hypercapnia impairs pulmonary gas exchange in the acute respiratory distress syndrome Nonventilatory treatments for acute lung injury and ARDS Ventilatory management of acute lung injury and acute respiratory distress syndrome Acute respiratory distress syndrome: pharmacological treatment options in development Pathophysiology and pharmacological treatment of pulmonary hypertension in acute respiratory distress syndrome Inhaled nitric oxide therapy in adults Exercise training attenuates septic responses in conscious rats Vascular endothelial growth factor and related molecules in acute lung injury Angiotensin-converting enzyme 2 protects from severe acute lung failure Insulin attenuates endotoxin-induced acute lung injury in conscious rats Comparison of propofol and midazolam for sedation in critically ill patients An update of its use in anaesthesia and conscious sedation The reduction of tumor necrosis factor-alpha release and tissue damage by pentobarbital in the experimental endotoxemia model N-acetylcysteine ameliorates lipopolysaccharide-induced organ damage in conscious rats Post-treatment with N-acetylcysteine ameliorates endotoxin shock-induced organ damage in conscious rats N-Acetylcysteine treatment to prevent the progression of multisystem organ failure: a prospective, randomized, placebo-controlled study Antioxidant supplementation in sepsis and systemic inflammatory response syndrome N-acetylcysteine as the magic bullet: too good to be true Experimental studies and clinical investigations were supported in part by grants from the National Science Council. [77, 78] Intratracheal instillation of hydrochloric acid (HCI) or gastric particles has been employed as experimental model of acute lung injury (ALI). keywords: acid; acute; ali; ards; distress; injury; inos; lung; nitric; oxide; pulmonary; rats; syndrome cache: cord-334528-xenq90xj.txt plain text: cord-334528-xenq90xj.txt item: #106 of 116 id: cord-336053-cjq7szcn author: Mottola, Filiberto Fausto title: Cardiovascular System in COVID-19: Simply a Viewer or a Leading Actor? date: 2020-08-27 words: 5641 flesch: 37 summary: Patients: Awareness of an Increased Prevalence Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia Sanchis-Gomar, F. Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): Evidence from a meta-analysis Cardiovascular Implications of Fatal Outcomes of Patients with Coronavirus Disease 2019 (COVID-19) Clinical features of patients infected with 2019 novel coronavirus in Association of Coronavirus Disease 2019 (COVID-19) with Myocardial Injury and Mortality SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS Acute myocarditis associated with novel Middle East respiratory syndrome coronavirus The Variety of Cardiovascular Presentations of COVID-19 Coinvolgimento cardiaco in un paziente con malattia coronavirus 2019 (COVID-19) Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems during the COVID-19 Pandemic Influenza epidemics and acute respiratory disease activity are associated with a surge in autopsy-confirmed coronary heart disease death: Results from 8 years of autopsies in 34 892 subjects Seasonal Influenza Infections and Cardiovascular Disease Mortality COVID-19 and the cardiovascular system Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study SARS-CoV-2: A potential novel etiology of fulminant myocarditis Characteristics and Outcomes of Recipients of Heart Transplant with Coronavirus Disease European Heart Rhythm Association (EHRA) consensus document on management of arrhythmias and cardiac electronic devices in the critically ill and post-surgery patient, endorsed by Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), Cardiac Arrhythmia Society of Southern Africa (CASSA), and Latin American Heart Rhythm Society (LAHRS) Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy Systemic inflammation and arrhythmic risk: Lessons from rheumatoid arthritis Cardioimmunology of arrhythmias: The role of autoimmune and inflammatory cardiac channelopathies Cardiotoxicity of antimalarial drugs Drug-induced ventricular tachycardia Heart conduction disorders in long-term treatment with chloroquine. While ECG monitoring is always available for COVID-19 patients admitted to ICU, in patients hospitalized in non-intensive rooms, clinicians should monitor QT-intervals according to the risk factors. keywords: acute; cardiac; coronavirus; covid-19; damage; disease; heart; increase; infection; patients; risk; sars cache: cord-336053-cjq7szcn.txt plain text: cord-336053-cjq7szcn.txt item: #107 of 116 id: cord-336159-w646qkjz author: Chen, Wei title: Incidence and Outcomes of Acute Respiratory Distress Syndrome: A Nationwide Registry-Based Study in Taiwan, 1997 to 2011 date: 2015-10-30 words: 3584 flesch: 46 summary: An attempt to validate the modification of the American-European consensus definition of acute lung injury/acute respiratory distress syndrome by the Berlin definition in a university hospital Race and gender differences in acute respiratory distress syndrome deaths in the United States: an analysis of multiple-cause mortality data (1979-1996) Alveolar fluid clearance is faster in women with acute lung injury compared to men Cigarette smoke exposure and the acute respiratory distress syndrome Active and passive cigarette smoking and acute lung injury after severe blunt trauma Smoking behaviour in Taiwan The acute respiratory distress syndrome Epidemiology of acute lung injury and acute respiratory distress syndrome Mortality rates for patients with acute lung injury/ARDS have decreased over time Eight-year trend of acute respiratory distress syndrome: a population-based study in Olmsted County, Minnesota Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983-1993 Acute respiratory distress syndrome: epidemiology and management approaches The Acute Respiratory Distress Syndrome Network. Definitions, mechanisms, relevant outcomes, and clinical trial coordination The acute respiratory distress syndrome Incidence and outcomes of acute lung injury Clinical epidemiology of acute lung injury and acute respiratory distress syndrome: incidence, diagnosis, and outcomes Impact of distinct definitions of acute lung injury on its incidence and outcomes in Brazilian ICUs: prospective evaluation of 7,133 patients One-year outcomes in survivors of the acute respiratory distress syndrome Functional disability 5 years after acute respiratory distress syndrome Adult respiratory distress syndrome: a systemic overview of incidence and risk factors Incidence of the adult respiratory distress syndrome in the state of Utah Adult respiratory distress syndrome: how many cases in the UK? Incidence, severity, and mortality of acute respiratory failure in Incidence and mortality after acute respiratory failure and acute respiratory distress syndrome in Sweden, Denmark, and Iceland. keywords: acute; ards; incidence; mortality; study; syndrome; years cache: cord-336159-w646qkjz.txt plain text: cord-336159-w646qkjz.txt item: #108 of 116 id: cord-336309-j3dydo55 author: Ahmed, Khalid title: Acute abdomen is not always surgical amid the COVID‐19 pandemic date: 2020-08-05 words: 445 flesch: 42 summary: With the causes mentioned above in mind, it is wise to keep a broad differential of non-surgical causes of acute abdomen in the setting of SARS-CoV-2 infection, to avoid unnecessary surgical interventions 5 . Br J Surg DOI: 10.1002/bjs.11883 sha: doc_id: 336309 cord_uid: j3dydo55 nan Lima et al.'s recently published paper discussed the role of imaging in the diagnosis of acute abdomen cases amid the COVID-19 era 1 . keywords: abdomen; causes cache: cord-336309-j3dydo55.txt plain text: cord-336309-j3dydo55.txt item: #109 of 116 id: cord-337137-0ey40gzw author: Lo, Anthony WI title: How the SARS coronavirus causes disease: host or organism? date: 2005-12-17 words: 5203 flesch: 40 summary: CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus Chemokine upregulation in SARS coronavirus infected human monocyte derived dendritic cells DC-SIGN: escape mechanism for pathogens Molecular epidemiology of SARS -from Amoy Gardens to Taiwan Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China The Genome sequence of the SARSassociated coronavirus Characterization of a novel coronavirus associated with severe acute respiratory syndrome A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis Characterization of a unique group-specific protein (U122) of the severe acute respiratory syndrome coronavirus Specific epitopes of the structural and hypothetical proteins elicit variable humoral responses in SARS patients The 3a protein of severe acute respiratory syndromeassociated coronavirus induces apoptosis in Vero E6 cells The severe acute respiratory syndrome coronavirus 3a is a novel structural protein Severe acute respiratory syndrome coronavirus 3a protein is a viral structural protein Identification of a novel protein 3a from severe acute respiratory syndrome coronavirus The severe acute respiratory syndrome coronavirus 3a protein up-regulates expression of fibrinogen in lung epithelial cells Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway The pulmonary physician in critical care * Here, we review the pathology of SARS infection. keywords: acute; cells; coronavirus; cov; disease; infection; lung; patients; proteins; sars; syndrome cache: cord-337137-0ey40gzw.txt plain text: cord-337137-0ey40gzw.txt item: #110 of 116 id: cord-339303-feiy6xed author: Tan, Xiaodong title: Severe Acute Respiratory Syndrome epidemic and change of people's health behavior in China date: 2004-10-17 words: 1735 flesch: 51 summary: Three multiple-choice questions about SARS knowledge addressed the nature of transmission (whether it was infectious and the route of transmission) and the clinical symptoms. The adoption of these measures, due to the initially unclear nature of SARS transmission, actually increased panic among the Chinese people who began wearing masks, reducing the chances of outdoor activities, disinfecting the environment and washing their hands. keywords: health; people; sars; syndrome cache: cord-339303-feiy6xed.txt plain text: cord-339303-feiy6xed.txt item: #111 of 116 id: cord-339686-oybnk1j8 author: Suassuna, José Hermógenes Rocco title: Technical note and clinical instructions for Acute Kidney Injury (AKI) in patients with Covid-19: Brazilian Society of Nephrology and Brazilian Association of Intensive Care Medicine date: 2020-08-26 words: 5774 flesch: 37 summary: These data did not suggest a higher incidence of AKI in patients with Covid-19 when compared to other patients with the same severity profile 17 . For this reason, there was an initial recommendation to restrict the entry of nephrologists and dialysis nurses in the cohorts allocated Covid-19 patients. keywords: acute; aki; care; cases; clinical; cov-2; covid-19; dialysis; injury; kidney; patients; renal; risk; rrt; sars cache: cord-339686-oybnk1j8.txt plain text: cord-339686-oybnk1j8.txt item: #112 of 116 id: cord-343637-3g4tosjx author: Tumlinson, Anne title: Post‐Acute Care Preparedness in a COVID‐19 World date: 2020-05-21 words: 2845 flesch: 38 summary: Post-acute care includes long-term acute care hospitals (LTACHs) that provide hospital-level care for medically complex patients; inpatient rehabilitation facilities (IRFs) that provide hospital-level intense medical rehabilitation focused on restoring functional independence for individuals with disabilities resulting from an injury, illness, or medical condition; skilled nursing facilities (SNFs) that provide skilled nursing, medical management, and therapy services to individuals who do not require services provided in a hospital; and home health agencies (HHAs) that provide skilled care delivered by healthcare professionals in the patient's home for the treatment of a medical condition, illness, or disability. We have adapted their framework to reflect the realm of post-acute care: keywords: acute; care; covid-19; health; hospital; patients; providers cache: cord-343637-3g4tosjx.txt plain text: cord-343637-3g4tosjx.txt item: #113 of 116 id: cord-345222-otfnrarh author: Ciccarelli, Simona title: Management strategies in the treatment of neonatal and pediatric gastroenteritis date: 2013-10-29 words: 14626 flesch: 33 summary: 107, 108 The protective effects of breastfeeding against gastroenteritis infections have been demonstrated in several studies. 13 Prevention is essential, and all health professionals should ensure caregiver education in the following main principles of prevention: 13 • Full and exclusive breastfeeding that protects against intestinal infections and prevents exposure to environmental contamination. keywords: acute; age; cases; cause; children; coli; diarrhea; disease; gastroenteritis; human; infants; infection; patients; probiotics; pylori; resistance; risk; rotavirus; shigella; stool; strains; study; symptoms; therapy; treatment; vomiting; years cache: cord-345222-otfnrarh.txt plain text: cord-345222-otfnrarh.txt item: #114 of 116 id: cord-349197-3trr8d0u author: Ventura, Francesco title: Two Fatal Cases of Hidden Pneumonia in Young People date: 2010-04-28 words: 2510 flesch: 34 summary: Definitions, mechanisms, relevant outcomes, and clinical trial coordination Irwin and Rippe's intensive care medicine, 5th edn Abbas AK Robbins and Cotran pathologic basis of disease Nonhomogeneous immunostaining of hyaline membranes in different manifestations of diffuse alveolar damage The acute respiratory distress syndrome Mechanisms of sepsis-induced organ dysfunction Sepsis Definitions Conference A multicenter registry of patients with acute respiratory distress syndrome. Results from the ALIVE study Post-mortem diagnosis of sepsis Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults Incidence, clinical course, and outcome in 217 patients with acute respiratory distress syndrome The authors thank Prof. Vittorio Fineschi for his help in histological and immunohistochemical studies. keywords: ards; cases; distress; lung; pneumonia; syndrome cache: cord-349197-3trr8d0u.txt plain text: cord-349197-3trr8d0u.txt item: #115 of 116 id: cord-353717-jjd90fyh author: Singhavi, Ravi title: A Case of Hemolytic Anemia With Acute Myocarditis and Cardiogenic Shock: A Rare Presentation of COVID-19 date: 2020-09-25 words: 1463 flesch: 37 summary: In the context of cardiac involvement, acute myocarditis has become one of the unexplored areas in COVID-19 patients, which could influence the long-term outcomes. In this report, we presented a case of a COVID-19 patient who developed acute myocarditis and severe acute hemolytic anemia, as evident from peripheral blood smear showing schistocytes (fragmented RBCs) in peripheral smear with acute severe anemia along with elevated LDH, which is also a surrogate marker for hemolysis. keywords: acute; anemia; covid-19; myocarditis; patient cache: cord-353717-jjd90fyh.txt plain text: cord-353717-jjd90fyh.txt item: #116 of 116 id: cord-355560-vsxe97xs author: Alves, Amanda Mandarino title: SARS-CoV-2 leading to Acute Pancreatitis: an unusual presentation date: 2020-09-15 words: 1661 flesch: 38 summary: There are few articles reporting pancreatic injury in COVID-19 patients but most of them do not report acute pancreatitis. [16] and may alter disease prognosis, since diabetes and ambient hyperglycemia were independent predictors for death and morbidity in SARS patients [16, 17] . keywords: acute; cov-2; pancreatitis; patients; sars cache: cord-355560-vsxe97xs.txt plain text: cord-355560-vsxe97xs.txt