id	sid	tid	token	lemma	pos
cord-018764-02l423mk	1	1	key	key	ADJ
cord-018764-02l423mk	1	2	:	:	PUNCT
cord-018764-02l423mk	1	3	cord-018764	cord-018764	NOUN
cord-018764-02l423mk	1	4	-	-	PUNCT
cord-018764-02l423mk	1	5	02l423mk	02l423mk	NUM
cord-018764-02l423mk	1	6	authors	author	NOUN
cord-018764-02l423mk	1	7	:	:	PUNCT
cord-018764-02l423mk	1	8	clark	clark	PROPN
cord-018764-02l423mk	1	9	,	,	PUNCT
cord-018764-02l423mk	1	10	ian	ian	PROPN
cord-018764-02l423mk	1	11	a.	a.	PROPN
cord-018764-02l423mk	1	12	;	;	PUNCT
cord-018764-02l423mk	1	13	griffiths	griffiths	PROPN
cord-018764-02l423mk	1	14	,	,	PUNCT
cord-018764-02l423mk	1	15	michael	michael	PROPN
cord-018764-02l423mk	1	16	j.	j.	PROPN
cord-018764-02l423mk	1	17	title	title	PROPN
cord-018764-02l423mk	1	18	:	:	PUNCT
cord-018764-02l423mk	1	19	the	the	DET
cord-018764-02l423mk	1	20	molecular	molecular	ADJ
cord-018764-02l423mk	1	21	basis	basis	NOUN
cord-018764-02l423mk	1	22	of	of	ADP
cord-018764-02l423mk	1	23	paediatric	paediatric	ADJ
cord-018764-02l423mk	1	24	malarial	malarial	ADJ
cord-018764-02l423mk	1	25	disease	disease	NOUN
cord-018764-02l423mk	1	26	date	date	NOUN
cord-018764-02l423mk	1	27	:	:	PUNCT
cord-018764-02l423mk	1	28	2007	2007	NUM
cord-018764-02l423mk	1	29	journal	journal	NOUN
cord-018764-02l423mk	1	30	:	:	PUNCT
cord-018764-02l423mk	1	31	pediatric	pediatric	ADJ
cord-018764-02l423mk	1	32	infectious	infectious	ADJ
cord-018764-02l423mk	1	33	diseases	disease	NOUN
cord-018764-02l423mk	1	34	revisited	revisit	VERB
cord-018764-02l423mk	1	35	doi	doi	PROPN
cord-018764-02l423mk	1	36	:	:	PUNCT
cord-018764-02l423mk	1	37	10.1007/978	10.1007/978	NUM
cord-018764-02l423mk	1	38	-	-	SYM
cord-018764-02l423mk	1	39	3	3	NUM
cord-018764-02l423mk	1	40	-	-	NUM
cord-018764-02l423mk	1	41	7643	7643	NUM
cord-018764-02l423mk	1	42	-	-	SYM
cord-018764-02l423mk	1	43	8099	8099	NUM
cord-018764-02l423mk	1	44	-	-	SYM
cord-018764-02l423mk	1	45	1_9	1_9	NOUN
cord-018764-02l423mk	1	46	sha	shall	AUX
cord-018764-02l423mk	1	47	:	:	PUNCT
cord-018764-02l423mk	1	48	doc_id	doc_id	X
cord-018764-02l423mk	1	49	:	:	PUNCT
cord-018764-02l423mk	1	50	18764	18764	NUM
cord-018764-02l423mk	1	51	cord_uid	cord_uid	PROPN
cord-018764-02l423mk	1	52	:	:	PUNCT
cord-018764-02l423mk	1	53	02l423mk	02l423mk	X
cord-018764-02l423mk	1	54	severe	severe	ADJ
cord-018764-02l423mk	1	55	falciparum	falciparum	NOUN
cord-018764-02l423mk	1	56	malaria	malaria	NOUN
cord-018764-02l423mk	1	57	is	be	AUX
cord-018764-02l423mk	1	58	an	an	DET
cord-018764-02l423mk	1	59	acute	acute	ADJ
cord-018764-02l423mk	1	60	systemic	systemic	ADJ
cord-018764-02l423mk	1	61	disease	disease	NOUN
cord-018764-02l423mk	1	62	that	that	PRON
cord-018764-02l423mk	1	63	can	can	AUX
cord-018764-02l423mk	1	64	affect	affect	VERB
cord-018764-02l423mk	1	65	multiple	multiple	ADJ
cord-018764-02l423mk	1	66	organs	organ	NOUN
cord-018764-02l423mk	1	67	,	,	PUNCT
cord-018764-02l423mk	1	68	including	include	VERB
cord-018764-02l423mk	1	69	those	those	PRON
cord-018764-02l423mk	1	70	in	in	ADP
cord-018764-02l423mk	1	71	which	which	PRON
cord-018764-02l423mk	1	72	few	few	ADJ
cord-018764-02l423mk	1	73	parasites	parasite	NOUN
cord-018764-02l423mk	1	74	are	be	AUX
cord-018764-02l423mk	1	75	found	find	VERB
cord-018764-02l423mk	1	76	.	.	PUNCT
cord-018764-02l423mk	2	1	the	the	DET
cord-018764-02l423mk	2	2	acute	acute	ADJ
cord-018764-02l423mk	2	3	disease	disease	NOUN
cord-018764-02l423mk	2	4	bears	bear	VERB
cord-018764-02l423mk	2	5	many	many	ADJ
cord-018764-02l423mk	2	6	similarities	similarity	NOUN
cord-018764-02l423mk	2	7	both	both	CCONJ
cord-018764-02l423mk	2	8	clinically	clinically	ADV
cord-018764-02l423mk	2	9	and	and	CCONJ
cord-018764-02l423mk	2	10	,	,	PUNCT
cord-018764-02l423mk	2	11	potentially	potentially	ADV
cord-018764-02l423mk	2	12	,	,	PUNCT
cord-018764-02l423mk	2	13	mechanistically	mechanistically	PROPN
cord-018764-02l423mk	2	14	,	,	PUNCT
cord-018764-02l423mk	2	15	to	to	ADP
cord-018764-02l423mk	2	16	the	the	DET
cord-018764-02l423mk	2	17	systemic	systemic	ADJ
cord-018764-02l423mk	2	18	diseases	disease	NOUN
cord-018764-02l423mk	2	19	caused	cause	VERB
cord-018764-02l423mk	2	20	by	by	ADP
cord-018764-02l423mk	2	21	bacteria	bacteria	NOUN
cord-018764-02l423mk	2	22	,	,	PUNCT
cord-018764-02l423mk	2	23	rickettsia	rickettsia	PROPN
cord-018764-02l423mk	2	24	,	,	PUNCT
cord-018764-02l423mk	2	25	and	and	CCONJ
cord-018764-02l423mk	2	26	viruses	virus	NOUN
cord-018764-02l423mk	2	27	.	.	PUNCT
cord-018764-02l423mk	3	1	traditionally	traditionally	ADV
cord-018764-02l423mk	3	2	the	the	DET
cord-018764-02l423mk	3	3	morbidity	morbidity	NOUN
cord-018764-02l423mk	3	4	and	and	CCONJ
cord-018764-02l423mk	3	5	mortality	mortality	NOUN
cord-018764-02l423mk	3	6	associated	associate	VERB
cord-018764-02l423mk	3	7	with	with	ADP
cord-018764-02l423mk	3	8	severe	severe	ADJ
cord-018764-02l423mk	3	9	malarial	malarial	ADJ
cord-018764-02l423mk	3	10	disease	disease	NOUN
cord-018764-02l423mk	3	11	has	have	AUX
cord-018764-02l423mk	3	12	been	be	AUX
cord-018764-02l423mk	3	13	explained	explain	VERB
cord-018764-02l423mk	3	14	in	in	ADP
cord-018764-02l423mk	3	15	terms	term	NOUN
cord-018764-02l423mk	3	16	of	of	ADP
cord-018764-02l423mk	3	17	mechanical	mechanical	ADJ
cord-018764-02l423mk	3	18	obstruction	obstruction	NOUN
cord-018764-02l423mk	3	19	to	to	PART
cord-018764-02l423mk	3	20	vascular	vascular	VERB
cord-018764-02l423mk	3	21	flow	flow	NOUN
cord-018764-02l423mk	3	22	by	by	ADP
cord-018764-02l423mk	3	23	adherence	adherence	NOUN
cord-018764-02l423mk	3	24	to	to	ADP
cord-018764-02l423mk	3	25	endothelium	endothelium	PROPN
cord-018764-02l423mk	3	26	(	(	PUNCT
cord-018764-02l423mk	3	27	termed	term	VERB
cord-018764-02l423mk	3	28	sequestration	sequestration	NOUN
cord-018764-02l423mk	3	29	)	)	PUNCT
cord-018764-02l423mk	3	30	of	of	ADP
cord-018764-02l423mk	3	31	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	3	32	containing	contain	VERB
cord-018764-02l423mk	3	33	mature	mature	ADJ
cord-018764-02l423mk	3	34	-	-	PUNCT
cord-018764-02l423mk	3	35	stage	stage	NOUN
cord-018764-02l423mk	3	36	parasites	parasite	NOUN
cord-018764-02l423mk	3	37	.	.	PUNCT
cord-018764-02l423mk	4	1	however	however	ADV
cord-018764-02l423mk	4	2	,	,	PUNCT
cord-018764-02l423mk	4	3	over	over	ADP
cord-018764-02l423mk	4	4	the	the	DET
cord-018764-02l423mk	4	5	past	past	ADJ
cord-018764-02l423mk	4	6	few	few	ADJ
cord-018764-02l423mk	4	7	decades	decade	NOUN
cord-018764-02l423mk	4	8	an	an	DET
cord-018764-02l423mk	4	9	alternative	alternative	ADJ
cord-018764-02l423mk	4	10	‘	'	PUNCT
cord-018764-02l423mk	4	11	cytokine	cytokine	NOUN
cord-018764-02l423mk	4	12	theory	theory	NOUN
cord-018764-02l423mk	4	13	of	of	ADP
cord-018764-02l423mk	4	14	disease	disease	NOUN
cord-018764-02l423mk	4	15	’	'	PUNCT
cord-018764-02l423mk	4	16	has	have	AUX
cord-018764-02l423mk	4	17	also	also	ADV
cord-018764-02l423mk	4	18	evolved	evolve	VERB
cord-018764-02l423mk	4	19	,	,	PUNCT
cord-018764-02l423mk	4	20	where	where	SCONJ
cord-018764-02l423mk	4	21	malarial	malarial	ADJ
cord-018764-02l423mk	4	22	pathology	pathology	NOUN
cord-018764-02l423mk	4	23	is	be	AUX
cord-018764-02l423mk	4	24	explained	explain	VERB
cord-018764-02l423mk	4	25	in	in	ADP
cord-018764-02l423mk	4	26	terms	term	NOUN
cord-018764-02l423mk	4	27	of	of	ADP
cord-018764-02l423mk	4	28	a	a	DET
cord-018764-02l423mk	4	29	balance	balance	NOUN
cord-018764-02l423mk	4	30	between	between	ADP
cord-018764-02l423mk	4	31	the	the	DET
cord-018764-02l423mk	4	32	proand	proand	NOUN
cord-018764-02l423mk	4	33	anti	anti	ADJ
cord-018764-02l423mk	4	34	-	-	ADJ
cord-018764-02l423mk	4	35	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	4	36	cytokines	cytokine	NOUN
cord-018764-02l423mk	4	37	.	.	PUNCT
cord-018764-02l423mk	5	1	the	the	DET
cord-018764-02l423mk	5	2	final	final	ADJ
cord-018764-02l423mk	5	3	common	common	ADJ
cord-018764-02l423mk	5	4	pathway	pathway	NOUN
cord-018764-02l423mk	5	5	for	for	ADP
cord-018764-02l423mk	5	6	this	this	DET
cord-018764-02l423mk	5	7	pro	pro	ADJ
cord-018764-02l423mk	5	8	-	-	ADJ
cord-018764-02l423mk	5	9	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	5	10	imbalance	imbalance	NOUN
cord-018764-02l423mk	5	11	is	be	AUX
cord-018764-02l423mk	5	12	believed	believe	VERB
cord-018764-02l423mk	5	13	to	to	PART
cord-018764-02l423mk	5	14	be	be	AUX
cord-018764-02l423mk	5	15	a	a	DET
cord-018764-02l423mk	5	16	limitation	limitation	NOUN
cord-018764-02l423mk	5	17	in	in	ADP
cord-018764-02l423mk	5	18	the	the	DET
cord-018764-02l423mk	5	19	supply	supply	NOUN
cord-018764-02l423mk	5	20	and	and	CCONJ
cord-018764-02l423mk	5	21	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	5	22	utilisation	utilisation	NOUN
cord-018764-02l423mk	5	23	of	of	ADP
cord-018764-02l423mk	5	24	energy	energy	NOUN
cord-018764-02l423mk	5	25	to	to	ADP
cord-018764-02l423mk	5	26	cells	cell	NOUN
cord-018764-02l423mk	5	27	.	.	PUNCT
cord-018764-02l423mk	6	1	different	different	ADJ
cord-018764-02l423mk	6	2	patterns	pattern	NOUN
cord-018764-02l423mk	6	3	of	of	ADP
cord-018764-02l423mk	6	4	ensuing	ensue	VERB
cord-018764-02l423mk	6	5	energy	energy	NOUN
cord-018764-02l423mk	6	6	depletion	depletion	NOUN
cord-018764-02l423mk	6	7	(	(	PUNCT
cord-018764-02l423mk	6	8	both	both	PRON
cord-018764-02l423mk	6	9	temporal	temporal	ADJ
cord-018764-02l423mk	6	10	and	and	CCONJ
cord-018764-02l423mk	6	11	spatial	spatial	ADJ
cord-018764-02l423mk	6	12	)	)	PUNCT
cord-018764-02l423mk	6	13	throughout	throughout	ADP
cord-018764-02l423mk	6	14	the	the	DET
cord-018764-02l423mk	6	15	cells	cell	NOUN
cord-018764-02l423mk	6	16	in	in	ADP
cord-018764-02l423mk	6	17	the	the	DET
cord-018764-02l423mk	6	18	body	body	NOUN
cord-018764-02l423mk	6	19	present	present	ADJ
cord-018764-02l423mk	6	20	as	as	ADP
cord-018764-02l423mk	6	21	different	different	ADJ
cord-018764-02l423mk	6	22	clinical	clinical	ADJ
cord-018764-02l423mk	6	23	syndromes	syndrome	NOUN
cord-018764-02l423mk	6	24	.	.	PUNCT
cord-018764-02l423mk	7	1	this	this	DET
cord-018764-02l423mk	7	2	chapter	chapter	NOUN
cord-018764-02l423mk	7	3	draws	draw	VERB
cord-018764-02l423mk	7	4	attention	attention	NOUN
cord-018764-02l423mk	7	5	to	to	ADP
cord-018764-02l423mk	7	6	the	the	DET
cord-018764-02l423mk	7	7	over	over	ADV
cord-018764-02l423mk	7	8	-	-	PUNCT
cord-018764-02l423mk	7	9	arching	arch	VERB
cord-018764-02l423mk	7	10	position	position	NOUN
cord-018764-02l423mk	7	11	that	that	SCONJ
cord-018764-02l423mk	7	12	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	7	13	cytokines	cytokine	NOUN
cord-018764-02l423mk	7	14	are	be	AUX
cord-018764-02l423mk	7	15	beginning	begin	VERB
cord-018764-02l423mk	7	16	to	to	PART
cord-018764-02l423mk	7	17	occupy	occupy	VERB
cord-018764-02l423mk	7	18	in	in	ADP
cord-018764-02l423mk	7	19	the	the	DET
cord-018764-02l423mk	7	20	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	7	21	of	of	ADP
cord-018764-02l423mk	7	22	acute	acute	ADJ
cord-018764-02l423mk	7	23	malaria	malaria	NOUN
cord-018764-02l423mk	7	24	and	and	CCONJ
cord-018764-02l423mk	7	25	other	other	ADJ
cord-018764-02l423mk	7	26	acute	acute	ADJ
cord-018764-02l423mk	7	27	infections	infection	NOUN
cord-018764-02l423mk	7	28	.	.	PUNCT
cord-018764-02l423mk	8	1	the	the	DET
cord-018764-02l423mk	8	2	influence	influence	NOUN
cord-018764-02l423mk	8	3	of	of	ADP
cord-018764-02l423mk	8	4	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	8	5	cytokines	cytokine	NOUN
cord-018764-02l423mk	8	6	on	on	ADP
cord-018764-02l423mk	8	7	cellular	cellular	ADJ
cord-018764-02l423mk	8	8	function	function	NOUN
cord-018764-02l423mk	8	9	offers	offer	VERB
cord-018764-02l423mk	8	10	a	a	DET
cord-018764-02l423mk	8	11	molecular	molecular	ADJ
cord-018764-02l423mk	8	12	framework	framework	NOUN
cord-018764-02l423mk	8	13	to	to	PART
cord-018764-02l423mk	8	14	explain	explain	VERB
cord-018764-02l423mk	8	15	the	the	DET
cord-018764-02l423mk	8	16	multiple	multiple	ADJ
cord-018764-02l423mk	8	17	clinical	clinical	ADJ
cord-018764-02l423mk	8	18	syndromes	syndrome	NOUN
cord-018764-02l423mk	8	19	that	that	PRON
cord-018764-02l423mk	8	20	are	be	AUX
cord-018764-02l423mk	8	21	observed	observe	VERB
cord-018764-02l423mk	8	22	during	during	ADP
cord-018764-02l423mk	8	23	acute	acute	ADJ
cord-018764-02l423mk	8	24	malarial	malarial	ADJ
cord-018764-02l423mk	8	25	illness	illness	NOUN
cord-018764-02l423mk	8	26	,	,	PUNCT
cord-018764-02l423mk	8	27	and	and	CCONJ
cord-018764-02l423mk	8	28	provides	provide	VERB
cord-018764-02l423mk	8	29	a	a	DET
cord-018764-02l423mk	8	30	fresh	fresh	ADJ
cord-018764-02l423mk	8	31	avenue	avenue	NOUN
cord-018764-02l423mk	8	32	of	of	ADP
cord-018764-02l423mk	8	33	investigation	investigation	NOUN
cord-018764-02l423mk	8	34	for	for	ADP
cord-018764-02l423mk	8	35	adjunct	adjunct	ADJ
cord-018764-02l423mk	8	36	therapies	therapy	NOUN
cord-018764-02l423mk	8	37	to	to	PART
cord-018764-02l423mk	8	38	ameliorate	ameliorate	VERB
cord-018764-02l423mk	8	39	the	the	DET
cord-018764-02l423mk	8	40	malarial	malarial	ADJ
cord-018764-02l423mk	8	41	disease	disease	NOUN
cord-018764-02l423mk	8	42	process	process	NOUN
cord-018764-02l423mk	8	43	.	.	PUNCT
cord-018764-02l423mk	9	1	although	although	SCONJ
cord-018764-02l423mk	9	2	many	many	ADJ
cord-018764-02l423mk	9	3	species	specie	NOUN
cord-018764-02l423mk	9	4	of	of	ADP
cord-018764-02l423mk	9	5	malarial	malarial	ADJ
cord-018764-02l423mk	9	6	parasite	parasite	NOUN
cord-018764-02l423mk	9	7	exist	exist	VERB
cord-018764-02l423mk	9	8	,	,	PUNCT
cord-018764-02l423mk	9	9	only	only	ADV
cord-018764-02l423mk	9	10	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	9	11	falciparum	falciparum	NOUN
cord-018764-02l423mk	9	12	,	,	PUNCT
cord-018764-02l423mk	9	13	vivax	vivax	PROPN
cord-018764-02l423mk	9	14	,	,	PUNCT
cord-018764-02l423mk	9	15	ovale	ovale	NOUN
cord-018764-02l423mk	9	16	,	,	PUNCT
cord-018764-02l423mk	9	17	and	and	CCONJ
cord-018764-02l423mk	9	18	malariae	malariae	NOUN
cord-018764-02l423mk	9	19	are	be	AUX
cord-018764-02l423mk	9	20	classically	classically	ADV
cord-018764-02l423mk	9	21	associated	associate	VERB
cord-018764-02l423mk	9	22	with	with	ADP
cord-018764-02l423mk	9	23	human	human	ADJ
cord-018764-02l423mk	9	24	infection	infection	NOUN
cord-018764-02l423mk	9	25	.	.	PUNCT
cord-018764-02l423mk	10	1	the	the	DET
cord-018764-02l423mk	10	2	former	former	ADJ
cord-018764-02l423mk	10	3	two	two	NUM
cord-018764-02l423mk	10	4	species	specie	NOUN
cord-018764-02l423mk	10	5	are	be	AUX
cord-018764-02l423mk	10	6	most	most	ADV
cord-018764-02l423mk	10	7	frequently	frequently	ADV
cord-018764-02l423mk	10	8	associated	associate	VERB
cord-018764-02l423mk	10	9	with	with	ADP
cord-018764-02l423mk	10	10	malarial	malarial	ADJ
cord-018764-02l423mk	10	11	disease	disease	NOUN
cord-018764-02l423mk	10	12	in	in	ADP
cord-018764-02l423mk	10	13	humans	human	NOUN
cord-018764-02l423mk	10	14	,	,	PUNCT
cord-018764-02l423mk	10	15	with	with	ADP
cord-018764-02l423mk	10	16	severe	severe	ADJ
cord-018764-02l423mk	10	17	malarial	malarial	ADJ
cord-018764-02l423mk	10	18	disease	disease	NOUN
cord-018764-02l423mk	10	19	almost	almost	ADV
cord-018764-02l423mk	10	20	exclusively	exclusively	ADV
cord-018764-02l423mk	10	21	associated	associate	VERB
cord-018764-02l423mk	10	22	with	with	ADP
cord-018764-02l423mk	10	23	p.	p.	PROPN
cord-018764-02l423mk	10	24	falciparum	falciparum	NOUN
cord-018764-02l423mk	10	25	infection	infection	NOUN
cord-018764-02l423mk	10	26	.	.	PUNCT
cord-018764-02l423mk	11	1	falciparum	falciparum	NOUN
cord-018764-02l423mk	11	2	malaria	malaria	NOUN
cord-018764-02l423mk	11	3	is	be	AUX
cord-018764-02l423mk	11	4	responsible	responsible	ADJ
cord-018764-02l423mk	11	5	for	for	ADP
cord-018764-02l423mk	11	6	considerable	considerable	ADJ
cord-018764-02l423mk	11	7	morbidity	morbidity	NOUN
cord-018764-02l423mk	11	8	(	(	PUNCT
cord-018764-02l423mk	11	9	300	300	NUM
cord-018764-02l423mk	11	10	-	-	SYM
cord-018764-02l423mk	11	11	500	500	NUM
cord-018764-02l423mk	11	12	million	million	NUM
cord-018764-02l423mk	11	13	annual	annual	ADJ
cord-018764-02l423mk	11	14	clinical	clinical	ADJ
cord-018764-02l423mk	11	15	cases	case	NOUN
cord-018764-02l423mk	11	16	)	)	PUNCT
cord-018764-02l423mk	11	17	and	and	CCONJ
cord-018764-02l423mk	11	18	death	death	NOUN
cord-018764-02l423mk	11	19	across	across	ADP
cord-018764-02l423mk	11	20	the	the	DET
cord-018764-02l423mk	11	21	globe	globe	NOUN
cord-018764-02l423mk	11	22	,	,	PUNCT
cord-018764-02l423mk	11	23	with	with	ADP
cord-018764-02l423mk	11	24	a	a	DET
cord-018764-02l423mk	11	25	particular	particular	ADJ
cord-018764-02l423mk	11	26	burden	burden	NOUN
cord-018764-02l423mk	11	27	of	of	ADP
cord-018764-02l423mk	11	28	mortality	mortality	NOUN
cord-018764-02l423mk	11	29	among	among	ADP
cord-018764-02l423mk	11	30	children	child	NOUN
cord-018764-02l423mk	11	31	in	in	ADP
cord-018764-02l423mk	11	32	sub	sub	ADJ
cord-018764-02l423mk	11	33	-	-	ADJ
cord-018764-02l423mk	11	34	saharan	saharan	ADJ
cord-018764-02l423mk	11	35	africa	africa	PROPN
cord-018764-02l423mk	11	36	.	.	PUNCT
cord-018764-02l423mk	12	1	infection	infection	NOUN
cord-018764-02l423mk	12	2	with	with	ADP
cord-018764-02l423mk	12	3	p.	p.	PROPN
cord-018764-02l423mk	12	4	vivax	vivax	PROPN
cord-018764-02l423mk	12	5	is	be	AUX
cord-018764-02l423mk	12	6	rarely	rarely	ADV
cord-018764-02l423mk	12	7	fatal	fatal	ADJ
cord-018764-02l423mk	12	8	,	,	PUNCT
cord-018764-02l423mk	12	9	but	but	CCONJ
cord-018764-02l423mk	12	10	is	be	AUX
cord-018764-02l423mk	12	11	associated	associate	VERB
cord-018764-02l423mk	12	12	with	with	ADP
cord-018764-02l423mk	12	13	considerable	considerable	ADJ
cord-018764-02l423mk	12	14	morbidity	morbidity	NOUN
cord-018764-02l423mk	12	15	outside	outside	ADP
cord-018764-02l423mk	12	16	the	the	DET
cord-018764-02l423mk	12	17	african	african	ADJ
cord-018764-02l423mk	12	18	continent	continent	NOUN
cord-018764-02l423mk	12	19	.	.	PUNCT
cord-018764-02l423mk	13	1	it	it	PRON
cord-018764-02l423mk	13	2	should	should	AUX
cord-018764-02l423mk	13	3	also	also	ADV
cord-018764-02l423mk	13	4	be	be	AUX
cord-018764-02l423mk	13	5	recalled	recall	VERB
cord-018764-02l423mk	13	6	that	that	SCONJ
cord-018764-02l423mk	13	7	malaria	malaria	NOUN
cord-018764-02l423mk	13	8	causes	cause	VERB
cord-018764-02l423mk	13	9	social	social	ADJ
cord-018764-02l423mk	13	10	and	and	CCONJ
cord-018764-02l423mk	13	11	economic	economic	ADJ
cord-018764-02l423mk	13	12	disruption	disruption	NOUN
cord-018764-02l423mk	13	13	on	on	ADP
cord-018764-02l423mk	13	14	a	a	DET
cord-018764-02l423mk	13	15	uniquely	uniquely	ADV
cord-018764-02l423mk	13	16	large	large	ADJ
cord-018764-02l423mk	13	17	scale	scale	NOUN
cord-018764-02l423mk	13	18	[	[	NOUN
cord-018764-02l423mk	13	19	1	1	NUM
cord-018764-02l423mk	13	20	]	]	PUNCT
cord-018764-02l423mk	13	21	.	.	PUNCT
cord-018764-02l423mk	14	1	severe	severe	ADJ
cord-018764-02l423mk	14	2	adult	adult	NOUN
cord-018764-02l423mk	14	3	malaria	malaria	NOUN
cord-018764-02l423mk	14	4	is	be	AUX
cord-018764-02l423mk	14	5	a	a	DET
cord-018764-02l423mk	14	6	clinical	clinical	ADJ
cord-018764-02l423mk	14	7	syndrome	syndrome	NOUN
cord-018764-02l423mk	14	8	originally	originally	ADV
cord-018764-02l423mk	14	9	classified	classify	VERB
cord-018764-02l423mk	14	10	using	use	VERB
cord-018764-02l423mk	14	11	10	10	NUM
cord-018764-02l423mk	14	12	defining	define	VERB
cord-018764-02l423mk	14	13	and	and	CCONJ
cord-018764-02l423mk	14	14	5	5	NUM
cord-018764-02l423mk	14	15	supportive	supportive	ADJ
cord-018764-02l423mk	14	16	(	(	PUNCT
cord-018764-02l423mk	14	17	often	often	ADV
cord-018764-02l423mk	14	18	overlapping	overlap	VERB
cord-018764-02l423mk	14	19	)	)	PUNCT
cord-018764-02l423mk	14	20	clinical	clinical	ADJ
cord-018764-02l423mk	14	21	features	feature	NOUN
cord-018764-02l423mk	14	22	unified	unify	VERB
cord-018764-02l423mk	14	23	by	by	ADP
cord-018764-02l423mk	14	24	the	the	DET
cord-018764-02l423mk	14	25	presence	presence	NOUN
cord-018764-02l423mk	14	26	of	of	ADP
cord-018764-02l423mk	14	27	asexual	asexual	ADJ
cord-018764-02l423mk	14	28	malarial	malarial	ADJ
cord-018764-02l423mk	14	29	parasites	parasite	NOUN
cord-018764-02l423mk	14	30	in	in	ADP
cord-018764-02l423mk	14	31	the	the	DET
cord-018764-02l423mk	14	32	peripheral	peripheral	ADJ
cord-018764-02l423mk	14	33	blood	blood	NOUN
cord-018764-02l423mk	14	34	smear	smear	ADJ
cord-018764-02l423mk	14	35	[	[	X
cord-018764-02l423mk	14	36	2	2	NUM
cord-018764-02l423mk	14	37	]	]	PUNCT
cord-018764-02l423mk	14	38	.	.	PUNCT
cord-018764-02l423mk	15	1	based	base	VERB
cord-018764-02l423mk	15	2	on	on	ADP
cord-018764-02l423mk	15	3	observations	observation	NOUN
cord-018764-02l423mk	15	4	of	of	ADP
cord-018764-02l423mk	15	5	children	child	NOUN
cord-018764-02l423mk	15	6	in	in	ADP
cord-018764-02l423mk	15	7	coastal	coastal	PROPN
cord-018764-02l423mk	15	8	kenya	kenya	PROPN
cord-018764-02l423mk	15	9	,	,	PUNCT
cord-018764-02l423mk	15	10	paediatric	paediatric	ADJ
cord-018764-02l423mk	15	11	severe	severe	ADJ
cord-018764-02l423mk	15	12	malaria	malaria	NOUN
cord-018764-02l423mk	15	13	has	have	AUX
cord-018764-02l423mk	15	14	similarly	similarly	ADV
cord-018764-02l423mk	15	15	been	be	AUX
cord-018764-02l423mk	15	16	distilled	distil	VERB
cord-018764-02l423mk	15	17	into	into	ADP
cord-018764-02l423mk	15	18	three	three	NUM
cord-018764-02l423mk	15	19	main	main	ADJ
cord-018764-02l423mk	15	20	(	(	PUNCT
cord-018764-02l423mk	15	21	again	again	ADV
cord-018764-02l423mk	15	22	often	often	ADV
cord-018764-02l423mk	15	23	overlapping	overlap	VERB
cord-018764-02l423mk	15	24	)	)	PUNCT
cord-018764-02l423mk	15	25	clinical	clinical	ADJ
cord-018764-02l423mk	15	26	syndromes	syndrome	NOUN
cord-018764-02l423mk	15	27	,	,	PUNCT
cord-018764-02l423mk	15	28	anaemia	anaemia	NOUN
cord-018764-02l423mk	15	29	,	,	PUNCT
cord-018764-02l423mk	15	30	respiratory	respiratory	ADJ
cord-018764-02l423mk	15	31	distress	distress	NOUN
cord-018764-02l423mk	15	32	(	(	PUNCT
cord-018764-02l423mk	15	33	an	an	DET
cord-018764-02l423mk	15	34	indicator	indicator	NOUN
cord-018764-02l423mk	15	35	of	of	ADP
cord-018764-02l423mk	15	36	an	an	DET
cord-018764-02l423mk	15	37	underlying	underlying	ADJ
cord-018764-02l423mk	15	38	metabolic	metabolic	ADJ
cord-018764-02l423mk	15	39	acidosis	acidosis	NOUN
cord-018764-02l423mk	15	40	)	)	PUNCT
cord-018764-02l423mk	15	41	and	and	CCONJ
cord-018764-02l423mk	15	42	impairment	impairment	NOUN
cord-018764-02l423mk	15	43	of	of	ADP
cord-018764-02l423mk	15	44	consciousness	consciousness	NOUN
cord-018764-02l423mk	15	45	[	[	X
cord-018764-02l423mk	15	46	3	3	NUM
cord-018764-02l423mk	15	47	]	]	PUNCT
cord-018764-02l423mk	15	48	.	.	PUNCT
cord-018764-02l423mk	16	1	these	these	DET
cord-018764-02l423mk	16	2	clinical	clinical	ADJ
cord-018764-02l423mk	16	3	syndromes	syndrome	NOUN
cord-018764-02l423mk	16	4	are	be	AUX
cord-018764-02l423mk	16	5	discussed	discuss	VERB
cord-018764-02l423mk	16	6	below	below	ADP
cord-018764-02l423mk	16	7	.	.	PUNCT
cord-018764-02l423mk	17	1	in	in	ADP
cord-018764-02l423mk	17	2	the	the	DET
cord-018764-02l423mk	17	3	review	review	NOUN
cord-018764-02l423mk	17	4	mentioned	mention	VERB
cord-018764-02l423mk	17	5	above	above	ADP
cord-018764-02l423mk	17	6	[	[	X
cord-018764-02l423mk	17	7	3	3	NUM
cord-018764-02l423mk	17	8	]	]	PUNCT
cord-018764-02l423mk	17	9	,	,	PUNCT
cord-018764-02l423mk	17	10	the	the	DET
cord-018764-02l423mk	17	11	authors	author	NOUN
cord-018764-02l423mk	17	12	'	'	PART
cord-018764-02l423mk	17	13	judicious	judicious	ADJ
cord-018764-02l423mk	17	14	use	use	NOUN
cord-018764-02l423mk	17	15	of	of	ADP
cord-018764-02l423mk	17	16	the	the	DET
cord-018764-02l423mk	17	17	term	term	NOUN
cord-018764-02l423mk	17	18	impaired	impair	VERB
cord-018764-02l423mk	17	19	consciousness	consciousness	NOUN
cord-018764-02l423mk	17	20	,	,	PUNCT
cord-018764-02l423mk	17	21	rather	rather	ADV
cord-018764-02l423mk	17	22	than	than	ADP
cord-018764-02l423mk	17	23	cerebral	cerebral	ADJ
cord-018764-02l423mk	17	24	malaria	malaria	NOUN
cord-018764-02l423mk	17	25	(	(	PUNCT
cord-018764-02l423mk	17	26	cm	cm	PROPN
cord-018764-02l423mk	17	27	)	)	PUNCT
cord-018764-02l423mk	17	28	,	,	PUNCT
cord-018764-02l423mk	17	29	promoted	promote	VERB
cord-018764-02l423mk	17	30	the	the	DET
cord-018764-02l423mk	17	31	useful	useful	ADJ
cord-018764-02l423mk	17	32	concept	concept	NOUN
cord-018764-02l423mk	17	33	that	that	SCONJ
cord-018764-02l423mk	17	34	the	the	DET
cord-018764-02l423mk	17	35	neurological	neurological	ADJ
cord-018764-02l423mk	17	36	features	feature	NOUN
cord-018764-02l423mk	17	37	(	(	PUNCT
cord-018764-02l423mk	17	38	and	and	CCONJ
cord-018764-02l423mk	17	39	in	in	ADP
cord-018764-02l423mk	17	40	-	-	PUNCT
cord-018764-02l423mk	17	41	turn	turn	VERB
cord-018764-02l423mk	17	42	the	the	DET
cord-018764-02l423mk	17	43	underlying	underlie	VERB
cord-018764-02l423mk	17	44	mechanisms	mechanism	NOUN
cord-018764-02l423mk	17	45	)	)	PUNCT
cord-018764-02l423mk	17	46	associated	associate	VERB
cord-018764-02l423mk	17	47	with	with	ADP
cord-018764-02l423mk	17	48	severe	severe	ADJ
cord-018764-02l423mk	17	49	malaria	malaria	NOUN
cord-018764-02l423mk	17	50	are	be	AUX
cord-018764-02l423mk	17	51	not	not	PART
cord-018764-02l423mk	17	52	necessarily	necessarily	ADV
cord-018764-02l423mk	17	53	unique	unique	ADJ
cord-018764-02l423mk	17	54	to	to	ADP
cord-018764-02l423mk	17	55	malarial	malarial	ADJ
cord-018764-02l423mk	17	56	disease	disease	NOUN
cord-018764-02l423mk	17	57	.	.	PUNCT
cord-018764-02l423mk	18	1	indeed	indeed	ADV
cord-018764-02l423mk	18	2	,	,	PUNCT
cord-018764-02l423mk	18	3	over	over	ADP
cord-018764-02l423mk	18	4	60	60	NUM
cord-018764-02l423mk	18	5	years	year	NOUN
cord-018764-02l423mk	18	6	ago	ago	ADV
cord-018764-02l423mk	18	7	,	,	PUNCT
cord-018764-02l423mk	18	8	it	it	PRON
cord-018764-02l423mk	18	9	was	be	AUX
cord-018764-02l423mk	18	10	noted	note	VERB
cord-018764-02l423mk	18	11	that	that	SCONJ
cord-018764-02l423mk	18	12	the	the	DET
cord-018764-02l423mk	18	13	clinical	clinical	ADJ
cord-018764-02l423mk	18	14	features	feature	NOUN
cord-018764-02l423mk	18	15	of	of	ADP
cord-018764-02l423mk	18	16	malaria	malaria	NOUN
cord-018764-02l423mk	18	17	can	can	AUX
cord-018764-02l423mk	18	18	resemble	resemble	VERB
cord-018764-02l423mk	18	19	those	those	PRON
cord-018764-02l423mk	18	20	exhibited	exhibit	VERB
cord-018764-02l423mk	18	21	in	in	ADP
cord-018764-02l423mk	18	22	patients	patient	NOUN
cord-018764-02l423mk	18	23	with	with	ADP
cord-018764-02l423mk	18	24	fulminant	fulminant	ADJ
cord-018764-02l423mk	18	25	bacterial	bacterial	ADJ
cord-018764-02l423mk	18	26	or	or	CCONJ
cord-018764-02l423mk	18	27	viral	viral	ADJ
cord-018764-02l423mk	18	28	infections	infection	NOUN
cord-018764-02l423mk	18	29	[	[	PUNCT
cord-018764-02l423mk	18	30	4	4	NUM
cord-018764-02l423mk	18	31	]	]	PUNCT
cord-018764-02l423mk	18	32	.	.	PUNCT
cord-018764-02l423mk	19	1	severe	severe	ADJ
cord-018764-02l423mk	19	2	malaria	malaria	NOUN
cord-018764-02l423mk	19	3	has	have	AUX
cord-018764-02l423mk	19	4	been	be	AUX
cord-018764-02l423mk	19	5	intensively	intensively	ADV
cord-018764-02l423mk	19	6	studied	study	VERB
cord-018764-02l423mk	19	7	,	,	PUNCT
cord-018764-02l423mk	19	8	and	and	CCONJ
cord-018764-02l423mk	19	9	there	there	PRON
cord-018764-02l423mk	19	10	appears	appear	VERB
cord-018764-02l423mk	19	11	to	to	PART
cord-018764-02l423mk	19	12	be	be	AUX
cord-018764-02l423mk	19	13	a	a	DET
cord-018764-02l423mk	19	14	complex	complex	ADJ
cord-018764-02l423mk	19	15	interplay	interplay	NOUN
cord-018764-02l423mk	19	16	between	between	ADP
cord-018764-02l423mk	19	17	host	host	NOUN
cord-018764-02l423mk	19	18	infection	infection	NOUN
cord-018764-02l423mk	19	19	and	and	CCONJ
cord-018764-02l423mk	19	20	disease	disease	NOUN
cord-018764-02l423mk	19	21	.	.	PUNCT
cord-018764-02l423mk	20	1	this	this	PRON
cord-018764-02l423mk	20	2	is	be	AUX
cord-018764-02l423mk	20	3	highlighted	highlight	VERB
cord-018764-02l423mk	20	4	by	by	ADP
cord-018764-02l423mk	20	5	the	the	DET
cord-018764-02l423mk	20	6	different	different	ADJ
cord-018764-02l423mk	20	7	clinical	clinical	ADJ
cord-018764-02l423mk	20	8	manifestations	manifestation	NOUN
cord-018764-02l423mk	20	9	of	of	ADP
cord-018764-02l423mk	20	10	severe	severe	ADJ
cord-018764-02l423mk	20	11	malaria	malaria	NOUN
cord-018764-02l423mk	20	12	exhibited	exhibit	VERB
cord-018764-02l423mk	20	13	by	by	ADP
cord-018764-02l423mk	20	14	children	child	NOUN
cord-018764-02l423mk	20	15	and	and	CCONJ
cord-018764-02l423mk	20	16	adults	adult	NOUN
cord-018764-02l423mk	20	17	.	.	PUNCT
cord-018764-02l423mk	21	1	these	these	DET
cord-018764-02l423mk	21	2	differences	difference	NOUN
cord-018764-02l423mk	21	3	are	be	AUX
cord-018764-02l423mk	21	4	undoubtedly	undoubtedly	ADV
cord-018764-02l423mk	21	5	,	,	PUNCT
cord-018764-02l423mk	21	6	in	in	ADP
cord-018764-02l423mk	21	7	part	part	NOUN
cord-018764-02l423mk	21	8	,	,	PUNCT
cord-018764-02l423mk	21	9	a	a	DET
cord-018764-02l423mk	21	10	function	function	NOUN
cord-018764-02l423mk	21	11	of	of	ADP
cord-018764-02l423mk	21	12	patient	patient	ADJ
cord-018764-02l423mk	21	13	age	age	NOUN
cord-018764-02l423mk	21	14	.	.	PUNCT
cord-018764-02l423mk	22	1	however	however	ADV
cord-018764-02l423mk	22	2	,	,	PUNCT
cord-018764-02l423mk	22	3	age	age	NOUN
cord-018764-02l423mk	22	4	is	be	AUX
cord-018764-02l423mk	22	5	just	just	ADV
cord-018764-02l423mk	22	6	one	one	NUM
cord-018764-02l423mk	22	7	of	of	ADP
cord-018764-02l423mk	22	8	a	a	DET
cord-018764-02l423mk	22	9	series	series	NOUN
cord-018764-02l423mk	22	10	of	of	ADP
cord-018764-02l423mk	22	11	interacting	interact	VERB
cord-018764-02l423mk	22	12	factors	factor	NOUN
cord-018764-02l423mk	22	13	,	,	PUNCT
cord-018764-02l423mk	22	14	e.g.	e.g.	ADV
cord-018764-02l423mk	22	15	geographical	geographical	ADJ
cord-018764-02l423mk	22	16	region	region	NOUN
cord-018764-02l423mk	22	17	,	,	PUNCT
cord-018764-02l423mk	22	18	level	level	NOUN
cord-018764-02l423mk	22	19	of	of	ADP
cord-018764-02l423mk	22	20	malaria	malaria	NOUN
cord-018764-02l423mk	22	21	transmission	transmission	NOUN
cord-018764-02l423mk	22	22	,	,	PUNCT
cord-018764-02l423mk	22	23	degree	degree	NOUN
cord-018764-02l423mk	22	24	of	of	ADP
cord-018764-02l423mk	22	25	previous	previous	ADJ
cord-018764-02l423mk	22	26	malaria	malaria	NOUN
cord-018764-02l423mk	22	27	exposure	exposure	NOUN
cord-018764-02l423mk	22	28	,	,	PUNCT
cord-018764-02l423mk	22	29	length	length	NOUN
cord-018764-02l423mk	22	30	of	of	ADP
cord-018764-02l423mk	22	31	illness	illness	NOUN
cord-018764-02l423mk	22	32	prior	prior	ADV
cord-018764-02l423mk	22	33	to	to	ADP
cord-018764-02l423mk	22	34	treatment	treatment	NOUN
cord-018764-02l423mk	22	35	and	and	CCONJ
cord-018764-02l423mk	22	36	host	host	NOUN
cord-018764-02l423mk	22	37	immunity	immunity	NOUN
cord-018764-02l423mk	22	38	that	that	PRON
cord-018764-02l423mk	22	39	may	may	AUX
cord-018764-02l423mk	22	40	influence	influence	VERB
cord-018764-02l423mk	22	41	the	the	DET
cord-018764-02l423mk	22	42	clinical	clinical	ADJ
cord-018764-02l423mk	22	43	presentation	presentation	NOUN
cord-018764-02l423mk	22	44	of	of	ADP
cord-018764-02l423mk	22	45	severe	severe	ADJ
cord-018764-02l423mk	22	46	malaria	malaria	NOUN
cord-018764-02l423mk	22	47	.	.	PUNCT
cord-018764-02l423mk	23	1	this	this	DET
cord-018764-02l423mk	23	2	variation	variation	NOUN
cord-018764-02l423mk	23	3	in	in	ADP
cord-018764-02l423mk	23	4	clinical	clinical	ADJ
cord-018764-02l423mk	23	5	presentation	presentation	NOUN
cord-018764-02l423mk	23	6	has	have	AUX
cord-018764-02l423mk	23	7	been	be	AUX
cord-018764-02l423mk	23	8	mirrored	mirror	VERB
cord-018764-02l423mk	23	9	by	by	ADP
cord-018764-02l423mk	23	10	a	a	DET
cord-018764-02l423mk	23	11	similar	similar	ADJ
cord-018764-02l423mk	23	12	multitude	multitude	NOUN
cord-018764-02l423mk	23	13	of	of	ADP
cord-018764-02l423mk	23	14	proposals	proposal	NOUN
cord-018764-02l423mk	23	15	regarding	regard	VERB
cord-018764-02l423mk	23	16	the	the	DET
cord-018764-02l423mk	23	17	functional	functional	ADJ
cord-018764-02l423mk	23	18	mechanisms	mechanism	NOUN
cord-018764-02l423mk	23	19	underlying	underlie	VERB
cord-018764-02l423mk	23	20	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	23	21	of	of	ADP
cord-018764-02l423mk	23	22	severe	severe	ADJ
cord-018764-02l423mk	23	23	malaria	malaria	NOUN
cord-018764-02l423mk	23	24	.	.	PUNCT
cord-018764-02l423mk	24	1	one	one	NUM
cord-018764-02l423mk	24	2	concept	concept	NOUN
cord-018764-02l423mk	24	3	of	of	ADP
cord-018764-02l423mk	24	4	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	24	5	consistently	consistently	ADV
cord-018764-02l423mk	24	6	articulated	articulate	VERB
cord-018764-02l423mk	24	7	has	have	AUX
cord-018764-02l423mk	24	8	been	be	AUX
cord-018764-02l423mk	24	9	the	the	DET
cord-018764-02l423mk	24	10	'	'	PUNCT
cord-018764-02l423mk	24	11	mechanical	mechanical	ADJ
cord-018764-02l423mk	24	12	theory	theory	NOUN
cord-018764-02l423mk	24	13	'	'	PUNCT
cord-018764-02l423mk	24	14	.	.	PUNCT
cord-018764-02l423mk	25	1	historically	historically	ADV
cord-018764-02l423mk	25	2	,	,	PUNCT
cord-018764-02l423mk	25	3	this	this	DET
cord-018764-02l423mk	25	4	theory	theory	NOUN
cord-018764-02l423mk	25	5	was	be	AUX
cord-018764-02l423mk	25	6	developed	develop	VERB
cord-018764-02l423mk	25	7	from	from	ADP
cord-018764-02l423mk	25	8	two	two	NUM
cord-018764-02l423mk	25	9	fundamental	fundamental	ADJ
cord-018764-02l423mk	25	10	differences	difference	NOUN
cord-018764-02l423mk	25	11	between	between	ADP
cord-018764-02l423mk	25	12	p.	p.	PROPN
cord-018764-02l423mk	25	13	falciparum	falciparum	NOUN
cord-018764-02l423mk	25	14	and	and	CCONJ
cord-018764-02l423mk	25	15	p.	p.	PROPN
cord-018764-02l423mk	25	16	vivax	vivax	PROPN
cord-018764-02l423mk	25	17	infection	infection	NOUN
cord-018764-02l423mk	25	18	.	.	PUNCT
cord-018764-02l423mk	26	1	firstly	firstly	ADV
cord-018764-02l423mk	26	2	,	,	PUNCT
cord-018764-02l423mk	26	3	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	26	4	parasitised	parasitise	VERB
cord-018764-02l423mk	26	5	with	with	ADP
cord-018764-02l423mk	26	6	p.	p.	PROPN
cord-018764-02l423mk	26	7	vivax	vivax	PROPN
cord-018764-02l423mk	26	8	do	do	AUX
cord-018764-02l423mk	26	9	not	not	PART
cord-018764-02l423mk	26	10	sequester	sequester	VERB
cord-018764-02l423mk	26	11	.	.	PUNCT
cord-018764-02l423mk	27	1	secondly	secondly	ADV
cord-018764-02l423mk	27	2	,	,	PUNCT
cord-018764-02l423mk	27	3	death	death	NOUN
cord-018764-02l423mk	27	4	following	follow	VERB
cord-018764-02l423mk	27	5	p.	p.	PROPN
cord-018764-02l423mk	27	6	vivax	vivax	PROPN
cord-018764-02l423mk	27	7	infection	infection	NOUN
cord-018764-02l423mk	27	8	is	be	AUX
cord-018764-02l423mk	27	9	rare	rare	ADJ
cord-018764-02l423mk	27	10	.	.	PUNCT
cord-018764-02l423mk	28	1	consequently	consequently	ADV
cord-018764-02l423mk	28	2	,	,	PUNCT
cord-018764-02l423mk	28	3	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	28	4	is	be	AUX
cord-018764-02l423mk	28	5	believed	believe	VERB
cord-018764-02l423mk	28	6	to	to	PART
cord-018764-02l423mk	28	7	be	be	AUX
cord-018764-02l423mk	28	8	due	due	ADJ
cord-018764-02l423mk	28	9	to	to	ADP
cord-018764-02l423mk	28	10	obstruction	obstruction	NOUN
cord-018764-02l423mk	28	11	of	of	ADP
cord-018764-02l423mk	28	12	micro	micro	ADJ
cord-018764-02l423mk	28	13	-	-	ADJ
cord-018764-02l423mk	28	14	vascular	vascular	ADJ
cord-018764-02l423mk	28	15	flow	flow	NOUN
cord-018764-02l423mk	28	16	by	by	ADP
cord-018764-02l423mk	28	17	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	28	18	containing	contain	VERB
cord-018764-02l423mk	28	19	mature	mature	ADJ
cord-018764-02l423mk	28	20	-	-	PUNCT
cord-018764-02l423mk	28	21	stage	stage	NOUN
cord-018764-02l423mk	28	22	falciparum	falciparum	NOUN
cord-018764-02l423mk	28	23	parasites	parasite	NOUN
cord-018764-02l423mk	28	24	adhering	adhere	VERB
cord-018764-02l423mk	28	25	to	to	ADP
cord-018764-02l423mk	28	26	the	the	DET
cord-018764-02l423mk	28	27	endothelium	endothelium	NOUN
cord-018764-02l423mk	28	28	(	(	PUNCT
cord-018764-02l423mk	28	29	termed	term	VERB
cord-018764-02l423mk	28	30	sequestration	sequestration	NOUN
cord-018764-02l423mk	28	31	)	)	PUNCT
cord-018764-02l423mk	28	32	.	.	PUNCT
cord-018764-02l423mk	29	1	more	more	ADV
cord-018764-02l423mk	29	2	recently	recently	ADV
cord-018764-02l423mk	29	3	the	the	DET
cord-018764-02l423mk	29	4	'	'	PUNCT
cord-018764-02l423mk	29	5	cytokine	cytokine	NOUN
cord-018764-02l423mk	29	6	theory	theory	NOUN
cord-018764-02l423mk	29	7	of	of	ADP
cord-018764-02l423mk	29	8	disease	disease	NOUN
cord-018764-02l423mk	29	9	'	'	PUNCT
cord-018764-02l423mk	29	10	has	have	AUX
cord-018764-02l423mk	29	11	also	also	ADV
cord-018764-02l423mk	29	12	gained	gain	VERB
cord-018764-02l423mk	29	13	credence	credence	NOUN
cord-018764-02l423mk	29	14	.	.	PUNCT
cord-018764-02l423mk	30	1	this	this	DET
cord-018764-02l423mk	30	2	theory	theory	NOUN
cord-018764-02l423mk	30	3	can	can	AUX
cord-018764-02l423mk	30	4	be	be	AUX
cord-018764-02l423mk	30	5	applied	apply	VERB
cord-018764-02l423mk	30	6	to	to	ADP
cord-018764-02l423mk	30	7	disease	disease	NOUN
cord-018764-02l423mk	30	8	following	follow	VERB
cord-018764-02l423mk	30	9	both	both	CCONJ
cord-018764-02l423mk	30	10	falciparum	falciparum	NOUN
cord-018764-02l423mk	30	11	and	and	CCONJ
cord-018764-02l423mk	30	12	vivax	vivax	PROPN
cord-018764-02l423mk	30	13	infection	infection	NOUN
cord-018764-02l423mk	30	14	.	.	PUNCT
cord-018764-02l423mk	31	1	the	the	DET
cord-018764-02l423mk	31	2	lower	low	ADJ
cord-018764-02l423mk	31	3	mortality	mortality	NOUN
cord-018764-02l423mk	31	4	associated	associate	VERB
cord-018764-02l423mk	31	5	with	with	ADP
cord-018764-02l423mk	31	6	p.	p.	PROPN
cord-018764-02l423mk	31	7	vivax	vivax	PROPN
cord-018764-02l423mk	31	8	being	be	AUX
cord-018764-02l423mk	31	9	explained	explain	VERB
cord-018764-02l423mk	31	10	by	by	ADP
cord-018764-02l423mk	31	11	a	a	DET
cord-018764-02l423mk	31	12	relatively	relatively	ADV
cord-018764-02l423mk	31	13	milder	mild	ADJ
cord-018764-02l423mk	31	14	degree	degree	NOUN
cord-018764-02l423mk	31	15	of	of	ADP
cord-018764-02l423mk	31	16	pro	pro	ADJ
cord-018764-02l423mk	31	17	-	-	ADJ
cord-018764-02l423mk	31	18	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	31	19	imbalance	imbalance	NOUN
cord-018764-02l423mk	31	20	during	during	ADP
cord-018764-02l423mk	31	21	the	the	DET
cord-018764-02l423mk	31	22	host	host	NOUN
cord-018764-02l423mk	31	23	's	's	PART
cord-018764-02l423mk	31	24	response	response	NOUN
cord-018764-02l423mk	31	25	to	to	ADP
cord-018764-02l423mk	31	26	p.	p.	PROPN
cord-018764-02l423mk	31	27	vivax	vivax	PROPN
cord-018764-02l423mk	31	28	infection	infection	NOUN
cord-018764-02l423mk	31	29	.	.	PUNCT
cord-018764-02l423mk	32	1	the	the	DET
cord-018764-02l423mk	32	2	main	main	ADJ
cord-018764-02l423mk	32	3	theme	theme	NOUN
cord-018764-02l423mk	32	4	of	of	ADP
cord-018764-02l423mk	32	5	this	this	DET
cord-018764-02l423mk	32	6	chapter	chapter	NOUN
cord-018764-02l423mk	32	7	is	be	AUX
cord-018764-02l423mk	32	8	to	to	PART
cord-018764-02l423mk	32	9	examine	examine	VERB
cord-018764-02l423mk	32	10	the	the	DET
cord-018764-02l423mk	32	11	increased	increase	VERB
cord-018764-02l423mk	32	12	understanding	understanding	NOUN
cord-018764-02l423mk	32	13	of	of	ADP
cord-018764-02l423mk	32	14	the	the	DET
cord-018764-02l423mk	32	15	functions	function	NOUN
cord-018764-02l423mk	32	16	of	of	ADP
cord-018764-02l423mk	32	17	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	32	18	cytokines	cytokine	NOUN
cord-018764-02l423mk	32	19	gained	gain	VERB
cord-018764-02l423mk	32	20	over	over	ADP
cord-018764-02l423mk	32	21	the	the	DET
cord-018764-02l423mk	32	22	past	past	ADJ
cord-018764-02l423mk	32	23	15	15	NUM
cord-018764-02l423mk	32	24	years	year	NOUN
cord-018764-02l423mk	32	25	,	,	PUNCT
cord-018764-02l423mk	32	26	and	and	CCONJ
cord-018764-02l423mk	32	27	explore	explore	VERB
cord-018764-02l423mk	32	28	how	how	SCONJ
cord-018764-02l423mk	32	29	these	these	DET
cord-018764-02l423mk	32	30	insights	insight	NOUN
cord-018764-02l423mk	32	31	are	be	AUX
cord-018764-02l423mk	32	32	changing	change	VERB
cord-018764-02l423mk	32	33	attitudes	attitude	NOUN
cord-018764-02l423mk	32	34	in	in	ADP
cord-018764-02l423mk	32	35	malarial	malarial	ADJ
cord-018764-02l423mk	32	36	disease	disease	NOUN
cord-018764-02l423mk	32	37	research	research	NOUN
cord-018764-02l423mk	32	38	.	.	PUNCT
cord-018764-02l423mk	33	1	we	we	PRON
cord-018764-02l423mk	33	2	also	also	ADV
cord-018764-02l423mk	33	3	discuss	discuss	VERB
cord-018764-02l423mk	33	4	how	how	SCONJ
cord-018764-02l423mk	33	5	two	two	NUM
cord-018764-02l423mk	33	6	theories	theory	NOUN
cord-018764-02l423mk	33	7	(	(	PUNCT
cord-018764-02l423mk	33	8	mechanical	mechanical	ADJ
cord-018764-02l423mk	33	9	and	and	CCONJ
cord-018764-02l423mk	33	10	cytokine	cytokine	NOUN
cord-018764-02l423mk	33	11	)	)	PUNCT
cord-018764-02l423mk	33	12	can	can	AUX
cord-018764-02l423mk	33	13	,	,	PUNCT
cord-018764-02l423mk	33	14	as	as	SCONJ
cord-018764-02l423mk	33	15	proposed	propose	VERB
cord-018764-02l423mk	33	16	first	first	ADV
cord-018764-02l423mk	33	17	in	in	ADP
cord-018764-02l423mk	33	18	a	a	DET
cord-018764-02l423mk	33	19	recognisable	recognisable	ADJ
cord-018764-02l423mk	33	20	form	form	NOUN
cord-018764-02l423mk	33	21	at	at	ADV
cord-018764-02l423mk	33	22	least	least	ADJ
cord-018764-02l423mk	33	23	65	65	NUM
cord-018764-02l423mk	33	24	years	year	NOUN
cord-018764-02l423mk	33	25	ago	ago	ADV
cord-018764-02l423mk	33	26	[	[	X
cord-018764-02l423mk	33	27	5	5	NUM
cord-018764-02l423mk	33	28	]	]	PUNCT
cord-018764-02l423mk	33	29	,	,	PUNCT
cord-018764-02l423mk	33	30	be	be	AUX
cord-018764-02l423mk	33	31	complementary	complementary	ADJ
cord-018764-02l423mk	33	32	.	.	PUNCT
cord-018764-02l423mk	34	1	the	the	DET
cord-018764-02l423mk	34	2	majority	majority	NOUN
cord-018764-02l423mk	34	3	of	of	ADP
cord-018764-02l423mk	34	4	the	the	DET
cord-018764-02l423mk	34	5	clinical	clinical	ADJ
cord-018764-02l423mk	34	6	cases	case	NOUN
cord-018764-02l423mk	34	7	of	of	ADP
cord-018764-02l423mk	34	8	malaria	malaria	NOUN
cord-018764-02l423mk	34	9	occur	occur	VERB
cord-018764-02l423mk	34	10	in	in	ADP
cord-018764-02l423mk	34	11	sub	sub	ADJ
cord-018764-02l423mk	34	12	-	-	ADJ
cord-018764-02l423mk	34	13	saharan	saharan	ADJ
cord-018764-02l423mk	34	14	africa	africa	PROPN
cord-018764-02l423mk	34	15	.	.	PUNCT
cord-018764-02l423mk	35	1	nevertheless	nevertheless	ADV
cord-018764-02l423mk	35	2	,	,	PUNCT
cord-018764-02l423mk	35	3	malaria	malaria	NOUN
cord-018764-02l423mk	35	4	also	also	ADV
cord-018764-02l423mk	35	5	accounts	account	VERB
cord-018764-02l423mk	35	6	for	for	ADP
cord-018764-02l423mk	35	7	considerable	considerable	ADJ
cord-018764-02l423mk	35	8	morbidity	morbidity	NOUN
cord-018764-02l423mk	35	9	and	and	CCONJ
cord-018764-02l423mk	35	10	mortality	mortality	NOUN
cord-018764-02l423mk	35	11	in	in	ADP
cord-018764-02l423mk	35	12	other	other	ADJ
cord-018764-02l423mk	35	13	continents	continent	NOUN
cord-018764-02l423mk	35	14	particularly	particularly	ADV
cord-018764-02l423mk	35	15	south	south	PROPN
cord-018764-02l423mk	35	16	east	east	PROPN
cord-018764-02l423mk	35	17	asia	asia	PROPN
cord-018764-02l423mk	36	1	[	[	X
cord-018764-02l423mk	36	2	6	6	NUM
cord-018764-02l423mk	36	3	]	]	PUNCT
cord-018764-02l423mk	36	4	.	.	PUNCT
cord-018764-02l423mk	37	1	in	in	ADP
cord-018764-02l423mk	37	2	malaria	malaria	NOUN
cord-018764-02l423mk	37	3	-	-	PUNCT
cord-018764-02l423mk	37	4	endemic	endemic	ADJ
cord-018764-02l423mk	37	5	regions	region	NOUN
cord-018764-02l423mk	37	6	(	(	PUNCT
cord-018764-02l423mk	37	7	e.g.	e.g.	ADV
cord-018764-02l423mk	37	8	sub	sub	ADJ
cord-018764-02l423mk	37	9	-	-	ADJ
cord-018764-02l423mk	37	10	saharan	saharan	ADJ
cord-018764-02l423mk	37	11	africa	africa	PROPN
cord-018764-02l423mk	37	12	)	)	PUNCT
cord-018764-02l423mk	37	13	,	,	PUNCT
cord-018764-02l423mk	37	14	where	where	SCONJ
cord-018764-02l423mk	37	15	the	the	DET
cord-018764-02l423mk	37	16	resident	resident	ADJ
cord-018764-02l423mk	37	17	population	population	NOUN
cord-018764-02l423mk	37	18	have	have	VERB
cord-018764-02l423mk	37	19	continuous	continuous	ADJ
cord-018764-02l423mk	37	20	exposure	exposure	NOUN
cord-018764-02l423mk	37	21	to	to	ADP
cord-018764-02l423mk	37	22	malarial	malarial	ADJ
cord-018764-02l423mk	37	23	parasites	parasite	NOUN
cord-018764-02l423mk	37	24	,	,	PUNCT
cord-018764-02l423mk	37	25	most	most	ADJ
cord-018764-02l423mk	37	26	of	of	ADP
cord-018764-02l423mk	37	27	the	the	DET
cord-018764-02l423mk	37	28	severe	severe	ADJ
cord-018764-02l423mk	37	29	cases	case	NOUN
cord-018764-02l423mk	37	30	are	be	AUX
cord-018764-02l423mk	37	31	seen	see	VERB
cord-018764-02l423mk	37	32	in	in	ADP
cord-018764-02l423mk	37	33	children	child	NOUN
cord-018764-02l423mk	37	34	[	[	PUNCT
cord-018764-02l423mk	37	35	7	7	NUM
cord-018764-02l423mk	37	36	]	]	PUNCT
cord-018764-02l423mk	37	37	.	.	PUNCT
cord-018764-02l423mk	38	1	in	in	ADP
cord-018764-02l423mk	38	2	hypoendemic	hypoendemic	ADJ
cord-018764-02l423mk	38	3	regions	region	NOUN
cord-018764-02l423mk	38	4	(	(	PUNCT
cord-018764-02l423mk	38	5	e.g.	e.g.	ADV
cord-018764-02l423mk	38	6	south	south	PROPN
cord-018764-02l423mk	38	7	east	east	PROPN
cord-018764-02l423mk	38	8	asia	asia	PROPN
cord-018764-02l423mk	38	9	)	)	PUNCT
cord-018764-02l423mk	38	10	,	,	PUNCT
cord-018764-02l423mk	38	11	where	where	SCONJ
cord-018764-02l423mk	38	12	parasite	parasite	ADJ
cord-018764-02l423mk	38	13	exposure	exposure	NOUN
cord-018764-02l423mk	38	14	is	be	AUX
cord-018764-02l423mk	38	15	more	more	ADV
cord-018764-02l423mk	38	16	intermittent	intermittent	ADJ
cord-018764-02l423mk	38	17	,	,	PUNCT
cord-018764-02l423mk	38	18	cases	case	NOUN
cord-018764-02l423mk	38	19	of	of	ADP
cord-018764-02l423mk	38	20	severe	severe	ADJ
cord-018764-02l423mk	38	21	malaria	malaria	NOUN
cord-018764-02l423mk	38	22	are	be	AUX
cord-018764-02l423mk	38	23	also	also	ADV
cord-018764-02l423mk	38	24	common	common	ADJ
cord-018764-02l423mk	38	25	in	in	ADP
cord-018764-02l423mk	38	26	adults	adult	NOUN
cord-018764-02l423mk	38	27	(	(	PUNCT
cord-018764-02l423mk	38	28	tab	tab	NOUN
cord-018764-02l423mk	38	29	.	.	PROPN
cord-018764-02l423mk	38	30	1	1	NUM
cord-018764-02l423mk	38	31	)	)	PUNCT
cord-018764-02l423mk	38	32	.	.	PUNCT
cord-018764-02l423mk	39	1	clinical	clinical	ADJ
cord-018764-02l423mk	39	2	features	feature	NOUN
cord-018764-02l423mk	39	3	associated	associate	VERB
cord-018764-02l423mk	39	4	with	with	ADP
cord-018764-02l423mk	39	5	malaria	malaria	NOUN
cord-018764-02l423mk	39	6	mortality	mortality	NOUN
cord-018764-02l423mk	39	7	vary	vary	VERB
cord-018764-02l423mk	39	8	between	between	ADP
cord-018764-02l423mk	39	9	children	child	NOUN
cord-018764-02l423mk	39	10	and	and	CCONJ
cord-018764-02l423mk	39	11	adults	adult	NOUN
cord-018764-02l423mk	39	12	,	,	PUNCT
cord-018764-02l423mk	39	13	but	but	CCONJ
cord-018764-02l423mk	39	14	acidosis	acidosis	NOUN
cord-018764-02l423mk	39	15	and	and	CCONJ
cord-018764-02l423mk	39	16	coma	coma	NOUN
cord-018764-02l423mk	39	17	are	be	AUX
cord-018764-02l423mk	39	18	associated	associate	VERB
cord-018764-02l423mk	39	19	with	with	ADP
cord-018764-02l423mk	39	20	malarial	malarial	ADJ
cord-018764-02l423mk	39	21	mortality	mortality	NOUN
cord-018764-02l423mk	39	22	in	in	ADP
cord-018764-02l423mk	39	23	both	both	DET
cord-018764-02l423mk	39	24	populations	population	NOUN
cord-018764-02l423mk	39	25	[	[	PUNCT
cord-018764-02l423mk	39	26	7	7	NUM
cord-018764-02l423mk	39	27	,	,	PUNCT
cord-018764-02l423mk	39	28	8	8	NUM
cord-018764-02l423mk	39	29	]	]	PUNCT
cord-018764-02l423mk	39	30	.	.	PUNCT
cord-018764-02l423mk	40	1	acute	acute	ADJ
cord-018764-02l423mk	40	2	renal	renal	ADJ
cord-018764-02l423mk	40	3	failure	failure	NOUN
cord-018764-02l423mk	40	4	(	(	PUNCT
cord-018764-02l423mk	40	5	arf	arf	NOUN
cord-018764-02l423mk	40	6	)	)	PUNCT
cord-018764-02l423mk	40	7	and	and	CCONJ
cord-018764-02l423mk	40	8	pulmonary	pulmonary	ADJ
cord-018764-02l423mk	40	9	oedema	oedema	PROPN
cord-018764-02l423mk	40	10	,	,	PUNCT
cord-018764-02l423mk	40	11	a	a	DET
cord-018764-02l423mk	40	12	marker	marker	NOUN
cord-018764-02l423mk	40	13	for	for	ADP
cord-018764-02l423mk	40	14	adult	adult	NOUN
cord-018764-02l423mk	40	15	respiratory	respiratory	ADJ
cord-018764-02l423mk	40	16	distress	distress	NOUN
cord-018764-02l423mk	40	17	syndrome	syndrome	NOUN
cord-018764-02l423mk	40	18	(	(	PUNCT
cord-018764-02l423mk	40	19	ards	ard	NOUN
cord-018764-02l423mk	40	20	)	)	PUNCT
cord-018764-02l423mk	40	21	,	,	PUNCT
cord-018764-02l423mk	40	22	are	be	AUX
cord-018764-02l423mk	40	23	almost	almost	ADV
cord-018764-02l423mk	40	24	exclusively	exclusively	ADV
cord-018764-02l423mk	40	25	reported	report	VERB
cord-018764-02l423mk	40	26	among	among	ADP
cord-018764-02l423mk	40	27	adults	adult	NOUN
cord-018764-02l423mk	40	28	[	[	PUNCT
cord-018764-02l423mk	40	29	9	9	NUM
cord-018764-02l423mk	40	30	,	,	PUNCT
cord-018764-02l423mk	40	31	10	10	NUM
cord-018764-02l423mk	40	32	]	]	PUNCT
cord-018764-02l423mk	40	33	,	,	PUNCT
cord-018764-02l423mk	40	34	whereas	whereas	SCONJ
cord-018764-02l423mk	40	35	mortality	mortality	NOUN
cord-018764-02l423mk	40	36	associated	associate	VERB
cord-018764-02l423mk	40	37	with	with	ADP
cord-018764-02l423mk	40	38	hypoglycaemia	hypoglycaemia	NOUN
cord-018764-02l423mk	40	39	is	be	AUX
cord-018764-02l423mk	40	40	frequently	frequently	ADV
cord-018764-02l423mk	40	41	reported	report	VERB
cord-018764-02l423mk	40	42	among	among	ADP
cord-018764-02l423mk	40	43	children	child	NOUN
cord-018764-02l423mk	40	44	[	[	PUNCT
cord-018764-02l423mk	40	45	11	11	NUM
cord-018764-02l423mk	40	46	]	]	PUNCT
cord-018764-02l423mk	40	47	.	.	PUNCT
cord-018764-02l423mk	41	1	why	why	SCONJ
cord-018764-02l423mk	41	2	malarial	malarial	ADJ
cord-018764-02l423mk	41	3	disease	disease	NOUN
cord-018764-02l423mk	41	4	displays	display	VERB
cord-018764-02l423mk	41	5	such	such	ADJ
cord-018764-02l423mk	41	6	age	age	NOUN
cord-018764-02l423mk	41	7	-	-	PUNCT
cord-018764-02l423mk	41	8	related	relate	VERB
cord-018764-02l423mk	41	9	differences	difference	NOUN
cord-018764-02l423mk	41	10	in	in	ADP
cord-018764-02l423mk	41	11	pathophysiology	pathophysiology	NOUN
cord-018764-02l423mk	41	12	is	be	AUX
cord-018764-02l423mk	41	13	unclear	unclear	ADJ
cord-018764-02l423mk	41	14	.	.	PUNCT
cord-018764-02l423mk	42	1	however	however	ADV
cord-018764-02l423mk	42	2	,	,	PUNCT
cord-018764-02l423mk	42	3	these	these	DET
cord-018764-02l423mk	42	4	differences	difference	NOUN
cord-018764-02l423mk	42	5	are	be	AUX
cord-018764-02l423mk	42	6	not	not	PART
cord-018764-02l423mk	42	7	exclusive	exclusive	ADJ
cord-018764-02l423mk	42	8	to	to	ADP
cord-018764-02l423mk	42	9	malaria	malaria	NOUN
cord-018764-02l423mk	42	10	.	.	PUNCT
cord-018764-02l423mk	43	1	ards	ard	NOUN
cord-018764-02l423mk	43	2	,	,	PUNCT
cord-018764-02l423mk	43	3	which	which	PRON
cord-018764-02l423mk	43	4	is	be	AUX
cord-018764-02l423mk	43	5	more	more	ADV
cord-018764-02l423mk	43	6	frequently	frequently	ADV
cord-018764-02l423mk	43	7	observed	observe	VERB
cord-018764-02l423mk	43	8	as	as	ADP
cord-018764-02l423mk	43	9	a	a	DET
cord-018764-02l423mk	43	10	complication	complication	NOUN
cord-018764-02l423mk	43	11	of	of	ADP
cord-018764-02l423mk	43	12	trauma	trauma	NOUN
cord-018764-02l423mk	43	13	in	in	ADP
cord-018764-02l423mk	43	14	adults	adult	NOUN
cord-018764-02l423mk	43	15	compared	compare	VERB
cord-018764-02l423mk	43	16	with	with	ADP
cord-018764-02l423mk	43	17	children	child	NOUN
cord-018764-02l423mk	43	18	[	[	X
cord-018764-02l423mk	43	19	12	12	NUM
cord-018764-02l423mk	43	20	]	]	PUNCT
cord-018764-02l423mk	43	21	,	,	PUNCT
cord-018764-02l423mk	43	22	is	be	AUX
cord-018764-02l423mk	43	23	believed	believe	VERB
cord-018764-02l423mk	43	24	to	to	PART
cord-018764-02l423mk	43	25	reflect	reflect	VERB
cord-018764-02l423mk	43	26	an	an	DET
cord-018764-02l423mk	43	27	exaggerated	exaggerated	ADJ
cord-018764-02l423mk	43	28	pro	pro	ADJ
cord-018764-02l423mk	43	29	-	-	ADJ
cord-018764-02l423mk	43	30	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	43	31	response	response	NOUN
cord-018764-02l423mk	43	32	within	within	ADP
cord-018764-02l423mk	43	33	the	the	DET
cord-018764-02l423mk	43	34	lung	lung	NOUN
cord-018764-02l423mk	43	35	[	[	PUNCT
cord-018764-02l423mk	43	36	9	9	NUM
cord-018764-02l423mk	43	37	]	]	PUNCT
cord-018764-02l423mk	43	38	.	.	PUNCT
cord-018764-02l423mk	44	1	a	a	DET
cord-018764-02l423mk	44	2	possible	possible	ADJ
cord-018764-02l423mk	44	3	lead	lead	NOUN
cord-018764-02l423mk	44	4	for	for	ADP
cord-018764-02l423mk	44	5	future	future	ADJ
cord-018764-02l423mk	44	6	studies	study	NOUN
cord-018764-02l423mk	44	7	on	on	ADP
cord-018764-02l423mk	44	8	these	these	DET
cord-018764-02l423mk	44	9	age	age	NOUN
cord-018764-02l423mk	44	10	-	-	PUNCT
cord-018764-02l423mk	44	11	related	relate	VERB
cord-018764-02l423mk	44	12	differences	difference	NOUN
cord-018764-02l423mk	44	13	in	in	ADP
cord-018764-02l423mk	44	14	malaria	malaria	NOUN
cord-018764-02l423mk	44	15	is	be	AUX
cord-018764-02l423mk	44	16	suggested	suggest	VERB
cord-018764-02l423mk	44	17	by	by	ADP
cord-018764-02l423mk	44	18	a	a	DET
cord-018764-02l423mk	44	19	report	report	NOUN
cord-018764-02l423mk	44	20	of	of	ADP
cord-018764-02l423mk	44	21	peritoneal	peritoneal	ADJ
cord-018764-02l423mk	44	22	macrophages	macrophage	NOUN
cord-018764-02l423mk	44	23	collected	collect	VERB
cord-018764-02l423mk	44	24	from	from	ADP
cord-018764-02l423mk	44	25	healthy	healthy	ADJ
cord-018764-02l423mk	44	26	adults	adult	NOUN
cord-018764-02l423mk	44	27	producing	produce	VERB
cord-018764-02l423mk	44	28	much	much	ADV
cord-018764-02l423mk	44	29	less	less	ADJ
cord-018764-02l423mk	44	30	interleukin	interleukin	NOUN
cord-018764-02l423mk	44	31	(	(	PUNCT
cord-018764-02l423mk	44	32	il)-10	il)-10	NOUN
cord-018764-02l423mk	44	33	(	(	PUNCT
cord-018764-02l423mk	44	34	an	an	DET
cord-018764-02l423mk	44	35	anti	anti	ADJ
cord-018764-02l423mk	44	36	-	-	ADJ
cord-018764-02l423mk	44	37	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	44	38	cytokine	cytokine	NOUN
cord-018764-02l423mk	44	39	)	)	PUNCT
cord-018764-02l423mk	44	40	,	,	PUNCT
cord-018764-02l423mk	44	41	but	but	CCONJ
cord-018764-02l423mk	44	42	the	the	DET
cord-018764-02l423mk	44	43	same	same	ADJ
cord-018764-02l423mk	44	44	levels	level	NOUN
cord-018764-02l423mk	44	45	of	of	ADP
cord-018764-02l423mk	44	46	pro	pro	ADJ
cord-018764-02l423mk	44	47	-	-	ADJ
cord-018764-02l423mk	44	48	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	44	49	cytokine	cytokine	NOUN
cord-018764-02l423mk	44	50	,	,	PUNCT
cord-018764-02l423mk	44	51	than	than	ADP
cord-018764-02l423mk	44	52	those	those	PRON
cord-018764-02l423mk	44	53	from	from	ADP
cord-018764-02l423mk	44	54	healthy	healthy	ADJ
cord-018764-02l423mk	44	55	children	child	NOUN
cord-018764-02l423mk	44	56	,	,	PUNCT
cord-018764-02l423mk	44	57	giving	give	VERB
cord-018764-02l423mk	44	58	adults	adult	NOUN
cord-018764-02l423mk	44	59	a	a	DET
cord-018764-02l423mk	44	60	much	much	ADV
cord-018764-02l423mk	44	61	higher	high	ADJ
cord-018764-02l423mk	44	62	pro	pro	ADJ
cord-018764-02l423mk	44	63	-	-	ADJ
cord-018764-02l423mk	44	64	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	44	65	status	status	NOUN
cord-018764-02l423mk	44	66	[	[	PUNCT
cord-018764-02l423mk	44	67	13	13	NUM
cord-018764-02l423mk	44	68	,	,	PUNCT
cord-018764-02l423mk	44	69	14	14	NUM
cord-018764-02l423mk	44	70	]	]	PUNCT
cord-018764-02l423mk	44	71	.	.	PUNCT
cord-018764-02l423mk	45	1	the	the	DET
cord-018764-02l423mk	45	2	mechanism	mechanism	NOUN
cord-018764-02l423mk	45	3	of	of	ADP
cord-018764-02l423mk	45	4	malarial	malarial	ADJ
cord-018764-02l423mk	45	5	arf	arf	PROPN
cord-018764-02l423mk	45	6	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	45	7	is	be	AUX
cord-018764-02l423mk	45	8	postulated	postulate	VERB
cord-018764-02l423mk	45	9	to	to	PART
cord-018764-02l423mk	45	10	be	be	AUX
cord-018764-02l423mk	45	11	multifactorial	multifactorial	ADJ
cord-018764-02l423mk	45	12	,	,	PUNCT
cord-018764-02l423mk	45	13	involving	involve	VERB
cord-018764-02l423mk	45	14	mechanical	mechanical	ADJ
cord-018764-02l423mk	45	15	,	,	PUNCT
cord-018764-02l423mk	45	16	haemodynamic	haemodynamic	ADJ
cord-018764-02l423mk	45	17	,	,	PUNCT
cord-018764-02l423mk	45	18	and	and	CCONJ
cord-018764-02l423mk	45	19	immunological	immunological	ADJ
cord-018764-02l423mk	45	20	factors	factor	NOUN
cord-018764-02l423mk	45	21	[	[	X
cord-018764-02l423mk	45	22	15	15	NUM
cord-018764-02l423mk	45	23	]	]	PUNCT
cord-018764-02l423mk	45	24	.	.	PUNCT
cord-018764-02l423mk	46	1	the	the	DET
cord-018764-02l423mk	46	2	observation	observation	NOUN
cord-018764-02l423mk	46	3	that	that	PRON
cord-018764-02l423mk	46	4	arf	arf	PROPN
cord-018764-02l423mk	46	5	is	be	AUX
cord-018764-02l423mk	46	6	more	more	ADV
cord-018764-02l423mk	46	7	frequently	frequently	ADV
cord-018764-02l423mk	46	8	observed	observe	VERB
cord-018764-02l423mk	46	9	as	as	ADP
cord-018764-02l423mk	46	10	a	a	DET
cord-018764-02l423mk	46	11	complication	complication	NOUN
cord-018764-02l423mk	46	12	of	of	ADP
cord-018764-02l423mk	46	13	trauma	trauma	NOUN
cord-018764-02l423mk	46	14	in	in	ADP
cord-018764-02l423mk	46	15	adults	adult	NOUN
cord-018764-02l423mk	46	16	than	than	ADP
cord-018764-02l423mk	46	17	children	child	NOUN
cord-018764-02l423mk	46	18	[	[	PUNCT
cord-018764-02l423mk	46	19	12	12	NUM
cord-018764-02l423mk	46	20	]	]	PUNCT
cord-018764-02l423mk	46	21	suggests	suggest	VERB
cord-018764-02l423mk	46	22	that	that	SCONJ
cord-018764-02l423mk	46	23	age	age	NOUN
cord-018764-02l423mk	46	24	-	-	PUNCT
cord-018764-02l423mk	46	25	related	relate	VERB
cord-018764-02l423mk	46	26	variations	variation	NOUN
cord-018764-02l423mk	46	27	in	in	ADP
cord-018764-02l423mk	46	28	cytokine	cytokine	NOUN
cord-018764-02l423mk	46	29	response	response	NOUN
cord-018764-02l423mk	46	30	may	may	AUX
cord-018764-02l423mk	46	31	again	again	ADV
cord-018764-02l423mk	46	32	influence	influence	VERB
cord-018764-02l423mk	46	33	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	46	34	.	.	PUNCT
cord-018764-02l423mk	47	1	hypoglycaemia	hypoglycaemia	NOUN
cord-018764-02l423mk	47	2	is	be	AUX
cord-018764-02l423mk	47	3	regarded	regard	VERB
cord-018764-02l423mk	47	4	as	as	ADP
cord-018764-02l423mk	47	5	a	a	DET
cord-018764-02l423mk	47	6	more	more	ADV
cord-018764-02l423mk	47	7	frequent	frequent	ADJ
cord-018764-02l423mk	47	8	complication	complication	NOUN
cord-018764-02l423mk	47	9	of	of	ADP
cord-018764-02l423mk	47	10	sepsis	sepsis	NOUN
cord-018764-02l423mk	47	11	in	in	ADP
cord-018764-02l423mk	47	12	paediatric	paediatric	ADJ
cord-018764-02l423mk	47	13	populations	population	NOUN
cord-018764-02l423mk	47	14	compared	compare	VERB
cord-018764-02l423mk	47	15	with	with	ADP
cord-018764-02l423mk	47	16	adults	adult	NOUN
cord-018764-02l423mk	47	17	[	[	PUNCT
cord-018764-02l423mk	47	18	16	16	NUM
cord-018764-02l423mk	47	19	]	]	PUNCT
cord-018764-02l423mk	47	20	.	.	PUNCT
cord-018764-02l423mk	48	1	hypoglycaemia	hypoglycaemia	NOUN
cord-018764-02l423mk	48	2	in	in	ADP
cord-018764-02l423mk	48	3	children	child	NOUN
cord-018764-02l423mk	48	4	may	may	AUX
cord-018764-02l423mk	48	5	,	,	PUNCT
cord-018764-02l423mk	48	6	in	in	ADP
cord-018764-02l423mk	48	7	part	part	NOUN
cord-018764-02l423mk	48	8	,	,	PUNCT
cord-018764-02l423mk	48	9	be	be	AUX
cord-018764-02l423mk	48	10	associated	associate	VERB
cord-018764-02l423mk	48	11	with	with	ADP
cord-018764-02l423mk	48	12	a	a	DET
cord-018764-02l423mk	48	13	higher	high	ADJ
cord-018764-02l423mk	48	14	basal	basal	ADJ
cord-018764-02l423mk	48	15	metabolic	metabolic	ADJ
cord-018764-02l423mk	48	16	rate	rate	NOUN
cord-018764-02l423mk	48	17	,	,	PUNCT
cord-018764-02l423mk	48	18	and	and	CCONJ
cord-018764-02l423mk	48	19	lower	low	ADJ
cord-018764-02l423mk	48	20	glycolytic	glycolytic	NOUN
cord-018764-02l423mk	48	21	[	[	X
cord-018764-02l423mk	48	22	17	17	NUM
cord-018764-02l423mk	48	23	]	]	PUNCT
cord-018764-02l423mk	48	24	and	and	CCONJ
cord-018764-02l423mk	48	25	gluconeogenic	gluconeogenic	ADJ
cord-018764-02l423mk	48	26	substrate	substrate	ADJ
cord-018764-02l423mk	48	27	reserves	reserve	NOUN
cord-018764-02l423mk	48	28	compared	compare	VERB
cord-018764-02l423mk	48	29	to	to	ADP
cord-018764-02l423mk	48	30	adults	adult	NOUN
cord-018764-02l423mk	48	31	[	[	X
cord-018764-02l423mk	48	32	18	18	NUM
cord-018764-02l423mk	48	33	]	]	PUNCT
cord-018764-02l423mk	48	34	.	.	PUNCT
cord-018764-02l423mk	49	1	however	however	ADV
cord-018764-02l423mk	49	2	,	,	PUNCT
cord-018764-02l423mk	49	3	these	these	DET
cord-018764-02l423mk	49	4	substrates	substrate	NOUN
cord-018764-02l423mk	49	5	are	be	AUX
cord-018764-02l423mk	49	6	not	not	PART
cord-018764-02l423mk	49	7	always	always	ADV
cord-018764-02l423mk	49	8	limiting	limit	VERB
cord-018764-02l423mk	49	9	during	during	ADP
cord-018764-02l423mk	49	10	acute	acute	ADJ
cord-018764-02l423mk	49	11	paediatric	paediatric	ADJ
cord-018764-02l423mk	49	12	malaria	malaria	NOUN
cord-018764-02l423mk	49	13	,	,	PUNCT
cord-018764-02l423mk	49	14	suggesting	suggest	VERB
cord-018764-02l423mk	49	15	functional	functional	ADJ
cord-018764-02l423mk	49	16	impairments	impairment	NOUN
cord-018764-02l423mk	49	17	of	of	ADP
cord-018764-02l423mk	49	18	glucose	glucose	NOUN
cord-018764-02l423mk	49	19	metabolism	metabolism	NOUN
cord-018764-02l423mk	49	20	may	may	AUX
cord-018764-02l423mk	49	21	also	also	ADV
cord-018764-02l423mk	49	22	occur	occur	VERB
cord-018764-02l423mk	49	23	[	[	X
cord-018764-02l423mk	49	24	19	19	NUM
cord-018764-02l423mk	49	25	]	]	PUNCT
cord-018764-02l423mk	49	26	.	.	PUNCT
cord-018764-02l423mk	50	1	such	such	ADJ
cord-018764-02l423mk	50	2	functional	functional	ADJ
cord-018764-02l423mk	50	3	impairments	impairment	NOUN
cord-018764-02l423mk	50	4	may	may	AUX
cord-018764-02l423mk	50	5	,	,	PUNCT
cord-018764-02l423mk	50	6	in	in	ADP
cord-018764-02l423mk	50	7	part	part	NOUN
cord-018764-02l423mk	50	8	,	,	PUNCT
cord-018764-02l423mk	50	9	be	be	AUX
cord-018764-02l423mk	50	10	influenced	influence	VERB
cord-018764-02l423mk	50	11	by	by	ADP
cord-018764-02l423mk	50	12	increases	increase	NOUN
cord-018764-02l423mk	50	13	in	in	ADP
cord-018764-02l423mk	50	14	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	50	15	cytokines	cytokine	NOUN
cord-018764-02l423mk	50	16	as	as	SCONJ
cord-018764-02l423mk	50	17	the	the	DET
cord-018764-02l423mk	50	18	infection	infection	NOUN
cord-018764-02l423mk	50	19	progresses	progress	VERB
cord-018764-02l423mk	50	20	.	.	PUNCT
cord-018764-02l423mk	51	1	once	once	SCONJ
cord-018764-02l423mk	51	2	the	the	DET
cord-018764-02l423mk	51	3	malarial	malarial	ADJ
cord-018764-02l423mk	51	4	parasite	parasite	NOUN
cord-018764-02l423mk	51	5	was	be	AUX
cord-018764-02l423mk	51	6	identified	identify	VERB
cord-018764-02l423mk	51	7	as	as	ADP
cord-018764-02l423mk	51	8	the	the	DET
cord-018764-02l423mk	51	9	cause	cause	NOUN
cord-018764-02l423mk	51	10	of	of	ADP
cord-018764-02l423mk	51	11	disease	disease	NOUN
cord-018764-02l423mk	51	12	,	,	PUNCT
cord-018764-02l423mk	51	13	it	it	PRON
cord-018764-02l423mk	51	14	quickly	quickly	ADV
cord-018764-02l423mk	51	15	became	become	VERB
cord-018764-02l423mk	51	16	apparent	apparent	ADJ
cord-018764-02l423mk	51	17	that	that	SCONJ
cord-018764-02l423mk	51	18	illness	illness	NOUN
cord-018764-02l423mk	51	19	and	and	CCONJ
cord-018764-02l423mk	51	20	death	death	NOUN
cord-018764-02l423mk	51	21	were	be	AUX
cord-018764-02l423mk	51	22	linked	link	VERB
cord-018764-02l423mk	51	23	with	with	ADP
cord-018764-02l423mk	51	24	parasite	parasite	ADJ
cord-018764-02l423mk	51	25	invasion	invasion	NOUN
cord-018764-02l423mk	51	26	into	into	ADP
cord-018764-02l423mk	51	27	bloodstream	bloodstream	NOUN
cord-018764-02l423mk	51	28	and	and	CCONJ
cord-018764-02l423mk	51	29	subsequent	subsequent	ADJ
cord-018764-02l423mk	51	30	parasite	parasite	ADJ
cord-018764-02l423mk	51	31	growth	growth	NOUN
cord-018764-02l423mk	51	32	within	within	ADP
cord-018764-02l423mk	51	33	(	(	PUNCT
cord-018764-02l423mk	51	34	and	and	CCONJ
cord-018764-02l423mk	51	35	release	release	VERB
cord-018764-02l423mk	51	36	from	from	ADP
cord-018764-02l423mk	51	37	)	)	PUNCT
cord-018764-02l423mk	51	38	the	the	DET
cord-018764-02l423mk	51	39	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	51	40	.	.	PUNCT
cord-018764-02l423mk	52	1	by	by	ADP
cord-018764-02l423mk	52	2	the	the	DET
cord-018764-02l423mk	52	3	start	start	NOUN
cord-018764-02l423mk	52	4	of	of	ADP
cord-018764-02l423mk	52	5	the	the	DET
cord-018764-02l423mk	52	6	20th	20th	ADJ
cord-018764-02l423mk	52	7	century	century	NOUN
cord-018764-02l423mk	52	8	,	,	PUNCT
cord-018764-02l423mk	52	9	two	two	NUM
cord-018764-02l423mk	52	10	major	major	ADJ
cord-018764-02l423mk	52	11	theories	theory	NOUN
cord-018764-02l423mk	52	12	,	,	PUNCT
cord-018764-02l423mk	52	13	capillary	capillary	ADJ
cord-018764-02l423mk	52	14	blockage	blockage	NOUN
cord-018764-02l423mk	52	15	and	and	CCONJ
cord-018764-02l423mk	52	16	toxicity	toxicity	NOUN
cord-018764-02l423mk	52	17	of	of	ADP
cord-018764-02l423mk	52	18	the	the	DET
cord-018764-02l423mk	52	19	parasites	parasite	NOUN
cord-018764-02l423mk	52	20	themselves	themselves	PRON
cord-018764-02l423mk	52	21	,	,	PUNCT
cord-018764-02l423mk	52	22	had	have	AUX
cord-018764-02l423mk	52	23	been	be	AUX
cord-018764-02l423mk	52	24	proposed	propose	VERB
cord-018764-02l423mk	52	25	to	to	PART
cord-018764-02l423mk	52	26	explain	explain	VERB
cord-018764-02l423mk	52	27	morbidity	morbidity	NOUN
cord-018764-02l423mk	52	28	and	and	CCONJ
cord-018764-02l423mk	52	29	mortality	mortality	NOUN
cord-018764-02l423mk	52	30	.	.	PUNCT
cord-018764-02l423mk	53	1	thus	thus	ADV
cord-018764-02l423mk	53	2	,	,	PUNCT
cord-018764-02l423mk	53	3	the	the	DET
cord-018764-02l423mk	53	4	study	study	NOUN
cord-018764-02l423mk	53	5	of	of	ADP
cord-018764-02l423mk	53	6	malarial	malarial	ADJ
cord-018764-02l423mk	53	7	disease	disease	NOUN
cord-018764-02l423mk	53	8	is	be	AUX
cord-018764-02l423mk	53	9	not	not	PART
cord-018764-02l423mk	53	10	a	a	DET
cord-018764-02l423mk	53	11	settled	settle	VERB
cord-018764-02l423mk	53	12	story	story	NOUN
cord-018764-02l423mk	53	13	requiring	require	VERB
cord-018764-02l423mk	53	14	regular	regular	ADJ
cord-018764-02l423mk	53	15	updates	update	NOUN
cord-018764-02l423mk	53	16	,	,	PUNCT
cord-018764-02l423mk	53	17	but	but	CCONJ
cord-018764-02l423mk	53	18	one	one	NUM
cord-018764-02l423mk	53	19	containing	contain	VERB
cord-018764-02l423mk	53	20	,	,	PUNCT
cord-018764-02l423mk	53	21	from	from	ADP
cord-018764-02l423mk	53	22	its	its	PRON
cord-018764-02l423mk	53	23	beginning	beginning	NOUN
cord-018764-02l423mk	53	24	,	,	PUNCT
cord-018764-02l423mk	53	25	an	an	DET
cord-018764-02l423mk	53	26	unresolved	unresolved	ADJ
cord-018764-02l423mk	53	27	tension	tension	NOUN
cord-018764-02l423mk	53	28	.	.	PUNCT
cord-018764-02l423mk	54	1	vascular	vascular	ADJ
cord-018764-02l423mk	54	2	occlusion	occlusion	NOUN
cord-018764-02l423mk	54	3	and	and	CCONJ
cord-018764-02l423mk	54	4	malarial	malarial	ADJ
cord-018764-02l423mk	54	5	toxin	toxin	NOUN
cord-018764-02l423mk	54	6	(	(	PUNCT
cord-018764-02l423mk	54	7	nowadays	nowadays	ADV
cord-018764-02l423mk	54	8	vascular	vascular	ADJ
cord-018764-02l423mk	54	9	occlusion	occlusion	NOUN
cord-018764-02l423mk	54	10	and	and	CCONJ
cord-018764-02l423mk	54	11	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	54	12	cytokines	cytokine	NOUN
cord-018764-02l423mk	54	13	)	)	PUNCT
cord-018764-02l423mk	54	14	have	have	AUX
cord-018764-02l423mk	54	15	been	be	AUX
cord-018764-02l423mk	54	16	alternative	alternative	ADJ
cord-018764-02l423mk	54	17	approaches	approach	NOUN
cord-018764-02l423mk	54	18	to	to	ADP
cord-018764-02l423mk	54	19	understanding	understand	VERB
cord-018764-02l423mk	54	20	malarial	malarial	ADJ
cord-018764-02l423mk	54	21	disease	disease	NOUN
cord-018764-02l423mk	54	22	as	as	ADP
cord-018764-02l423mk	54	23	a	a	DET
cord-018764-02l423mk	54	24	whole	whole	NOUN
cord-018764-02l423mk	54	25	,	,	PUNCT
cord-018764-02l423mk	54	26	as	as	ADV
cord-018764-02l423mk	54	27	well	well	ADV
cord-018764-02l423mk	54	28	as	as	ADP
cord-018764-02l423mk	54	29	the	the	DET
cord-018764-02l423mk	54	30	coma	coma	NOUN
cord-018764-02l423mk	54	31	,	,	PUNCT
cord-018764-02l423mk	54	32	for	for	ADP
cord-018764-02l423mk	54	33	over	over	ADP
cord-018764-02l423mk	54	34	a	a	DET
cord-018764-02l423mk	54	35	century	century	NOUN
cord-018764-02l423mk	54	36	,	,	PUNCT
cord-018764-02l423mk	54	37	and	and	CCONJ
cord-018764-02l423mk	54	38	the	the	DET
cord-018764-02l423mk	54	39	two	two	NUM
cord-018764-02l423mk	54	40	have	have	AUX
cord-018764-02l423mk	54	41	often	often	ADV
cord-018764-02l423mk	54	42	been	be	AUX
cord-018764-02l423mk	54	43	discussed	discuss	VERB
cord-018764-02l423mk	54	44	side	side	NOUN
cord-018764-02l423mk	54	45	by	by	ADP
cord-018764-02l423mk	54	46	side	side	NOUN
cord-018764-02l423mk	54	47	[	[	PUNCT
cord-018764-02l423mk	54	48	5	5	NUM
cord-018764-02l423mk	54	49	,	,	PUNCT
cord-018764-02l423mk	54	50	20	20	NUM
cord-018764-02l423mk	54	51	,	,	PUNCT
cord-018764-02l423mk	54	52	21	21	NUM
cord-018764-02l423mk	54	53	]	]	PUNCT
cord-018764-02l423mk	54	54	.	.	PUNCT
cord-018764-02l423mk	55	1	the	the	DET
cord-018764-02l423mk	55	2	presence	presence	NOUN
cord-018764-02l423mk	55	3	of	of	ADP
cord-018764-02l423mk	55	4	hyperlactataemia	hyperlactataemia	PROPN
cord-018764-02l423mk	55	5	,	,	PUNCT
cord-018764-02l423mk	55	6	hypoglycaemia	hypoglycaemia	NOUN
cord-018764-02l423mk	55	7	,	,	PUNCT
cord-018764-02l423mk	55	8	and	and	CCONJ
cord-018764-02l423mk	55	9	metabolic	metabolic	ADJ
cord-018764-02l423mk	55	10	acidosis	acidosis	NOUN
cord-018764-02l423mk	55	11	,	,	PUNCT
cord-018764-02l423mk	55	12	all	all	DET
cord-018764-02l423mk	55	13	three	three	NUM
cord-018764-02l423mk	55	14	consistent	consistent	ADJ
cord-018764-02l423mk	55	15	with	with	ADP
cord-018764-02l423mk	55	16	a	a	DET
cord-018764-02l423mk	55	17	patient	patient	NOUN
cord-018764-02l423mk	55	18	being	be	AUX
cord-018764-02l423mk	55	19	forced	force	VERB
cord-018764-02l423mk	55	20	to	to	PART
cord-018764-02l423mk	55	21	rely	rely	VERB
cord-018764-02l423mk	55	22	on	on	ADP
cord-018764-02l423mk	55	23	anaerobic	anaerobic	NOUN
cord-018764-02l423mk	55	24	glycolysis	glycolysis	NOUN
cord-018764-02l423mk	55	25	for	for	ADP
cord-018764-02l423mk	55	26	energy	energy	NOUN
cord-018764-02l423mk	55	27	production	production	NOUN
cord-018764-02l423mk	55	28	,	,	PUNCT
cord-018764-02l423mk	55	29	have	have	AUX
cord-018764-02l423mk	55	30	provided	provide	VERB
cord-018764-02l423mk	55	31	a	a	DET
cord-018764-02l423mk	55	32	consensus	consensus	NOUN
cord-018764-02l423mk	55	33	that	that	SCONJ
cord-018764-02l423mk	55	34	hypoxia	hypoxia	NOUN
cord-018764-02l423mk	55	35	is	be	AUX
cord-018764-02l423mk	55	36	central	central	ADJ
cord-018764-02l423mk	55	37	to	to	PART
cord-018764-02l423mk	55	38	disease	disease	VERB
cord-018764-02l423mk	55	39	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	55	40	in	in	ADP
cord-018764-02l423mk	55	41	falciparum	falciparum	PROPN
cord-018764-02l423mk	55	42	malaria	malaria	NOUN
cord-018764-02l423mk	55	43	.	.	PUNCT
cord-018764-02l423mk	56	1	as	as	SCONJ
cord-018764-02l423mk	56	2	sum	sum	NOUN
cord-018764-02l423mk	56	3	-	-	PUNCT
cord-018764-02l423mk	56	4	marised	marise	VERB
cord-018764-02l423mk	56	5	below	below	ADV
cord-018764-02l423mk	56	6	,	,	PUNCT
cord-018764-02l423mk	56	7	the	the	DET
cord-018764-02l423mk	56	8	modern	modern	ADJ
cord-018764-02l423mk	56	9	literature	literature	NOUN
cord-018764-02l423mk	56	10	offers	offer	VERB
cord-018764-02l423mk	56	11	two	two	NUM
cord-018764-02l423mk	56	12	main	main	ADJ
cord-018764-02l423mk	56	13	theories	theory	NOUN
cord-018764-02l423mk	56	14	for	for	ADP
cord-018764-02l423mk	56	15	cellular	cellular	ADJ
cord-018764-02l423mk	56	16	hypoxia	hypoxia	NOUN
cord-018764-02l423mk	56	17	during	during	ADP
cord-018764-02l423mk	56	18	infection	infection	NOUN
cord-018764-02l423mk	56	19	;	;	PUNCT
cord-018764-02l423mk	56	20	insufficient	insufficient	ADJ
cord-018764-02l423mk	56	21	oxygen	oxygen	NOUN
cord-018764-02l423mk	56	22	delivery	delivery	NOUN
cord-018764-02l423mk	56	23	to	to	ADP
cord-018764-02l423mk	56	24	cells	cell	NOUN
cord-018764-02l423mk	56	25	and	and	CCONJ
cord-018764-02l423mk	56	26	impaired	impaired	ADJ
cord-018764-02l423mk	56	27	oxygen	oxygen	NOUN
cord-018764-02l423mk	56	28	utilization	utilization	NOUN
cord-018764-02l423mk	56	29	within	within	ADP
cord-018764-02l423mk	56	30	the	the	DET
cord-018764-02l423mk	56	31	cells	cell	NOUN
cord-018764-02l423mk	56	32	.	.	PUNCT
cord-018764-02l423mk	57	1	both	both	DET
cord-018764-02l423mk	57	2	mechanisms	mechanism	NOUN
cord-018764-02l423mk	57	3	may	may	AUX
cord-018764-02l423mk	57	4	be	be	AUX
cord-018764-02l423mk	57	5	governed	govern	VERB
cord-018764-02l423mk	57	6	by	by	ADP
cord-018764-02l423mk	57	7	the	the	DET
cord-018764-02l423mk	57	8	host	host	NOUN
cord-018764-02l423mk	57	9	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	57	10	cytokine	cytokine	NOUN
cord-018764-02l423mk	57	11	response	response	NOUN
cord-018764-02l423mk	57	12	to	to	ADP
cord-018764-02l423mk	57	13	infection	infection	NOUN
cord-018764-02l423mk	57	14	.	.	PUNCT
cord-018764-02l423mk	58	1	this	this	DET
cord-018764-02l423mk	58	2	chapter	chapter	NOUN
cord-018764-02l423mk	58	3	focuses	focus	VERB
cord-018764-02l423mk	58	4	on	on	ADP
cord-018764-02l423mk	58	5	how	how	SCONJ
cord-018764-02l423mk	58	6	an	an	DET
cord-018764-02l423mk	58	7	increased	increase	VERB
cord-018764-02l423mk	58	8	understanding	understanding	NOUN
cord-018764-02l423mk	58	9	of	of	ADP
cord-018764-02l423mk	58	10	the	the	DET
cord-018764-02l423mk	58	11	molecular	molecular	ADJ
cord-018764-02l423mk	58	12	functions	function	NOUN
cord-018764-02l423mk	58	13	of	of	ADP
cord-018764-02l423mk	58	14	cytokines	cytokine	NOUN
cord-018764-02l423mk	58	15	during	during	ADP
cord-018764-02l423mk	58	16	disease	disease	NOUN
cord-018764-02l423mk	58	17	demonstrates	demonstrate	VERB
cord-018764-02l423mk	58	18	a	a	DET
cord-018764-02l423mk	58	19	closer	close	ADJ
cord-018764-02l423mk	58	20	alignment	alignment	NOUN
cord-018764-02l423mk	58	21	between	between	ADP
cord-018764-02l423mk	58	22	the	the	DET
cord-018764-02l423mk	58	23	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	58	24	of	of	ADP
cord-018764-02l423mk	58	25	falciparum	falciparum	NOUN
cord-018764-02l423mk	58	26	infection	infection	NOUN
cord-018764-02l423mk	58	27	and	and	CCONJ
cord-018764-02l423mk	58	28	other	other	ADJ
cord-018764-02l423mk	58	29	systemic	systemic	ADJ
cord-018764-02l423mk	58	30	infectious	infectious	ADJ
cord-018764-02l423mk	58	31	diseases	disease	NOUN
cord-018764-02l423mk	58	32	.	.	PUNCT
cord-018764-02l423mk	59	1	one	one	NUM
cord-018764-02l423mk	59	2	hundred	hundred	NUM
cord-018764-02l423mk	59	3	and	and	CCONJ
cord-018764-02l423mk	59	4	twenty	twenty	NUM
cord-018764-02l423mk	59	5	years	year	NOUN
cord-018764-02l423mk	59	6	ago	ago	ADP
cord-018764-02l423mk	59	7	,	,	PUNCT
cord-018764-02l423mk	59	8	golgi	golgi	PROPN
cord-018764-02l423mk	59	9	(	(	PUNCT
cord-018764-02l423mk	59	10	of	of	ADP
cord-018764-02l423mk	59	11	the	the	DET
cord-018764-02l423mk	59	12	golgi	golgi	NOUN
cord-018764-02l423mk	59	13	apparatus	apparatus	NOUN
cord-018764-02l423mk	60	1	[	[	PUNCT
cord-018764-02l423mk	60	2	22	22	NUM
cord-018764-02l423mk	60	3	]	]	PUNCT
cord-018764-02l423mk	60	4	)	)	PUNCT
cord-018764-02l423mk	60	5	,	,	PUNCT
cord-018764-02l423mk	60	6	noted	note	VERB
cord-018764-02l423mk	60	7	onset	onset	NOUN
cord-018764-02l423mk	60	8	of	of	ADP
cord-018764-02l423mk	60	9	malarial	malarial	ADJ
cord-018764-02l423mk	60	10	fever	fever	NOUN
cord-018764-02l423mk	60	11	and	and	CCONJ
cord-018764-02l423mk	60	12	illness	illness	NOUN
cord-018764-02l423mk	60	13	at	at	ADP
cord-018764-02l423mk	60	14	a	a	DET
cord-018764-02l423mk	60	15	predictable	predictable	ADJ
cord-018764-02l423mk	60	16	short	short	ADJ
cord-018764-02l423mk	60	17	interval	interval	NOUN
cord-018764-02l423mk	60	18	after	after	SCONJ
cord-018764-02l423mk	60	19	the	the	DET
cord-018764-02l423mk	60	20	regular	regular	ADJ
cord-018764-02l423mk	60	21	shower	shower	NOUN
cord-018764-02l423mk	60	22	of	of	ADP
cord-018764-02l423mk	60	23	new	new	ADJ
cord-018764-02l423mk	60	24	parasites	parasite	NOUN
cord-018764-02l423mk	60	25	were	be	AUX
cord-018764-02l423mk	60	26	released	release	VERB
cord-018764-02l423mk	60	27	from	from	ADP
cord-018764-02l423mk	60	28	bursting	burst	VERB
cord-018764-02l423mk	60	29	red	red	ADJ
cord-018764-02l423mk	60	30	cells	cell	NOUN
cord-018764-02l423mk	60	31	.	.	PUNCT
cord-018764-02l423mk	61	1	the	the	DET
cord-018764-02l423mk	61	2	nature	nature	NOUN
cord-018764-02l423mk	61	3	of	of	ADP
cord-018764-02l423mk	61	4	the	the	DET
cord-018764-02l423mk	61	5	putative	putative	ADJ
cord-018764-02l423mk	61	6	toxin	toxin	NOUN
cord-018764-02l423mk	61	7	so	so	ADV
cord-018764-02l423mk	61	8	released	release	VERB
cord-018764-02l423mk	61	9	was	be	AUX
cord-018764-02l423mk	61	10	much	much	ADV
cord-018764-02l423mk	61	11	discussed	discuss	VERB
cord-018764-02l423mk	61	12	in	in	ADP
cord-018764-02l423mk	61	13	the	the	DET
cord-018764-02l423mk	61	14	first	first	ADJ
cord-018764-02l423mk	61	15	decade	decade	NOUN
cord-018764-02l423mk	61	16	of	of	ADP
cord-018764-02l423mk	61	17	the	the	DET
cord-018764-02l423mk	61	18	20th	20th	ADJ
cord-018764-02l423mk	61	19	century	century	NOUN
cord-018764-02l423mk	61	20	[	[	PUNCT
cord-018764-02l423mk	61	21	23	23	NUM
cord-018764-02l423mk	61	22	]	]	PUNCT
cord-018764-02l423mk	61	23	.	.	PUNCT
cord-018764-02l423mk	62	1	it	it	PRON
cord-018764-02l423mk	62	2	was	be	AUX
cord-018764-02l423mk	62	3	assumed	assume	VERB
cord-018764-02l423mk	62	4	to	to	PART
cord-018764-02l423mk	62	5	be	be	AUX
cord-018764-02l423mk	62	6	directly	directly	ADV
cord-018764-02l423mk	62	7	toxic	toxic	ADJ
cord-018764-02l423mk	62	8	,	,	PUNCT
cord-018764-02l423mk	62	9	in	in	ADP
cord-018764-02l423mk	62	10	the	the	DET
cord-018764-02l423mk	62	11	manner	manner	NOUN
cord-018764-02l423mk	62	12	of	of	ADP
cord-018764-02l423mk	62	13	tetanus	tetanus	NOUN
cord-018764-02l423mk	62	14	toxin	toxin	NOUN
cord-018764-02l423mk	62	15	.	.	PUNCT
cord-018764-02l423mk	63	1	the	the	DET
cord-018764-02l423mk	63	2	proposal	proposal	NOUN
cord-018764-02l423mk	63	3	that	that	SCONJ
cord-018764-02l423mk	63	4	malarial	malarial	ADJ
cord-018764-02l423mk	63	5	products	product	NOUN
cord-018764-02l423mk	63	6	were	be	AUX
cord-018764-02l423mk	63	7	not	not	PART
cord-018764-02l423mk	63	8	harmful	harmful	ADJ
cord-018764-02l423mk	63	9	in	in	ADP
cord-018764-02l423mk	63	10	themselves	themselves	PRON
cord-018764-02l423mk	63	11	,	,	PUNCT
cord-018764-02l423mk	63	12	but	but	CCONJ
cord-018764-02l423mk	63	13	only	only	ADV
cord-018764-02l423mk	63	14	through	through	ADP
cord-018764-02l423mk	63	15	causing	cause	VERB
cord-018764-02l423mk	63	16	the	the	DET
cord-018764-02l423mk	63	17	infected	infect	VERB
cord-018764-02l423mk	63	18	host	host	NOUN
cord-018764-02l423mk	63	19	to	to	PART
cord-018764-02l423mk	63	20	harm	harm	VERB
cord-018764-02l423mk	63	21	itself	itself	PRON
cord-018764-02l423mk	63	22	through	through	ADP
cord-018764-02l423mk	63	23	generating	generate	VERB
cord-018764-02l423mk	63	24	toxic	toxic	ADJ
cord-018764-02l423mk	63	25	amounts	amount	NOUN
cord-018764-02l423mk	63	26	of	of	ADP
cord-018764-02l423mk	63	27	molecules	molecule	NOUN
cord-018764-02l423mk	63	28	(	(	PUNCT
cord-018764-02l423mk	63	29	pro	pro	ADJ
cord-018764-02l423mk	63	30	-	-	ADJ
cord-018764-02l423mk	63	31	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	63	32	cytokines	cytokine	NOUN
cord-018764-02l423mk	63	33	)	)	PUNCT
cord-018764-02l423mk	63	34	that	that	SCONJ
cord-018764-02l423mk	63	35	,	,	PUNCT
cord-018764-02l423mk	63	36	in	in	ADP
cord-018764-02l423mk	63	37	lower	low	ADJ
cord-018764-02l423mk	63	38	concentrations	concentration	NOUN
cord-018764-02l423mk	63	39	,	,	PUNCT
cord-018764-02l423mk	63	40	inhibit	inhibit	VERB
cord-018764-02l423mk	63	41	growth	growth	NOUN
cord-018764-02l423mk	63	42	of	of	ADP
cord-018764-02l423mk	63	43	malarial	malarial	ADJ
cord-018764-02l423mk	63	44	parasites	parasite	NOUN
cord-018764-02l423mk	63	45	did	do	AUX
cord-018764-02l423mk	63	46	not	not	PART
cord-018764-02l423mk	63	47	arise	arise	VERB
cord-018764-02l423mk	63	48	until	until	ADP
cord-018764-02l423mk	63	49	1981	1981	NUM
cord-018764-02l423mk	63	50	[	[	PUNCT
cord-018764-02l423mk	63	51	24	24	NUM
cord-018764-02l423mk	63	52	]	]	PUNCT
cord-018764-02l423mk	63	53	.	.	PUNCT
cord-018764-02l423mk	64	1	indeed	indeed	ADV
cord-018764-02l423mk	64	2	,	,	PUNCT
cord-018764-02l423mk	64	3	acceptance	acceptance	NOUN
cord-018764-02l423mk	64	4	of	of	ADP
cord-018764-02l423mk	64	5	the	the	DET
cord-018764-02l423mk	64	6	broad	broad	ADJ
cord-018764-02l423mk	64	7	applicability	applicability	NOUN
cord-018764-02l423mk	64	8	of	of	ADP
cord-018764-02l423mk	64	9	this	this	DET
cord-018764-02l423mk	64	10	concept	concept	NOUN
cord-018764-02l423mk	64	11	to	to	ADP
cord-018764-02l423mk	64	12	infectious	infectious	ADJ
cord-018764-02l423mk	64	13	disease	disease	NOUN
cord-018764-02l423mk	64	14	in	in	ADP
cord-018764-02l423mk	64	15	general	general	ADJ
cord-018764-02l423mk	64	16	is	be	AUX
cord-018764-02l423mk	64	17	now	now	ADV
cord-018764-02l423mk	64	18	sufficient	sufficient	ADJ
cord-018764-02l423mk	64	19	for	for	SCONJ
cord-018764-02l423mk	64	20	its	its	PRON
cord-018764-02l423mk	64	21	evolution	evolution	NOUN
cord-018764-02l423mk	64	22	to	to	PART
cord-018764-02l423mk	64	23	be	be	AUX
cord-018764-02l423mk	64	24	a	a	DET
cord-018764-02l423mk	64	25	subject	subject	NOUN
cord-018764-02l423mk	64	26	for	for	ADP
cord-018764-02l423mk	64	27	research	research	NOUN
cord-018764-02l423mk	64	28	[	[	X
cord-018764-02l423mk	64	29	25	25	NUM
cord-018764-02l423mk	64	30	]	]	PUNCT
cord-018764-02l423mk	64	31	.	.	PUNCT
cord-018764-02l423mk	65	1	tumour	tumour	NOUN
cord-018764-02l423mk	65	2	necrosis	necrosis	NOUN
cord-018764-02l423mk	65	3	factor	factor	NOUN
cord-018764-02l423mk	65	4	(	(	PUNCT
cord-018764-02l423mk	65	5	tnf	tnf	PROPN
cord-018764-02l423mk	65	6	)	)	PUNCT
cord-018764-02l423mk	65	7	is	be	AUX
cord-018764-02l423mk	65	8	regarded	regard	VERB
cord-018764-02l423mk	65	9	as	as	ADP
cord-018764-02l423mk	65	10	a	a	DET
cord-018764-02l423mk	65	11	major	major	ADJ
cord-018764-02l423mk	65	12	player	player	NOUN
cord-018764-02l423mk	65	13	,	,	PUNCT
cord-018764-02l423mk	65	14	malaria	malaria	NOUN
cord-018764-02l423mk	65	15	being	be	AUX
cord-018764-02l423mk	65	16	the	the	DET
cord-018764-02l423mk	65	17	first	first	ADJ
cord-018764-02l423mk	65	18	disease	disease	NOUN
cord-018764-02l423mk	65	19	in	in	ADP
cord-018764-02l423mk	65	20	which	which	PRON
cord-018764-02l423mk	65	21	it	it	PRON
cord-018764-02l423mk	65	22	was	be	AUX
cord-018764-02l423mk	65	23	proposed	propose	VERB
cord-018764-02l423mk	65	24	to	to	PART
cord-018764-02l423mk	65	25	cause	cause	VERB
cord-018764-02l423mk	65	26	systemic	systemic	ADJ
cord-018764-02l423mk	65	27	illness	illness	NOUN
cord-018764-02l423mk	65	28	and	and	CCONJ
cord-018764-02l423mk	65	29	pathology	pathology	NOUN
cord-018764-02l423mk	65	30	[	[	PUNCT
cord-018764-02l423mk	65	31	24	24	NUM
cord-018764-02l423mk	65	32	]	]	PUNCT
cord-018764-02l423mk	65	33	.	.	PUNCT
cord-018764-02l423mk	66	1	multiple	multiple	ADJ
cord-018764-02l423mk	66	2	tnf	tnf	PROPN
cord-018764-02l423mk	66	3	promoter	promoter	NOUN
cord-018764-02l423mk	66	4	polymorphisms	polymorphism	NOUN
cord-018764-02l423mk	66	5	have	have	AUX
cord-018764-02l423mk	66	6	since	since	ADV
cord-018764-02l423mk	66	7	been	be	AUX
cord-018764-02l423mk	66	8	independently	independently	ADV
cord-018764-02l423mk	66	9	associated	associate	VERB
cord-018764-02l423mk	66	10	with	with	ADP
cord-018764-02l423mk	66	11	severe	severe	ADJ
cord-018764-02l423mk	66	12	malaria	malaria	NOUN
cord-018764-02l423mk	66	13	across	across	ADP
cord-018764-02l423mk	66	14	several	several	ADJ
cord-018764-02l423mk	66	15	geographical	geographical	ADJ
cord-018764-02l423mk	66	16	populations	population	NOUN
cord-018764-02l423mk	66	17	[	[	PUNCT
cord-018764-02l423mk	66	18	26	26	NUM
cord-018764-02l423mk	66	19	]	]	PUNCT
cord-018764-02l423mk	66	20	.	.	PUNCT
cord-018764-02l423mk	67	1	a	a	DET
cord-018764-02l423mk	67	2	longitudinal	longitudinal	ADJ
cord-018764-02l423mk	67	3	study	study	NOUN
cord-018764-02l423mk	67	4	in	in	ADP
cord-018764-02l423mk	67	5	burkino	burkino	PROPN
cord-018764-02l423mk	67	6	faso	faso	NOUN
cord-018764-02l423mk	67	7	has	have	AUX
cord-018764-02l423mk	67	8	also	also	ADV
cord-018764-02l423mk	67	9	demonstrated	demonstrate	VERB
cord-018764-02l423mk	67	10	several	several	ADJ
cord-018764-02l423mk	67	11	tnf	tnf	PROPN
cord-018764-02l423mk	67	12	promoter	promoter	NOUN
cord-018764-02l423mk	67	13	polymorphisms	polymorphism	NOUN
cord-018764-02l423mk	67	14	associated	associate	VERB
cord-018764-02l423mk	67	15	with	with	ADP
cord-018764-02l423mk	67	16	the	the	DET
cord-018764-02l423mk	67	17	regulation	regulation	NOUN
cord-018764-02l423mk	67	18	of	of	ADP
cord-018764-02l423mk	67	19	host	host	NOUN
cord-018764-02l423mk	67	20	-	-	PUNCT
cord-018764-02l423mk	67	21	parasite	parasite	NOUN
cord-018764-02l423mk	67	22	density	density	NOUN
cord-018764-02l423mk	67	23	[	[	X
cord-018764-02l423mk	67	24	27	27	NUM
cord-018764-02l423mk	67	25	]	]	PUNCT
cord-018764-02l423mk	67	26	.	.	PUNCT
cord-018764-02l423mk	68	1	the	the	DET
cord-018764-02l423mk	68	2	tnf	tnf	PROPN
cord-018764-02l423mk	68	3	concept	concept	NOUN
cord-018764-02l423mk	68	4	has	have	AUX
cord-018764-02l423mk	68	5	since	since	SCONJ
cord-018764-02l423mk	68	6	begun	begin	VERB
cord-018764-02l423mk	68	7	to	to	PART
cord-018764-02l423mk	68	8	dominate	dominate	VERB
cord-018764-02l423mk	68	9	the	the	DET
cord-018764-02l423mk	68	10	sepsis	sepsis	NOUN
cord-018764-02l423mk	68	11	literature	literature	NOUN
cord-018764-02l423mk	68	12	[	[	PUNCT
cord-018764-02l423mk	68	13	28	28	NUM
cord-018764-02l423mk	68	14	]	]	PUNCT
cord-018764-02l423mk	68	15	,	,	PUNCT
cord-018764-02l423mk	68	16	and	and	CCONJ
cord-018764-02l423mk	68	17	the	the	DET
cord-018764-02l423mk	68	18	virulence	virulence	NOUN
cord-018764-02l423mk	68	19	of	of	ADP
cord-018764-02l423mk	68	20	different	different	ADJ
cord-018764-02l423mk	68	21	strains	strain	NOUN
cord-018764-02l423mk	68	22	of	of	ADP
cord-018764-02l423mk	68	23	influenza	influenza	NOUN
cord-018764-02l423mk	68	24	,	,	PUNCT
cord-018764-02l423mk	68	25	a	a	DET
cord-018764-02l423mk	68	26	disease	disease	NOUN
cord-018764-02l423mk	68	27	that	that	PRON
cord-018764-02l423mk	68	28	is	be	AUX
cord-018764-02l423mk	68	29	a	a	DET
cord-018764-02l423mk	68	30	standard	standard	ADJ
cord-018764-02l423mk	68	31	clinical	clinical	ADJ
cord-018764-02l423mk	68	32	misdiagnosis	misdiagnosis	NOUN
cord-018764-02l423mk	68	33	for	for	ADP
cord-018764-02l423mk	68	34	imported	import	VERB
cord-018764-02l423mk	68	35	malaria	malaria	NOUN
cord-018764-02l423mk	68	36	,	,	PUNCT
cord-018764-02l423mk	68	37	has	have	AUX
cord-018764-02l423mk	68	38	recently	recently	ADV
cord-018764-02l423mk	68	39	been	be	AUX
cord-018764-02l423mk	68	40	expressed	express	VERB
cord-018764-02l423mk	68	41	in	in	ADP
cord-018764-02l423mk	68	42	terms	term	NOUN
cord-018764-02l423mk	68	43	of	of	ADP
cord-018764-02l423mk	68	44	their	their	PRON
cord-018764-02l423mk	68	45	capacity	capacity	NOUN
cord-018764-02l423mk	68	46	to	to	PART
cord-018764-02l423mk	68	47	induce	induce	VERB
cord-018764-02l423mk	68	48	tnf	tnf	PROPN
cord-018764-02l423mk	69	1	[	[	PUNCT
cord-018764-02l423mk	69	2	29	29	NUM
cord-018764-02l423mk	69	3	]	]	PUNCT
cord-018764-02l423mk	69	4	.	.	PUNCT
cord-018764-02l423mk	70	1	the	the	DET
cord-018764-02l423mk	70	2	critical	critical	ADJ
cord-018764-02l423mk	70	3	role	role	NOUN
cord-018764-02l423mk	70	4	of	of	ADP
cord-018764-02l423mk	70	5	tnf	tnf	PROPN
cord-018764-02l423mk	70	6	in	in	ADP
cord-018764-02l423mk	70	7	both	both	DET
cord-018764-02l423mk	70	8	malaria	malaria	NOUN
cord-018764-02l423mk	70	9	and	and	CCONJ
cord-018764-02l423mk	70	10	influenza	influenza	NOUN
cord-018764-02l423mk	70	11	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	70	12	is	be	AUX
cord-018764-02l423mk	70	13	consistent	consistent	ADJ
cord-018764-02l423mk	70	14	with	with	ADP
cord-018764-02l423mk	70	15	the	the	DET
cord-018764-02l423mk	70	16	clinical	clinical	ADJ
cord-018764-02l423mk	70	17	similarities	similarity	NOUN
cord-018764-02l423mk	70	18	between	between	ADP
cord-018764-02l423mk	70	19	the	the	DET
cord-018764-02l423mk	70	20	diseases	disease	NOUN
cord-018764-02l423mk	70	21	.	.	PUNCT
cord-018764-02l423mk	71	1	indeed	indeed	ADV
cord-018764-02l423mk	71	2	,	,	PUNCT
cord-018764-02l423mk	71	3	tnf	tnf	PROPN
cord-018764-02l423mk	71	4	infusions	infusion	NOUN
cord-018764-02l423mk	71	5	in	in	ADP
cord-018764-02l423mk	71	6	tumour	tumour	NOUN
cord-018764-02l423mk	71	7	patients	patient	NOUN
cord-018764-02l423mk	71	8	produce	produce	VERB
cord-018764-02l423mk	71	9	side	side	NOUN
cord-018764-02l423mk	71	10	effects	effect	NOUN
cord-018764-02l423mk	71	11	mimicking	mimic	VERB
cord-018764-02l423mk	71	12	both	both	DET
cord-018764-02l423mk	71	13	diseases	disease	NOUN
cord-018764-02l423mk	71	14	[	[	PUNCT
cord-018764-02l423mk	71	15	30	30	NUM
cord-018764-02l423mk	71	16	]	]	PUNCT
cord-018764-02l423mk	71	17	,	,	PUNCT
cord-018764-02l423mk	71	18	as	as	SCONJ
cord-018764-02l423mk	71	19	discussed	discuss	VERB
cord-018764-02l423mk	71	20	below	below	ADP
cord-018764-02l423mk	71	21	.	.	PUNCT
cord-018764-02l423mk	72	1	although	although	SCONJ
cord-018764-02l423mk	72	2	tnf	tnf	PROPN
cord-018764-02l423mk	72	3	is	be	AUX
cord-018764-02l423mk	72	4	the	the	DET
cord-018764-02l423mk	72	5	prototype	prototype	NOUN
cord-018764-02l423mk	72	6	pro	pro	ADJ
cord-018764-02l423mk	72	7	-	-	ADJ
cord-018764-02l423mk	72	8	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	72	9	cytokine	cytokine	NOUN
cord-018764-02l423mk	72	10	linked	link	VERB
cord-018764-02l423mk	72	11	with	with	ADP
cord-018764-02l423mk	72	12	severe	severe	ADJ
cord-018764-02l423mk	72	13	malaria	malaria	NOUN
cord-018764-02l423mk	72	14	,	,	PUNCT
cord-018764-02l423mk	72	15	other	other	ADJ
cord-018764-02l423mk	72	16	cytokines	cytokine	NOUN
cord-018764-02l423mk	72	17	(	(	PUNCT
cord-018764-02l423mk	72	18	and	and	CCONJ
cord-018764-02l423mk	72	19	mediators	mediator	NOUN
cord-018764-02l423mk	72	20	)	)	PUNCT
cord-018764-02l423mk	72	21	including	include	VERB
cord-018764-02l423mk	72	22	interferon	interferon	NOUN
cord-018764-02l423mk	72	23	(	(	PUNCT
cord-018764-02l423mk	72	24	ifn)[31	ifn)[31	X
cord-018764-02l423mk	72	25	]	]	X
cord-018764-02l423mk	72	26	,	,	PUNCT
cord-018764-02l423mk	72	27	its	its	PRON
cord-018764-02l423mk	72	28	corresponding	corresponding	ADJ
cord-018764-02l423mk	72	29	receptors	receptor	NOUN
cord-018764-02l423mk	72	30	ifn	ifn	VERB
cord-018764-02l423mk	72	31	-	-	PUNCT
cord-018764-02l423mk	72	32	receptor-1	receptor-1	NOUN
cord-018764-02l423mk	72	33	[	[	X
cord-018764-02l423mk	72	34	32	32	NUM
cord-018764-02l423mk	72	35	]	]	PUNCT
cord-018764-02l423mk	72	36	and	and	CCONJ
cord-018764-02l423mk	72	37	ifn	ifn	NOUN
cord-018764-02l423mk	72	38	-	-	PUNCT
cord-018764-02l423mk	72	39	receptor-1	receptor-1	NOUN
cord-018764-02l423mk	73	1	[	[	X
cord-018764-02l423mk	73	2	33	33	NUM
cord-018764-02l423mk	73	3	]	]	PUNCT
cord-018764-02l423mk	73	4	,	,	PUNCT
cord-018764-02l423mk	73	5	il-1	il-1	PUNCT
cord-018764-02l423mk	74	1	[	[	X
cord-018764-02l423mk	74	2	34	34	NUM
cord-018764-02l423mk	74	3	]	]	PUNCT
cord-018764-02l423mk	74	4	,	,	PUNCT
cord-018764-02l423mk	74	5	il-4	il-4	NOUN
cord-018764-02l423mk	74	6	[	[	X
cord-018764-02l423mk	74	7	35	35	NUM
cord-018764-02l423mk	74	8	]	]	PUNCT
cord-018764-02l423mk	74	9	and	and	CCONJ
cord-018764-02l423mk	74	10	il-10	il-10	X
cord-018764-02l423mk	74	11	[	[	X
cord-018764-02l423mk	74	12	36	36	NUM
cord-018764-02l423mk	74	13	]	]	PUNCT
cord-018764-02l423mk	74	14	have	have	AUX
cord-018764-02l423mk	74	15	all	all	PRON
cord-018764-02l423mk	74	16	be	be	AUX
cord-018764-02l423mk	74	17	identified	identify	VERB
cord-018764-02l423mk	74	18	through	through	ADP
cord-018764-02l423mk	74	19	genetic	genetic	ADJ
cord-018764-02l423mk	74	20	association	association	NOUN
cord-018764-02l423mk	74	21	analysis	analysis	NOUN
cord-018764-02l423mk	74	22	to	to	PART
cord-018764-02l423mk	74	23	be	be	AUX
cord-018764-02l423mk	74	24	linked	link	VERB
cord-018764-02l423mk	74	25	with	with	ADP
cord-018764-02l423mk	74	26	their	their	PRON
cord-018764-02l423mk	74	27	potential	potential	ADJ
cord-018764-02l423mk	74	28	regulation	regulation	NOUN
cord-018764-02l423mk	74	29	of	of	ADP
cord-018764-02l423mk	74	30	malarial	malarial	ADJ
cord-018764-02l423mk	74	31	disease	disease	NOUN
cord-018764-02l423mk	74	32	severity	severity	NOUN
cord-018764-02l423mk	74	33	.	.	PUNCT
cord-018764-02l423mk	75	1	all	all	DET
cord-018764-02l423mk	75	2	the	the	DET
cord-018764-02l423mk	75	3	above	above	ADJ
cord-018764-02l423mk	75	4	cytokines	cytokine	NOUN
cord-018764-02l423mk	75	5	typically	typically	ADV
cord-018764-02l423mk	75	6	act	act	VERB
cord-018764-02l423mk	75	7	as	as	ADP
cord-018764-02l423mk	75	8	homeostatic	homeostatic	ADJ
cord-018764-02l423mk	75	9	agents	agent	NOUN
cord-018764-02l423mk	75	10	,	,	PUNCT
cord-018764-02l423mk	75	11	but	but	CCONJ
cord-018764-02l423mk	75	12	can	can	AUX
cord-018764-02l423mk	75	13	cause	cause	VERB
cord-018764-02l423mk	75	14	pathology	pathology	NOUN
cord-018764-02l423mk	75	15	if	if	SCONJ
cord-018764-02l423mk	75	16	produced	produce	VERB
cord-018764-02l423mk	75	17	excessively	excessively	ADV
cord-018764-02l423mk	75	18	.	.	PUNCT
cord-018764-02l423mk	76	1	when	when	SCONJ
cord-018764-02l423mk	76	2	this	this	PRON
cord-018764-02l423mk	76	3	happens	happen	VERB
cord-018764-02l423mk	76	4	they	they	PRON
cord-018764-02l423mk	76	5	also	also	ADV
cord-018764-02l423mk	76	6	induce	induce	VERB
cord-018764-02l423mk	76	7	a	a	DET
cord-018764-02l423mk	76	8	late	late	ADJ
cord-018764-02l423mk	76	9	-	-	PUNCT
cord-018764-02l423mk	76	10	onset	onset	NOUN
cord-018764-02l423mk	76	11	,	,	PUNCT
cord-018764-02l423mk	76	12	but	but	CCONJ
cord-018764-02l423mk	76	13	long	long	ADJ
cord-018764-02l423mk	76	14	-	-	PUNCT
cord-018764-02l423mk	76	15	acting	act	VERB
cord-018764-02l423mk	76	16	cytokine	cytokine	NOUN
cord-018764-02l423mk	76	17	termed	term	VERB
cord-018764-02l423mk	76	18	the	the	DET
cord-018764-02l423mk	76	19	high	high	ADJ
cord-018764-02l423mk	76	20	mobility	mobility	NOUN
cord-018764-02l423mk	76	21	group	group	NOUN
cord-018764-02l423mk	76	22	box	box	PROPN
cord-018764-02l423mk	76	23	1	1	NUM
cord-018764-02l423mk	76	24	(	(	PUNCT
cord-018764-02l423mk	76	25	hmgb1	hmgb1	PROPN
cord-018764-02l423mk	76	26	)	)	PUNCT
cord-018764-02l423mk	76	27	protein	protein	NOUN
cord-018764-02l423mk	76	28	,	,	PUNCT
cord-018764-02l423mk	76	29	which	which	PRON
cord-018764-02l423mk	76	30	prolongs	prolong	VERB
cord-018764-02l423mk	76	31	and	and	CCONJ
cord-018764-02l423mk	76	32	amplifies	amplify	VERB
cord-018764-02l423mk	76	33	inflammation	inflammation	NOUN
cord-018764-02l423mk	76	34	[	[	X
cord-018764-02l423mk	76	35	37	37	NUM
cord-018764-02l423mk	76	36	,	,	PUNCT
cord-018764-02l423mk	76	37	38	38	NUM
cord-018764-02l423mk	76	38	]	]	PUNCT
cord-018764-02l423mk	76	39	.	.	PUNCT
cord-018764-02l423mk	77	1	this	this	DET
cord-018764-02l423mk	77	2	molecule	molecule	NOUN
cord-018764-02l423mk	77	3	,	,	PUNCT
cord-018764-02l423mk	77	4	normally	normally	ADV
cord-018764-02l423mk	77	5	in	in	ADP
cord-018764-02l423mk	77	6	the	the	DET
cord-018764-02l423mk	77	7	cellular	cellular	ADJ
cord-018764-02l423mk	77	8	nucleus	nucleus	NOUN
cord-018764-02l423mk	77	9	and	and	CCONJ
cord-018764-02l423mk	77	10	previously	previously	ADV
cord-018764-02l423mk	77	11	known	know	VERB
cord-018764-02l423mk	77	12	only	only	ADV
cord-018764-02l423mk	77	13	for	for	ADP
cord-018764-02l423mk	77	14	several	several	ADJ
cord-018764-02l423mk	77	15	physiological	physiological	ADJ
cord-018764-02l423mk	77	16	functions	function	NOUN
cord-018764-02l423mk	77	17	,	,	PUNCT
cord-018764-02l423mk	77	18	now	now	ADV
cord-018764-02l423mk	77	19	shows	show	VERB
cord-018764-02l423mk	77	20	great	great	ADJ
cord-018764-02l423mk	77	21	promise	promise	NOUN
cord-018764-02l423mk	77	22	as	as	ADP
cord-018764-02l423mk	77	23	a	a	DET
cord-018764-02l423mk	77	24	therapeutic	therapeutic	ADJ
cord-018764-02l423mk	77	25	target	target	NOUN
cord-018764-02l423mk	77	26	in	in	ADP
cord-018764-02l423mk	77	27	sepsis	sepsis	NOUN
cord-018764-02l423mk	77	28	,	,	PUNCT
cord-018764-02l423mk	77	29	in	in	ADP
cord-018764-02l423mk	77	30	that	that	PRON
cord-018764-02l423mk	77	31	countering	counter	VERB
cord-018764-02l423mk	77	32	it	it	PRON
cord-018764-02l423mk	77	33	after	after	ADP
cord-018764-02l423mk	77	34	the	the	DET
cord-018764-02l423mk	77	35	onset	onset	NOUN
cord-018764-02l423mk	77	36	of	of	ADP
cord-018764-02l423mk	77	37	illness	illness	NOUN
cord-018764-02l423mk	77	38	protects	protect	VERB
cord-018764-02l423mk	77	39	well	well	ADV
cord-018764-02l423mk	77	40	in	in	ADP
cord-018764-02l423mk	77	41	experimental	experimental	ADJ
cord-018764-02l423mk	77	42	sepsis	sepsis	NOUN
cord-018764-02l423mk	77	43	[	[	PUNCT
cord-018764-02l423mk	77	44	39	39	NUM
cord-018764-02l423mk	77	45	,	,	PUNCT
cord-018764-02l423mk	77	46	40	40	NUM
cord-018764-02l423mk	77	47	]	]	PUNCT
cord-018764-02l423mk	77	48	.	.	PUNCT
cord-018764-02l423mk	78	1	it	it	PRON
cord-018764-02l423mk	78	2	accumulates	accumulate	VERB
cord-018764-02l423mk	78	3	,	,	PUNCT
cord-018764-02l423mk	78	4	in	in	ADP
cord-018764-02l423mk	78	5	proportion	proportion	NOUN
cord-018764-02l423mk	78	6	to	to	ADP
cord-018764-02l423mk	78	7	degree	degree	NOUN
cord-018764-02l423mk	78	8	of	of	ADP
cord-018764-02l423mk	78	9	illness	illness	NOUN
cord-018764-02l423mk	78	10	,	,	PUNCT
cord-018764-02l423mk	78	11	in	in	ADP
cord-018764-02l423mk	78	12	serum	serum	NOUN
cord-018764-02l423mk	78	13	from	from	ADP
cord-018764-02l423mk	78	14	african	african	ADJ
cord-018764-02l423mk	78	15	children	child	NOUN
cord-018764-02l423mk	78	16	infected	infect	VERB
cord-018764-02l423mk	78	17	with	with	ADP
cord-018764-02l423mk	78	18	falciparum	falciparum	PROPN
cord-018764-02l423mk	78	19	malaria	malaria	NOUN
cord-018764-02l423mk	78	20	[	[	X
cord-018764-02l423mk	78	21	41	41	NUM
cord-018764-02l423mk	78	22	]	]	PUNCT
cord-018764-02l423mk	78	23	.	.	PUNCT
cord-018764-02l423mk	79	1	once	once	SCONJ
cord-018764-02l423mk	79	2	neutralising	neutralise	VERB
cord-018764-02l423mk	79	3	anti	anti	ADJ
cord-018764-02l423mk	79	4	-	-	ADJ
cord-018764-02l423mk	79	5	tnf	tnf	ADJ
cord-018764-02l423mk	79	6	antibodies	antibody	NOUN
cord-018764-02l423mk	79	7	became	become	VERB
cord-018764-02l423mk	79	8	available	available	ADJ
cord-018764-02l423mk	79	9	for	for	ADP
cord-018764-02l423mk	79	10	human	human	ADJ
cord-018764-02l423mk	79	11	use	use	NOUN
cord-018764-02l423mk	79	12	,	,	PUNCT
cord-018764-02l423mk	79	13	they	they	PRON
cord-018764-02l423mk	79	14	were	be	AUX
cord-018764-02l423mk	79	15	tested	test	VERB
cord-018764-02l423mk	79	16	for	for	ADP
cord-018764-02l423mk	79	17	efficacy	efficacy	NOUN
cord-018764-02l423mk	79	18	against	against	ADP
cord-018764-02l423mk	79	19	malarial	malarial	ADJ
cord-018764-02l423mk	79	20	disease	disease	NOUN
cord-018764-02l423mk	79	21	.	.	PUNCT
cord-018764-02l423mk	80	1	unfortunately	unfortunately	ADV
cord-018764-02l423mk	80	2	,	,	PUNCT
cord-018764-02l423mk	80	3	a	a	DET
cord-018764-02l423mk	80	4	central	central	ADJ
cord-018764-02l423mk	80	5	tenet	tenet	NOUN
cord-018764-02l423mk	80	6	of	of	ADP
cord-018764-02l423mk	80	7	the	the	DET
cord-018764-02l423mk	80	8	cytokine	cytokine	NOUN
cord-018764-02l423mk	80	9	concept	concept	NOUN
cord-018764-02l423mk	80	10	of	of	ADP
cord-018764-02l423mk	80	11	infectious	infectious	ADJ
cord-018764-02l423mk	80	12	disease	disease	NOUN
cord-018764-02l423mk	80	13	(	(	PUNCT
cord-018764-02l423mk	80	14	that	that	SCONJ
cord-018764-02l423mk	80	15	the	the	DET
cord-018764-02l423mk	80	16	proinflammatory	proinflammatory	ADJ
cord-018764-02l423mk	80	17	cytokines	cytokine	NOUN
cord-018764-02l423mk	80	18	that	that	PRON
cord-018764-02l423mk	80	19	cause	cause	VERB
cord-018764-02l423mk	80	20	disease	disease	NOUN
cord-018764-02l423mk	80	21	are	be	AUX
cord-018764-02l423mk	80	22	the	the	DET
cord-018764-02l423mk	80	23	same	same	ADJ
cord-018764-02l423mk	80	24	mediators	mediator	NOUN
cord-018764-02l423mk	80	25	that	that	PRON
cord-018764-02l423mk	80	26	,	,	PUNCT
cord-018764-02l423mk	80	27	in	in	ADP
cord-018764-02l423mk	80	28	lower	low	ADJ
cord-018764-02l423mk	80	29	concentrations	concentration	NOUN
cord-018764-02l423mk	80	30	,	,	PUNCT
cord-018764-02l423mk	80	31	are	be	AUX
cord-018764-02l423mk	80	32	responsible	responsible	ADJ
cord-018764-02l423mk	80	33	for	for	ADP
cord-018764-02l423mk	80	34	the	the	DET
cord-018764-02l423mk	80	35	innate	innate	ADJ
cord-018764-02l423mk	80	36	immunity	immunity	NOUN
cord-018764-02l423mk	80	37	that	that	PRON
cord-018764-02l423mk	80	38	controls	control	VERB
cord-018764-02l423mk	80	39	parasite	parasite	ADJ
cord-018764-02l423mk	80	40	growth	growth	NOUN
cord-018764-02l423mk	80	41	)	)	PUNCT
cord-018764-02l423mk	80	42	was	be	AUX
cord-018764-02l423mk	80	43	not	not	PART
cord-018764-02l423mk	80	44	taken	take	VERB
cord-018764-02l423mk	80	45	into	into	ADP
cord-018764-02l423mk	80	46	consideration	consideration	NOUN
cord-018764-02l423mk	80	47	.	.	PUNCT
cord-018764-02l423mk	81	1	tnf	tnf	PROPN
cord-018764-02l423mk	81	2	has	have	AUX
cord-018764-02l423mk	81	3	been	be	AUX
cord-018764-02l423mk	81	4	shown	show	VERB
cord-018764-02l423mk	81	5	to	to	PART
cord-018764-02l423mk	81	6	inhibit	inhibit	VERB
cord-018764-02l423mk	81	7	a	a	DET
cord-018764-02l423mk	81	8	mouse	mouse	NOUN
cord-018764-02l423mk	81	9	malarial	malarial	ADJ
cord-018764-02l423mk	81	10	parasite	parasite	NOUN
cord-018764-02l423mk	81	11	in	in	ADP
cord-018764-02l423mk	81	12	vivo	vivo	NOUN
cord-018764-02l423mk	82	1	[	[	X
cord-018764-02l423mk	82	2	42	42	NUM
cord-018764-02l423mk	82	3	]	]	PUNCT
cord-018764-02l423mk	82	4	,	,	PUNCT
cord-018764-02l423mk	82	5	and	and	CCONJ
cord-018764-02l423mk	82	6	p.	p.	NOUN
cord-018764-02l423mk	82	7	falciparum	falciparum	NOUN
cord-018764-02l423mk	82	8	in	in	ADP
cord-018764-02l423mk	82	9	vitro	vitro	X
cord-018764-02l423mk	82	10	,	,	PUNCT
cord-018764-02l423mk	82	11	provided	provide	VERB
cord-018764-02l423mk	82	12	white	white	ADJ
cord-018764-02l423mk	82	13	cells	cell	NOUN
cord-018764-02l423mk	82	14	to	to	PART
cord-018764-02l423mk	82	15	generate	generate	VERB
cord-018764-02l423mk	82	16	the	the	DET
cord-018764-02l423mk	82	17	next	next	ADJ
cord-018764-02l423mk	82	18	down	down	ADJ
cord-018764-02l423mk	82	19	-	-	PUNCT
cord-018764-02l423mk	82	20	stream	stream	NOUN
cord-018764-02l423mk	82	21	mediator	mediator	NOUN
cord-018764-02l423mk	82	22	,	,	PUNCT
cord-018764-02l423mk	82	23	possibly	possibly	ADV
cord-018764-02l423mk	82	24	nitric	nitric	NOUN
cord-018764-02l423mk	82	25	oxide	oxide	NOUN
cord-018764-02l423mk	82	26	(	(	PUNCT
cord-018764-02l423mk	82	27	no	no	INTJ
cord-018764-02l423mk	82	28	)	)	PUNCT
cord-018764-02l423mk	83	1	[	[	X
cord-018764-02l423mk	83	2	43	43	NUM
cord-018764-02l423mk	83	3	]	]	PUNCT
cord-018764-02l423mk	83	4	,	,	PUNCT
cord-018764-02l423mk	83	5	were	be	AUX
cord-018764-02l423mk	83	6	present	present	ADJ
cord-018764-02l423mk	83	7	[	[	X
cord-018764-02l423mk	83	8	44	44	NUM
cord-018764-02l423mk	83	9	]	]	PUNCT
cord-018764-02l423mk	83	10	.	.	PUNCT
cord-018764-02l423mk	84	1	this	this	PRON
cord-018764-02l423mk	84	2	is	be	AUX
cord-018764-02l423mk	84	3	consistent	consistent	ADJ
cord-018764-02l423mk	84	4	with	with	ADP
cord-018764-02l423mk	84	5	findings	finding	NOUN
cord-018764-02l423mk	84	6	in	in	ADP
cord-018764-02l423mk	84	7	human	human	ADJ
cord-018764-02l423mk	84	8	subjects	subject	NOUN
cord-018764-02l423mk	84	9	[	[	X
cord-018764-02l423mk	84	10	45	45	NUM
cord-018764-02l423mk	84	11	]	]	PUNCT
cord-018764-02l423mk	84	12	.	.	PUNCT
cord-018764-02l423mk	85	1	thus	thus	ADV
cord-018764-02l423mk	85	2	,	,	PUNCT
cord-018764-02l423mk	85	3	it	it	PRON
cord-018764-02l423mk	85	4	is	be	AUX
cord-018764-02l423mk	85	5	not	not	PART
cord-018764-02l423mk	85	6	surprising	surprising	ADJ
cord-018764-02l423mk	85	7	that	that	SCONJ
cord-018764-02l423mk	85	8	anti	anti	ADJ
cord-018764-02l423mk	85	9	-	-	ADJ
cord-018764-02l423mk	85	10	tnf	tnf	ADJ
cord-018764-02l423mk	85	11	antibody	antibody	NOUN
cord-018764-02l423mk	85	12	,	,	PUNCT
cord-018764-02l423mk	85	13	by	by	ADP
cord-018764-02l423mk	85	14	removing	remove	VERB
cord-018764-02l423mk	85	15	inhibitory	inhibitory	ADJ
cord-018764-02l423mk	85	16	pressure	pressure	NOUN
cord-018764-02l423mk	85	17	from	from	ADP
cord-018764-02l423mk	85	18	the	the	DET
cord-018764-02l423mk	85	19	pathogen	pathogen	PROPN
cord-018764-02l423mk	85	20	,	,	PUNCT
cord-018764-02l423mk	85	21	can	can	AUX
cord-018764-02l423mk	85	22	enhance	enhance	VERB
cord-018764-02l423mk	85	23	the	the	DET
cord-018764-02l423mk	85	24	disease	disease	NOUN
cord-018764-02l423mk	85	25	in	in	ADP
cord-018764-02l423mk	85	26	falciparum	falciparum	NOUN
cord-018764-02l423mk	85	27	malaria	malaria	NOUN
cord-018764-02l423mk	86	1	[	[	X
cord-018764-02l423mk	86	2	46	46	NUM
cord-018764-02l423mk	86	3	]	]	PUNCT
cord-018764-02l423mk	86	4	,	,	PUNCT
cord-018764-02l423mk	86	5	as	as	SCONJ
cord-018764-02l423mk	86	6	shown	show	VERB
cord-018764-02l423mk	86	7	5	5	NUM
cord-018764-02l423mk	86	8	years	year	NOUN
cord-018764-02l423mk	86	9	earlier	early	ADV
cord-018764-02l423mk	86	10	in	in	ADP
cord-018764-02l423mk	86	11	human	human	ADJ
cord-018764-02l423mk	86	12	sepsis	sepsis	NOUN
cord-018764-02l423mk	86	13	[	[	X
cord-018764-02l423mk	86	14	47	47	NUM
cord-018764-02l423mk	86	15	]	]	PUNCT
cord-018764-02l423mk	86	16	.	.	PUNCT
cord-018764-02l423mk	87	1	cytokines	cytokine	NOUN
cord-018764-02l423mk	87	2	as	as	ADP
cord-018764-02l423mk	87	3	a	a	DET
cord-018764-02l423mk	87	4	disease	disease	NOUN
cord-018764-02l423mk	87	5	mechanism	mechanism	NOUN
cord-018764-02l423mk	87	6	extends	extend	VERB
cord-018764-02l423mk	87	7	beyond	beyond	ADP
cord-018764-02l423mk	87	8	malaria	malaria	NOUN
cord-018764-02l423mk	87	9	as	as	SCONJ
cord-018764-02l423mk	87	10	noted	note	VERB
cord-018764-02l423mk	87	11	above	above	ADV
cord-018764-02l423mk	87	12	,	,	PUNCT
cord-018764-02l423mk	87	13	the	the	DET
cord-018764-02l423mk	87	14	idea	idea	NOUN
cord-018764-02l423mk	87	15	that	that	SCONJ
cord-018764-02l423mk	87	16	excessive	excessive	ADJ
cord-018764-02l423mk	87	17	production	production	NOUN
cord-018764-02l423mk	87	18	of	of	ADP
cord-018764-02l423mk	87	19	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	87	20	cytokines	cytokine	NOUN
cord-018764-02l423mk	87	21	underlies	underlie	VERB
cord-018764-02l423mk	87	22	the	the	DET
cord-018764-02l423mk	87	23	pathology	pathology	NOUN
cord-018764-02l423mk	87	24	of	of	ADP
cord-018764-02l423mk	87	25	illness	illness	NOUN
cord-018764-02l423mk	87	26	is	be	AUX
cord-018764-02l423mk	87	27	used	use	VERB
cord-018764-02l423mk	87	28	widely	widely	ADV
cord-018764-02l423mk	87	29	,	,	PUNCT
cord-018764-02l423mk	87	30	from	from	ADP
cord-018764-02l423mk	87	31	malaria	malaria	NOUN
cord-018764-02l423mk	87	32	across	across	ADP
cord-018764-02l423mk	87	33	a	a	DET
cord-018764-02l423mk	87	34	range	range	NOUN
cord-018764-02l423mk	87	35	of	of	ADP
cord-018764-02l423mk	87	36	conditions	condition	NOUN
cord-018764-02l423mk	87	37	,	,	PUNCT
cord-018764-02l423mk	87	38	infectious	infectious	ADJ
cord-018764-02l423mk	87	39	or	or	CCONJ
cord-018764-02l423mk	87	40	otherwise	otherwise	ADV
cord-018764-02l423mk	87	41	.	.	PUNCT
cord-018764-02l423mk	88	1	as	as	SCONJ
cord-018764-02l423mk	88	2	reviewed	review	VERB
cord-018764-02l423mk	88	3	recently	recently	ADV
cord-018764-02l423mk	88	4	[	[	X
cord-018764-02l423mk	88	5	48	48	NUM
cord-018764-02l423mk	88	6	]	]	PUNCT
cord-018764-02l423mk	88	7	,	,	PUNCT
cord-018764-02l423mk	88	8	this	this	PRON
cord-018764-02l423mk	88	9	now	now	ADV
cord-018764-02l423mk	88	10	includes	include	VERB
cord-018764-02l423mk	88	11	the	the	DET
cord-018764-02l423mk	88	12	illnesses	illness	NOUN
cord-018764-02l423mk	88	13	caused	cause	VERB
cord-018764-02l423mk	88	14	by	by	ADP
cord-018764-02l423mk	88	15	rickettsias	rickettsia	NOUN
cord-018764-02l423mk	88	16	,	,	PUNCT
cord-018764-02l423mk	88	17	protozoa	protozoan	NOUN
cord-018764-02l423mk	88	18	other	other	ADJ
cord-018764-02l423mk	88	19	than	than	ADP
cord-018764-02l423mk	88	20	malaria	malaria	NOUN
cord-018764-02l423mk	88	21	,	,	PUNCT
cord-018764-02l423mk	88	22	and	and	CCONJ
cord-018764-02l423mk	88	23	viruses	virus	NOUN
cord-018764-02l423mk	88	24	.	.	PUNCT
cord-018764-02l423mk	89	1	increased	increase	VERB
cord-018764-02l423mk	89	2	circulating	circulate	VERB
cord-018764-02l423mk	89	3	levels	level	NOUN
cord-018764-02l423mk	89	4	of	of	ADP
cord-018764-02l423mk	89	5	these	these	DET
cord-018764-02l423mk	89	6	cytokines	cytokine	NOUN
cord-018764-02l423mk	89	7	have	have	AUX
cord-018764-02l423mk	89	8	been	be	AUX
cord-018764-02l423mk	89	9	detected	detect	VERB
cord-018764-02l423mk	89	10	in	in	ADP
cord-018764-02l423mk	89	11	the	the	DET
cord-018764-02l423mk	89	12	serum	serum	NOUN
cord-018764-02l423mk	89	13	very	very	ADV
cord-018764-02l423mk	89	14	soon	soon	ADV
cord-018764-02l423mk	89	15	after	after	ADP
cord-018764-02l423mk	89	16	onset	onset	NOUN
cord-018764-02l423mk	89	17	of	of	ADP
cord-018764-02l423mk	89	18	illness	illness	NOUN
cord-018764-02l423mk	89	19	in	in	ADP
cord-018764-02l423mk	89	20	virtually	virtually	ADV
cord-018764-02l423mk	89	21	all	all	DET
cord-018764-02l423mk	89	22	those	those	DET
cord-018764-02l423mk	89	23	infectious	infectious	ADJ
cord-018764-02l423mk	89	24	diseases	disease	NOUN
cord-018764-02l423mk	89	25	in	in	ADP
cord-018764-02l423mk	89	26	which	which	PRON
cord-018764-02l423mk	89	27	they	they	PRON
cord-018764-02l423mk	89	28	have	have	AUX
cord-018764-02l423mk	89	29	been	be	AUX
cord-018764-02l423mk	89	30	sought	seek	VERB
cord-018764-02l423mk	89	31	.	.	PUNCT
cord-018764-02l423mk	90	1	some	some	DET
cord-018764-02l423mk	90	2	cytokine	cytokine	NOUN
cord-018764-02l423mk	90	3	increased	increase	VERB
cord-018764-02l423mk	90	4	,	,	PUNCT
cord-018764-02l423mk	90	5	and	and	CCONJ
cord-018764-02l423mk	90	6	consequences	consequence	NOUN
cord-018764-02l423mk	90	7	are	be	AUX
cord-018764-02l423mk	90	8	shown	show	VERB
cord-018764-02l423mk	90	9	in	in	ADP
cord-018764-02l423mk	90	10	table	table	NOUN
cord-018764-02l423mk	90	11	2	2	NUM
cord-018764-02l423mk	90	12	.	.	PUNCT
cord-018764-02l423mk	91	1	when	when	SCONJ
cord-018764-02l423mk	91	2	rtnf	rtnf	PROPN
cord-018764-02l423mk	91	3	was	be	AUX
cord-018764-02l423mk	91	4	under	under	ADP
cord-018764-02l423mk	91	5	trial	trial	NOUN
cord-018764-02l423mk	91	6	in	in	ADP
cord-018764-02l423mk	91	7	volunteers	volunteer	NOUN
cord-018764-02l423mk	91	8	as	as	ADP
cord-018764-02l423mk	91	9	an	an	DET
cord-018764-02l423mk	91	10	anti	anti	ADJ
cord-018764-02l423mk	91	11	-	-	ADJ
cord-018764-02l423mk	91	12	tumour	tumour	ADJ
cord-018764-02l423mk	91	13	agent	agent	NOUN
cord-018764-02l423mk	91	14	[	[	PUNCT
cord-018764-02l423mk	91	15	49	49	NUM
cord-018764-02l423mk	91	16	,	,	PUNCT
cord-018764-02l423mk	91	17	50	50	NUM
cord-018764-02l423mk	91	18	]	]	PUNCT
cord-018764-02l423mk	91	19	nearly	nearly	ADV
cord-018764-02l423mk	91	20	20	20	NUM
cord-018764-02l423mk	91	21	years	year	NOUN
cord-018764-02l423mk	91	22	ago	ago	ADV
cord-018764-02l423mk	91	23	,	,	PUNCT
cord-018764-02l423mk	91	24	virtually	virtually	ADV
cord-018764-02l423mk	91	25	all	all	PRON
cord-018764-02l423mk	91	26	of	of	ADP
cord-018764-02l423mk	91	27	the	the	DET
cord-018764-02l423mk	91	28	symptoms	symptom	NOUN
cord-018764-02l423mk	91	29	and	and	CCONJ
cord-018764-02l423mk	91	30	signs	sign	NOUN
cord-018764-02l423mk	91	31	they	they	PRON
cord-018764-02l423mk	91	32	share	share	VERB
cord-018764-02l423mk	91	33	were	be	AUX
cord-018764-02l423mk	91	34	reproduced	reproduce	VERB
cord-018764-02l423mk	91	35	as	as	ADP
cord-018764-02l423mk	91	36	side	side	NOUN
cord-018764-02l423mk	91	37	effects	effect	NOUN
cord-018764-02l423mk	91	38	.	.	PUNCT
cord-018764-02l423mk	92	1	this	this	PRON
cord-018764-02l423mk	92	2	includes	include	VERB
cord-018764-02l423mk	92	3	headache	headache	NOUN
cord-018764-02l423mk	92	4	,	,	PUNCT
cord-018764-02l423mk	92	5	fever	fever	NOUN
cord-018764-02l423mk	92	6	and	and	CCONJ
cord-018764-02l423mk	92	7	rigours	rigour	NOUN
cord-018764-02l423mk	92	8	,	,	PUNCT
cord-018764-02l423mk	92	9	nausea	nausea	NOUN
cord-018764-02l423mk	92	10	and	and	CCONJ
cord-018764-02l423mk	92	11	vomiting	vomiting	NOUN
cord-018764-02l423mk	92	12	,	,	PUNCT
cord-018764-02l423mk	92	13	diarrhoea	diarrhoea	NOUN
cord-018764-02l423mk	92	14	,	,	PUNCT
cord-018764-02l423mk	92	15	anorexia	anorexia	NOUN
cord-018764-02l423mk	92	16	,	,	PUNCT
cord-018764-02l423mk	92	17	myalgia	myalgia	PROPN
cord-018764-02l423mk	92	18	,	,	PUNCT
cord-018764-02l423mk	92	19	thrombocytopaenia	thrombocytopaenia	PROPN
cord-018764-02l423mk	92	20	,	,	PUNCT
cord-018764-02l423mk	92	21	immunosuppression	immunosuppression	NOUN
cord-018764-02l423mk	92	22	,	,	PUNCT
cord-018764-02l423mk	92	23	and	and	CCONJ
cord-018764-02l423mk	92	24	central	central	ADJ
cord-018764-02l423mk	92	25	nervous	nervous	ADJ
cord-018764-02l423mk	92	26	system	system	NOUN
cord-018764-02l423mk	92	27	manifestations	manifestation	NOUN
cord-018764-02l423mk	92	28	,	,	PUNCT
cord-018764-02l423mk	92	29	all	all	PRON
cord-018764-02l423mk	92	30	of	of	ADP
cord-018764-02l423mk	92	31	which	which	PRON
cord-018764-02l423mk	92	32	have	have	AUX
cord-018764-02l423mk	92	33	been	be	AUX
cord-018764-02l423mk	92	34	shown	show	VERB
cord-018764-02l423mk	92	35	to	to	PART
cord-018764-02l423mk	92	36	be	be	AUX
cord-018764-02l423mk	92	37	caused	cause	VERB
cord-018764-02l423mk	92	38	by	by	ADP
cord-018764-02l423mk	92	39	a	a	DET
cord-018764-02l423mk	92	40	mechanism	mechanism	NOUN
cord-018764-02l423mk	92	41	involving	involve	VERB
cord-018764-02l423mk	92	42	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	92	43	cytokines	cytokine	NOUN
cord-018764-02l423mk	92	44	.	.	PUNCT
cord-018764-02l423mk	93	1	the	the	DET
cord-018764-02l423mk	93	2	rate	rate	NOUN
cord-018764-02l423mk	93	3	,	,	PUNCT
cord-018764-02l423mk	93	4	timing	timing	NOUN
cord-018764-02l423mk	93	5	and	and	CCONJ
cord-018764-02l423mk	93	6	intensity	intensity	NOUN
cord-018764-02l423mk	93	7	of	of	ADP
cord-018764-02l423mk	93	8	cytokine	cytokine	NOUN
cord-018764-02l423mk	93	9	release	release	NOUN
cord-018764-02l423mk	93	10	vary	vary	VERB
cord-018764-02l423mk	93	11	in	in	ADP
cord-018764-02l423mk	93	12	different	different	ADJ
cord-018764-02l423mk	93	13	disease	disease	NOUN
cord-018764-02l423mk	93	14	states	state	NOUN
cord-018764-02l423mk	93	15	,	,	PUNCT
cord-018764-02l423mk	93	16	and	and	CCONJ
cord-018764-02l423mk	93	17	provide	provide	VERB
cord-018764-02l423mk	93	18	them	they	PRON
cord-018764-02l423mk	93	19	with	with	ADP
cord-018764-02l423mk	93	20	somewhat	somewhat	ADV
cord-018764-02l423mk	93	21	individual	individual	ADJ
cord-018764-02l423mk	93	22	clinical	clinical	ADJ
cord-018764-02l423mk	93	23	pictures	picture	NOUN
cord-018764-02l423mk	93	24	,	,	PUNCT
cord-018764-02l423mk	93	25	but	but	CCONJ
cord-018764-02l423mk	93	26	the	the	DET
cord-018764-02l423mk	93	27	fundamentals	fundamental	NOUN
cord-018764-02l423mk	93	28	remain	remain	VERB
cord-018764-02l423mk	93	29	.	.	PUNCT
cord-018764-02l423mk	94	1	nevertheless	nevertheless	ADV
cord-018764-02l423mk	94	2	,	,	PUNCT
cord-018764-02l423mk	94	3	the	the	DET
cord-018764-02l423mk	94	4	clinical	clinical	ADJ
cord-018764-02l423mk	94	5	patterns	pattern	NOUN
cord-018764-02l423mk	94	6	generated	generate	VERB
cord-018764-02l423mk	94	7	are	be	AUX
cord-018764-02l423mk	94	8	remarkably	remarkably	ADV
cord-018764-02l423mk	94	9	close	close	ADJ
cord-018764-02l423mk	94	10	,	,	PUNCT
cord-018764-02l423mk	94	11	in	in	ADP
cord-018764-02l423mk	94	12	that	that	PRON
cord-018764-02l423mk	94	13	,	,	PUNCT
cord-018764-02l423mk	94	14	at	at	ADP
cord-018764-02l423mk	94	15	least	least	ADJ
cord-018764-02l423mk	94	16	in	in	ADP
cord-018764-02l423mk	94	17	some	some	DET
cord-018764-02l423mk	94	18	populations	population	NOUN
cord-018764-02l423mk	94	19	,	,	PUNCT
cord-018764-02l423mk	94	20	clinical	clinical	ADJ
cord-018764-02l423mk	94	21	features	feature	NOUN
cord-018764-02l423mk	94	22	can	can	AUX
cord-018764-02l423mk	94	23	not	not	PART
cord-018764-02l423mk	94	24	predict	predict	VERB
cord-018764-02l423mk	94	25	a	a	DET
cord-018764-02l423mk	94	26	diagnosis	diagnosis	NOUN
cord-018764-02l423mk	94	27	of	of	ADP
cord-018764-02l423mk	94	28	malaria	malaria	NOUN
cord-018764-02l423mk	94	29	from	from	ADP
cord-018764-02l423mk	94	30	other	other	ADJ
cord-018764-02l423mk	94	31	causes	cause	NOUN
cord-018764-02l423mk	94	32	of	of	ADP
cord-018764-02l423mk	94	33	fever	fever	NOUN
cord-018764-02l423mk	94	34	[	[	PUNCT
cord-018764-02l423mk	94	35	51	51	NUM
cord-018764-02l423mk	94	36	]	]	PUNCT
cord-018764-02l423mk	94	37	.	.	PUNCT
cord-018764-02l423mk	95	1	mature	mature	ADJ
cord-018764-02l423mk	95	2	erythrocytic	erythrocytic	ADJ
cord-018764-02l423mk	95	3	forms	form	NOUN
cord-018764-02l423mk	95	4	of	of	ADP
cord-018764-02l423mk	95	5	p.	p.	PROPN
cord-018764-02l423mk	95	6	falciparum	falciparum	NOUN
cord-018764-02l423mk	95	7	are	be	AUX
cord-018764-02l423mk	95	8	not	not	PART
cord-018764-02l423mk	95	9	seen	see	VERB
cord-018764-02l423mk	95	10	in	in	ADP
cord-018764-02l423mk	95	11	peripheral	peripheral	ADJ
cord-018764-02l423mk	95	12	blood	blood	NOUN
cord-018764-02l423mk	95	13	smears	smear	NOUN
cord-018764-02l423mk	95	14	,	,	PUNCT
cord-018764-02l423mk	95	15	and	and	CCONJ
cord-018764-02l423mk	95	16	cause	cause	VERB
cord-018764-02l423mk	95	17	the	the	DET
cord-018764-02l423mk	95	18	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	95	19	they	they	PRON
cord-018764-02l423mk	95	20	inhabit	inhabit	VERB
cord-018764-02l423mk	95	21	to	to	PART
cord-018764-02l423mk	95	22	adhere	adhere	VERB
cord-018764-02l423mk	95	23	to	to	ADP
cord-018764-02l423mk	95	24	the	the	DET
cord-018764-02l423mk	95	25	walls	wall	NOUN
cord-018764-02l423mk	95	26	of	of	ADP
cord-018764-02l423mk	95	27	venules	venule	NOUN
cord-018764-02l423mk	95	28	and	and	CCONJ
cord-018764-02l423mk	95	29	capillaries	capillary	NOUN
cord-018764-02l423mk	95	30	.	.	PUNCT
cord-018764-02l423mk	96	1	from	from	ADP
cord-018764-02l423mk	96	2	this	this	DET
cord-018764-02l423mk	96	3	observation	observation	NOUN
cord-018764-02l423mk	96	4	arose	arise	VERB
cord-018764-02l423mk	96	5	the	the	DET
cord-018764-02l423mk	96	6	widely	widely	ADV
cord-018764-02l423mk	96	7	held	hold	VERB
cord-018764-02l423mk	96	8	view	view	NOUN
cord-018764-02l423mk	96	9	that	that	SCONJ
cord-018764-02l423mk	96	10	much	much	ADJ
cord-018764-02l423mk	96	11	of	of	ADP
cord-018764-02l423mk	96	12	the	the	DET
cord-018764-02l423mk	96	13	pathology	pathology	NOUN
cord-018764-02l423mk	96	14	following	follow	VERB
cord-018764-02l423mk	96	15	malarial	malarial	ADJ
cord-018764-02l423mk	96	16	infection	infection	NOUN
cord-018764-02l423mk	96	17	is	be	AUX
cord-018764-02l423mk	96	18	explained	explain	VERB
cord-018764-02l423mk	96	19	through	through	ADP
cord-018764-02l423mk	96	20	parasite	parasite	ADJ
cord-018764-02l423mk	96	21	sequestration	sequestration	NOUN
cord-018764-02l423mk	96	22	causing	cause	VERB
cord-018764-02l423mk	96	23	impairment	impairment	NOUN
cord-018764-02l423mk	96	24	of	of	ADP
cord-018764-02l423mk	96	25	microvascular	microvascular	ADJ
cord-018764-02l423mk	96	26	flow	flow	NOUN
cord-018764-02l423mk	96	27	.	.	PUNCT
cord-018764-02l423mk	97	1	sequestration	sequestration	NOUN
cord-018764-02l423mk	97	2	certainly	certainly	ADV
cord-018764-02l423mk	97	3	occurs	occur	VERB
cord-018764-02l423mk	97	4	,	,	PUNCT
cord-018764-02l423mk	97	5	since	since	SCONJ
cord-018764-02l423mk	97	6	the	the	DET
cord-018764-02l423mk	97	7	life	life	NOUN
cord-018764-02l423mk	97	8	cycle	cycle	NOUN
cord-018764-02l423mk	97	9	dictates	dictate	VERB
cord-018764-02l423mk	97	10	this	this	PRON
cord-018764-02l423mk	97	11	.	.	PUNCT
cord-018764-02l423mk	98	1	however	however	ADV
cord-018764-02l423mk	98	2	,	,	PUNCT
cord-018764-02l423mk	98	3	whether	whether	SCONJ
cord-018764-02l423mk	98	4	the	the	DET
cord-018764-02l423mk	98	5	temporal	temporal	ADJ
cord-018764-02l423mk	98	6	and	and	CCONJ
cord-018764-02l423mk	98	7	anatomical	anatomical	ADJ
cord-018764-02l423mk	98	8	patterns	pattern	NOUN
cord-018764-02l423mk	98	9	of	of	ADP
cord-018764-02l423mk	98	10	sequestration	sequestration	NOUN
cord-018764-02l423mk	98	11	are	be	AUX
cord-018764-02l423mk	98	12	the	the	DET
cord-018764-02l423mk	98	13	same	same	ADJ
cord-018764-02l423mk	98	14	in	in	ADP
cord-018764-02l423mk	98	15	both	both	DET
cord-018764-02l423mk	98	16	individuals	individual	NOUN
cord-018764-02l423mk	98	17	with	with	ADP
cord-018764-02l423mk	98	18	fatal	fatal	ADJ
cord-018764-02l423mk	98	19	disease	disease	NOUN
cord-018764-02l423mk	98	20	and	and	CCONJ
cord-018764-02l423mk	98	21	in	in	ADP
cord-018764-02l423mk	98	22	parasite	parasite	ADJ
cord-018764-02l423mk	98	23	tolerant	tolerant	ADJ
cord-018764-02l423mk	98	24	individuals	individual	NOUN
cord-018764-02l423mk	98	25	has	have	AUX
cord-018764-02l423mk	98	26	not	not	PART
cord-018764-02l423mk	98	27	been	be	AUX
cord-018764-02l423mk	98	28	ascertained	ascertain	VERB
cord-018764-02l423mk	98	29	.	.	PUNCT
cord-018764-02l423mk	99	1	consequently	consequently	ADV
cord-018764-02l423mk	99	2	,	,	PUNCT
cord-018764-02l423mk	99	3	whether	whether	SCONJ
cord-018764-02l423mk	99	4	sequestration	sequestration	NOUN
cord-018764-02l423mk	99	5	is	be	AUX
cord-018764-02l423mk	99	6	the	the	DET
cord-018764-02l423mk	99	7	principal	principal	ADJ
cord-018764-02l423mk	99	8	instigator	instigator	NOUN
cord-018764-02l423mk	99	9	of	of	ADP
cord-018764-02l423mk	99	10	local	local	ADJ
cord-018764-02l423mk	99	11	pathology	pathology	NOUN
cord-018764-02l423mk	99	12	,	,	PUNCT
cord-018764-02l423mk	99	13	or	or	CCONJ
cord-018764-02l423mk	99	14	whether	whether	SCONJ
cord-018764-02l423mk	99	15	sequestration	sequestration	NOUN
cord-018764-02l423mk	99	16	is	be	AUX
cord-018764-02l423mk	99	17	an	an	DET
cord-018764-02l423mk	99	18	associated	associated	ADJ
cord-018764-02l423mk	99	19	feature	feature	NOUN
cord-018764-02l423mk	99	20	of	of	ADP
cord-018764-02l423mk	99	21	all	all	DET
cord-018764-02l423mk	99	22	malarial	malarial	ADJ
cord-018764-02l423mk	99	23	infections	infection	NOUN
cord-018764-02l423mk	99	24	with	with	ADP
cord-018764-02l423mk	99	25	local	local	ADJ
cord-018764-02l423mk	99	26	pathology	pathology	NOUN
cord-018764-02l423mk	99	27	determined	determine	VERB
cord-018764-02l423mk	99	28	by	by	ADP
cord-018764-02l423mk	99	29	other	other	ADJ
cord-018764-02l423mk	99	30	factors	factor	NOUN
cord-018764-02l423mk	99	31	in	in	ADP
cord-018764-02l423mk	99	32	the	the	DET
cord-018764-02l423mk	99	33	host	host	NOUN
cord-018764-02l423mk	99	34	response	response	NOUN
cord-018764-02l423mk	99	35	to	to	ADP
cord-018764-02l423mk	99	36	the	the	DET
cord-018764-02l423mk	99	37	infection	infection	NOUN
cord-018764-02l423mk	99	38	,	,	PUNCT
cord-018764-02l423mk	99	39	e.g.	e.g.	ADV
cord-018764-02l423mk	99	40	a	a	DET
cord-018764-02l423mk	99	41	local	local	ADJ
cord-018764-02l423mk	99	42	imbalance	imbalance	NOUN
cord-018764-02l423mk	99	43	of	of	ADP
cord-018764-02l423mk	99	44	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	99	45	mediators	mediator	NOUN
cord-018764-02l423mk	99	46	,	,	PUNCT
cord-018764-02l423mk	99	47	has	have	AUX
cord-018764-02l423mk	99	48	not	not	PART
cord-018764-02l423mk	99	49	been	be	AUX
cord-018764-02l423mk	99	50	fully	fully	ADV
cord-018764-02l423mk	99	51	elucidated	elucidate	VERB
cord-018764-02l423mk	99	52	.	.	PUNCT
cord-018764-02l423mk	100	1	erythrocyte	erythrocyte	NOUN
cord-018764-02l423mk	100	2	cyto	cyto	NOUN
cord-018764-02l423mk	100	3	-	-	PUNCT
cord-018764-02l423mk	100	4	adherence	adherence	NOUN
cord-018764-02l423mk	100	5	(	(	PUNCT
cord-018764-02l423mk	100	6	irrespective	irrespective	ADV
cord-018764-02l423mk	100	7	of	of	ADP
cord-018764-02l423mk	100	8	whether	whether	SCONJ
cord-018764-02l423mk	100	9	this	this	DET
cord-018764-02l423mk	100	10	adhesive	adhesive	ADJ
cord-018764-02l423mk	100	11	process	process	NOUN
cord-018764-02l423mk	100	12	is	be	AUX
cord-018764-02l423mk	100	13	directly	directly	ADV
cord-018764-02l423mk	100	14	or	or	CCONJ
cord-018764-02l423mk	100	15	indirectly	indirectly	ADV
cord-018764-02l423mk	100	16	due	due	ADP
cord-018764-02l423mk	100	17	to	to	ADP
cord-018764-02l423mk	100	18	parasite	parasite	ADJ
cord-018764-02l423mk	100	19	sequestration	sequestration	NOUN
cord-018764-02l423mk	100	20	)	)	PUNCT
cord-018764-02l423mk	100	21	has	have	AUX
cord-018764-02l423mk	100	22	repeatedly	repeatedly	ADV
cord-018764-02l423mk	100	23	been	be	AUX
cord-018764-02l423mk	100	24	shown	show	VERB
cord-018764-02l423mk	100	25	to	to	PART
cord-018764-02l423mk	100	26	be	be	AUX
cord-018764-02l423mk	100	27	mediated	mediate	VERB
cord-018764-02l423mk	100	28	through	through	ADP
cord-018764-02l423mk	100	29	a	a	DET
cord-018764-02l423mk	100	30	series	series	NOUN
cord-018764-02l423mk	100	31	of	of	ADP
cord-018764-02l423mk	100	32	host	host	NOUN
cord-018764-02l423mk	100	33	-	-	PUNCT
cord-018764-02l423mk	100	34	derived	derive	VERB
cord-018764-02l423mk	100	35	ligands	ligand	NOUN
cord-018764-02l423mk	100	36	.	.	PUNCT
cord-018764-02l423mk	101	1	cd36	cd36	PROPN
cord-018764-02l423mk	101	2	and	and	CCONJ
cord-018764-02l423mk	101	3	thrombospondin	thrombospondin	PROPN
cord-018764-02l423mk	101	4	were	be	AUX
cord-018764-02l423mk	101	5	the	the	DET
cord-018764-02l423mk	101	6	first	first	ADJ
cord-018764-02l423mk	101	7	described	describe	VERB
cord-018764-02l423mk	101	8	endothelial	endothelial	ADJ
cord-018764-02l423mk	101	9	receptors	receptor	NOUN
cord-018764-02l423mk	101	10	that	that	PRON
cord-018764-02l423mk	101	11	bound	bind	VERB
cord-018764-02l423mk	101	12	infected	infected	ADJ
cord-018764-02l423mk	101	13	red	red	ADJ
cord-018764-02l423mk	101	14	blood	blood	NOUN
cord-018764-02l423mk	101	15	cells	cell	NOUN
cord-018764-02l423mk	101	16	(	(	PUNCT
cord-018764-02l423mk	101	17	rbcs	rbc	NOUN
cord-018764-02l423mk	101	18	)	)	PUNCT
cord-018764-02l423mk	101	19	[	[	PUNCT
cord-018764-02l423mk	101	20	52	52	NUM
cord-018764-02l423mk	101	21	,	,	PUNCT
cord-018764-02l423mk	101	22	53	53	NUM
cord-018764-02l423mk	101	23	]	]	PUNCT
cord-018764-02l423mk	101	24	,	,	PUNCT
cord-018764-02l423mk	101	25	with	with	ADP
cord-018764-02l423mk	101	26	most	most	ADJ
cord-018764-02l423mk	101	27	studied	study	VERB
cord-018764-02l423mk	101	28	wild	wild	ADJ
cord-018764-02l423mk	101	29	parasite	parasite	NOUN
cord-018764-02l423mk	101	30	isolates	isolate	NOUN
cord-018764-02l423mk	101	31	demonstrating	demonstrate	VERB
cord-018764-02l423mk	101	32	adhesion	adhesion	NOUN
cord-018764-02l423mk	101	33	to	to	ADP
cord-018764-02l423mk	101	34	cd36	cd36	PROPN
cord-018764-02l423mk	101	35	[	[	X
cord-018764-02l423mk	101	36	54	54	NUM
cord-018764-02l423mk	101	37	]	]	PUNCT
cord-018764-02l423mk	101	38	.	.	PUNCT
cord-018764-02l423mk	102	1	more	more	ADV
cord-018764-02l423mk	102	2	recently	recently	ADV
cord-018764-02l423mk	102	3	,	,	PUNCT
cord-018764-02l423mk	102	4	it	it	PRON
cord-018764-02l423mk	102	5	has	have	AUX
cord-018764-02l423mk	102	6	been	be	AUX
cord-018764-02l423mk	102	7	shown	show	VERB
cord-018764-02l423mk	102	8	that	that	SCONJ
cord-018764-02l423mk	102	9	p.	p.	NOUN
cord-018764-02l423mk	102	10	falciparum	falciparum	NOUN
cord-018764-02l423mk	102	11	also	also	ADV
cord-018764-02l423mk	102	12	interacts	interact	VERB
cord-018764-02l423mk	102	13	with	with	ADP
cord-018764-02l423mk	102	14	other	other	ADJ
cord-018764-02l423mk	102	15	host	host	NOUN
cord-018764-02l423mk	102	16	adhesion	adhesion	NOUN
cord-018764-02l423mk	102	17	receptors	receptor	NOUN
cord-018764-02l423mk	102	18	,	,	PUNCT
cord-018764-02l423mk	102	19	i.e.	i.e.	X
cord-018764-02l423mk	102	20	intercellular	intercellular	ADJ
cord-018764-02l423mk	102	21	adhesion	adhesion	NOUN
cord-018764-02l423mk	102	22	molecule-1	molecule-1	NOUN
cord-018764-02l423mk	102	23	(	(	PUNCT
cord-018764-02l423mk	102	24	icam-1	icam-1	NUM
cord-018764-02l423mk	102	25	cd54	cd54	PROPN
cord-018764-02l423mk	102	26	)	)	PUNCT
cord-018764-02l423mk	102	27	,	,	PUNCT
cord-018764-02l423mk	102	28	vascular	vascular	ADJ
cord-018764-02l423mk	102	29	cell	cell	NOUN
cord-018764-02l423mk	102	30	adhesion	adhesion	NOUN
cord-018764-02l423mk	102	31	molecule-1	molecule-1	PROPN
cord-018764-02l423mk	102	32	(	(	PUNCT
cord-018764-02l423mk	102	33	vcam-1	vcam-1	NUM
cord-018764-02l423mk	102	34	cd106	cd106	NOUN
cord-018764-02l423mk	102	35	)	)	PUNCT
cord-018764-02l423mk	102	36	and	and	CCONJ
cord-018764-02l423mk	102	37	e	e	NOUN
cord-018764-02l423mk	102	38	-	-	ADJ
cord-018764-02l423mk	102	39	selectin	selectin	ADJ
cord-018764-02l423mk	102	40	[	[	X
cord-018764-02l423mk	102	41	55	55	NUM
cord-018764-02l423mk	102	42	,	,	PUNCT
cord-018764-02l423mk	102	43	56	56	NUM
cord-018764-02l423mk	102	44	]	]	PUNCT
cord-018764-02l423mk	102	45	.	.	PUNCT
cord-018764-02l423mk	103	1	certain	certain	ADJ
cord-018764-02l423mk	103	2	adhesive	adhesive	ADJ
cord-018764-02l423mk	103	3	phenotypes	phenotype	NOUN
cord-018764-02l423mk	103	4	,	,	PUNCT
cord-018764-02l423mk	103	5	such	such	ADJ
cord-018764-02l423mk	103	6	as	as	ADP
cord-018764-02l423mk	103	7	rosetting	rosette	VERB
cord-018764-02l423mk	103	8	(	(	PUNCT
cord-018764-02l423mk	103	9	the	the	DET
cord-018764-02l423mk	103	10	spontaneous	spontaneous	ADJ
cord-018764-02l423mk	103	11	tethering	tethering	NOUN
cord-018764-02l423mk	103	12	of	of	ADP
cord-018764-02l423mk	103	13	infected	infect	VERB
cord-018764-02l423mk	103	14	and	and	CCONJ
cord-018764-02l423mk	103	15	non	non	ADJ
cord-018764-02l423mk	103	16	-	-	ADJ
cord-018764-02l423mk	103	17	infected	infected	ADJ
cord-018764-02l423mk	103	18	rbcs	rbc	NOUN
cord-018764-02l423mk	103	19	)	)	PUNCT
cord-018764-02l423mk	103	20	and	and	CCONJ
cord-018764-02l423mk	103	21	clumping	clumping	NOUN
cord-018764-02l423mk	103	22	(	(	PUNCT
cord-018764-02l423mk	103	23	tethering	tethering	NOUN
cord-018764-02l423mk	103	24	of	of	ADP
cord-018764-02l423mk	103	25	infected	infect	VERB
cord-018764-02l423mk	103	26	rbcs	rbc	NOUN
cord-018764-02l423mk	103	27	through	through	ADP
cord-018764-02l423mk	103	28	platelets	platelet	NOUN
cord-018764-02l423mk	103	29	)	)	PUNCT
cord-018764-02l423mk	103	30	have	have	AUX
cord-018764-02l423mk	103	31	been	be	AUX
cord-018764-02l423mk	103	32	preferentially	preferentially	ADV
cord-018764-02l423mk	103	33	associated	associate	VERB
cord-018764-02l423mk	103	34	with	with	ADP
cord-018764-02l423mk	103	35	severe	severe	ADJ
cord-018764-02l423mk	103	36	malarial	malarial	ADJ
cord-018764-02l423mk	103	37	disease	disease	NOUN
cord-018764-02l423mk	103	38	[	[	X
cord-018764-02l423mk	103	39	57	57	NUM
cord-018764-02l423mk	103	40	,	,	PUNCT
cord-018764-02l423mk	103	41	58	58	NUM
cord-018764-02l423mk	103	42	]	]	PUNCT
cord-018764-02l423mk	103	43	.	.	PUNCT
cord-018764-02l423mk	104	1	cd36	cd36	PROPN
cord-018764-02l423mk	104	2	is	be	AUX
cord-018764-02l423mk	104	3	involved	involve	VERB
cord-018764-02l423mk	104	4	in	in	ADP
cord-018764-02l423mk	104	5	both	both	DET
cord-018764-02l423mk	104	6	mechanisms	mechanism	NOUN
cord-018764-02l423mk	104	7	of	of	ADP
cord-018764-02l423mk	104	8	adhesion	adhesion	NOUN
cord-018764-02l423mk	104	9	,	,	PUNCT
cord-018764-02l423mk	104	10	and	and	CCONJ
cord-018764-02l423mk	104	11	a	a	DET
cord-018764-02l423mk	104	12	non	non	ADJ
cord-018764-02l423mk	104	13	-	-	ADJ
cord-018764-02l423mk	104	14	sense	sense	ADJ
cord-018764-02l423mk	104	15	mutation	mutation	NOUN
cord-018764-02l423mk	104	16	in	in	ADP
cord-018764-02l423mk	104	17	the	the	DET
cord-018764-02l423mk	104	18	gene	gene	NOUN
cord-018764-02l423mk	104	19	encoding	encoding	NOUN
cord-018764-02l423mk	104	20	for	for	ADP
cord-018764-02l423mk	104	21	cd36	cd36	PROPN
cord-018764-02l423mk	104	22	has	have	AUX
cord-018764-02l423mk	104	23	also	also	ADV
cord-018764-02l423mk	104	24	been	be	AUX
cord-018764-02l423mk	104	25	associated	associate	VERB
cord-018764-02l423mk	104	26	with	with	ADP
cord-018764-02l423mk	104	27	protection	protection	NOUN
cord-018764-02l423mk	104	28	from	from	ADP
cord-018764-02l423mk	104	29	severe	severe	ADJ
cord-018764-02l423mk	104	30	malaria	malaria	NOUN
cord-018764-02l423mk	105	1	[	[	PUNCT
cord-018764-02l423mk	105	2	59	59	NUM
cord-018764-02l423mk	105	3	]	]	PUNCT
cord-018764-02l423mk	105	4	.	.	PUNCT
cord-018764-02l423mk	106	1	polymorphisms	polymorphism	NOUN
cord-018764-02l423mk	106	2	in	in	ADP
cord-018764-02l423mk	106	3	the	the	DET
cord-018764-02l423mk	106	4	gene	gene	NOUN
cord-018764-02l423mk	106	5	encoding	encode	VERB
cord-018764-02l423mk	106	6	icam-1	icam-1	PROPN
cord-018764-02l423mk	106	7	have	have	AUX
cord-018764-02l423mk	106	8	also	also	ADV
cord-018764-02l423mk	106	9	been	be	AUX
cord-018764-02l423mk	106	10	associated	associate	VERB
cord-018764-02l423mk	106	11	with	with	ADP
cord-018764-02l423mk	106	12	susceptibility	susceptibility	NOUN
cord-018764-02l423mk	106	13	to	to	ADP
cord-018764-02l423mk	106	14	severe	severe	ADJ
cord-018764-02l423mk	106	15	disease	disease	NOUN
cord-018764-02l423mk	106	16	[	[	X
cord-018764-02l423mk	106	17	27	27	NUM
cord-018764-02l423mk	106	18	]	]	PUNCT
cord-018764-02l423mk	106	19	.	.	PUNCT
cord-018764-02l423mk	107	1	furthermore	furthermore	ADV
cord-018764-02l423mk	107	2	,	,	PUNCT
cord-018764-02l423mk	107	3	icam-1	icam-1	NUM
cord-018764-02l423mk	107	4	,	,	PUNCT
cord-018764-02l423mk	107	5	together	together	ADV
cord-018764-02l423mk	107	6	with	with	ADP
cord-018764-02l423mk	107	7	vcam	vcam	NOUN
cord-018764-02l423mk	107	8	and	and	CCONJ
cord-018764-02l423mk	107	9	e	e	NOUN
cord-018764-02l423mk	107	10	-	-	PROPN
cord-018764-02l423mk	107	11	selectin	selectin	ADJ
cord-018764-02l423mk	107	12	,	,	PUNCT
cord-018764-02l423mk	107	13	are	be	AUX
cord-018764-02l423mk	107	14	up	up	ADV
cord-018764-02l423mk	107	15	-	-	PUNCT
cord-018764-02l423mk	107	16	regulated	regulate	VERB
cord-018764-02l423mk	107	17	by	by	ADP
cord-018764-02l423mk	107	18	tnf	tnf	PROPN
cord-018764-02l423mk	107	19	,	,	PUNCT
cord-018764-02l423mk	107	20	with	with	ADP
cord-018764-02l423mk	107	21	circulating	circulate	VERB
cord-018764-02l423mk	107	22	levels	level	NOUN
cord-018764-02l423mk	107	23	of	of	ADP
cord-018764-02l423mk	107	24	these	these	DET
cord-018764-02l423mk	107	25	ligands	ligand	NOUN
cord-018764-02l423mk	107	26	shown	show	VERB
cord-018764-02l423mk	107	27	to	to	PART
cord-018764-02l423mk	107	28	be	be	AUX
cord-018764-02l423mk	107	29	increased	increase	VERB
cord-018764-02l423mk	107	30	in	in	ADP
cord-018764-02l423mk	107	31	severe	severe	ADJ
cord-018764-02l423mk	107	32	malaria	malaria	NOUN
cord-018764-02l423mk	107	33	compared	compare	VERB
cord-018764-02l423mk	107	34	to	to	ADP
cord-018764-02l423mk	107	35	uncomplicated	uncomplicated	ADJ
cord-018764-02l423mk	107	36	infection	infection	NOUN
cord-018764-02l423mk	107	37	[	[	X
cord-018764-02l423mk	107	38	60	60	NUM
cord-018764-02l423mk	107	39	]	]	PUNCT
cord-018764-02l423mk	107	40	.	.	PUNCT
cord-018764-02l423mk	108	1	sequestration	sequestration	NOUN
cord-018764-02l423mk	108	2	during	during	ADP
cord-018764-02l423mk	108	3	falciparum	falciparum	PROPN
cord-018764-02l423mk	108	4	malaria	malaria	NOUN
cord-018764-02l423mk	108	5	appears	appear	VERB
cord-018764-02l423mk	108	6	to	to	PART
cord-018764-02l423mk	108	7	be	be	AUX
cord-018764-02l423mk	108	8	concentrated	concentrate	VERB
cord-018764-02l423mk	108	9	in	in	ADP
cord-018764-02l423mk	108	10	the	the	DET
cord-018764-02l423mk	108	11	brain	brain	NOUN
cord-018764-02l423mk	108	12	and	and	CCONJ
cord-018764-02l423mk	108	13	placenta	placenta	PROPN
cord-018764-02l423mk	108	14	.	.	PUNCT
cord-018764-02l423mk	109	1	there	there	PRON
cord-018764-02l423mk	109	2	is	be	VERB
cord-018764-02l423mk	109	3	some	some	DET
cord-018764-02l423mk	109	4	evidence	evidence	NOUN
cord-018764-02l423mk	109	5	to	to	PART
cord-018764-02l423mk	109	6	suggest	suggest	VERB
cord-018764-02l423mk	109	7	that	that	SCONJ
cord-018764-02l423mk	109	8	the	the	DET
cord-018764-02l423mk	109	9	propensity	propensity	NOUN
cord-018764-02l423mk	109	10	of	of	ADP
cord-018764-02l423mk	109	11	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	109	12	cytokines	cytokine	NOUN
cord-018764-02l423mk	109	13	to	to	ADP
cord-018764-02l423mk	109	14	up	up	ADP
cord-018764-02l423mk	109	15	-	-	PUNCT
cord-018764-02l423mk	109	16	regulate	regulate	VERB
cord-018764-02l423mk	109	17	cell	cell	NOUN
cord-018764-02l423mk	109	18	adhesion	adhesion	NOUN
cord-018764-02l423mk	109	19	molecules	molecule	NOUN
cord-018764-02l423mk	109	20	,	,	PUNCT
cord-018764-02l423mk	109	21	secondary	secondary	ADJ
cord-018764-02l423mk	109	22	to	to	ADP
cord-018764-02l423mk	109	23	local	local	ADJ
cord-018764-02l423mk	109	24	variation	variation	NOUN
cord-018764-02l423mk	109	25	in	in	ADP
cord-018764-02l423mk	109	26	the	the	DET
cord-018764-02l423mk	109	27	density	density	NOUN
cord-018764-02l423mk	109	28	of	of	ADP
cord-018764-02l423mk	109	29	thrombomodulin	thrombomodulin	NOUN
cord-018764-02l423mk	109	30	,	,	PUNCT
cord-018764-02l423mk	109	31	is	be	AUX
cord-018764-02l423mk	109	32	potentially	potentially	ADV
cord-018764-02l423mk	109	33	higher	high	ADJ
cord-018764-02l423mk	109	34	in	in	ADP
cord-018764-02l423mk	109	35	the	the	DET
cord-018764-02l423mk	109	36	microvasculature	microvasculature	NOUN
cord-018764-02l423mk	109	37	of	of	ADP
cord-018764-02l423mk	109	38	the	the	DET
cord-018764-02l423mk	109	39	brain	brain	NOUN
cord-018764-02l423mk	109	40	and	and	CCONJ
cord-018764-02l423mk	109	41	placenta	placenta	NOUN
cord-018764-02l423mk	109	42	compared	compare	VERB
cord-018764-02l423mk	109	43	to	to	ADP
cord-018764-02l423mk	109	44	other	other	ADJ
cord-018764-02l423mk	109	45	tissues	tissue	NOUN
cord-018764-02l423mk	109	46	.	.	PUNCT
cord-018764-02l423mk	110	1	as	as	SCONJ
cord-018764-02l423mk	110	2	reviewed	review	VERB
cord-018764-02l423mk	110	3	[	[	X
cord-018764-02l423mk	110	4	61	61	NUM
cord-018764-02l423mk	110	5	]	]	PUNCT
cord-018764-02l423mk	110	6	,	,	PUNCT
cord-018764-02l423mk	110	7	tnf	tnf	PROPN
cord-018764-02l423mk	110	8	and	and	CCONJ
cord-018764-02l423mk	110	9	il-1	il-1	ADP
cord-018764-02l423mk	110	10	increase	increase	VERB
cord-018764-02l423mk	110	11	tissue	tissue	NOUN
cord-018764-02l423mk	110	12	factor	factor	NOUN
cord-018764-02l423mk	110	13	expression	expression	NOUN
cord-018764-02l423mk	110	14	on	on	ADP
cord-018764-02l423mk	110	15	endothelial	endothelial	ADJ
cord-018764-02l423mk	110	16	cells	cell	NOUN
cord-018764-02l423mk	110	17	,	,	PUNCT
cord-018764-02l423mk	110	18	thereby	thereby	ADV
cord-018764-02l423mk	110	19	initiating	initiate	VERB
cord-018764-02l423mk	110	20	pathways	pathway	NOUN
cord-018764-02l423mk	110	21	that	that	PRON
cord-018764-02l423mk	110	22	generate	generate	VERB
cord-018764-02l423mk	110	23	thrombin	thrombin	NOUN
cord-018764-02l423mk	110	24	[	[	X
cord-018764-02l423mk	110	25	62	62	NUM
cord-018764-02l423mk	110	26	]	]	PUNCT
cord-018764-02l423mk	110	27	.	.	PUNCT
cord-018764-02l423mk	111	1	when	when	SCONJ
cord-018764-02l423mk	111	2	thrombin	thrombin	NOUN
cord-018764-02l423mk	111	3	binds	bind	VERB
cord-018764-02l423mk	111	4	to	to	ADP
cord-018764-02l423mk	111	5	thrombomodulin	thrombomodulin	NOUN
cord-018764-02l423mk	111	6	on	on	ADP
cord-018764-02l423mk	111	7	the	the	DET
cord-018764-02l423mk	111	8	endothelial	endothelial	ADJ
cord-018764-02l423mk	111	9	cell	cell	NOUN
cord-018764-02l423mk	111	10	surface	surface	NOUN
cord-018764-02l423mk	111	11	,	,	PUNCT
cord-018764-02l423mk	111	12	protein	protein	NOUN
cord-018764-02l423mk	111	13	c	c	PROPN
cord-018764-02l423mk	111	14	is	be	AUX
cord-018764-02l423mk	111	15	activated	activate	VERB
cord-018764-02l423mk	111	16	,	,	PUNCT
cord-018764-02l423mk	111	17	which	which	PRON
cord-018764-02l423mk	111	18	in	in	ADP
cord-018764-02l423mk	111	19	turn	turn	NOUN
cord-018764-02l423mk	111	20	can	can	AUX
cord-018764-02l423mk	111	21	lead	lead	VERB
cord-018764-02l423mk	111	22	to	to	ADP
cord-018764-02l423mk	111	23	further	further	ADJ
cord-018764-02l423mk	111	24	downstream	downstream	ADJ
cord-018764-02l423mk	111	25	activation	activation	NOUN
cord-018764-02l423mk	111	26	of	of	ADP
cord-018764-02l423mk	111	27	the	the	DET
cord-018764-02l423mk	111	28	coagulation	coagulation	NOUN
cord-018764-02l423mk	111	29	cascade	cascade	NOUN
cord-018764-02l423mk	111	30	.	.	PUNCT
cord-018764-02l423mk	112	1	therefore	therefore	ADV
cord-018764-02l423mk	112	2	vasculature	vasculature	VERB
cord-018764-02l423mk	112	3	with	with	ADP
cord-018764-02l423mk	112	4	lowest	low	ADJ
cord-018764-02l423mk	112	5	thrombomodulin	thrombomodulin	NOUN
cord-018764-02l423mk	112	6	densities	density	NOUN
cord-018764-02l423mk	112	7	on	on	ADP
cord-018764-02l423mk	112	8	the	the	DET
cord-018764-02l423mk	112	9	endothelial	endothelial	ADJ
cord-018764-02l423mk	112	10	cell	cell	NOUN
cord-018764-02l423mk	112	11	surface	surface	NOUN
cord-018764-02l423mk	112	12	(	(	PUNCT
cord-018764-02l423mk	112	13	brain	brain	NOUN
cord-018764-02l423mk	112	14	least	least	ADJ
cord-018764-02l423mk	112	15	,	,	PUNCT
cord-018764-02l423mk	112	16	placenta	placenta	PROPN
cord-018764-02l423mk	112	17	next	next	ADV
cord-018764-02l423mk	112	18	least	least	ADJ
cord-018764-02l423mk	112	19	,	,	PUNCT
cord-018764-02l423mk	112	20	and	and	CCONJ
cord-018764-02l423mk	112	21	other	other	ADJ
cord-018764-02l423mk	112	22	organs	organ	NOUN
cord-018764-02l423mk	112	23	more	more	ADV
cord-018764-02l423mk	112	24	[	[	SYM
cord-018764-02l423mk	112	25	63	63	NUM
cord-018764-02l423mk	112	26	]	]	PUNCT
cord-018764-02l423mk	112	27	)	)	PUNCT
cord-018764-02l423mk	112	28	will	will	AUX
cord-018764-02l423mk	112	29	have	have	VERB
cord-018764-02l423mk	112	30	more	more	ADJ
cord-018764-02l423mk	112	31	unbound	unbound	ADJ
cord-018764-02l423mk	112	32	thrombin	thrombin	NOUN
cord-018764-02l423mk	112	33	available	available	ADJ
cord-018764-02l423mk	112	34	for	for	ADP
cord-018764-02l423mk	112	35	its	its	PRON
cord-018764-02l423mk	112	36	other	other	ADJ
cord-018764-02l423mk	112	37	functions	function	NOUN
cord-018764-02l423mk	112	38	on	on	ADP
cord-018764-02l423mk	112	39	activated	activate	VERB
cord-018764-02l423mk	112	40	endothelium	endothelium	NOUN
cord-018764-02l423mk	112	41	.	.	PUNCT
cord-018764-02l423mk	113	1	these	these	DET
cord-018764-02l423mk	113	2	other	other	ADJ
cord-018764-02l423mk	113	3	functions	function	NOUN
cord-018764-02l423mk	113	4	include	include	VERB
cord-018764-02l423mk	113	5	up	up	ADP
cord-018764-02l423mk	113	6	-	-	PUNCT
cord-018764-02l423mk	113	7	regulation	regulation	NOUN
cord-018764-02l423mk	113	8	of	of	ADP
cord-018764-02l423mk	113	9	adhesion	adhesion	NOUN
cord-018764-02l423mk	113	10	molecules	molecule	NOUN
cord-018764-02l423mk	113	11	such	such	ADJ
cord-018764-02l423mk	113	12	as	as	ADP
cord-018764-02l423mk	113	13	selectins	selectin	NOUN
cord-018764-02l423mk	113	14	,	,	PUNCT
cord-018764-02l423mk	113	15	icam-1	icam-1	NUM
cord-018764-02l423mk	113	16	,	,	PUNCT
cord-018764-02l423mk	113	17	vcam-1	vcam-1	NOUN
cord-018764-02l423mk	114	1	[	[	PUNCT
cord-018764-02l423mk	114	2	64	64	NUM
cord-018764-02l423mk	114	3	]	]	PUNCT
cord-018764-02l423mk	114	4	and	and	CCONJ
cord-018764-02l423mk	114	5	monocyte	monocyte	NOUN
cord-018764-02l423mk	114	6	chemotactic	chemotactic	NOUN
cord-018764-02l423mk	114	7	protein-1	protein-1	NOUN
cord-018764-02l423mk	114	8	(	(	PUNCT
cord-018764-02l423mk	114	9	mcp-1	mcp-1	X
cord-018764-02l423mk	114	10	)	)	PUNCT
cord-018764-02l423mk	114	11	[	[	X
cord-018764-02l423mk	114	12	65	65	NUM
cord-018764-02l423mk	114	13	]	]	PUNCT
cord-018764-02l423mk	114	14	.	.	PUNCT
cord-018764-02l423mk	115	1	therefore	therefore	ADV
cord-018764-02l423mk	115	2	,	,	PUNCT
cord-018764-02l423mk	115	3	up	up	ADV
cord-018764-02l423mk	115	4	-	-	PUNCT
cord-018764-02l423mk	115	5	regulation	regulation	NOUN
cord-018764-02l423mk	115	6	of	of	ADP
cord-018764-02l423mk	115	7	adhesion	adhesion	NOUN
cord-018764-02l423mk	115	8	molecules	molecule	NOUN
cord-018764-02l423mk	115	9	within	within	ADP
cord-018764-02l423mk	115	10	the	the	DET
cord-018764-02l423mk	115	11	cerebral	cerebral	ADJ
cord-018764-02l423mk	115	12	vessels	vessel	NOUN
cord-018764-02l423mk	115	13	may	may	AUX
cord-018764-02l423mk	115	14	occur	occur	VERB
cord-018764-02l423mk	115	15	as	as	ADP
cord-018764-02l423mk	115	16	a	a	DET
cord-018764-02l423mk	115	17	local	local	ADJ
cord-018764-02l423mk	115	18	endothelial	endothelial	ADJ
cord-018764-02l423mk	115	19	response	response	NOUN
cord-018764-02l423mk	115	20	to	to	ADP
cord-018764-02l423mk	115	21	systemic	systemic	ADJ
cord-018764-02l423mk	115	22	inflammation	inflammation	NOUN
cord-018764-02l423mk	115	23	and	and	CCONJ
cord-018764-02l423mk	115	24	may	may	AUX
cord-018764-02l423mk	115	25	not	not	PART
cord-018764-02l423mk	115	26	necessarily	necessarily	ADV
cord-018764-02l423mk	115	27	be	be	AUX
cord-018764-02l423mk	115	28	precipitated	precipitate	VERB
cord-018764-02l423mk	115	29	by	by	ADP
cord-018764-02l423mk	115	30	parasite	parasite	ADJ
cord-018764-02l423mk	115	31	sequestration	sequestration	NOUN
cord-018764-02l423mk	115	32	.	.	PUNCT
cord-018764-02l423mk	116	1	anaemia	anaemia	NOUN
cord-018764-02l423mk	116	2	is	be	AUX
cord-018764-02l423mk	116	3	another	another	DET
cord-018764-02l423mk	116	4	obvious	obvious	ADJ
cord-018764-02l423mk	116	5	way	way	NOUN
cord-018764-02l423mk	116	6	in	in	ADP
cord-018764-02l423mk	116	7	which	which	PRON
cord-018764-02l423mk	116	8	too	too	ADV
cord-018764-02l423mk	116	9	little	little	ADJ
cord-018764-02l423mk	116	10	oxygen	oxygen	NOUN
cord-018764-02l423mk	116	11	reaches	reach	VERB
cord-018764-02l423mk	116	12	cells	cell	NOUN
cord-018764-02l423mk	116	13	,	,	PUNCT
cord-018764-02l423mk	116	14	and	and	CCONJ
cord-018764-02l423mk	116	15	thus	thus	ADV
cord-018764-02l423mk	116	16	their	their	PRON
cord-018764-02l423mk	116	17	mitochondria	mitochondria	NOUN
cord-018764-02l423mk	116	18	[	[	X
cord-018764-02l423mk	116	19	66	66	NUM
cord-018764-02l423mk	116	20	]	]	PUNCT
cord-018764-02l423mk	116	21	.	.	PUNCT
cord-018764-02l423mk	117	1	as	as	SCONJ
cord-018764-02l423mk	117	2	recently	recently	ADV
cord-018764-02l423mk	117	3	reviewed	review	VERB
cord-018764-02l423mk	117	4	[	[	X
cord-018764-02l423mk	117	5	67	67	NUM
cord-018764-02l423mk	117	6	]	]	PUNCT
cord-018764-02l423mk	117	7	,	,	PUNCT
cord-018764-02l423mk	117	8	critical	critical	ADJ
cord-018764-02l423mk	117	9	illness	illness	NOUN
cord-018764-02l423mk	117	10	associated	associate	VERB
cord-018764-02l423mk	117	11	with	with	ADP
cord-018764-02l423mk	117	12	an	an	DET
cord-018764-02l423mk	117	13	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	117	14	response	response	NOUN
cord-018764-02l423mk	117	15	invariably	invariably	ADV
cord-018764-02l423mk	117	16	causes	cause	VERB
cord-018764-02l423mk	117	17	multifactorial	multifactorial	ADJ
cord-018764-02l423mk	117	18	anaemia	anaemia	NOUN
cord-018764-02l423mk	117	19	.	.	PUNCT
cord-018764-02l423mk	118	1	obviously	obviously	ADV
cord-018764-02l423mk	118	2	a	a	DET
cord-018764-02l423mk	118	3	high	high	ADJ
cord-018764-02l423mk	118	4	parasite	parasite	NOUN
cord-018764-02l423mk	118	5	load	load	NOUN
cord-018764-02l423mk	118	6	in	in	ADP
cord-018764-02l423mk	118	7	malaria	malaria	NOUN
cord-018764-02l423mk	118	8	indicates	indicate	VERB
cord-018764-02l423mk	118	9	that	that	SCONJ
cord-018764-02l423mk	118	10	the	the	DET
cord-018764-02l423mk	118	11	infected	infect	VERB
cord-018764-02l423mk	118	12	rbcs	rbc	NOUN
cord-018764-02l423mk	118	13	will	will	AUX
cord-018764-02l423mk	118	14	soon	soon	ADV
cord-018764-02l423mk	118	15	burst	burst	VERB
cord-018764-02l423mk	118	16	when	when	SCONJ
cord-018764-02l423mk	118	17	the	the	DET
cord-018764-02l423mk	118	18	next	next	ADJ
cord-018764-02l423mk	118	19	generation	generation	NOUN
cord-018764-02l423mk	118	20	of	of	ADP
cord-018764-02l423mk	118	21	erythrocytic	erythrocytic	ADJ
cord-018764-02l423mk	118	22	forms	form	NOUN
cord-018764-02l423mk	118	23	escapes	escape	VERB
cord-018764-02l423mk	118	24	,	,	PUNCT
cord-018764-02l423mk	118	25	but	but	CCONJ
cord-018764-02l423mk	118	26	anaemia	anaemia	NOUN
cord-018764-02l423mk	118	27	does	do	AUX
cord-018764-02l423mk	118	28	not	not	PART
cord-018764-02l423mk	118	29	correlate	correlate	VERB
cord-018764-02l423mk	118	30	with	with	ADP
cord-018764-02l423mk	118	31	parasitaemia	parasitaemia	NOUN
cord-018764-02l423mk	118	32	,	,	PUNCT
cord-018764-02l423mk	118	33	and	and	CCONJ
cord-018764-02l423mk	118	34	sometimes	sometimes	ADV
cord-018764-02l423mk	118	35	is	be	AUX
cord-018764-02l423mk	118	36	extreme	extreme	ADJ
cord-018764-02l423mk	118	37	when	when	SCONJ
cord-018764-02l423mk	118	38	very	very	ADV
cord-018764-02l423mk	118	39	few	few	ADJ
cord-018764-02l423mk	118	40	parasites	parasite	NOUN
cord-018764-02l423mk	118	41	are	be	AUX
cord-018764-02l423mk	118	42	,	,	PUNCT
cord-018764-02l423mk	118	43	or	or	CCONJ
cord-018764-02l423mk	118	44	have	have	AUX
cord-018764-02l423mk	118	45	been	be	AUX
cord-018764-02l423mk	118	46	,	,	PUNCT
cord-018764-02l423mk	118	47	present	present	ADJ
cord-018764-02l423mk	118	48	.	.	PUNCT
cord-018764-02l423mk	119	1	the	the	DET
cord-018764-02l423mk	119	2	severe	severe	ADJ
cord-018764-02l423mk	119	3	anaemia	anaemia	NOUN
cord-018764-02l423mk	119	4	in	in	ADP
cord-018764-02l423mk	119	5	transgenic	transgenic	ADJ
cord-018764-02l423mk	119	6	mice	mouse	NOUN
cord-018764-02l423mk	119	7	expressing	express	VERB
cord-018764-02l423mk	119	8	human	human	ADJ
cord-018764-02l423mk	119	9	tnf	tnf	PROPN
cord-018764-02l423mk	120	1	[	[	PUNCT
cord-018764-02l423mk	120	2	68	68	NUM
cord-018764-02l423mk	120	3	]	]	PUNCT
cord-018764-02l423mk	120	4	incriminates	incriminate	NOUN
cord-018764-02l423mk	120	5	the	the	DET
cord-018764-02l423mk	120	6	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	120	7	response	response	NOUN
cord-018764-02l423mk	120	8	itself	itself	PRON
cord-018764-02l423mk	120	9	,	,	PUNCT
cord-018764-02l423mk	120	10	so	so	CCONJ
cord-018764-02l423mk	120	11	anaemia	anaemia	NOUN
cord-018764-02l423mk	120	12	and	and	CCONJ
cord-018764-02l423mk	120	13	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	120	14	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	120	15	(	(	PUNCT
cord-018764-02l423mk	120	16	see	see	VERB
cord-018764-02l423mk	120	17	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	120	18	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	120	19	section	section	NOUN
cord-018764-02l423mk	120	20	below	below	ADV
cord-018764-02l423mk	120	21	)	)	PUNCT
cord-018764-02l423mk	120	22	,	,	PUNCT
cord-018764-02l423mk	120	23	both	both	DET
cord-018764-02l423mk	120	24	consequences	consequence	NOUN
cord-018764-02l423mk	120	25	of	of	ADP
cord-018764-02l423mk	120	26	systemic	systemic	ADJ
cord-018764-02l423mk	120	27	inflammation	inflammation	NOUN
cord-018764-02l423mk	120	28	,	,	PUNCT
cord-018764-02l423mk	120	29	can	can	AUX
cord-018764-02l423mk	120	30	be	be	AUX
cord-018764-02l423mk	120	31	expected	expect	VERB
cord-018764-02l423mk	120	32	to	to	PART
cord-018764-02l423mk	120	33	coexist	coexist	VERB
cord-018764-02l423mk	120	34	,	,	PUNCT
cord-018764-02l423mk	120	35	and	and	CCONJ
cord-018764-02l423mk	120	36	both	both	PRON
cord-018764-02l423mk	120	37	contribute	contribute	VERB
cord-018764-02l423mk	120	38	to	to	ADP
cord-018764-02l423mk	120	39	total	total	ADJ
cord-018764-02l423mk	120	40	energy	energy	NOUN
cord-018764-02l423mk	120	41	depletion	depletion	NOUN
cord-018764-02l423mk	120	42	.	.	PUNCT
cord-018764-02l423mk	121	1	the	the	DET
cord-018764-02l423mk	121	2	lifespan	lifespan	NOUN
cord-018764-02l423mk	121	3	of	of	ADP
cord-018764-02l423mk	121	4	an	an	DET
cord-018764-02l423mk	121	5	rbc	rbc	PROPN
cord-018764-02l423mk	121	6	is	be	AUX
cord-018764-02l423mk	121	7	,	,	PUNCT
cord-018764-02l423mk	121	8	in	in	ADP
cord-018764-02l423mk	121	9	part	part	NOUN
cord-018764-02l423mk	121	10	,	,	PUNCT
cord-018764-02l423mk	121	11	limited	limit	VERB
cord-018764-02l423mk	121	12	by	by	ADP
cord-018764-02l423mk	121	13	how	how	SCONJ
cord-018764-02l423mk	121	14	long	long	ADV
cord-018764-02l423mk	121	15	it	it	PRON
cord-018764-02l423mk	121	16	can	can	AUX
cord-018764-02l423mk	121	17	remain	remain	VERB
cord-018764-02l423mk	121	18	flexible	flexible	ADJ
cord-018764-02l423mk	121	19	enough	enough	ADV
cord-018764-02l423mk	121	20	to	to	PART
cord-018764-02l423mk	121	21	squeeze	squeeze	VERB
cord-018764-02l423mk	121	22	through	through	ADP
cord-018764-02l423mk	121	23	fenestrations	fenestration	NOUN
cord-018764-02l423mk	121	24	in	in	ADP
cord-018764-02l423mk	121	25	specialised	specialised	ADJ
cord-018764-02l423mk	121	26	vessels	vessel	NOUN
cord-018764-02l423mk	121	27	in	in	ADP
cord-018764-02l423mk	121	28	the	the	DET
cord-018764-02l423mk	121	29	red	red	ADJ
cord-018764-02l423mk	121	30	pulp	pulp	NOUN
cord-018764-02l423mk	121	31	of	of	ADP
cord-018764-02l423mk	121	32	the	the	DET
cord-018764-02l423mk	121	33	spleen	spleen	NOUN
cord-018764-02l423mk	121	34	,	,	PUNCT
cord-018764-02l423mk	121	35	and	and	CCONJ
cord-018764-02l423mk	121	36	thus	thus	ADV
cord-018764-02l423mk	121	37	avoid	avoid	VERB
cord-018764-02l423mk	121	38	phagocytosis	phagocytosis	NOUN
cord-018764-02l423mk	121	39	by	by	ADP
cord-018764-02l423mk	121	40	adjacent	adjacent	ADJ
cord-018764-02l423mk	121	41	macrophages	macrophage	NOUN
cord-018764-02l423mk	121	42	.	.	PUNCT
cord-018764-02l423mk	122	1	normally	normally	ADV
cord-018764-02l423mk	122	2	this	this	DET
cord-018764-02l423mk	122	3	loss	loss	NOUN
cord-018764-02l423mk	122	4	is	be	AUX
cord-018764-02l423mk	122	5	balanced	balance	VERB
cord-018764-02l423mk	122	6	by	by	ADP
cord-018764-02l423mk	122	7	erythropoiesis	erythropoiesis	NOUN
cord-018764-02l423mk	122	8	,	,	PUNCT
cord-018764-02l423mk	122	9	and	and	CCONJ
cord-018764-02l423mk	122	10	haematocrit	haematocrit	NOUN
cord-018764-02l423mk	122	11	remains	remain	VERB
cord-018764-02l423mk	122	12	normal	normal	ADJ
cord-018764-02l423mk	122	13	.	.	PUNCT
cord-018764-02l423mk	123	1	if	if	SCONJ
cord-018764-02l423mk	123	2	rbcs	rbc	NOUN
cord-018764-02l423mk	123	3	develop	develop	VERB
cord-018764-02l423mk	123	4	a	a	DET
cord-018764-02l423mk	123	5	premature	premature	ADJ
cord-018764-02l423mk	123	6	loss	loss	NOUN
cord-018764-02l423mk	123	7	of	of	ADP
cord-018764-02l423mk	123	8	deformability	deformability	NOUN
cord-018764-02l423mk	123	9	they	they	PRON
cord-018764-02l423mk	123	10	are	be	AUX
cord-018764-02l423mk	123	11	removed	remove	VERB
cord-018764-02l423mk	123	12	from	from	ADP
cord-018764-02l423mk	123	13	the	the	DET
cord-018764-02l423mk	123	14	circulation	circulation	NOUN
cord-018764-02l423mk	123	15	earlier	early	ADV
cord-018764-02l423mk	123	16	.	.	PUNCT
cord-018764-02l423mk	124	1	this	this	DET
cord-018764-02l423mk	124	2	loss	loss	NOUN
cord-018764-02l423mk	124	3	of	of	ADP
cord-018764-02l423mk	124	4	deformability	deformability	NOUN
cord-018764-02l423mk	124	5	happens	happen	VERB
cord-018764-02l423mk	124	6	to	to	ADP
cord-018764-02l423mk	124	7	both	both	CCONJ
cord-018764-02l423mk	124	8	infected	infect	VERB
cord-018764-02l423mk	124	9	and	and	CCONJ
cord-018764-02l423mk	124	10	non	non	ADJ
cord-018764-02l423mk	124	11	-	-	ADJ
cord-018764-02l423mk	124	12	infected	infected	ADJ
cord-018764-02l423mk	124	13	red	red	ADJ
cord-018764-02l423mk	124	14	cells	cell	NOUN
cord-018764-02l423mk	124	15	in	in	ADP
cord-018764-02l423mk	124	16	malaria	malaria	NOUN
cord-018764-02l423mk	124	17	,	,	PUNCT
cord-018764-02l423mk	124	18	whether	whether	SCONJ
cord-018764-02l423mk	124	19	caused	cause	VERB
cord-018764-02l423mk	124	20	by	by	ADP
cord-018764-02l423mk	124	21	p.	p.	PROPN
cord-018764-02l423mk	124	22	vivax	vivax	PROPN
cord-018764-02l423mk	124	23	or	or	CCONJ
cord-018764-02l423mk	124	24	p.	p.	PROPN
cord-018764-02l423mk	124	25	falciparum	falciparum	NOUN
cord-018764-02l423mk	124	26	.	.	PUNCT
cord-018764-02l423mk	125	1	under	under	ADP
cord-018764-02l423mk	125	2	physiological	physiological	ADJ
cord-018764-02l423mk	125	3	conditions	condition	NOUN
cord-018764-02l423mk	125	4	,	,	PUNCT
cord-018764-02l423mk	125	5	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	125	6	(	(	PUNCT
cord-018764-02l423mk	125	7	and	and	CCONJ
cord-018764-02l423mk	125	8	other	other	ADJ
cord-018764-02l423mk	125	9	cells	cell	NOUN
cord-018764-02l423mk	125	10	)	)	PUNCT
cord-018764-02l423mk	125	11	control	control	VERB
cord-018764-02l423mk	125	12	the	the	DET
cord-018764-02l423mk	125	13	passive	passive	ADJ
cord-018764-02l423mk	125	14	influx	influx	NOUN
cord-018764-02l423mk	125	15	of	of	ADP
cord-018764-02l423mk	125	16	osmotic	osmotic	ADJ
cord-018764-02l423mk	125	17	active	active	ADJ
cord-018764-02l423mk	125	18	solutes	solute	NOUN
cord-018764-02l423mk	125	19	(	(	PUNCT
cord-018764-02l423mk	125	20	especially	especially	ADV
cord-018764-02l423mk	125	21	na	na	X
cord-018764-02l423mk	125	22	+	+	NUM
cord-018764-02l423mk	125	23	)	)	PUNCT
cord-018764-02l423mk	125	24	via	via	ADP
cord-018764-02l423mk	125	25	an	an	DET
cord-018764-02l423mk	125	26	active	active	ADJ
cord-018764-02l423mk	125	27	,	,	PUNCT
cord-018764-02l423mk	125	28	energy	energy	NOUN
cord-018764-02l423mk	125	29	-	-	PUNCT
cord-018764-02l423mk	125	30	dependent	dependent	ADJ
cord-018764-02l423mk	125	31	elimination	elimination	NOUN
cord-018764-02l423mk	125	32	of	of	ADP
cord-018764-02l423mk	125	33	these	these	DET
cord-018764-02l423mk	125	34	solutes	solute	NOUN
cord-018764-02l423mk	125	35	using	use	VERB
cord-018764-02l423mk	125	36	na	na	ADP
cord-018764-02l423mk	125	37	+	+	CCONJ
cord-018764-02l423mk	125	38	/k	/k	PUNCT
cord-018764-02l423mk	126	1	+	+	INTJ
cord-018764-02l423mk	126	2	-atpase	-atpase	NOUN
cord-018764-02l423mk	126	3	.	.	PUNCT
cord-018764-02l423mk	127	1	this	this	PRON
cord-018764-02l423mk	127	2	prevents	prevent	VERB
cord-018764-02l423mk	127	3	intracellular	intracellular	ADJ
cord-018764-02l423mk	127	4	accumulation	accumulation	NOUN
cord-018764-02l423mk	127	5	of	of	ADP
cord-018764-02l423mk	127	6	osmotically	osmotically	ADV
cord-018764-02l423mk	127	7	active	active	ADJ
cord-018764-02l423mk	127	8	solutes	solute	NOUN
cord-018764-02l423mk	127	9	,	,	PUNCT
cord-018764-02l423mk	127	10	preventing	prevent	VERB
cord-018764-02l423mk	127	11	a	a	DET
cord-018764-02l423mk	127	12	subsequent	subsequent	ADJ
cord-018764-02l423mk	127	13	influx	influx	NOUN
cord-018764-02l423mk	127	14	of	of	ADP
cord-018764-02l423mk	127	15	water	water	NOUN
cord-018764-02l423mk	127	16	,	,	PUNCT
cord-018764-02l423mk	127	17	cell	cell	NOUN
cord-018764-02l423mk	127	18	swelling	swelling	NOUN
cord-018764-02l423mk	127	19	and	and	CCONJ
cord-018764-02l423mk	127	20	loss	loss	NOUN
cord-018764-02l423mk	127	21	of	of	ADP
cord-018764-02l423mk	127	22	cell	cell	NOUN
cord-018764-02l423mk	127	23	integrity	integrity	NOUN
cord-018764-02l423mk	127	24	.	.	PUNCT
cord-018764-02l423mk	128	1	during	during	ADP
cord-018764-02l423mk	128	2	human	human	NOUN
cord-018764-02l423mk	128	3	[	[	X
cord-018764-02l423mk	128	4	69	69	NUM
cord-018764-02l423mk	128	5	]	]	PUNCT
cord-018764-02l423mk	128	6	and	and	CCONJ
cord-018764-02l423mk	128	7	monkey	monkey	NOUN
cord-018764-02l423mk	129	1	[	[	X
cord-018764-02l423mk	129	2	70	70	NUM
cord-018764-02l423mk	129	3	]	]	PUNCT
cord-018764-02l423mk	129	4	malaria	malaria	NOUN
cord-018764-02l423mk	129	5	infection	infection	NOUN
cord-018764-02l423mk	129	6	,	,	PUNCT
cord-018764-02l423mk	129	7	intracellular	intracellular	ADJ
cord-018764-02l423mk	129	8	na	na	ADP
cord-018764-02l423mk	129	9	+	+	CCONJ
cord-018764-02l423mk	129	10	accumulates	accumulate	VERB
cord-018764-02l423mk	129	11	within	within	ADP
cord-018764-02l423mk	129	12	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	129	13	(	(	PUNCT
cord-018764-02l423mk	129	14	both	both	PRON
cord-018764-02l423mk	129	15	parasitised	parasitise	VERB
cord-018764-02l423mk	129	16	and	and	CCONJ
cord-018764-02l423mk	129	17	non	non	ADJ
cord-018764-02l423mk	129	18	-	-	ADJ
cord-018764-02l423mk	129	19	parasitised	parasitise	VERB
cord-018764-02l423mk	129	20	)	)	PUNCT
cord-018764-02l423mk	129	21	implying	imply	VERB
cord-018764-02l423mk	129	22	that	that	SCONJ
cord-018764-02l423mk	129	23	this	this	PRON
cord-018764-02l423mk	129	24	na	na	X
cord-018764-02l423mk	129	25	+	+	X
cord-018764-02l423mk	129	26	/k	/k	PUNCT
cord-018764-02l423mk	130	1	+	+	X
cord-018764-02l423mk	130	2	pump	pump	NOUN
cord-018764-02l423mk	130	3	is	be	AUX
cord-018764-02l423mk	130	4	impaired	impair	VERB
cord-018764-02l423mk	130	5	during	during	ADP
cord-018764-02l423mk	130	6	the	the	DET
cord-018764-02l423mk	130	7	disease	disease	NOUN
cord-018764-02l423mk	130	8	process	process	NOUN
cord-018764-02l423mk	130	9	.	.	PUNCT
cord-018764-02l423mk	131	1	parallel	parallel	ADJ
cord-018764-02l423mk	131	2	changes	change	NOUN
cord-018764-02l423mk	131	3	in	in	ADP
cord-018764-02l423mk	131	4	the	the	DET
cord-018764-02l423mk	131	5	ionic	ionic	ADJ
cord-018764-02l423mk	131	6	content	content	NOUN
cord-018764-02l423mk	131	7	of	of	ADP
cord-018764-02l423mk	131	8	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	131	9	have	have	AUX
cord-018764-02l423mk	131	10	been	be	AUX
cord-018764-02l423mk	131	11	documented	document	VERB
cord-018764-02l423mk	131	12	in	in	ADP
cord-018764-02l423mk	131	13	a	a	DET
cord-018764-02l423mk	131	14	sepsis	sepsis	NOUN
cord-018764-02l423mk	131	15	model	model	NOUN
cord-018764-02l423mk	131	16	of	of	ADP
cord-018764-02l423mk	131	17	infection	infection	NOUN
cord-018764-02l423mk	131	18	[	[	PUNCT
cord-018764-02l423mk	131	19	71	71	NUM
cord-018764-02l423mk	131	20	]	]	PUNCT
cord-018764-02l423mk	131	21	.	.	PUNCT
cord-018764-02l423mk	132	1	similarly	similarly	ADV
cord-018764-02l423mk	132	2	,	,	PUNCT
cord-018764-02l423mk	132	3	reduction	reduction	NOUN
cord-018764-02l423mk	132	4	in	in	ADP
cord-018764-02l423mk	132	5	erythrocyte	erythrocyte	NOUN
cord-018764-02l423mk	132	6	deformability	deformability	NOUN
cord-018764-02l423mk	132	7	was	be	AUX
cord-018764-02l423mk	132	8	shown	show	VERB
cord-018764-02l423mk	132	9	to	to	PART
cord-018764-02l423mk	132	10	be	be	AUX
cord-018764-02l423mk	132	11	associated	associate	VERB
cord-018764-02l423mk	132	12	with	with	ADP
cord-018764-02l423mk	132	13	increased	increase	VERB
cord-018764-02l423mk	132	14	no	no	NOUN
cord-018764-02l423mk	132	15	,	,	PUNCT
cord-018764-02l423mk	132	16	an	an	DET
cord-018764-02l423mk	132	17	inhibitor	inhibitor	NOUN
cord-018764-02l423mk	132	18	of	of	ADP
cord-018764-02l423mk	132	19	this	this	DET
cord-018764-02l423mk	132	20	membrane	membrane	NOUN
cord-018764-02l423mk	132	21	pump	pump	NOUN
cord-018764-02l423mk	132	22	[	[	X
cord-018764-02l423mk	132	23	72	72	NUM
cord-018764-02l423mk	132	24	]	]	PUNCT
cord-018764-02l423mk	132	25	,	,	PUNCT
cord-018764-02l423mk	132	26	in	in	ADP
cord-018764-02l423mk	132	27	another	another	DET
cord-018764-02l423mk	132	28	sepsis	sepsis	NOUN
cord-018764-02l423mk	132	29	model	model	NOUN
cord-018764-02l423mk	132	30	[	[	X
cord-018764-02l423mk	132	31	73	73	NUM
cord-018764-02l423mk	132	32	]	]	PUNCT
cord-018764-02l423mk	132	33	.	.	PUNCT
cord-018764-02l423mk	133	1	since	since	SCONJ
cord-018764-02l423mk	133	2	inhibition	inhibition	NOUN
cord-018764-02l423mk	133	3	of	of	ADP
cord-018764-02l423mk	133	4	the	the	DET
cord-018764-02l423mk	133	5	na	na	NOUN
cord-018764-02l423mk	133	6	+	+	CCONJ
cord-018764-02l423mk	133	7	/k	/k	PUNCT
cord-018764-02l423mk	134	1	+	+	X
cord-018764-02l423mk	134	2	pump	pump	VERB
cord-018764-02l423mk	134	3	in	in	ADV
cord-018764-02l423mk	135	1	vitro	vitro	X
cord-018764-02l423mk	135	2	correlates	correlate	VERB
cord-018764-02l423mk	135	3	with	with	ADP
cord-018764-02l423mk	135	4	both	both	CCONJ
cord-018764-02l423mk	135	5	reduced	reduce	VERB
cord-018764-02l423mk	135	6	red	red	ADJ
cord-018764-02l423mk	135	7	cell	cell	NOUN
cord-018764-02l423mk	135	8	deformability	deformability	NOUN
cord-018764-02l423mk	135	9	and	and	CCONJ
cord-018764-02l423mk	135	10	decreased	decrease	VERB
cord-018764-02l423mk	135	11	red	red	ADJ
cord-018764-02l423mk	135	12	cell	cell	NOUN
cord-018764-02l423mk	135	13	filterability	filterability	NOUN
cord-018764-02l423mk	136	1	[	[	PUNCT
cord-018764-02l423mk	136	2	74	74	NUM
cord-018764-02l423mk	136	3	]	]	PUNCT
cord-018764-02l423mk	136	4	,	,	PUNCT
cord-018764-02l423mk	136	5	any	any	DET
cord-018764-02l423mk	136	6	factor	factor	NOUN
cord-018764-02l423mk	136	7	that	that	PRON
cord-018764-02l423mk	136	8	inhibits	inhibit	VERB
cord-018764-02l423mk	136	9	the	the	DET
cord-018764-02l423mk	136	10	na	na	X
cord-018764-02l423mk	136	11	+	+	X
cord-018764-02l423mk	136	12	/k	/k	PUNCT
cord-018764-02l423mk	137	1	+	+	X
cord-018764-02l423mk	137	2	pump	pump	NOUN
cord-018764-02l423mk	137	3	could	could	AUX
cord-018764-02l423mk	137	4	potentially	potentially	ADV
cord-018764-02l423mk	137	5	worsen	worsen	VERB
cord-018764-02l423mk	137	6	anaemia	anaemia	NOUN
cord-018764-02l423mk	137	7	.	.	PUNCT
cord-018764-02l423mk	138	1	identification	identification	NOUN
cord-018764-02l423mk	138	2	of	of	ADP
cord-018764-02l423mk	138	3	inducible	inducible	VERB
cord-018764-02l423mk	138	4	no	no	DET
cord-018764-02l423mk	138	5	synthase	synthase	NOUN
cord-018764-02l423mk	138	6	(	(	PUNCT
cord-018764-02l423mk	138	7	inos	ino	NOUN
cord-018764-02l423mk	138	8	)	)	PUNCT
cord-018764-02l423mk	138	9	activity	activity	NOUN
cord-018764-02l423mk	138	10	,	,	PUNCT
cord-018764-02l423mk	138	11	as	as	ADP
cord-018764-02l423mk	138	12	one	one	NUM
cord-018764-02l423mk	138	13	factor	factor	NOUN
cord-018764-02l423mk	138	14	influencing	influence	VERB
cord-018764-02l423mk	138	15	red	red	ADJ
cord-018764-02l423mk	138	16	cell	cell	NOUN
cord-018764-02l423mk	138	17	deformability	deformability	NOUN
cord-018764-02l423mk	138	18	,	,	PUNCT
cord-018764-02l423mk	138	19	suggests	suggest	VERB
cord-018764-02l423mk	138	20	that	that	SCONJ
cord-018764-02l423mk	138	21	a	a	DET
cord-018764-02l423mk	138	22	pro	pro	ADJ
cord-018764-02l423mk	138	23	-	-	ADJ
cord-018764-02l423mk	138	24	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	138	25	milieu	milieu	NOUN
cord-018764-02l423mk	138	26	[	[	PUNCT
cord-018764-02l423mk	138	27	75	75	NUM
cord-018764-02l423mk	138	28	]	]	PUNCT
cord-018764-02l423mk	138	29	may	may	AUX
cord-018764-02l423mk	138	30	again	again	ADV
cord-018764-02l423mk	138	31	govern	govern	VERB
cord-018764-02l423mk	138	32	the	the	DET
cord-018764-02l423mk	138	33	reduction	reduction	NOUN
cord-018764-02l423mk	138	34	in	in	ADP
cord-018764-02l423mk	138	35	red	red	ADJ
cord-018764-02l423mk	138	36	cell	cell	NOUN
cord-018764-02l423mk	138	37	deformability	deformability	NOUN
cord-018764-02l423mk	138	38	observed	observe	VERB
cord-018764-02l423mk	138	39	during	during	ADP
cord-018764-02l423mk	138	40	malaria	malaria	NOUN
cord-018764-02l423mk	138	41	infection	infection	NOUN
cord-018764-02l423mk	138	42	.	.	PUNCT
cord-018764-02l423mk	139	1	originally	originally	ADV
cord-018764-02l423mk	139	2	observed	observe	VERB
cord-018764-02l423mk	139	3	in	in	ADP
cord-018764-02l423mk	139	4	uraemic	uraemic	ADJ
cord-018764-02l423mk	139	5	patients	patient	NOUN
cord-018764-02l423mk	139	6	,	,	PUNCT
cord-018764-02l423mk	139	7	poor	poor	ADJ
cord-018764-02l423mk	139	8	red	red	ADJ
cord-018764-02l423mk	139	9	cell	cell	NOUN
cord-018764-02l423mk	139	10	deformability	deformability	NOUN
cord-018764-02l423mk	139	11	was	be	AUX
cord-018764-02l423mk	139	12	recognised	recognise	VERB
cord-018764-02l423mk	139	13	in	in	ADP
cord-018764-02l423mk	139	14	a	a	DET
cord-018764-02l423mk	139	15	small	small	ADJ
cord-018764-02l423mk	139	16	pilot	pilot	NOUN
cord-018764-02l423mk	139	17	study	study	NOUN
cord-018764-02l423mk	139	18	of	of	ADP
cord-018764-02l423mk	139	19	malaria	malaria	NOUN
cord-018764-02l423mk	139	20	patients	patient	NOUN
cord-018764-02l423mk	139	21	in	in	ADP
cord-018764-02l423mk	139	22	1985	1985	NUM
cord-018764-02l423mk	139	23	[	[	X
cord-018764-02l423mk	139	24	76	76	NUM
cord-018764-02l423mk	139	25	]	]	PUNCT
cord-018764-02l423mk	139	26	.	.	PUNCT
cord-018764-02l423mk	140	1	it	it	PRON
cord-018764-02l423mk	140	2	was	be	AUX
cord-018764-02l423mk	140	3	reported	report	VERB
cord-018764-02l423mk	140	4	soon	soon	ADV
cord-018764-02l423mk	140	5	afterwards	afterwards	ADV
cord-018764-02l423mk	140	6	in	in	ADP
cord-018764-02l423mk	140	7	sepsis	sepsis	NOUN
cord-018764-02l423mk	140	8	[	[	X
cord-018764-02l423mk	140	9	77	77	NUM
cord-018764-02l423mk	140	10	,	,	PUNCT
cord-018764-02l423mk	140	11	78	78	NUM
cord-018764-02l423mk	140	12	]	]	PUNCT
cord-018764-02l423mk	140	13	,	,	PUNCT
cord-018764-02l423mk	140	14	and	and	CCONJ
cord-018764-02l423mk	140	15	subsequently	subsequently	ADV
cord-018764-02l423mk	140	16	studied	study	VERB
cord-018764-02l423mk	140	17	in	in	ADP
cord-018764-02l423mk	140	18	falciparum	falciparum	NOUN
cord-018764-02l423mk	140	19	malaria	malaria	NOUN
cord-018764-02l423mk	140	20	with	with	ADP
cord-018764-02l423mk	140	21	a	a	DET
cord-018764-02l423mk	140	22	view	view	NOUN
cord-018764-02l423mk	140	23	to	to	ADP
cord-018764-02l423mk	140	24	understanding	understand	VERB
cord-018764-02l423mk	140	25	both	both	DET
cord-018764-02l423mk	140	26	circulatory	circulatory	ADJ
cord-018764-02l423mk	140	27	obstruction	obstruction	NOUN
cord-018764-02l423mk	140	28	[	[	PUNCT
cord-018764-02l423mk	140	29	79	79	NUM
cord-018764-02l423mk	140	30	]	]	PUNCT
cord-018764-02l423mk	140	31	and	and	CCONJ
cord-018764-02l423mk	140	32	anaemia	anaemia	NOUN
cord-018764-02l423mk	141	1	[	[	PUNCT
cord-018764-02l423mk	141	2	80	80	NUM
cord-018764-02l423mk	141	3	]	]	PUNCT
cord-018764-02l423mk	141	4	.	.	PUNCT
cord-018764-02l423mk	142	1	it	it	PRON
cord-018764-02l423mk	142	2	seems	seem	VERB
cord-018764-02l423mk	142	3	clear	clear	ADJ
cord-018764-02l423mk	142	4	that	that	SCONJ
cord-018764-02l423mk	142	5	a	a	DET
cord-018764-02l423mk	142	6	short	short	ADJ
cord-018764-02l423mk	142	7	life	life	NOUN
cord-018764-02l423mk	142	8	(	(	PUNCT
cord-018764-02l423mk	142	9	poor	poor	ADJ
cord-018764-02l423mk	142	10	deformability	deformability	NOUN
cord-018764-02l423mk	142	11	)	)	PUNCT
cord-018764-02l423mk	142	12	,	,	PUNCT
cord-018764-02l423mk	142	13	and	and	CCONJ
cord-018764-02l423mk	142	14	a	a	DET
cord-018764-02l423mk	142	15	slow	slow	ADJ
cord-018764-02l423mk	142	16	replacement	replacement	NOUN
cord-018764-02l423mk	142	17	rate	rate	NOUN
cord-018764-02l423mk	142	18	(	(	PUNCT
cord-018764-02l423mk	142	19	dyserythropoiesis	dyserythropoiesis	NOUN
cord-018764-02l423mk	142	20	,	,	PUNCT
cord-018764-02l423mk	142	21	below	below	ADV
cord-018764-02l423mk	142	22	)	)	PUNCT
cord-018764-02l423mk	142	23	can	can	AUX
cord-018764-02l423mk	142	24	combine	combine	VERB
cord-018764-02l423mk	142	25	to	to	PART
cord-018764-02l423mk	142	26	cause	cause	VERB
cord-018764-02l423mk	142	27	severe	severe	ADJ
cord-018764-02l423mk	142	28	anaemia	anaemia	NOUN
cord-018764-02l423mk	142	29	in	in	ADP
cord-018764-02l423mk	142	30	various	various	ADJ
cord-018764-02l423mk	142	31	diseases	disease	NOUN
cord-018764-02l423mk	142	32	,	,	PUNCT
cord-018764-02l423mk	142	33	particularly	particularly	ADV
cord-018764-02l423mk	142	34	in	in	ADP
cord-018764-02l423mk	142	35	chronic	chronic	ADJ
cord-018764-02l423mk	142	36	infections	infection	NOUN
cord-018764-02l423mk	142	37	such	such	ADJ
cord-018764-02l423mk	142	38	as	as	ADP
cord-018764-02l423mk	142	39	malaria	malaria	NOUN
cord-018764-02l423mk	142	40	.	.	PUNCT
cord-018764-02l423mk	143	1	when	when	SCONJ
cord-018764-02l423mk	143	2	red	red	ADJ
cord-018764-02l423mk	143	3	cells	cell	NOUN
cord-018764-02l423mk	143	4	have	have	VERB
cord-018764-02l423mk	143	5	a	a	DET
cord-018764-02l423mk	143	6	shortened	shorten	VERB
cord-018764-02l423mk	143	7	lifespan	lifespan	NOUN
cord-018764-02l423mk	143	8	,	,	PUNCT
cord-018764-02l423mk	143	9	e.g.	e.g.	ADV
cord-018764-02l423mk	143	10	secondary	secondary	ADJ
cord-018764-02l423mk	143	11	to	to	ADP
cord-018764-02l423mk	143	12	reduced	reduce	VERB
cord-018764-02l423mk	143	13	erythrocyte	erythrocyte	NOUN
cord-018764-02l423mk	143	14	deformability	deformability	NOUN
cord-018764-02l423mk	143	15	,	,	PUNCT
cord-018764-02l423mk	143	16	replacement	replacement	NOUN
cord-018764-02l423mk	143	17	by	by	ADP
cord-018764-02l423mk	143	18	new	new	ADJ
cord-018764-02l423mk	143	19	recruits	recruit	NOUN
cord-018764-02l423mk	143	20	is	be	AUX
cord-018764-02l423mk	143	21	vital	vital	ADJ
cord-018764-02l423mk	143	22	to	to	PART
cord-018764-02l423mk	143	23	avoid	avoid	VERB
cord-018764-02l423mk	143	24	anaemia	anaemia	NOUN
cord-018764-02l423mk	143	25	.	.	PUNCT
cord-018764-02l423mk	144	1	unfortunately	unfortunately	ADV
cord-018764-02l423mk	144	2	,	,	PUNCT
cord-018764-02l423mk	144	3	the	the	DET
cord-018764-02l423mk	144	4	same	same	ADJ
cord-018764-02l423mk	144	5	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	144	6	cytokines	cytokine	NOUN
cord-018764-02l423mk	144	7	that	that	PRON
cord-018764-02l423mk	144	8	shorten	shorten	ADJ
cord-018764-02l423mk	144	9	lifespan	lifespan	NOUN
cord-018764-02l423mk	144	10	also	also	ADV
cord-018764-02l423mk	144	11	retard	retard	ADJ
cord-018764-02l423mk	144	12	replacement	replacement	NOUN
cord-018764-02l423mk	144	13	.	.	PUNCT
cord-018764-02l423mk	145	1	some	some	DET
cord-018764-02l423mk	145	2	years	year	NOUN
cord-018764-02l423mk	145	3	ago	ago	ADV
cord-018764-02l423mk	145	4	researchers	researcher	NOUN
cord-018764-02l423mk	145	5	began	begin	VERB
cord-018764-02l423mk	145	6	to	to	PART
cord-018764-02l423mk	145	7	stress	stress	VERB
cord-018764-02l423mk	145	8	the	the	DET
cord-018764-02l423mk	145	9	contribution	contribution	NOUN
cord-018764-02l423mk	145	10	of	of	ADP
cord-018764-02l423mk	145	11	bone	bone	NOUN
cord-018764-02l423mk	145	12	marrow	marrow	NOUN
cord-018764-02l423mk	145	13	dyserythropoiesis	dyserythropoiesis	NOUN
cord-018764-02l423mk	145	14	to	to	ADP
cord-018764-02l423mk	145	15	the	the	DET
cord-018764-02l423mk	145	16	anaemia	anaemia	NOUN
cord-018764-02l423mk	145	17	of	of	ADP
cord-018764-02l423mk	145	18	falciparum	falciparum	NOUN
cord-018764-02l423mk	145	19	malaria	malaria	NOUN
cord-018764-02l423mk	145	20	[	[	X
cord-018764-02l423mk	145	21	81	81	NUM
cord-018764-02l423mk	145	22	,	,	PUNCT
cord-018764-02l423mk	145	23	82	82	NUM
cord-018764-02l423mk	145	24	]	]	PUNCT
cord-018764-02l423mk	145	25	.	.	PUNCT
cord-018764-02l423mk	146	1	a	a	DET
cord-018764-02l423mk	146	2	group	group	NOUN
cord-018764-02l423mk	146	3	in	in	ADP
cord-018764-02l423mk	146	4	oxford	oxford	PROPN
cord-018764-02l423mk	146	5	[	[	PUNCT
cord-018764-02l423mk	146	6	83	83	NUM
cord-018764-02l423mk	146	7	]	]	PUNCT
cord-018764-02l423mk	146	8	,	,	PUNCT
cord-018764-02l423mk	146	9	seeking	seek	VERB
cord-018764-02l423mk	146	10	an	an	DET
cord-018764-02l423mk	146	11	explanation	explanation	NOUN
cord-018764-02l423mk	146	12	for	for	ADP
cord-018764-02l423mk	146	13	this	this	DET
cord-018764-02l423mk	146	14	dyserythropoiesis	dyserythropoiesis	NOUN
cord-018764-02l423mk	146	15	through	through	ADP
cord-018764-02l423mk	146	16	an	an	DET
cord-018764-02l423mk	146	17	electron	electron	NOUN
cord-018764-02l423mk	146	18	microscopy	microscopy	NOUN
cord-018764-02l423mk	146	19	study	study	NOUN
cord-018764-02l423mk	146	20	of	of	ADP
cord-018764-02l423mk	146	21	bone	bone	NOUN
cord-018764-02l423mk	146	22	marrow	marrow	NOUN
cord-018764-02l423mk	146	23	,	,	PUNCT
cord-018764-02l423mk	146	24	observed	observe	VERB
cord-018764-02l423mk	146	25	sequestration	sequestration	NOUN
cord-018764-02l423mk	146	26	of	of	ADP
cord-018764-02l423mk	146	27	parasitised	parasitise	VERB
cord-018764-02l423mk	146	28	red	red	ADJ
cord-018764-02l423mk	146	29	cells	cell	NOUN
cord-018764-02l423mk	146	30	and	and	CCONJ
cord-018764-02l423mk	146	31	argued	argue	VERB
cord-018764-02l423mk	146	32	that	that	SCONJ
cord-018764-02l423mk	146	33	this	this	PRON
cord-018764-02l423mk	146	34	caused	cause	VERB
cord-018764-02l423mk	146	35	the	the	DET
cord-018764-02l423mk	146	36	bone	bone	NOUN
cord-018764-02l423mk	146	37	marrow	marrow	NOUN
cord-018764-02l423mk	146	38	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	146	39	in	in	ADP
cord-018764-02l423mk	146	40	falciparum	falciparum	NOUN
cord-018764-02l423mk	146	41	malaria	malaria	NOUN
cord-018764-02l423mk	146	42	by	by	ADP
cord-018764-02l423mk	146	43	restricting	restrict	VERB
cord-018764-02l423mk	146	44	blood	blood	NOUN
cord-018764-02l423mk	146	45	flow	flow	NOUN
cord-018764-02l423mk	146	46	and	and	CCONJ
cord-018764-02l423mk	146	47	thus	thus	ADV
cord-018764-02l423mk	146	48	inducing	induce	VERB
cord-018764-02l423mk	146	49	hypoxic	hypoxic	NOUN
cord-018764-02l423mk	146	50	changes	change	NOUN
cord-018764-02l423mk	146	51	.	.	PUNCT
cord-018764-02l423mk	147	1	this	this	DET
cord-018764-02l423mk	147	2	idea	idea	NOUN
cord-018764-02l423mk	147	3	proved	prove	VERB
cord-018764-02l423mk	147	4	inadequate	inadequate	ADJ
cord-018764-02l423mk	147	5	,	,	PUNCT
cord-018764-02l423mk	147	6	however	however	ADV
cord-018764-02l423mk	147	7	,	,	PUNCT
cord-018764-02l423mk	147	8	when	when	SCONJ
cord-018764-02l423mk	147	9	this	this	DET
cord-018764-02l423mk	147	10	same	same	ADJ
cord-018764-02l423mk	147	11	group	group	NOUN
cord-018764-02l423mk	147	12	subsequently	subsequently	ADV
cord-018764-02l423mk	147	13	reported	report	VERB
cord-018764-02l423mk	147	14	dyserythropoiesis	dyserythropoiesis	NOUN
cord-018764-02l423mk	147	15	and	and	CCONJ
cord-018764-02l423mk	147	16	erythrophagocytosis	erythrophagocytosis	NOUN
cord-018764-02l423mk	147	17	in	in	ADP
cord-018764-02l423mk	147	18	vivax	vivax	PROPN
cord-018764-02l423mk	147	19	malaria	malaria	PROPN
cord-018764-02l423mk	147	20	,	,	PUNCT
cord-018764-02l423mk	147	21	in	in	ADP
cord-018764-02l423mk	147	22	which	which	PRON
cord-018764-02l423mk	147	23	parasitised	parasitise	VERB
cord-018764-02l423mk	147	24	red	red	ADJ
cord-018764-02l423mk	147	25	cells	cell	NOUN
cord-018764-02l423mk	147	26	do	do	AUX
cord-018764-02l423mk	147	27	not	not	PART
cord-018764-02l423mk	147	28	sequester	sequester	VERB
cord-018764-02l423mk	147	29	[	[	X
cord-018764-02l423mk	147	30	84	84	NUM
cord-018764-02l423mk	147	31	]	]	PUNCT
cord-018764-02l423mk	147	32	.	.	PUNCT
cord-018764-02l423mk	148	1	some	some	DET
cord-018764-02l423mk	148	2	time	time	NOUN
cord-018764-02l423mk	148	3	ago	ago	ADV
cord-018764-02l423mk	148	4	an	an	DET
cord-018764-02l423mk	148	5	undefined	undefined	ADJ
cord-018764-02l423mk	148	6	product	product	NOUN
cord-018764-02l423mk	148	7	in	in	ADP
cord-018764-02l423mk	148	8	macrophage	macrophage	NOUN
cord-018764-02l423mk	148	9	supernatants	supernatant	NOUN
cord-018764-02l423mk	148	10	[	[	PUNCT
cord-018764-02l423mk	148	11	85	85	NUM
cord-018764-02l423mk	148	12	]	]	PUNCT
cord-018764-02l423mk	148	13	,	,	PUNCT
cord-018764-02l423mk	148	14	later	later	ADV
cord-018764-02l423mk	148	15	identified	identify	VERB
cord-018764-02l423mk	148	16	as	as	ADP
cord-018764-02l423mk	148	17	tnf	tnf	PROPN
cord-018764-02l423mk	148	18	[	[	PUNCT
cord-018764-02l423mk	148	19	86	86	NUM
cord-018764-02l423mk	148	20	]	]	PUNCT
cord-018764-02l423mk	148	21	,	,	PUNCT
cord-018764-02l423mk	148	22	was	be	AUX
cord-018764-02l423mk	148	23	found	find	VERB
cord-018764-02l423mk	148	24	to	to	PART
cord-018764-02l423mk	148	25	inhibit	inhibit	VERB
cord-018764-02l423mk	148	26	the	the	DET
cord-018764-02l423mk	148	27	growth	growth	NOUN
cord-018764-02l423mk	148	28	and	and	CCONJ
cord-018764-02l423mk	148	29	differentiation	differentiation	NOUN
cord-018764-02l423mk	148	30	of	of	ADP
cord-018764-02l423mk	148	31	erythroid	erythroid	ADJ
cord-018764-02l423mk	148	32	progenitor	progenitor	NOUN
cord-018764-02l423mk	148	33	cells	cell	NOUN
cord-018764-02l423mk	148	34	.	.	PUNCT
cord-018764-02l423mk	149	1	when	when	SCONJ
cord-018764-02l423mk	149	2	rtnf	rtnf	PROPN
cord-018764-02l423mk	149	3	became	become	VERB
cord-018764-02l423mk	149	4	available	available	ADJ
cord-018764-02l423mk	149	5	,	,	PUNCT
cord-018764-02l423mk	149	6	the	the	DET
cord-018764-02l423mk	149	7	dyserythropoiesis	dyserythropoiesis	NOUN
cord-018764-02l423mk	149	8	and	and	CCONJ
cord-018764-02l423mk	149	9	erythrophagocytosis	erythrophagocytosis	NOUN
cord-018764-02l423mk	149	10	seen	see	VERB
cord-018764-02l423mk	149	11	in	in	ADP
cord-018764-02l423mk	149	12	terminal	terminal	ADJ
cord-018764-02l423mk	149	13	plasmodium	plasmodium	PROPN
cord-018764-02l423mk	149	14	vinckei	vinckei	PROPN
cord-018764-02l423mk	149	15	-	-	PUNCT
cord-018764-02l423mk	149	16	infected	infect	VERB
cord-018764-02l423mk	149	17	mice	mouse	NOUN
cord-018764-02l423mk	149	18	was	be	AUX
cord-018764-02l423mk	149	19	reproduced	reproduce	VERB
cord-018764-02l423mk	149	20	by	by	ADP
cord-018764-02l423mk	149	21	giving	give	VERB
cord-018764-02l423mk	149	22	a	a	DET
cord-018764-02l423mk	149	23	single	single	ADJ
cord-018764-02l423mk	149	24	injection	injection	NOUN
cord-018764-02l423mk	149	25	early	early	ADV
cord-018764-02l423mk	149	26	in	in	ADP
cord-018764-02l423mk	149	27	the	the	DET
cord-018764-02l423mk	149	28	course	course	NOUN
cord-018764-02l423mk	149	29	of	of	ADP
cord-018764-02l423mk	149	30	the	the	DET
cord-018764-02l423mk	149	31	infection	infection	NOUN
cord-018764-02l423mk	149	32	[	[	X
cord-018764-02l423mk	149	33	87	87	NUM
cord-018764-02l423mk	149	34	]	]	PUNCT
cord-018764-02l423mk	149	35	.	.	PUNCT
cord-018764-02l423mk	150	1	phagocytosis	phagocytosis	NOUN
cord-018764-02l423mk	150	2	of	of	ADP
cord-018764-02l423mk	150	3	erythroblasts	erythroblast	NOUN
cord-018764-02l423mk	150	4	in	in	ADP
cord-018764-02l423mk	150	5	bone	bone	NOUN
cord-018764-02l423mk	150	6	marrow	marrow	NOUN
cord-018764-02l423mk	150	7	,	,	PUNCT
cord-018764-02l423mk	150	8	a	a	DET
cord-018764-02l423mk	150	9	phenomenon	phenomenon	NOUN
cord-018764-02l423mk	150	10	also	also	ADV
cord-018764-02l423mk	150	11	reported	report	VERB
cord-018764-02l423mk	150	12	by	by	ADP
cord-018764-02l423mk	150	13	wickramasinghe	wickramasinghe	PROPN
cord-018764-02l423mk	150	14	et	et	PROPN
cord-018764-02l423mk	150	15	al	al	PROPN
cord-018764-02l423mk	151	1	[	[	PUNCT
cord-018764-02l423mk	151	2	83	83	NUM
cord-018764-02l423mk	151	3	,	,	PUNCT
cord-018764-02l423mk	151	4	84	84	NUM
cord-018764-02l423mk	151	5	]	]	PUNCT
cord-018764-02l423mk	151	6	in	in	ADP
cord-018764-02l423mk	151	7	human	human	ADJ
cord-018764-02l423mk	151	8	malaria	malaria	NOUN
cord-018764-02l423mk	151	9	,	,	PUNCT
cord-018764-02l423mk	151	10	also	also	ADV
cord-018764-02l423mk	151	11	occurred	occur	VERB
cord-018764-02l423mk	151	12	.	.	PUNCT
cord-018764-02l423mk	152	1	decreased	decrease	VERB
cord-018764-02l423mk	152	2	erythropoiesis	erythropoiesis	NOUN
cord-018764-02l423mk	152	3	was	be	AUX
cord-018764-02l423mk	152	4	subsequently	subsequently	ADV
cord-018764-02l423mk	152	5	reported	report	VERB
cord-018764-02l423mk	152	6	in	in	ADP
cord-018764-02l423mk	152	7	mice	mouse	NOUN
cord-018764-02l423mk	152	8	receiving	receive	VERB
cord-018764-02l423mk	152	9	continuous	continuous	ADJ
cord-018764-02l423mk	152	10	tnf	tnf	PROPN
cord-018764-02l423mk	152	11	infusions	infusion	NOUN
cord-018764-02l423mk	152	12	via	via	ADP
cord-018764-02l423mk	152	13	implanted	implant	VERB
cord-018764-02l423mk	152	14	osmotic	osmotic	ADJ
cord-018764-02l423mk	152	15	pumps	pump	NOUN
cord-018764-02l423mk	152	16	,	,	PUNCT
cord-018764-02l423mk	152	17	and	and	CCONJ
cord-018764-02l423mk	152	18	mice	mouse	NOUN
cord-018764-02l423mk	152	19	expressing	express	VERB
cord-018764-02l423mk	152	20	high	high	ADJ
cord-018764-02l423mk	152	21	levels	level	NOUN
cord-018764-02l423mk	152	22	of	of	ADP
cord-018764-02l423mk	152	23	human	human	PROPN
cord-018764-02l423mk	152	24	tnf	tnf	PROPN
cord-018764-02l423mk	152	25	have	have	AUX
cord-018764-02l423mk	152	26	been	be	AUX
cord-018764-02l423mk	152	27	shown	show	VERB
cord-018764-02l423mk	152	28	to	to	PART
cord-018764-02l423mk	152	29	become	become	VERB
cord-018764-02l423mk	152	30	markedly	markedly	ADV
cord-018764-02l423mk	152	31	anaemic	anaemic	ADJ
cord-018764-02l423mk	152	32	during	during	ADP
cord-018764-02l423mk	152	33	malaria	malaria	NOUN
cord-018764-02l423mk	152	34	infections	infection	NOUN
cord-018764-02l423mk	153	1	[	[	X
cord-018764-02l423mk	153	2	68	68	NUM
cord-018764-02l423mk	153	3	]	]	PUNCT
cord-018764-02l423mk	153	4	,	,	PUNCT
cord-018764-02l423mk	153	5	even	even	ADV
cord-018764-02l423mk	153	6	though	though	SCONJ
cord-018764-02l423mk	153	7	parasite	parasite	ADJ
cord-018764-02l423mk	153	8	numbers	number	NOUN
cord-018764-02l423mk	153	9	,	,	PUNCT
cord-018764-02l423mk	153	10	and	and	CCONJ
cord-018764-02l423mk	153	11	therefore	therefore	ADV
cord-018764-02l423mk	153	12	red	red	ADJ
cord-018764-02l423mk	153	13	cell	cell	NOUN
cord-018764-02l423mk	153	14	loss	loss	NOUN
cord-018764-02l423mk	153	15	post	post	ADJ
cord-018764-02l423mk	153	16	-	-	ADJ
cord-018764-02l423mk	153	17	schizogony	schizogony	ADJ
cord-018764-02l423mk	153	18	,	,	PUNCT
cord-018764-02l423mk	153	19	are	be	AUX
cord-018764-02l423mk	153	20	considerably	considerably	ADV
cord-018764-02l423mk	153	21	reduced	reduce	VERB
cord-018764-02l423mk	153	22	.	.	PUNCT
cord-018764-02l423mk	154	1	the	the	DET
cord-018764-02l423mk	154	2	past	past	ADJ
cord-018764-02l423mk	154	3	decade	decade	NOUN
cord-018764-02l423mk	154	4	has	have	AUX
cord-018764-02l423mk	154	5	seen	see	VERB
cord-018764-02l423mk	154	6	an	an	DET
cord-018764-02l423mk	154	7	expansion	expansion	NOUN
cord-018764-02l423mk	154	8	of	of	ADP
cord-018764-02l423mk	154	9	this	this	DET
cord-018764-02l423mk	154	10	line	line	NOUN
cord-018764-02l423mk	154	11	of	of	ADP
cord-018764-02l423mk	154	12	enquiry	enquiry	NOUN
cord-018764-02l423mk	154	13	into	into	ADP
cord-018764-02l423mk	154	14	human	human	ADJ
cord-018764-02l423mk	154	15	malaria	malaria	NOUN
cord-018764-02l423mk	154	16	,	,	PUNCT
cord-018764-02l423mk	154	17	and	and	CCONJ
cord-018764-02l423mk	154	18	also	also	ADV
cord-018764-02l423mk	154	19	the	the	DET
cord-018764-02l423mk	154	20	number	number	NOUN
cord-018764-02l423mk	154	21	of	of	ADP
cord-018764-02l423mk	154	22	cytokines	cytokine	NOUN
cord-018764-02l423mk	154	23	,	,	PUNCT
cord-018764-02l423mk	154	24	both	both	CCONJ
cord-018764-02l423mk	154	25	pro	pro	ADJ
cord-018764-02l423mk	154	26	-	-	ADJ
cord-018764-02l423mk	154	27	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	154	28	and	and	CCONJ
cord-018764-02l423mk	154	29	anti	anti	ADJ
cord-018764-02l423mk	154	30	-	-	ADJ
cord-018764-02l423mk	154	31	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	154	32	[	[	X
cord-018764-02l423mk	154	33	88	88	NUM
cord-018764-02l423mk	154	34	,	,	PUNCT
cord-018764-02l423mk	154	35	89	89	NUM
cord-018764-02l423mk	154	36	]	]	PUNCT
cord-018764-02l423mk	154	37	in	in	ADP
cord-018764-02l423mk	154	38	absolute	absolute	ADJ
cord-018764-02l423mk	154	39	amounts	amount	NOUN
cord-018764-02l423mk	154	40	and	and	CCONJ
cord-018764-02l423mk	154	41	ratios	ratio	NOUN
cord-018764-02l423mk	154	42	[	[	X
cord-018764-02l423mk	154	43	90	90	NUM
cord-018764-02l423mk	154	44	,	,	PUNCT
cord-018764-02l423mk	154	45	91	91	NUM
cord-018764-02l423mk	154	46	]	]	PUNCT
cord-018764-02l423mk	154	47	,	,	PUNCT
cord-018764-02l423mk	154	48	that	that	PRON
cord-018764-02l423mk	154	49	have	have	AUX
cord-018764-02l423mk	154	50	been	be	AUX
cord-018764-02l423mk	154	51	investigated	investigate	VERB
cord-018764-02l423mk	154	52	in	in	ADP
cord-018764-02l423mk	154	53	this	this	DET
cord-018764-02l423mk	154	54	context	context	NOUN
cord-018764-02l423mk	154	55	.	.	PUNCT
cord-018764-02l423mk	155	1	investigations	investigation	NOUN
cord-018764-02l423mk	155	2	have	have	AUX
cord-018764-02l423mk	155	3	been	be	AUX
cord-018764-02l423mk	155	4	extended	extend	VERB
cord-018764-02l423mk	155	5	to	to	PART
cord-018764-02l423mk	155	6	include	include	VERB
cord-018764-02l423mk	155	7	other	other	ADJ
cord-018764-02l423mk	155	8	pro	pro	ADJ
cord-018764-02l423mk	155	9	-	-	ADJ
cord-018764-02l423mk	155	10	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	155	11	cytokines	cytokine	NOUN
cord-018764-02l423mk	155	12	,	,	PUNCT
cord-018764-02l423mk	155	13	such	such	ADJ
cord-018764-02l423mk	155	14	as	as	ADP
cord-018764-02l423mk	155	15	il-12	il-12	NOUN
cord-018764-02l423mk	155	16	[	[	X
cord-018764-02l423mk	155	17	92	92	NUM
cord-018764-02l423mk	155	18	]	]	PUNCT
cord-018764-02l423mk	155	19	and	and	CCONJ
cord-018764-02l423mk	155	20	fasl	fasl	NOUN
cord-018764-02l423mk	155	21	[	[	PUNCT
cord-018764-02l423mk	155	22	93	93	NUM
cord-018764-02l423mk	155	23	]	]	PUNCT
cord-018764-02l423mk	155	24	,	,	PUNCT
cord-018764-02l423mk	155	25	and	and	CCONJ
cord-018764-02l423mk	155	26	examined	examine	VERB
cord-018764-02l423mk	155	27	the	the	DET
cord-018764-02l423mk	155	28	role	role	NOUN
cord-018764-02l423mk	155	29	in	in	ADP
cord-018764-02l423mk	155	30	anaemia	anaemia	NOUN
cord-018764-02l423mk	155	31	of	of	ADP
cord-018764-02l423mk	155	32	the	the	DET
cord-018764-02l423mk	155	33	persistence	persistence	NOUN
cord-018764-02l423mk	155	34	of	of	ADP
cord-018764-02l423mk	155	35	cytokine	cytokine	NOUN
cord-018764-02l423mk	155	36	production	production	NOUN
cord-018764-02l423mk	155	37	during	during	ADP
cord-018764-02l423mk	155	38	malaria	malaria	NOUN
cord-018764-02l423mk	155	39	infection	infection	NOUN
cord-018764-02l423mk	155	40	[	[	X
cord-018764-02l423mk	155	41	94	94	NUM
cord-018764-02l423mk	155	42	]	]	PUNCT
cord-018764-02l423mk	155	43	.	.	PUNCT
cord-018764-02l423mk	156	1	another	another	DET
cord-018764-02l423mk	156	2	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	156	3	cytokine	cytokine	NOUN
cord-018764-02l423mk	156	4	,	,	PUNCT
cord-018764-02l423mk	156	5	macrophage	macrophage	NOUN
cord-018764-02l423mk	156	6	inhibitory	inhibitory	ADJ
cord-018764-02l423mk	156	7	factor	factor	NOUN
cord-018764-02l423mk	156	8	(	(	PUNCT
cord-018764-02l423mk	156	9	mif	mif	PROPN
cord-018764-02l423mk	156	10	)	)	PUNCT
cord-018764-02l423mk	156	11	that	that	PRON
cord-018764-02l423mk	156	12	is	be	AUX
cord-018764-02l423mk	156	13	increased	increase	VERB
cord-018764-02l423mk	156	14	in	in	ADP
cord-018764-02l423mk	156	15	malaria	malaria	NOUN
cord-018764-02l423mk	156	16	,	,	PUNCT
cord-018764-02l423mk	156	17	and	and	CCONJ
cord-018764-02l423mk	156	18	induced	induce	VERB
cord-018764-02l423mk	156	19	by	by	ADP
cord-018764-02l423mk	156	20	tnf	tnf	PROPN
cord-018764-02l423mk	156	21	,	,	PUNCT
cord-018764-02l423mk	156	22	has	have	AUX
cord-018764-02l423mk	156	23	been	be	AUX
cord-018764-02l423mk	156	24	shown	show	VERB
cord-018764-02l423mk	156	25	to	to	PART
cord-018764-02l423mk	156	26	cause	cause	VERB
cord-018764-02l423mk	156	27	dyserythropoiesis	dyserythropoiesis	NOUN
cord-018764-02l423mk	156	28	in	in	ADP
cord-018764-02l423mk	156	29	in	in	X
cord-018764-02l423mk	156	30	vitro	vitro	X
cord-018764-02l423mk	156	31	studies	study	NOUN
cord-018764-02l423mk	156	32	on	on	ADP
cord-018764-02l423mk	156	33	bone	bone	NOUN
cord-018764-02l423mk	156	34	marrow	marrow	NOUN
cord-018764-02l423mk	156	35	cells	cell	NOUN
cord-018764-02l423mk	156	36	[	[	X
cord-018764-02l423mk	156	37	95	95	NUM
cord-018764-02l423mk	156	38	,	,	PUNCT
cord-018764-02l423mk	156	39	96	96	NUM
cord-018764-02l423mk	156	40	]	]	PUNCT
cord-018764-02l423mk	156	41	.	.	PUNCT
cord-018764-02l423mk	157	1	thus	thus	ADV
cord-018764-02l423mk	157	2	,	,	PUNCT
cord-018764-02l423mk	157	3	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	157	4	cytokines	cytokine	NOUN
cord-018764-02l423mk	157	5	generated	generate	VERB
cord-018764-02l423mk	157	6	during	during	ADP
cord-018764-02l423mk	157	7	malaria	malaria	NOUN
cord-018764-02l423mk	157	8	are	be	AUX
cord-018764-02l423mk	157	9	a	a	DET
cord-018764-02l423mk	157	10	major	major	ADJ
cord-018764-02l423mk	157	11	determinant	determinant	NOUN
cord-018764-02l423mk	157	12	of	of	ADP
cord-018764-02l423mk	157	13	the	the	DET
cord-018764-02l423mk	157	14	degree	degree	NOUN
cord-018764-02l423mk	157	15	to	to	PART
cord-018764-02l423mk	157	16	which	which	PRON
cord-018764-02l423mk	157	17	anaemia	anaemia	NOUN
cord-018764-02l423mk	157	18	influences	influence	VERB
cord-018764-02l423mk	157	19	the	the	DET
cord-018764-02l423mk	157	20	amount	amount	NOUN
cord-018764-02l423mk	157	21	of	of	ADP
cord-018764-02l423mk	157	22	oxygen	oxygen	NOUN
cord-018764-02l423mk	157	23	that	that	PRON
cord-018764-02l423mk	157	24	reaches	reach	VERB
cord-018764-02l423mk	157	25	tissues	tissue	NOUN
cord-018764-02l423mk	157	26	in	in	ADP
cord-018764-02l423mk	157	27	malaria	malaria	NOUN
cord-018764-02l423mk	157	28	.	.	PUNCT
cord-018764-02l423mk	158	1	mitochondria	mitochondria	PROPN
cord-018764-02l423mk	158	2	are	be	AUX
cord-018764-02l423mk	158	3	vital	vital	ADJ
cord-018764-02l423mk	158	4	to	to	ADP
cord-018764-02l423mk	158	5	energy	energy	NOUN
cord-018764-02l423mk	158	6	(	(	PUNCT
cord-018764-02l423mk	158	7	atp	atp	NOUN
cord-018764-02l423mk	158	8	)	)	PUNCT
cord-018764-02l423mk	158	9	generation	generation	NOUN
cord-018764-02l423mk	158	10	through	through	ADP
cord-018764-02l423mk	158	11	cellular	cellular	ADJ
cord-018764-02l423mk	158	12	respiration	respiration	NOUN
cord-018764-02l423mk	158	13	.	.	PUNCT
cord-018764-02l423mk	159	1	cellular	cellular	ADJ
cord-018764-02l423mk	159	2	respiration	respiration	NOUN
cord-018764-02l423mk	159	3	requires	require	VERB
cord-018764-02l423mk	159	4	oxygen	oxygen	NOUN
cord-018764-02l423mk	159	5	and	and	CCONJ
cord-018764-02l423mk	159	6	pyruvate	pyruvate	NOUN
cord-018764-02l423mk	159	7	,	,	PUNCT
cord-018764-02l423mk	159	8	as	as	ADV
cord-018764-02l423mk	159	9	well	well	ADV
cord-018764-02l423mk	159	10	as	as	ADP
cord-018764-02l423mk	159	11	multiple	multiple	ADJ
cord-018764-02l423mk	159	12	cofactors	cofactor	NOUN
cord-018764-02l423mk	159	13	and	and	CCONJ
cord-018764-02l423mk	159	14	active	active	ADJ
cord-018764-02l423mk	159	15	transport	transport	NOUN
cord-018764-02l423mk	159	16	molecules	molecule	NOUN
cord-018764-02l423mk	159	17	.	.	PUNCT
cord-018764-02l423mk	160	1	within	within	ADP
cord-018764-02l423mk	160	2	the	the	DET
cord-018764-02l423mk	160	3	matrix	matrix	NOUN
cord-018764-02l423mk	160	4	of	of	ADP
cord-018764-02l423mk	160	5	the	the	DET
cord-018764-02l423mk	160	6	mitochondrion	mitochondrion	NOUN
cord-018764-02l423mk	160	7	organelle	organelle	NOUN
cord-018764-02l423mk	160	8	,	,	PUNCT
cord-018764-02l423mk	160	9	pyruvate	pyruvate	NOUN
cord-018764-02l423mk	160	10	is	be	AUX
cord-018764-02l423mk	160	11	catabolised	catabolise	VERB
cord-018764-02l423mk	160	12	via	via	ADP
cord-018764-02l423mk	160	13	the	the	DET
cord-018764-02l423mk	160	14	krebs	krebs	PROPN
cord-018764-02l423mk	160	15	cycle	cycle	NOUN
cord-018764-02l423mk	160	16	and	and	CCONJ
cord-018764-02l423mk	160	17	oxidative	oxidative	ADJ
cord-018764-02l423mk	160	18	phosphorylation	phosphorylation	NOUN
cord-018764-02l423mk	160	19	(	(	PUNCT
cord-018764-02l423mk	160	20	involving	involve	VERB
cord-018764-02l423mk	160	21	nadh	nadh	PROPN
cord-018764-02l423mk	160	22	and	and	CCONJ
cord-018764-02l423mk	160	23	fadh2	fadh2	PROPN
cord-018764-02l423mk	160	24	)	)	PUNCT
cord-018764-02l423mk	160	25	to	to	PART
cord-018764-02l423mk	160	26	generate	generate	VERB
cord-018764-02l423mk	160	27	atp	atp	NOUN
cord-018764-02l423mk	160	28	.	.	PUNCT
cord-018764-02l423mk	161	1	when	when	SCONJ
cord-018764-02l423mk	161	2	this	this	DET
cord-018764-02l423mk	161	3	series	series	NOUN
cord-018764-02l423mk	161	4	of	of	ADP
cord-018764-02l423mk	161	5	reactions	reaction	NOUN
cord-018764-02l423mk	161	6	are	be	AUX
cord-018764-02l423mk	161	7	100	100	NUM
cord-018764-02l423mk	161	8	%	%	NOUN
cord-018764-02l423mk	161	9	efficient	efficient	ADJ
cord-018764-02l423mk	161	10	(	(	PUNCT
cord-018764-02l423mk	161	11	unlikely	unlikely	ADJ
cord-018764-02l423mk	161	12	in	in	ADP
cord-018764-02l423mk	161	13	vivo	vivo	NOUN
cord-018764-02l423mk	161	14	)	)	PUNCT
cord-018764-02l423mk	161	15	,	,	PUNCT
cord-018764-02l423mk	161	16	1	1	NUM
cord-018764-02l423mk	161	17	molecule	molecule	NOUN
cord-018764-02l423mk	161	18	of	of	ADP
cord-018764-02l423mk	161	19	glucose	glucose	NOUN
cord-018764-02l423mk	161	20	generates	generate	VERB
cord-018764-02l423mk	161	21	2	2	NUM
cord-018764-02l423mk	161	22	molecules	molecule	NOUN
cord-018764-02l423mk	161	23	of	of	ADP
cord-018764-02l423mk	161	24	pyruvate	pyruvate	NOUN
cord-018764-02l423mk	161	25	,	,	PUNCT
cord-018764-02l423mk	161	26	which	which	PRON
cord-018764-02l423mk	161	27	are	be	AUX
cord-018764-02l423mk	161	28	further	far	ADV
cord-018764-02l423mk	161	29	catabolised	catabolise	VERB
cord-018764-02l423mk	161	30	to	to	ADP
cord-018764-02l423mk	161	31	water	water	NOUN
cord-018764-02l423mk	161	32	and	and	CCONJ
cord-018764-02l423mk	161	33	carbon	carbon	NOUN
cord-018764-02l423mk	161	34	dioxide	dioxide	NOUN
cord-018764-02l423mk	161	35	with	with	ADP
cord-018764-02l423mk	161	36	the	the	DET
cord-018764-02l423mk	161	37	concomitant	concomitant	ADJ
cord-018764-02l423mk	161	38	generation	generation	NOUN
cord-018764-02l423mk	161	39	of	of	ADP
cord-018764-02l423mk	161	40	36	36	NUM
cord-018764-02l423mk	161	41	molecules	molecule	NOUN
cord-018764-02l423mk	161	42	of	of	ADP
cord-018764-02l423mk	161	43	atp	atp	NOUN
cord-018764-02l423mk	161	44	.	.	PUNCT
cord-018764-02l423mk	162	1	in	in	ADP
cord-018764-02l423mk	162	2	comparison	comparison	NOUN
cord-018764-02l423mk	162	3	,	,	PUNCT
cord-018764-02l423mk	162	4	during	during	ADP
cord-018764-02l423mk	162	5	anaerobic	anaerobic	PROPN
cord-018764-02l423mk	162	6	glucose	glucose	NOUN
cord-018764-02l423mk	162	7	catabolism	catabolism	NOUN
cord-018764-02l423mk	162	8	,	,	PUNCT
cord-018764-02l423mk	162	9	pyruvate	pyruvate	NOUN
cord-018764-02l423mk	162	10	is	be	AUX
cord-018764-02l423mk	162	11	converted	convert	VERB
cord-018764-02l423mk	162	12	to	to	AUX
cord-018764-02l423mk	162	13	lactate	lactate	VERB
cord-018764-02l423mk	162	14	with	with	ADP
cord-018764-02l423mk	162	15	the	the	DET
cord-018764-02l423mk	162	16	concomitant	concomitant	ADJ
cord-018764-02l423mk	162	17	generation	generation	NOUN
cord-018764-02l423mk	162	18	of	of	ADP
cord-018764-02l423mk	162	19	2	2	NUM
cord-018764-02l423mk	162	20	molecules	molecule	NOUN
cord-018764-02l423mk	162	21	of	of	ADP
cord-018764-02l423mk	162	22	atp	atp	PROPN
cord-018764-02l423mk	162	23	,	,	PUNCT
cord-018764-02l423mk	162	24	a	a	DET
cord-018764-02l423mk	162	25	process	process	NOUN
cord-018764-02l423mk	162	26	that	that	PRON
cord-018764-02l423mk	162	27	also	also	ADV
cord-018764-02l423mk	162	28	facilitates	facilitate	VERB
cord-018764-02l423mk	162	29	regeneration	regeneration	NOUN
cord-018764-02l423mk	162	30	of	of	ADP
cord-018764-02l423mk	162	31	nadh	nadh	PROPN
cord-018764-02l423mk	162	32	and	and	CCONJ
cord-018764-02l423mk	162	33	fadh2	fadh2	PROPN
cord-018764-02l423mk	162	34	.	.	PUNCT
cord-018764-02l423mk	163	1	evidence	evidence	NOUN
cord-018764-02l423mk	163	2	is	be	AUX
cord-018764-02l423mk	163	3	accumulating	accumulate	VERB
cord-018764-02l423mk	163	4	that	that	DET
cord-018764-02l423mk	163	5	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	163	6	cytokines	cytokine	NOUN
cord-018764-02l423mk	163	7	,	,	PUNCT
cord-018764-02l423mk	163	8	as	as	SCONJ
cord-018764-02l423mk	163	9	released	release	VERB
cord-018764-02l423mk	163	10	in	in	ADP
cord-018764-02l423mk	163	11	malaria	malaria	NOUN
cord-018764-02l423mk	163	12	,	,	PUNCT
cord-018764-02l423mk	163	13	sepsis	sepsis	NOUN
cord-018764-02l423mk	163	14	,	,	PUNCT
cord-018764-02l423mk	163	15	and	and	CCONJ
cord-018764-02l423mk	163	16	viral	viral	ADJ
cord-018764-02l423mk	163	17	diseases	disease	NOUN
cord-018764-02l423mk	163	18	,	,	PUNCT
cord-018764-02l423mk	163	19	induce	induce	VERB
cord-018764-02l423mk	163	20	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	163	21	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	163	22	and	and	CCONJ
cord-018764-02l423mk	163	23	dysregulate	dysregulate	ADJ
cord-018764-02l423mk	163	24	cellular	cellular	ADJ
cord-018764-02l423mk	163	25	respiration	respiration	NOUN
cord-018764-02l423mk	163	26	,	,	PUNCT
cord-018764-02l423mk	163	27	resulting	result	VERB
cord-018764-02l423mk	163	28	in	in	ADP
cord-018764-02l423mk	163	29	the	the	DET
cord-018764-02l423mk	163	30	incomplete	incomplete	ADJ
cord-018764-02l423mk	163	31	catabolism	catabolism	NOUN
cord-018764-02l423mk	163	32	of	of	ADP
cord-018764-02l423mk	163	33	pyruvate	pyruvate	NOUN
cord-018764-02l423mk	163	34	.	.	PUNCT
cord-018764-02l423mk	164	1	the	the	DET
cord-018764-02l423mk	164	2	process	process	NOUN
cord-018764-02l423mk	164	3	,	,	PUNCT
cord-018764-02l423mk	164	4	termed	term	VERB
cord-018764-02l423mk	164	5	'	'	PUNCT
cord-018764-02l423mk	164	6	cytopathic	cytopathic	ADJ
cord-018764-02l423mk	164	7	hypoxia	hypoxia	NOUN
cord-018764-02l423mk	164	8	'	'	PUNCT
cord-018764-02l423mk	164	9	[	[	X
cord-018764-02l423mk	164	10	97	97	NUM
cord-018764-02l423mk	164	11	]	]	PUNCT
cord-018764-02l423mk	164	12	,	,	PUNCT
cord-018764-02l423mk	164	13	mimics	mimic	VERB
cord-018764-02l423mk	164	14	cellular	cellular	ADJ
cord-018764-02l423mk	164	15	hypoxia	hypoxia	NOUN
cord-018764-02l423mk	164	16	,	,	PUNCT
cord-018764-02l423mk	164	17	in	in	SCONJ
cord-018764-02l423mk	164	18	that	that	SCONJ
cord-018764-02l423mk	164	19	it	it	PRON
cord-018764-02l423mk	164	20	results	result	VERB
cord-018764-02l423mk	164	21	in	in	ADP
cord-018764-02l423mk	164	22	the	the	DET
cord-018764-02l423mk	164	23	incomplete	incomplete	ADJ
cord-018764-02l423mk	164	24	catabolism	catabolism	NOUN
cord-018764-02l423mk	164	25	of	of	ADP
cord-018764-02l423mk	164	26	pyruvate	pyruvate	NOUN
cord-018764-02l423mk	164	27	and	and	CCONJ
cord-018764-02l423mk	164	28	accumulation	accumulation	NOUN
cord-018764-02l423mk	164	29	of	of	ADP
cord-018764-02l423mk	164	30	lactate	lactate	NOUN
cord-018764-02l423mk	164	31	.	.	PUNCT
cord-018764-02l423mk	165	1	awareness	awareness	NOUN
cord-018764-02l423mk	165	2	of	of	ADP
cord-018764-02l423mk	165	3	this	this	DET
cord-018764-02l423mk	165	4	mechanism	mechanism	NOUN
cord-018764-02l423mk	165	5	began	begin	VERB
cord-018764-02l423mk	165	6	with	with	ADP
cord-018764-02l423mk	165	7	oxygen	oxygen	NOUN
cord-018764-02l423mk	165	8	tension	tension	NOUN
cord-018764-02l423mk	165	9	being	be	AUX
cord-018764-02l423mk	165	10	shown	show	VERB
cord-018764-02l423mk	165	11	to	to	PART
cord-018764-02l423mk	165	12	be	be	AUX
cord-018764-02l423mk	165	13	increased	increase	VERB
cord-018764-02l423mk	165	14	in	in	ADP
cord-018764-02l423mk	165	15	septic	septic	ADJ
cord-018764-02l423mk	165	16	rats	rat	NOUN
cord-018764-02l423mk	165	17	[	[	X
cord-018764-02l423mk	165	18	98	98	NUM
cord-018764-02l423mk	165	19	]	]	PUNCT
cord-018764-02l423mk	165	20	and	and	CCONJ
cord-018764-02l423mk	165	21	patients	patient	NOUN
cord-018764-02l423mk	165	22	[	[	X
cord-018764-02l423mk	165	23	99	99	NUM
cord-018764-02l423mk	165	24	]	]	PUNCT
cord-018764-02l423mk	165	25	.	.	PUNCT
cord-018764-02l423mk	166	1	a	a	DET
cord-018764-02l423mk	166	2	cytokine	cytokine	NOUN
cord-018764-02l423mk	166	3	model	model	NOUN
cord-018764-02l423mk	166	4	of	of	ADP
cord-018764-02l423mk	166	5	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	166	6	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	166	7	has	have	AUX
cord-018764-02l423mk	166	8	since	since	ADV
cord-018764-02l423mk	166	9	been	be	AUX
cord-018764-02l423mk	166	10	developed	develop	VERB
cord-018764-02l423mk	166	11	in	in	SCONJ
cord-018764-02l423mk	166	12	which	which	DET
cord-018764-02l423mk	166	13	impairment	impairment	NOUN
cord-018764-02l423mk	166	14	of	of	ADP
cord-018764-02l423mk	166	15	cellular	cellular	ADJ
cord-018764-02l423mk	166	16	respiration	respiration	NOUN
cord-018764-02l423mk	166	17	occurs	occur	VERB
cord-018764-02l423mk	166	18	following	follow	VERB
cord-018764-02l423mk	166	19	induction	induction	NOUN
cord-018764-02l423mk	166	20	of	of	ADP
cord-018764-02l423mk	166	21	sepsis	sepsis	NOUN
cord-018764-02l423mk	166	22	(	(	PUNCT
cord-018764-02l423mk	166	23	or	or	CCONJ
cord-018764-02l423mk	166	24	exposure	exposure	NOUN
cord-018764-02l423mk	166	25	to	to	ADP
cord-018764-02l423mk	166	26	pro	pro	ADJ
cord-018764-02l423mk	166	27	-	-	ADJ
cord-018764-02l423mk	166	28	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	166	29	cytokines	cytokine	NOUN
cord-018764-02l423mk	166	30	)	)	PUNCT
cord-018764-02l423mk	166	31	,	,	PUNCT
cord-018764-02l423mk	166	32	despite	despite	SCONJ
cord-018764-02l423mk	166	33	sufficient	sufficient	ADJ
cord-018764-02l423mk	166	34	oxygen	oxygen	NOUN
cord-018764-02l423mk	166	35	supply	supply	NOUN
cord-018764-02l423mk	166	36	[	[	X
cord-018764-02l423mk	166	37	97	97	NUM
cord-018764-02l423mk	166	38	,	,	PUNCT
cord-018764-02l423mk	166	39	100	100	NUM
cord-018764-02l423mk	166	40	,	,	PUNCT
cord-018764-02l423mk	166	41	101	101	NUM
cord-018764-02l423mk	166	42	]	]	PUNCT
cord-018764-02l423mk	166	43	.	.	PUNCT
cord-018764-02l423mk	167	1	more	more	ADV
cord-018764-02l423mk	167	2	recently	recently	ADV
cord-018764-02l423mk	167	3	,	,	PUNCT
cord-018764-02l423mk	167	4	impairment	impairment	NOUN
cord-018764-02l423mk	167	5	of	of	ADP
cord-018764-02l423mk	167	6	enzyme	enzyme	NOUN
cord-018764-02l423mk	167	7	activity	activity	NOUN
cord-018764-02l423mk	167	8	associated	associate	VERB
cord-018764-02l423mk	167	9	with	with	ADP
cord-018764-02l423mk	167	10	the	the	DET
cord-018764-02l423mk	167	11	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	167	12	complexes	complex	NOUN
cord-018764-02l423mk	167	13	has	have	AUX
cord-018764-02l423mk	167	14	been	be	AUX
cord-018764-02l423mk	167	15	demonstrated	demonstrate	VERB
cord-018764-02l423mk	167	16	in	in	ADP
cord-018764-02l423mk	167	17	muscle	muscle	NOUN
cord-018764-02l423mk	167	18	biopsies	biopsy	NOUN
cord-018764-02l423mk	167	19	retrieved	retrieve	VERB
cord-018764-02l423mk	167	20	from	from	ADP
cord-018764-02l423mk	167	21	rodent	rodent	NOUN
cord-018764-02l423mk	167	22	models	model	NOUN
cord-018764-02l423mk	167	23	of	of	ADP
cord-018764-02l423mk	167	24	sepsis	sepsis	NOUN
cord-018764-02l423mk	167	25	[	[	X
cord-018764-02l423mk	167	26	102	102	NUM
cord-018764-02l423mk	167	27	]	]	PUNCT
cord-018764-02l423mk	167	28	and	and	CCONJ
cord-018764-02l423mk	167	29	septic	septic	ADJ
cord-018764-02l423mk	167	30	patients	patient	NOUN
cord-018764-02l423mk	167	31	[	[	PUNCT
cord-018764-02l423mk	167	32	103	103	NUM
cord-018764-02l423mk	167	33	,	,	PUNCT
cord-018764-02l423mk	167	34	104	104	NUM
cord-018764-02l423mk	167	35	]	]	PUNCT
cord-018764-02l423mk	167	36	.	.	PUNCT
cord-018764-02l423mk	168	1	the	the	DET
cord-018764-02l423mk	168	2	observation	observation	NOUN
cord-018764-02l423mk	168	3	that	that	SCONJ
cord-018764-02l423mk	168	4	the	the	DET
cord-018764-02l423mk	168	5	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	168	6	cytokines	cytokine	NOUN
cord-018764-02l423mk	168	7	implicated	implicate	VERB
cord-018764-02l423mk	168	8	in	in	ADP
cord-018764-02l423mk	168	9	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	168	10	shutdown	shutdown	NOUN
cord-018764-02l423mk	168	11	are	be	AUX
cord-018764-02l423mk	168	12	prominent	prominent	ADJ
cord-018764-02l423mk	168	13	in	in	ADP
cord-018764-02l423mk	168	14	both	both	DET
cord-018764-02l423mk	168	15	sepsis	sepsis	NOUN
cord-018764-02l423mk	168	16	and	and	CCONJ
cord-018764-02l423mk	168	17	malaria	malaria	NOUN
cord-018764-02l423mk	168	18	[	[	PUNCT
cord-018764-02l423mk	168	19	105	105	NUM
cord-018764-02l423mk	168	20	,	,	PUNCT
cord-018764-02l423mk	168	21	106	106	NUM
cord-018764-02l423mk	168	22	]	]	PUNCT
cord-018764-02l423mk	168	23	supports	support	VERB
cord-018764-02l423mk	168	24	such	such	ADJ
cord-018764-02l423mk	168	25	organelle	organelle	NOUN
cord-018764-02l423mk	168	26	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	168	27	being	be	AUX
cord-018764-02l423mk	168	28	equally	equally	ADV
cord-018764-02l423mk	168	29	plausible	plausible	ADJ
cord-018764-02l423mk	168	30	in	in	ADP
cord-018764-02l423mk	168	31	malaria	malaria	NOUN
cord-018764-02l423mk	168	32	.	.	PUNCT
cord-018764-02l423mk	169	1	researchers	researcher	NOUN
cord-018764-02l423mk	169	2	are	be	AUX
cord-018764-02l423mk	169	3	also	also	ADV
cord-018764-02l423mk	169	4	becoming	become	VERB
cord-018764-02l423mk	169	5	aware	aware	ADJ
cord-018764-02l423mk	169	6	that	that	SCONJ
cord-018764-02l423mk	169	7	,	,	PUNCT
cord-018764-02l423mk	169	8	beyond	beyond	ADP
cord-018764-02l423mk	169	9	energy	energy	NOUN
cord-018764-02l423mk	169	10	production	production	NOUN
cord-018764-02l423mk	169	11	,	,	PUNCT
cord-018764-02l423mk	169	12	mitochondria	mitochondria	PROPN
cord-018764-02l423mk	169	13	also	also	ADV
cord-018764-02l423mk	169	14	play	play	VERB
cord-018764-02l423mk	169	15	a	a	DET
cord-018764-02l423mk	169	16	vital	vital	ADJ
cord-018764-02l423mk	169	17	role	role	NOUN
cord-018764-02l423mk	169	18	in	in	ADP
cord-018764-02l423mk	169	19	cell	cell	NOUN
cord-018764-02l423mk	169	20	homeostasis	homeostasis	NOUN
cord-018764-02l423mk	169	21	through	through	ADP
cord-018764-02l423mk	169	22	generation	generation	NOUN
cord-018764-02l423mk	169	23	and	and	CCONJ
cord-018764-02l423mk	169	24	detoxification	detoxification	NOUN
cord-018764-02l423mk	169	25	of	of	ADP
cord-018764-02l423mk	169	26	reactive	reactive	ADJ
cord-018764-02l423mk	169	27	oxygen	oxygen	NOUN
cord-018764-02l423mk	169	28	species	specie	NOUN
cord-018764-02l423mk	169	29	[	[	PUNCT
cord-018764-02l423mk	169	30	107	107	NUM
cord-018764-02l423mk	169	31	]	]	PUNCT
cord-018764-02l423mk	169	32	.	.	PUNCT
cord-018764-02l423mk	170	1	the	the	DET
cord-018764-02l423mk	170	2	accelerated	accelerated	ADJ
cord-018764-02l423mk	170	3	oxidative	oxidative	ADJ
cord-018764-02l423mk	170	4	damage	damage	NOUN
cord-018764-02l423mk	170	5	that	that	PRON
cord-018764-02l423mk	170	6	accompanies	accompany	VERB
cord-018764-02l423mk	170	7	sepsis	sepsis	NOUN
cord-018764-02l423mk	170	8	could	could	AUX
cord-018764-02l423mk	170	9	be	be	AUX
cord-018764-02l423mk	170	10	both	both	CCONJ
cord-018764-02l423mk	170	11	a	a	DET
cord-018764-02l423mk	170	12	cause	cause	NOUN
cord-018764-02l423mk	170	13	and	and	CCONJ
cord-018764-02l423mk	170	14	a	a	DET
cord-018764-02l423mk	170	15	consequence	consequence	NOUN
cord-018764-02l423mk	170	16	of	of	ADP
cord-018764-02l423mk	170	17	cytokine	cytokine	NOUN
cord-018764-02l423mk	170	18	-	-	PUNCT
cord-018764-02l423mk	170	19	induced	induce	VERB
cord-018764-02l423mk	170	20	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	170	21	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	170	22	.	.	PUNCT
cord-018764-02l423mk	171	1	interestingly	interestingly	ADV
cord-018764-02l423mk	171	2	,	,	PUNCT
cord-018764-02l423mk	171	3	the	the	DET
cord-018764-02l423mk	171	4	ultrastructural	ultrastructural	ADJ
cord-018764-02l423mk	171	5	damage	damage	NOUN
cord-018764-02l423mk	171	6	reported	report	VERB
cord-018764-02l423mk	171	7	to	to	PART
cord-018764-02l423mk	171	8	accompany	accompany	VERB
cord-018764-02l423mk	171	9	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	171	10	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	171	11	in	in	ADP
cord-018764-02l423mk	171	12	sepsis	sepsis	NOUN
cord-018764-02l423mk	171	13	[	[	X
cord-018764-02l423mk	171	14	102	102	NUM
cord-018764-02l423mk	171	15	]	]	PUNCT
cord-018764-02l423mk	171	16	reflects	reflect	VERB
cord-018764-02l423mk	171	17	maegraith	maegraith	PROPN
cord-018764-02l423mk	171	18	's	's	PART
cord-018764-02l423mk	171	19	observations	observation	NOUN
cord-018764-02l423mk	171	20	in	in	ADP
cord-018764-02l423mk	171	21	monkey	monkey	NOUN
cord-018764-02l423mk	171	22	malaria	malaria	NOUN
cord-018764-02l423mk	172	1	[	[	PUNCT
cord-018764-02l423mk	172	2	108	108	NUM
cord-018764-02l423mk	172	3	]	]	PUNCT
cord-018764-02l423mk	172	4	[	[	X
cord-018764-02l423mk	172	5	109	109	NUM
cord-018764-02l423mk	172	6	]	]	PUNCT
cord-018764-02l423mk	172	7	[	[	X
cord-018764-02l423mk	172	8	110	110	NUM
cord-018764-02l423mk	172	9	]	]	PUNCT
cord-018764-02l423mk	172	10	decades	decade	NOUN
cord-018764-02l423mk	172	11	ago	ago	ADV
cord-018764-02l423mk	172	12	.	.	PUNCT
cord-018764-02l423mk	173	1	metabolic	metabolic	ADJ
cord-018764-02l423mk	173	2	acidosis	acidosis	NOUN
cord-018764-02l423mk	173	3	,	,	PUNCT
cord-018764-02l423mk	173	4	often	often	ADV
cord-018764-02l423mk	173	5	associated	associate	VERB
cord-018764-02l423mk	173	6	with	with	ADP
cord-018764-02l423mk	173	7	hyperlactataemia	hyperlactataemia	PROPN
cord-018764-02l423mk	173	8	,	,	PUNCT
cord-018764-02l423mk	173	9	has	have	AUX
cord-018764-02l423mk	173	10	been	be	AUX
cord-018764-02l423mk	173	11	described	describe	VERB
cord-018764-02l423mk	173	12	in	in	ADP
cord-018764-02l423mk	173	13	african	african	ADJ
cord-018764-02l423mk	173	14	children	child	NOUN
cord-018764-02l423mk	173	15	with	with	ADP
cord-018764-02l423mk	173	16	severe	severe	ADJ
cord-018764-02l423mk	173	17	falciparum	falciparum	NOUN
cord-018764-02l423mk	173	18	malaria	malaria	NOUN
cord-018764-02l423mk	173	19	[	[	PUNCT
cord-018764-02l423mk	173	20	111	111	NUM
cord-018764-02l423mk	173	21	,	,	PUNCT
cord-018764-02l423mk	173	22	112	112	NUM
cord-018764-02l423mk	173	23	]	]	PUNCT
cord-018764-02l423mk	173	24	.	.	PUNCT
cord-018764-02l423mk	174	1	it	it	PRON
cord-018764-02l423mk	174	2	is	be	AUX
cord-018764-02l423mk	174	3	not	not	PART
cord-018764-02l423mk	174	4	unique	unique	ADJ
cord-018764-02l423mk	174	5	to	to	ADP
cord-018764-02l423mk	174	6	this	this	DET
cord-018764-02l423mk	174	7	disease	disease	NOUN
cord-018764-02l423mk	174	8	,	,	PUNCT
cord-018764-02l423mk	174	9	being	be	AUX
cord-018764-02l423mk	174	10	seen	see	VERB
cord-018764-02l423mk	174	11	in	in	ADP
cord-018764-02l423mk	174	12	viral	viral	ADJ
cord-018764-02l423mk	174	13	,	,	PUNCT
cord-018764-02l423mk	174	14	rickettsial	rickettsial	NOUN
cord-018764-02l423mk	174	15	and	and	CCONJ
cord-018764-02l423mk	174	16	bacterial	bacterial	ADJ
cord-018764-02l423mk	174	17	infections	infection	NOUN
cord-018764-02l423mk	174	18	[	[	PUNCT
cord-018764-02l423mk	174	19	113	113	NUM
cord-018764-02l423mk	174	20	]	]	PUNCT
cord-018764-02l423mk	174	21	as	as	ADV
cord-018764-02l423mk	174	22	well	well	ADV
cord-018764-02l423mk	174	23	as	as	ADP
cord-018764-02l423mk	174	24	acute	acute	ADJ
cord-018764-02l423mk	174	25	gastroenteritis	gastroenteritis	NOUN
cord-018764-02l423mk	174	26	,	,	PUNCT
cord-018764-02l423mk	174	27	where	where	SCONJ
cord-018764-02l423mk	174	28	its	its	PRON
cord-018764-02l423mk	174	29	prevalence	prevalence	NOUN
cord-018764-02l423mk	174	30	is	be	AUX
cord-018764-02l423mk	174	31	higher	high	ADJ
cord-018764-02l423mk	174	32	than	than	ADP
cord-018764-02l423mk	174	33	in	in	ADP
cord-018764-02l423mk	174	34	malaria	malaria	NOUN
cord-018764-02l423mk	174	35	[	[	X
cord-018764-02l423mk	174	36	114	114	NUM
cord-018764-02l423mk	174	37	]	]	PUNCT
cord-018764-02l423mk	174	38	.	.	PUNCT
cord-018764-02l423mk	175	1	the	the	DET
cord-018764-02l423mk	175	2	terms	term	NOUN
cord-018764-02l423mk	175	3	hyperlactataemia	hyperlactataemia	NOUN
cord-018764-02l423mk	175	4	and	and	CCONJ
cord-018764-02l423mk	175	5	lactic	lactic	ADJ
cord-018764-02l423mk	175	6	acidosis	acidosis	NOUN
cord-018764-02l423mk	175	7	are	be	AUX
cord-018764-02l423mk	175	8	often	often	ADV
cord-018764-02l423mk	175	9	mistakenly	mistakenly	ADV
cord-018764-02l423mk	175	10	used	use	VERB
cord-018764-02l423mk	175	11	interchangeably	interchangeably	NOUN
cord-018764-02l423mk	175	12	in	in	ADP
cord-018764-02l423mk	175	13	the	the	DET
cord-018764-02l423mk	175	14	malaria	malaria	NOUN
cord-018764-02l423mk	175	15	literature	literature	NOUN
cord-018764-02l423mk	175	16	.	.	PUNCT
cord-018764-02l423mk	176	1	as	as	ADV
cord-018764-02l423mk	176	2	often	often	ADV
cord-018764-02l423mk	176	3	reviewed	review	VERB
cord-018764-02l423mk	176	4	in	in	ADP
cord-018764-02l423mk	176	5	the	the	DET
cord-018764-02l423mk	176	6	basic	basic	ADJ
cord-018764-02l423mk	176	7	literature	literature	NOUN
cord-018764-02l423mk	177	1	[	[	PUNCT
cord-018764-02l423mk	177	2	115	115	NUM
cord-018764-02l423mk	177	3	]	]	PUNCT
cord-018764-02l423mk	177	4	[	[	X
cord-018764-02l423mk	177	5	116	116	NUM
cord-018764-02l423mk	177	6	]	]	X
cord-018764-02l423mk	177	7	[	[	X
cord-018764-02l423mk	177	8	117	117	NUM
cord-018764-02l423mk	177	9	]	]	X
cord-018764-02l423mk	177	10	[	[	X
cord-018764-02l423mk	177	11	118	118	NUM
cord-018764-02l423mk	177	12	]	]	PUNCT
cord-018764-02l423mk	177	13	,	,	PUNCT
cord-018764-02l423mk	177	14	protons	proton	NOUN
cord-018764-02l423mk	177	15	(	(	PUNCT
cord-018764-02l423mk	177	16	h	h	NOUN
cord-018764-02l423mk	177	17	+	+	NUM
cord-018764-02l423mk	177	18	,	,	PUNCT
cord-018764-02l423mk	177	19	the	the	DET
cord-018764-02l423mk	177	20	basis	basis	NOUN
cord-018764-02l423mk	177	21	of	of	ADP
cord-018764-02l423mk	177	22	acidosis	acidosis	NOUN
cord-018764-02l423mk	177	23	)	)	PUNCT
cord-018764-02l423mk	177	24	are	be	AUX
cord-018764-02l423mk	177	25	not	not	PART
cord-018764-02l423mk	177	26	formed	form	VERB
cord-018764-02l423mk	177	27	when	when	SCONJ
cord-018764-02l423mk	177	28	atp	atp	NOUN
cord-018764-02l423mk	177	29	and	and	CCONJ
cord-018764-02l423mk	177	30	lactate	lactate	NOUN
cord-018764-02l423mk	177	31	are	be	AUX
cord-018764-02l423mk	177	32	generated	generate	VERB
cord-018764-02l423mk	177	33	during	during	ADP
cord-018764-02l423mk	177	34	glycolysis	glycolysis	NOUN
cord-018764-02l423mk	177	35	,	,	PUNCT
cord-018764-02l423mk	177	36	but	but	CCONJ
cord-018764-02l423mk	177	37	on	on	ADP
cord-018764-02l423mk	177	38	the	the	DET
cord-018764-02l423mk	177	39	subsequent	subsequent	ADJ
cord-018764-02l423mk	177	40	hydrolysis	hydrolysis	NOUN
cord-018764-02l423mk	177	41	of	of	ADP
cord-018764-02l423mk	177	42	atp	atp	NOUN
cord-018764-02l423mk	177	43	in	in	ADP
cord-018764-02l423mk	177	44	tissues	tissue	NOUN
cord-018764-02l423mk	177	45	.	.	PUNCT
cord-018764-02l423mk	178	1	every	every	DET
cord-018764-02l423mk	178	2	time	time	NOUN
cord-018764-02l423mk	178	3	a	a	DET
cord-018764-02l423mk	178	4	molecule	molecule	NOUN
cord-018764-02l423mk	178	5	of	of	ADP
cord-018764-02l423mk	178	6	atp	atp	NOUN
cord-018764-02l423mk	178	7	undergoes	undergo	VERB
cord-018764-02l423mk	178	8	hydrolysis	hydrolysis	NOUN
cord-018764-02l423mk	178	9	,	,	PUNCT
cord-018764-02l423mk	178	10	a	a	DET
cord-018764-02l423mk	178	11	proton	proton	NOUN
cord-018764-02l423mk	178	12	is	be	AUX
cord-018764-02l423mk	178	13	released	release	VERB
cord-018764-02l423mk	178	14	.	.	PUNCT
cord-018764-02l423mk	179	1	if	if	SCONJ
cord-018764-02l423mk	179	2	this	this	PRON
cord-018764-02l423mk	179	3	occurs	occur	VERB
cord-018764-02l423mk	179	4	under	under	ADP
cord-018764-02l423mk	179	5	aero	aero	NOUN
cord-018764-02l423mk	179	6	-	-	PUNCT
cord-018764-02l423mk	179	7	bic	bic	NOUN
cord-018764-02l423mk	179	8	conditions	condition	NOUN
cord-018764-02l423mk	179	9	,	,	PUNCT
cord-018764-02l423mk	179	10	these	these	DET
cord-018764-02l423mk	179	11	protons	proton	NOUN
cord-018764-02l423mk	179	12	are	be	AUX
cord-018764-02l423mk	179	13	consumed	consume	VERB
cord-018764-02l423mk	179	14	within	within	ADP
cord-018764-02l423mk	179	15	atp	atp	NOUN
cord-018764-02l423mk	179	16	regeneration	regeneration	NOUN
cord-018764-02l423mk	179	17	from	from	ADP
cord-018764-02l423mk	179	18	adp	adp	PROPN
cord-018764-02l423mk	179	19	,	,	PUNCT
cord-018764-02l423mk	179	20	and	and	CCONJ
cord-018764-02l423mk	179	21	ph	ph	NOUN
cord-018764-02l423mk	179	22	remains	remain	VERB
cord-018764-02l423mk	179	23	normal	normal	ADJ
cord-018764-02l423mk	179	24	,	,	PUNCT
cord-018764-02l423mk	179	25	i.e.	i.e.	X
cord-018764-02l423mk	179	26	acidosis	acidosis	NOUN
cord-018764-02l423mk	179	27	does	do	AUX
cord-018764-02l423mk	179	28	not	not	PART
cord-018764-02l423mk	179	29	occur	occur	VERB
cord-018764-02l423mk	179	30	.	.	PUNCT
cord-018764-02l423mk	180	1	in	in	ADP
cord-018764-02l423mk	180	2	contrast	contrast	NOUN
cord-018764-02l423mk	180	3	,	,	PUNCT
cord-018764-02l423mk	180	4	if	if	SCONJ
cord-018764-02l423mk	180	5	the	the	DET
cord-018764-02l423mk	180	6	mitochondria	mitochondria	NOUN
cord-018764-02l423mk	180	7	are	be	AUX
cord-018764-02l423mk	180	8	not	not	PART
cord-018764-02l423mk	180	9	functioning	function	VERB
cord-018764-02l423mk	180	10	adequately	adequately	ADV
cord-018764-02l423mk	180	11	,	,	PUNCT
cord-018764-02l423mk	180	12	whether	whether	SCONJ
cord-018764-02l423mk	180	13	through	through	ADP
cord-018764-02l423mk	180	14	insufficient	insufficient	ADJ
cord-018764-02l423mk	180	15	oxygen	oxygen	NOUN
cord-018764-02l423mk	180	16	supply	supply	NOUN
cord-018764-02l423mk	180	17	or	or	CCONJ
cord-018764-02l423mk	180	18	an	an	DET
cord-018764-02l423mk	180	19	inability	inability	NOUN
cord-018764-02l423mk	180	20	to	to	PART
cord-018764-02l423mk	180	21	use	use	VERB
cord-018764-02l423mk	180	22	it	it	PRON
cord-018764-02l423mk	180	23	,	,	PUNCT
cord-018764-02l423mk	180	24	atp	atp	NOUN
cord-018764-02l423mk	180	25	regenerates	regenerate	VERB
cord-018764-02l423mk	180	26	under	under	ADP
cord-018764-02l423mk	180	27	anaerobic	anaerobic	NOUN
cord-018764-02l423mk	180	28	condition	condition	NOUN
cord-018764-02l423mk	180	29	,	,	PUNCT
cord-018764-02l423mk	180	30	and	and	CCONJ
cord-018764-02l423mk	180	31	the	the	DET
cord-018764-02l423mk	180	32	protons	proton	NOUN
cord-018764-02l423mk	180	33	are	be	AUX
cord-018764-02l423mk	180	34	not	not	PART
cord-018764-02l423mk	180	35	consumed	consume	VERB
cord-018764-02l423mk	180	36	.	.	PUNCT
cord-018764-02l423mk	181	1	hence	hence	ADV
cord-018764-02l423mk	181	2	,	,	PUNCT
cord-018764-02l423mk	181	3	once	once	SCONJ
cord-018764-02l423mk	181	4	the	the	DET
cord-018764-02l423mk	181	5	buffering	buffering	NOUN
cord-018764-02l423mk	181	6	capacity	capacity	NOUN
cord-018764-02l423mk	181	7	of	of	ADP
cord-018764-02l423mk	181	8	the	the	DET
cord-018764-02l423mk	181	9	body	body	NOUN
cord-018764-02l423mk	181	10	is	be	AUX
cord-018764-02l423mk	181	11	exceeded	exceed	VERB
cord-018764-02l423mk	181	12	,	,	PUNCT
cord-018764-02l423mk	181	13	acidosis	acidosis	NOUN
cord-018764-02l423mk	181	14	occurs	occur	VERB
cord-018764-02l423mk	181	15	.	.	PUNCT
cord-018764-02l423mk	182	1	in	in	ADP
cord-018764-02l423mk	182	2	short	short	ADJ
cord-018764-02l423mk	182	3	,	,	PUNCT
cord-018764-02l423mk	182	4	metabolic	metabolic	ADJ
cord-018764-02l423mk	182	5	acidosis	acidosis	NOUN
cord-018764-02l423mk	182	6	requires	require	VERB
cord-018764-02l423mk	182	7	the	the	DET
cord-018764-02l423mk	182	8	ratio	ratio	NOUN
cord-018764-02l423mk	182	9	of	of	ADP
cord-018764-02l423mk	182	10	glycolytic	glycolytic	NOUN
cord-018764-02l423mk	182	11	(	(	PUNCT
cord-018764-02l423mk	182	12	i.e.	i.e.	X
cord-018764-02l423mk	182	13	anaerobic	anaerobic	PROPN
cord-018764-02l423mk	182	14	)	)	PUNCT
cord-018764-02l423mk	182	15	atp	atp	NOUN
cord-018764-02l423mk	182	16	hydrolysis	hydrolysis	NOUN
cord-018764-02l423mk	182	17	to	to	ADP
cord-018764-02l423mk	182	18	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	182	19	(	(	PUNCT
cord-018764-02l423mk	182	20	i.e.	i.e.	X
cord-018764-02l423mk	182	21	aerobic	aerobic	ADJ
cord-018764-02l423mk	182	22	)	)	PUNCT
cord-018764-02l423mk	182	23	atp	atp	NOUN
cord-018764-02l423mk	182	24	hydrolysis	hydrolysis	NOUN
cord-018764-02l423mk	182	25	to	to	PART
cord-018764-02l423mk	182	26	reach	reach	VERB
cord-018764-02l423mk	182	27	a	a	DET
cord-018764-02l423mk	182	28	point	point	NOUN
cord-018764-02l423mk	182	29	at	at	ADP
cord-018764-02l423mk	182	30	which	which	PRON
cord-018764-02l423mk	182	31	the	the	DET
cord-018764-02l423mk	182	32	buffering	buffering	NOUN
cord-018764-02l423mk	182	33	systems	system	NOUN
cord-018764-02l423mk	182	34	can	can	AUX
cord-018764-02l423mk	182	35	no	no	ADV
cord-018764-02l423mk	182	36	longer	long	ADV
cord-018764-02l423mk	182	37	cope	cope	VERB
cord-018764-02l423mk	182	38	.	.	PUNCT
cord-018764-02l423mk	183	1	pathological	pathological	ADJ
cord-018764-02l423mk	183	2	changes	change	NOUN
cord-018764-02l423mk	183	3	in	in	ADP
cord-018764-02l423mk	183	4	the	the	DET
cord-018764-02l423mk	183	5	buffering	buffering	NOUN
cord-018764-02l423mk	183	6	system	system	NOUN
cord-018764-02l423mk	183	7	can	can	AUX
cord-018764-02l423mk	183	8	be	be	AUX
cord-018764-02l423mk	183	9	a	a	DET
cord-018764-02l423mk	183	10	major	major	ADJ
cord-018764-02l423mk	183	11	determinant	determinant	NOUN
cord-018764-02l423mk	183	12	of	of	ADP
cord-018764-02l423mk	183	13	when	when	SCONJ
cord-018764-02l423mk	183	14	this	this	PRON
cord-018764-02l423mk	183	15	occurs	occur	VERB
cord-018764-02l423mk	183	16	.	.	PUNCT
cord-018764-02l423mk	184	1	high	high	ADJ
cord-018764-02l423mk	184	2	lactate	lactate	NOUN
cord-018764-02l423mk	184	3	levels	level	NOUN
cord-018764-02l423mk	184	4	have	have	AUX
cord-018764-02l423mk	184	5	traditionally	traditionally	ADV
cord-018764-02l423mk	184	6	been	be	AUX
cord-018764-02l423mk	184	7	seen	see	VERB
cord-018764-02l423mk	184	8	not	not	PART
cord-018764-02l423mk	184	9	only	only	ADV
cord-018764-02l423mk	184	10	as	as	ADP
cord-018764-02l423mk	184	11	a	a	DET
cord-018764-02l423mk	184	12	marker	marker	NOUN
cord-018764-02l423mk	184	13	for	for	ADP
cord-018764-02l423mk	184	14	poor	poor	ADJ
cord-018764-02l423mk	184	15	oxygen	oxygen	NOUN
cord-018764-02l423mk	184	16	delivery	delivery	NOUN
cord-018764-02l423mk	184	17	in	in	ADP
cord-018764-02l423mk	184	18	disease	disease	NOUN
cord-018764-02l423mk	184	19	states	state	NOUN
cord-018764-02l423mk	184	20	,	,	PUNCT
cord-018764-02l423mk	184	21	but	but	CCONJ
cord-018764-02l423mk	184	22	also	also	ADV
cord-018764-02l423mk	184	23	a	a	DET
cord-018764-02l423mk	184	24	consequence	consequence	NOUN
cord-018764-02l423mk	184	25	of	of	ADP
cord-018764-02l423mk	184	26	it	it	PRON
cord-018764-02l423mk	184	27	,	,	PUNCT
cord-018764-02l423mk	184	28	and	and	CCONJ
cord-018764-02l423mk	184	29	the	the	DET
cord-018764-02l423mk	184	30	cause	cause	NOUN
cord-018764-02l423mk	184	31	of	of	ADP
cord-018764-02l423mk	184	32	the	the	DET
cord-018764-02l423mk	184	33	acidosis	acidosis	NOUN
cord-018764-02l423mk	184	34	.	.	PUNCT
cord-018764-02l423mk	185	1	for	for	ADP
cord-018764-02l423mk	185	2	some	some	DET
cord-018764-02l423mk	185	3	time	time	NOUN
cord-018764-02l423mk	185	4	hyperlactataemia	hyperlactataemia	PROPN
cord-018764-02l423mk	185	5	has	have	AUX
cord-018764-02l423mk	185	6	been	be	AUX
cord-018764-02l423mk	185	7	regarded	regard	VERB
cord-018764-02l423mk	185	8	as	as	ADP
cord-018764-02l423mk	185	9	a	a	DET
cord-018764-02l423mk	185	10	functionally	functionally	ADV
cord-018764-02l423mk	185	11	relevant	relevant	ADJ
cord-018764-02l423mk	185	12	marker	marker	NOUN
cord-018764-02l423mk	185	13	for	for	ADP
cord-018764-02l423mk	185	14	a	a	DET
cord-018764-02l423mk	185	15	poor	poor	ADJ
cord-018764-02l423mk	185	16	prognosis	prognosis	NOUN
cord-018764-02l423mk	185	17	in	in	ADP
cord-018764-02l423mk	185	18	both	both	DET
cord-018764-02l423mk	185	19	sepsis	sepsis	NOUN
cord-018764-02l423mk	185	20	[	[	X
cord-018764-02l423mk	185	21	119	119	NUM
cord-018764-02l423mk	185	22	]	]	PUNCT
cord-018764-02l423mk	185	23	and	and	CCONJ
cord-018764-02l423mk	185	24	malaria	malaria	NOUN
cord-018764-02l423mk	185	25	[	[	PUNCT
cord-018764-02l423mk	185	26	66	66	NUM
cord-018764-02l423mk	185	27	,	,	PUNCT
cord-018764-02l423mk	185	28	112	112	NUM
cord-018764-02l423mk	185	29	,	,	PUNCT
cord-018764-02l423mk	185	30	120	120	NUM
cord-018764-02l423mk	185	31	]	]	PUNCT
cord-018764-02l423mk	185	32	.	.	PUNCT
cord-018764-02l423mk	186	1	although	although	SCONJ
cord-018764-02l423mk	186	2	the	the	DET
cord-018764-02l423mk	186	3	sepsis	sepsis	NOUN
cord-018764-02l423mk	186	4	world	world	NOUN
cord-018764-02l423mk	186	5	now	now	ADV
cord-018764-02l423mk	186	6	discusses	discuss	VERB
cord-018764-02l423mk	186	7	several	several	ADJ
cord-018764-02l423mk	186	8	origins	origin	NOUN
cord-018764-02l423mk	186	9	for	for	ADP
cord-018764-02l423mk	186	10	the	the	DET
cord-018764-02l423mk	186	11	lactate	lactate	NOUN
cord-018764-02l423mk	186	12	increase	increase	NOUN
cord-018764-02l423mk	186	13	,	,	PUNCT
cord-018764-02l423mk	186	14	including	include	VERB
cord-018764-02l423mk	186	15	inflammation	inflammation	NOUN
cord-018764-02l423mk	186	16	-	-	PUNCT
cord-018764-02l423mk	186	17	induced	induce	VERB
cord-018764-02l423mk	186	18	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	186	19	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	186	20	[	[	X
cord-018764-02l423mk	186	21	97	97	NUM
cord-018764-02l423mk	186	22	]	]	PUNCT
cord-018764-02l423mk	186	23	,	,	PUNCT
cord-018764-02l423mk	186	24	in	in	ADP
cord-018764-02l423mk	186	25	falciparum	falciparum	NOUN
cord-018764-02l423mk	186	26	malaria	malaria	NOUN
cord-018764-02l423mk	186	27	it	it	PRON
cord-018764-02l423mk	186	28	is	be	AUX
cord-018764-02l423mk	186	29	still	still	ADV
cord-018764-02l423mk	186	30	generally	generally	ADV
cord-018764-02l423mk	186	31	attributed	attribute	VERB
cord-018764-02l423mk	186	32	to	to	ADP
cord-018764-02l423mk	186	33	a	a	DET
cord-018764-02l423mk	186	34	reduced	reduced	ADJ
cord-018764-02l423mk	186	35	oxygen	oxygen	NOUN
cord-018764-02l423mk	186	36	supply	supply	NOUN
cord-018764-02l423mk	186	37	,	,	PUNCT
cord-018764-02l423mk	186	38	mostly	mostly	ADV
cord-018764-02l423mk	186	39	through	through	ADP
cord-018764-02l423mk	186	40	microvascular	microvascular	ADJ
cord-018764-02l423mk	186	41	occlusion	occlusion	NOUN
cord-018764-02l423mk	186	42	by	by	ADP
cord-018764-02l423mk	186	43	sequestered	sequester	VERB
cord-018764-02l423mk	186	44	parasitised	parasitise	VERB
cord-018764-02l423mk	186	45	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	186	46	[	[	X
cord-018764-02l423mk	186	47	121	121	NUM
cord-018764-02l423mk	186	48	]	]	PUNCT
cord-018764-02l423mk	186	49	.	.	PUNCT
cord-018764-02l423mk	187	1	other	other	ADJ
cord-018764-02l423mk	187	2	mechanisms	mechanism	NOUN
cord-018764-02l423mk	187	3	are	be	AUX
cord-018764-02l423mk	187	4	known	know	VERB
cord-018764-02l423mk	187	5	to	to	PART
cord-018764-02l423mk	187	6	contribute	contribute	VERB
cord-018764-02l423mk	187	7	to	to	ADP
cord-018764-02l423mk	187	8	acidosis	acidosis	NOUN
cord-018764-02l423mk	187	9	in	in	ADP
cord-018764-02l423mk	187	10	malaria	malaria	NOUN
cord-018764-02l423mk	187	11	,	,	PUNCT
cord-018764-02l423mk	187	12	independent	independent	ADJ
cord-018764-02l423mk	187	13	of	of	ADP
cord-018764-02l423mk	187	14	lactate	lactate	ADJ
cord-018764-02l423mk	187	15	production	production	NOUN
cord-018764-02l423mk	187	16	,	,	PUNCT
cord-018764-02l423mk	187	17	e.g.	e.g.	ADV
cord-018764-02l423mk	187	18	acute	acute	ADJ
cord-018764-02l423mk	187	19	renal	renal	ADJ
cord-018764-02l423mk	187	20	failure	failure	NOUN
cord-018764-02l423mk	187	21	[	[	PUNCT
cord-018764-02l423mk	187	22	8	8	NUM
cord-018764-02l423mk	187	23	]	]	PUNCT
cord-018764-02l423mk	187	24	.	.	PUNCT
cord-018764-02l423mk	188	1	impaired	impair	VERB
cord-018764-02l423mk	188	2	hepatic	hepatic	ADJ
cord-018764-02l423mk	188	3	clearance	clearance	NOUN
cord-018764-02l423mk	188	4	[	[	PUNCT
cord-018764-02l423mk	188	5	8	8	NUM
cord-018764-02l423mk	188	6	,	,	PUNCT
cord-018764-02l423mk	188	7	112	112	NUM
cord-018764-02l423mk	188	8	]	]	PUNCT
cord-018764-02l423mk	188	9	,	,	PUNCT
cord-018764-02l423mk	188	10	production	production	NOUN
cord-018764-02l423mk	188	11	by	by	ADP
cord-018764-02l423mk	188	12	parasites	parasite	NOUN
cord-018764-02l423mk	188	13	,	,	PUNCT
cord-018764-02l423mk	188	14	and	and	CCONJ
cord-018764-02l423mk	188	15	,	,	PUNCT
cord-018764-02l423mk	188	16	in	in	ADP
cord-018764-02l423mk	188	17	some	some	DET
cord-018764-02l423mk	188	18	areas	area	NOUN
cord-018764-02l423mk	188	19	,	,	PUNCT
cord-018764-02l423mk	188	20	thiamine	thiamine	ADJ
cord-018764-02l423mk	188	21	deficiency	deficiency	NOUN
cord-018764-02l423mk	188	22	[	[	PUNCT
cord-018764-02l423mk	188	23	122	122	NUM
cord-018764-02l423mk	188	24	]	]	PUNCT
cord-018764-02l423mk	188	25	are	be	AUX
cord-018764-02l423mk	188	26	also	also	ADV
cord-018764-02l423mk	188	27	argued	argue	VERB
cord-018764-02l423mk	188	28	to	to	PART
cord-018764-02l423mk	188	29	contribute	contribute	VERB
cord-018764-02l423mk	188	30	to	to	ADP
cord-018764-02l423mk	188	31	lactate	lactate	NOUN
cord-018764-02l423mk	188	32	accumulation	accumulation	NOUN
cord-018764-02l423mk	188	33	independent	independent	ADJ
cord-018764-02l423mk	188	34	of	of	ADP
cord-018764-02l423mk	188	35	impaired	impaired	ADJ
cord-018764-02l423mk	188	36	cellular	cellular	ADJ
cord-018764-02l423mk	188	37	respiration	respiration	NOUN
cord-018764-02l423mk	188	38	.	.	PUNCT
cord-018764-02l423mk	189	1	thus	thus	ADV
cord-018764-02l423mk	189	2	,	,	PUNCT
cord-018764-02l423mk	189	3	as	as	SCONJ
cord-018764-02l423mk	189	4	described	describe	VERB
cord-018764-02l423mk	189	5	below	below	ADP
cord-018764-02l423mk	189	6	,	,	PUNCT
cord-018764-02l423mk	189	7	although	although	SCONJ
cord-018764-02l423mk	189	8	acidosis	acidosis	NOUN
cord-018764-02l423mk	189	9	and	and	CCONJ
cord-018764-02l423mk	189	10	hyperlactataemia	hyperlactataemia	PROPN
cord-018764-02l423mk	189	11	can	can	AUX
cord-018764-02l423mk	189	12	be	be	AUX
cord-018764-02l423mk	189	13	associated	associate	VERB
cord-018764-02l423mk	189	14	,	,	PUNCT
cord-018764-02l423mk	189	15	they	they	PRON
cord-018764-02l423mk	189	16	are	be	AUX
cord-018764-02l423mk	189	17	independent	independent	ADJ
cord-018764-02l423mk	189	18	cellular	cellular	ADJ
cord-018764-02l423mk	189	19	mechanisms	mechanism	NOUN
cord-018764-02l423mk	189	20	.	.	PUNCT
cord-018764-02l423mk	190	1	lactate	lactate	NOUN
cord-018764-02l423mk	190	2	anion	anion	NOUN
cord-018764-02l423mk	190	3	has	have	VERB
cord-018764-02l423mk	190	4	complex	complex	ADJ
cord-018764-02l423mk	190	5	roles	role	NOUN
cord-018764-02l423mk	190	6	in	in	ADP
cord-018764-02l423mk	190	7	biology	biology	NOUN
cord-018764-02l423mk	190	8	.	.	PUNCT
cord-018764-02l423mk	191	1	hyperlactataemia	hyperlactataemia	PROPN
cord-018764-02l423mk	191	2	may	may	AUX
cord-018764-02l423mk	191	3	be	be	AUX
cord-018764-02l423mk	191	4	associated	associate	VERB
cord-018764-02l423mk	191	5	with	with	ADP
cord-018764-02l423mk	191	6	acidosis	acidosis	NOUN
cord-018764-02l423mk	191	7	,	,	PUNCT
cord-018764-02l423mk	191	8	a	a	DET
cord-018764-02l423mk	191	9	normal	normal	ADJ
cord-018764-02l423mk	191	10	ph	ph	NOUN
cord-018764-02l423mk	191	11	,	,	PUNCT
cord-018764-02l423mk	191	12	or	or	CCONJ
cord-018764-02l423mk	191	13	alkalosis	alkalosis	NOUN
cord-018764-02l423mk	191	14	[	[	PUNCT
cord-018764-02l423mk	191	15	123	123	NUM
cord-018764-02l423mk	191	16	]	]	PUNCT
cord-018764-02l423mk	191	17	.	.	PUNCT
cord-018764-02l423mk	192	1	a	a	DET
cord-018764-02l423mk	192	2	recent	recent	ADJ
cord-018764-02l423mk	192	3	editorial	editorial	NOUN
cord-018764-02l423mk	192	4	in	in	ADP
cord-018764-02l423mk	192	5	critical	critical	ADJ
cord-018764-02l423mk	192	6	care	care	NOUN
cord-018764-02l423mk	192	7	medicine	medicine	NOUN
cord-018764-02l423mk	192	8	[	[	PUNCT
cord-018764-02l423mk	192	9	124	124	NUM
cord-018764-02l423mk	192	10	]	]	PUNCT
cord-018764-02l423mk	192	11	has	have	AUX
cord-018764-02l423mk	192	12	lucidly	lucidly	ADV
cord-018764-02l423mk	192	13	summarised	summarise	VERB
cord-018764-02l423mk	192	14	the	the	DET
cord-018764-02l423mk	192	15	key	key	ADJ
cord-018764-02l423mk	192	16	points	point	NOUN
cord-018764-02l423mk	192	17	of	of	ADP
cord-018764-02l423mk	192	18	the	the	DET
cord-018764-02l423mk	192	19	mechanism	mechanism	NOUN
cord-018764-02l423mk	192	20	of	of	ADP
cord-018764-02l423mk	192	21	metabolic	metabolic	ADJ
cord-018764-02l423mk	192	22	acidosis	acidosis	NOUN
cord-018764-02l423mk	192	23	in	in	ADP
cord-018764-02l423mk	192	24	sepsis	sepsis	NOUN
cord-018764-02l423mk	192	25	,	,	PUNCT
cord-018764-02l423mk	192	26	a	a	DET
cord-018764-02l423mk	192	27	condition	condition	NOUN
cord-018764-02l423mk	192	28	that	that	PRON
cord-018764-02l423mk	192	29	shares	share	VERB
cord-018764-02l423mk	192	30	systemic	systemic	ADJ
cord-018764-02l423mk	192	31	inflammation	inflammation	NOUN
cord-018764-02l423mk	192	32	and	and	CCONJ
cord-018764-02l423mk	192	33	a	a	DET
cord-018764-02l423mk	192	34	range	range	NOUN
cord-018764-02l423mk	192	35	of	of	ADP
cord-018764-02l423mk	192	36	its	its	PRON
cord-018764-02l423mk	192	37	consequences	consequence	NOUN
cord-018764-02l423mk	192	38	with	with	ADP
cord-018764-02l423mk	192	39	severe	severe	ADJ
cord-018764-02l423mk	192	40	malaria	malaria	NOUN
cord-018764-02l423mk	192	41	(	(	PUNCT
cord-018764-02l423mk	192	42	tab	tab	NOUN
cord-018764-02l423mk	192	43	.	.	PROPN
cord-018764-02l423mk	192	44	2	2	NUM
cord-018764-02l423mk	192	45	)	)	PUNCT
cord-018764-02l423mk	192	46	.	.	PUNCT
cord-018764-02l423mk	193	1	these	these	DET
cord-018764-02l423mk	193	2	authors	author	NOUN
cord-018764-02l423mk	193	3	argue	argue	VERB
cord-018764-02l423mk	193	4	against	against	ADP
cord-018764-02l423mk	193	5	lactate	lactate	NOUN
cord-018764-02l423mk	193	6	as	as	ADP
cord-018764-02l423mk	193	7	the	the	DET
cord-018764-02l423mk	193	8	cause	cause	NOUN
cord-018764-02l423mk	193	9	of	of	ADP
cord-018764-02l423mk	193	10	the	the	DET
cord-018764-02l423mk	193	11	acidosis	acidosis	NOUN
cord-018764-02l423mk	193	12	associated	associate	VERB
cord-018764-02l423mk	193	13	with	with	ADP
cord-018764-02l423mk	193	14	hypoxia	hypoxia	NOUN
cord-018764-02l423mk	193	15	.	.	PUNCT
cord-018764-02l423mk	194	1	instead	instead	ADV
cord-018764-02l423mk	194	2	,	,	PUNCT
cord-018764-02l423mk	194	3	they	they	PRON
cord-018764-02l423mk	194	4	note	note	VERB
cord-018764-02l423mk	194	5	the	the	DET
cord-018764-02l423mk	194	6	evidence	evidence	NOUN
cord-018764-02l423mk	194	7	that	that	SCONJ
cord-018764-02l423mk	194	8	during	during	ADP
cord-018764-02l423mk	194	9	hypoxia	hypoxia	NOUN
cord-018764-02l423mk	194	10	,	,	PUNCT
cord-018764-02l423mk	194	11	be	be	AUX
cord-018764-02l423mk	194	12	it	it	PRON
cord-018764-02l423mk	194	13	from	from	ADP
cord-018764-02l423mk	194	14	limited	limited	ADJ
cord-018764-02l423mk	194	15	oxygen	oxygen	NOUN
cord-018764-02l423mk	194	16	supply	supply	NOUN
cord-018764-02l423mk	194	17	or	or	CCONJ
cord-018764-02l423mk	194	18	utilisation	utilisation	NOUN
cord-018764-02l423mk	194	19	,	,	PUNCT
cord-018764-02l423mk	194	20	the	the	DET
cord-018764-02l423mk	194	21	unconsumed	unconsumed	ADJ
cord-018764-02l423mk	194	22	protons	proton	NOUN
cord-018764-02l423mk	194	23	that	that	PRON
cord-018764-02l423mk	194	24	cause	cause	VERB
cord-018764-02l423mk	194	25	acidosis	acidosis	NOUN
cord-018764-02l423mk	194	26	arise	arise	VERB
cord-018764-02l423mk	194	27	from	from	ADP
cord-018764-02l423mk	194	28	the	the	DET
cord-018764-02l423mk	194	29	hydrolysis	hydrolysis	NOUN
cord-018764-02l423mk	194	30	of	of	ADP
cord-018764-02l423mk	194	31	non	non	ADJ
cord-018764-02l423mk	194	32	-	-	ADJ
cord-018764-02l423mk	194	33	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	194	34	atp	atp	NOUN
cord-018764-02l423mk	194	35	.	.	PUNCT
cord-018764-02l423mk	195	1	since	since	SCONJ
cord-018764-02l423mk	195	2	these	these	DET
cord-018764-02l423mk	195	3	reactions	reaction	NOUN
cord-018764-02l423mk	195	4	are	be	AUX
cord-018764-02l423mk	195	5	independent	independent	ADJ
cord-018764-02l423mk	195	6	of	of	ADP
cord-018764-02l423mk	195	7	lactate	lactate	NOUN
cord-018764-02l423mk	195	8	levels	level	NOUN
cord-018764-02l423mk	195	9	,	,	PUNCT
cord-018764-02l423mk	195	10	it	it	PRON
cord-018764-02l423mk	195	11	is	be	AUX
cord-018764-02l423mk	195	12	difficult	difficult	ADJ
cord-018764-02l423mk	195	13	to	to	PART
cord-018764-02l423mk	195	14	see	see	VERB
cord-018764-02l423mk	195	15	how	how	SCONJ
cord-018764-02l423mk	195	16	therapeutically	therapeutically	ADV
cord-018764-02l423mk	195	17	reducing	reduce	VERB
cord-018764-02l423mk	195	18	levels	level	NOUN
cord-018764-02l423mk	195	19	of	of	ADP
cord-018764-02l423mk	195	20	this	this	DET
cord-018764-02l423mk	195	21	anion	anion	NOUN
cord-018764-02l423mk	195	22	,	,	PUNCT
cord-018764-02l423mk	195	23	as	as	SCONJ
cord-018764-02l423mk	195	24	has	have	AUX
cord-018764-02l423mk	195	25	been	be	AUX
cord-018764-02l423mk	195	26	proposed	propose	VERB
cord-018764-02l423mk	195	27	[	[	X
cord-018764-02l423mk	195	28	125	125	NUM
cord-018764-02l423mk	195	29	]	]	PUNCT
cord-018764-02l423mk	195	30	,	,	PUNCT
cord-018764-02l423mk	195	31	could	could	AUX
cord-018764-02l423mk	195	32	increase	increase	VERB
cord-018764-02l423mk	195	33	survival	survival	NOUN
cord-018764-02l423mk	195	34	rate	rate	NOUN
cord-018764-02l423mk	195	35	in	in	ADP
cord-018764-02l423mk	195	36	falciparum	falciparum	PROPN
cord-018764-02l423mk	195	37	malaria	malaria	NOUN
cord-018764-02l423mk	195	38	any	any	PRON
cord-018764-02l423mk	195	39	more	more	ADJ
cord-018764-02l423mk	195	40	than	than	ADP
cord-018764-02l423mk	195	41	in	in	ADP
cord-018764-02l423mk	195	42	sepsis	sepsis	NOUN
cord-018764-02l423mk	195	43	[	[	X
cord-018764-02l423mk	195	44	126	126	NUM
cord-018764-02l423mk	195	45	]	]	PUNCT
cord-018764-02l423mk	195	46	.	.	PUNCT
cord-018764-02l423mk	196	1	indeed	indeed	ADV
cord-018764-02l423mk	196	2	,	,	PUNCT
cord-018764-02l423mk	196	3	in	in	ADP
cord-018764-02l423mk	196	4	theory	theory	NOUN
cord-018764-02l423mk	196	5	it	it	PRON
cord-018764-02l423mk	196	6	could	could	AUX
cord-018764-02l423mk	196	7	harm	harm	VERB
cord-018764-02l423mk	196	8	comatose	comatose	ADJ
cord-018764-02l423mk	196	9	patients	patient	NOUN
cord-018764-02l423mk	196	10	,	,	PUNCT
cord-018764-02l423mk	196	11	since	since	SCONJ
cord-018764-02l423mk	196	12	there	there	PRON
cord-018764-02l423mk	196	13	is	be	VERB
cord-018764-02l423mk	196	14	evidence	evidence	NOUN
cord-018764-02l423mk	196	15	that	that	SCONJ
cord-018764-02l423mk	196	16	lactate	lactate	NOUN
cord-018764-02l423mk	196	17	helps	help	VERB
cord-018764-02l423mk	196	18	brain	brain	NOUN
cord-018764-02l423mk	196	19	tissue	tissue	NOUN
cord-018764-02l423mk	196	20	survive	survive	VERB
cord-018764-02l423mk	196	21	hypoxic	hypoxic	NOUN
cord-018764-02l423mk	196	22	and	and	CCONJ
cord-018764-02l423mk	196	23	hypoglycaemic	hypoglycaemic	ADJ
cord-018764-02l423mk	196	24	episodes	episode	NOUN
cord-018764-02l423mk	197	1	[	[	X
cord-018764-02l423mk	197	2	127	127	NUM
cord-018764-02l423mk	197	3	]	]	PUNCT
cord-018764-02l423mk	197	4	[	[	X
cord-018764-02l423mk	197	5	128	128	NUM
cord-018764-02l423mk	197	6	]	]	PUNCT
cord-018764-02l423mk	197	7	[	[	X
cord-018764-02l423mk	197	8	129	129	NUM
cord-018764-02l423mk	197	9	]	]	PUNCT
cord-018764-02l423mk	197	10	,	,	PUNCT
cord-018764-02l423mk	197	11	and	and	CCONJ
cord-018764-02l423mk	197	12	the	the	DET
cord-018764-02l423mk	197	13	lactate	lactate	NOUN
cord-018764-02l423mk	197	14	shuttle	shuttle	NOUN
cord-018764-02l423mk	197	15	is	be	AUX
cord-018764-02l423mk	197	16	proving	prove	VERB
cord-018764-02l423mk	197	17	to	to	PART
cord-018764-02l423mk	197	18	be	be	AUX
cord-018764-02l423mk	197	19	how	how	SCONJ
cord-018764-02l423mk	197	20	astrocytes	astrocyte	NOUN
cord-018764-02l423mk	197	21	protect	protect	VERB
cord-018764-02l423mk	197	22	neurons	neuron	NOUN
cord-018764-02l423mk	197	23	from	from	ADP
cord-018764-02l423mk	197	24	metabolic	metabolic	ADJ
cord-018764-02l423mk	197	25	stress	stress	NOUN
cord-018764-02l423mk	197	26	[	[	X
cord-018764-02l423mk	197	27	130	130	NUM
cord-018764-02l423mk	197	28	]	]	PUNCT
cord-018764-02l423mk	197	29	.	.	PUNCT
cord-018764-02l423mk	198	1	even	even	ADV
cord-018764-02l423mk	198	2	when	when	SCONJ
cord-018764-02l423mk	198	3	considerable	considerable	ADJ
cord-018764-02l423mk	198	4	lactate	lactate	NOUN
cord-018764-02l423mk	198	5	is	be	AUX
cord-018764-02l423mk	198	6	generated	generate	VERB
cord-018764-02l423mk	198	7	in	in	ADP
cord-018764-02l423mk	198	8	acute	acute	ADJ
cord-018764-02l423mk	198	9	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	198	10	states	state	NOUN
cord-018764-02l423mk	198	11	,	,	PUNCT
cord-018764-02l423mk	198	12	other	other	ADJ
cord-018764-02l423mk	198	13	,	,	PUNCT
cord-018764-02l423mk	198	14	unidentified	unidentified	ADJ
cord-018764-02l423mk	198	15	,	,	PUNCT
cord-018764-02l423mk	198	16	anions	anion	NOUN
cord-018764-02l423mk	198	17	contribute	contribute	VERB
cord-018764-02l423mk	198	18	much	much	ADV
cord-018764-02l423mk	198	19	more	more	ADJ
cord-018764-02l423mk	198	20	than	than	SCONJ
cord-018764-02l423mk	198	21	it	it	PRON
cord-018764-02l423mk	198	22	does	do	AUX
cord-018764-02l423mk	198	23	to	to	ADP
cord-018764-02l423mk	198	24	the	the	DET
cord-018764-02l423mk	198	25	strong	strong	ADJ
cord-018764-02l423mk	198	26	ion	ion	NOUN
cord-018764-02l423mk	198	27	difference	difference	NOUN
cord-018764-02l423mk	198	28	that	that	PRON
cord-018764-02l423mk	198	29	,	,	PUNCT
cord-018764-02l423mk	198	30	through	through	ADP
cord-018764-02l423mk	198	31	influencing	influence	VERB
cord-018764-02l423mk	198	32	the	the	DET
cord-018764-02l423mk	198	33	body	body	NOUN
cord-018764-02l423mk	198	34	's	's	PART
cord-018764-02l423mk	198	35	buffering	buffering	NOUN
cord-018764-02l423mk	198	36	capacity	capacity	NOUN
cord-018764-02l423mk	198	37	,	,	PUNCT
cord-018764-02l423mk	198	38	influences	influence	VERB
cord-018764-02l423mk	198	39	acidosis	acidosis	NOUN
cord-018764-02l423mk	198	40	in	in	ADP
cord-018764-02l423mk	198	41	sepsis	sepsis	NOUN
cord-018764-02l423mk	198	42	[	[	PUNCT
cord-018764-02l423mk	198	43	131	131	NUM
cord-018764-02l423mk	198	44	,	,	PUNCT
cord-018764-02l423mk	198	45	132	132	NUM
cord-018764-02l423mk	198	46	]	]	PUNCT
cord-018764-02l423mk	198	47	and	and	CCONJ
cord-018764-02l423mk	198	48	falciparum	falciparum	NOUN
cord-018764-02l423mk	198	49	malaria	malaria	NOUN
cord-018764-02l423mk	198	50	[	[	X
cord-018764-02l423mk	198	51	114	114	NUM
cord-018764-02l423mk	198	52	,	,	PUNCT
cord-018764-02l423mk	198	53	133	133	NUM
cord-018764-02l423mk	198	54	]	]	PUNCT
cord-018764-02l423mk	198	55	.	.	PUNCT
cord-018764-02l423mk	199	1	thus	thus	ADV
cord-018764-02l423mk	199	2	,	,	PUNCT
cord-018764-02l423mk	199	3	lactate	lactate	ADJ
cord-018764-02l423mk	199	4	accumulation	accumulation	NOUN
cord-018764-02l423mk	199	5	can	can	AUX
cord-018764-02l423mk	199	6	only	only	ADV
cord-018764-02l423mk	199	7	partially	partially	ADV
cord-018764-02l423mk	199	8	account	account	VERB
cord-018764-02l423mk	199	9	for	for	ADP
cord-018764-02l423mk	199	10	the	the	DET
cord-018764-02l423mk	199	11	high	high	ADJ
cord-018764-02l423mk	199	12	anion	anion	NOUN
cord-018764-02l423mk	199	13	gap	gap	NOUN
cord-018764-02l423mk	199	14	observed	observe	VERB
cord-018764-02l423mk	199	15	during	during	ADP
cord-018764-02l423mk	199	16	the	the	DET
cord-018764-02l423mk	199	17	metabolic	metabolic	ADJ
cord-018764-02l423mk	199	18	acidosis	acidosis	NOUN
cord-018764-02l423mk	199	19	associated	associate	VERB
cord-018764-02l423mk	199	20	with	with	ADP
cord-018764-02l423mk	199	21	severe	severe	ADJ
cord-018764-02l423mk	199	22	malaria	malaria	NOUN
cord-018764-02l423mk	199	23	.	.	PUNCT
cord-018764-02l423mk	200	1	in	in	ADP
cord-018764-02l423mk	200	2	summary	summary	NOUN
cord-018764-02l423mk	200	3	,	,	PUNCT
cord-018764-02l423mk	200	4	lactate	lactate	NOUN
cord-018764-02l423mk	200	5	is	be	AUX
cord-018764-02l423mk	200	6	an	an	DET
cord-018764-02l423mk	200	7	imprecise	imprecise	ADJ
cord-018764-02l423mk	200	8	but	but	CCONJ
cord-018764-02l423mk	200	9	useful	useful	ADJ
cord-018764-02l423mk	200	10	marker	marker	NOUN
cord-018764-02l423mk	200	11	for	for	ADP
cord-018764-02l423mk	200	12	metabolic	metabolic	ADJ
cord-018764-02l423mk	200	13	acidosis	acidosis	NOUN
cord-018764-02l423mk	200	14	in	in	ADP
cord-018764-02l423mk	200	15	malaria	malaria	NOUN
cord-018764-02l423mk	200	16	.	.	PUNCT
cord-018764-02l423mk	201	1	in	in	ADP
cord-018764-02l423mk	201	2	turn	turn	NOUN
cord-018764-02l423mk	201	3	,	,	PUNCT
cord-018764-02l423mk	201	4	acidosis	acidosis	NOUN
cord-018764-02l423mk	201	5	is	be	AUX
cord-018764-02l423mk	201	6	an	an	DET
cord-018764-02l423mk	201	7	imprecise	imprecise	ADJ
cord-018764-02l423mk	201	8	but	but	CCONJ
cord-018764-02l423mk	201	9	useful	useful	ADJ
cord-018764-02l423mk	201	10	marker	marker	NOUN
cord-018764-02l423mk	201	11	of	of	ADP
cord-018764-02l423mk	201	12	impaired	impaired	ADJ
cord-018764-02l423mk	201	13	cellular	cellular	ADJ
cord-018764-02l423mk	201	14	respiration	respiration	NOUN
cord-018764-02l423mk	201	15	.	.	PUNCT
cord-018764-02l423mk	202	1	whether	whether	SCONJ
cord-018764-02l423mk	202	2	impaired	impaired	ADJ
cord-018764-02l423mk	202	3	cellular	cellular	ADJ
cord-018764-02l423mk	202	4	respiration	respiration	NOUN
cord-018764-02l423mk	202	5	arises	arise	VERB
cord-018764-02l423mk	202	6	from	from	ADP
cord-018764-02l423mk	202	7	(	(	PUNCT
cord-018764-02l423mk	202	8	a	a	DET
cord-018764-02l423mk	202	9	)	)	PUNCT
cord-018764-02l423mk	202	10	poor	poor	ADJ
cord-018764-02l423mk	202	11	supply	supply	NOUN
cord-018764-02l423mk	202	12	of	of	ADP
cord-018764-02l423mk	202	13	oxygen	oxygen	NOUN
cord-018764-02l423mk	202	14	to	to	PART
cord-018764-02l423mk	202	15	mitochondria	mitochondria	VERB
cord-018764-02l423mk	202	16	(	(	PUNCT
cord-018764-02l423mk	202	17	through	through	ADP
cord-018764-02l423mk	202	18	vaso	vaso	NOUN
cord-018764-02l423mk	202	19	-	-	PUNCT
cord-018764-02l423mk	202	20	occlusion	occlusion	NOUN
cord-018764-02l423mk	202	21	,	,	PUNCT
cord-018764-02l423mk	202	22	low	low	ADJ
cord-018764-02l423mk	202	23	circulating	circulating	ADJ
cord-018764-02l423mk	202	24	volume	volume	NOUN
cord-018764-02l423mk	202	25	,	,	PUNCT
cord-018764-02l423mk	202	26	anaemia	anaemia	NOUN
cord-018764-02l423mk	202	27	or	or	CCONJ
cord-018764-02l423mk	202	28	cardiac	cardiac	ADJ
cord-018764-02l423mk	202	29	insufficiency	insufficiency	NOUN
cord-018764-02l423mk	202	30	)	)	PUNCT
cord-018764-02l423mk	202	31	or	or	CCONJ
cord-018764-02l423mk	202	32	impaired	impair	VERB
cord-018764-02l423mk	202	33	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	202	34	function	function	NOUN
cord-018764-02l423mk	202	35	(	(	PUNCT
cord-018764-02l423mk	202	36	in	in	ADP
cord-018764-02l423mk	202	37	response	response	NOUN
cord-018764-02l423mk	202	38	to	to	ADP
cord-018764-02l423mk	202	39	severe	severe	ADJ
cord-018764-02l423mk	202	40	systemic	systemic	ADJ
cord-018764-02l423mk	202	41	inflammation	inflammation	NOUN
cord-018764-02l423mk	202	42	)	)	PUNCT
cord-018764-02l423mk	203	1	the	the	DET
cord-018764-02l423mk	203	2	outcome	outcome	NOUN
cord-018764-02l423mk	203	3	is	be	AUX
cord-018764-02l423mk	203	4	essentially	essentially	ADV
cord-018764-02l423mk	203	5	the	the	DET
cord-018764-02l423mk	203	6	same	same	ADJ
cord-018764-02l423mk	203	7	.	.	PUNCT
cord-018764-02l423mk	204	1	the	the	DET
cord-018764-02l423mk	204	2	resulting	result	VERB
cord-018764-02l423mk	204	3	high	high	ADJ
cord-018764-02l423mk	204	4	anion	anion	NOUN
cord-018764-02l423mk	204	5	gap	gap	NOUN
cord-018764-02l423mk	204	6	metabolic	metabolic	ADJ
cord-018764-02l423mk	204	7	acidosis	acidosis	NOUN
cord-018764-02l423mk	204	8	is	be	AUX
cord-018764-02l423mk	204	9	strongly	strongly	ADV
cord-018764-02l423mk	204	10	predictive	predictive	ADJ
cord-018764-02l423mk	204	11	of	of	ADP
cord-018764-02l423mk	204	12	death	death	NOUN
cord-018764-02l423mk	204	13	in	in	ADP
cord-018764-02l423mk	204	14	severe	severe	ADJ
cord-018764-02l423mk	204	15	malaria	malaria	NOUN
cord-018764-02l423mk	204	16	.	.	PUNCT
cord-018764-02l423mk	205	1	greater	great	ADJ
cord-018764-02l423mk	205	2	understanding	understanding	NOUN
cord-018764-02l423mk	205	3	of	of	ADP
cord-018764-02l423mk	205	4	the	the	DET
cord-018764-02l423mk	205	5	multiple	multiple	ADJ
cord-018764-02l423mk	205	6	factors	factor	NOUN
cord-018764-02l423mk	205	7	influencing	influence	VERB
cord-018764-02l423mk	205	8	the	the	DET
cord-018764-02l423mk	205	9	metabolic	metabolic	ADJ
cord-018764-02l423mk	205	10	acidosis	acidosis	NOUN
cord-018764-02l423mk	205	11	could	could	AUX
cord-018764-02l423mk	205	12	provide	provide	VERB
cord-018764-02l423mk	205	13	further	further	ADJ
cord-018764-02l423mk	205	14	insight	insight	NOUN
cord-018764-02l423mk	205	15	into	into	ADP
cord-018764-02l423mk	205	16	the	the	DET
cord-018764-02l423mk	205	17	underlying	underlying	ADJ
cord-018764-02l423mk	205	18	pathophysiological	pathophysiological	ADJ
cord-018764-02l423mk	205	19	process	process	NOUN
cord-018764-02l423mk	205	20	and	and	CCONJ
cord-018764-02l423mk	205	21	may	may	AUX
cord-018764-02l423mk	205	22	provide	provide	VERB
cord-018764-02l423mk	205	23	additional	additional	ADJ
cord-018764-02l423mk	205	24	therapeutic	therapeutic	ADJ
cord-018764-02l423mk	205	25	options	option	NOUN
cord-018764-02l423mk	205	26	.	.	PUNCT
cord-018764-02l423mk	206	1	when	when	SCONJ
cord-018764-02l423mk	206	2	glycolysis	glycolysis	NOUN
cord-018764-02l423mk	206	3	is	be	AUX
cord-018764-02l423mk	206	4	enhanced	enhance	VERB
cord-018764-02l423mk	206	5	for	for	ADP
cord-018764-02l423mk	206	6	any	any	DET
cord-018764-02l423mk	206	7	period	period	NOUN
cord-018764-02l423mk	206	8	glycogen	glycogen	NOUN
cord-018764-02l423mk	206	9	stores	store	NOUN
cord-018764-02l423mk	206	10	are	be	AUX
cord-018764-02l423mk	206	11	soon	soon	ADV
cord-018764-02l423mk	206	12	depleted	deplete	VERB
cord-018764-02l423mk	206	13	,	,	PUNCT
cord-018764-02l423mk	206	14	and	and	CCONJ
cord-018764-02l423mk	206	15	gluconeogenesis	gluconeogenesis	NOUN
cord-018764-02l423mk	206	16	supervenes	supervene	NOUN
cord-018764-02l423mk	206	17	.	.	PUNCT
cord-018764-02l423mk	207	1	however	however	ADV
cord-018764-02l423mk	207	2	,	,	PUNCT
cord-018764-02l423mk	207	3	its	its	PRON
cord-018764-02l423mk	207	4	substrate	substrate	NOUN
cord-018764-02l423mk	207	5	supplies	supply	NOUN
cord-018764-02l423mk	207	6	are	be	AUX
cord-018764-02l423mk	207	7	limiting	limit	VERB
cord-018764-02l423mk	207	8	[	[	X
cord-018764-02l423mk	207	9	134	134	NUM
cord-018764-02l423mk	207	10	]	]	PUNCT
cord-018764-02l423mk	207	11	,	,	PUNCT
cord-018764-02l423mk	207	12	and	and	CCONJ
cord-018764-02l423mk	207	13	the	the	DET
cord-018764-02l423mk	207	14	hypoglycaemia	hypoglycaemia	NOUN
cord-018764-02l423mk	207	15	often	often	ADV
cord-018764-02l423mk	207	16	reported	report	VERB
cord-018764-02l423mk	207	17	in	in	ADP
cord-018764-02l423mk	207	18	severe	severe	ADJ
cord-018764-02l423mk	207	19	malaria	malaria	NOUN
cord-018764-02l423mk	207	20	[	[	PUNCT
cord-018764-02l423mk	207	21	135	135	NUM
cord-018764-02l423mk	207	22	]	]	PUNCT
cord-018764-02l423mk	207	23	and	and	CCONJ
cord-018764-02l423mk	207	24	sepsis	sepsis	NOUN
cord-018764-02l423mk	207	25	[	[	PUNCT
cord-018764-02l423mk	207	26	19	19	NUM
cord-018764-02l423mk	207	27	,	,	PUNCT
cord-018764-02l423mk	207	28	136	136	NUM
cord-018764-02l423mk	207	29	]	]	PUNCT
cord-018764-02l423mk	207	30	occurs	occur	VERB
cord-018764-02l423mk	207	31	.	.	PUNCT
cord-018764-02l423mk	208	1	hypoglycaemia	hypoglycaemia	NOUN
cord-018764-02l423mk	208	2	is	be	AUX
cord-018764-02l423mk	208	3	therefore	therefore	ADV
cord-018764-02l423mk	208	4	a	a	DET
cord-018764-02l423mk	208	5	secondary	secondary	ADJ
cord-018764-02l423mk	208	6	cause	cause	NOUN
cord-018764-02l423mk	208	7	of	of	ADP
cord-018764-02l423mk	208	8	harm	harm	NOUN
cord-018764-02l423mk	208	9	in	in	ADP
cord-018764-02l423mk	208	10	these	these	DET
cord-018764-02l423mk	208	11	diseases	disease	NOUN
cord-018764-02l423mk	208	12	,	,	PUNCT
cord-018764-02l423mk	208	13	and	and	CCONJ
cord-018764-02l423mk	208	14	is	be	AUX
cord-018764-02l423mk	208	15	an	an	DET
cord-018764-02l423mk	208	16	inevitable	inevitable	ADJ
cord-018764-02l423mk	208	17	consequence	consequence	NOUN
cord-018764-02l423mk	208	18	of	of	ADP
cord-018764-02l423mk	208	19	exuberant	exuberant	ADJ
cord-018764-02l423mk	208	20	,	,	PUNCT
cord-018764-02l423mk	208	21	mostly	mostly	ADV
cord-018764-02l423mk	208	22	anaerobic	anaerobic	PROPN
cord-018764-02l423mk	208	23	,	,	PUNCT
cord-018764-02l423mk	208	24	glycolysis	glycolysis	NOUN
cord-018764-02l423mk	208	25	.	.	PUNCT
cord-018764-02l423mk	209	1	cm	cm	PROPN
cord-018764-02l423mk	209	2	is	be	AUX
cord-018764-02l423mk	209	3	a	a	DET
cord-018764-02l423mk	209	4	clinical	clinical	ADJ
cord-018764-02l423mk	209	5	syndrome	syndrome	NOUN
cord-018764-02l423mk	209	6	characterised	characterise	VERB
cord-018764-02l423mk	209	7	by	by	ADP
cord-018764-02l423mk	209	8	coma	coma	PROPN
cord-018764-02l423mk	209	9	(	(	PUNCT
cord-018764-02l423mk	209	10	inability	inability	NOUN
cord-018764-02l423mk	209	11	to	to	PART
cord-018764-02l423mk	209	12	localise	localise	VERB
cord-018764-02l423mk	209	13	a	a	DET
cord-018764-02l423mk	209	14	painful	painful	ADJ
cord-018764-02l423mk	209	15	stimulus	stimulus	NOUN
cord-018764-02l423mk	209	16	)	)	PUNCT
cord-018764-02l423mk	209	17	at	at	ADV
cord-018764-02l423mk	209	18	least	least	ADV
cord-018764-02l423mk	209	19	1	1	NUM
cord-018764-02l423mk	209	20	h	h	NOUN
cord-018764-02l423mk	209	21	after	after	ADP
cord-018764-02l423mk	209	22	termination	termination	NOUN
cord-018764-02l423mk	209	23	of	of	ADP
cord-018764-02l423mk	209	24	a	a	DET
cord-018764-02l423mk	209	25	seizure	seizure	NOUN
cord-018764-02l423mk	209	26	or	or	CCONJ
cord-018764-02l423mk	209	27	correction	correction	NOUN
cord-018764-02l423mk	209	28	of	of	ADP
cord-018764-02l423mk	209	29	hypoglycaemia	hypoglycaemia	NOUN
cord-018764-02l423mk	209	30	,	,	PUNCT
cord-018764-02l423mk	209	31	detection	detection	NOUN
cord-018764-02l423mk	209	32	of	of	ADP
cord-018764-02l423mk	209	33	asexual	asexual	ADJ
cord-018764-02l423mk	209	34	forms	form	NOUN
cord-018764-02l423mk	209	35	of	of	ADP
cord-018764-02l423mk	209	36	p.	p.	NOUN
cord-018764-02l423mk	209	37	falciparum	falciparum	NOUN
cord-018764-02l423mk	209	38	malarial	malarial	ADJ
cord-018764-02l423mk	209	39	parasites	parasite	NOUN
cord-018764-02l423mk	209	40	on	on	ADP
cord-018764-02l423mk	209	41	peripheral	peripheral	ADJ
cord-018764-02l423mk	209	42	blood	blood	NOUN
cord-018764-02l423mk	209	43	smears	smear	NOUN
cord-018764-02l423mk	209	44	,	,	PUNCT
cord-018764-02l423mk	209	45	and	and	CCONJ
cord-018764-02l423mk	209	46	exclusion	exclusion	NOUN
cord-018764-02l423mk	209	47	of	of	ADP
cord-018764-02l423mk	209	48	other	other	ADJ
cord-018764-02l423mk	209	49	causes	cause	NOUN
cord-018764-02l423mk	209	50	of	of	ADP
cord-018764-02l423mk	209	51	encephalopathy	encephalopathy	ADJ
cord-018764-02l423mk	209	52	[	[	X
cord-018764-02l423mk	209	53	137	137	NUM
cord-018764-02l423mk	209	54	]	]	PUNCT
cord-018764-02l423mk	209	55	.	.	PUNCT
cord-018764-02l423mk	210	1	a	a	DET
cord-018764-02l423mk	210	2	relatively	relatively	ADV
cord-018764-02l423mk	210	3	consistent	consistent	ADJ
cord-018764-02l423mk	210	4	feature	feature	NOUN
cord-018764-02l423mk	210	5	of	of	ADP
cord-018764-02l423mk	210	6	acute	acute	ADJ
cord-018764-02l423mk	210	7	cm	cm	NOUN
cord-018764-02l423mk	210	8	in	in	ADP
cord-018764-02l423mk	210	9	children	child	NOUN
cord-018764-02l423mk	210	10	is	be	AUX
cord-018764-02l423mk	210	11	raised	raise	VERB
cord-018764-02l423mk	210	12	intracranial	intracranial	ADJ
cord-018764-02l423mk	210	13	pressure	pressure	NOUN
cord-018764-02l423mk	210	14	(	(	PUNCT
cord-018764-02l423mk	210	15	icp	icp	PROPN
cord-018764-02l423mk	210	16	)	)	PUNCT
cord-018764-02l423mk	210	17	.	.	PUNCT
cord-018764-02l423mk	211	1	studies	study	NOUN
cord-018764-02l423mk	211	2	in	in	ADP
cord-018764-02l423mk	211	3	african	african	ADJ
cord-018764-02l423mk	211	4	children	child	NOUN
cord-018764-02l423mk	211	5	have	have	AUX
cord-018764-02l423mk	211	6	demonstrated	demonstrate	VERB
cord-018764-02l423mk	211	7	a	a	DET
cord-018764-02l423mk	211	8	raised	raise	VERB
cord-018764-02l423mk	211	9	cerebrospinal	cerebrospinal	ADJ
cord-018764-02l423mk	211	10	fluid	fluid	NOUN
cord-018764-02l423mk	211	11	(	(	PUNCT
cord-018764-02l423mk	211	12	csf	csf	NOUN
cord-018764-02l423mk	211	13	)	)	PUNCT
cord-018764-02l423mk	211	14	opening	opening	NOUN
cord-018764-02l423mk	211	15	pressure	pressure	NOUN
cord-018764-02l423mk	211	16	during	during	ADP
cord-018764-02l423mk	211	17	lumbar	lumbar	NOUN
cord-018764-02l423mk	211	18	puncture	puncture	NOUN
cord-018764-02l423mk	211	19	in	in	ADP
cord-018764-02l423mk	211	20	80	80	NUM
cord-018764-02l423mk	211	21	%	%	NOUN
cord-018764-02l423mk	211	22	of	of	ADP
cord-018764-02l423mk	211	23	cm	cm	PROPN
cord-018764-02l423mk	211	24	children	child	NOUN
cord-018764-02l423mk	211	25	[	[	X
cord-018764-02l423mk	211	26	138	138	NUM
cord-018764-02l423mk	211	27	]	]	PUNCT
cord-018764-02l423mk	211	28	,	,	PUNCT
cord-018764-02l423mk	211	29	raised	raise	VERB
cord-018764-02l423mk	211	30	icp	icp	PROPN
cord-018764-02l423mk	211	31	during	during	ADP
cord-018764-02l423mk	211	32	intracranial	intracranial	ADJ
cord-018764-02l423mk	211	33	pressure	pressure	NOUN
cord-018764-02l423mk	211	34	monitoring	monitoring	NOUN
cord-018764-02l423mk	211	35	(	(	PUNCT
cord-018764-02l423mk	211	36	23/23	23/23	NUM
cord-018764-02l423mk	211	37	icp	icp	X
cord-018764-02l423mk	211	38	>	>	SYM
cord-018764-02l423mk	211	39	10	10	NUM
cord-018764-02l423mk	211	40	mmhg	mmhg	NOUN
cord-018764-02l423mk	211	41	)	)	PUNCT
cord-018764-02l423mk	212	1	[	[	PUNCT
cord-018764-02l423mk	212	2	139	139	NUM
cord-018764-02l423mk	212	3	]	]	PUNCT
cord-018764-02l423mk	212	4	and	and	CCONJ
cord-018764-02l423mk	212	5	papilloedema	papilloedema	NOUN
cord-018764-02l423mk	212	6	(	(	PUNCT
cord-018764-02l423mk	212	7	a	a	DET
cord-018764-02l423mk	212	8	late	late	ADJ
cord-018764-02l423mk	212	9	sign	sign	NOUN
cord-018764-02l423mk	212	10	of	of	ADP
cord-018764-02l423mk	212	11	raised	raise	VERB
cord-018764-02l423mk	212	12	icp	icp	PROPN
cord-018764-02l423mk	212	13	)	)	PUNCT
cord-018764-02l423mk	212	14	in	in	ADP
cord-018764-02l423mk	212	15	44	44	NUM
cord-018764-02l423mk	212	16	%	%	NOUN
cord-018764-02l423mk	212	17	of	of	ADP
cord-018764-02l423mk	212	18	cm	cm	PROPN
cord-018764-02l423mk	212	19	patients	patient	NOUN
cord-018764-02l423mk	212	20	who	who	PRON
cord-018764-02l423mk	212	21	died	die	VERB
cord-018764-02l423mk	212	22	[	[	X
cord-018764-02l423mk	212	23	140	140	NUM
cord-018764-02l423mk	212	24	]	]	PUNCT
cord-018764-02l423mk	212	25	.	.	PUNCT
cord-018764-02l423mk	213	1	where	where	SCONJ
cord-018764-02l423mk	213	2	computer	computer	NOUN
cord-018764-02l423mk	213	3	tomography	tomography	NOUN
cord-018764-02l423mk	213	4	has	have	AUX
cord-018764-02l423mk	213	5	been	be	AUX
cord-018764-02l423mk	213	6	performed	perform	VERB
cord-018764-02l423mk	213	7	,	,	PUNCT
cord-018764-02l423mk	213	8	there	there	PRON
cord-018764-02l423mk	213	9	was	be	VERB
cord-018764-02l423mk	213	10	evidence	evidence	NOUN
cord-018764-02l423mk	213	11	of	of	ADP
cord-018764-02l423mk	213	12	diffuse	diffuse	NOUN
cord-018764-02l423mk	213	13	brain	brain	NOUN
cord-018764-02l423mk	213	14	swelling	swell	VERB
cord-018764-02l423mk	213	15	in	in	ADP
cord-018764-02l423mk	213	16	40	40	NUM
cord-018764-02l423mk	213	17	%	%	NOUN
cord-018764-02l423mk	213	18	of	of	ADP
cord-018764-02l423mk	213	19	patients	patient	NOUN
cord-018764-02l423mk	213	20	[	[	X
cord-018764-02l423mk	213	21	139	139	NUM
cord-018764-02l423mk	213	22	]	]	PUNCT
cord-018764-02l423mk	213	23	.	.	PUNCT
cord-018764-02l423mk	214	1	the	the	DET
cord-018764-02l423mk	214	2	cause	cause	NOUN
cord-018764-02l423mk	214	3	of	of	ADP
cord-018764-02l423mk	214	4	the	the	DET
cord-018764-02l423mk	214	5	raised	raise	VERB
cord-018764-02l423mk	214	6	icp	icp	PROPN
cord-018764-02l423mk	214	7	is	be	AUX
cord-018764-02l423mk	214	8	likely	likely	ADJ
cord-018764-02l423mk	214	9	to	to	PART
cord-018764-02l423mk	214	10	be	be	AUX
cord-018764-02l423mk	214	11	multi	multi	ADJ
cord-018764-02l423mk	214	12	-	-	ADJ
cord-018764-02l423mk	214	13	factorial	factorial	ADJ
cord-018764-02l423mk	214	14	and	and	CCONJ
cord-018764-02l423mk	214	15	has	have	AUX
cord-018764-02l423mk	214	16	been	be	AUX
cord-018764-02l423mk	214	17	postulated	postulate	VERB
cord-018764-02l423mk	214	18	to	to	PART
cord-018764-02l423mk	214	19	involve	involve	VERB
cord-018764-02l423mk	214	20	both	both	DET
cord-018764-02l423mk	214	21	vasogenic	vasogenic	ADJ
cord-018764-02l423mk	214	22	and	and	CCONJ
cord-018764-02l423mk	214	23	cytotoxic	cytotoxic	ADJ
cord-018764-02l423mk	214	24	patterns	pattern	NOUN
cord-018764-02l423mk	214	25	of	of	ADP
cord-018764-02l423mk	214	26	cerebral	cerebral	ADJ
cord-018764-02l423mk	214	27	oedema	oedema	PROPN
cord-018764-02l423mk	214	28	.	.	PUNCT
cord-018764-02l423mk	215	1	vasogenic	vasogenic	PROPN
cord-018764-02l423mk	215	2	oedema	oedema	PROPN
cord-018764-02l423mk	215	3	is	be	AUX
cord-018764-02l423mk	215	4	characterised	characterise	VERB
cord-018764-02l423mk	215	5	by	by	ADP
cord-018764-02l423mk	215	6	accumulation	accumulation	NOUN
cord-018764-02l423mk	215	7	of	of	ADP
cord-018764-02l423mk	215	8	interstitial	interstitial	ADJ
cord-018764-02l423mk	215	9	fluid	fluid	NOUN
cord-018764-02l423mk	215	10	within	within	ADP
cord-018764-02l423mk	215	11	the	the	DET
cord-018764-02l423mk	215	12	brain	brain	NOUN
cord-018764-02l423mk	215	13	secondary	secondary	ADJ
cord-018764-02l423mk	215	14	to	to	ADP
cord-018764-02l423mk	215	15	increased	increase	VERB
cord-018764-02l423mk	215	16	permeability	permeability	NOUN
cord-018764-02l423mk	215	17	of	of	ADP
cord-018764-02l423mk	215	18	the	the	DET
cord-018764-02l423mk	215	19	blood	blood	NOUN
cord-018764-02l423mk	215	20	-	-	PUNCT
cord-018764-02l423mk	215	21	brain	brain	NOUN
cord-018764-02l423mk	215	22	barrier	barrier	NOUN
cord-018764-02l423mk	215	23	(	(	PUNCT
cord-018764-02l423mk	215	24	bbb	bbb	PROPN
cord-018764-02l423mk	215	25	)	)	PUNCT
cord-018764-02l423mk	215	26	.	.	PUNCT
cord-018764-02l423mk	216	1	it	it	PRON
cord-018764-02l423mk	216	2	has	have	AUX
cord-018764-02l423mk	216	3	been	be	AUX
cord-018764-02l423mk	216	4	demonstrated	demonstrate	VERB
cord-018764-02l423mk	216	5	in	in	ADP
cord-018764-02l423mk	216	6	bacterial	bacterial	ADJ
cord-018764-02l423mk	216	7	cerebral	cerebral	ADJ
cord-018764-02l423mk	216	8	infections	infection	NOUN
cord-018764-02l423mk	216	9	,	,	PUNCT
cord-018764-02l423mk	216	10	but	but	CCONJ
cord-018764-02l423mk	216	11	evidence	evidence	NOUN
cord-018764-02l423mk	216	12	of	of	ADP
cord-018764-02l423mk	216	13	significant	significant	ADJ
cord-018764-02l423mk	216	14	disruption	disruption	NOUN
cord-018764-02l423mk	216	15	of	of	ADP
cord-018764-02l423mk	216	16	the	the	DET
cord-018764-02l423mk	216	17	bbb	bbb	PROPN
cord-018764-02l423mk	216	18	is	be	AUX
cord-018764-02l423mk	216	19	not	not	PART
cord-018764-02l423mk	216	20	conclusive	conclusive	ADJ
cord-018764-02l423mk	216	21	in	in	ADP
cord-018764-02l423mk	216	22	cm	cm	NOUN
cord-018764-02l423mk	217	1	[	[	PUNCT
cord-018764-02l423mk	217	2	141	141	NUM
cord-018764-02l423mk	217	3	]	]	PUNCT
cord-018764-02l423mk	217	4	.	.	PUNCT
cord-018764-02l423mk	218	1	others	other	NOUN
cord-018764-02l423mk	218	2	have	have	AUX
cord-018764-02l423mk	218	3	proposed	propose	VERB
cord-018764-02l423mk	218	4	that	that	SCONJ
cord-018764-02l423mk	218	5	icam-1	icam-1	PRON
cord-018764-02l423mk	218	6	binding	bind	VERB
cord-018764-02l423mk	218	7	by	by	ADP
cord-018764-02l423mk	218	8	infected	infected	ADJ
cord-018764-02l423mk	218	9	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	218	10	may	may	AUX
cord-018764-02l423mk	218	11	generate	generate	VERB
cord-018764-02l423mk	218	12	a	a	DET
cord-018764-02l423mk	218	13	cascade	cascade	NOUN
cord-018764-02l423mk	218	14	of	of	ADP
cord-018764-02l423mk	218	15	intracellular	intracellular	ADJ
cord-018764-02l423mk	218	16	signalling	signal	VERB
cord-018764-02l423mk	218	17	events	event	NOUN
cord-018764-02l423mk	218	18	that	that	PRON
cord-018764-02l423mk	218	19	disrupt	disrupt	VERB
cord-018764-02l423mk	218	20	the	the	DET
cord-018764-02l423mk	218	21	cytoskeletal	cytoskeletal	ADJ
cord-018764-02l423mk	218	22	-	-	PUNCT
cord-018764-02l423mk	218	23	cell	cell	NOUN
cord-018764-02l423mk	218	24	junction	junction	NOUN
cord-018764-02l423mk	218	25	structure	structure	NOUN
cord-018764-02l423mk	218	26	and	and	CCONJ
cord-018764-02l423mk	218	27	cause	cause	VERB
cord-018764-02l423mk	218	28	focal	focal	ADJ
cord-018764-02l423mk	218	29	disruption	disruption	NOUN
cord-018764-02l423mk	218	30	to	to	ADP
cord-018764-02l423mk	218	31	the	the	DET
cord-018764-02l423mk	218	32	bbb	bbb	PROPN
cord-018764-02l423mk	219	1	[	[	PUNCT
cord-018764-02l423mk	219	2	142	142	NUM
cord-018764-02l423mk	219	3	]	]	PUNCT
cord-018764-02l423mk	219	4	.	.	PUNCT
cord-018764-02l423mk	220	1	adult	adult	PROPN
cord-018764-02l423mk	220	2	post	post	ADJ
cord-018764-02l423mk	220	3	-	-	ADJ
cord-018764-02l423mk	220	4	mortem	mortem	ADJ
cord-018764-02l423mk	220	5	analysis	analysis	NOUN
cord-018764-02l423mk	220	6	has	have	AUX
cord-018764-02l423mk	220	7	shown	show	VERB
cord-018764-02l423mk	220	8	cerebrovascular	cerebrovascular	ADJ
cord-018764-02l423mk	220	9	endothelial	endothelial	ADJ
cord-018764-02l423mk	220	10	cell	cell	NOUN
cord-018764-02l423mk	220	11	activation	activation	NOUN
cord-018764-02l423mk	220	12	(	(	PUNCT
cord-018764-02l423mk	220	13	increased	increase	VERB
cord-018764-02l423mk	220	14	icam-1	icam-1	NUM
cord-018764-02l423mk	220	15	endothelial	endothelial	ADJ
cord-018764-02l423mk	220	16	staining	staining	NOUN
cord-018764-02l423mk	220	17	,	,	PUNCT
cord-018764-02l423mk	220	18	reduction	reduction	NOUN
cord-018764-02l423mk	220	19	in	in	ADP
cord-018764-02l423mk	220	20	cell	cell	NOUN
cord-018764-02l423mk	220	21	junction	junction	NOUN
cord-018764-02l423mk	220	22	staining	staining	NOUN
cord-018764-02l423mk	220	23	,	,	PUNCT
cord-018764-02l423mk	220	24	and	and	CCONJ
cord-018764-02l423mk	220	25	disruption	disruption	NOUN
cord-018764-02l423mk	220	26	of	of	ADP
cord-018764-02l423mk	220	27	junction	junction	NOUN
cord-018764-02l423mk	220	28	proteins	protein	NOUN
cord-018764-02l423mk	220	29	)	)	PUNCT
cord-018764-02l423mk	220	30	,	,	PUNCT
cord-018764-02l423mk	220	31	particularly	particularly	ADV
cord-018764-02l423mk	220	32	in	in	ADP
cord-018764-02l423mk	220	33	vessels	vessel	NOUN
cord-018764-02l423mk	220	34	containing	contain	VERB
cord-018764-02l423mk	220	35	infected	infected	ADJ
cord-018764-02l423mk	220	36	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	221	1	[	[	X
cord-018764-02l423mk	221	2	143	143	NUM
cord-018764-02l423mk	221	3	]	]	PUNCT
cord-018764-02l423mk	221	4	.	.	PUNCT
cord-018764-02l423mk	222	1	however	however	ADV
cord-018764-02l423mk	222	2	,	,	PUNCT
cord-018764-02l423mk	222	3	disruption	disruption	NOUN
cord-018764-02l423mk	222	4	of	of	ADP
cord-018764-02l423mk	222	5	intercellular	intercellular	ADJ
cord-018764-02l423mk	222	6	junctions	junction	NOUN
cord-018764-02l423mk	222	7	is	be	AUX
cord-018764-02l423mk	222	8	not	not	PART
cord-018764-02l423mk	222	9	associated	associate	VERB
cord-018764-02l423mk	222	10	with	with	ADP
cord-018764-02l423mk	222	11	significant	significant	ADJ
cord-018764-02l423mk	222	12	leakage	leakage	NOUN
cord-018764-02l423mk	222	13	of	of	ADP
cord-018764-02l423mk	222	14	plasma	plasma	NOUN
cord-018764-02l423mk	222	15	proteins	protein	NOUN
cord-018764-02l423mk	222	16	(	(	PUNCT
cord-018764-02l423mk	222	17	fibrinogen	fibrinogen	PROPN
cord-018764-02l423mk	222	18	,	,	PUNCT
cord-018764-02l423mk	222	19	igg	igg	PROPN
cord-018764-02l423mk	222	20	,	,	PUNCT
cord-018764-02l423mk	222	21	or	or	CCONJ
cord-018764-02l423mk	222	22	c5b-9	c5b-9	ADJ
cord-018764-02l423mk	222	23	)	)	PUNCT
cord-018764-02l423mk	222	24	into	into	ADP
cord-018764-02l423mk	222	25	perivascular	perivascular	ADJ
cord-018764-02l423mk	222	26	areas	area	NOUN
cord-018764-02l423mk	222	27	or	or	CCONJ
cord-018764-02l423mk	222	28	csf	csf	NOUN
cord-018764-02l423mk	222	29	[	[	X
cord-018764-02l423mk	222	30	143	143	NUM
cord-018764-02l423mk	222	31	]	]	PUNCT
cord-018764-02l423mk	222	32	.	.	PUNCT
cord-018764-02l423mk	223	1	in	in	ADP
cord-018764-02l423mk	223	2	thai	thai	ADJ
cord-018764-02l423mk	223	3	adults	adult	NOUN
cord-018764-02l423mk	223	4	,	,	PUNCT
cord-018764-02l423mk	223	5	transfer	transfer	NOUN
cord-018764-02l423mk	223	6	of	of	ADP
cord-018764-02l423mk	223	7	radioactively	radioactively	ADV
cord-018764-02l423mk	223	8	labelled	label	VERB
cord-018764-02l423mk	223	9	albumin	albumin	NOUN
cord-018764-02l423mk	223	10	into	into	ADP
cord-018764-02l423mk	223	11	csf	csf	NOUN
cord-018764-02l423mk	223	12	was	be	AUX
cord-018764-02l423mk	223	13	not	not	PART
cord-018764-02l423mk	223	14	raised	raise	VERB
cord-018764-02l423mk	223	15	during	during	ADP
cord-018764-02l423mk	223	16	unconsciousness	unconsciousness	NOUN
cord-018764-02l423mk	223	17	compared	compare	VERB
cord-018764-02l423mk	223	18	with	with	ADP
cord-018764-02l423mk	223	19	convalescence	convalescence	NOUN
cord-018764-02l423mk	224	1	[	[	PUNCT
cord-018764-02l423mk	224	2	144	144	NUM
cord-018764-02l423mk	224	3	]	]	PUNCT
cord-018764-02l423mk	224	4	.	.	PUNCT
cord-018764-02l423mk	225	1	similarly	similarly	ADV
cord-018764-02l423mk	225	2	,	,	PUNCT
cord-018764-02l423mk	225	3	the	the	DET
cord-018764-02l423mk	225	4	albumin	albumin	NOUN
cord-018764-02l423mk	225	5	index	index	NOUN
cord-018764-02l423mk	225	6	(	(	PUNCT
cord-018764-02l423mk	225	7	ratio	ratio	NOUN
cord-018764-02l423mk	225	8	of	of	ADP
cord-018764-02l423mk	225	9	concentrations	concentration	NOUN
cord-018764-02l423mk	225	10	of	of	ADP
cord-018764-02l423mk	225	11	albumin	albumin	NOUN
cord-018764-02l423mk	225	12	in	in	ADP
cord-018764-02l423mk	225	13	csf	csf	NOUN
cord-018764-02l423mk	225	14	to	to	ADP
cord-018764-02l423mk	225	15	those	those	PRON
cord-018764-02l423mk	225	16	in	in	ADP
cord-018764-02l423mk	225	17	blood	blood	NOUN
cord-018764-02l423mk	225	18	)	)	PUNCT
cord-018764-02l423mk	225	19	was	be	AUX
cord-018764-02l423mk	225	20	not	not	PART
cord-018764-02l423mk	225	21	altered	alter	VERB
cord-018764-02l423mk	225	22	significantly	significantly	ADV
cord-018764-02l423mk	225	23	in	in	ADP
cord-018764-02l423mk	225	24	vietnamese	vietnamese	ADJ
cord-018764-02l423mk	225	25	adults	adult	NOUN
cord-018764-02l423mk	225	26	[	[	X
cord-018764-02l423mk	225	27	145	145	NUM
cord-018764-02l423mk	225	28	]	]	PUNCT
cord-018764-02l423mk	225	29	or	or	CCONJ
cord-018764-02l423mk	225	30	significantly	significantly	ADV
cord-018764-02l423mk	225	31	different	different	ADJ
cord-018764-02l423mk	225	32	between	between	ADP
cord-018764-02l423mk	225	33	malawian	malawian	ADJ
cord-018764-02l423mk	225	34	children	child	NOUN
cord-018764-02l423mk	225	35	with	with	ADP
cord-018764-02l423mk	225	36	cm	cm	NOUN
cord-018764-02l423mk	225	37	who	who	PRON
cord-018764-02l423mk	225	38	died	die	VERB
cord-018764-02l423mk	225	39	and	and	CCONJ
cord-018764-02l423mk	225	40	those	those	PRON
cord-018764-02l423mk	225	41	who	who	PRON
cord-018764-02l423mk	225	42	survived	survive	VERB
cord-018764-02l423mk	225	43	[	[	X
cord-018764-02l423mk	225	44	143	143	NUM
cord-018764-02l423mk	225	45	]	]	PUNCT
cord-018764-02l423mk	225	46	.	.	PUNCT
cord-018764-02l423mk	226	1	cytotoxic	cytotoxic	NOUN
cord-018764-02l423mk	226	2	oedema	oedema	PROPN
cord-018764-02l423mk	226	3	is	be	AUX
cord-018764-02l423mk	226	4	increasingly	increasingly	ADV
cord-018764-02l423mk	226	5	being	be	AUX
cord-018764-02l423mk	226	6	recognised	recognise	VERB
cord-018764-02l423mk	226	7	as	as	ADP
cord-018764-02l423mk	226	8	an	an	DET
cord-018764-02l423mk	226	9	important	important	ADJ
cord-018764-02l423mk	226	10	mechanism	mechanism	NOUN
cord-018764-02l423mk	226	11	of	of	ADP
cord-018764-02l423mk	226	12	cerebral	cerebral	ADJ
cord-018764-02l423mk	226	13	oedema	oedema	NOUN
cord-018764-02l423mk	226	14	in	in	ADP
cord-018764-02l423mk	226	15	traumatic	traumatic	ADJ
cord-018764-02l423mk	226	16	brain	brain	NOUN
cord-018764-02l423mk	226	17	injury	injury	NOUN
cord-018764-02l423mk	226	18	[	[	PUNCT
cord-018764-02l423mk	226	19	146	146	NUM
cord-018764-02l423mk	226	20	]	]	PUNCT
cord-018764-02l423mk	226	21	.	.	PUNCT
cord-018764-02l423mk	227	1	as	as	SCONJ
cord-018764-02l423mk	227	2	previously	previously	ADV
cord-018764-02l423mk	227	3	discussed	discuss	VERB
cord-018764-02l423mk	227	4	,	,	PUNCT
cord-018764-02l423mk	227	5	this	this	DET
cord-018764-02l423mk	227	6	type	type	NOUN
cord-018764-02l423mk	227	7	of	of	ADP
cord-018764-02l423mk	227	8	cell	cell	NOUN
cord-018764-02l423mk	227	9	swelling	swelling	NOUN
cord-018764-02l423mk	227	10	involves	involve	VERB
cord-018764-02l423mk	227	11	disturbance	disturbance	NOUN
cord-018764-02l423mk	227	12	of	of	ADP
cord-018764-02l423mk	227	13	the	the	DET
cord-018764-02l423mk	227	14	"	"	PUNCT
cord-018764-02l423mk	227	15	pumpleak	pumpleak	PROPN
cord-018764-02l423mk	227	16	equilibrium	equilibrium	NOUN
cord-018764-02l423mk	227	17	"	"	PUNCT
cord-018764-02l423mk	227	18	maintained	maintain	VERB
cord-018764-02l423mk	227	19	,	,	PUNCT
cord-018764-02l423mk	227	20	under	under	ADP
cord-018764-02l423mk	227	21	physiological	physiological	ADJ
cord-018764-02l423mk	227	22	conditions	condition	NOUN
cord-018764-02l423mk	227	23	via	via	ADP
cord-018764-02l423mk	227	24	active	active	ADJ
cord-018764-02l423mk	227	25	elimination	elimination	NOUN
cord-018764-02l423mk	227	26	of	of	ADP
cord-018764-02l423mk	227	27	osmotically	osmotically	ADV
cord-018764-02l423mk	227	28	active	active	ADJ
cord-018764-02l423mk	227	29	solutes	solute	NOUN
cord-018764-02l423mk	227	30	through	through	ADP
cord-018764-02l423mk	227	31	the	the	DET
cord-018764-02l423mk	227	32	energy	energy	NOUN
cord-018764-02l423mk	227	33	-	-	PUNCT
cord-018764-02l423mk	227	34	dependent	dependent	ADJ
cord-018764-02l423mk	227	35	na	na	ADP
cord-018764-02l423mk	227	36	+	+	CCONJ
cord-018764-02l423mk	227	37	/k	/k	PUNCT
cord-018764-02l423mk	228	1	+	+	X
cord-018764-02l423mk	228	2	-atpase	-atpase	NOUN
cord-018764-02l423mk	228	3	.	.	PUNCT
cord-018764-02l423mk	229	1	thus	thus	ADV
cord-018764-02l423mk	229	2	,	,	PUNCT
cord-018764-02l423mk	229	3	cytotoxic	cytotoxic	PROPN
cord-018764-02l423mk	229	4	oedema	oedema	NOUN
cord-018764-02l423mk	229	5	can	can	AUX
cord-018764-02l423mk	229	6	occur	occur	VERB
cord-018764-02l423mk	229	7	secondary	secondary	ADJ
cord-018764-02l423mk	229	8	to	to	ADP
cord-018764-02l423mk	229	9	an	an	DET
cord-018764-02l423mk	229	10	imbalance	imbalance	NOUN
cord-018764-02l423mk	229	11	in	in	ADP
cord-018764-02l423mk	229	12	supply	supply	NOUN
cord-018764-02l423mk	229	13	and	and	CCONJ
cord-018764-02l423mk	229	14	demand	demand	NOUN
cord-018764-02l423mk	229	15	of	of	ADP
cord-018764-02l423mk	229	16	energy	energy	NOUN
cord-018764-02l423mk	229	17	within	within	ADP
cord-018764-02l423mk	229	18	the	the	DET
cord-018764-02l423mk	229	19	cells	cell	NOUN
cord-018764-02l423mk	229	20	.	.	PUNCT
cord-018764-02l423mk	230	1	several	several	ADJ
cord-018764-02l423mk	230	2	mechanisms	mechanism	NOUN
cord-018764-02l423mk	230	3	,	,	PUNCT
cord-018764-02l423mk	230	4	such	such	ADJ
cord-018764-02l423mk	230	5	as	as	ADP
cord-018764-02l423mk	230	6	sustained	sustained	ADJ
cord-018764-02l423mk	230	7	increase	increase	NOUN
cord-018764-02l423mk	230	8	in	in	ADP
cord-018764-02l423mk	230	9	neuronal	neuronal	ADJ
cord-018764-02l423mk	230	10	activation	activation	NOUN
cord-018764-02l423mk	230	11	,	,	PUNCT
cord-018764-02l423mk	230	12	impaired	impaired	ADJ
cord-018764-02l423mk	230	13	substrate	substrate	NOUN
cord-018764-02l423mk	230	14	delivery	delivery	NOUN
cord-018764-02l423mk	230	15	(	(	PUNCT
cord-018764-02l423mk	230	16	structural	structural	ADJ
cord-018764-02l423mk	230	17	and	and	CCONJ
cord-018764-02l423mk	230	18	functional	functional	ADJ
cord-018764-02l423mk	230	19	)	)	PUNCT
cord-018764-02l423mk	230	20	and	and	CCONJ
cord-018764-02l423mk	230	21	impaired	impaired	ADJ
cord-018764-02l423mk	230	22	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	230	23	utilisation	utilisation	NOUN
cord-018764-02l423mk	230	24	of	of	ADP
cord-018764-02l423mk	230	25	available	available	ADJ
cord-018764-02l423mk	230	26	substrates	substrate	NOUN
cord-018764-02l423mk	230	27	,	,	PUNCT
cord-018764-02l423mk	230	28	including	include	VERB
cord-018764-02l423mk	230	29	oxygen	oxygen	NOUN
cord-018764-02l423mk	230	30	,	,	PUNCT
cord-018764-02l423mk	230	31	may	may	AUX
cord-018764-02l423mk	230	32	coexist	coexist	VERB
cord-018764-02l423mk	230	33	to	to	PART
cord-018764-02l423mk	230	34	generate	generate	VERB
cord-018764-02l423mk	230	35	this	this	DET
cord-018764-02l423mk	230	36	imbalance	imbalance	NOUN
cord-018764-02l423mk	230	37	.	.	PUNCT
cord-018764-02l423mk	231	1	all	all	DET
cord-018764-02l423mk	231	2	these	these	DET
cord-018764-02l423mk	231	3	mechanisms	mechanism	NOUN
cord-018764-02l423mk	231	4	could	could	AUX
cord-018764-02l423mk	231	5	contribute	contribute	VERB
cord-018764-02l423mk	231	6	to	to	ADP
cord-018764-02l423mk	231	7	atp	atp	NOUN
cord-018764-02l423mk	231	8	depletion	depletion	NOUN
cord-018764-02l423mk	231	9	and	and	CCONJ
cord-018764-02l423mk	231	10	na	na	ADP
cord-018764-02l423mk	231	11	+	+	CCONJ
cord-018764-02l423mk	231	12	/k	/k	PUNCT
cord-018764-02l423mk	232	1	+	+	SYM
cord-018764-02l423mk	233	1	atpase	atpase	NOUN
cord-018764-02l423mk	233	2	failure	failure	NOUN
cord-018764-02l423mk	233	3	,	,	PUNCT
cord-018764-02l423mk	233	4	leading	lead	VERB
cord-018764-02l423mk	233	5	to	to	ADP
cord-018764-02l423mk	233	6	cytotoxic	cytotoxic	ADJ
cord-018764-02l423mk	233	7	oedema	oedema	NOUN
cord-018764-02l423mk	233	8	in	in	ADP
cord-018764-02l423mk	233	9	cm	cm	PROPN
cord-018764-02l423mk	233	10	.	.	PUNCT
cord-018764-02l423mk	234	1	cm	cm	PROPN
cord-018764-02l423mk	234	2	is	be	AUX
cord-018764-02l423mk	234	3	clearly	clearly	ADV
cord-018764-02l423mk	234	4	associated	associate	VERB
cord-018764-02l423mk	234	5	with	with	ADP
cord-018764-02l423mk	234	6	increased	increase	VERB
cord-018764-02l423mk	234	7	neuronal	neuronal	ADJ
cord-018764-02l423mk	234	8	activity	activity	NOUN
cord-018764-02l423mk	234	9	.	.	PUNCT
cord-018764-02l423mk	235	1	a	a	DET
cord-018764-02l423mk	235	2	recent	recent	ADJ
cord-018764-02l423mk	235	3	review	review	NOUN
cord-018764-02l423mk	235	4	identified	identify	VERB
cord-018764-02l423mk	235	5	that	that	SCONJ
cord-018764-02l423mk	235	6	80	80	NUM
cord-018764-02l423mk	235	7	%	%	NOUN
cord-018764-02l423mk	235	8	of	of	ADP
cord-018764-02l423mk	235	9	african	african	ADJ
cord-018764-02l423mk	235	10	children	child	NOUN
cord-018764-02l423mk	235	11	with	with	ADP
cord-018764-02l423mk	235	12	cm	cm	NOUN
cord-018764-02l423mk	235	13	have	have	VERB
cord-018764-02l423mk	235	14	a	a	DET
cord-018764-02l423mk	235	15	history	history	NOUN
cord-018764-02l423mk	235	16	of	of	ADP
cord-018764-02l423mk	235	17	seizures	seizure	NOUN
cord-018764-02l423mk	235	18	,	,	PUNCT
cord-018764-02l423mk	235	19	with	with	ADP
cord-018764-02l423mk	235	20	prolonged	prolonged	ADJ
cord-018764-02l423mk	235	21	and	and	CCONJ
cord-018764-02l423mk	235	22	recurrent	recurrent	ADJ
cord-018764-02l423mk	235	23	seizures	seizure	NOUN
cord-018764-02l423mk	235	24	associated	associate	VERB
cord-018764-02l423mk	235	25	with	with	ADP
cord-018764-02l423mk	235	26	a	a	DET
cord-018764-02l423mk	235	27	poor	poor	ADJ
cord-018764-02l423mk	235	28	outcome	outcome	NOUN
cord-018764-02l423mk	235	29	[	[	X
cord-018764-02l423mk	235	30	147	147	NUM
cord-018764-02l423mk	235	31	]	]	PUNCT
cord-018764-02l423mk	235	32	.	.	PUNCT
cord-018764-02l423mk	236	1	impaired	impair	VERB
cord-018764-02l423mk	236	2	vascular	vascular	NOUN
cord-018764-02l423mk	236	3	flow	flow	NOUN
cord-018764-02l423mk	236	4	during	during	ADP
cord-018764-02l423mk	236	5	acute	acute	ADJ
cord-018764-02l423mk	236	6	cm	cm	PROPN
cord-018764-02l423mk	236	7	may	may	AUX
cord-018764-02l423mk	236	8	limit	limit	VERB
cord-018764-02l423mk	236	9	substrate	substrate	ADJ
cord-018764-02l423mk	236	10	delivery	delivery	NOUN
cord-018764-02l423mk	236	11	within	within	ADP
cord-018764-02l423mk	236	12	the	the	DET
cord-018764-02l423mk	236	13	brain	brain	NOUN
cord-018764-02l423mk	236	14	and	and	CCONJ
cord-018764-02l423mk	236	15	contribute	contribute	VERB
cord-018764-02l423mk	236	16	to	to	ADP
cord-018764-02l423mk	236	17	energy	energy	NOUN
cord-018764-02l423mk	236	18	imbalance	imbalance	NOUN
cord-018764-02l423mk	236	19	.	.	PUNCT
cord-018764-02l423mk	237	1	in	in	ADP
cord-018764-02l423mk	237	2	the	the	DET
cord-018764-02l423mk	237	3	past	past	NOUN
cord-018764-02l423mk	237	4	,	,	PUNCT
cord-018764-02l423mk	237	5	a	a	DET
cord-018764-02l423mk	237	6	common	common	ADJ
cord-018764-02l423mk	237	7	premise	premise	NOUN
cord-018764-02l423mk	237	8	was	be	AUX
cord-018764-02l423mk	237	9	that	that	SCONJ
cord-018764-02l423mk	237	10	parasite	parasite	ADJ
cord-018764-02l423mk	237	11	sequestration	sequestration	NOUN
cord-018764-02l423mk	237	12	precipitated	precipitate	VERB
cord-018764-02l423mk	237	13	cerebral	cerebral	ADJ
cord-018764-02l423mk	237	14	vaso	vaso	PROPN
cord-018764-02l423mk	237	15	-	-	PUNCT
cord-018764-02l423mk	237	16	occlusive	occlusive	ADJ
cord-018764-02l423mk	237	17	/	/	SYM
cord-018764-02l423mk	237	18	ischaemic	ischaemic	ADJ
cord-018764-02l423mk	237	19	(	(	PUNCT
cord-018764-02l423mk	237	20	i.e.	i.e.	X
cord-018764-02l423mk	237	21	stroke	stroke	NOUN
cord-018764-02l423mk	237	22	-	-	PUNCT
cord-018764-02l423mk	237	23	like	like	ADJ
cord-018764-02l423mk	237	24	)	)	PUNCT
cord-018764-02l423mk	237	25	events	event	NOUN
cord-018764-02l423mk	237	26	that	that	PRON
cord-018764-02l423mk	237	27	manifested	manifest	VERB
cord-018764-02l423mk	237	28	clinically	clinically	ADV
cord-018764-02l423mk	237	29	as	as	ADP
cord-018764-02l423mk	237	30	cm	cm	NOUN
cord-018764-02l423mk	237	31	.	.	PUNCT
cord-018764-02l423mk	238	1	however	however	ADV
cord-018764-02l423mk	238	2	,	,	PUNCT
cord-018764-02l423mk	238	3	cm	cm	PROPN
cord-018764-02l423mk	238	4	demonstrates	demonstrate	VERB
cord-018764-02l423mk	238	5	several	several	ADJ
cord-018764-02l423mk	238	6	features	feature	NOUN
cord-018764-02l423mk	238	7	that	that	PRON
cord-018764-02l423mk	238	8	are	be	AUX
cord-018764-02l423mk	238	9	atypical	atypical	ADJ
cord-018764-02l423mk	238	10	for	for	ADP
cord-018764-02l423mk	238	11	stroke	stroke	NOUN
cord-018764-02l423mk	238	12	.	.	PUNCT
cord-018764-02l423mk	239	1	in	in	ADP
cord-018764-02l423mk	239	2	children	child	NOUN
cord-018764-02l423mk	239	3	,	,	PUNCT
cord-018764-02l423mk	239	4	focal	focal	ADJ
cord-018764-02l423mk	239	5	neurological	neurological	ADJ
cord-018764-02l423mk	239	6	signs	sign	NOUN
cord-018764-02l423mk	239	7	do	do	AUX
cord-018764-02l423mk	239	8	not	not	PART
cord-018764-02l423mk	239	9	tend	tend	VERB
cord-018764-02l423mk	239	10	to	to	PART
cord-018764-02l423mk	239	11	accompany	accompany	VERB
cord-018764-02l423mk	239	12	coma	coma	NOUN
cord-018764-02l423mk	239	13	,	,	PUNCT
cord-018764-02l423mk	239	14	although	although	SCONJ
cord-018764-02l423mk	239	15	a	a	DET
cord-018764-02l423mk	239	16	sub	sub	NOUN
cord-018764-02l423mk	239	17	-	-	NOUN
cord-018764-02l423mk	239	18	set	set	ADJ
cord-018764-02l423mk	239	19	of	of	ADP
cord-018764-02l423mk	239	20	patients	patient	NOUN
cord-018764-02l423mk	239	21	do	do	AUX
cord-018764-02l423mk	239	22	exhibit	exhibit	VERB
cord-018764-02l423mk	239	23	hemiparesis	hemiparesis	NOUN
cord-018764-02l423mk	239	24	or	or	CCONJ
cord-018764-02l423mk	239	25	focal	focal	ADJ
cord-018764-02l423mk	239	26	brainstem	brainstem	NOUN
cord-018764-02l423mk	239	27	deficits	deficit	NOUN
cord-018764-02l423mk	239	28	during	during	ADP
cord-018764-02l423mk	239	29	the	the	DET
cord-018764-02l423mk	239	30	agonal	agonal	ADJ
cord-018764-02l423mk	239	31	period	period	NOUN
cord-018764-02l423mk	239	32	[	[	X
cord-018764-02l423mk	239	33	148	148	NUM
cord-018764-02l423mk	239	34	]	]	PUNCT
cord-018764-02l423mk	239	35	.	.	PUNCT
cord-018764-02l423mk	240	1	the	the	DET
cord-018764-02l423mk	240	2	incidence	incidence	NOUN
cord-018764-02l423mk	240	3	of	of	ADP
cord-018764-02l423mk	240	4	residual	residual	ADJ
cord-018764-02l423mk	240	5	neurological	neurological	ADJ
cord-018764-02l423mk	240	6	deficits	deficit	NOUN
cord-018764-02l423mk	240	7	following	follow	VERB
cord-018764-02l423mk	240	8	recovery	recovery	NOUN
cord-018764-02l423mk	240	9	from	from	ADP
cord-018764-02l423mk	240	10	coma	coma	NOUN
cord-018764-02l423mk	240	11	is	be	AUX
cord-018764-02l423mk	240	12	relatively	relatively	ADV
cord-018764-02l423mk	240	13	low	low	ADJ
cord-018764-02l423mk	240	14	(	(	PUNCT
cord-018764-02l423mk	240	15	11	11	NUM
cord-018764-02l423mk	240	16	%	%	NOUN
cord-018764-02l423mk	240	17	[	[	PUNCT
cord-018764-02l423mk	240	18	147	147	NUM
cord-018764-02l423mk	240	19	]	]	PUNCT
cord-018764-02l423mk	240	20	)	)	PUNCT
cord-018764-02l423mk	240	21	when	when	SCONJ
cord-018764-02l423mk	240	22	compared	compare	VERB
cord-018764-02l423mk	240	23	to	to	ADP
cord-018764-02l423mk	240	24	childhood	childhood	NOUN
cord-018764-02l423mk	240	25	stroke	stroke	NOUN
cord-018764-02l423mk	240	26	(	(	PUNCT
cord-018764-02l423mk	240	27	93	93	NUM
cord-018764-02l423mk	240	28	%	%	NOUN
cord-018764-02l423mk	240	29	had	have	VERB
cord-018764-02l423mk	240	30	residual	residual	ADJ
cord-018764-02l423mk	240	31	neurological	neurological	ADJ
cord-018764-02l423mk	240	32	deficit	deficit	NOUN
cord-018764-02l423mk	240	33	[	[	PUNCT
cord-018764-02l423mk	240	34	149	149	NUM
cord-018764-02l423mk	240	35	]	]	PUNCT
cord-018764-02l423mk	240	36	)	)	PUNCT
cord-018764-02l423mk	240	37	.	.	PUNCT
cord-018764-02l423mk	241	1	where	where	SCONJ
cord-018764-02l423mk	241	2	computer	computer	NOUN
cord-018764-02l423mk	241	3	tomography	tomography	NOUN
cord-018764-02l423mk	241	4	has	have	AUX
cord-018764-02l423mk	241	5	been	be	AUX
cord-018764-02l423mk	241	6	performed	perform	VERB
cord-018764-02l423mk	241	7	in	in	ADP
cord-018764-02l423mk	241	8	children	child	NOUN
cord-018764-02l423mk	241	9	,	,	PUNCT
cord-018764-02l423mk	241	10	diffuse	diffuse	VERB
cord-018764-02l423mk	241	11	brain	brain	NOUN
cord-018764-02l423mk	241	12	swelling	swelling	NOUN
cord-018764-02l423mk	241	13	was	be	AUX
cord-018764-02l423mk	241	14	observed	observe	VERB
cord-018764-02l423mk	241	15	[	[	X
cord-018764-02l423mk	241	16	150	150	NUM
cord-018764-02l423mk	241	17	]	]	PUNCT
cord-018764-02l423mk	241	18	rather	rather	ADV
cord-018764-02l423mk	241	19	than	than	ADP
cord-018764-02l423mk	241	20	focal	focal	ADJ
cord-018764-02l423mk	241	21	lesions	lesion	NOUN
cord-018764-02l423mk	241	22	more	more	ADV
cord-018764-02l423mk	241	23	typical	typical	ADJ
cord-018764-02l423mk	241	24	of	of	ADP
cord-018764-02l423mk	241	25	stroke	stroke	NOUN
cord-018764-02l423mk	241	26	.	.	PUNCT
cord-018764-02l423mk	242	1	although	although	SCONJ
cord-018764-02l423mk	242	2	retinal	retinal	ADJ
cord-018764-02l423mk	242	3	haemorrhages	haemorrhage	NOUN
cord-018764-02l423mk	242	4	have	have	AUX
cord-018764-02l423mk	242	5	been	be	AUX
cord-018764-02l423mk	242	6	observed	observe	VERB
cord-018764-02l423mk	242	7	in	in	ADP
cord-018764-02l423mk	242	8	46	46	NUM
cord-018764-02l423mk	242	9	%	%	NOUN
cord-018764-02l423mk	242	10	of	of	ADP
cord-018764-02l423mk	242	11	malawian	malawian	ADJ
cord-018764-02l423mk	242	12	children	child	NOUN
cord-018764-02l423mk	242	13	with	with	ADP
cord-018764-02l423mk	242	14	cm	cm	NOUN
cord-018764-02l423mk	242	15	(	(	PUNCT
cord-018764-02l423mk	242	16	and	and	CCONJ
cord-018764-02l423mk	242	17	in	in	ADP
cord-018764-02l423mk	242	18	63	63	NUM
cord-018764-02l423mk	242	19	%	%	NOUN
cord-018764-02l423mk	242	20	of	of	ADP
cord-018764-02l423mk	242	21	patients	patient	NOUN
cord-018764-02l423mk	242	22	who	who	PRON
cord-018764-02l423mk	242	23	died	die	VERB
cord-018764-02l423mk	242	24	)	)	PUNCT
cord-018764-02l423mk	242	25	,	,	PUNCT
cord-018764-02l423mk	242	26	these	these	DET
cord-018764-02l423mk	242	27	lesions	lesion	NOUN
cord-018764-02l423mk	242	28	were	be	AUX
cord-018764-02l423mk	242	29	also	also	ADV
cord-018764-02l423mk	242	30	seen	see	VERB
cord-018764-02l423mk	242	31	in	in	ADP
cord-018764-02l423mk	242	32	30	30	NUM
cord-018764-02l423mk	242	33	%	%	NOUN
cord-018764-02l423mk	242	34	of	of	ADP
cord-018764-02l423mk	242	35	children	child	NOUN
cord-018764-02l423mk	242	36	with	with	ADP
cord-018764-02l423mk	242	37	sma	sma	NOUN
cord-018764-02l423mk	242	38	in	in	ADP
cord-018764-02l423mk	242	39	the	the	DET
cord-018764-02l423mk	242	40	same	same	ADJ
cord-018764-02l423mk	242	41	study	study	NOUN
cord-018764-02l423mk	242	42	[	[	PUNCT
cord-018764-02l423mk	242	43	140	140	NUM
cord-018764-02l423mk	242	44	]	]	PUNCT
cord-018764-02l423mk	242	45	.	.	PUNCT
cord-018764-02l423mk	243	1	consequently	consequently	ADV
cord-018764-02l423mk	243	2	,	,	PUNCT
cord-018764-02l423mk	243	3	although	although	SCONJ
cord-018764-02l423mk	243	4	associated	associate	VERB
cord-018764-02l423mk	243	5	with	with	ADP
cord-018764-02l423mk	243	6	cm	cm	PROPN
cord-018764-02l423mk	243	7	,	,	PUNCT
cord-018764-02l423mk	243	8	retinal	retinal	ADJ
cord-018764-02l423mk	243	9	haemorrhages	haemorrhage	NOUN
cord-018764-02l423mk	243	10	do	do	AUX
cord-018764-02l423mk	243	11	not	not	PART
cord-018764-02l423mk	243	12	confirm	confirm	VERB
cord-018764-02l423mk	243	13	that	that	DET
cord-018764-02l423mk	243	14	focal	focal	ADJ
cord-018764-02l423mk	243	15	cerebral	cerebral	ADJ
cord-018764-02l423mk	243	16	vaso	vaso	PROPN
cord-018764-02l423mk	243	17	-	-	PUNCT
cord-018764-02l423mk	243	18	occlusive	occlusive	ADJ
cord-018764-02l423mk	243	19	/	/	SYM
cord-018764-02l423mk	243	20	ischaemic	ischaemic	ADJ
cord-018764-02l423mk	243	21	events	event	NOUN
cord-018764-02l423mk	243	22	underlie	underlie	ADJ
cord-018764-02l423mk	243	23	cm	cm	NOUN
cord-018764-02l423mk	243	24	.	.	PUNCT
cord-018764-02l423mk	244	1	similarly	similarly	ADV
cord-018764-02l423mk	244	2	,	,	PUNCT
cord-018764-02l423mk	244	3	histological	histological	ADJ
cord-018764-02l423mk	244	4	examination	examination	NOUN
cord-018764-02l423mk	244	5	of	of	ADP
cord-018764-02l423mk	244	6	32	32	NUM
cord-018764-02l423mk	244	7	fatal	fatal	ADJ
cord-018764-02l423mk	244	8	cm	cm	NOUN
cord-018764-02l423mk	244	9	cases	case	NOUN
cord-018764-02l423mk	244	10	of	of	ADP
cord-018764-02l423mk	244	11	african	african	ADJ
cord-018764-02l423mk	244	12	children	child	NOUN
cord-018764-02l423mk	244	13	at	at	ADP
cord-018764-02l423mk	244	14	autopsy	autopsy	PROPN
cord-018764-02l423mk	244	15	demonstrated	demonstrate	VERB
cord-018764-02l423mk	244	16	that	that	SCONJ
cord-018764-02l423mk	244	17	one	one	NUM
cord-018764-02l423mk	244	18	third	third	NOUN
cord-018764-02l423mk	244	19	had	have	VERB
cord-018764-02l423mk	244	20	little	little	ADJ
cord-018764-02l423mk	244	21	or	or	CCONJ
cord-018764-02l423mk	244	22	no	no	PRON
cord-018764-02l423mk	244	23	evidence	evidence	NOUN
cord-018764-02l423mk	244	24	of	of	ADP
cord-018764-02l423mk	244	25	local	local	ADJ
cord-018764-02l423mk	244	26	vascular	vascular	ADJ
cord-018764-02l423mk	244	27	change	change	NOUN
cord-018764-02l423mk	244	28	in	in	ADP
cord-018764-02l423mk	244	29	the	the	DET
cord-018764-02l423mk	244	30	brain	brain	NOUN
cord-018764-02l423mk	244	31	,	,	PUNCT
cord-018764-02l423mk	244	32	as	as	SCONJ
cord-018764-02l423mk	244	33	indicated	indicate	VERB
cord-018764-02l423mk	244	34	by	by	ADP
cord-018764-02l423mk	244	35	sequestered	sequester	VERB
cord-018764-02l423mk	244	36	parasites	parasite	NOUN
cord-018764-02l423mk	244	37	,	,	PUNCT
cord-018764-02l423mk	244	38	monocyte	monocyte	NOUN
cord-018764-02l423mk	244	39	clusters	cluster	NOUN
cord-018764-02l423mk	244	40	,	,	PUNCT
cord-018764-02l423mk	244	41	micro	micro	NOUN
cord-018764-02l423mk	244	42	-	-	NOUN
cord-018764-02l423mk	244	43	haemorrhages	haemorrhage	NOUN
cord-018764-02l423mk	244	44	,	,	PUNCT
cord-018764-02l423mk	244	45	local	local	ADJ
cord-018764-02l423mk	244	46	vascular	vascular	ADJ
cord-018764-02l423mk	244	47	inos	ino	NOUN
cord-018764-02l423mk	244	48	[	[	X
cord-018764-02l423mk	244	49	151	151	NUM
cord-018764-02l423mk	244	50	]	]	PUNCT
cord-018764-02l423mk	244	51	or	or	CCONJ
cord-018764-02l423mk	244	52	haemoxygenase	haemoxygenase	PROPN
cord-018764-02l423mk	244	53	-1	-1	PUNCT
cord-018764-02l423mk	245	1	(	(	PUNCT
cord-018764-02l423mk	245	2	ho-1	ho-1	X
cord-018764-02l423mk	245	3	)	)	PUNCT
cord-018764-02l423mk	246	1	[	[	PUNCT
cord-018764-02l423mk	246	2	152	152	NUM
cord-018764-02l423mk	246	3	]	]	X
cord-018764-02l423mk	246	4	staining	staining	NOUN
cord-018764-02l423mk	246	5	.	.	PUNCT
cord-018764-02l423mk	247	1	accepting	accept	VERB
cord-018764-02l423mk	247	2	that	that	PRON
cord-018764-02l423mk	247	3	cm	cm	PROPN
cord-018764-02l423mk	247	4	may	may	AUX
cord-018764-02l423mk	247	5	occur	occur	VERB
cord-018764-02l423mk	247	6	without	without	ADP
cord-018764-02l423mk	247	7	ischaemia	ischaemia	NOUN
cord-018764-02l423mk	247	8	does	do	AUX
cord-018764-02l423mk	247	9	not	not	PART
cord-018764-02l423mk	247	10	exclude	exclude	VERB
cord-018764-02l423mk	247	11	temporary	temporary	ADJ
cord-018764-02l423mk	247	12	or	or	CCONJ
cord-018764-02l423mk	247	13	less	less	ADV
cord-018764-02l423mk	247	14	severe	severe	ADJ
cord-018764-02l423mk	247	15	reductions	reduction	NOUN
cord-018764-02l423mk	247	16	in	in	ADP
cord-018764-02l423mk	247	17	vessel	vessel	NOUN
cord-018764-02l423mk	247	18	flow	flow	NOUN
cord-018764-02l423mk	247	19	occurring	occur	VERB
cord-018764-02l423mk	247	20	during	during	ADP
cord-018764-02l423mk	247	21	acute	acute	ADJ
cord-018764-02l423mk	247	22	cm	cm	NOUN
cord-018764-02l423mk	247	23	(	(	PUNCT
cord-018764-02l423mk	247	24	associated	associate	VERB
cord-018764-02l423mk	247	25	or	or	CCONJ
cord-018764-02l423mk	247	26	independent	independent	ADJ
cord-018764-02l423mk	247	27	of	of	ADP
cord-018764-02l423mk	247	28	parasite	parasite	ADJ
cord-018764-02l423mk	247	29	sequestration	sequestration	NOUN
cord-018764-02l423mk	247	30	)	)	PUNCT
cord-018764-02l423mk	247	31	that	that	PRON
cord-018764-02l423mk	247	32	may	may	AUX
cord-018764-02l423mk	247	33	contribute	contribute	VERB
cord-018764-02l423mk	247	34	to	to	ADP
cord-018764-02l423mk	247	35	impaired	impaired	ADJ
cord-018764-02l423mk	247	36	substrate	substrate	NOUN
cord-018764-02l423mk	247	37	delivery	delivery	NOUN
cord-018764-02l423mk	247	38	and	and	CCONJ
cord-018764-02l423mk	247	39	lead	lead	VERB
cord-018764-02l423mk	247	40	to	to	ADP
cord-018764-02l423mk	247	41	energy	energy	NOUN
cord-018764-02l423mk	247	42	imbalance	imbalance	NOUN
cord-018764-02l423mk	247	43	.	.	PUNCT
cord-018764-02l423mk	248	1	as	as	SCONJ
cord-018764-02l423mk	248	2	previously	previously	ADV
cord-018764-02l423mk	248	3	discussed	discuss	VERB
cord-018764-02l423mk	248	4	,	,	PUNCT
cord-018764-02l423mk	248	5	energy	energy	NOUN
cord-018764-02l423mk	248	6	imbalance	imbalance	NOUN
cord-018764-02l423mk	248	7	may	may	AUX
cord-018764-02l423mk	248	8	also	also	ADV
cord-018764-02l423mk	248	9	be	be	AUX
cord-018764-02l423mk	248	10	impaired	impair	VERB
cord-018764-02l423mk	248	11	due	due	ADP
cord-018764-02l423mk	248	12	to	to	ADP
cord-018764-02l423mk	248	13	the	the	DET
cord-018764-02l423mk	248	14	uncoupling	uncoupling	ADJ
cord-018764-02l423mk	248	15	action	action	NOUN
cord-018764-02l423mk	248	16	of	of	ADP
cord-018764-02l423mk	248	17	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	248	18	cytokines	cytokine	NOUN
cord-018764-02l423mk	248	19	on	on	ADP
cord-018764-02l423mk	248	20	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	248	21	atp	atp	NOUN
cord-018764-02l423mk	248	22	production	production	NOUN
cord-018764-02l423mk	248	23	.	.	PUNCT
cord-018764-02l423mk	249	1	in	in	ADP
cord-018764-02l423mk	249	2	gambian	gambian	ADJ
cord-018764-02l423mk	249	3	and	and	CCONJ
cord-018764-02l423mk	249	4	ghanaian	ghanaian	ADJ
cord-018764-02l423mk	249	5	children	child	NOUN
cord-018764-02l423mk	249	6	,	,	PUNCT
cord-018764-02l423mk	249	7	concentrations	concentration	NOUN
cord-018764-02l423mk	249	8	of	of	ADP
cord-018764-02l423mk	249	9	tnf	tnf	PROPN
cord-018764-02l423mk	249	10	and	and	CCONJ
cord-018764-02l423mk	249	11	its	its	PRON
cord-018764-02l423mk	249	12	receptor	receptor	NOUN
cord-018764-02l423mk	249	13	were	be	AUX
cord-018764-02l423mk	249	14	higher	high	ADJ
cord-018764-02l423mk	249	15	in	in	ADP
cord-018764-02l423mk	249	16	those	those	PRON
cord-018764-02l423mk	249	17	with	with	ADP
cord-018764-02l423mk	249	18	cm	cm	NOUN
cord-018764-02l423mk	249	19	than	than	ADP
cord-018764-02l423mk	249	20	in	in	ADP
cord-018764-02l423mk	249	21	those	those	PRON
cord-018764-02l423mk	249	22	with	with	ADP
cord-018764-02l423mk	249	23	mild	mild	ADJ
cord-018764-02l423mk	249	24	or	or	CCONJ
cord-018764-02l423mk	249	25	uncomplicated	uncomplicated	ADJ
cord-018764-02l423mk	249	26	malaria	malaria	NOUN
cord-018764-02l423mk	249	27	[	[	PUNCT
cord-018764-02l423mk	249	28	153	153	NUM
cord-018764-02l423mk	249	29	,	,	PUNCT
cord-018764-02l423mk	249	30	154	154	NUM
cord-018764-02l423mk	249	31	]	]	PUNCT
cord-018764-02l423mk	249	32	.	.	PUNCT
cord-018764-02l423mk	250	1	polymorphisms	polymorphism	NOUN
cord-018764-02l423mk	250	2	in	in	ADP
cord-018764-02l423mk	250	3	the	the	DET
cord-018764-02l423mk	250	4	tnf	tnf	PROPN
cord-018764-02l423mk	250	5	promoter	promoter	NOUN
cord-018764-02l423mk	250	6	region	region	NOUN
cord-018764-02l423mk	250	7	have	have	AUX
cord-018764-02l423mk	250	8	also	also	ADV
cord-018764-02l423mk	250	9	been	be	AUX
cord-018764-02l423mk	250	10	associated	associate	VERB
cord-018764-02l423mk	250	11	with	with	ADP
cord-018764-02l423mk	250	12	increased	increase	VERB
cord-018764-02l423mk	250	13	risk	risk	NOUN
cord-018764-02l423mk	250	14	of	of	ADP
cord-018764-02l423mk	250	15	cm	cm	NOUN
cord-018764-02l423mk	250	16	and	and	CCONJ
cord-018764-02l423mk	250	17	death	death	NOUN
cord-018764-02l423mk	250	18	[	[	PUNCT
cord-018764-02l423mk	250	19	155	155	NUM
cord-018764-02l423mk	250	20	]	]	PUNCT
cord-018764-02l423mk	250	21	or	or	CCONJ
cord-018764-02l423mk	250	22	neurological	neurological	ADJ
cord-018764-02l423mk	250	23	sequelae	sequelae	PROPN
cord-018764-02l423mk	251	1	[	[	X
cord-018764-02l423mk	251	2	156	156	NUM
cord-018764-02l423mk	251	3	]	]	PUNCT
cord-018764-02l423mk	251	4	.	.	PUNCT
cord-018764-02l423mk	252	1	cytokines	cytokine	NOUN
cord-018764-02l423mk	252	2	may	may	AUX
cord-018764-02l423mk	252	3	also	also	ADV
cord-018764-02l423mk	252	4	up	up	VERB
cord-018764-02l423mk	252	5	-	-	PUNCT
cord-018764-02l423mk	252	6	regulate	regulate	VERB
cord-018764-02l423mk	252	7	inos	ino	NOUN
cord-018764-02l423mk	252	8	in	in	ADP
cord-018764-02l423mk	252	9	brain	brain	NOUN
cord-018764-02l423mk	252	10	endothelial	endothelial	NOUN
cord-018764-02l423mk	252	11	cells	cell	NOUN
cord-018764-02l423mk	252	12	,	,	PUNCT
cord-018764-02l423mk	252	13	increasing	increase	VERB
cord-018764-02l423mk	252	14	production	production	NOUN
cord-018764-02l423mk	252	15	of	of	ADP
cord-018764-02l423mk	252	16	no	no	PRON
cord-018764-02l423mk	252	17	,	,	PUNCT
cord-018764-02l423mk	252	18	which	which	PRON
cord-018764-02l423mk	252	19	could	could	AUX
cord-018764-02l423mk	252	20	then	then	ADV
cord-018764-02l423mk	252	21	diffuse	diffuse	VERB
cord-018764-02l423mk	252	22	into	into	ADP
cord-018764-02l423mk	252	23	brain	brain	NOUN
cord-018764-02l423mk	252	24	tissue	tissue	NOUN
cord-018764-02l423mk	252	25	and	and	CCONJ
cord-018764-02l423mk	252	26	disrupt	disrupt	VERB
cord-018764-02l423mk	252	27	neuronal	neuronal	ADJ
cord-018764-02l423mk	252	28	(	(	PUNCT
cord-018764-02l423mk	252	29	and/or	and/or	CCONJ
cord-018764-02l423mk	252	30	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	252	31	)	)	PUNCT
cord-018764-02l423mk	252	32	function	function	NOUN
cord-018764-02l423mk	252	33	[	[	PUNCT
cord-018764-02l423mk	252	34	157	157	NUM
cord-018764-02l423mk	252	35	,	,	PUNCT
cord-018764-02l423mk	252	36	158	158	NUM
cord-018764-02l423mk	252	37	]	]	PUNCT
cord-018764-02l423mk	252	38	.	.	PUNCT
cord-018764-02l423mk	253	1	in	in	ADP
cord-018764-02l423mk	253	2	the	the	DET
cord-018764-02l423mk	253	3	brain	brain	NOUN
cord-018764-02l423mk	253	4	,	,	PUNCT
cord-018764-02l423mk	253	5	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	253	6	function	function	NOUN
cord-018764-02l423mk	253	7	may	may	AUX
cord-018764-02l423mk	253	8	also	also	ADV
cord-018764-02l423mk	253	9	be	be	AUX
cord-018764-02l423mk	253	10	influenced	influence	VERB
cord-018764-02l423mk	253	11	by	by	ADP
cord-018764-02l423mk	253	12	neuronal	neuronal	ADJ
cord-018764-02l423mk	253	13	excitotoxins	excitotoxin	NOUN
cord-018764-02l423mk	253	14	.	.	PUNCT
cord-018764-02l423mk	254	1	within	within	ADP
cord-018764-02l423mk	254	2	the	the	DET
cord-018764-02l423mk	254	3	simplified	simplified	ADJ
cord-018764-02l423mk	254	4	model	model	NOUN
cord-018764-02l423mk	254	5	of	of	ADP
cord-018764-02l423mk	254	6	dissociated	dissociate	VERB
cord-018764-02l423mk	254	7	neuronal	neuronal	ADJ
cord-018764-02l423mk	254	8	culture	culture	NOUN
cord-018764-02l423mk	254	9	,	,	PUNCT
cord-018764-02l423mk	254	10	mitochondria	mitochondria	NOUN
cord-018764-02l423mk	254	11	appear	appear	VERB
cord-018764-02l423mk	254	12	to	to	PART
cord-018764-02l423mk	254	13	play	play	VERB
cord-018764-02l423mk	254	14	a	a	DET
cord-018764-02l423mk	254	15	critical	critical	ADJ
cord-018764-02l423mk	254	16	role	role	NOUN
cord-018764-02l423mk	254	17	in	in	ADP
cord-018764-02l423mk	254	18	neuronal	neuronal	ADJ
cord-018764-02l423mk	254	19	homeostasis	homeostasis	NOUN
cord-018764-02l423mk	254	20	during	during	ADP
cord-018764-02l423mk	254	21	excitotoxin	excitotoxin	PROPN
cord-018764-02l423mk	254	22	exposure	exposure	PROPN
cord-018764-02l423mk	254	23	.	.	PUNCT
cord-018764-02l423mk	255	1	mitochondria	mitochondria	PROPN
cord-018764-02l423mk	255	2	are	be	AUX
cord-018764-02l423mk	255	3	not	not	PART
cord-018764-02l423mk	255	4	only	only	ADV
cord-018764-02l423mk	255	5	involved	involve	VERB
cord-018764-02l423mk	255	6	with	with	ADP
cord-018764-02l423mk	255	7	maintaining	maintain	VERB
cord-018764-02l423mk	255	8	atp	atp	NOUN
cord-018764-02l423mk	255	9	production	production	NOUN
cord-018764-02l423mk	255	10	but	but	CCONJ
cord-018764-02l423mk	255	11	also	also	ADV
cord-018764-02l423mk	255	12	calcium	calcium	NOUN
cord-018764-02l423mk	255	13	homeostasis	homeostasis	NOUN
cord-018764-02l423mk	255	14	,	,	PUNCT
cord-018764-02l423mk	255	15	and	and	CCONJ
cord-018764-02l423mk	255	16	generation	generation	NOUN
cord-018764-02l423mk	255	17	and	and	CCONJ
cord-018764-02l423mk	255	18	detoxification	detoxification	NOUN
cord-018764-02l423mk	255	19	of	of	ADP
cord-018764-02l423mk	255	20	reactive	reactive	ADJ
cord-018764-02l423mk	255	21	oxygen	oxygen	NOUN
cord-018764-02l423mk	255	22	species	specie	NOUN
cord-018764-02l423mk	255	23	[	[	PUNCT
cord-018764-02l423mk	255	24	107	107	NUM
cord-018764-02l423mk	255	25	]	]	PUNCT
cord-018764-02l423mk	255	26	.	.	PUNCT
cord-018764-02l423mk	256	1	excitotoxin	excitotoxin	PROPN
cord-018764-02l423mk	256	2	production	production	NOUN
cord-018764-02l423mk	256	3	may	may	AUX
cord-018764-02l423mk	256	4	also	also	ADV
cord-018764-02l423mk	256	5	be	be	AUX
cord-018764-02l423mk	256	6	influenced	influence	VERB
cord-018764-02l423mk	256	7	by	by	ADP
cord-018764-02l423mk	256	8	cytokine	cytokine	NOUN
cord-018764-02l423mk	256	9	release	release	NOUN
cord-018764-02l423mk	256	10	.	.	PUNCT
cord-018764-02l423mk	257	1	tnf	tnf	PROPN
cord-018764-02l423mk	257	2	administration	administration	PROPN
cord-018764-02l423mk	257	3	has	have	AUX
cord-018764-02l423mk	257	4	been	be	AUX
cord-018764-02l423mk	257	5	shown	show	VERB
cord-018764-02l423mk	257	6	to	to	PART
cord-018764-02l423mk	257	7	alter	alter	VERB
cord-018764-02l423mk	257	8	brain	brain	NOUN
cord-018764-02l423mk	257	9	metabolism	metabolism	NOUN
cord-018764-02l423mk	257	10	of	of	ADP
cord-018764-02l423mk	257	11	tryptophan	tryptophan	NOUN
cord-018764-02l423mk	257	12	to	to	PART
cord-018764-02l423mk	257	13	produce	produce	VERB
cord-018764-02l423mk	257	14	more	more	ADJ
cord-018764-02l423mk	257	15	kynurinine	kynurinine	NOUN
cord-018764-02l423mk	257	16	[	[	X
cord-018764-02l423mk	257	17	159	159	NUM
cord-018764-02l423mk	257	18	,	,	PUNCT
cord-018764-02l423mk	257	19	160	160	NUM
cord-018764-02l423mk	257	20	]	]	PUNCT
cord-018764-02l423mk	257	21	.	.	PUNCT
cord-018764-02l423mk	258	1	thus	thus	ADV
cord-018764-02l423mk	258	2	,	,	PUNCT
cord-018764-02l423mk	258	3	as	as	ADP
cord-018764-02l423mk	258	4	part	part	NOUN
cord-018764-02l423mk	258	5	of	of	ADP
cord-018764-02l423mk	258	6	a	a	DET
cord-018764-02l423mk	258	7	general	general	ADJ
cord-018764-02l423mk	258	8	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	258	9	reaction	reaction	NOUN
cord-018764-02l423mk	258	10	,	,	PUNCT
cord-018764-02l423mk	258	11	increased	increase	VERB
cord-018764-02l423mk	258	12	excitotoxin	excitotoxin	PROPN
cord-018764-02l423mk	258	13	generation	generation	NOUN
cord-018764-02l423mk	258	14	during	during	ADP
cord-018764-02l423mk	258	15	acute	acute	ADJ
cord-018764-02l423mk	258	16	malaria	malaria	NOUN
cord-018764-02l423mk	258	17	may	may	AUX
cord-018764-02l423mk	258	18	contribute	contribute	VERB
cord-018764-02l423mk	258	19	to	to	ADP
cord-018764-02l423mk	258	20	cellular	cellular	ADJ
cord-018764-02l423mk	258	21	energy	energy	NOUN
cord-018764-02l423mk	258	22	imbalance	imbalance	NOUN
cord-018764-02l423mk	258	23	.	.	PUNCT
cord-018764-02l423mk	259	1	elevated	elevated	ADJ
cord-018764-02l423mk	259	2	levels	level	NOUN
cord-018764-02l423mk	259	3	of	of	ADP
cord-018764-02l423mk	259	4	neuronal	neuronal	ADJ
cord-018764-02l423mk	259	5	excitotoxins	excitotoxin	NOUN
cord-018764-02l423mk	259	6	(	(	PUNCT
cord-018764-02l423mk	259	7	quinolinic	quinolinic	NOUN
cord-018764-02l423mk	259	8	and	and	CCONJ
cord-018764-02l423mk	259	9	picolinic	picolinic	ADJ
cord-018764-02l423mk	259	10	acid	acid	NOUN
cord-018764-02l423mk	259	11	)	)	PUNCT
cord-018764-02l423mk	259	12	in	in	ADP
cord-018764-02l423mk	259	13	the	the	DET
cord-018764-02l423mk	259	14	csf	csf	NOUN
cord-018764-02l423mk	259	15	have	have	AUX
cord-018764-02l423mk	259	16	been	be	AUX
cord-018764-02l423mk	259	17	associated	associate	VERB
cord-018764-02l423mk	259	18	with	with	ADP
cord-018764-02l423mk	259	19	a	a	DET
cord-018764-02l423mk	259	20	fatal	fatal	ADJ
cord-018764-02l423mk	259	21	outcome	outcome	NOUN
cord-018764-02l423mk	259	22	in	in	ADP
cord-018764-02l423mk	259	23	malawian	malawian	ADJ
cord-018764-02l423mk	259	24	children	child	NOUN
cord-018764-02l423mk	259	25	with	with	ADP
cord-018764-02l423mk	259	26	cm	cm	NOUN
cord-018764-02l423mk	259	27	[	[	PUNCT
cord-018764-02l423mk	259	28	161	161	NUM
cord-018764-02l423mk	259	29	]	]	PUNCT
cord-018764-02l423mk	259	30	.	.	PUNCT
cord-018764-02l423mk	260	1	similarly	similarly	ADV
cord-018764-02l423mk	260	2	,	,	PUNCT
cord-018764-02l423mk	260	3	a	a	DET
cord-018764-02l423mk	260	4	graded	graded	ADJ
cord-018764-02l423mk	260	5	increment	increment	NOUN
cord-018764-02l423mk	260	6	of	of	ADP
cord-018764-02l423mk	260	7	quinolinic	quinolinic	ADJ
cord-018764-02l423mk	260	8	acid	acid	NOUN
cord-018764-02l423mk	260	9	concentration	concentration	NOUN
cord-018764-02l423mk	260	10	in	in	ADP
cord-018764-02l423mk	260	11	csf	csf	NOUN
cord-018764-02l423mk	260	12	was	be	AUX
cord-018764-02l423mk	260	13	observed	observe	VERB
cord-018764-02l423mk	260	14	across	across	ADP
cord-018764-02l423mk	260	15	patient	patient	ADJ
cord-018764-02l423mk	260	16	outcome	outcome	NOUN
cord-018764-02l423mk	260	17	groups	group	NOUN
cord-018764-02l423mk	260	18	of	of	ADP
cord-018764-02l423mk	260	19	increasing	increase	VERB
cord-018764-02l423mk	260	20	severity	severity	NOUN
cord-018764-02l423mk	260	21	in	in	ADP
cord-018764-02l423mk	260	22	african	african	ADJ
cord-018764-02l423mk	260	23	children	child	NOUN
cord-018764-02l423mk	260	24	[	[	PUNCT
cord-018764-02l423mk	260	25	162	162	NUM
cord-018764-02l423mk	260	26	]	]	PUNCT
cord-018764-02l423mk	260	27	.	.	PUNCT
cord-018764-02l423mk	261	1	although	although	SCONJ
cord-018764-02l423mk	261	2	a	a	DET
cord-018764-02l423mk	261	3	subset	subset	NOUN
cord-018764-02l423mk	261	4	of	of	ADP
cord-018764-02l423mk	261	5	the	the	DET
cord-018764-02l423mk	261	6	malawaian	malawaian	ADJ
cord-018764-02l423mk	261	7	autopsy	autopsy	ADJ
cord-018764-02l423mk	261	8	patients	patient	NOUN
cord-018764-02l423mk	261	9	[	[	PUNCT
cord-018764-02l423mk	261	10	163	163	NUM
cord-018764-02l423mk	261	11	]	]	PUNCT
cord-018764-02l423mk	261	12	demonstrated	demonstrate	VERB
cord-018764-02l423mk	261	13	negligible	negligible	ADJ
cord-018764-02l423mk	261	14	histological	histological	ADJ
cord-018764-02l423mk	261	15	change	change	NOUN
cord-018764-02l423mk	261	16	in	in	ADP
cord-018764-02l423mk	261	17	their	their	PRON
cord-018764-02l423mk	261	18	brains	brain	NOUN
cord-018764-02l423mk	261	19	,	,	PUNCT
cord-018764-02l423mk	261	20	they	they	PRON
cord-018764-02l423mk	261	21	did	do	AUX
cord-018764-02l423mk	261	22	demonstrate	demonstrate	VERB
cord-018764-02l423mk	261	23	inflammation	inflammation	NOUN
cord-018764-02l423mk	261	24	,	,	PUNCT
cord-018764-02l423mk	261	25	as	as	SCONJ
cord-018764-02l423mk	261	26	indicated	indicate	VERB
cord-018764-02l423mk	261	27	by	by	ADP
cord-018764-02l423mk	261	28	inos	ino	NOUN
cord-018764-02l423mk	261	29	,	,	PUNCT
cord-018764-02l423mk	261	30	mif	mif	PROPN
cord-018764-02l423mk	261	31	[	[	PUNCT
cord-018764-02l423mk	261	32	151	151	NUM
cord-018764-02l423mk	261	33	]	]	PUNCT
cord-018764-02l423mk	261	34	and	and	CCONJ
cord-018764-02l423mk	261	35	ho-1	ho-1	NOUN
cord-018764-02l423mk	262	1	[	[	X
cord-018764-02l423mk	262	2	152	152	NUM
cord-018764-02l423mk	262	3	]	]	PUNCT
cord-018764-02l423mk	262	4	,	,	PUNCT
cord-018764-02l423mk	262	5	staining	stain	VERB
cord-018764-02l423mk	262	6	in	in	ADP
cord-018764-02l423mk	262	7	other	other	ADJ
cord-018764-02l423mk	262	8	tissues	tissue	NOUN
cord-018764-02l423mk	262	9	.	.	PUNCT
cord-018764-02l423mk	263	1	these	these	DET
cord-018764-02l423mk	263	2	systemic	systemic	ADJ
cord-018764-02l423mk	263	3	changes	change	NOUN
cord-018764-02l423mk	263	4	were	be	AUX
cord-018764-02l423mk	263	5	shared	share	VERB
cord-018764-02l423mk	263	6	with	with	ADP
cord-018764-02l423mk	263	7	the	the	DET
cord-018764-02l423mk	263	8	comatose	comatose	ADJ
cord-018764-02l423mk	263	9	sepsis	sepsis	NOUN
cord-018764-02l423mk	263	10	cases	case	NOUN
cord-018764-02l423mk	263	11	in	in	ADP
cord-018764-02l423mk	263	12	the	the	DET
cord-018764-02l423mk	263	13	study	study	NOUN
cord-018764-02l423mk	263	14	,	,	PUNCT
cord-018764-02l423mk	263	15	and	and	CCONJ
cord-018764-02l423mk	263	16	therefore	therefore	ADV
cord-018764-02l423mk	263	17	are	be	AUX
cord-018764-02l423mk	263	18	consistent	consistent	ADJ
cord-018764-02l423mk	263	19	with	with	ADP
cord-018764-02l423mk	263	20	the	the	DET
cord-018764-02l423mk	263	21	premise	premise	NOUN
cord-018764-02l423mk	263	22	that	that	SCONJ
cord-018764-02l423mk	263	23	coma	coma	NOUN
cord-018764-02l423mk	263	24	may	may	AUX
cord-018764-02l423mk	263	25	in	in	ADP
cord-018764-02l423mk	263	26	part	part	NOUN
cord-018764-02l423mk	263	27	be	be	AUX
cord-018764-02l423mk	263	28	secondary	secondary	ADJ
cord-018764-02l423mk	263	29	to	to	ADP
cord-018764-02l423mk	263	30	a	a	DET
cord-018764-02l423mk	263	31	host	host	NOUN
cord-018764-02l423mk	263	32	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	263	33	response	response	NOUN
cord-018764-02l423mk	263	34	to	to	ADP
cord-018764-02l423mk	263	35	systemic	systemic	ADJ
cord-018764-02l423mk	263	36	infection	infection	NOUN
cord-018764-02l423mk	263	37	.	.	PUNCT
cord-018764-02l423mk	264	1	below	below	ADV
cord-018764-02l423mk	264	2	are	be	AUX
cord-018764-02l423mk	264	3	further	further	ADJ
cord-018764-02l423mk	264	4	examples	example	NOUN
cord-018764-02l423mk	264	5	of	of	ADP
cord-018764-02l423mk	264	6	systemic	systemic	ADJ
cord-018764-02l423mk	264	7	responses	response	NOUN
cord-018764-02l423mk	264	8	to	to	ADP
cord-018764-02l423mk	264	9	infection	infection	NOUN
cord-018764-02l423mk	264	10	that	that	PRON
cord-018764-02l423mk	264	11	present	present	ADJ
cord-018764-02l423mk	264	12	with	with	ADP
cord-018764-02l423mk	264	13	diffuse	diffuse	NOUN
cord-018764-02l423mk	264	14	cerebral	cerebral	ADJ
cord-018764-02l423mk	264	15	syndromes	syndrome	NOUN
cord-018764-02l423mk	264	16	,	,	PUNCT
cord-018764-02l423mk	264	17	including	include	VERB
cord-018764-02l423mk	264	18	coma	coma	NOUN
cord-018764-02l423mk	264	19	.	.	PUNCT
cord-018764-02l423mk	265	1	in	in	ADP
cord-018764-02l423mk	265	2	the	the	DET
cord-018764-02l423mk	265	3	past	past	NOUN
cord-018764-02l423mk	265	4	,	,	PUNCT
cord-018764-02l423mk	265	5	the	the	DET
cord-018764-02l423mk	265	6	term	term	NOUN
cord-018764-02l423mk	265	7	cm	cm	PROPN
cord-018764-02l423mk	265	8	has	have	AUX
cord-018764-02l423mk	265	9	been	be	AUX
cord-018764-02l423mk	265	10	restricted	restrict	VERB
cord-018764-02l423mk	265	11	to	to	ADP
cord-018764-02l423mk	265	12	falciparum	falciparum	NOUN
cord-018764-02l423mk	265	13	malaria	malaria	NOUN
cord-018764-02l423mk	265	14	,	,	PUNCT
cord-018764-02l423mk	265	15	and	and	CCONJ
cord-018764-02l423mk	265	16	patients	patient	NOUN
cord-018764-02l423mk	265	17	with	with	ADP
cord-018764-02l423mk	265	18	p.	p.	PROPN
cord-018764-02l423mk	265	19	vivax	vivax	PROPN
cord-018764-02l423mk	265	20	infection	infection	NOUN
cord-018764-02l423mk	265	21	exhibiting	exhibit	VERB
cord-018764-02l423mk	265	22	symptoms	symptom	NOUN
cord-018764-02l423mk	265	23	of	of	ADP
cord-018764-02l423mk	265	24	severe	severe	ADJ
cord-018764-02l423mk	265	25	malaria	malaria	NOUN
cord-018764-02l423mk	265	26	,	,	PUNCT
cord-018764-02l423mk	265	27	including	include	VERB
cord-018764-02l423mk	265	28	coma	coma	NOUN
cord-018764-02l423mk	265	29	,	,	PUNCT
cord-018764-02l423mk	265	30	have	have	AUX
cord-018764-02l423mk	265	31	been	be	AUX
cord-018764-02l423mk	265	32	dismissed	dismiss	VERB
cord-018764-02l423mk	265	33	as	as	ADP
cord-018764-02l423mk	265	34	undiagnosed	undiagnosed	ADJ
cord-018764-02l423mk	265	35	falciparum	falciparum	NOUN
cord-018764-02l423mk	265	36	co	co	NOUN
cord-018764-02l423mk	265	37	-	-	NOUN
cord-018764-02l423mk	265	38	infections	infection	NOUN
cord-018764-02l423mk	265	39	.	.	PUNCT
cord-018764-02l423mk	266	1	however	however	ADV
cord-018764-02l423mk	266	2	,	,	PUNCT
cord-018764-02l423mk	266	3	the	the	DET
cord-018764-02l423mk	266	4	use	use	NOUN
cord-018764-02l423mk	266	5	of	of	ADP
cord-018764-02l423mk	266	6	more	more	ADV
cord-018764-02l423mk	266	7	sensitive	sensitive	ADJ
cord-018764-02l423mk	266	8	diagnostic	diagnostic	ADJ
cord-018764-02l423mk	266	9	techniques	technique	NOUN
cord-018764-02l423mk	266	10	makes	make	VERB
cord-018764-02l423mk	266	11	such	such	ADJ
cord-018764-02l423mk	266	12	dismissal	dismissal	NOUN
cord-018764-02l423mk	266	13	less	less	ADV
cord-018764-02l423mk	266	14	tenable	tenable	ADJ
cord-018764-02l423mk	266	15	.	.	PUNCT
cord-018764-02l423mk	267	1	two	two	NUM
cord-018764-02l423mk	267	2	such	such	ADJ
cord-018764-02l423mk	267	3	studies	study	NOUN
cord-018764-02l423mk	267	4	report	report	VERB
cord-018764-02l423mk	267	5	adults	adult	NOUN
cord-018764-02l423mk	267	6	exhibiting	exhibit	VERB
cord-018764-02l423mk	267	7	severe	severe	ADJ
cord-018764-02l423mk	267	8	malaria	malaria	NOUN
cord-018764-02l423mk	267	9	with	with	ADP
cord-018764-02l423mk	267	10	p.	p.	PROPN
cord-018764-02l423mk	267	11	vivax	vivax	PROPN
cord-018764-02l423mk	268	1	(	(	PUNCT
cord-018764-02l423mk	268	2	but	but	CCONJ
cord-018764-02l423mk	268	3	not	not	PART
cord-018764-02l423mk	268	4	p.	p.	PROPN
cord-018764-02l423mk	268	5	falciparum	falciparum	NOUN
cord-018764-02l423mk	268	6	)	)	PUNCT
cord-018764-02l423mk	268	7	infection	infection	NOUN
cord-018764-02l423mk	268	8	detectable	detectable	ADJ
cord-018764-02l423mk	268	9	on	on	ADP
cord-018764-02l423mk	268	10	pcr	pcr	NOUN
cord-018764-02l423mk	268	11	and	and	CCONJ
cord-018764-02l423mk	268	12	serological	serological	ADJ
cord-018764-02l423mk	268	13	and	and	CCONJ
cord-018764-02l423mk	268	14	testing	testing	NOUN
cord-018764-02l423mk	268	15	[	[	PUNCT
cord-018764-02l423mk	268	16	142	142	NUM
cord-018764-02l423mk	268	17	,	,	PUNCT
cord-018764-02l423mk	268	18	143	143	NUM
cord-018764-02l423mk	268	19	]	]	PUNCT
cord-018764-02l423mk	268	20	.	.	PUNCT
cord-018764-02l423mk	269	1	the	the	DET
cord-018764-02l423mk	269	2	patients	patient	NOUN
cord-018764-02l423mk	269	3	exhibited	exhibit	VERB
cord-018764-02l423mk	269	4	multiple	multiple	ADJ
cord-018764-02l423mk	269	5	organ	organ	NOUN
cord-018764-02l423mk	269	6	failure	failure	NOUN
cord-018764-02l423mk	269	7	including	include	VERB
cord-018764-02l423mk	269	8	cerebral	cerebral	ADJ
cord-018764-02l423mk	269	9	symptoms	symptom	NOUN
cord-018764-02l423mk	269	10	,	,	PUNCT
cord-018764-02l423mk	269	11	renal	renal	ADJ
cord-018764-02l423mk	269	12	failure	failure	NOUN
cord-018764-02l423mk	269	13	,	,	PUNCT
cord-018764-02l423mk	269	14	circulatory	circulatory	ADJ
cord-018764-02l423mk	269	15	collapse	collapse	NOUN
cord-018764-02l423mk	269	16	,	,	PUNCT
cord-018764-02l423mk	269	17	severe	severe	ADJ
cord-018764-02l423mk	269	18	anaemia	anaemia	NOUN
cord-018764-02l423mk	269	19	,	,	PUNCT
cord-018764-02l423mk	269	20	haemoglobinuria	haemoglobinuria	PROPN
cord-018764-02l423mk	269	21	,	,	PUNCT
cord-018764-02l423mk	269	22	abnormal	abnormal	ADJ
cord-018764-02l423mk	269	23	bleeding	bleeding	NOUN
cord-018764-02l423mk	269	24	,	,	PUNCT
cord-018764-02l423mk	269	25	acute	acute	ADJ
cord-018764-02l423mk	269	26	respiratory	respiratory	ADJ
cord-018764-02l423mk	269	27	distress	distress	NOUN
cord-018764-02l423mk	269	28	syndrome	syndrome	NOUN
cord-018764-02l423mk	269	29	,	,	PUNCT
cord-018764-02l423mk	269	30	and	and	CCONJ
cord-018764-02l423mk	269	31	jaundice	jaundice	NOUN
cord-018764-02l423mk	269	32	.	.	PUNCT
cord-018764-02l423mk	270	1	vivax	vivax	PROPN
cord-018764-02l423mk	270	2	malaria	malaria	PROPN
cord-018764-02l423mk	270	3	has	have	AUX
cord-018764-02l423mk	270	4	been	be	AUX
cord-018764-02l423mk	270	5	associated	associate	VERB
cord-018764-02l423mk	270	6	with	with	ADP
cord-018764-02l423mk	270	7	a	a	DET
cord-018764-02l423mk	270	8	strong	strong	ADJ
cord-018764-02l423mk	270	9	systemic	systemic	ADJ
cord-018764-02l423mk	270	10	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	270	11	response	response	NOUN
cord-018764-02l423mk	270	12	[	[	X
cord-018764-02l423mk	270	13	164	164	NUM
cord-018764-02l423mk	270	14	]	]	PUNCT
cord-018764-02l423mk	270	15	,	,	PUNCT
cord-018764-02l423mk	270	16	but	but	CCONJ
cord-018764-02l423mk	270	17	this	this	PRON
cord-018764-02l423mk	270	18	was	be	AUX
cord-018764-02l423mk	270	19	not	not	PART
cord-018764-02l423mk	270	20	investigated	investigate	VERB
cord-018764-02l423mk	270	21	in	in	ADP
cord-018764-02l423mk	270	22	the	the	DET
cord-018764-02l423mk	270	23	above	above	ADJ
cord-018764-02l423mk	270	24	studies	study	NOUN
cord-018764-02l423mk	270	25	.	.	PUNCT
cord-018764-02l423mk	271	1	sepsis	sepsis	NOUN
cord-018764-02l423mk	271	2	-	-	PUNCT
cord-018764-02l423mk	271	3	associated	associate	VERB
cord-018764-02l423mk	271	4	encephalopathy	encephalopathy	ADJ
cord-018764-02l423mk	271	5	(	(	PUNCT
cord-018764-02l423mk	271	6	sae	sae	PROPN
cord-018764-02l423mk	271	7	)	)	PUNCT
cord-018764-02l423mk	271	8	syndrome	syndrome	NOUN
cord-018764-02l423mk	271	9	has	have	VERB
cord-018764-02l423mk	271	10	multiple	multiple	ADJ
cord-018764-02l423mk	271	11	features	feature	NOUN
cord-018764-02l423mk	271	12	that	that	PRON
cord-018764-02l423mk	271	13	resemble	resemble	VERB
cord-018764-02l423mk	271	14	cm	cm	NOUN
cord-018764-02l423mk	271	15	.	.	PUNCT
cord-018764-02l423mk	272	1	it	it	PRON
cord-018764-02l423mk	272	2	is	be	AUX
cord-018764-02l423mk	272	3	characterised	characterise	VERB
cord-018764-02l423mk	272	4	by	by	ADP
cord-018764-02l423mk	272	5	a	a	DET
cord-018764-02l423mk	272	6	diffuse	diffuse	NOUN
cord-018764-02l423mk	272	7	disturbance	disturbance	NOUN
cord-018764-02l423mk	272	8	of	of	ADP
cord-018764-02l423mk	272	9	cerebral	cerebral	ADJ
cord-018764-02l423mk	272	10	function	function	NOUN
cord-018764-02l423mk	272	11	(	(	PUNCT
cord-018764-02l423mk	272	12	typically	typically	ADV
cord-018764-02l423mk	272	13	impairment	impairment	NOUN
cord-018764-02l423mk	272	14	of	of	ADP
cord-018764-02l423mk	272	15	consciousness	consciousness	NOUN
cord-018764-02l423mk	272	16	)	)	PUNCT
cord-018764-02l423mk	272	17	that	that	PRON
cord-018764-02l423mk	272	18	occurs	occur	VERB
cord-018764-02l423mk	272	19	in	in	ADP
cord-018764-02l423mk	272	20	the	the	DET
cord-018764-02l423mk	272	21	context	context	NOUN
cord-018764-02l423mk	272	22	of	of	ADP
cord-018764-02l423mk	272	23	systemic	systemic	ADJ
cord-018764-02l423mk	272	24	response	response	NOUN
cord-018764-02l423mk	272	25	to	to	ADP
cord-018764-02l423mk	272	26	infection	infection	NOUN
cord-018764-02l423mk	272	27	without	without	ADP
cord-018764-02l423mk	272	28	direct	direct	ADJ
cord-018764-02l423mk	272	29	neuroinvasion	neuroinvasion	NOUN
cord-018764-02l423mk	272	30	(	(	PUNCT
cord-018764-02l423mk	272	31	i.e.	i.e.	X
cord-018764-02l423mk	272	32	meningitis	meningitis	PROPN
cord-018764-02l423mk	272	33	,	,	PUNCT
cord-018764-02l423mk	272	34	macroscopic	macroscopic	ADJ
cord-018764-02l423mk	272	35	cerebritis	cerebritis	NOUN
cord-018764-02l423mk	272	36	and	and	CCONJ
cord-018764-02l423mk	272	37	brain	brain	NOUN
cord-018764-02l423mk	272	38	abscesses	abscess	NOUN
cord-018764-02l423mk	272	39	are	be	AUX
cord-018764-02l423mk	272	40	excluded	exclude	VERB
cord-018764-02l423mk	272	41	)	)	PUNCT
cord-018764-02l423mk	272	42	.	.	PUNCT
cord-018764-02l423mk	273	1	sae	sae	PROPN
cord-018764-02l423mk	273	2	is	be	AUX
cord-018764-02l423mk	273	3	associated	associate	VERB
cord-018764-02l423mk	273	4	with	with	ADP
cord-018764-02l423mk	273	5	generalised	generalised	ADJ
cord-018764-02l423mk	273	6	slow	slow	ADJ
cord-018764-02l423mk	273	7	waves	wave	NOUN
cord-018764-02l423mk	273	8	on	on	ADP
cord-018764-02l423mk	273	9	the	the	DET
cord-018764-02l423mk	273	10	electroencephalogram	electroencephalogram	NOUN
cord-018764-02l423mk	273	11	(	(	PUNCT
cord-018764-02l423mk	273	12	eeg	eeg	NOUN
cord-018764-02l423mk	273	13	)	)	PUNCT
cord-018764-02l423mk	273	14	,	,	PUNCT
cord-018764-02l423mk	273	15	with	with	ADP
cord-018764-02l423mk	273	16	the	the	DET
cord-018764-02l423mk	273	17	depth	depth	NOUN
cord-018764-02l423mk	273	18	of	of	ADP
cord-018764-02l423mk	273	19	coma	coma	NOUN
cord-018764-02l423mk	273	20	linked	link	VERB
cord-018764-02l423mk	273	21	with	with	ADP
cord-018764-02l423mk	273	22	mortality	mortality	NOUN
cord-018764-02l423mk	273	23	.	.	PUNCT
cord-018764-02l423mk	274	1	mild	mild	ADJ
cord-018764-02l423mk	274	2	sae	sae	PROPN
cord-018764-02l423mk	274	3	cases	case	NOUN
cord-018764-02l423mk	274	4	often	often	ADV
cord-018764-02l423mk	274	5	recover	recover	VERB
cord-018764-02l423mk	274	6	completely	completely	ADV
cord-018764-02l423mk	274	7	,	,	PUNCT
cord-018764-02l423mk	274	8	while	while	SCONJ
cord-018764-02l423mk	274	9	survivors	survivor	NOUN
cord-018764-02l423mk	274	10	of	of	ADP
cord-018764-02l423mk	274	11	severe	severe	ADJ
cord-018764-02l423mk	274	12	sae	sae	PROPN
cord-018764-02l423mk	274	13	may	may	AUX
cord-018764-02l423mk	274	14	have	have	VERB
cord-018764-02l423mk	274	15	persistent	persistent	ADJ
cord-018764-02l423mk	274	16	neurological	neurological	ADJ
cord-018764-02l423mk	274	17	deficit	deficit	NOUN
cord-018764-02l423mk	275	1	[	[	PUNCT
cord-018764-02l423mk	275	2	165	165	NUM
cord-018764-02l423mk	275	3	]	]	PUNCT
cord-018764-02l423mk	275	4	)	)	PUNCT
cord-018764-02l423mk	275	5	.	.	PUNCT
cord-018764-02l423mk	276	1	in	in	ADP
cord-018764-02l423mk	276	2	line	line	NOUN
cord-018764-02l423mk	276	3	with	with	ADP
cord-018764-02l423mk	276	4	adult	adult	NOUN
cord-018764-02l423mk	276	5	cm	cm	NOUN
cord-018764-02l423mk	276	6	,	,	PUNCT
cord-018764-02l423mk	276	7	the	the	DET
cord-018764-02l423mk	276	8	severity	severity	NOUN
cord-018764-02l423mk	276	9	of	of	ADP
cord-018764-02l423mk	276	10	encephalopathy	encephalopathy	ADJ
cord-018764-02l423mk	276	11	parallels	parallel	VERB
cord-018764-02l423mk	276	12	the	the	DET
cord-018764-02l423mk	276	13	severity	severity	NOUN
cord-018764-02l423mk	276	14	of	of	ADP
cord-018764-02l423mk	276	15	systemic	systemic	ADJ
cord-018764-02l423mk	276	16	organ	organ	NOUN
cord-018764-02l423mk	276	17	failure	failure	NOUN
cord-018764-02l423mk	276	18	[	[	PUNCT
cord-018764-02l423mk	276	19	141	141	NUM
cord-018764-02l423mk	276	20	]	]	PUNCT
cord-018764-02l423mk	276	21	.	.	PUNCT
cord-018764-02l423mk	277	1	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	277	2	cytokines	cytokine	NOUN
cord-018764-02l423mk	277	3	have	have	AUX
cord-018764-02l423mk	277	4	been	be	AUX
cord-018764-02l423mk	277	5	demonstrated	demonstrate	VERB
cord-018764-02l423mk	277	6	to	to	PART
cord-018764-02l423mk	277	7	be	be	AUX
cord-018764-02l423mk	277	8	higher	high	ADJ
cord-018764-02l423mk	277	9	in	in	ADP
cord-018764-02l423mk	277	10	the	the	DET
cord-018764-02l423mk	277	11	serum	serum	NOUN
cord-018764-02l423mk	277	12	than	than	ADP
cord-018764-02l423mk	277	13	in	in	ADP
cord-018764-02l423mk	277	14	the	the	DET
cord-018764-02l423mk	277	15	csf	csf	NOUN
cord-018764-02l423mk	277	16	,	,	PUNCT
cord-018764-02l423mk	277	17	suggesting	suggest	VERB
cord-018764-02l423mk	277	18	that	that	SCONJ
cord-018764-02l423mk	277	19	sepsis	sepsis	NOUN
cord-018764-02l423mk	277	20	encephalopathy	encephalopathy	ADJ
cord-018764-02l423mk	277	21	is	be	AUX
cord-018764-02l423mk	277	22	a	a	DET
cord-018764-02l423mk	277	23	consequence	consequence	NOUN
cord-018764-02l423mk	277	24	of	of	ADP
cord-018764-02l423mk	277	25	the	the	DET
cord-018764-02l423mk	277	26	systemic	systemic	ADJ
cord-018764-02l423mk	277	27	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	277	28	response	response	NOUN
cord-018764-02l423mk	277	29	to	to	ADP
cord-018764-02l423mk	277	30	infection	infection	NOUN
cord-018764-02l423mk	277	31	[	[	PUNCT
cord-018764-02l423mk	277	32	141	141	NUM
cord-018764-02l423mk	277	33	]	]	PUNCT
cord-018764-02l423mk	277	34	.	.	PUNCT
cord-018764-02l423mk	278	1	an	an	DET
cord-018764-02l423mk	278	2	animal	animal	NOUN
cord-018764-02l423mk	278	3	model	model	NOUN
cord-018764-02l423mk	278	4	in	in	ADP
cord-018764-02l423mk	278	5	which	which	PRON
cord-018764-02l423mk	278	6	prior	prior	ADJ
cord-018764-02l423mk	278	7	administration	administration	NOUN
cord-018764-02l423mk	278	8	of	of	ADP
cord-018764-02l423mk	278	9	a	a	DET
cord-018764-02l423mk	278	10	neutralising	neutralise	VERB
cord-018764-02l423mk	278	11	antibody	antibody	NOUN
cord-018764-02l423mk	278	12	to	to	ADP
cord-018764-02l423mk	278	13	tnf	tnf	PROPN
cord-018764-02l423mk	278	14	prevented	prevent	VERB
cord-018764-02l423mk	278	15	the	the	DET
cord-018764-02l423mk	278	16	sepsis	sepsis	NOUN
cord-018764-02l423mk	278	17	encephalopathy	encephalopathy	ADJ
cord-018764-02l423mk	278	18	of	of	ADP
cord-018764-02l423mk	278	19	pancreatitis	pancreatitis	NOUN
cord-018764-02l423mk	278	20	[	[	PUNCT
cord-018764-02l423mk	278	21	166	166	NUM
cord-018764-02l423mk	278	22	]	]	PUNCT
cord-018764-02l423mk	278	23	is	be	AUX
cord-018764-02l423mk	278	24	consistent	consistent	ADJ
cord-018764-02l423mk	278	25	with	with	ADP
cord-018764-02l423mk	278	26	this	this	PRON
cord-018764-02l423mk	278	27	.	.	PUNCT
cord-018764-02l423mk	279	1	further	far	ADV
cord-018764-02l423mk	279	2	postulated	postulate	VERB
cord-018764-02l423mk	279	3	reversible	reversible	ADJ
cord-018764-02l423mk	279	4	mechanisms	mechanism	NOUN
cord-018764-02l423mk	279	5	of	of	ADP
cord-018764-02l423mk	279	6	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	279	7	include	include	VERB
cord-018764-02l423mk	279	8	changes	change	NOUN
cord-018764-02l423mk	279	9	in	in	ADP
cord-018764-02l423mk	279	10	regional	regional	ADJ
cord-018764-02l423mk	279	11	cerebral	cerebral	ADJ
cord-018764-02l423mk	279	12	blood	blood	NOUN
cord-018764-02l423mk	279	13	flow	flow	NOUN
cord-018764-02l423mk	279	14	,	,	PUNCT
cord-018764-02l423mk	279	15	neurotransmitter	neurotransmitter	NOUN
cord-018764-02l423mk	279	16	imbalance	imbalance	NOUN
cord-018764-02l423mk	279	17	,	,	PUNCT
cord-018764-02l423mk	279	18	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	279	19	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	279	20	,	,	PUNCT
cord-018764-02l423mk	279	21	bbb	bbb	PROPN
cord-018764-02l423mk	279	22	impairment	impairment	PROPN
cord-018764-02l423mk	279	23	and	and	CCONJ
cord-018764-02l423mk	279	24	oxidative	oxidative	ADJ
cord-018764-02l423mk	279	25	stress	stress	NOUN
cord-018764-02l423mk	279	26	[	[	X
cord-018764-02l423mk	279	27	167	167	NUM
cord-018764-02l423mk	279	28	]	]	PUNCT
cord-018764-02l423mk	279	29	.	.	PUNCT
cord-018764-02l423mk	280	1	severe	severe	ADJ
cord-018764-02l423mk	280	2	influenza	influenza	NOUN
cord-018764-02l423mk	280	3	infection	infection	NOUN
cord-018764-02l423mk	280	4	can	can	AUX
cord-018764-02l423mk	280	5	present	present	VERB
cord-018764-02l423mk	280	6	with	with	ADP
cord-018764-02l423mk	280	7	encephalopathy	encephalopathy	ADJ
cord-018764-02l423mk	280	8	,	,	PUNCT
cord-018764-02l423mk	280	9	yet	yet	ADV
cord-018764-02l423mk	280	10	as	as	ADP
cord-018764-02l423mk	280	11	in	in	ADP
cord-018764-02l423mk	280	12	malaria	malaria	NOUN
cord-018764-02l423mk	280	13	,	,	PUNCT
cord-018764-02l423mk	280	14	the	the	DET
cord-018764-02l423mk	280	15	pathogen	pathogen	PROPN
cord-018764-02l423mk	280	16	is	be	AUX
cord-018764-02l423mk	280	17	not	not	PART
cord-018764-02l423mk	280	18	neuroinvasive	neuroinvasive	ADJ
cord-018764-02l423mk	281	1	[	[	X
cord-018764-02l423mk	281	2	168	168	NUM
cord-018764-02l423mk	281	3	]	]	PUNCT
cord-018764-02l423mk	281	4	.	.	PUNCT
cord-018764-02l423mk	282	1	seizures	seizure	NOUN
cord-018764-02l423mk	282	2	and	and	CCONJ
cord-018764-02l423mk	282	3	coma	coma	NOUN
cord-018764-02l423mk	282	4	occur	occur	VERB
cord-018764-02l423mk	282	5	after	after	ADP
cord-018764-02l423mk	282	6	high	high	ADJ
cord-018764-02l423mk	282	7	fever	fever	NOUN
cord-018764-02l423mk	282	8	[	[	PUNCT
cord-018764-02l423mk	282	9	169	169	NUM
cord-018764-02l423mk	282	10	]	]	PUNCT
cord-018764-02l423mk	282	11	,	,	PUNCT
cord-018764-02l423mk	282	12	commonly	commonly	ADV
cord-018764-02l423mk	282	13	accompanied	accompany	VERB
cord-018764-02l423mk	282	14	by	by	ADP
cord-018764-02l423mk	282	15	thrombocytopaenia	thrombocytopaenia	NOUN
cord-018764-02l423mk	283	1	[	[	PUNCT
cord-018764-02l423mk	283	2	169	169	NUM
cord-018764-02l423mk	283	3	]	]	PUNCT
cord-018764-02l423mk	283	4	,	,	PUNCT
cord-018764-02l423mk	283	5	with	with	ADP
cord-018764-02l423mk	283	6	metabolic	metabolic	ADJ
cord-018764-02l423mk	283	7	acidosis	acidosis	NOUN
cord-018764-02l423mk	283	8	and	and	CCONJ
cord-018764-02l423mk	283	9	hyperlactataemia	hyperlactataemia	NOUN
cord-018764-02l423mk	283	10	in	in	ADP
cord-018764-02l423mk	283	11	severe	severe	ADJ
cord-018764-02l423mk	283	12	cases	case	NOUN
cord-018764-02l423mk	283	13	(	(	PUNCT
cord-018764-02l423mk	283	14	t.	t.	PROPN
cord-018764-02l423mk	283	15	ichiyama	ichiyama	PROPN
cord-018764-02l423mk	283	16	,	,	PUNCT
cord-018764-02l423mk	283	17	personal	personal	ADJ
cord-018764-02l423mk	283	18	communication	communication	NOUN
cord-018764-02l423mk	283	19	)	)	PUNCT
cord-018764-02l423mk	283	20	.	.	PUNCT
cord-018764-02l423mk	284	1	similar	similar	ADJ
cord-018764-02l423mk	284	2	to	to	ADP
cord-018764-02l423mk	284	3	adult	adult	NOUN
cord-018764-02l423mk	284	4	malaria	malaria	NOUN
cord-018764-02l423mk	284	5	,	,	PUNCT
cord-018764-02l423mk	284	6	neurological	neurological	ADJ
cord-018764-02l423mk	284	7	sequelae	sequelae	PROPN
cord-018764-02l423mk	284	8	occur	occur	VERB
cord-018764-02l423mk	284	9	concurrently	concurrently	ADV
cord-018764-02l423mk	284	10	with	with	ADP
cord-018764-02l423mk	284	11	multiple	multiple	ADJ
cord-018764-02l423mk	284	12	organ	organ	NOUN
cord-018764-02l423mk	284	13	failure	failure	NOUN
cord-018764-02l423mk	284	14	[	[	X
cord-018764-02l423mk	284	15	170	170	NUM
cord-018764-02l423mk	284	16	]	]	PUNCT
cord-018764-02l423mk	284	17	.	.	PUNCT
cord-018764-02l423mk	285	1	tnf	tnf	PROPN
cord-018764-02l423mk	285	2	,	,	PUNCT
cord-018764-02l423mk	285	3	il-6	il-6	PROPN
cord-018764-02l423mk	285	4	,	,	PUNCT
cord-018764-02l423mk	285	5	stnfri	stnfri	VERB
cord-018764-02l423mk	285	6	,	,	PUNCT
cord-018764-02l423mk	285	7	and	and	CCONJ
cord-018764-02l423mk	285	8	soluble	soluble	ADJ
cord-018764-02l423mk	285	9	e	e	NOUN
cord-018764-02l423mk	285	10	-	-	NOUN
cord-018764-02l423mk	285	11	selectin	selectin	ADJ
cord-018764-02l423mk	285	12	are	be	AUX
cord-018764-02l423mk	285	13	increased	increase	VERB
cord-018764-02l423mk	285	14	in	in	ADP
cord-018764-02l423mk	285	15	serum	serum	NOUN
cord-018764-02l423mk	285	16	and	and	CCONJ
cord-018764-02l423mk	285	17	csf	csf	NOUN
cord-018764-02l423mk	285	18	[	[	PUNCT
cord-018764-02l423mk	285	19	171	171	NUM
cord-018764-02l423mk	285	20	,	,	PUNCT
cord-018764-02l423mk	285	21	172	172	NUM
cord-018764-02l423mk	285	22	]	]	PUNCT
cord-018764-02l423mk	285	23	,	,	PUNCT
cord-018764-02l423mk	285	24	and	and	CCONJ
cord-018764-02l423mk	285	25	serum	serum	NOUN
cord-018764-02l423mk	285	26	nitrite	nitrite	ADJ
cord-018764-02l423mk	285	27	/	/	SYM
cord-018764-02l423mk	285	28	nitrate	nitrate	NOUN
cord-018764-02l423mk	285	29	levels	level	NOUN
cord-018764-02l423mk	285	30	are	be	AUX
cord-018764-02l423mk	285	31	increased	increase	VERB
cord-018764-02l423mk	285	32	[	[	X
cord-018764-02l423mk	285	33	173	173	NUM
cord-018764-02l423mk	285	34	]	]	PUNCT
cord-018764-02l423mk	285	35	.	.	PUNCT
cord-018764-02l423mk	286	1	detailed	detailed	ADJ
cord-018764-02l423mk	286	2	examination	examination	NOUN
cord-018764-02l423mk	286	3	of	of	ADP
cord-018764-02l423mk	286	4	brain	brain	NOUN
cord-018764-02l423mk	286	5	has	have	AUX
cord-018764-02l423mk	286	6	revealed	reveal	VERB
cord-018764-02l423mk	286	7	apoptosis	apoptosis	NOUN
cord-018764-02l423mk	286	8	of	of	ADP
cord-018764-02l423mk	286	9	neurons	neuron	NOUN
cord-018764-02l423mk	286	10	and	and	CCONJ
cord-018764-02l423mk	286	11	glial	glial	ADJ
cord-018764-02l423mk	286	12	cell	cell	NOUN
cord-018764-02l423mk	286	13	,	,	PUNCT
cord-018764-02l423mk	286	14	histological	histological	ADJ
cord-018764-02l423mk	286	15	evidence	evidence	NOUN
cord-018764-02l423mk	286	16	of	of	ADP
cord-018764-02l423mk	286	17	active	active	ADJ
cord-018764-02l423mk	286	18	caspase-3	caspase-3	NOUN
cord-018764-02l423mk	286	19	and	and	CCONJ
cord-018764-02l423mk	286	20	caspase	caspase	NOUN
cord-018764-02l423mk	286	21	-	-	PUNCT
cord-018764-02l423mk	286	22	cleaved	cleave	VERB
cord-018764-02l423mk	286	23	parp	parp	NOUN
cord-018764-02l423mk	286	24	,	,	PUNCT
cord-018764-02l423mk	286	25	cerebral	cerebral	ADJ
cord-018764-02l423mk	286	26	oedema	oedema	NOUN
cord-018764-02l423mk	286	27	,	,	PUNCT
cord-018764-02l423mk	286	28	and	and	CCONJ
cord-018764-02l423mk	286	29	bbb	bbb	PROPN
cord-018764-02l423mk	286	30	impairment	impairment	PROPN
cord-018764-02l423mk	286	31	[	[	PUNCT
cord-018764-02l423mk	286	32	174	174	NUM
cord-018764-02l423mk	286	33	]	]	PUNCT
cord-018764-02l423mk	286	34	.	.	PUNCT
cord-018764-02l423mk	287	1	these	these	DET
cord-018764-02l423mk	287	2	parallel	parallel	ADJ
cord-018764-02l423mk	287	3	changes	change	NOUN
cord-018764-02l423mk	287	4	are	be	AUX
cord-018764-02l423mk	287	5	set	set	VERB
cord-018764-02l423mk	287	6	out	out	ADP
cord-018764-02l423mk	287	7	in	in	ADP
cord-018764-02l423mk	287	8	table	table	NOUN
cord-018764-02l423mk	287	9	3	3	NUM
cord-018764-02l423mk	287	10	.	.	PUNCT
cord-018764-02l423mk	288	1	it	it	PRON
cord-018764-02l423mk	288	2	is	be	AUX
cord-018764-02l423mk	288	3	clear	clear	ADJ
cord-018764-02l423mk	288	4	,	,	PUNCT
cord-018764-02l423mk	288	5	therefore	therefore	ADV
cord-018764-02l423mk	288	6	,	,	PUNCT
cord-018764-02l423mk	288	7	that	that	SCONJ
cord-018764-02l423mk	288	8	the	the	DET
cord-018764-02l423mk	288	9	presence	presence	NOUN
cord-018764-02l423mk	288	10	of	of	ADP
cord-018764-02l423mk	288	11	sequestering	sequester	VERB
cord-018764-02l423mk	288	12	parasitised	parasitise	VERB
cord-018764-02l423mk	288	13	red	red	ADJ
cord-018764-02l423mk	288	14	cells	cell	NOUN
cord-018764-02l423mk	288	15	is	be	AUX
cord-018764-02l423mk	288	16	not	not	PART
cord-018764-02l423mk	288	17	necessary	necessary	ADJ
cord-018764-02l423mk	288	18	to	to	PART
cord-018764-02l423mk	288	19	generate	generate	VERB
cord-018764-02l423mk	288	20	these	these	DET
cord-018764-02l423mk	288	21	changes	change	NOUN
cord-018764-02l423mk	288	22	,	,	PUNCT
cord-018764-02l423mk	288	23	which	which	PRON
cord-018764-02l423mk	288	24	are	be	AUX
cord-018764-02l423mk	288	25	also	also	ADV
cord-018764-02l423mk	288	26	demonstrable	demonstrable	ADJ
cord-018764-02l423mk	288	27	in	in	ADP
cord-018764-02l423mk	288	28	the	the	DET
cord-018764-02l423mk	288	29	falciparum	falciparum	NOUN
cord-018764-02l423mk	288	30	malaria	malaria	NOUN
cord-018764-02l423mk	288	31	encephalopathy	encephalopathy	ADJ
cord-018764-02l423mk	288	32	.	.	PUNCT
cord-018764-02l423mk	289	1	notably	notably	ADV
cord-018764-02l423mk	289	2	,	,	PUNCT
cord-018764-02l423mk	289	3	high	high	ADJ
cord-018764-02l423mk	289	4	levels	level	NOUN
cord-018764-02l423mk	289	5	of	of	ADP
cord-018764-02l423mk	289	6	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	289	7	cytokine	cytokine	NOUN
cord-018764-02l423mk	289	8	are	be	AUX
cord-018764-02l423mk	289	9	present	present	ADJ
cord-018764-02l423mk	289	10	in	in	ADP
cord-018764-02l423mk	289	11	each	each	DET
cord-018764-02l423mk	289	12	disease	disease	NOUN
cord-018764-02l423mk	289	13	.	.	PUNCT
cord-018764-02l423mk	290	1	seizures	seizure	NOUN
cord-018764-02l423mk	290	2	are	be	AUX
cord-018764-02l423mk	290	3	a	a	DET
cord-018764-02l423mk	290	4	very	very	ADV
cord-018764-02l423mk	290	5	common	common	ADJ
cord-018764-02l423mk	290	6	component	component	NOUN
cord-018764-02l423mk	290	7	of	of	ADP
cord-018764-02l423mk	290	8	acute	acute	ADJ
cord-018764-02l423mk	290	9	malaria	malaria	NOUN
cord-018764-02l423mk	290	10	illness	illness	NOUN
cord-018764-02l423mk	290	11	in	in	ADP
cord-018764-02l423mk	290	12	children	child	NOUN
cord-018764-02l423mk	290	13	.	.	PUNCT
cord-018764-02l423mk	291	1	a	a	DET
cord-018764-02l423mk	291	2	recent	recent	ADJ
cord-018764-02l423mk	291	3	review	review	NOUN
cord-018764-02l423mk	291	4	documented	document	VERB
cord-018764-02l423mk	291	5	that	that	SCONJ
cord-018764-02l423mk	291	6	80	80	NUM
cord-018764-02l423mk	291	7	%	%	NOUN
cord-018764-02l423mk	291	8	of	of	ADP
cord-018764-02l423mk	291	9	african	african	ADJ
cord-018764-02l423mk	291	10	children	child	NOUN
cord-018764-02l423mk	291	11	had	have	VERB
cord-018764-02l423mk	291	12	a	a	DET
cord-018764-02l423mk	291	13	history	history	NOUN
cord-018764-02l423mk	291	14	of	of	ADP
cord-018764-02l423mk	291	15	seizures	seizure	NOUN
cord-018764-02l423mk	291	16	,	,	PUNCT
cord-018764-02l423mk	291	17	with	with	ADP
cord-018764-02l423mk	291	18	60	60	NUM
cord-018764-02l423mk	291	19	%	%	NOUN
cord-018764-02l423mk	291	20	exhibiting	exhibit	VERB
cord-018764-02l423mk	291	21	seizures	seizure	NOUN
cord-018764-02l423mk	291	22	during	during	ADP
cord-018764-02l423mk	291	23	hospital	hospital	NOUN
cord-018764-02l423mk	291	24	admission	admission	NOUN
cord-018764-02l423mk	291	25	[	[	X
cord-018764-02l423mk	291	26	175	175	NUM
cord-018764-02l423mk	291	27	]	]	PUNCT
cord-018764-02l423mk	291	28	.	.	PUNCT
cord-018764-02l423mk	292	1	the	the	DET
cord-018764-02l423mk	292	2	molecular	molecular	ADJ
cord-018764-02l423mk	292	3	basis	basis	NOUN
cord-018764-02l423mk	292	4	of	of	ADP
cord-018764-02l423mk	292	5	the	the	DET
cord-018764-02l423mk	292	6	seizures	seizure	NOUN
cord-018764-02l423mk	292	7	is	be	AUX
cord-018764-02l423mk	292	8	unclear	unclear	ADJ
cord-018764-02l423mk	292	9	.	.	PUNCT
cord-018764-02l423mk	293	1	multiple	multiple	ADJ
cord-018764-02l423mk	293	2	mechanisms	mechanism	NOUN
cord-018764-02l423mk	293	3	have	have	AUX
cord-018764-02l423mk	293	4	been	be	AUX
cord-018764-02l423mk	293	5	postulated	postulate	VERB
cord-018764-02l423mk	293	6	,	,	PUNCT
cord-018764-02l423mk	293	7	including	include	VERB
cord-018764-02l423mk	293	8	fever	fever	NOUN
cord-018764-02l423mk	293	9	,	,	PUNCT
cord-018764-02l423mk	293	10	hypoxia	hypoxia	NOUN
cord-018764-02l423mk	293	11	and/or	and/or	CCONJ
cord-018764-02l423mk	293	12	cytokine	cytokine	NOUN
cord-018764-02l423mk	293	13	stimulation	stimulation	NOUN
cord-018764-02l423mk	293	14	leading	lead	VERB
cord-018764-02l423mk	293	15	to	to	ADP
cord-018764-02l423mk	293	16	an	an	DET
cord-018764-02l423mk	293	17	imbalance	imbalance	NOUN
cord-018764-02l423mk	293	18	of	of	ADP
cord-018764-02l423mk	293	19	neurotransmitters	neurotransmitter	NOUN
cord-018764-02l423mk	293	20	and	and	CCONJ
cord-018764-02l423mk	293	21	excitotoxins	excitotoxin	NOUN
cord-018764-02l423mk	293	22	or	or	CCONJ
cord-018764-02l423mk	293	23	neuronal	neuronal	ADJ
cord-018764-02l423mk	293	24	damage	damage	NOUN
cord-018764-02l423mk	293	25	[	[	PUNCT
cord-018764-02l423mk	293	26	11	11	NUM
cord-018764-02l423mk	293	27	,	,	PUNCT
cord-018764-02l423mk	293	28	148	148	NUM
cord-018764-02l423mk	293	29	]	]	PUNCT
cord-018764-02l423mk	293	30	.	.	PUNCT
cord-018764-02l423mk	294	1	recently	recently	ADV
cord-018764-02l423mk	294	2	,	,	PUNCT
cord-018764-02l423mk	294	3	lang	lang	PROPN
cord-018764-02l423mk	294	4	and	and	CCONJ
cord-018764-02l423mk	294	5	co	co	NOUN
cord-018764-02l423mk	294	6	-	-	NOUN
cord-018764-02l423mk	294	7	workers	worker	NOUN
cord-018764-02l423mk	294	8	[	[	PUNCT
cord-018764-02l423mk	294	9	176	176	NUM
cord-018764-02l423mk	294	10	]	]	PUNCT
cord-018764-02l423mk	294	11	demonstrated	demonstrate	VERB
cord-018764-02l423mk	294	12	that	that	SCONJ
cord-018764-02l423mk	294	13	falciparum	falciparum	NOUN
cord-018764-02l423mk	294	14	parasitaemia	parasitaemia	NOUN
cord-018764-02l423mk	294	15	is	be	AUX
cord-018764-02l423mk	294	16	associated	associate	VERB
cord-018764-02l423mk	294	17	with	with	ADP
cord-018764-02l423mk	294	18	the	the	DET
cord-018764-02l423mk	294	19	generation	generation	NOUN
cord-018764-02l423mk	294	20	of	of	ADP
cord-018764-02l423mk	294	21	specific	specific	ADJ
cord-018764-02l423mk	294	22	antibodies	antibody	NOUN
cord-018764-02l423mk	294	23	for	for	ADP
cord-018764-02l423mk	294	24	voltage	voltage	NOUN
cord-018764-02l423mk	294	25	-	-	PUNCT
cord-018764-02l423mk	294	26	gated	gate	VERB
cord-018764-02l423mk	294	27	calcium	calcium	NOUN
cord-018764-02l423mk	294	28	channels	channel	NOUN
cord-018764-02l423mk	294	29	directed	direct	VERB
cord-018764-02l423mk	294	30	against	against	ADP
cord-018764-02l423mk	294	31	neurones	neurone	NOUN
cord-018764-02l423mk	294	32	.	.	PUNCT
cord-018764-02l423mk	295	1	higher	high	ADJ
cord-018764-02l423mk	295	2	antibody	antibody	NOUN
cord-018764-02l423mk	295	3	concentrations	concentration	NOUN
cord-018764-02l423mk	295	4	were	be	AUX
cord-018764-02l423mk	295	5	detectable	detectable	ADJ
cord-018764-02l423mk	295	6	in	in	ADP
cord-018764-02l423mk	295	7	sera	sera	PROPN
cord-018764-02l423mk	295	8	from	from	ADP
cord-018764-02l423mk	295	9	patients	patient	NOUN
cord-018764-02l423mk	295	10	exhibiting	exhibit	VERB
cord-018764-02l423mk	295	11	cm	cm	NOUN
cord-018764-02l423mk	295	12	or	or	CCONJ
cord-018764-02l423mk	295	13	malaria	malaria	NOUN
cord-018764-02l423mk	295	14	with	with	ADP
cord-018764-02l423mk	295	15	seizures	seizure	NOUN
cord-018764-02l423mk	295	16	than	than	ADP
cord-018764-02l423mk	295	17	uncomplicated	uncomplicated	ADJ
cord-018764-02l423mk	295	18	malaria	malaria	NOUN
cord-018764-02l423mk	295	19	,	,	PUNCT
cord-018764-02l423mk	295	20	suggesting	suggest	VERB
cord-018764-02l423mk	295	21	that	that	SCONJ
cord-018764-02l423mk	295	22	these	these	DET
cord-018764-02l423mk	295	23	antibodies	antibody	NOUN
cord-018764-02l423mk	295	24	may	may	AUX
cord-018764-02l423mk	295	25	influence	influence	VERB
cord-018764-02l423mk	295	26	seizure	seizure	NOUN
cord-018764-02l423mk	295	27	propensity	propensity	NOUN
cord-018764-02l423mk	295	28	.	.	PUNCT
cord-018764-02l423mk	296	1	only	only	ADV
cord-018764-02l423mk	296	2	the	the	DET
cord-018764-02l423mk	296	3	erythrocytic	erythrocytic	ADJ
cord-018764-02l423mk	296	4	form	form	NOUN
cord-018764-02l423mk	296	5	of	of	ADP
cord-018764-02l423mk	296	6	malaria	malaria	NOUN
cord-018764-02l423mk	296	7	is	be	AUX
cord-018764-02l423mk	296	8	associated	associate	VERB
cord-018764-02l423mk	296	9	with	with	ADP
cord-018764-02l423mk	296	10	disease	disease	NOUN
cord-018764-02l423mk	296	11	,	,	PUNCT
cord-018764-02l423mk	296	12	so	so	ADV
cord-018764-02l423mk	296	13	valuable	valuable	ADJ
cord-018764-02l423mk	296	14	information	information	NOUN
cord-018764-02l423mk	296	15	about	about	ADP
cord-018764-02l423mk	296	16	which	which	PRON
cord-018764-02l423mk	296	17	african	african	ADJ
cord-018764-02l423mk	296	18	children	child	NOUN
cord-018764-02l423mk	296	19	are	be	AUX
cord-018764-02l423mk	296	20	likely	likely	ADJ
cord-018764-02l423mk	296	21	to	to	PART
cord-018764-02l423mk	296	22	have	have	VERB
cord-018764-02l423mk	296	23	more	more	ADJ
cord-018764-02l423mk	296	24	,	,	PUNCT
cord-018764-02l423mk	296	25	or	or	CCONJ
cord-018764-02l423mk	296	26	less	less	ADJ
cord-018764-02l423mk	296	27	,	,	PUNCT
cord-018764-02l423mk	296	28	severe	severe	ADJ
cord-018764-02l423mk	296	29	malaria	malaria	NOUN
cord-018764-02l423mk	296	30	has	have	AUX
cord-018764-02l423mk	296	31	inevitably	inevitably	ADV
cord-018764-02l423mk	296	32	been	be	AUX
cord-018764-02l423mk	296	33	obtained	obtain	VERB
cord-018764-02l423mk	296	34	from	from	ADP
cord-018764-02l423mk	296	35	examining	examine	VERB
cord-018764-02l423mk	296	36	the	the	DET
cord-018764-02l423mk	296	37	inborn	inborn	ADJ
cord-018764-02l423mk	296	38	rbc	rbc	PROPN
cord-018764-02l423mk	296	39	abnormalities	abnormality	NOUN
cord-018764-02l423mk	296	40	that	that	PRON
cord-018764-02l423mk	296	41	endemic	endemic	ADJ
cord-018764-02l423mk	296	42	malaria	malaria	NOUN
cord-018764-02l423mk	296	43	has	have	AUX
cord-018764-02l423mk	296	44	selected	select	VERB
cord-018764-02l423mk	296	45	across	across	ADP
cord-018764-02l423mk	296	46	the	the	DET
cord-018764-02l423mk	296	47	tropics	tropic	NOUN
cord-018764-02l423mk	296	48	.	.	PUNCT
cord-018764-02l423mk	297	1	the	the	DET
cord-018764-02l423mk	297	2	coinciding	coincide	VERB
cord-018764-02l423mk	297	3	geographic	geographic	ADJ
cord-018764-02l423mk	297	4	distributions	distribution	NOUN
cord-018764-02l423mk	297	5	of	of	ADP
cord-018764-02l423mk	297	6	malaria	malaria	NOUN
cord-018764-02l423mk	297	7	transmission	transmission	NOUN
cord-018764-02l423mk	297	8	and	and	CCONJ
cord-018764-02l423mk	297	9	the	the	DET
cord-018764-02l423mk	297	10	thalassaemias	thalassaemia	NOUN
cord-018764-02l423mk	297	11	prompted	prompt	VERB
cord-018764-02l423mk	297	12	haldane	haldane	NOUN
cord-018764-02l423mk	297	13	to	to	PART
cord-018764-02l423mk	297	14	put	put	VERB
cord-018764-02l423mk	297	15	forward	forward	ADV
cord-018764-02l423mk	297	16	the	the	DET
cord-018764-02l423mk	297	17	'	'	PUNCT
cord-018764-02l423mk	297	18	malaria	malaria	NOUN
cord-018764-02l423mk	297	19	hypothesis	hypothesis	NOUN
cord-018764-02l423mk	297	20	'	'	PUNCT
cord-018764-02l423mk	297	21	,	,	PUNCT
cord-018764-02l423mk	297	22	which	which	PRON
cord-018764-02l423mk	297	23	proposed	propose	VERB
cord-018764-02l423mk	297	24	that	that	SCONJ
cord-018764-02l423mk	297	25	common	common	ADJ
cord-018764-02l423mk	297	26	erythrocyte	erythrocyte	NOUN
cord-018764-02l423mk	297	27	abnormalities	abnormality	NOUN
cord-018764-02l423mk	297	28	are	be	AUX
cord-018764-02l423mk	297	29	selected	select	VERB
cord-018764-02l423mk	297	30	because	because	SCONJ
cord-018764-02l423mk	297	31	of	of	ADP
cord-018764-02l423mk	297	32	the	the	DET
cord-018764-02l423mk	297	33	fitness	fitness	NOUN
cord-018764-02l423mk	297	34	advantage	advantage	NOUN
cord-018764-02l423mk	297	35	they	they	PRON
cord-018764-02l423mk	297	36	confer	confer	VERB
cord-018764-02l423mk	297	37	against	against	ADP
cord-018764-02l423mk	297	38	malaria	malaria	NOUN
cord-018764-02l423mk	297	39	[	[	PUNCT
cord-018764-02l423mk	297	40	177	177	NUM
cord-018764-02l423mk	297	41	]	]	PUNCT
cord-018764-02l423mk	297	42	.	.	PUNCT
cord-018764-02l423mk	298	1	sickle	sickle	ADJ
cord-018764-02l423mk	298	2	cell	cell	NOUN
cord-018764-02l423mk	298	3	haemoglobin	haemoglobin	NOUN
cord-018764-02l423mk	298	4	(	(	PUNCT
cord-018764-02l423mk	298	5	hbs	hbs	PROPN
cord-018764-02l423mk	298	6	)	)	PUNCT
cord-018764-02l423mk	298	7	has	have	AUX
cord-018764-02l423mk	298	8	also	also	ADV
cord-018764-02l423mk	298	9	been	be	AUX
cord-018764-02l423mk	298	10	repeatedly	repeatedly	ADV
cord-018764-02l423mk	298	11	shown	show	VERB
cord-018764-02l423mk	298	12	to	to	PART
cord-018764-02l423mk	298	13	be	be	AUX
cord-018764-02l423mk	298	14	associated	associate	VERB
cord-018764-02l423mk	298	15	with	with	ADP
cord-018764-02l423mk	298	16	malaria	malaria	NOUN
cord-018764-02l423mk	298	17	resistance	resistance	NOUN
cord-018764-02l423mk	298	18	,	,	PUNCT
cord-018764-02l423mk	298	19	with	with	ADP
cord-018764-02l423mk	298	20	heterozygotes	heterozygote	NOUN
cord-018764-02l423mk	298	21	for	for	ADP
cord-018764-02l423mk	298	22	the	the	DET
cord-018764-02l423mk	298	23	hbs	hbs	PROPN
cord-018764-02l423mk	298	24	trait	trait	NOUN
cord-018764-02l423mk	298	25	demonstrating	demonstrate	VERB
cord-018764-02l423mk	298	26	10	10	NUM
cord-018764-02l423mk	298	27	%	%	NOUN
cord-018764-02l423mk	298	28	of	of	ADP
cord-018764-02l423mk	298	29	the	the	DET
cord-018764-02l423mk	298	30	population	population	NOUN
cord-018764-02l423mk	298	31	at	at	ADP
cord-018764-02l423mk	298	32	risk	risk	NOUN
cord-018764-02l423mk	298	33	for	for	ADP
cord-018764-02l423mk	298	34	severe	severe	ADJ
cord-018764-02l423mk	298	35	malaria	malaria	NOUN
cord-018764-02l423mk	298	36	in	in	ADP
cord-018764-02l423mk	298	37	certain	certain	ADJ
cord-018764-02l423mk	298	38	populations	population	NOUN
cord-018764-02l423mk	298	39	[	[	PUNCT
cord-018764-02l423mk	298	40	178	178	NUM
cord-018764-02l423mk	298	41	]	]	PUNCT
cord-018764-02l423mk	298	42	.	.	PUNCT
cord-018764-02l423mk	299	1	other	other	ADJ
cord-018764-02l423mk	299	2	haemoglobinopathies	haemoglobinopathy	NOUN
cord-018764-02l423mk	299	3	(	(	PUNCT
cord-018764-02l423mk	299	4	e.g.	e.g.	ADV
cord-018764-02l423mk	299	5	hbc	hbc	NOUN
cord-018764-02l423mk	300	1	[	[	PUNCT
cord-018764-02l423mk	300	2	179	179	NUM
cord-018764-02l423mk	300	3	,	,	PUNCT
cord-018764-02l423mk	300	4	180	180	NUM
cord-018764-02l423mk	300	5	]	]	PUNCT
cord-018764-02l423mk	300	6	and	and	CCONJ
cord-018764-02l423mk	300	7	hbe	hbe	NOUN
cord-018764-02l423mk	301	1	[	[	X
cord-018764-02l423mk	301	2	181	181	NUM
cord-018764-02l423mk	301	3	]	]	PUNCT
cord-018764-02l423mk	301	4	)	)	PUNCT
cord-018764-02l423mk	301	5	and	and	CCONJ
cord-018764-02l423mk	301	6	deficiencies	deficiency	NOUN
cord-018764-02l423mk	301	7	in	in	ADP
cord-018764-02l423mk	301	8	rbc	rbc	PROPN
cord-018764-02l423mk	301	9	enzymes	enzyme	NOUN
cord-018764-02l423mk	301	10	(	(	PUNCT
cord-018764-02l423mk	301	11	e.g.	e.g.	ADV
cord-018764-02l423mk	301	12	glucose-6	glucose-6	NUM
cord-018764-02l423mk	301	13	-	-	PUNCT
cord-018764-02l423mk	301	14	phosphate	phosphate	NOUN
cord-018764-02l423mk	301	15	dehydrogenase	dehydrogenase	NOUN
cord-018764-02l423mk	301	16	deficiency	deficiency	NOUN
cord-018764-02l423mk	301	17	[	[	PUNCT
cord-018764-02l423mk	301	18	182	182	NUM
cord-018764-02l423mk	301	19	]	]	PUNCT
cord-018764-02l423mk	301	20	)	)	PUNCT
cord-018764-02l423mk	301	21	have	have	AUX
cord-018764-02l423mk	301	22	also	also	ADV
cord-018764-02l423mk	301	23	been	be	AUX
cord-018764-02l423mk	301	24	linked	link	VERB
cord-018764-02l423mk	301	25	with	with	ADP
cord-018764-02l423mk	301	26	protection	protection	NOUN
cord-018764-02l423mk	301	27	against	against	ADP
cord-018764-02l423mk	301	28	severe	severe	ADJ
cord-018764-02l423mk	301	29	malaria	malaria	NOUN
cord-018764-02l423mk	301	30	.	.	PUNCT
cord-018764-02l423mk	302	1	the	the	DET
cord-018764-02l423mk	302	2	mechanisms	mechanism	NOUN
cord-018764-02l423mk	302	3	of	of	ADP
cord-018764-02l423mk	302	4	protection	protection	NOUN
cord-018764-02l423mk	302	5	afforded	afford	VERB
cord-018764-02l423mk	302	6	by	by	ADP
cord-018764-02l423mk	302	7	haemoglobinopathies	haemoglobinopathy	NOUN
cord-018764-02l423mk	302	8	are	be	AUX
cord-018764-02l423mk	302	9	likely	likely	ADJ
cord-018764-02l423mk	302	10	to	to	PART
cord-018764-02l423mk	302	11	be	be	AUX
cord-018764-02l423mk	302	12	multi	multi	ADJ
cord-018764-02l423mk	302	13	-	-	ADJ
cord-018764-02l423mk	302	14	factorial	factorial	ADJ
cord-018764-02l423mk	302	15	.	.	PUNCT
cord-018764-02l423mk	303	1	studies	study	NOUN
cord-018764-02l423mk	303	2	have	have	AUX
cord-018764-02l423mk	303	3	demonstrated	demonstrate	VERB
cord-018764-02l423mk	303	4	evidence	evidence	NOUN
cord-018764-02l423mk	303	5	to	to	PART
cord-018764-02l423mk	303	6	support	support	VERB
cord-018764-02l423mk	303	7	several	several	ADJ
cord-018764-02l423mk	303	8	independent	independent	ADJ
cord-018764-02l423mk	303	9	mechanisms	mechanism	NOUN
cord-018764-02l423mk	303	10	including	include	VERB
cord-018764-02l423mk	303	11	:	:	PUNCT
cord-018764-02l423mk	303	12	reduced	reduce	VERB
cord-018764-02l423mk	303	13	parasite	parasite	ADJ
cord-018764-02l423mk	303	14	invasion	invasion	NOUN
cord-018764-02l423mk	303	15	of	of	ADP
cord-018764-02l423mk	303	16	rbcs	rbc	NOUN
cord-018764-02l423mk	303	17	and	and	CCONJ
cord-018764-02l423mk	303	18	diminished	diminish	VERB
cord-018764-02l423mk	303	19	intraerythrocytic	intraerythrocytic	ADJ
cord-018764-02l423mk	303	20	growth	growth	NOUN
cord-018764-02l423mk	303	21	of	of	ADP
cord-018764-02l423mk	303	22	parasites	parasite	NOUN
cord-018764-02l423mk	303	23	in	in	ADP
cord-018764-02l423mk	303	24	patients	patient	NOUN
cord-018764-02l423mk	303	25	with	with	ADP
cord-018764-02l423mk	303	26	the	the	DET
cord-018764-02l423mk	303	27	hbs	hbs	PROPN
cord-018764-02l423mk	303	28	trait	trait	NOUN
cord-018764-02l423mk	304	1	[	[	PUNCT
cord-018764-02l423mk	304	2	183	183	NUM
cord-018764-02l423mk	304	3	]	]	PUNCT
cord-018764-02l423mk	304	4	,	,	PUNCT
cord-018764-02l423mk	304	5	enhanced	enhance	VERB
cord-018764-02l423mk	304	6	phagocytosis	phagocytosis	NOUN
cord-018764-02l423mk	304	7	of	of	ADP
cord-018764-02l423mk	304	8	parasite	parasite	NOUN
cord-018764-02l423mk	304	9	-	-	PUNCT
cord-018764-02l423mk	304	10	infected	infect	VERB
cord-018764-02l423mk	304	11	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	304	12	(	(	PUNCT
cord-018764-02l423mk	304	13	ies	ies	X
cord-018764-02l423mk	304	14	)	)	PUNCT
cord-018764-02l423mk	305	1	[	[	PUNCT
cord-018764-02l423mk	305	2	184	184	NUM
cord-018764-02l423mk	305	3	]	]	PUNCT
cord-018764-02l423mk	305	4	and	and	CCONJ
cord-018764-02l423mk	305	5	enhanced	enhance	VERB
cord-018764-02l423mk	305	6	immune	immune	ADJ
cord-018764-02l423mk	305	7	responses	response	NOUN
cord-018764-02l423mk	305	8	against	against	ADP
cord-018764-02l423mk	305	9	ies	ies	PROPN
cord-018764-02l423mk	306	1	[	[	X
cord-018764-02l423mk	306	2	185	185	NUM
cord-018764-02l423mk	306	3	]	]	PUNCT
cord-018764-02l423mk	306	4	.	.	PUNCT
cord-018764-02l423mk	307	1	recent	recent	ADJ
cord-018764-02l423mk	307	2	in	in	X
cord-018764-02l423mk	307	3	vitro	vitro	X
cord-018764-02l423mk	307	4	studies	study	NOUN
cord-018764-02l423mk	307	5	observed	observe	VERB
cord-018764-02l423mk	307	6	that	that	SCONJ
cord-018764-02l423mk	307	7	hbc	hbc	NOUN
cord-018764-02l423mk	307	8	modifies	modify	VERB
cord-018764-02l423mk	307	9	the	the	DET
cord-018764-02l423mk	307	10	quantity	quantity	NOUN
cord-018764-02l423mk	307	11	and	and	CCONJ
cord-018764-02l423mk	307	12	distribution	distribution	NOUN
cord-018764-02l423mk	307	13	of	of	ADP
cord-018764-02l423mk	307	14	the	the	DET
cord-018764-02l423mk	307	15	variant	variant	ADJ
cord-018764-02l423mk	307	16	antigen	antigen	NOUN
cord-018764-02l423mk	307	17	p.	p.	NOUN
cord-018764-02l423mk	307	18	falciparum	falciparum	NOUN
cord-018764-02l423mk	307	19	erythrocyte	erythrocyte	NOUN
cord-018764-02l423mk	307	20	membrane	membrane	NOUN
cord-018764-02l423mk	307	21	protein	protein	NOUN
cord-018764-02l423mk	307	22	1(pfemp1	1(pfemp1	NOUN
cord-018764-02l423mk	307	23	)	)	PUNCT
cord-018764-02l423mk	307	24	on	on	ADP
cord-018764-02l423mk	307	25	the	the	DET
cord-018764-02l423mk	307	26	ie	ie	PROPN
cord-018764-02l423mk	307	27	surface	surface	NOUN
cord-018764-02l423mk	307	28	.	.	PUNCT
cord-018764-02l423mk	308	1	pfemp1	pfemp1	NOUN
cord-018764-02l423mk	308	2	has	have	AUX
cord-018764-02l423mk	308	3	been	be	AUX
cord-018764-02l423mk	308	4	implicated	implicate	VERB
cord-018764-02l423mk	308	5	in	in	ADP
cord-018764-02l423mk	308	6	numerous	numerous	ADJ
cord-018764-02l423mk	308	7	ie	ie	X
cord-018764-02l423mk	308	8	adhesive	adhesive	ADJ
cord-018764-02l423mk	308	9	interactions	interaction	NOUN
cord-018764-02l423mk	308	10	.	.	PUNCT
cord-018764-02l423mk	309	1	in	in	ADP
cord-018764-02l423mk	309	2	the	the	DET
cord-018764-02l423mk	309	3	latter	latter	ADJ
cord-018764-02l423mk	309	4	study	study	NOUN
cord-018764-02l423mk	309	5	the	the	DET
cord-018764-02l423mk	309	6	authors	author	NOUN
cord-018764-02l423mk	309	7	demonstrated	demonstrate	VERB
cord-018764-02l423mk	309	8	that	that	SCONJ
cord-018764-02l423mk	309	9	hbc	hbc	NOUN
cord-018764-02l423mk	309	10	reduces	reduce	VERB
cord-018764-02l423mk	309	11	the	the	DET
cord-018764-02l423mk	309	12	level	level	NOUN
cord-018764-02l423mk	309	13	of	of	ADP
cord-018764-02l423mk	309	14	ie	ie	X
cord-018764-02l423mk	309	15	adhesion	adhesion	NOUN
cord-018764-02l423mk	309	16	to	to	ADP
cord-018764-02l423mk	309	17	endothelial	endothelial	ADJ
cord-018764-02l423mk	309	18	monolayers	monolayer	NOUN
cord-018764-02l423mk	309	19	,	,	PUNCT
cord-018764-02l423mk	309	20	in	in	ADP
cord-018764-02l423mk	309	21	addition	addition	NOUN
cord-018764-02l423mk	309	22	to	to	ADP
cord-018764-02l423mk	309	23	ie	ie	ADV
cord-018764-02l423mk	309	24	rosetting	rosette	VERB
cord-018764-02l423mk	309	25	(	(	PUNCT
cord-018764-02l423mk	309	26	the	the	DET
cord-018764-02l423mk	309	27	adhesion	adhesion	NOUN
cord-018764-02l423mk	309	28	of	of	ADP
cord-018764-02l423mk	309	29	ies	ie	NOUN
cord-018764-02l423mk	309	30	to	to	ADP
cord-018764-02l423mk	309	31	uninfected	uninfected	ADJ
cord-018764-02l423mk	309	32	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	309	33	)	)	PUNCT
cord-018764-02l423mk	309	34	and	and	CCONJ
cord-018764-02l423mk	309	35	ie	ie	ADV
cord-018764-02l423mk	309	36	agglutination	agglutination	NOUN
cord-018764-02l423mk	309	37	by	by	ADP
cord-018764-02l423mk	309	38	sera	sera	PROPN
cord-018764-02l423mk	309	39	.	.	PUNCT
cord-018764-02l423mk	310	1	these	these	DET
cord-018764-02l423mk	310	2	findings	finding	NOUN
cord-018764-02l423mk	310	3	provide	provide	VERB
cord-018764-02l423mk	310	4	the	the	DET
cord-018764-02l423mk	310	5	prospect	prospect	NOUN
cord-018764-02l423mk	310	6	that	that	SCONJ
cord-018764-02l423mk	310	7	hbc	hbc	PROPN
cord-018764-02l423mk	310	8	pro	pro	NOUN
cord-018764-02l423mk	310	9	-	-	NOUN
cord-018764-02l423mk	310	10	tects	tect	NOUN
cord-018764-02l423mk	310	11	against	against	ADP
cord-018764-02l423mk	310	12	severe	severe	ADJ
cord-018764-02l423mk	310	13	malaria	malaria	NOUN
cord-018764-02l423mk	310	14	by	by	ADP
cord-018764-02l423mk	310	15	mitigating	mitigate	VERB
cord-018764-02l423mk	310	16	the	the	DET
cord-018764-02l423mk	310	17	obstruction	obstruction	NOUN
cord-018764-02l423mk	310	18	and	and	CCONJ
cord-018764-02l423mk	310	19	inflammation	inflammation	NOUN
cord-018764-02l423mk	310	20	caused	cause	VERB
cord-018764-02l423mk	310	21	by	by	ADP
cord-018764-02l423mk	310	22	the	the	DET
cord-018764-02l423mk	310	23	pfemp1	pfemp1	ADV
cord-018764-02l423mk	310	24	-	-	PUNCT
cord-018764-02l423mk	310	25	mediated	mediate	VERB
cord-018764-02l423mk	310	26	adherence	adherence	NOUN
cord-018764-02l423mk	310	27	of	of	ADP
cord-018764-02l423mk	310	28	ies	ies	PROPN
cord-018764-02l423mk	311	1	[	[	X
cord-018764-02l423mk	311	2	186	186	NUM
cord-018764-02l423mk	311	3	]	]	PUNCT
cord-018764-02l423mk	311	4	.	.	PUNCT
cord-018764-02l423mk	312	1	however	however	ADV
cord-018764-02l423mk	312	2	,	,	PUNCT
cord-018764-02l423mk	312	3	sequestration	sequestration	NOUN
cord-018764-02l423mk	312	4	is	be	AUX
cord-018764-02l423mk	312	5	believed	believe	VERB
cord-018764-02l423mk	312	6	to	to	PART
cord-018764-02l423mk	312	7	enhance	enhance	VERB
cord-018764-02l423mk	312	8	parasite	parasite	ADJ
cord-018764-02l423mk	312	9	survival	survival	NOUN
cord-018764-02l423mk	312	10	by	by	ADP
cord-018764-02l423mk	312	11	enabling	enable	VERB
cord-018764-02l423mk	312	12	ies	ie	NOUN
cord-018764-02l423mk	312	13	to	to	PART
cord-018764-02l423mk	312	14	avoid	avoid	VERB
cord-018764-02l423mk	312	15	splenic	splenic	ADJ
cord-018764-02l423mk	312	16	clearance	clearance	NOUN
cord-018764-02l423mk	312	17	,	,	PUNCT
cord-018764-02l423mk	312	18	so	so	CCONJ
cord-018764-02l423mk	312	19	any	any	DET
cord-018764-02l423mk	312	20	reduction	reduction	NOUN
cord-018764-02l423mk	312	21	of	of	ADP
cord-018764-02l423mk	312	22	sequestration	sequestration	NOUN
cord-018764-02l423mk	312	23	by	by	ADP
cord-018764-02l423mk	312	24	hbc	hbc	PROPN
cord-018764-02l423mk	312	25	can	can	AUX
cord-018764-02l423mk	312	26	be	be	AUX
cord-018764-02l423mk	312	27	expected	expect	VERB
cord-018764-02l423mk	312	28	to	to	PART
cord-018764-02l423mk	312	29	limit	limit	VERB
cord-018764-02l423mk	312	30	parasite	parasite	PROPN
cord-018764-02l423mk	312	31	fitness	fitness	NOUN
cord-018764-02l423mk	312	32	.	.	PUNCT
cord-018764-02l423mk	313	1	multiple	multiple	ADJ
cord-018764-02l423mk	313	2	epidemiology	epidemiology	NOUN
cord-018764-02l423mk	313	3	studies	study	NOUN
cord-018764-02l423mk	313	4	(	(	PUNCT
cord-018764-02l423mk	313	5	e.g.	e.g.	ADV
cord-018764-02l423mk	313	6	[	[	X
cord-018764-02l423mk	313	7	179	179	NUM
cord-018764-02l423mk	313	8	,	,	PUNCT
cord-018764-02l423mk	313	9	187	187	NUM
cord-018764-02l423mk	313	10	,	,	PUNCT
cord-018764-02l423mk	313	11	188	188	NUM
cord-018764-02l423mk	313	12	]	]	PUNCT
cord-018764-02l423mk	313	13	)	)	PUNCT
cord-018764-02l423mk	313	14	have	have	AUX
cord-018764-02l423mk	313	15	failed	fail	VERB
cord-018764-02l423mk	313	16	to	to	PART
cord-018764-02l423mk	313	17	identify	identify	VERB
cord-018764-02l423mk	313	18	any	any	DET
cord-018764-02l423mk	313	19	significant	significant	ADJ
cord-018764-02l423mk	313	20	impact	impact	NOUN
cord-018764-02l423mk	313	21	of	of	ADP
cord-018764-02l423mk	313	22	hbc	hbc	NOUN
cord-018764-02l423mk	313	23	on	on	ADP
cord-018764-02l423mk	313	24	the	the	DET
cord-018764-02l423mk	313	25	frequency	frequency	NOUN
cord-018764-02l423mk	313	26	or	or	CCONJ
cord-018764-02l423mk	313	27	density	density	NOUN
cord-018764-02l423mk	313	28	of	of	ADP
cord-018764-02l423mk	313	29	parasitaemia	parasitaemia	NOUN
cord-018764-02l423mk	313	30	in	in	ADP
cord-018764-02l423mk	313	31	naturally	naturally	ADV
cord-018764-02l423mk	313	32	exposed	expose	VERB
cord-018764-02l423mk	313	33	populations	population	NOUN
cord-018764-02l423mk	313	34	.	.	PUNCT
cord-018764-02l423mk	314	1	consequently	consequently	ADV
cord-018764-02l423mk	314	2	,	,	PUNCT
cord-018764-02l423mk	314	3	the	the	DET
cord-018764-02l423mk	314	4	influence	influence	NOUN
cord-018764-02l423mk	314	5	of	of	ADP
cord-018764-02l423mk	314	6	the	the	DET
cord-018764-02l423mk	314	7	changes	change	NOUN
cord-018764-02l423mk	314	8	in	in	ADP
cord-018764-02l423mk	314	9	ie	ie	PROPN
cord-018764-02l423mk	314	10	surface	surface	NOUN
cord-018764-02l423mk	314	11	conformation	conformation	NOUN
cord-018764-02l423mk	314	12	needs	need	VERB
cord-018764-02l423mk	314	13	to	to	PART
cord-018764-02l423mk	314	14	be	be	AUX
cord-018764-02l423mk	314	15	confirmed	confirm	VERB
cord-018764-02l423mk	314	16	and	and	CCONJ
cord-018764-02l423mk	314	17	further	far	ADV
cord-018764-02l423mk	314	18	examined	examine	VERB
cord-018764-02l423mk	314	19	in	in	ADP
cord-018764-02l423mk	314	20	vivo	vivo	NOUN
cord-018764-02l423mk	314	21	[	[	X
cord-018764-02l423mk	314	22	189	189	NUM
cord-018764-02l423mk	314	23	]	]	PUNCT
cord-018764-02l423mk	314	24	.	.	PUNCT
cord-018764-02l423mk	315	1	a	a	DET
cord-018764-02l423mk	315	2	recent	recent	ADJ
cord-018764-02l423mk	315	3	study	study	NOUN
cord-018764-02l423mk	315	4	re	re	VERB
cord-018764-02l423mk	315	5	-	-	VERB
cord-018764-02l423mk	315	6	confirmed	confirm	VERB
cord-018764-02l423mk	315	7	that	that	SCONJ
cord-018764-02l423mk	315	8	african	african	ADJ
cord-018764-02l423mk	315	9	children	child	NOUN
cord-018764-02l423mk	315	10	with	with	ADP
cord-018764-02l423mk	315	11	-thalassaemia	-thalassaemia	ADJ
cord-018764-02l423mk	315	12	trait	trait	NOUN
cord-018764-02l423mk	315	13	are	be	AUX
cord-018764-02l423mk	315	14	significantly	significantly	ADV
cord-018764-02l423mk	315	15	less	less	ADV
cord-018764-02l423mk	315	16	likely	likely	ADJ
cord-018764-02l423mk	315	17	to	to	PART
cord-018764-02l423mk	315	18	be	be	AUX
cord-018764-02l423mk	315	19	hospitalised	hospitalise	VERB
cord-018764-02l423mk	315	20	with	with	ADP
cord-018764-02l423mk	315	21	severe	severe	ADJ
cord-018764-02l423mk	315	22	malaria	malaria	NOUN
cord-018764-02l423mk	315	23	,	,	PUNCT
cord-018764-02l423mk	315	24	particularly	particularly	ADV
cord-018764-02l423mk	315	25	with	with	ADP
cord-018764-02l423mk	315	26	coma	coma	NOUN
cord-018764-02l423mk	315	27	or	or	CCONJ
cord-018764-02l423mk	315	28	severe	severe	ADJ
cord-018764-02l423mk	315	29	anaemia	anaemia	NOUN
cord-018764-02l423mk	315	30	(	(	PUNCT
cord-018764-02l423mk	315	31	hb	hb	PROPN
cord-018764-02l423mk	315	32	<	<	X
cord-018764-02l423mk	315	33	5	5	NUM
cord-018764-02l423mk	315	34	g/100	g/100	PROPN
cord-018764-02l423mk	315	35	ml	ml	PROPN
cord-018764-02l423mk	315	36	)	)	PUNCT
cord-018764-02l423mk	315	37	.	.	PUNCT
cord-018764-02l423mk	316	1	it	it	PRON
cord-018764-02l423mk	316	2	is	be	AUX
cord-018764-02l423mk	316	3	intriguing	intriguing	ADJ
cord-018764-02l423mk	316	4	that	that	SCONJ
cord-018764-02l423mk	316	5	the	the	DET
cord-018764-02l423mk	316	6	-thalassaemia	-thalassaemia	NOUN
cord-018764-02l423mk	316	7	patients	patient	NOUN
cord-018764-02l423mk	316	8	did	do	AUX
cord-018764-02l423mk	316	9	not	not	PART
cord-018764-02l423mk	316	10	demonstrate	demonstrate	VERB
cord-018764-02l423mk	316	11	a	a	DET
cord-018764-02l423mk	316	12	lower	low	ADJ
cord-018764-02l423mk	316	13	incidence	incidence	NOUN
cord-018764-02l423mk	316	14	of	of	ADP
cord-018764-02l423mk	316	15	uncomplicated	uncomplicated	ADJ
cord-018764-02l423mk	316	16	malaria	malaria	NOUN
cord-018764-02l423mk	316	17	nor	nor	CCONJ
cord-018764-02l423mk	316	18	any	any	DET
cord-018764-02l423mk	316	19	reduction	reduction	NOUN
cord-018764-02l423mk	316	20	in	in	ADP
cord-018764-02l423mk	316	21	peripheral	peripheral	ADJ
cord-018764-02l423mk	316	22	parasite	parasite	NOUN
cord-018764-02l423mk	316	23	density	density	NOUN
cord-018764-02l423mk	317	1	[	[	X
cord-018764-02l423mk	317	2	190	190	NUM
cord-018764-02l423mk	317	3	]	]	PUNCT
cord-018764-02l423mk	317	4	.	.	PUNCT
cord-018764-02l423mk	318	1	thalassaemia	thalassaemia	NOUN
cord-018764-02l423mk	318	2	has	have	AUX
cord-018764-02l423mk	318	3	also	also	ADV
cord-018764-02l423mk	318	4	been	be	AUX
cord-018764-02l423mk	318	5	associated	associate	VERB
cord-018764-02l423mk	318	6	with	with	ADP
cord-018764-02l423mk	318	7	increased	increase	VERB
cord-018764-02l423mk	318	8	incidence	incidence	NOUN
cord-018764-02l423mk	318	9	of	of	ADP
cord-018764-02l423mk	318	10	clinical	clinical	ADJ
cord-018764-02l423mk	318	11	vivax	vivax	NOUN
cord-018764-02l423mk	318	12	and	and	CCONJ
cord-018764-02l423mk	318	13	falciparum	falciparum	NOUN
cord-018764-02l423mk	318	14	malaria	malaria	NOUN
cord-018764-02l423mk	318	15	during	during	ADP
cord-018764-02l423mk	318	16	early	early	ADJ
cord-018764-02l423mk	318	17	life	life	NOUN
cord-018764-02l423mk	318	18	[	[	PUNCT
cord-018764-02l423mk	318	19	191	191	NUM
cord-018764-02l423mk	318	20	]	]	PUNCT
cord-018764-02l423mk	318	21	.	.	PUNCT
cord-018764-02l423mk	319	1	the	the	DET
cord-018764-02l423mk	319	2	findings	finding	NOUN
cord-018764-02l423mk	319	3	raise	raise	VERB
cord-018764-02l423mk	319	4	speculation	speculation	NOUN
cord-018764-02l423mk	319	5	that	that	SCONJ
cord-018764-02l423mk	319	6	the	the	DET
cord-018764-02l423mk	319	7	trait	trait	NOUN
cord-018764-02l423mk	319	8	may	may	AUX
cord-018764-02l423mk	319	9	indirectly	indirectly	ADV
cord-018764-02l423mk	319	10	afford	afford	VERB
cord-018764-02l423mk	319	11	enhanced	enhance	VERB
cord-018764-02l423mk	319	12	immunity	immunity	NOUN
cord-018764-02l423mk	319	13	through	through	ADP
cord-018764-02l423mk	319	14	increased	increase	VERB
cord-018764-02l423mk	319	15	non	non	ADJ
cord-018764-02l423mk	319	16	-	-	ADJ
cord-018764-02l423mk	319	17	lethal	lethal	ADJ
cord-018764-02l423mk	319	18	exposure	exposure	NOUN
cord-018764-02l423mk	319	19	to	to	ADP
cord-018764-02l423mk	319	20	malarial	malarial	ADJ
cord-018764-02l423mk	319	21	parasites	parasite	NOUN
cord-018764-02l423mk	319	22	.	.	PUNCT
cord-018764-02l423mk	320	1	such	such	DET
cord-018764-02l423mk	320	2	a	a	DET
cord-018764-02l423mk	320	3	mechanism	mechanism	NOUN
cord-018764-02l423mk	320	4	is	be	AUX
cord-018764-02l423mk	320	5	appealing	appeal	VERB
cord-018764-02l423mk	320	6	,	,	PUNCT
cord-018764-02l423mk	320	7	since	since	SCONJ
cord-018764-02l423mk	320	8	it	it	PRON
cord-018764-02l423mk	320	9	would	would	AUX
cord-018764-02l423mk	320	10	be	be	AUX
cord-018764-02l423mk	320	11	equally	equally	ADV
cord-018764-02l423mk	320	12	plausible	plausible	ADJ
cord-018764-02l423mk	320	13	across	across	ADP
cord-018764-02l423mk	320	14	a	a	DET
cord-018764-02l423mk	320	15	range	range	NOUN
cord-018764-02l423mk	320	16	of	of	ADP
cord-018764-02l423mk	320	17	haemoglobinopathies	haemoglobinopathy	NOUN
cord-018764-02l423mk	320	18	,	,	PUNCT
cord-018764-02l423mk	320	19	including	include	VERB
cord-018764-02l423mk	320	20	hbc	hbc	PROPN
cord-018764-02l423mk	320	21	.	.	PUNCT
cord-018764-02l423mk	321	1	variations	variation	NOUN
cord-018764-02l423mk	321	2	in	in	ADP
cord-018764-02l423mk	321	3	erythrocyte	erythrocyte	NOUN
cord-018764-02l423mk	321	4	membrane	membrane	NOUN
cord-018764-02l423mk	321	5	proteins	protein	NOUN
cord-018764-02l423mk	321	6	also	also	ADV
cord-018764-02l423mk	321	7	have	have	VERB
cord-018764-02l423mk	321	8	a	a	DET
cord-018764-02l423mk	321	9	profound	profound	ADJ
cord-018764-02l423mk	321	10	influence	influence	NOUN
cord-018764-02l423mk	321	11	on	on	ADP
cord-018764-02l423mk	321	12	malaria	malaria	NOUN
cord-018764-02l423mk	321	13	susceptibility	susceptibility	NOUN
cord-018764-02l423mk	321	14	.	.	PUNCT
cord-018764-02l423mk	322	1	most	most	ADJ
cord-018764-02l423mk	322	2	notably	notably	ADV
cord-018764-02l423mk	322	3	the	the	DET
cord-018764-02l423mk	322	4	absence	absence	NOUN
cord-018764-02l423mk	322	5	of	of	ADP
cord-018764-02l423mk	322	6	duffy	duffy	ADJ
cord-018764-02l423mk	322	7	antigen	antigen	PROPN
cord-018764-02l423mk	322	8	protein	protein	NOUN
cord-018764-02l423mk	322	9	confers	confer	VERB
cord-018764-02l423mk	322	10	absolute	absolute	ADJ
cord-018764-02l423mk	322	11	protection	protection	NOUN
cord-018764-02l423mk	322	12	to	to	ADP
cord-018764-02l423mk	322	13	p.	p.	PROPN
cord-018764-02l423mk	322	14	vivax	vivax	PROPN
cord-018764-02l423mk	322	15	infection	infection	NOUN
cord-018764-02l423mk	322	16	.	.	PUNCT
cord-018764-02l423mk	323	1	more	more	ADV
cord-018764-02l423mk	323	2	recently	recently	ADV
cord-018764-02l423mk	323	3	,	,	PUNCT
cord-018764-02l423mk	323	4	the	the	DET
cord-018764-02l423mk	323	5	duffy	duffy	ADJ
cord-018764-02l423mk	323	6	antigen	antigen	PROPN
cord-018764-02l423mk	323	7	has	have	AUX
cord-018764-02l423mk	323	8	also	also	ADV
cord-018764-02l423mk	323	9	been	be	AUX
cord-018764-02l423mk	323	10	associated	associate	VERB
cord-018764-02l423mk	323	11	with	with	ADP
cord-018764-02l423mk	323	12	a	a	DET
cord-018764-02l423mk	323	13	protection	protection	NOUN
cord-018764-02l423mk	323	14	against	against	ADP
cord-018764-02l423mk	323	15	falciparum	falciparum	NOUN
cord-018764-02l423mk	323	16	malaria	malaria	NOUN
cord-018764-02l423mk	323	17	[	[	X
cord-018764-02l423mk	323	18	192	192	NUM
cord-018764-02l423mk	323	19	]	]	PUNCT
cord-018764-02l423mk	323	20	.	.	PUNCT
cord-018764-02l423mk	324	1	enzymes	enzyme	NOUN
cord-018764-02l423mk	324	2	involved	involve	VERB
cord-018764-02l423mk	324	3	with	with	ADP
cord-018764-02l423mk	324	4	iron	iron	NOUN
cord-018764-02l423mk	324	5	handling	handling	NOUN
cord-018764-02l423mk	324	6	may	may	AUX
cord-018764-02l423mk	324	7	also	also	ADV
cord-018764-02l423mk	324	8	have	have	VERB
cord-018764-02l423mk	324	9	a	a	DET
cord-018764-02l423mk	324	10	critical	critical	ADJ
cord-018764-02l423mk	324	11	influence	influence	NOUN
cord-018764-02l423mk	324	12	on	on	ADP
cord-018764-02l423mk	324	13	malaria	malaria	NOUN
cord-018764-02l423mk	324	14	morbidity	morbidity	NOUN
cord-018764-02l423mk	324	15	.	.	PUNCT
cord-018764-02l423mk	325	1	a	a	DET
cord-018764-02l423mk	325	2	recent	recent	ADJ
cord-018764-02l423mk	325	3	study	study	NOUN
cord-018764-02l423mk	325	4	from	from	ADP
cord-018764-02l423mk	325	5	the	the	DET
cord-018764-02l423mk	325	6	gambia	gambia	PROPN
cord-018764-02l423mk	325	7	demonstrated	demonstrate	VERB
cord-018764-02l423mk	325	8	that	that	SCONJ
cord-018764-02l423mk	325	9	children	child	NOUN
cord-018764-02l423mk	325	10	in	in	ADP
cord-018764-02l423mk	325	11	an	an	DET
cord-018764-02l423mk	325	12	endemic	endemic	ADJ
cord-018764-02l423mk	325	13	malaria	malaria	NOUN
cord-018764-02l423mk	325	14	area	area	NOUN
cord-018764-02l423mk	325	15	possessing	possess	VERB
cord-018764-02l423mk	325	16	the	the	DET
cord-018764-02l423mk	325	17	haptoglobin	haptoglobin	NOUN
cord-018764-02l423mk	325	18	2,2	2,2	NUM
cord-018764-02l423mk	325	19	,	,	PUNCT
cord-018764-02l423mk	325	20	isotype	isotype	NOUN
cord-018764-02l423mk	325	21	had	have	VERB
cord-018764-02l423mk	325	22	a	a	DET
cord-018764-02l423mk	325	23	significantly	significantly	ADV
cord-018764-02l423mk	325	24	increased	increase	VERB
cord-018764-02l423mk	325	25	risk	risk	NOUN
cord-018764-02l423mk	325	26	of	of	ADP
cord-018764-02l423mk	325	27	anaemia	anaemia	NOUN
cord-018764-02l423mk	326	1	[	[	PUNCT
cord-018764-02l423mk	326	2	193	193	NUM
cord-018764-02l423mk	326	3	]	]	PUNCT
cord-018764-02l423mk	326	4	.	.	PUNCT
cord-018764-02l423mk	327	1	however	however	ADV
cord-018764-02l423mk	327	2	,	,	PUNCT
cord-018764-02l423mk	327	3	a	a	DET
cord-018764-02l423mk	327	4	lack	lack	NOUN
cord-018764-02l423mk	327	5	of	of	ADP
cord-018764-02l423mk	327	6	parallel	parallel	ADJ
cord-018764-02l423mk	327	7	alterations	alteration	NOUN
cord-018764-02l423mk	327	8	in	in	ADP
cord-018764-02l423mk	327	9	other	other	ADJ
cord-018764-02l423mk	327	10	haematinic	haematinic	ADJ
cord-018764-02l423mk	327	11	indices	index	NOUN
cord-018764-02l423mk	327	12	leaves	leave	VERB
cord-018764-02l423mk	327	13	the	the	DET
cord-018764-02l423mk	327	14	mechanism	mechanism	NOUN
cord-018764-02l423mk	327	15	of	of	ADP
cord-018764-02l423mk	327	16	this	this	DET
cord-018764-02l423mk	327	17	process	process	NOUN
cord-018764-02l423mk	327	18	unclear	unclear	ADJ
cord-018764-02l423mk	327	19	.	.	PUNCT
cord-018764-02l423mk	328	1	malarial	malarial	ADJ
cord-018764-02l423mk	328	2	protection	protection	NOUN
cord-018764-02l423mk	328	3	within	within	ADP
cord-018764-02l423mk	328	4	individuals	individual	NOUN
cord-018764-02l423mk	328	5	exhibiting	exhibit	VERB
cord-018764-02l423mk	328	6	multiple	multiple	ADJ
cord-018764-02l423mk	328	7	rbc	rbc	PROPN
cord-018764-02l423mk	328	8	abnormalities	abnormality	NOUN
cord-018764-02l423mk	328	9	appears	appear	VERB
cord-018764-02l423mk	328	10	even	even	ADV
cord-018764-02l423mk	328	11	more	more	ADV
cord-018764-02l423mk	328	12	complex	complex	ADJ
cord-018764-02l423mk	328	13	.	.	PUNCT
cord-018764-02l423mk	329	1	a	a	DET
cord-018764-02l423mk	329	2	recent	recent	ADJ
cord-018764-02l423mk	329	3	study	study	NOUN
cord-018764-02l423mk	329	4	observed	observe	VERB
cord-018764-02l423mk	329	5	that	that	SCONJ
cord-018764-02l423mk	329	6	the	the	DET
cord-018764-02l423mk	329	7	concurrent	concurrent	ADJ
cord-018764-02l423mk	329	8	presence	presence	NOUN
cord-018764-02l423mk	329	9	of	of	ADP
cord-018764-02l423mk	329	10	sickle	sickle	ADJ
cord-018764-02l423mk	329	11	cell	cell	NOUN
cord-018764-02l423mk	329	12	and	and	CCONJ
cord-018764-02l423mk	329	13	-thalassaemia	-thalassaemia	PROPN
cord-018764-02l423mk	329	14	trait	trait	NOUN
cord-018764-02l423mk	329	15	among	among	ADP
cord-018764-02l423mk	329	16	african	african	ADJ
cord-018764-02l423mk	329	17	children	child	NOUN
cord-018764-02l423mk	329	18	had	have	VERB
cord-018764-02l423mk	329	19	a	a	DET
cord-018764-02l423mk	329	20	negative	negative	ADJ
cord-018764-02l423mk	329	21	influence	influence	NOUN
cord-018764-02l423mk	329	22	on	on	ADP
cord-018764-02l423mk	329	23	the	the	DET
cord-018764-02l423mk	329	24	risk	risk	NOUN
cord-018764-02l423mk	329	25	of	of	ADP
cord-018764-02l423mk	329	26	malaria	malaria	NOUN
cord-018764-02l423mk	329	27	infection	infection	NOUN
cord-018764-02l423mk	329	28	[	[	X
cord-018764-02l423mk	329	29	194	194	NUM
cord-018764-02l423mk	329	30	]	]	PUNCT
cord-018764-02l423mk	329	31	.	.	PUNCT
cord-018764-02l423mk	330	1	the	the	DET
cord-018764-02l423mk	330	2	results	result	NOUN
cord-018764-02l423mk	330	3	warn	warn	VERB
cord-018764-02l423mk	330	4	geneticists	geneticist	NOUN
cord-018764-02l423mk	330	5	that	that	PRON
cord-018764-02l423mk	330	6	gene	gene	NOUN
cord-018764-02l423mk	330	7	epistasis	epistasis	NOUN
cord-018764-02l423mk	330	8	may	may	AUX
cord-018764-02l423mk	330	9	have	have	VERB
cord-018764-02l423mk	330	10	a	a	DET
cord-018764-02l423mk	330	11	profound	profound	ADJ
cord-018764-02l423mk	330	12	influence	influence	NOUN
cord-018764-02l423mk	330	13	on	on	ADP
cord-018764-02l423mk	330	14	overall	overall	ADJ
cord-018764-02l423mk	330	15	malarial	malarial	ADJ
cord-018764-02l423mk	330	16	susceptibility	susceptibility	NOUN
cord-018764-02l423mk	330	17	.	.	PUNCT
cord-018764-02l423mk	331	1	in	in	ADP
cord-018764-02l423mk	331	2	tropical	tropical	ADJ
cord-018764-02l423mk	331	3	countries	country	NOUN
cord-018764-02l423mk	331	4	many	many	ADJ
cord-018764-02l423mk	331	5	hospital	hospital	NOUN
cord-018764-02l423mk	331	6	deaths	death	NOUN
cord-018764-02l423mk	331	7	from	from	ADP
cord-018764-02l423mk	331	8	falciparum	falciparum	NOUN
cord-018764-02l423mk	331	9	malaria	malaria	NOUN
cord-018764-02l423mk	331	10	happen	happen	VERB
cord-018764-02l423mk	331	11	before	before	SCONJ
cord-018764-02l423mk	331	12	anti	anti	ADJ
cord-018764-02l423mk	331	13	-	-	ADJ
cord-018764-02l423mk	331	14	malarial	malarial	ADJ
cord-018764-02l423mk	331	15	drugs	drug	NOUN
cord-018764-02l423mk	331	16	have	have	AUX
cord-018764-02l423mk	331	17	had	have	VERB
cord-018764-02l423mk	331	18	time	time	NOUN
cord-018764-02l423mk	331	19	to	to	PART
cord-018764-02l423mk	331	20	kill	kill	VERB
cord-018764-02l423mk	331	21	the	the	DET
cord-018764-02l423mk	331	22	parasites	parasite	NOUN
cord-018764-02l423mk	331	23	.	.	PUNCT
cord-018764-02l423mk	332	1	two	two	NUM
cord-018764-02l423mk	332	2	approaches	approach	NOUN
cord-018764-02l423mk	332	3	could	could	AUX
cord-018764-02l423mk	332	4	help	help	VERB
cord-018764-02l423mk	332	5	rectify	rectify	VERB
cord-018764-02l423mk	332	6	this	this	DET
cord-018764-02l423mk	332	7	-addressing	-addresse	VERB
cord-018764-02l423mk	332	8	public	public	ADJ
cord-018764-02l423mk	332	9	-	-	PUNCT
cord-018764-02l423mk	332	10	health	health	NOUN
cord-018764-02l423mk	332	11	problems	problem	NOUN
cord-018764-02l423mk	332	12	resulting	result	VERB
cord-018764-02l423mk	332	13	in	in	ADP
cord-018764-02l423mk	332	14	delayed	delay	VERB
cord-018764-02l423mk	332	15	presentation	presentation	NOUN
cord-018764-02l423mk	332	16	,	,	PUNCT
cord-018764-02l423mk	332	17	and	and	CCONJ
cord-018764-02l423mk	332	18	identifying	identify	VERB
cord-018764-02l423mk	332	19	the	the	DET
cord-018764-02l423mk	332	20	physiological	physiological	ADJ
cord-018764-02l423mk	332	21	processes	process	NOUN
cord-018764-02l423mk	332	22	and	and	CCONJ
cord-018764-02l423mk	332	23	molecular	molecular	ADJ
cord-018764-02l423mk	332	24	pathways	pathway	NOUN
cord-018764-02l423mk	332	25	that	that	PRON
cord-018764-02l423mk	332	26	lead	lead	VERB
cord-018764-02l423mk	332	27	to	to	ADP
cord-018764-02l423mk	332	28	these	these	DET
cord-018764-02l423mk	332	29	early	early	ADJ
cord-018764-02l423mk	332	30	deaths	death	NOUN
cord-018764-02l423mk	332	31	,	,	PUNCT
cord-018764-02l423mk	332	32	with	with	ADP
cord-018764-02l423mk	332	33	a	a	DET
cord-018764-02l423mk	332	34	view	view	NOUN
cord-018764-02l423mk	332	35	to	to	ADP
cord-018764-02l423mk	332	36	developing	develop	VERB
cord-018764-02l423mk	332	37	evidence	evidence	NOUN
cord-018764-02l423mk	332	38	-	-	PUNCT
cord-018764-02l423mk	332	39	based	base	VERB
cord-018764-02l423mk	332	40	adjunct	adjunct	ADJ
cord-018764-02l423mk	332	41	therapies	therapy	NOUN
cord-018764-02l423mk	332	42	.	.	PUNCT
cord-018764-02l423mk	333	1	therapies	therapy	NOUN
cord-018764-02l423mk	333	2	being	be	AUX
cord-018764-02l423mk	333	3	explored	explore	VERB
cord-018764-02l423mk	333	4	in	in	ADP
cord-018764-02l423mk	333	5	sepsis	sepsis	NOUN
cord-018764-02l423mk	333	6	,	,	PUNCT
cord-018764-02l423mk	333	7	and	and	CCONJ
cord-018764-02l423mk	333	8	based	base	VERB
cord-018764-02l423mk	333	9	on	on	ADP
cord-018764-02l423mk	333	10	disease	disease	PROPN
cord-018764-02l423mk	333	11	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	333	12	data	datum	NOUN
cord-018764-02l423mk	333	13	common	common	ADJ
cord-018764-02l423mk	333	14	to	to	ADP
cord-018764-02l423mk	333	15	sepsis	sepsis	NOUN
cord-018764-02l423mk	333	16	and	and	CCONJ
cord-018764-02l423mk	333	17	malaria	malaria	NOUN
cord-018764-02l423mk	333	18	,	,	PUNCT
cord-018764-02l423mk	333	19	may	may	AUX
cord-018764-02l423mk	333	20	prove	prove	VERB
cord-018764-02l423mk	333	21	to	to	PART
cord-018764-02l423mk	333	22	be	be	AUX
cord-018764-02l423mk	333	23	transferable	transferable	ADJ
cord-018764-02l423mk	333	24	from	from	ADP
cord-018764-02l423mk	333	25	either	either	PRON
cord-018764-02l423mk	333	26	of	of	ADP
cord-018764-02l423mk	333	27	these	these	DET
cord-018764-02l423mk	333	28	diseases	disease	NOUN
cord-018764-02l423mk	333	29	to	to	ADP
cord-018764-02l423mk	333	30	the	the	DET
cord-018764-02l423mk	333	31	other	other	ADJ
cord-018764-02l423mk	333	32	.	.	PUNCT
cord-018764-02l423mk	334	1	as	as	SCONJ
cord-018764-02l423mk	334	2	noted	note	VERB
cord-018764-02l423mk	334	3	above	above	ADP
cord-018764-02l423mk	334	4	,	,	PUNCT
cord-018764-02l423mk	334	5	circulating	circulate	VERB
cord-018764-02l423mk	334	6	levels	level	NOUN
cord-018764-02l423mk	334	7	of	of	ADP
cord-018764-02l423mk	334	8	a	a	DET
cord-018764-02l423mk	334	9	late	late	ADV
cord-018764-02l423mk	334	10	-	-	PUNCT
cord-018764-02l423mk	334	11	appearing	appear	VERB
cord-018764-02l423mk	334	12	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	334	13	cytokine	cytokine	NOUN
cord-018764-02l423mk	334	14	,	,	PUNCT
cord-018764-02l423mk	334	15	hmgb1	hmgb1	PROPN
cord-018764-02l423mk	334	16	,	,	PUNCT
cord-018764-02l423mk	334	17	are	be	AUX
cord-018764-02l423mk	334	18	increased	increase	VERB
cord-018764-02l423mk	334	19	in	in	ADP
cord-018764-02l423mk	334	20	falciparum	falciparum	NOUN
cord-018764-02l423mk	334	21	malaria	malaria	NOUN
cord-018764-02l423mk	334	22	[	[	X
cord-018764-02l423mk	334	23	41	41	NUM
cord-018764-02l423mk	334	24	]	]	PUNCT
cord-018764-02l423mk	334	25	as	as	ADV
cord-018764-02l423mk	334	26	well	well	ADV
cord-018764-02l423mk	334	27	as	as	ADP
cord-018764-02l423mk	334	28	in	in	ADP
cord-018764-02l423mk	334	29	sepsis	sepsis	NOUN
cord-018764-02l423mk	334	30	.	.	PUNCT
cord-018764-02l423mk	335	1	results	result	NOUN
cord-018764-02l423mk	335	2	from	from	ADP
cord-018764-02l423mk	335	3	animal	animal	NOUN
cord-018764-02l423mk	335	4	models	model	NOUN
cord-018764-02l423mk	335	5	on	on	ADP
cord-018764-02l423mk	335	6	the	the	DET
cord-018764-02l423mk	335	7	role	role	NOUN
cord-018764-02l423mk	335	8	of	of	ADP
cord-018764-02l423mk	335	9	hmgb1	hmgb1	PROPN
cord-018764-02l423mk	335	10	,	,	PUNCT
cord-018764-02l423mk	335	11	although	although	SCONJ
cord-018764-02l423mk	335	12	untested	unteste	VERB
cord-018764-02l423mk	335	13	in	in	ADP
cord-018764-02l423mk	335	14	humans	human	NOUN
cord-018764-02l423mk	335	15	,	,	PUNCT
cord-018764-02l423mk	335	16	have	have	AUX
cord-018764-02l423mk	335	17	inspired	inspire	VERB
cord-018764-02l423mk	335	18	enthusiasm	enthusiasm	NOUN
cord-018764-02l423mk	335	19	for	for	ADP
cord-018764-02l423mk	335	20	inhibition	inhibition	NOUN
cord-018764-02l423mk	335	21	of	of	ADP
cord-018764-02l423mk	335	22	this	this	DET
cord-018764-02l423mk	335	23	molecule	molecule	NOUN
cord-018764-02l423mk	335	24	as	as	ADP
cord-018764-02l423mk	335	25	a	a	DET
cord-018764-02l423mk	335	26	potential	potential	ADJ
cord-018764-02l423mk	335	27	intervention	intervention	NOUN
cord-018764-02l423mk	335	28	for	for	ADP
cord-018764-02l423mk	335	29	human	human	ADJ
cord-018764-02l423mk	335	30	sepsis	sepsis	NOUN
cord-018764-02l423mk	335	31	.	.	PUNCT
cord-018764-02l423mk	336	1	for	for	ADP
cord-018764-02l423mk	336	2	instance	instance	NOUN
cord-018764-02l423mk	336	3	,	,	PUNCT
cord-018764-02l423mk	336	4	anti	anti	ADJ
cord-018764-02l423mk	336	5	-	-	ADJ
cord-018764-02l423mk	336	6	hmgb1	hmgb1	ADJ
cord-018764-02l423mk	336	7	antibodies	antibody	NOUN
cord-018764-02l423mk	336	8	provided	provide	VERB
cord-018764-02l423mk	336	9	dose	dose	NOUN
cord-018764-02l423mk	336	10	-	-	PUNCT
cord-018764-02l423mk	336	11	dependent	dependent	ADJ
cord-018764-02l423mk	336	12	protection	protection	NOUN
cord-018764-02l423mk	336	13	[	[	X
cord-018764-02l423mk	336	14	37	37	NUM
cord-018764-02l423mk	336	15	]	]	PUNCT
cord-018764-02l423mk	336	16	and	and	CCONJ
cord-018764-02l423mk	336	17	reduced	reduce	VERB
cord-018764-02l423mk	336	18	mortality	mortality	NOUN
cord-018764-02l423mk	336	19	[	[	PUNCT
cord-018764-02l423mk	336	20	195	195	NUM
cord-018764-02l423mk	336	21	]	]	PUNCT
cord-018764-02l423mk	336	22	against	against	ADP
cord-018764-02l423mk	336	23	experimental	experimental	ADJ
cord-018764-02l423mk	336	24	sepsis	sepsis	NOUN
cord-018764-02l423mk	336	25	in	in	ADP
cord-018764-02l423mk	336	26	mice	mouse	NOUN
cord-018764-02l423mk	336	27	.	.	PUNCT
cord-018764-02l423mk	337	1	late	late	ADJ
cord-018764-02l423mk	337	2	administration	administration	PROPN
cord-018764-02l423mk	337	3	of	of	ADP
cord-018764-02l423mk	337	4	ethyl	ethyl	PROPN
cord-018764-02l423mk	337	5	pyruvate	pyruvate	PROPN
cord-018764-02l423mk	337	6	,	,	PUNCT
cord-018764-02l423mk	337	7	which	which	PRON
cord-018764-02l423mk	337	8	inhibits	inhibit	VERB
cord-018764-02l423mk	337	9	hmgb1	hmgb1	NUM
cord-018764-02l423mk	337	10	release	release	NOUN
cord-018764-02l423mk	337	11	from	from	ADP
cord-018764-02l423mk	337	12	macrophages	macrophage	NOUN
cord-018764-02l423mk	337	13	,	,	PUNCT
cord-018764-02l423mk	337	14	also	also	ADV
cord-018764-02l423mk	337	15	conferred	confer	VERB
cord-018764-02l423mk	337	16	protection	protection	NOUN
cord-018764-02l423mk	337	17	against	against	ADP
cord-018764-02l423mk	337	18	endotoxaemia	endotoxaemia	NOUN
cord-018764-02l423mk	337	19	in	in	ADP
cord-018764-02l423mk	337	20	mice	mouse	NOUN
cord-018764-02l423mk	337	21	[	[	PUNCT
cord-018764-02l423mk	337	22	196	196	NUM
cord-018764-02l423mk	337	23	]	]	PUNCT
cord-018764-02l423mk	337	24	.	.	PUNCT
cord-018764-02l423mk	338	1	treatments	treatment	NOUN
cord-018764-02l423mk	338	2	directed	direct	VERB
cord-018764-02l423mk	338	3	towards	towards	ADP
cord-018764-02l423mk	338	4	critical	critical	ADJ
cord-018764-02l423mk	338	5	downstream	downstream	ADJ
cord-018764-02l423mk	338	6	consequences	consequence	NOUN
cord-018764-02l423mk	338	7	of	of	ADP
cord-018764-02l423mk	338	8	malaria	malaria	NOUN
cord-018764-02l423mk	338	9	infection	infection	NOUN
cord-018764-02l423mk	338	10	and	and	CCONJ
cord-018764-02l423mk	338	11	inflammation	inflammation	NOUN
cord-018764-02l423mk	338	12	,	,	PUNCT
cord-018764-02l423mk	338	13	such	such	ADJ
cord-018764-02l423mk	338	14	as	as	ADP
cord-018764-02l423mk	338	15	those	those	PRON
cord-018764-02l423mk	338	16	intended	intend	VERB
cord-018764-02l423mk	338	17	to	to	PART
cord-018764-02l423mk	338	18	limit	limit	VERB
cord-018764-02l423mk	338	19	acidosis	acidosis	NOUN
cord-018764-02l423mk	338	20	,	,	PUNCT
cord-018764-02l423mk	338	21	are	be	AUX
cord-018764-02l423mk	338	22	also	also	ADV
cord-018764-02l423mk	338	23	a	a	DET
cord-018764-02l423mk	338	24	focus	focus	NOUN
cord-018764-02l423mk	338	25	of	of	ADP
cord-018764-02l423mk	338	26	investigation	investigation	NOUN
cord-018764-02l423mk	338	27	.	.	PUNCT
cord-018764-02l423mk	339	1	one	one	NUM
cord-018764-02l423mk	339	2	current	current	ADJ
cord-018764-02l423mk	339	3	approach	approach	NOUN
cord-018764-02l423mk	339	4	is	be	AUX
cord-018764-02l423mk	339	5	to	to	PART
cord-018764-02l423mk	339	6	identify	identify	VERB
cord-018764-02l423mk	339	7	which	which	DET
cord-018764-02l423mk	339	8	acute	acute	ADJ
cord-018764-02l423mk	339	9	malaria	malaria	NOUN
cord-018764-02l423mk	339	10	patients	patient	NOUN
cord-018764-02l423mk	339	11	most	most	ADV
cord-018764-02l423mk	339	12	benefit	benefit	VERB
cord-018764-02l423mk	339	13	from	from	ADP
cord-018764-02l423mk	339	14	early	early	ADJ
cord-018764-02l423mk	339	15	volume	volume	NOUN
cord-018764-02l423mk	339	16	expansion	expansion	NOUN
cord-018764-02l423mk	339	17	[	[	PUNCT
cord-018764-02l423mk	339	18	197	197	NUM
cord-018764-02l423mk	339	19	]	]	PUNCT
cord-018764-02l423mk	339	20	.	.	PUNCT
cord-018764-02l423mk	340	1	controlling	control	VERB
cord-018764-02l423mk	340	2	lactic	lactic	ADJ
cord-018764-02l423mk	340	3	acidosis	acidosis	NOUN
cord-018764-02l423mk	340	4	via	via	ADP
cord-018764-02l423mk	340	5	sodium	sodium	NOUN
cord-018764-02l423mk	340	6	dichloroacetate	dichloroacetate	PROPN
cord-018764-02l423mk	340	7	(	(	PUNCT
cord-018764-02l423mk	340	8	dca	dca	PROPN
cord-018764-02l423mk	340	9	)	)	PUNCT
cord-018764-02l423mk	340	10	,	,	PUNCT
cord-018764-02l423mk	340	11	an	an	DET
cord-018764-02l423mk	340	12	inhibitor	inhibitor	NOUN
cord-018764-02l423mk	340	13	of	of	ADP
cord-018764-02l423mk	340	14	pyruvate	pyruvate	PROPN
cord-018764-02l423mk	340	15	dehydrogenate	dehydrogenate	PROPN
cord-018764-02l423mk	340	16	kinase	kinase	PROPN
cord-018764-02l423mk	340	17	(	(	PUNCT
cord-018764-02l423mk	340	18	maintaining	maintain	VERB
cord-018764-02l423mk	340	19	pyruvate	pyruvate	ADJ
cord-018764-02l423mk	340	20	dehydrogenase	dehydrogenase	NOUN
cord-018764-02l423mk	340	21	in	in	ADP
cord-018764-02l423mk	340	22	its	its	PRON
cord-018764-02l423mk	340	23	active	active	ADJ
cord-018764-02l423mk	340	24	form	form	NOUN
cord-018764-02l423mk	340	25	)	)	PUNCT
cord-018764-02l423mk	340	26	,	,	PUNCT
cord-018764-02l423mk	340	27	is	be	AUX
cord-018764-02l423mk	340	28	also	also	ADV
cord-018764-02l423mk	340	29	being	be	AUX
cord-018764-02l423mk	340	30	examined	examine	VERB
cord-018764-02l423mk	340	31	.	.	PUNCT
cord-018764-02l423mk	341	1	dca	dca	PROPN
cord-018764-02l423mk	341	2	reduced	reduce	VERB
cord-018764-02l423mk	341	3	lactate	lactate	NOUN
cord-018764-02l423mk	341	4	levels	level	NOUN
cord-018764-02l423mk	341	5	in	in	ADP
cord-018764-02l423mk	341	6	acute	acute	ADJ
cord-018764-02l423mk	341	7	malaria	malaria	NOUN
cord-018764-02l423mk	341	8	patients	patient	NOUN
cord-018764-02l423mk	341	9	[	[	X
cord-018764-02l423mk	341	10	198	198	NUM
cord-018764-02l423mk	341	11	]	]	PUNCT
cord-018764-02l423mk	341	12	,	,	PUNCT
cord-018764-02l423mk	341	13	although	although	SCONJ
cord-018764-02l423mk	341	14	the	the	DET
cord-018764-02l423mk	341	15	study	study	NOUN
cord-018764-02l423mk	341	16	was	be	AUX
cord-018764-02l423mk	341	17	unable	unable	ADJ
cord-018764-02l423mk	341	18	to	to	PART
cord-018764-02l423mk	341	19	determine	determine	VERB
cord-018764-02l423mk	341	20	whether	whether	SCONJ
cord-018764-02l423mk	341	21	treatment	treatment	NOUN
cord-018764-02l423mk	341	22	improved	improve	VERB
cord-018764-02l423mk	341	23	outcome	outcome	NOUN
cord-018764-02l423mk	341	24	.	.	PUNCT
cord-018764-02l423mk	342	1	an	an	DET
cord-018764-02l423mk	342	2	earlier	early	ADV
cord-018764-02l423mk	342	3	large	large	ADJ
cord-018764-02l423mk	342	4	sepsis	sepsis	NOUN
cord-018764-02l423mk	342	5	study	study	NOUN
cord-018764-02l423mk	342	6	also	also	ADV
cord-018764-02l423mk	342	7	demonstrated	demonstrate	VERB
cord-018764-02l423mk	342	8	that	that	SCONJ
cord-018764-02l423mk	342	9	dca	dca	PROPN
cord-018764-02l423mk	342	10	reduced	reduce	VERB
cord-018764-02l423mk	342	11	lactate	lactate	NOUN
cord-018764-02l423mk	342	12	,	,	PUNCT
cord-018764-02l423mk	342	13	but	but	CCONJ
cord-018764-02l423mk	342	14	again	again	ADV
cord-018764-02l423mk	342	15	with	with	ADP
cord-018764-02l423mk	342	16	no	no	DET
cord-018764-02l423mk	342	17	improvement	improvement	NOUN
cord-018764-02l423mk	342	18	in	in	ADP
cord-018764-02l423mk	342	19	outcome	outcome	NOUN
cord-018764-02l423mk	342	20	[	[	X
cord-018764-02l423mk	342	21	126	126	NUM
cord-018764-02l423mk	342	22	]	]	PUNCT
cord-018764-02l423mk	342	23	.	.	PUNCT
cord-018764-02l423mk	343	1	as	as	SCONJ
cord-018764-02l423mk	343	2	outlined	outline	VERB
cord-018764-02l423mk	343	3	in	in	ADP
cord-018764-02l423mk	343	4	the	the	DET
cord-018764-02l423mk	343	5	section	section	NOUN
cord-018764-02l423mk	343	6	'	'	PUNCT
cord-018764-02l423mk	343	7	is	be	AUX
cord-018764-02l423mk	343	8	hyperlactataemia	hyperlactataemia	NOUN
cord-018764-02l423mk	343	9	a	a	DET
cord-018764-02l423mk	343	10	cause	cause	NOUN
cord-018764-02l423mk	343	11	or	or	CCONJ
cord-018764-02l423mk	343	12	marker	marker	NOUN
cord-018764-02l423mk	343	13	of	of	ADP
cord-018764-02l423mk	343	14	the	the	DET
cord-018764-02l423mk	343	15	acidosis	acidosis	NOUN
cord-018764-02l423mk	343	16	of	of	ADP
cord-018764-02l423mk	343	17	malaria	malaria	NOUN
cord-018764-02l423mk	343	18	?	?	PUNCT
cord-018764-02l423mk	343	19	'	'	PUNCT
cord-018764-02l423mk	343	20	,	,	PUNCT
cord-018764-02l423mk	343	21	some	some	DET
cord-018764-02l423mk	343	22	researchers	researcher	NOUN
cord-018764-02l423mk	343	23	argue	argue	VERB
cord-018764-02l423mk	343	24	,	,	PUNCT
cord-018764-02l423mk	343	25	in	in	ADP
cord-018764-02l423mk	343	26	view	view	NOUN
cord-018764-02l423mk	343	27	of	of	ADP
cord-018764-02l423mk	343	28	the	the	DET
cord-018764-02l423mk	343	29	strong	strong	ADJ
cord-018764-02l423mk	343	30	ion	ion	NOUN
cord-018764-02l423mk	343	31	difference	difference	NOUN
cord-018764-02l423mk	343	32	contributing	contribute	VERB
cord-018764-02l423mk	343	33	to	to	ADP
cord-018764-02l423mk	343	34	acidosis	acidosis	NOUN
cord-018764-02l423mk	343	35	and	and	CCONJ
cord-018764-02l423mk	343	36	the	the	DET
cord-018764-02l423mk	343	37	postulated	postulate	VERB
cord-018764-02l423mk	343	38	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	343	39	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	343	40	during	during	ADP
cord-018764-02l423mk	343	41	acute	acute	ADJ
cord-018764-02l423mk	343	42	malaria	malaria	NOUN
cord-018764-02l423mk	343	43	infection	infection	NOUN
cord-018764-02l423mk	343	44	,	,	PUNCT
cord-018764-02l423mk	343	45	that	that	DET
cord-018764-02l423mk	343	46	lactate	lactate	NOUN
cord-018764-02l423mk	343	47	reduction	reduction	NOUN
cord-018764-02l423mk	343	48	per	per	X
cord-018764-02l423mk	343	49	se	se	X
cord-018764-02l423mk	343	50	may	may	AUX
cord-018764-02l423mk	343	51	have	have	VERB
cord-018764-02l423mk	343	52	limited	limited	ADJ
cord-018764-02l423mk	343	53	impact	impact	NOUN
cord-018764-02l423mk	343	54	on	on	ADP
cord-018764-02l423mk	343	55	prognosis	prognosis	NOUN
cord-018764-02l423mk	343	56	.	.	PUNCT
cord-018764-02l423mk	344	1	other	other	ADJ
cord-018764-02l423mk	344	2	adjunct	adjunct	ADJ
cord-018764-02l423mk	344	3	therapies	therapy	NOUN
cord-018764-02l423mk	344	4	are	be	AUX
cord-018764-02l423mk	344	5	also	also	ADV
cord-018764-02l423mk	344	6	being	be	AUX
cord-018764-02l423mk	344	7	examined	examine	VERB
cord-018764-02l423mk	344	8	.	.	PUNCT
cord-018764-02l423mk	345	1	improving	improve	VERB
cord-018764-02l423mk	345	2	rbc	rbc	PROPN
cord-018764-02l423mk	345	3	deformability	deformability	PROPN
cord-018764-02l423mk	345	4	provides	provide	VERB
cord-018764-02l423mk	345	5	one	one	NUM
cord-018764-02l423mk	345	6	potential	potential	ADJ
cord-018764-02l423mk	345	7	therapeutic	therapeutic	ADJ
cord-018764-02l423mk	345	8	approach	approach	NOUN
cord-018764-02l423mk	345	9	.	.	PUNCT
cord-018764-02l423mk	346	1	in	in	ADP
cord-018764-02l423mk	346	2	vitro	vitro	X
cord-018764-02l423mk	346	3	studies	study	NOUN
cord-018764-02l423mk	346	4	with	with	ADP
cord-018764-02l423mk	346	5	n	n	NOUN
cord-018764-02l423mk	346	6	-	-	NOUN
cord-018764-02l423mk	346	7	acetylcysteine	acetylcysteine	NOUN
cord-018764-02l423mk	346	8	(	(	PUNCT
cord-018764-02l423mk	346	9	nac	nac	PROPN
cord-018764-02l423mk	346	10	)	)	PUNCT
cord-018764-02l423mk	346	11	,	,	PUNCT
cord-018764-02l423mk	346	12	reported	report	VERB
cord-018764-02l423mk	346	13	to	to	PART
cord-018764-02l423mk	346	14	scavenge	scavenge	VERB
cord-018764-02l423mk	346	15	free	free	ADJ
cord-018764-02l423mk	346	16	radicals	radical	NOUN
cord-018764-02l423mk	346	17	,	,	PUNCT
cord-018764-02l423mk	346	18	showed	show	VERB
cord-018764-02l423mk	346	19	improvement	improvement	NOUN
cord-018764-02l423mk	346	20	in	in	ADP
cord-018764-02l423mk	346	21	red	red	ADJ
cord-018764-02l423mk	346	22	cell	cell	NOUN
cord-018764-02l423mk	346	23	deformability	deformability	NOUN
cord-018764-02l423mk	346	24	through	through	ADP
cord-018764-02l423mk	346	25	in	in	X
cord-018764-02l423mk	346	26	vitro	vitro	X
cord-018764-02l423mk	346	27	studies	study	NOUN
cord-018764-02l423mk	346	28	[	[	PUNCT
cord-018764-02l423mk	346	29	199	199	NUM
cord-018764-02l423mk	346	30	]	]	PUNCT
cord-018764-02l423mk	346	31	.	.	PUNCT
cord-018764-02l423mk	347	1	unfortunately	unfortunately	ADV
cord-018764-02l423mk	347	2	,	,	PUNCT
cord-018764-02l423mk	347	3	an	an	DET
cord-018764-02l423mk	347	4	initial	initial	NOUN
cord-018764-02l423mk	347	5	in	in	ADP
cord-018764-02l423mk	347	6	vivo	vivo	ADJ
cord-018764-02l423mk	347	7	trial	trial	NOUN
cord-018764-02l423mk	347	8	of	of	ADP
cord-018764-02l423mk	347	9	nac	nac	PROPN
cord-018764-02l423mk	347	10	in	in	ADP
cord-018764-02l423mk	347	11	malaria	malaria	NOUN
cord-018764-02l423mk	347	12	patients	patient	NOUN
cord-018764-02l423mk	347	13	had	have	VERB
cord-018764-02l423mk	347	14	no	no	DET
cord-018764-02l423mk	347	15	effect	effect	NOUN
cord-018764-02l423mk	347	16	on	on	ADP
cord-018764-02l423mk	347	17	mortality	mortality	NOUN
cord-018764-02l423mk	347	18	[	[	PUNCT
cord-018764-02l423mk	347	19	200	200	NUM
cord-018764-02l423mk	347	20	]	]	PUNCT
cord-018764-02l423mk	347	21	.	.	PUNCT
cord-018764-02l423mk	348	1	blocking	block	VERB
cord-018764-02l423mk	348	2	endothelial	endothelial	ADJ
cord-018764-02l423mk	348	3	activation	activation	NOUN
cord-018764-02l423mk	348	4	is	be	AUX
cord-018764-02l423mk	348	5	also	also	ADV
cord-018764-02l423mk	348	6	a	a	DET
cord-018764-02l423mk	348	7	focus	focus	NOUN
cord-018764-02l423mk	348	8	of	of	ADP
cord-018764-02l423mk	348	9	research	research	NOUN
cord-018764-02l423mk	348	10	,	,	PUNCT
cord-018764-02l423mk	348	11	with	with	ADP
cord-018764-02l423mk	348	12	initial	initial	ADJ
cord-018764-02l423mk	348	13	in	in	X
cord-018764-02l423mk	348	14	vitro	vitro	X
cord-018764-02l423mk	348	15	studies	study	NOUN
cord-018764-02l423mk	348	16	providing	provide	VERB
cord-018764-02l423mk	348	17	some	some	DET
cord-018764-02l423mk	348	18	encouraging	encouraging	ADJ
cord-018764-02l423mk	348	19	results	result	NOUN
cord-018764-02l423mk	348	20	[	[	X
cord-018764-02l423mk	348	21	201	201	NUM
cord-018764-02l423mk	348	22	]	]	PUNCT
cord-018764-02l423mk	348	23	.	.	PUNCT
cord-018764-02l423mk	349	1	in	in	ADP
cord-018764-02l423mk	349	2	conclusion	conclusion	NOUN
cord-018764-02l423mk	349	3	,	,	PUNCT
cord-018764-02l423mk	349	4	continuing	continue	VERB
cord-018764-02l423mk	349	5	to	to	PART
cord-018764-02l423mk	349	6	identify	identify	VERB
cord-018764-02l423mk	349	7	the	the	DET
cord-018764-02l423mk	349	8	host	host	NOUN
cord-018764-02l423mk	349	9	responses	response	NOUN
cord-018764-02l423mk	349	10	to	to	ADP
cord-018764-02l423mk	349	11	malaria	malaria	NOUN
cord-018764-02l423mk	349	12	infection	infection	NOUN
cord-018764-02l423mk	349	13	that	that	PRON
cord-018764-02l423mk	349	14	lead	lead	VERB
cord-018764-02l423mk	349	15	to	to	ADP
cord-018764-02l423mk	349	16	disease	disease	NOUN
cord-018764-02l423mk	349	17	is	be	AUX
cord-018764-02l423mk	349	18	providing	provide	VERB
cord-018764-02l423mk	349	19	insights	insight	NOUN
cord-018764-02l423mk	349	20	into	into	ADP
cord-018764-02l423mk	349	21	novel	novel	ADJ
cord-018764-02l423mk	349	22	molecular	molecular	ADJ
cord-018764-02l423mk	349	23	mechanisms	mechanism	NOUN
cord-018764-02l423mk	349	24	.	.	PUNCT
cord-018764-02l423mk	350	1	this	this	DET
cord-018764-02l423mk	350	2	information	information	NOUN
cord-018764-02l423mk	350	3	is	be	AUX
cord-018764-02l423mk	350	4	beginning	begin	VERB
cord-018764-02l423mk	350	5	to	to	PART
cord-018764-02l423mk	350	6	guide	guide	VERB
cord-018764-02l423mk	350	7	the	the	DET
cord-018764-02l423mk	350	8	design	design	NOUN
cord-018764-02l423mk	350	9	of	of	ADP
cord-018764-02l423mk	350	10	much	much	ADV
cord-018764-02l423mk	350	11	needed	need	VERB
cord-018764-02l423mk	350	12	additional	additional	ADJ
cord-018764-02l423mk	350	13	therapies	therapy	NOUN
cord-018764-02l423mk	350	14	against	against	ADP
cord-018764-02l423mk	350	15	this	this	DET
cord-018764-02l423mk	350	16	disease	disease	NOUN
cord-018764-02l423mk	350	17	.	.	PUNCT
cord-018764-02l423mk	351	1	there	there	PRON
cord-018764-02l423mk	351	2	is	be	VERB
cord-018764-02l423mk	351	3	little	little	ADJ
cord-018764-02l423mk	351	4	doubt	doubt	NOUN
cord-018764-02l423mk	351	5	that	that	SCONJ
cord-018764-02l423mk	351	6	poor	poor	ADJ
cord-018764-02l423mk	351	7	oxygen	oxygen	NOUN
cord-018764-02l423mk	351	8	supply	supply	NOUN
cord-018764-02l423mk	351	9	through	through	ADP
cord-018764-02l423mk	351	10	vascular	vascular	ADJ
cord-018764-02l423mk	351	11	occlusion	occlusion	NOUN
cord-018764-02l423mk	351	12	or	or	CCONJ
cord-018764-02l423mk	351	13	anaemia	anaemia	NOUN
cord-018764-02l423mk	351	14	could	could	AUX
cord-018764-02l423mk	351	15	contribute	contribute	VERB
cord-018764-02l423mk	351	16	to	to	ADP
cord-018764-02l423mk	351	17	the	the	DET
cord-018764-02l423mk	351	18	body	body	NOUN
cord-018764-02l423mk	351	19	relying	rely	VERB
cord-018764-02l423mk	351	20	on	on	ADP
cord-018764-02l423mk	351	21	excessive	excessive	ADJ
cord-018764-02l423mk	351	22	glycolysis	glycolysis	NOUN
cord-018764-02l423mk	351	23	to	to	PART
cord-018764-02l423mk	351	24	generate	generate	VERB
cord-018764-02l423mk	351	25	energy	energy	NOUN
cord-018764-02l423mk	351	26	,	,	PUNCT
cord-018764-02l423mk	351	27	resulting	result	VERB
cord-018764-02l423mk	351	28	in	in	ADP
cord-018764-02l423mk	351	29	hyperlactataemia	hyperlactataemia	PROPN
cord-018764-02l423mk	351	30	,	,	PUNCT
cord-018764-02l423mk	351	31	hypoglycaemia	hypoglycaemia	NOUN
cord-018764-02l423mk	351	32	,	,	PUNCT
cord-018764-02l423mk	351	33	and	and	CCONJ
cord-018764-02l423mk	351	34	metabolic	metabolic	ADJ
cord-018764-02l423mk	351	35	acidosis	acidosis	NOUN
cord-018764-02l423mk	351	36	,	,	PUNCT
cord-018764-02l423mk	351	37	and	and	CCONJ
cord-018764-02l423mk	351	38	altered	alter	VERB
cord-018764-02l423mk	351	39	consciousness	consciousness	NOUN
cord-018764-02l423mk	351	40	.	.	PUNCT
cord-018764-02l423mk	352	1	however	however	ADV
cord-018764-02l423mk	352	2	,	,	PUNCT
cord-018764-02l423mk	352	3	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	352	4	cytokines	cytokine	NOUN
cord-018764-02l423mk	352	5	control	control	VERB
cord-018764-02l423mk	352	6	these	these	DET
cord-018764-02l423mk	352	7	changes	change	NOUN
cord-018764-02l423mk	352	8	,	,	PUNCT
cord-018764-02l423mk	352	9	as	as	ADV
cord-018764-02l423mk	352	10	well	well	ADV
cord-018764-02l423mk	352	11	as	as	ADP
cord-018764-02l423mk	352	12	inhibit	inhibit	VERB
cord-018764-02l423mk	352	13	the	the	DET
cord-018764-02l423mk	352	14	capacity	capacity	NOUN
cord-018764-02l423mk	352	15	of	of	ADP
cord-018764-02l423mk	352	16	mitochondria	mitochondria	NOUN
cord-018764-02l423mk	352	17	to	to	PART
cord-018764-02l423mk	352	18	use	use	VERB
cord-018764-02l423mk	352	19	oxygen	oxygen	NOUN
cord-018764-02l423mk	352	20	.	.	PUNCT
cord-018764-02l423mk	353	1	thus	thus	ADV
cord-018764-02l423mk	353	2	,	,	PUNCT
cord-018764-02l423mk	353	3	as	as	SCONJ
cord-018764-02l423mk	353	4	described	describe	VERB
cord-018764-02l423mk	353	5	throughout	throughout	ADP
cord-018764-02l423mk	353	6	this	this	DET
cord-018764-02l423mk	353	7	review	review	NOUN
cord-018764-02l423mk	353	8	,	,	PUNCT
cord-018764-02l423mk	353	9	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	353	10	cytokines	cytokine	NOUN
cord-018764-02l423mk	353	11	are	be	AUX
cord-018764-02l423mk	353	12	likely	likely	ADJ
cord-018764-02l423mk	353	13	to	to	PART
cord-018764-02l423mk	353	14	have	have	VERB
cord-018764-02l423mk	353	15	various	various	ADJ
cord-018764-02l423mk	353	16	pivotal	pivotal	ADJ
cord-018764-02l423mk	353	17	roles	role	NOUN
cord-018764-02l423mk	353	18	across	across	ADP
cord-018764-02l423mk	353	19	the	the	DET
cord-018764-02l423mk	353	20	multiple	multiple	ADJ
cord-018764-02l423mk	353	21	pathological	pathological	ADJ
cord-018764-02l423mk	353	22	processes	process	NOUN
cord-018764-02l423mk	353	23	involved	involve	VERB
cord-018764-02l423mk	353	24	in	in	ADP
cord-018764-02l423mk	353	25	malarial	malarial	ADJ
cord-018764-02l423mk	353	26	disease	disease	NOUN
cord-018764-02l423mk	353	27	(	(	PUNCT
cord-018764-02l423mk	353	28	fig	fig	NOUN
cord-018764-02l423mk	353	29	.	.	PROPN
cord-018764-02l423mk	353	30	1	1	NUM
cord-018764-02l423mk	353	31	)	)	PUNCT
cord-018764-02l423mk	353	32	.	.	PUNCT
cord-018764-02l423mk	354	1	indicators	indicator	NOUN
cord-018764-02l423mk	354	2	of	of	ADP
cord-018764-02l423mk	354	3	life	life	NOUN
cord-018764-02l423mk	354	4	-	-	PUNCT
cord-018764-02l423mk	354	5	threatening	threaten	VERB
cord-018764-02l423mk	354	6	malaria	malaria	NOUN
cord-018764-02l423mk	354	7	in	in	ADP
cord-018764-02l423mk	354	8	african	african	ADJ
cord-018764-02l423mk	354	9	children	child	NOUN
cord-018764-02l423mk	354	10	the	the	DET
cord-018764-02l423mk	354	11	pathophysiologic	pathophysiologic	ADJ
cord-018764-02l423mk	354	12	and	and	CCONJ
cord-018764-02l423mk	354	13	prognostic	prognostic	ADJ
cord-018764-02l423mk	354	14	significance	significance	NOUN
cord-018764-02l423mk	354	15	of	of	ADP
cord-018764-02l423mk	354	16	acidosis	acidosis	NOUN
cord-018764-02l423mk	354	17	in	in	ADP
cord-018764-02l423mk	354	18	severe	severe	ADJ
cord-018764-02l423mk	354	19	adult	adult	NOUN
cord-018764-02l423mk	354	20	malaria	malaria	NOUN
cord-018764-02l423mk	354	21	malaria	malaria	NOUN
cord-018764-02l423mk	354	22	and	and	CCONJ
cord-018764-02l423mk	354	23	the	the	DET
cord-018764-02l423mk	354	24	lung	lung	NOUN
cord-018764-02l423mk	354	25	indicators	indicator	NOUN
cord-018764-02l423mk	354	26	of	of	ADP
cord-018764-02l423mk	354	27	mortality	mortality	NOUN
cord-018764-02l423mk	354	28	in	in	ADP
cord-018764-02l423mk	354	29	african	african	ADJ
cord-018764-02l423mk	354	30	adults	adult	NOUN
cord-018764-02l423mk	354	31	with	with	ADP
cord-018764-02l423mk	354	32	malaria	malaria	NOUN
cord-018764-02l423mk	354	33	severe	severe	ADJ
cord-018764-02l423mk	354	34	falciparum	falciparum	NOUN
cord-018764-02l423mk	354	35	malaria	malaria	NOUN
cord-018764-02l423mk	354	36	in	in	ADP
cord-018764-02l423mk	354	37	children	child	NOUN
cord-018764-02l423mk	354	38	:	:	PUNCT
cord-018764-02l423mk	354	39	current	current	ADJ
cord-018764-02l423mk	354	40	understanding	understanding	NOUN
cord-018764-02l423mk	354	41	of	of	ADP
cord-018764-02l423mk	354	42	pathophysiology	pathophysiology	NOUN
cord-018764-02l423mk	354	43	and	and	CCONJ
cord-018764-02l423mk	354	44	supportive	supportive	ADJ
cord-018764-02l423mk	354	45	treatment	treatment	NOUN
cord-018764-02l423mk	354	46	the	the	DET
cord-018764-02l423mk	354	47	injured	injure	VERB
cord-018764-02l423mk	354	48	child	child	NOUN
cord-018764-02l423mk	354	49	is	be	AUX
cord-018764-02l423mk	354	50	resistant	resistant	ADJ
cord-018764-02l423mk	354	51	to	to	ADP
cord-018764-02l423mk	354	52	multiple	multiple	ADJ
cord-018764-02l423mk	354	53	organ	organ	NOUN
cord-018764-02l423mk	354	54	failure	failure	NOUN
cord-018764-02l423mk	354	55	:	:	PUNCT
cord-018764-02l423mk	354	56	a	a	DET
cord-018764-02l423mk	354	57	different	different	ADJ
cord-018764-02l423mk	354	58	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	354	59	response	response	NOUN
cord-018764-02l423mk	354	60	?	?	PUNCT
cord-018764-02l423mk	355	1	endotoxin	endotoxin	NOUN
cord-018764-02l423mk	355	2	induces	induce	VERB
cord-018764-02l423mk	355	3	an	an	DET
cord-018764-02l423mk	355	4	exaggerated	exaggerated	ADJ
cord-018764-02l423mk	355	5	interleukin-10	interleukin-10	SYM
cord-018764-02l423mk	355	6	response	response	NOUN
cord-018764-02l423mk	355	7	in	in	ADP
cord-018764-02l423mk	355	8	peritoneal	peritoneal	ADJ
cord-018764-02l423mk	355	9	macrophages	macrophage	NOUN
cord-018764-02l423mk	355	10	of	of	ADP
cord-018764-02l423mk	355	11	children	child	NOUN
cord-018764-02l423mk	355	12	compared	compare	VERB
cord-018764-02l423mk	355	13	with	with	ADP
cord-018764-02l423mk	355	14	adults	adult	NOUN
cord-018764-02l423mk	355	15	il-1	il-1	NOUN
cord-018764-02l423mk	356	1	beta	beta	NOUN
cord-018764-02l423mk	356	2	induces	induce	VERB
cord-018764-02l423mk	356	3	an	an	DET
cord-018764-02l423mk	356	4	exaggerated	exaggerated	ADJ
cord-018764-02l423mk	356	5	pro	pro	ADJ
cord-018764-02l423mk	356	6	-	-	ADJ
cord-018764-02l423mk	356	7	and	and	CCONJ
cord-018764-02l423mk	356	8	anti	anti	ADJ
cord-018764-02l423mk	356	9	-	-	ADJ
cord-018764-02l423mk	356	10	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	356	11	response	response	NOUN
cord-018764-02l423mk	356	12	in	in	ADP
cord-018764-02l423mk	356	13	peritoneal	peritoneal	ADJ
cord-018764-02l423mk	356	14	macrophages	macrophage	NOUN
cord-018764-02l423mk	356	15	of	of	ADP
cord-018764-02l423mk	356	16	children	child	NOUN
cord-018764-02l423mk	356	17	compared	compare	VERB
cord-018764-02l423mk	356	18	with	with	ADP
cord-018764-02l423mk	356	19	adults	adult	NOUN
cord-018764-02l423mk	356	20	current	current	ADJ
cord-018764-02l423mk	356	21	knowledge	knowledge	NOUN
cord-018764-02l423mk	356	22	in	in	ADP
cord-018764-02l423mk	356	23	falciparum	falciparum	NOUN
cord-018764-02l423mk	356	24	malaria	malaria	NOUN
cord-018764-02l423mk	356	25	-	-	PUNCT
cord-018764-02l423mk	356	26	induced	induce	VERB
cord-018764-02l423mk	356	27	acute	acute	ADJ
cord-018764-02l423mk	356	28	renal	renal	ADJ
cord-018764-02l423mk	356	29	failure	failure	NOUN
cord-018764-02l423mk	356	30	pediatric	pediatric	ADJ
cord-018764-02l423mk	356	31	considerations	consideration	NOUN
cord-018764-02l423mk	356	32	hypoglycemia	hypoglycemia	NOUN
cord-018764-02l423mk	356	33	in	in	ADP
cord-018764-02l423mk	356	34	infancy	infancy	NOUN
cord-018764-02l423mk	356	35	and	and	CCONJ
cord-018764-02l423mk	356	36	childhood	childhood	NOUN
cord-018764-02l423mk	356	37	glucose	glucose	NOUN
cord-018764-02l423mk	356	38	production	production	NOUN
cord-018764-02l423mk	356	39	and	and	CCONJ
cord-018764-02l423mk	356	40	gluconeogenesis	gluconeogenesis	NOUN
cord-018764-02l423mk	356	41	in	in	ADP
cord-018764-02l423mk	356	42	adults	adult	NOUN
cord-018764-02l423mk	356	43	with	with	ADP
cord-018764-02l423mk	356	44	uncomplicated	uncomplicated	ADJ
cord-018764-02l423mk	356	45	falciparum	falciparum	NOUN
cord-018764-02l423mk	356	46	malaria	malaria	NOUN
cord-018764-02l423mk	356	47	hypoglycaemia	hypoglycaemia	NOUN
cord-018764-02l423mk	356	48	in	in	ADP
cord-018764-02l423mk	356	49	african	african	ADJ
cord-018764-02l423mk	356	50	children	child	NOUN
cord-018764-02l423mk	356	51	with	with	ADP
cord-018764-02l423mk	356	52	severe	severe	ADJ
cord-018764-02l423mk	356	53	malaria	malaria	NOUN
cord-018764-02l423mk	356	54	severe	severe	ADJ
cord-018764-02l423mk	356	55	and	and	CCONJ
cord-018764-02l423mk	356	56	complicated	complicated	ADJ
cord-018764-02l423mk	356	57	falciparum	falciparum	NOUN
cord-018764-02l423mk	356	58	malaria	malaria	NOUN
cord-018764-02l423mk	356	59	in	in	ADP
cord-018764-02l423mk	356	60	melanesian	melanesian	ADJ
cord-018764-02l423mk	356	61	adults	adult	NOUN
cord-018764-02l423mk	356	62	in	in	ADP
cord-018764-02l423mk	356	63	papua	papua	ADJ
cord-018764-02l423mk	356	64	new	new	ADJ
cord-018764-02l423mk	356	65	guinea	guinea	NOUN
cord-018764-02l423mk	356	66	cerebral	cerebral	ADJ
cord-018764-02l423mk	356	67	malaria	malaria	NOUN
cord-018764-02l423mk	356	68	:	:	PUNCT
cord-018764-02l423mk	356	69	the	the	DET
cord-018764-02l423mk	356	70	sequestration	sequestration	NOUN
cord-018764-02l423mk	356	71	hypothesis	hypothesis	NOUN
cord-018764-02l423mk	356	72	the	the	DET
cord-018764-02l423mk	356	73	cytokine	cytokine	NOUN
cord-018764-02l423mk	356	74	theory	theory	NOUN
cord-018764-02l423mk	356	75	of	of	ADP
cord-018764-02l423mk	356	76	human	human	ADJ
cord-018764-02l423mk	356	77	cerebral	cerebral	ADJ
cord-018764-02l423mk	356	78	malaria	malaria	NOUN
cord-018764-02l423mk	356	79	golgi	golgi	PROPN
cord-018764-02l423mk	356	80	c	c	PROPN
cord-018764-02l423mk	356	81	(	(	PUNCT
cord-018764-02l423mk	356	82	1886	1886	NUM
cord-018764-02l423mk	356	83	)	)	PUNCT
cord-018764-02l423mk	356	84	sull	sull	VERB
cord-018764-02l423mk	356	85	infezione	infezione	NOUN
cord-018764-02l423mk	356	86	malarica	malarica	NOUN
cord-018764-02l423mk	356	87	the	the	DET
cord-018764-02l423mk	356	88	prevention	prevention	NOUN
cord-018764-02l423mk	356	89	of	of	ADP
cord-018764-02l423mk	356	90	malaria	malaria	NOUN
cord-018764-02l423mk	356	91	possible	possible	ADJ
cord-018764-02l423mk	356	92	importance	importance	NOUN
cord-018764-02l423mk	356	93	of	of	ADP
cord-018764-02l423mk	356	94	macrophage	macrophage	NOUN
cord-018764-02l423mk	356	95	-	-	PUNCT
cord-018764-02l423mk	356	96	derived	derive	VERB
cord-018764-02l423mk	356	97	mediators	mediator	NOUN
cord-018764-02l423mk	356	98	in	in	ADP
cord-018764-02l423mk	356	99	acute	acute	ADJ
cord-018764-02l423mk	356	100	malaria	malaria	NOUN
cord-018764-02l423mk	356	101	evolutionary	evolutionary	ADJ
cord-018764-02l423mk	356	102	causes	cause	NOUN
cord-018764-02l423mk	356	103	and	and	CCONJ
cord-018764-02l423mk	356	104	consequences	consequence	NOUN
cord-018764-02l423mk	356	105	of	of	ADP
cord-018764-02l423mk	356	106	immunopathology	immunopathology	NOUN
cord-018764-02l423mk	356	107	how	how	SCONJ
cord-018764-02l423mk	356	108	malaria	malaria	NOUN
cord-018764-02l423mk	356	109	has	have	AUX
cord-018764-02l423mk	356	110	affected	affect	VERB
cord-018764-02l423mk	356	111	the	the	DET
cord-018764-02l423mk	356	112	human	human	ADJ
cord-018764-02l423mk	356	113	genome	genome	NOUN
cord-018764-02l423mk	356	114	and	and	CCONJ
cord-018764-02l423mk	356	115	what	what	PRON
cord-018764-02l423mk	356	116	human	human	ADJ
cord-018764-02l423mk	356	117	genetics	genetic	NOUN
cord-018764-02l423mk	356	118	can	can	AUX
cord-018764-02l423mk	356	119	teach	teach	VERB
cord-018764-02l423mk	356	120	us	we	PRON
cord-018764-02l423mk	356	121	about	about	ADP
cord-018764-02l423mk	356	122	malaria	malaria	NOUN
cord-018764-02l423mk	356	123	a	a	DET
cord-018764-02l423mk	356	124	high	high	ADJ
cord-018764-02l423mk	356	125	frequency	frequency	NOUN
cord-018764-02l423mk	356	126	african	african	ADJ
cord-018764-02l423mk	356	127	coding	code	VERB
cord-018764-02l423mk	356	128	polymorphism	polymorphism	NOUN
cord-018764-02l423mk	356	129	in	in	ADP
cord-018764-02l423mk	356	130	the	the	DET
cord-018764-02l423mk	356	131	n	n	ADJ
cord-018764-02l423mk	356	132	-	-	ADJ
cord-018764-02l423mk	356	133	terminal	terminal	ADJ
cord-018764-02l423mk	356	134	domain	domain	NOUN
cord-018764-02l423mk	356	135	of	of	ADP
cord-018764-02l423mk	356	136	icam-1	icam-1	NUM
cord-018764-02l423mk	356	137	predisposing	predispose	VERB
cord-018764-02l423mk	356	138	to	to	ADP
cord-018764-02l423mk	356	139	cerebral	cerebral	ADJ
cord-018764-02l423mk	356	140	malaria	malaria	NOUN
cord-018764-02l423mk	356	141	in	in	ADP
cord-018764-02l423mk	356	142	kenya	kenya	PROPN
cord-018764-02l423mk	356	143	induction	induction	NOUN
cord-018764-02l423mk	356	144	of	of	ADP
cord-018764-02l423mk	356	145	cachectin	cachectin	PROPN
cord-018764-02l423mk	356	146	(	(	PUNCT
cord-018764-02l423mk	356	147	tumor	tumor	NOUN
cord-018764-02l423mk	356	148	necrosis	necrosis	NOUN
cord-018764-02l423mk	356	149	factor	factor	NOUN
cord-018764-02l423mk	356	150	)	)	PUNCT
cord-018764-02l423mk	356	151	synthesis	synthesis	NOUN
cord-018764-02l423mk	356	152	by	by	ADP
cord-018764-02l423mk	356	153	influenza	influenza	NOUN
cord-018764-02l423mk	356	154	virus	virus	NOUN
cord-018764-02l423mk	356	155	:	:	PUNCT
cord-018764-02l423mk	356	156	deficient	deficient	ADJ
cord-018764-02l423mk	356	157	production	production	NOUN
cord-018764-02l423mk	356	158	by	by	ADP
cord-018764-02l423mk	356	159	endotoxin	endotoxin	NOUN
cord-018764-02l423mk	356	160	-	-	PUNCT
cord-018764-02l423mk	356	161	resistant	resistant	ADJ
cord-018764-02l423mk	356	162	(	(	PUNCT
cord-018764-02l423mk	356	163	c3h	c3h	PROPN
cord-018764-02l423mk	356	164	/	/	SYM
cord-018764-02l423mk	356	165	hej	hej	PROPN
cord-018764-02l423mk	356	166	)	)	PUNCT
cord-018764-02l423mk	356	167	macrophages	macrophage	VERB
cord-018764-02l423mk	356	168	induction	induction	NOUN
cord-018764-02l423mk	356	169	of	of	ADP
cord-018764-02l423mk	356	170	proinflammatory	proinflammatory	ADJ
cord-018764-02l423mk	356	171	cytokines	cytokine	NOUN
cord-018764-02l423mk	356	172	in	in	ADP
cord-018764-02l423mk	356	173	human	human	ADJ
cord-018764-02l423mk	356	174	macrophages	macrophage	NOUN
cord-018764-02l423mk	356	175	by	by	ADP
cord-018764-02l423mk	356	176	influenza	influenza	NOUN
cord-018764-02l423mk	356	177	a	a	DET
cord-018764-02l423mk	356	178	(	(	PUNCT
cord-018764-02l423mk	356	179	h5n1	h5n1	PROPN
cord-018764-02l423mk	356	180	)	)	PUNCT
cord-018764-02l423mk	356	181	viruses	virus	NOUN
cord-018764-02l423mk	356	182	:	:	PUNCT
cord-018764-02l423mk	356	183	a	a	DET
cord-018764-02l423mk	356	184	mechanism	mechanism	NOUN
cord-018764-02l423mk	356	185	for	for	ADP
cord-018764-02l423mk	356	186	the	the	DET
cord-018764-02l423mk	356	187	unusual	unusual	ADJ
cord-018764-02l423mk	356	188	severity	severity	NOUN
cord-018764-02l423mk	356	189	of	of	ADP
cord-018764-02l423mk	356	190	human	human	ADJ
cord-018764-02l423mk	356	191	disease	disease	NOUN
cord-018764-02l423mk	356	192	recombinant	recombinant	ADJ
cord-018764-02l423mk	356	193	human	human	ADJ
cord-018764-02l423mk	356	194	tumor	tumor	NOUN
cord-018764-02l423mk	356	195	necrosis	necrosis	NOUN
cord-018764-02l423mk	356	196	factor	factor	NOUN
cord-018764-02l423mk	356	197	administered	administer	VERB
cord-018764-02l423mk	356	198	as	as	ADP
cord-018764-02l423mk	356	199	a	a	DET
cord-018764-02l423mk	356	200	24	24	NUM
cord-018764-02l423mk	356	201	-	-	PUNCT
cord-018764-02l423mk	356	202	hour	hour	NOUN
cord-018764-02l423mk	356	203	intravenous	intravenous	ADJ
cord-018764-02l423mk	356	204	infusion	infusion	NOUN
cord-018764-02l423mk	356	205	.	.	PUNCT
cord-018764-02l423mk	357	1	a	a	DET
cord-018764-02l423mk	357	2	phase	phase	NOUN
cord-018764-02l423mk	357	3	1	1	NUM
cord-018764-02l423mk	357	4	and	and	CCONJ
cord-018764-02l423mk	357	5	pharmacologic	pharmacologic	ADJ
cord-018764-02l423mk	357	6	study	study	NOUN
cord-018764-02l423mk	357	7	innate	innate	VERB
cord-018764-02l423mk	357	8	immunity	immunity	NOUN
cord-018764-02l423mk	357	9	to	to	ADP
cord-018764-02l423mk	357	10	malaria	malaria	PROPN
cord-018764-02l423mk	357	11	ifngr1	ifngr1	PROPN
cord-018764-02l423mk	357	12	gene	gene	NOUN
cord-018764-02l423mk	357	13	promoter	promoter	NOUN
cord-018764-02l423mk	357	14	polymorphisms	polymorphism	NOUN
cord-018764-02l423mk	357	15	and	and	CCONJ
cord-018764-02l423mk	357	16	susceptibility	susceptibility	NOUN
cord-018764-02l423mk	357	17	to	to	ADP
cord-018764-02l423mk	357	18	cerebral	cerebral	ADJ
cord-018764-02l423mk	357	19	malaria	malaria	NOUN
cord-018764-02l423mk	357	20	interferon	interferon	NOUN
cord-018764-02l423mk	357	21	-	-	PUNCT
cord-018764-02l423mk	357	22	alpha	alpha	NOUN
cord-018764-02l423mk	357	23	receptor-1	receptor-1	NUM
cord-018764-02l423mk	357	24	(	(	PUNCT
cord-018764-02l423mk	357	25	ifnar1	ifnar1	PROPN
cord-018764-02l423mk	357	26	)	)	PUNCT
cord-018764-02l423mk	357	27	variants	variant	NOUN
cord-018764-02l423mk	357	28	are	be	AUX
cord-018764-02l423mk	357	29	associated	associate	VERB
cord-018764-02l423mk	357	30	with	with	ADP
cord-018764-02l423mk	357	31	protection	protection	NOUN
cord-018764-02l423mk	357	32	against	against	ADP
cord-018764-02l423mk	357	33	cerebral	cerebral	ADJ
cord-018764-02l423mk	357	34	malaria	malaria	NOUN
cord-018764-02l423mk	357	35	in	in	ADP
cord-018764-02l423mk	357	36	the	the	DET
cord-018764-02l423mk	357	37	gambia	gambia	PROPN
cord-018764-02l423mk	357	38	interleukin-1	interleukin-1	PROPN
cord-018764-02l423mk	357	39	gene	gene	NOUN
cord-018764-02l423mk	357	40	cluster	cluster	NOUN
cord-018764-02l423mk	357	41	polymorphisms	polymorphism	NOUN
cord-018764-02l423mk	357	42	and	and	CCONJ
cord-018764-02l423mk	357	43	susceptibility	susceptibility	NOUN
cord-018764-02l423mk	357	44	to	to	ADP
cord-018764-02l423mk	357	45	clinical	clinical	ADJ
cord-018764-02l423mk	357	46	malaria	malaria	NOUN
cord-018764-02l423mk	357	47	in	in	ADP
cord-018764-02l423mk	357	48	a	a	DET
cord-018764-02l423mk	357	49	gambian	gambian	ADJ
cord-018764-02l423mk	357	50	case	case	NOUN
cord-018764-02l423mk	357	51	-	-	PUNCT
cord-018764-02l423mk	357	52	control	control	NOUN
cord-018764-02l423mk	357	53	study	study	NOUN
cord-018764-02l423mk	357	54	antimalarial	antimalarial	ADJ
cord-018764-02l423mk	357	55	antibody	antibody	NOUN
cord-018764-02l423mk	357	56	levels	level	NOUN
cord-018764-02l423mk	357	57	and	and	CCONJ
cord-018764-02l423mk	357	58	il-4	il-4	NOUN
cord-018764-02l423mk	357	59	polymorphism	polymorphism	NOUN
cord-018764-02l423mk	357	60	in	in	ADP
cord-018764-02l423mk	357	61	the	the	DET
cord-018764-02l423mk	357	62	fulani	fulani	NOUN
cord-018764-02l423mk	357	63	of	of	ADP
cord-018764-02l423mk	357	64	west	west	PROPN
cord-018764-02l423mk	357	65	africa	africa	PROPN
cord-018764-02l423mk	357	66	analysis	analysis	NOUN
cord-018764-02l423mk	357	67	of	of	ADP
cord-018764-02l423mk	357	68	il10	il10	PROPN
cord-018764-02l423mk	357	69	haplotypic	haplotypic	ADJ
cord-018764-02l423mk	357	70	associations	association	NOUN
cord-018764-02l423mk	357	71	with	with	ADP
cord-018764-02l423mk	357	72	severe	severe	ADJ
cord-018764-02l423mk	357	73	malaria	malaria	NOUN
cord-018764-02l423mk	357	74	hmg-1	hmg-1	PUNCT
cord-018764-02l423mk	357	75	as	as	SCONJ
cord-018764-02l423mk	357	76	a	a	DET
cord-018764-02l423mk	357	77	late	late	ADJ
cord-018764-02l423mk	357	78	mediator	mediator	NOUN
cord-018764-02l423mk	357	79	of	of	ADP
cord-018764-02l423mk	357	80	endotoxin	endotoxin	NOUN
cord-018764-02l423mk	357	81	lethality	lethality	NOUN
cord-018764-02l423mk	357	82	in	in	ADP
cord-018764-02l423mk	357	83	mice	mouse	NOUN
cord-018764-02l423mk	357	84	high	high	ADJ
cord-018764-02l423mk	357	85	mobility	mobility	NOUN
cord-018764-02l423mk	357	86	group	group	NOUN
cord-018764-02l423mk	357	87	1	1	NUM
cord-018764-02l423mk	357	88	protein	protein	NOUN
cord-018764-02l423mk	357	89	(	(	PUNCT
cord-018764-02l423mk	357	90	hmg-1	hmg-1	X
cord-018764-02l423mk	357	91	)	)	PUNCT
cord-018764-02l423mk	357	92	stimulates	stimulate	VERB
cord-018764-02l423mk	357	93	proinflammatory	proinflammatory	ADJ
cord-018764-02l423mk	357	94	cytokine	cytokine	NOUN
cord-018764-02l423mk	357	95	synthesis	synthesis	NOUN
cord-018764-02l423mk	357	96	in	in	ADP
cord-018764-02l423mk	357	97	human	human	ADJ
cord-018764-02l423mk	357	98	monocytes	monocyte	NOUN
cord-018764-02l423mk	357	99	ethyl	ethyl	PROPN
cord-018764-02l423mk	357	100	pyruvate	pyruvate	PROPN
cord-018764-02l423mk	357	101	protects	protect	VERB
cord-018764-02l423mk	357	102	against	against	ADP
cord-018764-02l423mk	357	103	lethal	lethal	ADJ
cord-018764-02l423mk	357	104	systemic	systemic	ADJ
cord-018764-02l423mk	357	105	inflammation	inflammation	NOUN
cord-018764-02l423mk	357	106	by	by	ADP
cord-018764-02l423mk	357	107	preventing	prevent	VERB
cord-018764-02l423mk	357	108	hmgb1	hmgb1	NOUN
cord-018764-02l423mk	357	109	release	release	NOUN
cord-018764-02l423mk	357	110	hmgb-1	hmgb-1	NUM
cord-018764-02l423mk	357	111	as	as	ADP
cord-018764-02l423mk	357	112	a	a	DET
cord-018764-02l423mk	357	113	therapeutic	therapeutic	ADJ
cord-018764-02l423mk	357	114	target	target	NOUN
cord-018764-02l423mk	357	115	for	for	ADP
cord-018764-02l423mk	357	116	infectious	infectious	ADJ
cord-018764-02l423mk	357	117	and	and	CCONJ
cord-018764-02l423mk	357	118	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	357	119	disorders	disorder	NOUN
cord-018764-02l423mk	357	120	high	high	ADJ
cord-018764-02l423mk	357	121	mobility	mobility	NOUN
cord-018764-02l423mk	357	122	group	group	NOUN
cord-018764-02l423mk	357	123	box	box	PROPN
cord-018764-02l423mk	357	124	1	1	NUM
cord-018764-02l423mk	357	125	(	(	PUNCT
cord-018764-02l423mk	357	126	hmgb1	hmgb1	PROPN
cord-018764-02l423mk	357	127	)	)	PUNCT
cord-018764-02l423mk	357	128	protein	protein	NOUN
cord-018764-02l423mk	357	129	:	:	PUNCT
cord-018764-02l423mk	357	130	possible	possible	ADJ
cord-018764-02l423mk	357	131	amplification	amplification	NOUN
cord-018764-02l423mk	357	132	signal	signal	NOUN
cord-018764-02l423mk	357	133	in	in	ADP
cord-018764-02l423mk	357	134	the	the	DET
cord-018764-02l423mk	357	135	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	357	136	of	of	ADP
cord-018764-02l423mk	357	137	falciparum	falciparum	NOUN
cord-018764-02l423mk	357	138	malaria	malaria	NOUN
cord-018764-02l423mk	357	139	inhibition	inhibition	NOUN
cord-018764-02l423mk	357	140	of	of	ADP
cord-018764-02l423mk	357	141	murine	murine	NOUN
cord-018764-02l423mk	357	142	malaria	malaria	NOUN
cord-018764-02l423mk	357	143	(	(	PUNCT
cord-018764-02l423mk	357	144	plasmodium	plasmodium	PROPN
cord-018764-02l423mk	357	145	chabaudi	chabaudi	NOUN
cord-018764-02l423mk	357	146	)	)	PUNCT
cord-018764-02l423mk	357	147	in	in	ADP
cord-018764-02l423mk	357	148	vivo	vivo	NOUN
cord-018764-02l423mk	357	149	by	by	ADP
cord-018764-02l423mk	357	150	recombinant	recombinant	ADJ
cord-018764-02l423mk	357	151	interferon	interferon	NOUN
cord-018764-02l423mk	357	152	-	-	PUNCT
cord-018764-02l423mk	357	153	gamma	gamma	NOUN
cord-018764-02l423mk	357	154	or	or	CCONJ
cord-018764-02l423mk	357	155	tumor	tumor	NOUN
cord-018764-02l423mk	357	156	necrosis	necrosis	NOUN
cord-018764-02l423mk	357	157	factor	factor	NOUN
cord-018764-02l423mk	357	158	,	,	PUNCT
cord-018764-02l423mk	357	159	and	and	CCONJ
cord-018764-02l423mk	357	160	its	its	PRON
cord-018764-02l423mk	357	161	enhancement	enhancement	NOUN
cord-018764-02l423mk	357	162	by	by	ADP
cord-018764-02l423mk	357	163	butylated	butylate	VERB
cord-018764-02l423mk	357	164	hydroxyanisole	hydroxyanisole	NOUN
cord-018764-02l423mk	357	165	killing	killing	NOUN
cord-018764-02l423mk	357	166	of	of	ADP
cord-018764-02l423mk	357	167	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	357	168	falciparum	falciparum	NOUN
cord-018764-02l423mk	357	169	in	in	ADP
cord-018764-02l423mk	357	170	vitro	vitro	X
cord-018764-02l423mk	357	171	by	by	ADP
cord-018764-02l423mk	357	172	nitric	nitric	NOUN
cord-018764-02l423mk	357	173	oxide	oxide	NOUN
cord-018764-02l423mk	357	174	derivatives	derivative	NOUN
cord-018764-02l423mk	357	175	influence	influence	NOUN
cord-018764-02l423mk	357	176	of	of	ADP
cord-018764-02l423mk	357	177	tumor	tumor	NOUN
cord-018764-02l423mk	357	178	necrosis	necrosis	NOUN
cord-018764-02l423mk	357	179	factor	factor	NOUN
cord-018764-02l423mk	357	180	-	-	PUNCT
cord-018764-02l423mk	357	181	alpha	alpha	NOUN
cord-018764-02l423mk	357	182	on	on	ADP
cord-018764-02l423mk	357	183	the	the	DET
cord-018764-02l423mk	357	184	ability	ability	NOUN
cord-018764-02l423mk	357	185	of	of	ADP
cord-018764-02l423mk	357	186	monocytes	monocyte	NOUN
cord-018764-02l423mk	357	187	and	and	CCONJ
cord-018764-02l423mk	357	188	lymphocytes	lymphocyte	NOUN
cord-018764-02l423mk	357	189	to	to	PART
cord-018764-02l423mk	357	190	destroy	destroy	VERB
cord-018764-02l423mk	357	191	intraerythrocytic	intraerythrocytic	ADJ
cord-018764-02l423mk	357	192	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	357	193	falciparum	falciparum	NOUN
cord-018764-02l423mk	357	194	in	in	ADP
cord-018764-02l423mk	357	195	vitro	vitro	X
cord-018764-02l423mk	357	196	immunity	immunity	NOUN
cord-018764-02l423mk	357	197	to	to	ADP
cord-018764-02l423mk	357	198	malaria	malaria	NOUN
cord-018764-02l423mk	357	199	after	after	ADP
cord-018764-02l423mk	357	200	administration	administration	NOUN
cord-018764-02l423mk	357	201	of	of	ADP
cord-018764-02l423mk	357	202	ultra	ultra	ADJ
cord-018764-02l423mk	357	203	-	-	ADJ
cord-018764-02l423mk	357	204	low	low	ADJ
cord-018764-02l423mk	357	205	doses	dose	NOUN
cord-018764-02l423mk	357	206	of	of	ADP
cord-018764-02l423mk	357	207	red	red	ADJ
cord-018764-02l423mk	357	208	cells	cell	NOUN
cord-018764-02l423mk	357	209	infected	infect	VERB
cord-018764-02l423mk	357	210	with	with	ADP
cord-018764-02l423mk	357	211	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	357	212	falciparum	falciparum	NOUN
cord-018764-02l423mk	357	213	the	the	DET
cord-018764-02l423mk	357	214	effect	effect	NOUN
cord-018764-02l423mk	357	215	of	of	ADP
cord-018764-02l423mk	357	216	a	a	DET
cord-018764-02l423mk	357	217	monoclonal	monoclonal	NOUN
cord-018764-02l423mk	357	218	antibody	antibody	NOUN
cord-018764-02l423mk	357	219	to	to	ADP
cord-018764-02l423mk	357	220	tumor	tumor	NOUN
cord-018764-02l423mk	357	221	necrosis	necrosis	NOUN
cord-018764-02l423mk	357	222	factor	factor	NOUN
cord-018764-02l423mk	357	223	on	on	ADP
cord-018764-02l423mk	357	224	survival	survival	NOUN
cord-018764-02l423mk	357	225	from	from	ADP
cord-018764-02l423mk	357	226	childhood	childhood	NOUN
cord-018764-02l423mk	357	227	cerebral	cerebral	ADJ
cord-018764-02l423mk	357	228	malaria	malaria	NOUN
cord-018764-02l423mk	357	229	treatment	treatment	NOUN
cord-018764-02l423mk	357	230	of	of	ADP
cord-018764-02l423mk	357	231	septic	septic	ADJ
cord-018764-02l423mk	357	232	shock	shock	NOUN
cord-018764-02l423mk	357	233	with	with	ADP
cord-018764-02l423mk	357	234	the	the	DET
cord-018764-02l423mk	357	235	tumor	tumor	NOUN
cord-018764-02l423mk	357	236	necrosis	necrosis	NOUN
cord-018764-02l423mk	357	237	factor	factor	NOUN
cord-018764-02l423mk	357	238	receptor	receptor	NOUN
cord-018764-02l423mk	357	239	:	:	PUNCT
cord-018764-02l423mk	357	240	fc	fc	PROPN
cord-018764-02l423mk	357	241	fusion	fusion	NOUN
cord-018764-02l423mk	357	242	protein	protein	NOUN
cord-018764-02l423mk	357	243	disease	disease	NOUN
cord-018764-02l423mk	357	244	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	357	245	in	in	ADP
cord-018764-02l423mk	357	246	malaria	malaria	NOUN
cord-018764-02l423mk	357	247	and	and	CCONJ
cord-018764-02l423mk	357	248	clinically	clinically	ADV
cord-018764-02l423mk	357	249	similar	similar	ADJ
cord-018764-02l423mk	357	250	conditions	condition	NOUN
cord-018764-02l423mk	357	251	tumour	tumour	NOUN
cord-018764-02l423mk	357	252	necrosis	necrosis	NOUN
cord-018764-02l423mk	357	253	factor	factor	NOUN
cord-018764-02l423mk	357	254	and	and	CCONJ
cord-018764-02l423mk	357	255	related	relate	VERB
cord-018764-02l423mk	357	256	cytokines	cytokine	NOUN
cord-018764-02l423mk	357	257	a	a	DET
cord-018764-02l423mk	357	258	phase	phase	NOUN
cord-018764-02l423mk	357	259	1	1	NUM
cord-018764-02l423mk	357	260	clinical	clinical	ADJ
cord-018764-02l423mk	357	261	trial	trial	NOUN
cord-018764-02l423mk	357	262	of	of	ADP
cord-018764-02l423mk	357	263	recombinant	recombinant	ADJ
cord-018764-02l423mk	357	264	human	human	ADJ
cord-018764-02l423mk	357	265	tumor	tumor	NOUN
cord-018764-02l423mk	357	266	necrosis	necrosis	NOUN
cord-018764-02l423mk	357	267	factor	factor	NOUN
cord-018764-02l423mk	357	268	clinical	clinical	ADJ
cord-018764-02l423mk	357	269	features	feature	NOUN
cord-018764-02l423mk	357	270	can	can	AUX
cord-018764-02l423mk	357	271	not	not	PART
cord-018764-02l423mk	357	272	predict	predict	VERB
cord-018764-02l423mk	357	273	a	a	DET
cord-018764-02l423mk	357	274	diagnosis	diagnosis	NOUN
cord-018764-02l423mk	357	275	of	of	ADP
cord-018764-02l423mk	357	276	malaria	malaria	NOUN
cord-018764-02l423mk	357	277	or	or	CCONJ
cord-018764-02l423mk	357	278	differentiate	differentiate	VERB
cord-018764-02l423mk	357	279	the	the	DET
cord-018764-02l423mk	357	280	infecting	infect	VERB
cord-018764-02l423mk	357	281	species	specie	NOUN
cord-018764-02l423mk	357	282	in	in	ADP
cord-018764-02l423mk	357	283	children	child	NOUN
cord-018764-02l423mk	357	284	living	live	VERB
cord-018764-02l423mk	357	285	in	in	ADP
cord-018764-02l423mk	357	286	an	an	DET
cord-018764-02l423mk	357	287	area	area	NOUN
cord-018764-02l423mk	357	288	of	of	ADP
cord-018764-02l423mk	357	289	low	low	ADJ
cord-018764-02l423mk	357	290	transmission	transmission	NOUN
cord-018764-02l423mk	357	291	a	a	DET
cord-018764-02l423mk	357	292	human	human	ADJ
cord-018764-02l423mk	357	293	88	88	NUM
cord-018764-02l423mk	357	294	-	-	PUNCT
cord-018764-02l423mk	357	295	kd	kd	NOUN
cord-018764-02l423mk	357	296	membrane	membrane	NOUN
cord-018764-02l423mk	357	297	glycoprotein	glycoprotein	NOUN
cord-018764-02l423mk	357	298	(	(	PUNCT
cord-018764-02l423mk	357	299	cd36	cd36	PROPN
cord-018764-02l423mk	357	300	)	)	PUNCT
cord-018764-02l423mk	357	301	functions	function	NOUN
cord-018764-02l423mk	357	302	in	in	ADP
cord-018764-02l423mk	357	303	vitro	vitro	X
cord-018764-02l423mk	357	304	as	as	ADP
cord-018764-02l423mk	357	305	a	a	DET
cord-018764-02l423mk	357	306	receptor	receptor	NOUN
cord-018764-02l423mk	357	307	for	for	ADP
cord-018764-02l423mk	357	308	a	a	DET
cord-018764-02l423mk	357	309	cytoadherence	cytoadherence	NOUN
cord-018764-02l423mk	357	310	ligand	ligand	NOUN
cord-018764-02l423mk	357	311	on	on	ADP
cord-018764-02l423mk	357	312	plasmodium	plasmodium	PROPN
cord-018764-02l423mk	357	313	falciparum	falciparum	NOUN
cord-018764-02l423mk	357	314	-	-	PUNCT
cord-018764-02l423mk	357	315	infected	infect	VERB
cord-018764-02l423mk	357	316	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	357	317	thrombospondin	thrombospondin	VERB
cord-018764-02l423mk	357	318	binds	bind	VERB
cord-018764-02l423mk	357	319	falciparum	falciparum	NOUN
cord-018764-02l423mk	357	320	malaria	malaria	NOUN
cord-018764-02l423mk	357	321	parasitized	parasitize	VERB
cord-018764-02l423mk	357	322	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	357	323	and	and	CCONJ
cord-018764-02l423mk	357	324	may	may	AUX
cord-018764-02l423mk	357	325	mediate	mediate	VERB
cord-018764-02l423mk	357	326	cytoadherence	cytoadherence	PROPN
cord-018764-02l423mk	357	327	receptor	receptor	NOUN
cord-018764-02l423mk	357	328	-	-	PUNCT
cord-018764-02l423mk	357	329	specific	specific	ADJ
cord-018764-02l423mk	357	330	adhesion	adhesion	NOUN
cord-018764-02l423mk	357	331	and	and	CCONJ
cord-018764-02l423mk	357	332	clinical	clinical	ADJ
cord-018764-02l423mk	357	333	disease	disease	NOUN
cord-018764-02l423mk	357	334	in	in	ADP
cord-018764-02l423mk	357	335	plasmodium	plasmodium	ADJ
cord-018764-02l423mk	357	336	falciparum	falciparum	NOUN
cord-018764-02l423mk	357	337	intercellular	intercellular	ADJ
cord-018764-02l423mk	357	338	adhesion	adhesion	NOUN
cord-018764-02l423mk	357	339	molecule-1	molecule-1	PROPN
cord-018764-02l423mk	357	340	is	be	AUX
cord-018764-02l423mk	357	341	an	an	DET
cord-018764-02l423mk	357	342	endothelial	endothelial	ADJ
cord-018764-02l423mk	357	343	cell	cell	NOUN
cord-018764-02l423mk	357	344	adhesion	adhesion	NOUN
cord-018764-02l423mk	357	345	receptor	receptor	NOUN
cord-018764-02l423mk	357	346	for	for	ADP
cord-018764-02l423mk	357	347	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	357	348	falciparum	falciparum	NOUN
cord-018764-02l423mk	357	349	human	human	ADJ
cord-018764-02l423mk	357	350	vascular	vascular	ADJ
cord-018764-02l423mk	357	351	endothelial	endothelial	ADJ
cord-018764-02l423mk	357	352	cell	cell	NOUN
cord-018764-02l423mk	357	353	adhesion	adhesion	NOUN
cord-018764-02l423mk	357	354	receptors	receptor	NOUN
cord-018764-02l423mk	357	355	for	for	ADP
cord-018764-02l423mk	357	356	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	357	357	falciparum	falciparum	NOUN
cord-018764-02l423mk	357	358	-	-	PUNCT
cord-018764-02l423mk	357	359	infected	infect	VERB
cord-018764-02l423mk	357	360	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	357	361	:	:	PUNCT
cord-018764-02l423mk	357	362	roles	role	NOUN
cord-018764-02l423mk	357	363	for	for	ADP
cord-018764-02l423mk	357	364	endothelial	endothelial	ADJ
cord-018764-02l423mk	357	365	leukocyte	leukocyte	NOUN
cord-018764-02l423mk	357	366	adhesion	adhesion	NOUN
cord-018764-02l423mk	357	367	molecule	molecule	NOUN
cord-018764-02l423mk	357	368	1	1	NUM
cord-018764-02l423mk	357	369	and	and	CCONJ
cord-018764-02l423mk	357	370	vascular	vascular	ADJ
cord-018764-02l423mk	357	371	cell	cell	NOUN
cord-018764-02l423mk	357	372	adhesion	adhesion	NOUN
cord-018764-02l423mk	357	373	molecule	molecule	NOUN
cord-018764-02l423mk	357	374	1	1	NUM
cord-018764-02l423mk	357	375	human	human	ADJ
cord-018764-02l423mk	357	376	cerebral	cerebral	ADJ
cord-018764-02l423mk	357	377	malaria	malaria	NOUN
cord-018764-02l423mk	357	378	:	:	PUNCT
cord-018764-02l423mk	357	379	associated	associate	VERB
cord-018764-02l423mk	357	380	with	with	ADP
cord-018764-02l423mk	357	381	erythrocyte	erythrocyte	NOUN
cord-018764-02l423mk	357	382	rosetting	rosette	VERB
cord-018764-02l423mk	357	383	and	and	CCONJ
cord-018764-02l423mk	357	384	lack	lack	NOUN
cord-018764-02l423mk	357	385	of	of	ADP
cord-018764-02l423mk	357	386	anti	anti	ADJ
cord-018764-02l423mk	357	387	-	-	ADJ
cord-018764-02l423mk	357	388	rosetting	rosette	VERB
cord-018764-02l423mk	357	389	antibodies	antibodie	VERB
cord-018764-02l423mk	357	390	platelet	platelet	NOUN
cord-018764-02l423mk	357	391	-	-	PUNCT
cord-018764-02l423mk	357	392	mediated	mediate	VERB
cord-018764-02l423mk	357	393	clumping	clumping	NOUN
cord-018764-02l423mk	357	394	of	of	ADP
cord-018764-02l423mk	357	395	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	357	396	falciparum	falciparum	NOUN
cord-018764-02l423mk	357	397	-	-	PUNCT
cord-018764-02l423mk	357	398	infected	infect	VERB
cord-018764-02l423mk	357	399	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	357	400	is	be	AUX
cord-018764-02l423mk	357	401	a	a	DET
cord-018764-02l423mk	357	402	common	common	ADJ
cord-018764-02l423mk	357	403	adhesive	adhesive	ADJ
cord-018764-02l423mk	357	404	phonotype	phonotype	NOUN
cord-018764-02l423mk	357	405	and	and	CCONJ
cord-018764-02l423mk	357	406	is	be	AUX
cord-018764-02l423mk	357	407	associated	associate	VERB
cord-018764-02l423mk	357	408	with	with	ADP
cord-018764-02l423mk	357	409	severe	severe	ADJ
cord-018764-02l423mk	357	410	malaria	malaria	NOUN
cord-018764-02l423mk	357	411	a	a	DET
cord-018764-02l423mk	357	412	non	non	ADJ
cord-018764-02l423mk	357	413	-	-	ADJ
cord-018764-02l423mk	357	414	sense	sense	ADJ
cord-018764-02l423mk	357	415	mutation	mutation	NOUN
cord-018764-02l423mk	357	416	in	in	ADP
cord-018764-02l423mk	357	417	cd36	cd36	ADJ
cord-018764-02l423mk	357	418	gene	gene	NOUN
cord-018764-02l423mk	357	419	is	be	AUX
cord-018764-02l423mk	357	420	associated	associate	VERB
cord-018764-02l423mk	357	421	with	with	ADP
cord-018764-02l423mk	357	422	protection	protection	NOUN
cord-018764-02l423mk	357	423	from	from	ADP
cord-018764-02l423mk	357	424	severe	severe	ADJ
cord-018764-02l423mk	357	425	malaria	malaria	NOUN
cord-018764-02l423mk	357	426	increased	increase	VERB
cord-018764-02l423mk	357	427	plasma	plasma	NOUN
cord-018764-02l423mk	357	428	concentrations	concentration	NOUN
cord-018764-02l423mk	357	429	of	of	ADP
cord-018764-02l423mk	357	430	sicam-1	sicam-1	NUM
cord-018764-02l423mk	357	431	,	,	PUNCT
cord-018764-02l423mk	357	432	svcam-1	svcam-1	NUM
cord-018764-02l423mk	357	433	and	and	CCONJ
cord-018764-02l423mk	357	434	selam-1	selam-1	NOUN
cord-018764-02l423mk	357	435	in	in	ADP
cord-018764-02l423mk	357	436	patients	patient	NOUN
cord-018764-02l423mk	357	437	with	with	ADP
cord-018764-02l423mk	357	438	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	357	439	falciparum	falciparum	NOUN
cord-018764-02l423mk	357	440	or	or	CCONJ
cord-018764-02l423mk	357	441	p.	p.	PROPN
cord-018764-02l423mk	357	442	vivax	vivax	PROPN
cord-018764-02l423mk	357	443	malaria	malaria	NOUN
cord-018764-02l423mk	357	444	and	and	CCONJ
cord-018764-02l423mk	357	445	association	association	NOUN
cord-018764-02l423mk	357	446	with	with	ADP
cord-018764-02l423mk	357	447	disease	disease	NOUN
cord-018764-02l423mk	357	448	severity	severity	NOUN
cord-018764-02l423mk	357	449	possible	possible	ADJ
cord-018764-02l423mk	357	450	involvement	involvement	NOUN
cord-018764-02l423mk	357	451	of	of	ADP
cord-018764-02l423mk	357	452	cytokines	cytokine	NOUN
cord-018764-02l423mk	357	453	in	in	ADP
cord-018764-02l423mk	357	454	diffuse	diffuse	NOUN
cord-018764-02l423mk	357	455	intravascular	intravascular	ADJ
cord-018764-02l423mk	357	456	coagulation	coagulation	NOUN
cord-018764-02l423mk	357	457	and	and	CCONJ
cord-018764-02l423mk	357	458	thrombosis	thrombosis	NOUN
cord-018764-02l423mk	357	459	tissue	tissue	NOUN
cord-018764-02l423mk	357	460	factor	factor	NOUN
cord-018764-02l423mk	357	461	in	in	ADP
cord-018764-02l423mk	357	462	infection	infection	NOUN
cord-018764-02l423mk	357	463	and	and	CCONJ
cord-018764-02l423mk	357	464	severe	severe	ADJ
cord-018764-02l423mk	357	465	inflammation	inflammation	NOUN
cord-018764-02l423mk	357	466	transcriptional	transcriptional	NOUN
cord-018764-02l423mk	357	467	expression	expression	NOUN
cord-018764-02l423mk	357	468	of	of	ADP
cord-018764-02l423mk	357	469	tissue	tissue	NOUN
cord-018764-02l423mk	357	470	factor	factor	NOUN
cord-018764-02l423mk	357	471	pathway	pathway	PROPN
cord-018764-02l423mk	357	472	inhibitor	inhibitor	NOUN
cord-018764-02l423mk	357	473	,	,	PUNCT
cord-018764-02l423mk	357	474	thrombomodulin	thrombomodulin	PROPN
cord-018764-02l423mk	357	475	and	and	CCONJ
cord-018764-02l423mk	357	476	von	von	PROPN
cord-018764-02l423mk	357	477	willebrand	willebrand	PROPN
cord-018764-02l423mk	357	478	factor	factor	NOUN
cord-018764-02l423mk	357	479	in	in	ADP
cord-018764-02l423mk	357	480	normal	normal	ADJ
cord-018764-02l423mk	357	481	human	human	ADJ
cord-018764-02l423mk	357	482	tissues	tissue	NOUN
cord-018764-02l423mk	357	483	thrombin	thrombin	NOUN
cord-018764-02l423mk	357	484	-	-	PUNCT
cord-018764-02l423mk	357	485	activated	activate	VERB
cord-018764-02l423mk	357	486	human	human	ADJ
cord-018764-02l423mk	357	487	endothelial	endothelial	ADJ
cord-018764-02l423mk	357	488	cells	cell	NOUN
cord-018764-02l423mk	357	489	support	support	VERB
cord-018764-02l423mk	357	490	monocyte	monocyte	NOUN
cord-018764-02l423mk	357	491	adhesion	adhesion	NOUN
cord-018764-02l423mk	357	492	in	in	ADP
cord-018764-02l423mk	357	493	vitro	vitro	X
cord-018764-02l423mk	357	494	following	follow	VERB
cord-018764-02l423mk	357	495	expression	expression	NOUN
cord-018764-02l423mk	357	496	of	of	ADP
cord-018764-02l423mk	357	497	intercellular	intercellular	ADJ
cord-018764-02l423mk	357	498	adhesion	adhesion	NOUN
cord-018764-02l423mk	357	499	molecule-1	molecule-1	NOUN
cord-018764-02l423mk	357	500	(	(	PUNCT
cord-018764-02l423mk	357	501	icam-1	icam-1	NUM
cord-018764-02l423mk	357	502	cd54	cd54	PROPN
cord-018764-02l423mk	357	503	)	)	PUNCT
cord-018764-02l423mk	357	504	and	and	CCONJ
cord-018764-02l423mk	357	505	vascular	vascular	ADJ
cord-018764-02l423mk	357	506	cell	cell	NOUN
cord-018764-02l423mk	357	507	adhesion	adhesion	NOUN
cord-018764-02l423mk	357	508	molecule-1	molecule-1	PROPN
cord-018764-02l423mk	357	509	(	(	PUNCT
cord-018764-02l423mk	358	1	vcam-1	vcam-1	NUM
cord-018764-02l423mk	358	2	cd106	cd106	NOUN
cord-018764-02l423mk	358	3	)	)	PUNCT
cord-018764-02l423mk	358	4	thrombin	thrombin	NOUN
cord-018764-02l423mk	358	5	stimulates	stimulate	VERB
cord-018764-02l423mk	358	6	proliferation	proliferation	NOUN
cord-018764-02l423mk	358	7	of	of	ADP
cord-018764-02l423mk	358	8	liver	liver	ADJ
cord-018764-02l423mk	358	9	fat	fat	NOUN
cord-018764-02l423mk	358	10	-	-	PUNCT
cord-018764-02l423mk	358	11	storing	store	VERB
cord-018764-02l423mk	358	12	cells	cell	NOUN
cord-018764-02l423mk	358	13	and	and	CCONJ
cord-018764-02l423mk	358	14	expression	expression	NOUN
cord-018764-02l423mk	358	15	of	of	ADP
cord-018764-02l423mk	358	16	monocyte	monocyte	NOUN
cord-018764-02l423mk	358	17	chemotactic	chemotactic	NOUN
cord-018764-02l423mk	358	18	protein-1	protein-1	NOUN
cord-018764-02l423mk	358	19	:	:	PUNCT
cord-018764-02l423mk	358	20	potential	potential	ADJ
cord-018764-02l423mk	358	21	role	role	NOUN
cord-018764-02l423mk	358	22	in	in	ADP
cord-018764-02l423mk	358	23	liver	liver	NOUN
cord-018764-02l423mk	358	24	injury	injury	NOUN
cord-018764-02l423mk	358	25	lactic	lactic	ADJ
cord-018764-02l423mk	358	26	acidosis	acidosis	NOUN
cord-018764-02l423mk	358	27	and	and	CCONJ
cord-018764-02l423mk	358	28	oxygen	oxygen	NOUN
cord-018764-02l423mk	358	29	debt	debt	NOUN
cord-018764-02l423mk	358	30	in	in	ADP
cord-018764-02l423mk	358	31	african	african	ADJ
cord-018764-02l423mk	358	32	children	child	NOUN
cord-018764-02l423mk	358	33	with	with	ADP
cord-018764-02l423mk	358	34	severe	severe	ADJ
cord-018764-02l423mk	358	35	anaemia	anaemia	NOUN
cord-018764-02l423mk	358	36	red	red	ADJ
cord-018764-02l423mk	358	37	blood	blood	NOUN
cord-018764-02l423mk	358	38	cell	cell	NOUN
cord-018764-02l423mk	358	39	physiology	physiology	NOUN
cord-018764-02l423mk	358	40	in	in	ADP
cord-018764-02l423mk	358	41	critical	critical	ADJ
cord-018764-02l423mk	358	42	illness	illness	NOUN
cord-018764-02l423mk	358	43	anaemia	anaemia	NOUN
cord-018764-02l423mk	358	44	and	and	CCONJ
cord-018764-02l423mk	358	45	resistance	resistance	NOUN
cord-018764-02l423mk	358	46	to	to	ADP
cord-018764-02l423mk	358	47	malaria	malaria	NOUN
cord-018764-02l423mk	358	48	in	in	ADP
cord-018764-02l423mk	358	49	transgenic	transgenic	ADJ
cord-018764-02l423mk	358	50	mice	mouse	NOUN
cord-018764-02l423mk	358	51	expressing	express	VERB
cord-018764-02l423mk	358	52	human	human	ADJ
cord-018764-02l423mk	358	53	tumour	tumour	NOUN
cord-018764-02l423mk	358	54	necrosis	necrosis	NOUN
cord-018764-02l423mk	358	55	factor	factor	NOUN
cord-018764-02l423mk	358	56	physiological	physiological	ADJ
cord-018764-02l423mk	358	57	studies	study	NOUN
cord-018764-02l423mk	358	58	in	in	ADP
cord-018764-02l423mk	358	59	the	the	DET
cord-018764-02l423mk	358	60	human	human	ADJ
cord-018764-02l423mk	358	61	malarial	malarial	ADJ
cord-018764-02l423mk	358	62	host	host	NOUN
cord-018764-02l423mk	358	63	alterations	alteration	NOUN
cord-018764-02l423mk	358	64	in	in	ADP
cord-018764-02l423mk	358	65	red	red	ADJ
cord-018764-02l423mk	358	66	blood	blood	NOUN
cord-018764-02l423mk	358	67	cell	cell	NOUN
cord-018764-02l423mk	358	68	sodium	sodium	NOUN
cord-018764-02l423mk	358	69	transport	transport	NOUN
cord-018764-02l423mk	358	70	during	during	ADP
cord-018764-02l423mk	358	71	malaria	malaria	NOUN
cord-018764-02l423mk	358	72	changes	change	NOUN
cord-018764-02l423mk	358	73	in	in	ADP
cord-018764-02l423mk	358	74	sodium	sodium	NOUN
cord-018764-02l423mk	358	75	,	,	PUNCT
cord-018764-02l423mk	358	76	potassium	potassium	NOUN
cord-018764-02l423mk	358	77	,	,	PUNCT
cord-018764-02l423mk	358	78	and	and	CCONJ
cord-018764-02l423mk	358	79	adenosine	adenosine	NOUN
cord-018764-02l423mk	358	80	triphosphate	triphosphate	ADJ
cord-018764-02l423mk	358	81	contents	content	NOUN
cord-018764-02l423mk	358	82	of	of	ADP
cord-018764-02l423mk	358	83	red	red	ADJ
cord-018764-02l423mk	358	84	blood	blood	NOUN
cord-018764-02l423mk	358	85	cells	cell	NOUN
cord-018764-02l423mk	358	86	in	in	ADP
cord-018764-02l423mk	358	87	sepsis	sepsis	NOUN
cord-018764-02l423mk	358	88	and	and	CCONJ
cord-018764-02l423mk	358	89	septic	septic	ADJ
cord-018764-02l423mk	358	90	shock	shock	NOUN
cord-018764-02l423mk	358	91	autocrine	autocrine	ADJ
cord-018764-02l423mk	358	92	inhibition	inhibition	NOUN
cord-018764-02l423mk	358	93	of	of	ADP
cord-018764-02l423mk	358	94	na	na	NOUN
cord-018764-02l423mk	358	95	+	+	CCONJ
cord-018764-02l423mk	358	96	/k	/k	PUNCT
cord-018764-02l423mk	359	1	+	+	PUNCT
cord-018764-02l423mk	359	2	-atpase	-atpase	NOUN
cord-018764-02l423mk	359	3	by	by	ADP
cord-018764-02l423mk	359	4	nitric	nitric	NOUN
cord-018764-02l423mk	359	5	oxide	oxide	NOUN
cord-018764-02l423mk	359	6	in	in	ADP
cord-018764-02l423mk	359	7	mouse	mouse	NOUN
cord-018764-02l423mk	359	8	proximal	proximal	ADJ
cord-018764-02l423mk	359	9	tubule	tubule	ADJ
cord-018764-02l423mk	359	10	epithelial	epithelial	ADJ
cord-018764-02l423mk	359	11	cells	cell	NOUN
cord-018764-02l423mk	359	12	erythrocyte	erythrocyte	NOUN
cord-018764-02l423mk	359	13	deformability	deformability	NOUN
cord-018764-02l423mk	359	14	is	be	AUX
cord-018764-02l423mk	359	15	a	a	DET
cord-018764-02l423mk	359	16	nitric	nitric	ADJ
cord-018764-02l423mk	359	17	oxide	oxide	NOUN
cord-018764-02l423mk	359	18	-	-	PUNCT
cord-018764-02l423mk	359	19	mediated	mediate	VERB
cord-018764-02l423mk	359	20	factor	factor	NOUN
cord-018764-02l423mk	359	21	in	in	ADP
cord-018764-02l423mk	359	22	decreased	decrease	VERB
cord-018764-02l423mk	359	23	capillary	capillary	ADJ
cord-018764-02l423mk	359	24	density	density	NOUN
cord-018764-02l423mk	359	25	during	during	ADP
cord-018764-02l423mk	359	26	sepsis	sepsis	NOUN
cord-018764-02l423mk	359	27	sodium	sodium	NOUN
cord-018764-02l423mk	359	28	transport	transport	NOUN
cord-018764-02l423mk	359	29	and	and	CCONJ
cord-018764-02l423mk	359	30	red	red	ADJ
cord-018764-02l423mk	359	31	cell	cell	NOUN
cord-018764-02l423mk	359	32	deformability	deformability	NOUN
cord-018764-02l423mk	359	33	red	red	ADJ
cord-018764-02l423mk	359	34	blood	blood	NOUN
cord-018764-02l423mk	359	35	cell	cell	NOUN
cord-018764-02l423mk	359	36	physiology	physiology	NOUN
cord-018764-02l423mk	359	37	in	in	ADP
cord-018764-02l423mk	359	38	critical	critical	ADJ
cord-018764-02l423mk	359	39	illness	illness	NOUN
cord-018764-02l423mk	359	40	diminished	diminish	VERB
cord-018764-02l423mk	359	41	red	red	ADJ
cord-018764-02l423mk	359	42	blood	blood	NOUN
cord-018764-02l423mk	359	43	cell	cell	NOUN
cord-018764-02l423mk	359	44	deformability	deformability	NOUN
cord-018764-02l423mk	359	45	in	in	ADP
cord-018764-02l423mk	359	46	uncomplicated	uncomplicated	ADJ
cord-018764-02l423mk	359	47	human	human	ADJ
cord-018764-02l423mk	359	48	malaria	malaria	NOUN
cord-018764-02l423mk	359	49	.	.	PUNCT
cord-018764-02l423mk	360	1	a	a	DET
cord-018764-02l423mk	360	2	preliminary	preliminary	ADJ
cord-018764-02l423mk	360	3	report	report	NOUN
cord-018764-02l423mk	360	4	alterations	alteration	NOUN
cord-018764-02l423mk	360	5	of	of	ADP
cord-018764-02l423mk	360	6	capillary	capillary	ADJ
cord-018764-02l423mk	360	7	flow	flow	NOUN
cord-018764-02l423mk	360	8	during	during	ADP
cord-018764-02l423mk	360	9	sepsis	sepsis	NOUN
cord-018764-02l423mk	360	10	red	red	ADJ
cord-018764-02l423mk	360	11	blood	blood	NOUN
cord-018764-02l423mk	360	12	cell	cell	NOUN
cord-018764-02l423mk	360	13	deformability	deformability	NOUN
cord-018764-02l423mk	360	14	in	in	ADP
cord-018764-02l423mk	360	15	human	human	ADJ
cord-018764-02l423mk	360	16	and	and	CCONJ
cord-018764-02l423mk	360	17	experimental	experimental	ADJ
cord-018764-02l423mk	360	18	sepsis	sepsis	NOUN
cord-018764-02l423mk	360	19	prognostic	prognostic	ADJ
cord-018764-02l423mk	360	20	significance	significance	NOUN
cord-018764-02l423mk	360	21	of	of	ADP
cord-018764-02l423mk	360	22	reduced	reduce	VERB
cord-018764-02l423mk	360	23	red	red	ADJ
cord-018764-02l423mk	360	24	blood	blood	NOUN
cord-018764-02l423mk	360	25	cell	cell	NOUN
cord-018764-02l423mk	360	26	deformability	deformability	NOUN
cord-018764-02l423mk	360	27	in	in	ADP
cord-018764-02l423mk	360	28	severe	severe	ADJ
cord-018764-02l423mk	360	29	falciparum	falciparum	NOUN
cord-018764-02l423mk	360	30	malaria	malaria	NOUN
cord-018764-02l423mk	360	31	red	red	ADJ
cord-018764-02l423mk	360	32	blood	blood	NOUN
cord-018764-02l423mk	360	33	cell	cell	NOUN
cord-018764-02l423mk	360	34	deformability	deformability	NOUN
cord-018764-02l423mk	360	35	as	as	ADP
cord-018764-02l423mk	360	36	a	a	DET
cord-018764-02l423mk	360	37	predictor	predictor	NOUN
cord-018764-02l423mk	360	38	of	of	ADP
cord-018764-02l423mk	360	39	anemia	anemia	NOUN
cord-018764-02l423mk	360	40	in	in	ADP
cord-018764-02l423mk	360	41	severe	severe	ADJ
cord-018764-02l423mk	360	42	falciparum	falciparum	NOUN
cord-018764-02l423mk	360	43	malaria	malaria	NOUN
cord-018764-02l423mk	360	44	bone	bone	NOUN
cord-018764-02l423mk	360	45	marrow	marrow	NOUN
cord-018764-02l423mk	360	46	changes	change	VERB
cord-018764-02l423mk	360	47	in	in	ADP
cord-018764-02l423mk	360	48	human	human	ADJ
cord-018764-02l423mk	360	49	malaria	malaria	NOUN
cord-018764-02l423mk	360	50	ineffective	ineffective	ADJ
cord-018764-02l423mk	360	51	erythropoiesis	erythropoiesis	NOUN
cord-018764-02l423mk	360	52	in	in	ADP
cord-018764-02l423mk	360	53	acute	acute	ADJ
cord-018764-02l423mk	360	54	human	human	ADJ
cord-018764-02l423mk	360	55	p.	p.	PROPN
cord-018764-02l423mk	360	56	falciparum	falciparum	NOUN
cord-018764-02l423mk	360	57	malaria	malaria	NOUN
cord-018764-02l423mk	360	58	the	the	DET
cord-018764-02l423mk	360	59	bone	bone	NOUN
cord-018764-02l423mk	360	60	marrow	marrow	NOUN
cord-018764-02l423mk	360	61	in	in	ADP
cord-018764-02l423mk	360	62	human	human	ADJ
cord-018764-02l423mk	360	63	cerebral	cerebral	ADJ
cord-018764-02l423mk	360	64	malaria	malaria	NOUN
cord-018764-02l423mk	360	65	:	:	PUNCT
cord-018764-02l423mk	360	66	parasite	parasite	ADJ
cord-018764-02l423mk	360	67	sequestration	sequestration	NOUN
cord-018764-02l423mk	360	68	within	within	ADP
cord-018764-02l423mk	360	69	sinusoids	sinusoid	NOUN
cord-018764-02l423mk	360	70	dyserythropoiesis	dyserythropoiesis	NOUN
cord-018764-02l423mk	360	71	and	and	CCONJ
cord-018764-02l423mk	360	72	ineffective	ineffective	ADJ
cord-018764-02l423mk	360	73	erythropoiesis	erythropoiesis	NOUN
cord-018764-02l423mk	360	74	in	in	ADP
cord-018764-02l423mk	360	75	plasmodium	plasmodium	PROPN
cord-018764-02l423mk	360	76	vivax	vivax	PROPN
cord-018764-02l423mk	360	77	malaria	malaria	PROPN
cord-018764-02l423mk	360	78	inhibiton	inhibiton	PROPN
cord-018764-02l423mk	360	79	of	of	ADP
cord-018764-02l423mk	360	80	the	the	DET
cord-018764-02l423mk	360	81	growth	growth	NOUN
cord-018764-02l423mk	360	82	and	and	CCONJ
cord-018764-02l423mk	360	83	differentiation	differentiation	NOUN
cord-018764-02l423mk	360	84	of	of	ADP
cord-018764-02l423mk	360	85	erythroid	erythroid	ADJ
cord-018764-02l423mk	360	86	precursor	precursor	NOUN
cord-018764-02l423mk	360	87	cells	cell	NOUN
cord-018764-02l423mk	360	88	by	by	ADP
cord-018764-02l423mk	360	89	an	an	DET
cord-018764-02l423mk	360	90	endotoxin	endotoxin	NOUN
cord-018764-02l423mk	360	91	-	-	PUNCT
cord-018764-02l423mk	360	92	induced	induce	VERB
cord-018764-02l423mk	360	93	mediator	mediator	NOUN
cord-018764-02l423mk	360	94	from	from	ADP
cord-018764-02l423mk	360	95	peritoneal	peritoneal	ADJ
cord-018764-02l423mk	360	96	macrophages	macrophage	NOUN
cord-018764-02l423mk	360	97	identity	identity	NOUN
cord-018764-02l423mk	360	98	of	of	ADP
cord-018764-02l423mk	360	99	tumour	tumour	NOUN
cord-018764-02l423mk	360	100	necrosis	necrosis	NOUN
cord-018764-02l423mk	360	101	factor	factor	NOUN
cord-018764-02l423mk	360	102	and	and	CCONJ
cord-018764-02l423mk	360	103	the	the	DET
cord-018764-02l423mk	360	104	macrophagesecreted	macrophagesecrete	VERB
cord-018764-02l423mk	360	105	factor	factor	NOUN
cord-018764-02l423mk	360	106	cachectin	cachectin	PROPN
cord-018764-02l423mk	360	107	tumour	tumour	PROPN
cord-018764-02l423mk	360	108	necrosis	necrosis	NOUN
cord-018764-02l423mk	360	109	factor	factor	NOUN
cord-018764-02l423mk	360	110	may	may	AUX
cord-018764-02l423mk	360	111	contribute	contribute	VERB
cord-018764-02l423mk	360	112	to	to	ADP
cord-018764-02l423mk	360	113	the	the	DET
cord-018764-02l423mk	360	114	anaemia	anaemia	NOUN
cord-018764-02l423mk	360	115	of	of	ADP
cord-018764-02l423mk	360	116	malaria	malaria	NOUN
cord-018764-02l423mk	360	117	by	by	ADP
cord-018764-02l423mk	360	118	causing	cause	VERB
cord-018764-02l423mk	360	119	dyserythropoiesis	dyserythropoiesis	NOUN
cord-018764-02l423mk	360	120	and	and	CCONJ
cord-018764-02l423mk	360	121	erythrophagocytosis	erythrophagocytosis	VERB
cord-018764-02l423mk	360	122	a	a	DET
cord-018764-02l423mk	360	123	low	low	ADJ
cord-018764-02l423mk	360	124	interleukin-10	interleukin-10	NUM
cord-018764-02l423mk	360	125	tumor	tumor	NOUN
cord-018764-02l423mk	360	126	necrosis	necrosis	NOUN
cord-018764-02l423mk	360	127	factor	factor	NOUN
cord-018764-02l423mk	360	128	-	-	PUNCT
cord-018764-02l423mk	360	129	alpha	alpha	NOUN
cord-018764-02l423mk	360	130	ratio	ratio	NOUN
cord-018764-02l423mk	360	131	is	be	AUX
cord-018764-02l423mk	360	132	associated	associate	VERB
cord-018764-02l423mk	360	133	with	with	ADP
cord-018764-02l423mk	360	134	malaria	malaria	NOUN
cord-018764-02l423mk	360	135	anemia	anemia	NOUN
cord-018764-02l423mk	360	136	in	in	ADP
cord-018764-02l423mk	360	137	children	child	NOUN
cord-018764-02l423mk	360	138	residing	reside	VERB
cord-018764-02l423mk	360	139	in	in	ADP
cord-018764-02l423mk	360	140	a	a	DET
cord-018764-02l423mk	360	141	holoendemic	holoendemic	ADJ
cord-018764-02l423mk	360	142	malaria	malaria	NOUN
cord-018764-02l423mk	360	143	region	region	NOUN
cord-018764-02l423mk	360	144	in	in	ADP
cord-018764-02l423mk	360	145	western	western	PROPN
cord-018764-02l423mk	360	146	kenya	kenya	PROPN
cord-018764-02l423mk	360	147	reduced	reduce	VERB
cord-018764-02l423mk	360	148	interleukin-12	interleukin-12	X
cord-018764-02l423mk	360	149	and	and	CCONJ
cord-018764-02l423mk	360	150	transforming	transform	VERB
cord-018764-02l423mk	360	151	growth	growth	NOUN
cord-018764-02l423mk	360	152	factor	factor	NOUN
cord-018764-02l423mk	360	153	-	-	PUNCT
cord-018764-02l423mk	360	154	beta1	beta1	NOUN
cord-018764-02l423mk	360	155	in	in	ADP
cord-018764-02l423mk	360	156	severe	severe	ADJ
cord-018764-02l423mk	360	157	childhood	childhood	NOUN
cord-018764-02l423mk	360	158	malaria	malaria	NOUN
cord-018764-02l423mk	360	159	:	:	PUNCT
cord-018764-02l423mk	360	160	relationship	relationship	NOUN
cord-018764-02l423mk	360	161	of	of	ADP
cord-018764-02l423mk	360	162	cytokine	cytokine	NOUN
cord-018764-02l423mk	360	163	balance	balance	NOUN
cord-018764-02l423mk	360	164	with	with	ADP
cord-018764-02l423mk	360	165	disease	disease	NOUN
cord-018764-02l423mk	360	166	severity	severity	NOUN
cord-018764-02l423mk	360	167	plasma	plasma	NOUN
cord-018764-02l423mk	360	168	interleukin-10	interleukin-10	PUNCT
cord-018764-02l423mk	360	169	:	:	PUNCT
cord-018764-02l423mk	360	170	tumor	tumor	NOUN
cord-018764-02l423mk	360	171	necrosis	necrosis	NOUN
cord-018764-02l423mk	360	172	factor	factor	NOUN
cord-018764-02l423mk	360	173	(	(	PUNCT
cord-018764-02l423mk	360	174	tnf)-alpha	tnf)-alpha	ADJ
cord-018764-02l423mk	360	175	ratio	ratio	NOUN
cord-018764-02l423mk	360	176	is	be	AUX
cord-018764-02l423mk	360	177	associated	associate	VERB
cord-018764-02l423mk	360	178	with	with	ADP
cord-018764-02l423mk	360	179	tnf	tnf	PROPN
cord-018764-02l423mk	360	180	promoter	promoter	NOUN
cord-018764-02l423mk	360	181	variants	variant	NOUN
cord-018764-02l423mk	360	182	and	and	CCONJ
cord-018764-02l423mk	360	183	predicts	predict	VERB
cord-018764-02l423mk	360	184	malarial	malarial	ADJ
cord-018764-02l423mk	360	185	complications	complication	NOUN
cord-018764-02l423mk	360	186	absolute	absolute	ADJ
cord-018764-02l423mk	360	187	levels	level	NOUN
cord-018764-02l423mk	360	188	and	and	CCONJ
cord-018764-02l423mk	360	189	ratios	ratio	NOUN
cord-018764-02l423mk	360	190	of	of	ADP
cord-018764-02l423mk	360	191	proinflammatory	proinflammatory	NOUN
cord-018764-02l423mk	360	192	and	and	CCONJ
cord-018764-02l423mk	360	193	anti	anti	ADJ
cord-018764-02l423mk	360	194	-	-	ADJ
cord-018764-02l423mk	360	195	inflammatory	inflammatory	ADJ
cord-018764-02l423mk	360	196	cytokine	cytokine	NOUN
cord-018764-02l423mk	360	197	production	production	NOUN
cord-018764-02l423mk	360	198	in	in	X
cord-018764-02l423mk	360	199	vitro	vitro	X
cord-018764-02l423mk	360	200	predict	predict	VERB
cord-018764-02l423mk	360	201	clinical	clinical	ADJ
cord-018764-02l423mk	360	202	immunity	immunity	NOUN
cord-018764-02l423mk	360	203	to	to	ADP
cord-018764-02l423mk	360	204	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	360	205	falciparum	falciparum	NOUN
cord-018764-02l423mk	360	206	malaria	malaria	NOUN
cord-018764-02l423mk	360	207	low	low	ADJ
cord-018764-02l423mk	360	208	interleukin-12	interleukin-12	PROPN
cord-018764-02l423mk	360	209	activity	activity	NOUN
cord-018764-02l423mk	360	210	in	in	ADP
cord-018764-02l423mk	360	211	severe	severe	ADJ
cord-018764-02l423mk	360	212	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	360	213	falciparum	falciparum	NOUN
cord-018764-02l423mk	360	214	malaria	malaria	NOUN
cord-018764-02l423mk	360	215	severe	severe	ADJ
cord-018764-02l423mk	360	216	malarial	malarial	ADJ
cord-018764-02l423mk	360	217	anemia	anemia	NOUN
cord-018764-02l423mk	360	218	associated	associate	VERB
cord-018764-02l423mk	360	219	with	with	ADP
cord-018764-02l423mk	360	220	increased	increase	VERB
cord-018764-02l423mk	360	221	soluble	soluble	ADJ
cord-018764-02l423mk	360	222	fas	fas	PROPN
cord-018764-02l423mk	360	223	ligand	ligand	NOUN
cord-018764-02l423mk	360	224	(	(	PUNCT
cord-018764-02l423mk	360	225	sfasl	sfasl	PROPN
cord-018764-02l423mk	360	226	)	)	PUNCT
cord-018764-02l423mk	360	227	concentrations	concentration	NOUN
cord-018764-02l423mk	360	228	in	in	ADP
cord-018764-02l423mk	360	229	gabonese	gabonese	ADJ
cord-018764-02l423mk	360	230	children	child	NOUN
cord-018764-02l423mk	360	231	bone	bone	NOUN
cord-018764-02l423mk	360	232	marrow	marrow	NOUN
cord-018764-02l423mk	360	233	suppression	suppression	NOUN
cord-018764-02l423mk	360	234	and	and	CCONJ
cord-018764-02l423mk	360	235	severe	severe	ADJ
cord-018764-02l423mk	360	236	anaemia	anaemia	NOUN
cord-018764-02l423mk	360	237	associated	associate	VERB
cord-018764-02l423mk	360	238	with	with	ADP
cord-018764-02l423mk	360	239	persistent	persistent	ADJ
cord-018764-02l423mk	360	240	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	360	241	falciparum	falciparum	NOUN
cord-018764-02l423mk	360	242	infection	infection	NOUN
cord-018764-02l423mk	360	243	in	in	ADP
cord-018764-02l423mk	360	244	african	african	ADJ
cord-018764-02l423mk	360	245	children	child	NOUN
cord-018764-02l423mk	360	246	with	with	ADP
cord-018764-02l423mk	360	247	microscopically	microscopically	ADV
cord-018764-02l423mk	360	248	undetectable	undetectable	ADJ
cord-018764-02l423mk	360	249	parasitaemia	parasitaemia	NOUN
cord-018764-02l423mk	360	250	macrophage	macrophage	NOUN
cord-018764-02l423mk	360	251	migration	migration	NOUN
cord-018764-02l423mk	360	252	inhibitory	inhibitory	ADJ
cord-018764-02l423mk	360	253	factor	factor	NOUN
cord-018764-02l423mk	360	254	release	release	NOUN
cord-018764-02l423mk	360	255	by	by	ADP
cord-018764-02l423mk	360	256	macrophages	macrophage	NOUN
cord-018764-02l423mk	360	257	after	after	ADP
cord-018764-02l423mk	360	258	ingestion	ingestion	NOUN
cord-018764-02l423mk	360	259	of	of	ADP
cord-018764-02l423mk	360	260	plasmodium	plasmodium	PROPN
cord-018764-02l423mk	360	261	chabaudi	chabaudi	ADJ
cord-018764-02l423mk	360	262	-	-	PUNCT
cord-018764-02l423mk	360	263	infected	infect	VERB
cord-018764-02l423mk	360	264	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	360	265	:	:	PUNCT
cord-018764-02l423mk	360	266	possible	possible	ADJ
cord-018764-02l423mk	360	267	role	role	NOUN
cord-018764-02l423mk	360	268	in	in	ADP
cord-018764-02l423mk	360	269	the	the	DET
cord-018764-02l423mk	360	270	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	360	271	of	of	ADP
cord-018764-02l423mk	360	272	malarial	malarial	ADJ
cord-018764-02l423mk	360	273	anemia	anemia	NOUN
cord-018764-02l423mk	360	274	a	a	DET
cord-018764-02l423mk	360	275	critical	critical	ADJ
cord-018764-02l423mk	360	276	role	role	NOUN
cord-018764-02l423mk	360	277	for	for	ADP
cord-018764-02l423mk	360	278	the	the	DET
cord-018764-02l423mk	360	279	host	host	NOUN
cord-018764-02l423mk	360	280	mediator	mediator	NOUN
cord-018764-02l423mk	360	281	macrophage	macrophage	NOUN
cord-018764-02l423mk	360	282	migration	migration	NOUN
cord-018764-02l423mk	360	283	inhibitory	inhibitory	ADJ
cord-018764-02l423mk	360	284	factor	factor	NOUN
cord-018764-02l423mk	360	285	in	in	ADP
cord-018764-02l423mk	360	286	the	the	DET
cord-018764-02l423mk	360	287	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	360	288	of	of	ADP
cord-018764-02l423mk	360	289	malarial	malarial	ADJ
cord-018764-02l423mk	360	290	anemia	anemia	NOUN
cord-018764-02l423mk	360	291	cytopathic	cytopathic	NOUN
cord-018764-02l423mk	360	292	hypoxia	hypoxia	NOUN
cord-018764-02l423mk	360	293	.	.	PUNCT
cord-018764-02l423mk	361	1	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	361	2	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	361	3	as	as	ADP
cord-018764-02l423mk	361	4	mechanism	mechanism	NOUN
cord-018764-02l423mk	361	5	contributing	contribute	VERB
cord-018764-02l423mk	361	6	to	to	ADP
cord-018764-02l423mk	361	7	organ	organ	VERB
cord-018764-02l423mk	361	8	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	361	9	in	in	ADP
cord-018764-02l423mk	361	10	sepsis	sepsis	NOUN
cord-018764-02l423mk	361	11	evaluation	evaluation	NOUN
cord-018764-02l423mk	361	12	of	of	ADP
cord-018764-02l423mk	361	13	the	the	DET
cord-018764-02l423mk	361	14	role	role	NOUN
cord-018764-02l423mk	361	15	of	of	ADP
cord-018764-02l423mk	361	16	cellular	cellular	ADJ
cord-018764-02l423mk	361	17	hypoxia	hypoxia	NOUN
cord-018764-02l423mk	361	18	in	in	ADP
cord-018764-02l423mk	361	19	sepsis	sepsis	NOUN
cord-018764-02l423mk	361	20	by	by	ADP
cord-018764-02l423mk	361	21	the	the	DET
cord-018764-02l423mk	361	22	hypoxic	hypoxic	NOUN
cord-018764-02l423mk	361	23	marker	marker	NOUN
cord-018764-02l423mk	361	24	[	[	PUNCT
cord-018764-02l423mk	361	25	18	18	NUM
cord-018764-02l423mk	361	26	f]fluoromisonidazole	f]fluoromisonidazole	NOUN
cord-018764-02l423mk	361	27	skeletal	skeletal	ADJ
cord-018764-02l423mk	361	28	muscle	muscle	NOUN
cord-018764-02l423mk	361	29	partial	partial	ADJ
cord-018764-02l423mk	361	30	pressure	pressure	NOUN
cord-018764-02l423mk	361	31	of	of	ADP
cord-018764-02l423mk	361	32	oxygen	oxygen	NOUN
cord-018764-02l423mk	361	33	in	in	ADP
cord-018764-02l423mk	361	34	patients	patient	NOUN
cord-018764-02l423mk	361	35	with	with	ADP
cord-018764-02l423mk	361	36	sepsis	sepsis	NOUN
cord-018764-02l423mk	361	37	cytopathic	cytopathic	ADJ
cord-018764-02l423mk	361	38	hypoxia	hypoxia	NOUN
cord-018764-02l423mk	361	39	in	in	ADP
cord-018764-02l423mk	361	40	sepsis	sepsis	NOUN
cord-018764-02l423mk	361	41	a	a	DET
cord-018764-02l423mk	361	42	global	global	ADJ
cord-018764-02l423mk	361	43	approach	approach	NOUN
cord-018764-02l423mk	361	44	to	to	ADP
cord-018764-02l423mk	361	45	energy	energy	NOUN
cord-018764-02l423mk	361	46	metabolism	metabolism	NOUN
cord-018764-02l423mk	361	47	in	in	ADP
cord-018764-02l423mk	361	48	an	an	DET
cord-018764-02l423mk	361	49	experimental	experimental	ADJ
cord-018764-02l423mk	361	50	model	model	NOUN
cord-018764-02l423mk	361	51	of	of	ADP
cord-018764-02l423mk	361	52	sepsis	sepsis	NOUN
cord-018764-02l423mk	361	53	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	361	54	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	361	55	in	in	ADP
cord-018764-02l423mk	361	56	a	a	DET
cord-018764-02l423mk	361	57	long	long	ADJ
cord-018764-02l423mk	361	58	-	-	PUNCT
cord-018764-02l423mk	361	59	term	term	NOUN
cord-018764-02l423mk	361	60	rodent	rodent	NOUN
cord-018764-02l423mk	361	61	model	model	NOUN
cord-018764-02l423mk	361	62	of	of	ADP
cord-018764-02l423mk	361	63	sepsis	sepsis	NOUN
cord-018764-02l423mk	361	64	and	and	CCONJ
cord-018764-02l423mk	361	65	organ	organ	NOUN
cord-018764-02l423mk	361	66	failure	failure	NOUN
cord-018764-02l423mk	361	67	association	association	NOUN
cord-018764-02l423mk	361	68	between	between	ADP
cord-018764-02l423mk	361	69	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	361	70	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	361	71	and	and	CCONJ
cord-018764-02l423mk	361	72	severity	severity	NOUN
cord-018764-02l423mk	361	73	and	and	CCONJ
cord-018764-02l423mk	361	74	outcome	outcome	NOUN
cord-018764-02l423mk	361	75	of	of	ADP
cord-018764-02l423mk	361	76	septic	septic	ADJ
cord-018764-02l423mk	361	77	shock	shock	NOUN
cord-018764-02l423mk	361	78	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	361	79	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	361	80	in	in	ADP
cord-018764-02l423mk	361	81	patients	patient	NOUN
cord-018764-02l423mk	361	82	with	with	ADP
cord-018764-02l423mk	361	83	severe	severe	ADJ
cord-018764-02l423mk	361	84	sepsis	sepsis	NOUN
cord-018764-02l423mk	361	85	:	:	PUNCT
cord-018764-02l423mk	361	86	an	an	DET
cord-018764-02l423mk	361	87	epr	epr	ADJ
cord-018764-02l423mk	361	88	interrogation	interrogation	NOUN
cord-018764-02l423mk	361	89	of	of	ADP
cord-018764-02l423mk	361	90	individual	individual	ADJ
cord-018764-02l423mk	361	91	respiratory	respiratory	ADJ
cord-018764-02l423mk	361	92	chain	chain	NOUN
cord-018764-02l423mk	361	93	components	component	NOUN
cord-018764-02l423mk	361	94	elevated	elevate	VERB
cord-018764-02l423mk	361	95	tumour	tumour	NOUN
cord-018764-02l423mk	361	96	necrosis	necrosis	NOUN
cord-018764-02l423mk	361	97	factor	factor	NOUN
cord-018764-02l423mk	361	98	alpha	alpha	NOUN
cord-018764-02l423mk	361	99	and	and	CCONJ
cord-018764-02l423mk	361	100	interleukin-6	interleukin-6	VERB
cord-018764-02l423mk	361	101	serum	serum	NOUN
cord-018764-02l423mk	361	102	levels	level	NOUN
cord-018764-02l423mk	361	103	as	as	ADP
cord-018764-02l423mk	361	104	markers	marker	NOUN
cord-018764-02l423mk	361	105	for	for	ADP
cord-018764-02l423mk	361	106	complicated	complicated	ADJ
cord-018764-02l423mk	361	107	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	361	108	falciparum	falciparum	NOUN
cord-018764-02l423mk	361	109	malaria	malaria	NOUN
cord-018764-02l423mk	361	110	tnf	tnf	PROPN
cord-018764-02l423mk	361	111	concentration	concentration	NOUN
cord-018764-02l423mk	361	112	in	in	ADP
cord-018764-02l423mk	361	113	fatal	fatal	ADJ
cord-018764-02l423mk	361	114	cerebral	cerebral	ADJ
cord-018764-02l423mk	361	115	,	,	PUNCT
cord-018764-02l423mk	361	116	non	non	ADJ
cord-018764-02l423mk	361	117	-	-	ADJ
cord-018764-02l423mk	361	118	fatal	fatal	ADJ
cord-018764-02l423mk	361	119	cerebral	cerebral	NOUN
cord-018764-02l423mk	361	120	,	,	PUNCT
cord-018764-02l423mk	361	121	and	and	CCONJ
cord-018764-02l423mk	361	122	uncomplicated	uncomplicated	ADJ
cord-018764-02l423mk	361	123	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	361	124	falciparum	falciparum	NOUN
cord-018764-02l423mk	361	125	malaria	malaria	NOUN
cord-018764-02l423mk	361	126	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	361	127	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	361	128	and	and	CCONJ
cord-018764-02l423mk	361	129	glutamate	glutamate	NOUN
cord-018764-02l423mk	361	130	excitotoxicity	excitotoxicity	NOUN
cord-018764-02l423mk	361	131	studied	study	VERB
cord-018764-02l423mk	361	132	in	in	ADP
cord-018764-02l423mk	361	133	primary	primary	ADJ
cord-018764-02l423mk	361	134	neuronal	neuronal	ADJ
cord-018764-02l423mk	361	135	cultures	culture	NOUN
cord-018764-02l423mk	361	136	a	a	DET
cord-018764-02l423mk	361	137	factor	factor	NOUN
cord-018764-02l423mk	361	138	in	in	ADP
cord-018764-02l423mk	361	139	the	the	DET
cord-018764-02l423mk	361	140	serum	serum	NOUN
cord-018764-02l423mk	361	141	of	of	ADP
cord-018764-02l423mk	361	142	malaria	malaria	NOUN
cord-018764-02l423mk	361	143	-	-	PUNCT
cord-018764-02l423mk	361	144	infected	infect	VERB
cord-018764-02l423mk	361	145	animals	animal	NOUN
cord-018764-02l423mk	361	146	capable	capable	ADJ
cord-018764-02l423mk	361	147	of	of	ADP
cord-018764-02l423mk	361	148	inhibiting	inhibit	VERB
cord-018764-02l423mk	361	149	the	the	DET
cord-018764-02l423mk	361	150	in	in	X
cord-018764-02l423mk	361	151	vitro	vitro	X
cord-018764-02l423mk	361	152	oxidative	oxidative	ADJ
cord-018764-02l423mk	361	153	metabolism	metabolism	NOUN
cord-018764-02l423mk	361	154	of	of	ADP
cord-018764-02l423mk	361	155	normal	normal	ADJ
cord-018764-02l423mk	361	156	liver	liver	NOUN
cord-018764-02l423mk	361	157	mitochondria	mitochondria	NOUN
cord-018764-02l423mk	361	158	the	the	DET
cord-018764-02l423mk	361	159	inhibition	inhibition	NOUN
cord-018764-02l423mk	361	160	of	of	ADP
cord-018764-02l423mk	361	161	mitochondrial	mitochondrial	ADJ
cord-018764-02l423mk	361	162	respiration	respiration	NOUN
cord-018764-02l423mk	361	163	and	and	CCONJ
cord-018764-02l423mk	361	164	oxidative	oxidative	ADJ
cord-018764-02l423mk	361	165	phosphorylation	phosphorylation	NOUN
cord-018764-02l423mk	361	166	by	by	ADP
cord-018764-02l423mk	361	167	serum	serum	NOUN
cord-018764-02l423mk	361	168	from	from	ADP
cord-018764-02l423mk	361	169	malaria	malaria	NOUN
cord-018764-02l423mk	361	170	-	-	PUNCT
cord-018764-02l423mk	361	171	infected	infect	VERB
cord-018764-02l423mk	361	172	animals	animal	NOUN
cord-018764-02l423mk	361	173	.	.	PUNCT
cord-018764-02l423mk	362	1	ii	ii	PROPN
cord-018764-02l423mk	362	2	.	.	PUNCT
cord-018764-02l423mk	363	1	the	the	DET
cord-018764-02l423mk	363	2	inhibitory	inhibitory	ADJ
cord-018764-02l423mk	363	3	activity	activity	NOUN
cord-018764-02l423mk	363	4	of	of	ADP
cord-018764-02l423mk	363	5	serum	serum	NOUN
cord-018764-02l423mk	363	6	ultrafitrates	ultrafitrate	NOUN
cord-018764-02l423mk	363	7	from	from	ADP
cord-018764-02l423mk	363	8	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	363	9	knowlesi	knowlesi	NOUN
cord-018764-02l423mk	363	10	-	-	PUNCT
cord-018764-02l423mk	363	11	infected	infect	VERB
cord-018764-02l423mk	363	12	monkeys	monkey	NOUN
cord-018764-02l423mk	363	13	the	the	DET
cord-018764-02l423mk	363	14	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	363	15	of	of	ADP
cord-018764-02l423mk	363	16	mammalian	mammalian	ADJ
cord-018764-02l423mk	363	17	malaria	malaria	NOUN
cord-018764-02l423mk	363	18	acid	acid	ADJ
cord-018764-02l423mk	363	19	-	-	PUNCT
cord-018764-02l423mk	363	20	base	base	NOUN
cord-018764-02l423mk	363	21	status	status	NOUN
cord-018764-02l423mk	363	22	in	in	ADP
cord-018764-02l423mk	363	23	paediatric	paediatric	ADJ
cord-018764-02l423mk	363	24	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	363	25	falciparum	falciparum	NOUN
cord-018764-02l423mk	363	26	malaria	malaria	NOUN
cord-018764-02l423mk	363	27	lactic	lactic	ADJ
cord-018764-02l423mk	363	28	acidosis	acidosis	NOUN
cord-018764-02l423mk	363	29	and	and	CCONJ
cord-018764-02l423mk	363	30	hypoglycaemia	hypoglycaemia	NOUN
cord-018764-02l423mk	363	31	in	in	ADP
cord-018764-02l423mk	363	32	children	child	NOUN
cord-018764-02l423mk	363	33	with	with	ADP
cord-018764-02l423mk	363	34	severe	severe	ADJ
cord-018764-02l423mk	363	35	malaria	malaria	NOUN
cord-018764-02l423mk	363	36	-pathophysiological	-pathophysiological	ADJ
cord-018764-02l423mk	363	37	and	and	CCONJ
cord-018764-02l423mk	363	38	prognostic	prognostic	ADJ
cord-018764-02l423mk	363	39	significance	significance	NOUN
cord-018764-02l423mk	363	40	the	the	DET
cord-018764-02l423mk	363	41	significance	significance	NOUN
cord-018764-02l423mk	363	42	of	of	ADP
cord-018764-02l423mk	363	43	type	type	PROPN
cord-018764-02l423mk	363	44	b	b	PROPN
cord-018764-02l423mk	363	45	hyperlactataemia	hyperlactataemia	PROPN
cord-018764-02l423mk	363	46	in	in	ADP
cord-018764-02l423mk	363	47	infective	infective	ADJ
cord-018764-02l423mk	363	48	encephalopathy	encephalopathy	ADJ
cord-018764-02l423mk	363	49	characterisation	characterisation	NOUN
cord-018764-02l423mk	363	50	of	of	ADP
cord-018764-02l423mk	363	51	metabolic	metabolic	ADJ
cord-018764-02l423mk	363	52	acidosis	acidosis	NOUN
cord-018764-02l423mk	363	53	in	in	ADP
cord-018764-02l423mk	363	54	kenyan	kenyan	ADJ
cord-018764-02l423mk	363	55	children	child	NOUN
cord-018764-02l423mk	363	56	admitted	admit	VERB
cord-018764-02l423mk	363	57	to	to	ADP
cord-018764-02l423mk	363	58	hospital	hospital	NOUN
cord-018764-02l423mk	363	59	for	for	ADP
cord-018764-02l423mk	363	60	acute	acute	ADJ
cord-018764-02l423mk	363	61	non	non	ADJ
cord-018764-02l423mk	363	62	-	-	ADJ
cord-018764-02l423mk	363	63	surgical	surgical	ADJ
cord-018764-02l423mk	363	64	conditions	condition	NOUN
cord-018764-02l423mk	363	65	protons	proton	NOUN
cord-018764-02l423mk	363	66	in	in	ADP
cord-018764-02l423mk	363	67	ischemia	ischemia	NOUN
cord-018764-02l423mk	363	68	:	:	PUNCT
cord-018764-02l423mk	363	69	where	where	SCONJ
cord-018764-02l423mk	363	70	do	do	AUX
cord-018764-02l423mk	363	71	they	they	PRON
cord-018764-02l423mk	363	72	come	come	VERB
cord-018764-02l423mk	363	73	from	from	ADP
cord-018764-02l423mk	363	74	;	;	PUNCT
cord-018764-02l423mk	363	75	where	where	SCONJ
cord-018764-02l423mk	363	76	do	do	AUX
cord-018764-02l423mk	363	77	they	they	PRON
cord-018764-02l423mk	363	78	go	go	VERB
cord-018764-02l423mk	363	79	to	to	ADP
cord-018764-02l423mk	363	80	?	?	PUNCT
cord-018764-02l423mk	364	1	reevaluation	reevaluation	NOUN
cord-018764-02l423mk	364	2	of	of	ADP
cord-018764-02l423mk	364	3	the	the	DET
cord-018764-02l423mk	364	4	role	role	NOUN
cord-018764-02l423mk	364	5	of	of	ADP
cord-018764-02l423mk	364	6	cellular	cellular	ADJ
cord-018764-02l423mk	364	7	hypoxia	hypoxia	NOUN
cord-018764-02l423mk	364	8	and	and	CCONJ
cord-018764-02l423mk	364	9	bioenergetic	bioenergetic	ADJ
cord-018764-02l423mk	364	10	failure	failure	NOUN
cord-018764-02l423mk	364	11	in	in	ADP
cord-018764-02l423mk	364	12	sepsis	sepsis	NOUN
cord-018764-02l423mk	364	13	does	do	AUX
cord-018764-02l423mk	364	14	tissue	tissue	VERB
cord-018764-02l423mk	364	15	acidosis	acidosis	NOUN
cord-018764-02l423mk	364	16	in	in	ADP
cord-018764-02l423mk	364	17	sepsis	sepsis	NOUN
cord-018764-02l423mk	364	18	indicate	indicate	VERB
cord-018764-02l423mk	364	19	tissue	tissue	NOUN
cord-018764-02l423mk	364	20	hypoperfusion	hypoperfusion	NOUN
cord-018764-02l423mk	364	21	?	?	PUNCT
cord-018764-02l423mk	365	1	association	association	NOUN
cord-018764-02l423mk	365	2	between	between	ADP
cord-018764-02l423mk	365	3	blood	blood	NOUN
cord-018764-02l423mk	365	4	lactate	lactate	NOUN
cord-018764-02l423mk	365	5	and	and	CCONJ
cord-018764-02l423mk	365	6	acidbase	acidbase	ADJ
cord-018764-02l423mk	365	7	status	status	NOUN
cord-018764-02l423mk	365	8	and	and	CCONJ
cord-018764-02l423mk	365	9	mortality	mortality	NOUN
cord-018764-02l423mk	365	10	in	in	ADP
cord-018764-02l423mk	365	11	ventilated	ventilate	VERB
cord-018764-02l423mk	365	12	babies	baby	NOUN
cord-018764-02l423mk	365	13	ultimate	ultimate	ADJ
cord-018764-02l423mk	365	14	survival	survival	NOUN
cord-018764-02l423mk	365	15	from	from	ADP
cord-018764-02l423mk	365	16	septic	septic	ADJ
cord-018764-02l423mk	365	17	shock	shock	NOUN
cord-018764-02l423mk	365	18	severe	severe	ADJ
cord-018764-02l423mk	365	19	hypoglycemia	hypoglycemia	NOUN
cord-018764-02l423mk	365	20	and	and	CCONJ
cord-018764-02l423mk	365	21	hyperinsulinemia	hyperinsulinemia	NOUN
cord-018764-02l423mk	365	22	in	in	ADP
cord-018764-02l423mk	365	23	falciparum	falciparum	PROPN
cord-018764-02l423mk	365	24	malaria	malaria	NOUN
cord-018764-02l423mk	365	25	malaria	malaria	NOUN
cord-018764-02l423mk	365	26	and	and	CCONJ
cord-018764-02l423mk	365	27	fluids	fluid	NOUN
cord-018764-02l423mk	365	28	-balancing	-balance	VERB
cord-018764-02l423mk	365	29	acts	act	VERB
cord-018764-02l423mk	365	30	thiamine	thiamine	NOUN
cord-018764-02l423mk	365	31	deficiency	deficiency	NOUN
cord-018764-02l423mk	365	32	and	and	CCONJ
cord-018764-02l423mk	365	33	malaria	malaria	NOUN
cord-018764-02l423mk	365	34	in	in	ADP
cord-018764-02l423mk	365	35	adults	adult	NOUN
cord-018764-02l423mk	365	36	from	from	ADP
cord-018764-02l423mk	365	37	southeast	southeast	PROPN
cord-018764-02l423mk	365	38	asia	asia	PROPN
cord-018764-02l423mk	365	39	lactate	lactate	PROPN
cord-018764-02l423mk	365	40	homeostasis	homeostasis	PROPN
cord-018764-02l423mk	365	41	and	and	CCONJ
cord-018764-02l423mk	365	42	lactic	lactic	ADJ
cord-018764-02l423mk	365	43	acidosis	acidosis	NOUN
cord-018764-02l423mk	365	44	lactic	lactic	ADJ
cord-018764-02l423mk	365	45	acidosis	acidosis	NOUN
cord-018764-02l423mk	365	46	in	in	ADP
cord-018764-02l423mk	365	47	sepsis	sepsis	NOUN
cord-018764-02l423mk	365	48	:	:	PUNCT
cord-018764-02l423mk	365	49	another	another	DET
cord-018764-02l423mk	365	50	commentary	commentary	NOUN
cord-018764-02l423mk	365	51	dichloroacetate	dichloroacetate	NOUN
cord-018764-02l423mk	365	52	for	for	ADP
cord-018764-02l423mk	365	53	lactic	lactic	ADJ
cord-018764-02l423mk	365	54	acidosis	acidosis	NOUN
cord-018764-02l423mk	365	55	in	in	ADP
cord-018764-02l423mk	365	56	severe	severe	ADJ
cord-018764-02l423mk	365	57	malaria	malaria	NOUN
cord-018764-02l423mk	365	58	:	:	PUNCT
cord-018764-02l423mk	365	59	a	a	DET
cord-018764-02l423mk	365	60	pharmacokinetic	pharmacokinetic	ADJ
cord-018764-02l423mk	365	61	and	and	CCONJ
cord-018764-02l423mk	365	62	pharmacodynamic	pharmacodynamic	ADJ
cord-018764-02l423mk	365	63	assessment	assessment	NOUN
cord-018764-02l423mk	365	64	a	a	DET
cord-018764-02l423mk	365	65	controlled	control	VERB
cord-018764-02l423mk	365	66	clinical	clinical	ADJ
cord-018764-02l423mk	365	67	trial	trial	NOUN
cord-018764-02l423mk	365	68	of	of	ADP
cord-018764-02l423mk	365	69	dichloroacetate	dichloroacetate	NOUN
cord-018764-02l423mk	365	70	for	for	ADP
cord-018764-02l423mk	365	71	treatment	treatment	NOUN
cord-018764-02l423mk	365	72	of	of	ADP
cord-018764-02l423mk	365	73	lactic	lactic	ADJ
cord-018764-02l423mk	365	74	acidosis	acidosis	NOUN
cord-018764-02l423mk	365	75	in	in	ADP
cord-018764-02l423mk	365	76	adults	adult	NOUN
cord-018764-02l423mk	365	77	protection	protection	NOUN
cord-018764-02l423mk	365	78	by	by	ADP
cord-018764-02l423mk	365	79	lactate	lactate	NOUN
cord-018764-02l423mk	365	80	of	of	ADP
cord-018764-02l423mk	365	81	cerebral	cerebral	ADJ
cord-018764-02l423mk	365	82	function	function	NOUN
cord-018764-02l423mk	365	83	during	during	ADP
cord-018764-02l423mk	365	84	hypoglycaemia	hypoglycaemia	NOUN
cord-018764-02l423mk	365	85	brain	brain	NOUN
cord-018764-02l423mk	365	86	lactate	lactate	NOUN
cord-018764-02l423mk	365	87	,	,	PUNCT
cord-018764-02l423mk	365	88	not	not	PART
cord-018764-02l423mk	365	89	glucose	glucose	NOUN
cord-018764-02l423mk	365	90	,	,	PUNCT
cord-018764-02l423mk	365	91	fuels	fuel	VERB
cord-018764-02l423mk	365	92	the	the	DET
cord-018764-02l423mk	365	93	recovery	recovery	NOUN
cord-018764-02l423mk	365	94	of	of	ADP
cord-018764-02l423mk	365	95	synaptic	synaptic	NOUN
cord-018764-02l423mk	365	96	function	function	NOUN
cord-018764-02l423mk	365	97	from	from	ADP
cord-018764-02l423mk	365	98	hypoxia	hypoxia	NOUN
cord-018764-02l423mk	365	99	upon	upon	SCONJ
cord-018764-02l423mk	365	100	reoxygenation	reoxygenation	NOUN
cord-018764-02l423mk	365	101	:	:	PUNCT
cord-018764-02l423mk	365	102	an	an	DET
cord-018764-02l423mk	365	103	in	in	X
cord-018764-02l423mk	365	104	vitro	vitro	X
cord-018764-02l423mk	365	105	study	study	VERB
cord-018764-02l423mk	365	106	the	the	DET
cord-018764-02l423mk	365	107	effect	effect	NOUN
cord-018764-02l423mk	365	108	of	of	ADP
cord-018764-02l423mk	365	109	intravenous	intravenous	ADJ
cord-018764-02l423mk	365	110	lactate	lactate	NOUN
cord-018764-02l423mk	365	111	on	on	ADP
cord-018764-02l423mk	365	112	cerebral	cerebral	ADJ
cord-018764-02l423mk	365	113	function	function	NOUN
cord-018764-02l423mk	365	114	during	during	ADP
cord-018764-02l423mk	365	115	hypoglycaemia	hypoglycaemia	NOUN
cord-018764-02l423mk	365	116	lactate	lactate	NOUN
cord-018764-02l423mk	365	117	as	as	ADP
cord-018764-02l423mk	365	118	a	a	DET
cord-018764-02l423mk	365	119	pivotal	pivotal	ADJ
cord-018764-02l423mk	365	120	element	element	NOUN
cord-018764-02l423mk	365	121	in	in	ADP
cord-018764-02l423mk	365	122	neuron	neuron	NOUN
cord-018764-02l423mk	365	123	-	-	PUNCT
cord-018764-02l423mk	365	124	glia	glia	NOUN
cord-018764-02l423mk	365	125	metabolic	metabolic	ADJ
cord-018764-02l423mk	365	126	cooperation	cooperation	NOUN
cord-018764-02l423mk	365	127	unaccounted	unaccounted	ADJ
cord-018764-02l423mk	365	128	for	for	ADP
cord-018764-02l423mk	365	129	anion	anion	NOUN
cord-018764-02l423mk	365	130	in	in	ADP
cord-018764-02l423mk	365	131	metabolic	metabolic	ADJ
cord-018764-02l423mk	365	132	acidosis	acidosis	NOUN
cord-018764-02l423mk	365	133	during	during	ADP
cord-018764-02l423mk	365	134	severe	severe	ADJ
cord-018764-02l423mk	365	135	sepsis	sepsis	NOUN
cord-018764-02l423mk	365	136	in	in	ADP
cord-018764-02l423mk	365	137	humans	human	NOUN
cord-018764-02l423mk	365	138	unmeasured	unmeasure	VERB
cord-018764-02l423mk	365	139	anions	anion	NOUN
cord-018764-02l423mk	365	140	identified	identify	VERB
cord-018764-02l423mk	365	141	by	by	ADP
cord-018764-02l423mk	365	142	the	the	DET
cord-018764-02l423mk	365	143	fencl	fencl	NOUN
cord-018764-02l423mk	365	144	-	-	PUNCT
cord-018764-02l423mk	365	145	stewart	stewart	PROPN
cord-018764-02l423mk	365	146	method	method	NOUN
cord-018764-02l423mk	365	147	predict	predict	VERB
cord-018764-02l423mk	365	148	mortality	mortality	NOUN
cord-018764-02l423mk	365	149	better	well	ADV
cord-018764-02l423mk	365	150	than	than	ADP
cord-018764-02l423mk	365	151	base	base	ADJ
cord-018764-02l423mk	365	152	excess	excess	NOUN
cord-018764-02l423mk	365	153	,	,	PUNCT
cord-018764-02l423mk	365	154	anion	anion	NOUN
cord-018764-02l423mk	365	155	gap	gap	NOUN
cord-018764-02l423mk	365	156	,	,	PUNCT
cord-018764-02l423mk	365	157	and	and	CCONJ
cord-018764-02l423mk	365	158	lactate	lactate	NOUN
cord-018764-02l423mk	365	159	in	in	ADP
cord-018764-02l423mk	365	160	patients	patient	NOUN
cord-018764-02l423mk	365	161	in	in	ADP
cord-018764-02l423mk	365	162	the	the	DET
cord-018764-02l423mk	365	163	pediatric	pediatric	ADJ
cord-018764-02l423mk	365	164	intensive	intensive	ADJ
cord-018764-02l423mk	365	165	care	care	NOUN
cord-018764-02l423mk	365	166	unit	unit	NOUN
cord-018764-02l423mk	365	167	unidentified	unidentified	ADJ
cord-018764-02l423mk	365	168	acids	acid	NOUN
cord-018764-02l423mk	365	169	of	of	ADP
cord-018764-02l423mk	365	170	strong	strong	ADJ
cord-018764-02l423mk	365	171	prognostic	prognostic	ADJ
cord-018764-02l423mk	365	172	significance	significance	NOUN
cord-018764-02l423mk	365	173	in	in	ADP
cord-018764-02l423mk	365	174	severe	severe	ADJ
cord-018764-02l423mk	365	175	malaria	malaria	NOUN
cord-018764-02l423mk	365	176	glucose	glucose	NOUN
cord-018764-02l423mk	365	177	homeostasis	homeostasis	NOUN
cord-018764-02l423mk	365	178	in	in	ADP
cord-018764-02l423mk	365	179	children	child	NOUN
cord-018764-02l423mk	365	180	with	with	ADP
cord-018764-02l423mk	365	181	falciparum	falciparum	NOUN
cord-018764-02l423mk	365	182	malaria	malaria	NOUN
cord-018764-02l423mk	365	183	:	:	PUNCT
cord-018764-02l423mk	365	184	precursor	precursor	NOUN
cord-018764-02l423mk	365	185	supply	supply	NOUN
cord-018764-02l423mk	365	186	limits	limit	VERB
cord-018764-02l423mk	365	187	gluconeogenesis	gluconeogenesis	NOUN
cord-018764-02l423mk	365	188	and	and	CCONJ
cord-018764-02l423mk	365	189	glucose	glucose	NOUN
cord-018764-02l423mk	365	190	production	production	NOUN
cord-018764-02l423mk	365	191	hypoglycemia	hypoglycemia	NOUN
cord-018764-02l423mk	365	192	as	as	ADP
cord-018764-02l423mk	365	193	a	a	DET
cord-018764-02l423mk	365	194	manifestation	manifestation	NOUN
cord-018764-02l423mk	365	195	of	of	ADP
cord-018764-02l423mk	365	196	sepsis	sepsis	NOUN
cord-018764-02l423mk	365	197	hypoglycaemia	hypoglycaemia	NOUN
cord-018764-02l423mk	365	198	is	be	AUX
cord-018764-02l423mk	365	199	an	an	DET
cord-018764-02l423mk	365	200	important	important	ADJ
cord-018764-02l423mk	365	201	complication	complication	NOUN
cord-018764-02l423mk	365	202	of	of	ADP
cord-018764-02l423mk	365	203	falciparum	falciparum	NOUN
cord-018764-02l423mk	365	204	malaria	malaria	NOUN
cord-018764-02l423mk	365	205	severe	severe	ADJ
cord-018764-02l423mk	365	206	falciparum	falciparum	NOUN
cord-018764-02l423mk	365	207	malaria	malaria	NOUN
cord-018764-02l423mk	365	208	intracranial	intracranial	ADJ
cord-018764-02l423mk	365	209	pressure	pressure	NOUN
cord-018764-02l423mk	365	210	in	in	ADP
cord-018764-02l423mk	365	211	childhood	childhood	NOUN
cord-018764-02l423mk	365	212	cerebral	cerebral	ADJ
cord-018764-02l423mk	365	213	malaria	malaria	NOUN
cord-018764-02l423mk	365	214	intracranial	intracranial	ADJ
cord-018764-02l423mk	365	215	hypertension	hypertension	NOUN
cord-018764-02l423mk	365	216	in	in	ADP
cord-018764-02l423mk	365	217	africans	africans	PROPN
cord-018764-02l423mk	365	218	with	with	ADP
cord-018764-02l423mk	365	219	cerebral	cerebral	ADJ
cord-018764-02l423mk	365	220	malaria	malaria	NOUN
cord-018764-02l423mk	365	221	prognostic	prognostic	ADJ
cord-018764-02l423mk	365	222	significance	significance	NOUN
cord-018764-02l423mk	365	223	and	and	CCONJ
cord-018764-02l423mk	365	224	course	course	NOUN
cord-018764-02l423mk	365	225	of	of	ADP
cord-018764-02l423mk	365	226	retinopathy	retinopathy	NOUN
cord-018764-02l423mk	365	227	in	in	ADP
cord-018764-02l423mk	365	228	children	child	NOUN
cord-018764-02l423mk	365	229	with	with	ADP
cord-018764-02l423mk	365	230	severe	severe	ADJ
cord-018764-02l423mk	365	231	malaria	malaria	NOUN
cord-018764-02l423mk	365	232	blood	blood	NOUN
cord-018764-02l423mk	365	233	-	-	PUNCT
cord-018764-02l423mk	365	234	brain	brain	NOUN
cord-018764-02l423mk	365	235	barrier	barrier	NOUN
cord-018764-02l423mk	365	236	in	in	ADP
cord-018764-02l423mk	365	237	falciparum	falciparum	NOUN
cord-018764-02l423mk	365	238	malaria	malaria	NOUN
cord-018764-02l423mk	365	239	breaking	break	VERB
cord-018764-02l423mk	365	240	down	down	ADP
cord-018764-02l423mk	365	241	the	the	DET
cord-018764-02l423mk	365	242	blood	blood	NOUN
cord-018764-02l423mk	365	243	-	-	PUNCT
cord-018764-02l423mk	365	244	brain	brain	NOUN
cord-018764-02l423mk	365	245	barrier	barrier	NOUN
cord-018764-02l423mk	365	246	:	:	PUNCT
cord-018764-02l423mk	365	247	signaling	signal	VERB
cord-018764-02l423mk	365	248	a	a	DET
cord-018764-02l423mk	365	249	path	path	NOUN
cord-018764-02l423mk	365	250	to	to	ADP
cord-018764-02l423mk	365	251	cerebral	cerebral	ADJ
cord-018764-02l423mk	365	252	malaria	malaria	NOUN
cord-018764-02l423mk	365	253	?	?	PUNCT
cord-018764-02l423mk	366	1	evidence	evidence	NOUN
cord-018764-02l423mk	366	2	of	of	ADP
cord-018764-02l423mk	366	3	blood	blood	NOUN
cord-018764-02l423mk	366	4	-	-	PUNCT
cord-018764-02l423mk	366	5	brain	brain	NOUN
cord-018764-02l423mk	366	6	barrier	barrier	NOUN
cord-018764-02l423mk	366	7	dysfunction	dysfunction	NOUN
cord-018764-02l423mk	366	8	in	in	ADP
cord-018764-02l423mk	366	9	human	human	ADJ
cord-018764-02l423mk	366	10	cerebral	cerebral	ADJ
cord-018764-02l423mk	366	11	malaria	malaria	NOUN
cord-018764-02l423mk	366	12	function	function	NOUN
cord-018764-02l423mk	366	13	of	of	ADP
cord-018764-02l423mk	366	14	the	the	DET
cord-018764-02l423mk	366	15	blood	blood	NOUN
cord-018764-02l423mk	366	16	-	-	PUNCT
cord-018764-02l423mk	366	17	cerebrospinal	cerebrospinal	ADJ
cord-018764-02l423mk	366	18	fluid	fluid	NOUN
cord-018764-02l423mk	366	19	barrier	barrier	NOUN
cord-018764-02l423mk	366	20	in	in	ADP
cord-018764-02l423mk	366	21	human	human	ADJ
cord-018764-02l423mk	366	22	cerebral	cerebral	ADJ
cord-018764-02l423mk	366	23	malaria	malaria	NOUN
cord-018764-02l423mk	366	24	:	:	PUNCT
cord-018764-02l423mk	366	25	rejection	rejection	NOUN
cord-018764-02l423mk	366	26	of	of	ADP
cord-018764-02l423mk	366	27	the	the	DET
cord-018764-02l423mk	366	28	permeability	permeability	NOUN
cord-018764-02l423mk	366	29	hypothesis	hypothesis	NOUN
cord-018764-02l423mk	366	30	blood	blood	NOUN
cord-018764-02l423mk	366	31	-	-	PUNCT
cord-018764-02l423mk	366	32	brain	brain	NOUN
cord-018764-02l423mk	366	33	barrier	barrier	NOUN
cord-018764-02l423mk	366	34	function	function	NOUN
cord-018764-02l423mk	366	35	in	in	ADP
cord-018764-02l423mk	366	36	cerebral	cerebral	ADJ
cord-018764-02l423mk	366	37	malaria	malaria	NOUN
cord-018764-02l423mk	366	38	and	and	CCONJ
cord-018764-02l423mk	366	39	cns	cns	PROPN
cord-018764-02l423mk	366	40	infections	infection	NOUN
cord-018764-02l423mk	366	41	in	in	ADP
cord-018764-02l423mk	366	42	vietnam	vietnam	PROPN
cord-018764-02l423mk	366	43	edema	edema	NOUN
cord-018764-02l423mk	366	44	and	and	CCONJ
cord-018764-02l423mk	366	45	brain	brain	NOUN
cord-018764-02l423mk	366	46	trauma	trauma	NOUN
cord-018764-02l423mk	366	47	clinical	clinical	ADJ
cord-018764-02l423mk	366	48	manifestations	manifestation	NOUN
cord-018764-02l423mk	366	49	of	of	ADP
cord-018764-02l423mk	366	50	severe	severe	ADJ
cord-018764-02l423mk	366	51	malaria	malaria	NOUN
cord-018764-02l423mk	366	52	in	in	ADP
cord-018764-02l423mk	366	53	the	the	DET
cord-018764-02l423mk	366	54	highlands	highland	NOUN
cord-018764-02l423mk	366	55	of	of	ADP
cord-018764-02l423mk	366	56	southwestern	southwestern	ADJ
cord-018764-02l423mk	366	57	uganda	uganda	PROPN
cord-018764-02l423mk	366	58	malaria	malaria	NOUN
cord-018764-02l423mk	366	59	:	:	PUNCT
cord-018764-02l423mk	366	60	pathogenicity	pathogenicity	NOUN
cord-018764-02l423mk	366	61	and	and	CCONJ
cord-018764-02l423mk	366	62	disease	disease	NOUN
cord-018764-02l423mk	366	63	outcome	outcome	NOUN
cord-018764-02l423mk	366	64	of	of	ADP
cord-018764-02l423mk	366	65	stroke	stroke	NOUN
cord-018764-02l423mk	366	66	in	in	ADP
cord-018764-02l423mk	366	67	saudi	saudi	ADJ
cord-018764-02l423mk	366	68	children	child	NOUN
cord-018764-02l423mk	366	69	brain	brain	NOUN
cord-018764-02l423mk	366	70	swelling	swelling	NOUN
cord-018764-02l423mk	366	71	and	and	CCONJ
cord-018764-02l423mk	366	72	ischaemia	ischaemia	NOUN
cord-018764-02l423mk	366	73	in	in	ADP
cord-018764-02l423mk	366	74	kenyans	kenyans	PROPN
cord-018764-02l423mk	366	75	with	with	ADP
cord-018764-02l423mk	366	76	cerebral	cerebral	ADJ
cord-018764-02l423mk	366	77	malaria	malaria	NOUN
cord-018764-02l423mk	366	78	tissue	tissue	NOUN
cord-018764-02l423mk	366	79	distribution	distribution	NOUN
cord-018764-02l423mk	366	80	of	of	ADP
cord-018764-02l423mk	366	81	migration	migration	NOUN
cord-018764-02l423mk	366	82	inhibitory	inhibitory	ADJ
cord-018764-02l423mk	366	83	factor	factor	NOUN
cord-018764-02l423mk	366	84	and	and	CCONJ
cord-018764-02l423mk	366	85	inducible	inducible	VERB
cord-018764-02l423mk	366	86	nitric	nitric	NOUN
cord-018764-02l423mk	366	87	oxide	oxide	NOUN
cord-018764-02l423mk	366	88	synthase	synthase	NOUN
cord-018764-02l423mk	366	89	in	in	ADP
cord-018764-02l423mk	366	90	falciparum	falciparum	NOUN
cord-018764-02l423mk	366	91	malaria	malaria	NOUN
cord-018764-02l423mk	366	92	and	and	CCONJ
cord-018764-02l423mk	366	93	sepsis	sepsis	NOUN
cord-018764-02l423mk	366	94	in	in	ADP
cord-018764-02l423mk	366	95	african	african	ADJ
cord-018764-02l423mk	366	96	children	child	NOUN
cord-018764-02l423mk	366	97	induction	induction	NOUN
cord-018764-02l423mk	366	98	of	of	ADP
cord-018764-02l423mk	366	99	ho-1	ho-1	ADJ
cord-018764-02l423mk	366	100	in	in	ADP
cord-018764-02l423mk	366	101	tissue	tissue	NOUN
cord-018764-02l423mk	366	102	macrophages	macrophage	NOUN
cord-018764-02l423mk	366	103	and	and	CCONJ
cord-018764-02l423mk	366	104	monocytes	monocyte	NOUN
cord-018764-02l423mk	366	105	in	in	ADP
cord-018764-02l423mk	366	106	fatal	fatal	ADJ
cord-018764-02l423mk	366	107	falciparum	falciparum	NOUN
cord-018764-02l423mk	366	108	malaria	malaria	NOUN
cord-018764-02l423mk	366	109	and	and	CCONJ
cord-018764-02l423mk	366	110	sepsis	sepsis	NOUN
cord-018764-02l423mk	366	111	tumor	tumor	NOUN
cord-018764-02l423mk	366	112	necrosis	necrosis	NOUN
cord-018764-02l423mk	366	113	factor	factor	NOUN
cord-018764-02l423mk	366	114	production	production	NOUN
cord-018764-02l423mk	366	115	in	in	ADP
cord-018764-02l423mk	366	116	falciparum	falciparum	NOUN
cord-018764-02l423mk	366	117	malaria	malaria	NOUN
cord-018764-02l423mk	366	118	and	and	CCONJ
cord-018764-02l423mk	366	119	its	its	PRON
cord-018764-02l423mk	366	120	association	association	NOUN
cord-018764-02l423mk	366	121	with	with	ADP
cord-018764-02l423mk	366	122	schizont	schizont	PROPN
cord-018764-02l423mk	366	123	rupture	rupture	NOUN
cord-018764-02l423mk	366	124	distinct	distinct	ADJ
cord-018764-02l423mk	366	125	patterns	pattern	NOUN
cord-018764-02l423mk	366	126	of	of	ADP
cord-018764-02l423mk	366	127	cytokine	cytokine	NOUN
cord-018764-02l423mk	366	128	regulation	regulation	NOUN
cord-018764-02l423mk	366	129	in	in	ADP
cord-018764-02l423mk	366	130	discrete	discrete	ADJ
cord-018764-02l423mk	366	131	clinical	clinical	ADJ
cord-018764-02l423mk	366	132	forms	form	NOUN
cord-018764-02l423mk	366	133	of	of	ADP
cord-018764-02l423mk	366	134	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	366	135	falciparum	falciparum	NOUN
cord-018764-02l423mk	366	136	malaria	malaria	NOUN
cord-018764-02l423mk	366	137	tumor	tumor	NOUN
cord-018764-02l423mk	366	138	necrosis	necrosis	NOUN
cord-018764-02l423mk	366	139	factor	factor	NOUN
cord-018764-02l423mk	366	140	alpha	alpha	NOUN
cord-018764-02l423mk	366	141	in	in	ADP
cord-018764-02l423mk	366	142	the	the	DET
cord-018764-02l423mk	366	143	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	366	144	of	of	ADP
cord-018764-02l423mk	366	145	cerebral	cerebral	ADJ
cord-018764-02l423mk	366	146	malaria	malaria	NOUN
cord-018764-02l423mk	366	147	variation	variation	NOUN
cord-018764-02l423mk	366	148	in	in	ADP
cord-018764-02l423mk	366	149	the	the	DET
cord-018764-02l423mk	366	150	tnf	tnf	PROPN
cord-018764-02l423mk	366	151	-	-	PUNCT
cord-018764-02l423mk	366	152	alpha	alpha	NOUN
cord-018764-02l423mk	366	153	promoter	promoter	NOUN
cord-018764-02l423mk	366	154	region	region	NOUN
cord-018764-02l423mk	366	155	associated	associate	VERB
cord-018764-02l423mk	366	156	with	with	ADP
cord-018764-02l423mk	366	157	susceptibility	susceptibility	NOUN
cord-018764-02l423mk	366	158	to	to	ADP
cord-018764-02l423mk	366	159	cerebral	cerebral	ADJ
cord-018764-02l423mk	366	160	malaria	malaria	NOUN
cord-018764-02l423mk	366	161	possible	possible	ADJ
cord-018764-02l423mk	366	162	central	central	ADJ
cord-018764-02l423mk	366	163	role	role	NOUN
cord-018764-02l423mk	366	164	of	of	ADP
cord-018764-02l423mk	366	165	nitric	nitric	NOUN
cord-018764-02l423mk	366	166	oxide	oxide	NOUN
cord-018764-02l423mk	366	167	in	in	ADP
cord-018764-02l423mk	366	168	conditions	condition	NOUN
cord-018764-02l423mk	366	169	clinically	clinically	ADV
cord-018764-02l423mk	366	170	similar	similar	ADJ
cord-018764-02l423mk	366	171	to	to	ADP
cord-018764-02l423mk	366	172	cerebral	cerebral	ADJ
cord-018764-02l423mk	366	173	malaria	malaria	NOUN
cord-018764-02l423mk	366	174	nitric	nitric	NOUN
cord-018764-02l423mk	366	175	oxide	oxide	NOUN
cord-018764-02l423mk	366	176	potently	potently	ADV
cord-018764-02l423mk	366	177	and	and	CCONJ
cord-018764-02l423mk	366	178	reversibly	reversibly	ADV
cord-018764-02l423mk	366	179	deenergizes	deenergize	VERB
cord-018764-02l423mk	366	180	mitochondria	mitochondria	NOUN
cord-018764-02l423mk	366	181	at	at	ADP
cord-018764-02l423mk	366	182	low	low	ADJ
cord-018764-02l423mk	366	183	oxygen	oxygen	NOUN
cord-018764-02l423mk	366	184	tension	tension	NOUN
cord-018764-02l423mk	366	185	tumor	tumor	NOUN
cord-018764-02l423mk	366	186	necrosis	necrosis	NOUN
cord-018764-02l423mk	366	187	factor	factor	NOUN
cord-018764-02l423mk	366	188	-	-	PUNCT
cord-018764-02l423mk	366	189	alpha	alpha	NOUN
cord-018764-02l423mk	366	190	and	and	CCONJ
cord-018764-02l423mk	366	191	lipopolysaccharide	lipopolysaccharide	NOUN
cord-018764-02l423mk	366	192	enhance	enhance	VERB
cord-018764-02l423mk	366	193	interferoninduced	interferoninduced	ADJ
cord-018764-02l423mk	366	194	antichlamydial	antichlamydial	ADJ
cord-018764-02l423mk	366	195	indoleamine	indoleamine	ADJ
cord-018764-02l423mk	366	196	dioxygenase	dioxygenase	NOUN
cord-018764-02l423mk	366	197	activity	activity	NOUN
cord-018764-02l423mk	366	198	independently	independently	ADV
cord-018764-02l423mk	366	199	lipopolysaccharide	lipopolysaccharide	VERB
cord-018764-02l423mk	366	200	induction	induction	NOUN
cord-018764-02l423mk	366	201	of	of	ADP
cord-018764-02l423mk	366	202	indoleamine	indoleamine	ADJ
cord-018764-02l423mk	366	203	2,3	2,3	NUM
cord-018764-02l423mk	366	204	-	-	PUNCT
cord-018764-02l423mk	366	205	dioxygenase	dioxygenase	NOUN
cord-018764-02l423mk	366	206	is	be	AUX
cord-018764-02l423mk	366	207	mediated	mediate	VERB
cord-018764-02l423mk	366	208	dominantly	dominantly	ADV
cord-018764-02l423mk	366	209	by	by	ADP
cord-018764-02l423mk	366	210	an	an	DET
cord-018764-02l423mk	366	211	ifn	ifn	ADJ
cord-018764-02l423mk	366	212	-	-	PUNCT
cord-018764-02l423mk	366	213	gamma	gamma	NOUN
cord-018764-02l423mk	366	214	-	-	PUNCT
cord-018764-02l423mk	366	215	independent	independent	ADJ
cord-018764-02l423mk	366	216	mechanism	mechanism	NOUN
cord-018764-02l423mk	366	217	metabolites	metabolite	NOUN
cord-018764-02l423mk	366	218	of	of	ADP
cord-018764-02l423mk	366	219	the	the	DET
cord-018764-02l423mk	366	220	kynurenine	kynurenine	NOUN
cord-018764-02l423mk	366	221	pathway	pathway	NOUN
cord-018764-02l423mk	366	222	of	of	ADP
cord-018764-02l423mk	366	223	tryptophan	tryptophan	NOUN
cord-018764-02l423mk	366	224	metabolism	metabolism	NOUN
cord-018764-02l423mk	366	225	in	in	ADP
cord-018764-02l423mk	366	226	the	the	DET
cord-018764-02l423mk	366	227	cerebrospinal	cerebrospinal	ADJ
cord-018764-02l423mk	366	228	fluid	fluid	NOUN
cord-018764-02l423mk	366	229	of	of	ADP
cord-018764-02l423mk	366	230	malawian	malawian	ADJ
cord-018764-02l423mk	366	231	children	child	NOUN
cord-018764-02l423mk	366	232	with	with	ADP
cord-018764-02l423mk	366	233	malaria	malaria	NOUN
cord-018764-02l423mk	366	234	cerebrospinal	cerebrospinal	ADJ
cord-018764-02l423mk	366	235	fluid	fluid	NOUN
cord-018764-02l423mk	366	236	studies	study	NOUN
cord-018764-02l423mk	366	237	in	in	ADP
cord-018764-02l423mk	366	238	children	child	NOUN
cord-018764-02l423mk	366	239	with	with	ADP
cord-018764-02l423mk	366	240	cerebral	cerebral	ADJ
cord-018764-02l423mk	366	241	malaria	malaria	NOUN
cord-018764-02l423mk	366	242	:	:	PUNCT
cord-018764-02l423mk	366	243	an	an	DET
cord-018764-02l423mk	366	244	excitotoxic	excitotoxic	ADJ
cord-018764-02l423mk	366	245	mechanism	mechanism	NOUN
cord-018764-02l423mk	366	246	?	?	PUNCT
cord-018764-02l423mk	367	1	does	do	VERB
cord-018764-02l423mk	367	2	malarial	malarial	ADJ
cord-018764-02l423mk	367	3	tolerance	tolerance	NOUN
cord-018764-02l423mk	367	4	,	,	PUNCT
cord-018764-02l423mk	367	5	through	through	ADP
cord-018764-02l423mk	367	6	nitric	nitric	NOUN
cord-018764-02l423mk	367	7	oxide	oxide	NOUN
cord-018764-02l423mk	367	8	,	,	PUNCT
cord-018764-02l423mk	367	9	explain	explain	VERB
cord-018764-02l423mk	367	10	the	the	DET
cord-018764-02l423mk	367	11	low	low	ADJ
cord-018764-02l423mk	367	12	incidence	incidence	NOUN
cord-018764-02l423mk	367	13	of	of	ADP
cord-018764-02l423mk	367	14	autoimmune	autoimmune	ADJ
cord-018764-02l423mk	367	15	disease	disease	NOUN
cord-018764-02l423mk	367	16	in	in	ADP
cord-018764-02l423mk	367	17	tropical	tropical	PROPN
cord-018764-02l423mk	367	18	africa	africa	PROPN
cord-018764-02l423mk	367	19	the	the	DET
cord-018764-02l423mk	367	20	role	role	NOUN
cord-018764-02l423mk	367	21	of	of	ADP
cord-018764-02l423mk	367	22	cytokines	cytokine	NOUN
cord-018764-02l423mk	367	23	in	in	ADP
cord-018764-02l423mk	367	24	plasmodium	plasmodium	PROPN
cord-018764-02l423mk	367	25	vivax	vivax	PROPN
cord-018764-02l423mk	367	26	malaria	malaria	NOUN
cord-018764-02l423mk	367	27	the	the	DET
cord-018764-02l423mk	367	28	encephalopathy	encephalopathy	ADJ
cord-018764-02l423mk	367	29	associated	associate	VERB
cord-018764-02l423mk	367	30	with	with	ADP
cord-018764-02l423mk	367	31	septic	septic	ADJ
cord-018764-02l423mk	367	32	illness	illness	NOUN
cord-018764-02l423mk	367	33	tumor	tumor	NOUN
cord-018764-02l423mk	367	34	necrosis	necrosis	NOUN
cord-018764-02l423mk	367	35	factor	factor	NOUN
cord-018764-02l423mk	367	36	alpha	alpha	NOUN
cord-018764-02l423mk	367	37	antibody	antibody	NOUN
cord-018764-02l423mk	367	38	prevents	prevent	VERB
cord-018764-02l423mk	367	39	brain	brain	NOUN
cord-018764-02l423mk	367	40	damage	damage	NOUN
cord-018764-02l423mk	367	41	of	of	ADP
cord-018764-02l423mk	367	42	rats	rat	NOUN
cord-018764-02l423mk	367	43	with	with	ADP
cord-018764-02l423mk	367	44	acute	acute	ADJ
cord-018764-02l423mk	367	45	necrotizing	necrotizing	NOUN
cord-018764-02l423mk	367	46	pancreatitis	pancreatitis	PROPN
cord-018764-02l423mk	367	47	progress	progress	NOUN
cord-018764-02l423mk	367	48	in	in	ADP
cord-018764-02l423mk	367	49	clinical	clinical	ADJ
cord-018764-02l423mk	367	50	neurosciences	neuroscience	NOUN
cord-018764-02l423mk	367	51	:	:	PUNCT
cord-018764-02l423mk	367	52	sepsis	sepsis	NOUN
cord-018764-02l423mk	367	53	-	-	PUNCT
cord-018764-02l423mk	367	54	associated	associate	VERB
cord-018764-02l423mk	367	55	encephalopathy	encephalopathy	ADV
cord-018764-02l423mk	367	56	:	:	PUNCT
cord-018764-02l423mk	367	57	evolving	evolve	VERB
cord-018764-02l423mk	367	58	concepts	concept	NOUN
cord-018764-02l423mk	367	59	influenza	influenza	NOUN
cord-018764-02l423mk	367	60	-	-	PUNCT
cord-018764-02l423mk	367	61	associated	associate	VERB
cord-018764-02l423mk	367	62	encephalopathy	encephalopathy	ADJ
cord-018764-02l423mk	367	63	:	:	PUNCT
cord-018764-02l423mk	367	64	no	no	DET
cord-018764-02l423mk	367	65	evidence	evidence	NOUN
cord-018764-02l423mk	367	66	for	for	ADP
cord-018764-02l423mk	367	67	neuroinvasion	neuroinvasion	NOUN
cord-018764-02l423mk	367	68	by	by	ADP
cord-018764-02l423mk	367	69	influenza	influenza	NOUN
cord-018764-02l423mk	367	70	virus	virus	NOUN
cord-018764-02l423mk	367	71	nor	nor	CCONJ
cord-018764-02l423mk	367	72	for	for	ADP
cord-018764-02l423mk	367	73	reactivation	reactivation	NOUN
cord-018764-02l423mk	367	74	of	of	ADP
cord-018764-02l423mk	367	75	human	human	ADJ
cord-018764-02l423mk	367	76	herpesvirus	herpesvirus	NOUN
cord-018764-02l423mk	367	77	6	6	NUM
cord-018764-02l423mk	367	78	or	or	CCONJ
cord-018764-02l423mk	367	79	7	7	NUM
cord-018764-02l423mk	367	80	encephalitis	encephalitis	NOUN
cord-018764-02l423mk	367	81	and	and	CCONJ
cord-018764-02l423mk	367	82	encephalopathy	encephalopathy	ADJ
cord-018764-02l423mk	367	83	associated	associate	VERB
cord-018764-02l423mk	367	84	with	with	ADP
cord-018764-02l423mk	367	85	an	an	DET
cord-018764-02l423mk	367	86	influenza	influenza	NOUN
cord-018764-02l423mk	367	87	epidemic	epidemic	NOUN
cord-018764-02l423mk	367	88	in	in	ADP
cord-018764-02l423mk	367	89	japan	japan	PROPN
cord-018764-02l423mk	367	90	cerebrospinal	cerebrospinal	PROPN
cord-018764-02l423mk	367	91	fluid	fluid	NOUN
cord-018764-02l423mk	367	92	and	and	CCONJ
cord-018764-02l423mk	367	93	serum	serum	NOUN
cord-018764-02l423mk	367	94	levels	level	NOUN
cord-018764-02l423mk	367	95	of	of	ADP
cord-018764-02l423mk	367	96	cytokines	cytokine	NOUN
cord-018764-02l423mk	367	97	and	and	CCONJ
cord-018764-02l423mk	367	98	soluble	soluble	ADJ
cord-018764-02l423mk	367	99	tumor	tumor	NOUN
cord-018764-02l423mk	367	100	necrosis	necrosis	NOUN
cord-018764-02l423mk	367	101	factor	factor	NOUN
cord-018764-02l423mk	367	102	receptor	receptor	NOUN
cord-018764-02l423mk	367	103	in	in	ADP
cord-018764-02l423mk	367	104	influenza	influenza	NOUN
cord-018764-02l423mk	367	105	virus	virus	NOUN
cord-018764-02l423mk	367	106	-	-	PUNCT
cord-018764-02l423mk	367	107	associated	associate	VERB
cord-018764-02l423mk	367	108	encephalopathy	encephalopathy	ADJ
cord-018764-02l423mk	367	109	analysis	analysis	NOUN
cord-018764-02l423mk	367	110	of	of	ADP
cord-018764-02l423mk	367	111	cytokine	cytokine	NOUN
cord-018764-02l423mk	367	112	levels	level	NOUN
cord-018764-02l423mk	367	113	and	and	CCONJ
cord-018764-02l423mk	367	114	nf-[kappa]b	nf-[kappa]b	NOUN
cord-018764-02l423mk	367	115	activation	activation	NOUN
cord-018764-02l423mk	367	116	in	in	ADP
cord-018764-02l423mk	367	117	peripheral	peripheral	ADJ
cord-018764-02l423mk	367	118	blood	blood	NOUN
cord-018764-02l423mk	367	119	mononuclear	mononuclear	ADJ
cord-018764-02l423mk	367	120	cells	cell	NOUN
cord-018764-02l423mk	367	121	in	in	ADP
cord-018764-02l423mk	367	122	influenza	influenza	NOUN
cord-018764-02l423mk	367	123	virus	virus	NOUN
cord-018764-02l423mk	367	124	-	-	PUNCT
cord-018764-02l423mk	367	125	associated	associate	VERB
cord-018764-02l423mk	367	126	encephalopathy	encephalopathy	ADJ
cord-018764-02l423mk	367	127	cytochrome	cytochrome	NOUN
cord-018764-02l423mk	367	128	c	c	NOUN
cord-018764-02l423mk	367	129	and	and	CCONJ
cord-018764-02l423mk	367	130	tumor	tumor	NOUN
cord-018764-02l423mk	367	131	necrosis	necrosis	NOUN
cord-018764-02l423mk	367	132	factor	factor	NOUN
cord-018764-02l423mk	367	133	-	-	PUNCT
cord-018764-02l423mk	367	134	alpha	alpha	NOUN
cord-018764-02l423mk	367	135	values	value	NOUN
cord-018764-02l423mk	367	136	in	in	ADP
cord-018764-02l423mk	367	137	serum	serum	NOUN
cord-018764-02l423mk	367	138	and	and	CCONJ
cord-018764-02l423mk	367	139	cerebrospinal	cerebrospinal	ADJ
cord-018764-02l423mk	367	140	fluid	fluid	NOUN
cord-018764-02l423mk	367	141	of	of	ADP
cord-018764-02l423mk	367	142	patients	patient	NOUN
cord-018764-02l423mk	367	143	with	with	ADP
cord-018764-02l423mk	367	144	influenza	influenza	NOUN
cord-018764-02l423mk	367	145	-	-	PUNCT
cord-018764-02l423mk	367	146	associated	associate	VERB
cord-018764-02l423mk	367	147	encephalopathy	encephalopathy	ADJ
cord-018764-02l423mk	367	148	high	high	ADJ
cord-018764-02l423mk	367	149	concentration	concentration	NOUN
cord-018764-02l423mk	367	150	of	of	ADP
cord-018764-02l423mk	367	151	serum	serum	NOUN
cord-018764-02l423mk	367	152	nitrite/	nitrite/	ADV
cord-018764-02l423mk	367	153	nitrate	nitrate	NOUN
cord-018764-02l423mk	367	154	obtained	obtain	VERB
cord-018764-02l423mk	367	155	from	from	ADP
cord-018764-02l423mk	367	156	patients	patient	NOUN
cord-018764-02l423mk	367	157	with	with	ADP
cord-018764-02l423mk	367	158	influenza	influenza	NOUN
cord-018764-02l423mk	367	159	-	-	PUNCT
cord-018764-02l423mk	367	160	associated	associate	VERB
cord-018764-02l423mk	367	161	encephalopathy	encephalopathy	ADJ
cord-018764-02l423mk	367	162	apoptosis	apoptosis	NOUN
cord-018764-02l423mk	367	163	and	and	CCONJ
cord-018764-02l423mk	367	164	microglial	microglial	ADJ
cord-018764-02l423mk	367	165	activation	activation	NOUN
cord-018764-02l423mk	367	166	in	in	ADP
cord-018764-02l423mk	367	167	influenza	influenza	NOUN
cord-018764-02l423mk	367	168	encephalopathy	encephalopathy	ADJ
cord-018764-02l423mk	367	169	pathogenesis	pathogenesis	NOUN
cord-018764-02l423mk	367	170	,	,	PUNCT
cord-018764-02l423mk	367	171	clinical	clinical	ADJ
cord-018764-02l423mk	367	172	features	feature	NOUN
cord-018764-02l423mk	367	173	,	,	PUNCT
cord-018764-02l423mk	367	174	and	and	CCONJ
cord-018764-02l423mk	367	175	neurological	neurological	ADJ
cord-018764-02l423mk	367	176	outcome	outcome	NOUN
cord-018764-02l423mk	367	177	of	of	ADP
cord-018764-02l423mk	367	178	cerebral	cerebral	ADJ
cord-018764-02l423mk	367	179	malaria	malaria	NOUN
cord-018764-02l423mk	367	180	antibodies	antibody	NOUN
cord-018764-02l423mk	367	181	to	to	ADP
cord-018764-02l423mk	367	182	voltage	voltage	NOUN
cord-018764-02l423mk	367	183	-	-	PUNCT
cord-018764-02l423mk	367	184	gated	gate	VERB
cord-018764-02l423mk	367	185	calcium	calcium	NOUN
cord-018764-02l423mk	367	186	channels	channel	NOUN
cord-018764-02l423mk	367	187	in	in	ADP
cord-018764-02l423mk	367	188	children	child	NOUN
cord-018764-02l423mk	367	189	with	with	ADP
cord-018764-02l423mk	367	190	falciparum	falciparum	PROPN
cord-018764-02l423mk	367	191	malaria	malaria	NOUN
cord-018764-02l423mk	367	192	the	the	DET
cord-018764-02l423mk	367	193	rate	rate	NOUN
cord-018764-02l423mk	367	194	of	of	ADP
cord-018764-02l423mk	367	195	mutation	mutation	NOUN
cord-018764-02l423mk	367	196	of	of	ADP
cord-018764-02l423mk	367	197	human	human	ADJ
cord-018764-02l423mk	367	198	genes	gene	NOUN
cord-018764-02l423mk	367	199	common	common	ADJ
cord-018764-02l423mk	367	200	west	west	PROPN
cord-018764-02l423mk	367	201	african	african	PROPN
cord-018764-02l423mk	367	202	hla	hla	PROPN
cord-018764-02l423mk	367	203	antigens	antigen	NOUN
cord-018764-02l423mk	367	204	are	be	AUX
cord-018764-02l423mk	367	205	associated	associate	VERB
cord-018764-02l423mk	367	206	with	with	ADP
cord-018764-02l423mk	367	207	protection	protection	NOUN
cord-018764-02l423mk	367	208	from	from	ADP
cord-018764-02l423mk	367	209	severe	severe	ADJ
cord-018764-02l423mk	367	210	malaria	malaria	NOUN
cord-018764-02l423mk	367	211	hemoglobin	hemoglobin	NOUN
cord-018764-02l423mk	367	212	c	c	PROPN
cord-018764-02l423mk	367	213	associated	associate	VERB
cord-018764-02l423mk	367	214	with	with	ADP
cord-018764-02l423mk	367	215	protection	protection	NOUN
cord-018764-02l423mk	367	216	from	from	ADP
cord-018764-02l423mk	367	217	severe	severe	ADJ
cord-018764-02l423mk	367	218	malaria	malaria	NOUN
cord-018764-02l423mk	367	219	in	in	ADP
cord-018764-02l423mk	367	220	the	the	DET
cord-018764-02l423mk	367	221	dogon	dogon	NOUN
cord-018764-02l423mk	367	222	of	of	ADP
cord-018764-02l423mk	367	223	mali	mali	PROPN
cord-018764-02l423mk	367	224	,	,	PUNCT
cord-018764-02l423mk	367	225	a	a	DET
cord-018764-02l423mk	367	226	west	west	ADJ
cord-018764-02l423mk	367	227	african	african	ADJ
cord-018764-02l423mk	367	228	population	population	NOUN
cord-018764-02l423mk	367	229	with	with	ADP
cord-018764-02l423mk	367	230	a	a	DET
cord-018764-02l423mk	367	231	low	low	ADJ
cord-018764-02l423mk	367	232	prevalence	prevalence	NOUN
cord-018764-02l423mk	367	233	of	of	ADP
cord-018764-02l423mk	367	234	hemoglobin	hemoglobin	NOUN
cord-018764-02l423mk	367	235	s	s	PART
cord-018764-02l423mk	367	236	haemoglobin	haemoglobin	PROPN
cord-018764-02l423mk	367	237	c	c	PROPN
cord-018764-02l423mk	367	238	protects	protect	VERB
cord-018764-02l423mk	367	239	against	against	ADP
cord-018764-02l423mk	367	240	clinical	clinical	ADJ
cord-018764-02l423mk	367	241	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	367	242	falciparum	falciparum	NOUN
cord-018764-02l423mk	367	243	malaria	malaria	NOUN
cord-018764-02l423mk	367	244	influence	influence	NOUN
cord-018764-02l423mk	367	245	of	of	ADP
cord-018764-02l423mk	367	246	hemoglobin	hemoglobin	PROPN
cord-018764-02l423mk	367	247	e	e	PROPN
cord-018764-02l423mk	367	248	trait	trait	NOUN
cord-018764-02l423mk	367	249	on	on	ADP
cord-018764-02l423mk	367	250	the	the	DET
cord-018764-02l423mk	367	251	severity	severity	NOUN
cord-018764-02l423mk	367	252	of	of	ADP
cord-018764-02l423mk	367	253	falciparum	falciparum	NOUN
cord-018764-02l423mk	367	254	malaria	malaria	NOUN
cord-018764-02l423mk	367	255	natural	natural	ADJ
cord-018764-02l423mk	367	256	selection	selection	NOUN
cord-018764-02l423mk	367	257	of	of	ADP
cord-018764-02l423mk	367	258	hemi	hemi	NOUN
cord-018764-02l423mk	367	259	-	-	PUNCT
cord-018764-02l423mk	367	260	and	and	CCONJ
cord-018764-02l423mk	367	261	heterozygotes	heterozygote	NOUN
cord-018764-02l423mk	367	262	for	for	ADP
cord-018764-02l423mk	367	263	g6pd	g6pd	PUNCT
cord-018764-02l423mk	367	264	deficiency	deficiency	NOUN
cord-018764-02l423mk	367	265	in	in	ADP
cord-018764-02l423mk	367	266	africa	africa	PROPN
cord-018764-02l423mk	367	267	by	by	ADP
cord-018764-02l423mk	367	268	resistance	resistance	NOUN
cord-018764-02l423mk	367	269	to	to	ADP
cord-018764-02l423mk	367	270	severe	severe	ADJ
cord-018764-02l423mk	367	271	malaria	malaria	NOUN
cord-018764-02l423mk	367	272	cellular	cellular	ADJ
cord-018764-02l423mk	367	273	mechanism	mechanism	NOUN
cord-018764-02l423mk	367	274	for	for	ADP
cord-018764-02l423mk	367	275	the	the	DET
cord-018764-02l423mk	367	276	protective	protective	ADJ
cord-018764-02l423mk	367	277	effect	effect	NOUN
cord-018764-02l423mk	367	278	of	of	ADP
cord-018764-02l423mk	367	279	haemoglobin	haemoglobin	NOUN
cord-018764-02l423mk	367	280	s	s	VERB
cord-018764-02l423mk	367	281	against	against	ADP
cord-018764-02l423mk	367	282	p.	p.	PROPN
cord-018764-02l423mk	367	283	falciparum	falciparum	NOUN
cord-018764-02l423mk	367	284	malaria	malaria	NOUN
cord-018764-02l423mk	367	285	early	early	ADJ
cord-018764-02l423mk	367	286	phagocytosis	phagocytosis	NOUN
cord-018764-02l423mk	367	287	of	of	ADP
cord-018764-02l423mk	367	288	glucose-6	glucose-6	NOUN
cord-018764-02l423mk	367	289	-	-	PUNCT
cord-018764-02l423mk	367	290	phosphate	phosphate	NOUN
cord-018764-02l423mk	367	291	dehydrogenase	dehydrogenase	NOUN
cord-018764-02l423mk	367	292	(	(	PUNCT
cord-018764-02l423mk	367	293	g6pd)-deficient	g6pd)-deficient	ADJ
cord-018764-02l423mk	367	294	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	367	295	parasitized	parasitize	VERB
cord-018764-02l423mk	367	296	by	by	ADP
cord-018764-02l423mk	367	297	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	367	298	falciparum	falciparum	NOUN
cord-018764-02l423mk	367	299	may	may	AUX
cord-018764-02l423mk	367	300	explain	explain	VERB
cord-018764-02l423mk	367	301	malaria	malaria	NOUN
cord-018764-02l423mk	367	302	protection	protection	NOUN
cord-018764-02l423mk	367	303	in	in	ADP
cord-018764-02l423mk	367	304	g6pd	g6pd	PUNCT
cord-018764-02l423mk	367	305	deficiency	deficiency	NOUN
cord-018764-02l423mk	367	306	lymphoproliferative	lymphoproliferative	ADJ
cord-018764-02l423mk	367	307	responses	response	NOUN
cord-018764-02l423mk	367	308	to	to	ADP
cord-018764-02l423mk	367	309	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	367	310	falciparum	falciparum	NOUN
cord-018764-02l423mk	367	311	antigens	antigen	NOUN
cord-018764-02l423mk	367	312	in	in	ADP
cord-018764-02l423mk	367	313	children	child	NOUN
cord-018764-02l423mk	367	314	with	with	ADP
cord-018764-02l423mk	367	315	and	and	CCONJ
cord-018764-02l423mk	367	316	without	without	ADP
cord-018764-02l423mk	367	317	the	the	DET
cord-018764-02l423mk	367	318	sickle	sickle	ADJ
cord-018764-02l423mk	367	319	cell	cell	NOUN
cord-018764-02l423mk	367	320	trait	trait	NOUN
cord-018764-02l423mk	367	321	abnormal	abnormal	ADJ
cord-018764-02l423mk	367	322	display	display	NOUN
cord-018764-02l423mk	367	323	of	of	ADP
cord-018764-02l423mk	367	324	pfemp-1	pfemp-1	NOUN
cord-018764-02l423mk	367	325	on	on	ADP
cord-018764-02l423mk	367	326	erythrocytes	erythrocyte	NOUN
cord-018764-02l423mk	367	327	carrying	carry	VERB
cord-018764-02l423mk	367	328	haemoglobin	haemoglobin	NOUN
cord-018764-02l423mk	367	329	c	c	PROPN
cord-018764-02l423mk	367	330	may	may	AUX
cord-018764-02l423mk	367	331	protect	protect	VERB
cord-018764-02l423mk	367	332	against	against	ADP
cord-018764-02l423mk	367	333	malaria	malaria	NOUN
cord-018764-02l423mk	367	334	a	a	DET
cord-018764-02l423mk	367	335	new	new	ADJ
cord-018764-02l423mk	367	336	look	look	NOUN
cord-018764-02l423mk	367	337	at	at	ADP
cord-018764-02l423mk	367	338	the	the	DET
cord-018764-02l423mk	367	339	protection	protection	NOUN
cord-018764-02l423mk	367	340	of	of	ADP
cord-018764-02l423mk	367	341	hemoglobin	hemoglobin	NOUN
cord-018764-02l423mk	367	342	as	as	ADP
cord-018764-02l423mk	367	343	and	and	CCONJ
cord-018764-02l423mk	367	344	ac	ac	PROPN
cord-018764-02l423mk	367	345	genotypes	genotype	NOUN
cord-018764-02l423mk	367	346	against	against	ADP
cord-018764-02l423mk	367	347	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	367	348	falciparum	falciparum	NOUN
cord-018764-02l423mk	367	349	infection	infection	NOUN
cord-018764-02l423mk	367	350	:	:	PUNCT
cord-018764-02l423mk	367	351	a	a	DET
cord-018764-02l423mk	367	352	census	census	NOUN
cord-018764-02l423mk	367	353	tract	tract	NOUN
cord-018764-02l423mk	367	354	approach	approach	NOUN
cord-018764-02l423mk	367	355	hemoglobin	hemoglobin	NOUN
cord-018764-02l423mk	367	356	c	c	PROPN
cord-018764-02l423mk	367	357	and	and	CCONJ
cord-018764-02l423mk	367	358	resistance	resistance	NOUN
cord-018764-02l423mk	367	359	to	to	ADP
cord-018764-02l423mk	367	360	severe	severe	ADJ
cord-018764-02l423mk	367	361	malaria	malaria	NOUN
cord-018764-02l423mk	367	362	in	in	ADP
cord-018764-02l423mk	367	363	ghanaian	ghanaian	ADJ
cord-018764-02l423mk	367	364	children	child	NOUN
cord-018764-02l423mk	367	365	red	red	ADJ
cord-018764-02l423mk	367	366	blood	blood	NOUN
cord-018764-02l423mk	367	367	cells	cell	NOUN
cord-018764-02l423mk	367	368	that	that	PRON
cord-018764-02l423mk	367	369	do	do	VERB
cord-018764-02l423mk	367	370	and	and	CCONJ
cord-018764-02l423mk	367	371	red	red	ADJ
cord-018764-02l423mk	367	372	blood	blood	NOUN
cord-018764-02l423mk	367	373	cells	cell	NOUN
cord-018764-02l423mk	367	374	that	that	PRON
cord-018764-02l423mk	367	375	do	do	VERB
cord-018764-02l423mk	367	376	n't	not	PART
cord-018764-02l423mk	367	377	:	:	PUNCT
cord-018764-02l423mk	367	378	how	how	SCONJ
cord-018764-02l423mk	367	379	to	to	PART
cord-018764-02l423mk	367	380	resist	resist	VERB
cord-018764-02l423mk	367	381	a	a	DET
cord-018764-02l423mk	367	382	persistent	persistent	ADJ
cord-018764-02l423mk	367	383	parasite	parasite	NOUN
cord-018764-02l423mk	367	384	the	the	DET
cord-018764-02l423mk	367	385	effect	effect	NOUN
cord-018764-02l423mk	367	386	of	of	ADP
cord-018764-02l423mk	367	387	alpha+-thalassaemia	alpha+-thalassaemia	ADV
cord-018764-02l423mk	367	388	on	on	ADP
cord-018764-02l423mk	367	389	the	the	DET
cord-018764-02l423mk	367	390	incidence	incidence	NOUN
cord-018764-02l423mk	367	391	of	of	ADP
cord-018764-02l423mk	367	392	malaria	malaria	NOUN
cord-018764-02l423mk	367	393	and	and	CCONJ
cord-018764-02l423mk	367	394	other	other	ADJ
cord-018764-02l423mk	367	395	diseases	disease	NOUN
cord-018764-02l423mk	367	396	in	in	ADP
cord-018764-02l423mk	367	397	children	child	NOUN
cord-018764-02l423mk	367	398	living	live	VERB
cord-018764-02l423mk	367	399	on	on	ADP
cord-018764-02l423mk	367	400	the	the	DET
cord-018764-02l423mk	367	401	coast	coast	NOUN
cord-018764-02l423mk	367	402	of	of	ADP
cord-018764-02l423mk	367	403	kenya	kenya	PROPN
cord-018764-02l423mk	367	404	high	high	ADJ
cord-018764-02l423mk	367	405	incidence	incidence	NOUN
cord-018764-02l423mk	367	406	of	of	ADP
cord-018764-02l423mk	367	407	malaria	malaria	NOUN
cord-018764-02l423mk	367	408	in	in	ADP
cord-018764-02l423mk	367	409	alpha	alpha	ADJ
cord-018764-02l423mk	367	410	-	-	PUNCT
cord-018764-02l423mk	367	411	thalassaemic	thalassaemic	ADJ
cord-018764-02l423mk	367	412	children	child	NOUN
cord-018764-02l423mk	367	413	high	high	ADJ
cord-018764-02l423mk	367	414	prevalence	prevalence	NOUN
cord-018764-02l423mk	367	415	of	of	ADP
cord-018764-02l423mk	367	416	human	human	ADJ
cord-018764-02l423mk	367	417	antibodies	antibody	NOUN
cord-018764-02l423mk	367	418	to	to	PART
cord-018764-02l423mk	367	419	recombinant	recombinant	VERB
cord-018764-02l423mk	367	420	duffy	duffy	ADJ
cord-018764-02l423mk	367	421	binding	bind	VERB
cord-018764-02l423mk	367	422	-	-	PUNCT
cord-018764-02l423mk	367	423	like	like	ADJ
cord-018764-02l423mk	367	424	alpha	alpha	NOUN
cord-018764-02l423mk	367	425	domains	domain	NOUN
cord-018764-02l423mk	367	426	of	of	ADP
cord-018764-02l423mk	367	427	the	the	DET
cord-018764-02l423mk	367	428	plasmodium	plasmodium	NOUN
cord-018764-02l423mk	367	429	falciparum	falciparum	NOUN
cord-018764-02l423mk	367	430	-	-	PUNCT
cord-018764-02l423mk	367	431	infected	infect	VERB
cord-018764-02l423mk	367	432	erythrocyte	erythrocyte	NOUN
cord-018764-02l423mk	367	433	membrane	membrane	NOUN
cord-018764-02l423mk	367	434	protein	protein	NOUN
cord-018764-02l423mk	367	435	1	1	NUM
cord-018764-02l423mk	367	436	in	in	ADP
cord-018764-02l423mk	367	437	semi	semi	ADJ
cord-018764-02l423mk	367	438	-	-	ADJ
cord-018764-02l423mk	367	439	immune	immune	ADJ
cord-018764-02l423mk	367	440	adults	adult	NOUN
cord-018764-02l423mk	367	441	compared	compare	VERB
cord-018764-02l423mk	367	442	to	to	ADP
cord-018764-02l423mk	367	443	that	that	PRON
cord-018764-02l423mk	367	444	in	in	ADP
cord-018764-02l423mk	367	445	non	non	ADJ
cord-018764-02l423mk	367	446	-	-	ADJ
cord-018764-02l423mk	367	447	immune	immune	ADJ
cord-018764-02l423mk	367	448	children	child	NOUN
cord-018764-02l423mk	367	449	seasonal	seasonal	ADJ
cord-018764-02l423mk	367	450	childhood	childhood	NOUN
cord-018764-02l423mk	367	451	anaemia	anaemia	NOUN
cord-018764-02l423mk	367	452	in	in	ADP
cord-018764-02l423mk	367	453	west	west	PROPN
cord-018764-02l423mk	367	454	africa	africa	PROPN
cord-018764-02l423mk	367	455	is	be	AUX
cord-018764-02l423mk	367	456	associated	associate	VERB
cord-018764-02l423mk	367	457	with	with	ADP
cord-018764-02l423mk	367	458	the	the	DET
cord-018764-02l423mk	367	459	haptoglobin	haptoglobin	NOUN
cord-018764-02l423mk	367	460	2	2	NUM
cord-018764-02l423mk	367	461	-	-	SYM
cord-018764-02l423mk	367	462	2	2	NUM
cord-018764-02l423mk	367	463	genotype	genotype	NOUN
cord-018764-02l423mk	367	464	negative	negative	ADJ
cord-018764-02l423mk	367	465	epistasis	epistasis	NOUN
cord-018764-02l423mk	367	466	between	between	ADP
cord-018764-02l423mk	367	467	the	the	DET
cord-018764-02l423mk	367	468	malaria	malaria	NOUN
cord-018764-02l423mk	367	469	-	-	PUNCT
cord-018764-02l423mk	367	470	protective	protective	ADJ
cord-018764-02l423mk	367	471	effects	effect	NOUN
cord-018764-02l423mk	367	472	of	of	ADP
cord-018764-02l423mk	367	473	alpha(+)-thalassemia	alpha(+)-thalassemia	NOUN
cord-018764-02l423mk	367	474	and	and	CCONJ
cord-018764-02l423mk	367	475	the	the	DET
cord-018764-02l423mk	367	476	sickle	sickle	ADJ
cord-018764-02l423mk	367	477	cell	cell	NOUN
cord-018764-02l423mk	367	478	trait	trait	NOUN
cord-018764-02l423mk	367	479	reversing	reverse	VERB
cord-018764-02l423mk	367	480	established	establish	VERB
cord-018764-02l423mk	367	481	sepsis	sepsis	NOUN
cord-018764-02l423mk	367	482	with	with	ADP
cord-018764-02l423mk	367	483	antagonists	antagonist	NOUN
cord-018764-02l423mk	367	484	of	of	ADP
cord-018764-02l423mk	367	485	endogenous	endogenous	ADJ
cord-018764-02l423mk	367	486	high	high	ADJ
cord-018764-02l423mk	367	487	-	-	PUNCT
cord-018764-02l423mk	367	488	mobility	mobility	NOUN
cord-018764-02l423mk	367	489	group	group	NOUN
cord-018764-02l423mk	367	490	box	box	PROPN
cord-018764-02l423mk	367	491	1	1	NUM
cord-018764-02l423mk	367	492	ethyl	ethyl	PROPN
cord-018764-02l423mk	367	493	pyruvate	pyruvate	PROPN
cord-018764-02l423mk	367	494	prevents	prevent	VERB
cord-018764-02l423mk	367	495	lethality	lethality	NOUN
cord-018764-02l423mk	367	496	in	in	ADP
cord-018764-02l423mk	367	497	mice	mouse	NOUN
cord-018764-02l423mk	367	498	with	with	ADP
cord-018764-02l423mk	367	499	established	establish	VERB
cord-018764-02l423mk	367	500	lethal	lethal	ADJ
cord-018764-02l423mk	367	501	sepsis	sepsis	NOUN
cord-018764-02l423mk	367	502	and	and	CCONJ
cord-018764-02l423mk	367	503	systemic	systemic	ADJ
cord-018764-02l423mk	367	504	inflammation	inflammation	NOUN
cord-018764-02l423mk	367	505	randomized	randomize	VERB
cord-018764-02l423mk	367	506	trial	trial	NOUN
cord-018764-02l423mk	367	507	of	of	ADP
cord-018764-02l423mk	367	508	volume	volume	NOUN
cord-018764-02l423mk	367	509	expansion	expansion	NOUN
cord-018764-02l423mk	367	510	with	with	ADP
cord-018764-02l423mk	367	511	albumin	albumin	NOUN
cord-018764-02l423mk	367	512	or	or	CCONJ
cord-018764-02l423mk	367	513	saline	saline	NOUN
cord-018764-02l423mk	367	514	in	in	ADP
cord-018764-02l423mk	367	515	children	child	NOUN
cord-018764-02l423mk	367	516	with	with	ADP
cord-018764-02l423mk	367	517	severe	severe	ADJ
cord-018764-02l423mk	367	518	malaria	malaria	NOUN
cord-018764-02l423mk	367	519	:	:	PUNCT
cord-018764-02l423mk	367	520	preliminary	preliminary	ADJ
cord-018764-02l423mk	367	521	evidence	evidence	NOUN
cord-018764-02l423mk	367	522	of	of	ADP
cord-018764-02l423mk	367	523	albumin	albumin	NOUN
cord-018764-02l423mk	367	524	benefit	benefit	NOUN
cord-018764-02l423mk	367	525	pharmacokinetics	pharmacokinetic	NOUN
cord-018764-02l423mk	367	526	and	and	CCONJ
cord-018764-02l423mk	367	527	pharmacodynamics	pharmacodynamic	NOUN
cord-018764-02l423mk	367	528	of	of	ADP
cord-018764-02l423mk	367	529	dichloroacetate	dichloroacetate	NOUN
cord-018764-02l423mk	367	530	in	in	ADP
cord-018764-02l423mk	367	531	children	child	NOUN
cord-018764-02l423mk	367	532	with	with	ADP
cord-018764-02l423mk	367	533	lactic	lactic	ADJ
cord-018764-02l423mk	367	534	acidosis	acidosis	NOUN
cord-018764-02l423mk	367	535	due	due	ADP
cord-018764-02l423mk	367	536	to	to	ADP
cord-018764-02l423mk	367	537	severe	severe	ADJ
cord-018764-02l423mk	367	538	malaria	malaria	NOUN
cord-018764-02l423mk	367	539	oxidative	oxidative	ADJ
cord-018764-02l423mk	367	540	stress	stress	NOUN
cord-018764-02l423mk	367	541	and	and	CCONJ
cord-018764-02l423mk	367	542	rheology	rheology	NOUN
cord-018764-02l423mk	367	543	in	in	ADP
cord-018764-02l423mk	367	544	severe	severe	ADJ
cord-018764-02l423mk	367	545	malaria	malaria	NOUN
cord-018764-02l423mk	367	546	a	a	DET
cord-018764-02l423mk	367	547	pilot	pilot	NOUN
cord-018764-02l423mk	367	548	study	study	NOUN
cord-018764-02l423mk	367	549	of	of	ADP
cord-018764-02l423mk	367	550	n	n	NOUN
cord-018764-02l423mk	367	551	-	-	NOUN
cord-018764-02l423mk	367	552	acetylcysteine	acetylcysteine	NOUN
cord-018764-02l423mk	367	553	as	as	ADP
cord-018764-02l423mk	367	554	adjunctive	adjunctive	ADJ
cord-018764-02l423mk	367	555	therapy	therapy	NOUN
cord-018764-02l423mk	367	556	for	for	ADP
cord-018764-02l423mk	367	557	severe	severe	ADJ
cord-018764-02l423mk	367	558	malaria	malaria	NOUN
cord-018764-02l423mk	367	559	inhibition	inhibition	NOUN
cord-018764-02l423mk	367	560	of	of	ADP
cord-018764-02l423mk	367	561	endothelial	endothelial	ADJ
cord-018764-02l423mk	367	562	activation	activation	NOUN
cord-018764-02l423mk	367	563	:	:	PUNCT
cord-018764-02l423mk	367	564	a	a	DET
cord-018764-02l423mk	367	565	new	new	ADJ
cord-018764-02l423mk	367	566	way	way	NOUN
cord-018764-02l423mk	367	567	to	to	PART
cord-018764-02l423mk	367	568	treat	treat	VERB
cord-018764-02l423mk	367	569	cerebral	cerebral	ADJ
cord-018764-02l423mk	367	570	malaria	malaria	NOUN
