# bib

id: cord-356223-8qn164k5
author: Yu, Hannah J.
date: 2020-08-15
extension: .txt
mime: text/plain
words: 1815
sentence: 60
flesch: 35
cache: cache/cord-356223-8qn164k5.txt
txt: txt/cord-356223-8qn164k5.txt
title:
  Home Monitoring of Age-Related Macular Degeneration: Real-World Utility of the ForeseeHome Device for Detection of Neovascularization

summary:
  I. Outline and 446 major prevalence findings Cataracts and macular degeneration in older Americans Causes and prevalence of visual impairment 452 among adults in the United States global update of available data on visual 455 impairment: a compilation of population-based prevalence studies Prevalence of age-related macular 458 degeneration in the United States Age-Related Macular Degeneration (AMD) Tables. A case-control study in the age-related eye disease study Associations of cardiovascular disease and its risk 489 factors with age-related macular degeneration: the POLA study Age-related macular degeneration and incident 492 cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis Hypertension, cardiovascular disease, and age-495 related macular degeneration.


id: cord-323227-ctsamv69
author: Bonner, C.
date: 2020-05-08
extension: .txt
mime: text/plain
words: 2604
sentence: 107
flesch: 41
cache: cache/cord-323227-ctsamv69.txt
txt: txt/cord-323227-ctsamv69.txt
title:
  Protocol for a systematic review of qualitative and quantitative effects of cardiovascular disease risk communication using heart age concepts

summary:
  key: cord-323227-ctsamv69 authors: Bonner, C.; Cornell, S.; Batcup, C.; Fajardo, M.; Doust, J.; McGeechan, K.; Trevena, L. title: Protocol for a systematic review of qualitative and quantitative effects of cardiovascular disease risk communication using heart age concepts date: 2020-05-08 journal: nan DOI: 10.1101/2020.05.03.20089938 sha: doc_id: 323227 cord_uid: ctsamv69 Introduction: The concept of heart age is increasingly used for health promotion and alongside clinical guidelines for cardiovascular disease (CVD) prevention. Methods and analysis: We aim to systematically review both qualitative and quantitative evidence of the effects of heart age when presented to patients or consumers for the purpose of CVD risk communication.


id: cord-317519-yhzv2yjs
author: Barzilai, Nir
title: Geroscience in the Age of COVID-19
date: 2020-07-23
extension: .txt
mime: text/plain
words: 2595
sentence: 88
flesch: 31
cache: cache/cord-317519-yhzv2yjs.txt
txt: txt/cord-317519-yhzv2yjs.txt
summary:
  Healthy aging: the ultimate preventative medicine Immunosenescence: emerging challenges for an ageing population Benefits of metformin in attenuating the hallmarks of aging Metformin as a tool to target aging Metformin: historical overview Metformin improves in vivo and in vitro B cell function in individuals with obesity and Type-2 Diabetes Metformin treatment was associated with decreased mortality in COVID-19 patients with diabetes in a retrospective analysis Observational study of metformin and risk of mortality in patients hospitalized with Covid-19 mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells mTOR inhibition improves immune function in the elderly TORC1 inhibition enhances immune function and reduces infections in the elderly A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: immunological, physical performance, and cognitive effects Rapamycin for longevity: opinion article Innate and adaptive immunity in aging and longevity: the foundation of resilience Quantification of biological aging in young adults Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area Renin-Angiotensin-Aldosterone system inhibitors in patients with Covid-19 Strategies and challenges in clinical trials targeting human aging Recognizing degenerative aging as a treatable medical condition: methodology and policy Measuring biological aging in humans: a quest The critical need to promote research of aging and aging-related diseases to improve health and longevity of the elderly population Aging health and R&D for healthy longevity must be included into the WHO Work Program Strategies must be developed for periodic frailty assessment with continuous longitudinal follow-up of older persons which may reveal not only global determinants that are conserved, but also local singularities involved in differential aging health around the world.


id: cord-322024-yrqpq9cf
author: Jevšnik, Monika
date: 2013-02-05
extension: .txt
mime: text/plain
words: 3928
sentence: 143
flesch: 51
cache: cache/cord-322024-yrqpq9cf.txt
txt: txt/cord-322024-yrqpq9cf.txt
title:
  Detection of human coronaviruses in simultaneously collected stool samples and nasopharyngeal swabs from hospitalized children with acute gastroenteritis

summary:
  In 174 of the patients, both stool and NP swab samples were obtained, while only stool sample was obtained from nine children and solely NP swab was available from nine others. In NP swabs respiratory syncytial virus (RSV), influenza viruses A and B (Flu A-B), parainfluenza viruses 1-3 (PIV 1-3), metapneumovirus (hMPV), human bocavirus (HBoVs), adenovirus (AdV) and rhinovirus (hRV)


id: cord-294501-1nf98mpb
author: Bonafè, Massimiliano
title: Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes
date: 2020-05-03
extension: .txt
mime: text/plain
words: 3754
sentence: 140
flesch: 33
cache: cache/cord-294501-1nf98mpb.txt
txt: txt/cord-294501-1nf98mpb.txt
summary:
  25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon Interaction of severe acute respiratory syndrome-coronavirus and NL63 coronavirus spike proteins with angiotensin converting enzyme-2 A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus, A first step in understanding SARS pathogenesis SARS coronavirus-induced lung injury Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg(9) bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice The clinical pathology of severe acute respiratory syndrome (SARS): a report from China Endothelial cell senescence in aging-related vascular dysfunction Individual variation of the SARS-CoV2 receptor ACE2 gene expression and regulation Comparative genetic analysis of the novel coronavirus (2019-nCoV/ SARS-CoV-2) receptor ACE2 in different populations Inflammaging 2018: an update and a model Senescence-associated secretory phenotypes reveal cellnonautonomous functions of oncogenic RAS and the p53 tumor suppressor Senescence associated macrophages and macroph-aging: Are they pieces of the same puzzle? Age-related M1/M2 phenotype changes in circulating monocytes from healthy/unhealthy individuals Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses Cells exhibiting strong p16 (INK4a) promoter activation in vivo display features of senescence PAI-1 regulation of TGF-beta1-induced alveolar type II cell senescence, SASP secretion, and SASP-mediated activation of alveolar macrophages The telomere world and aging: analytical challenges and future perspectives The hallmarks of aging Sex differences in telomeres and lifespan Changes in the biochemical taste of cytoplasmic and cell-free DNA are major fuels for inflamm-aging Exploiting the telomere machinery to put the brakes on inflamm-aging Shorter leukocyte telomere length is associated with higher risk of infections: a prospective study of 75,309 individuals from the general population DNA methylation age of human tissues and cell types Regeneron, Sanofi to Test Arthritis Drug as Coronavirus Treatment, Wall Street Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease Anti-senescence compounds: a potential nutraceutical approach to healthy aging Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation A suppressive oligodeoxynucleotide expressing TTAGGG motifs modulates cellular energetics through the mTOR signaling pathway Suppressive oligonucleotides inhibit inflammation in a murine model of mechanical ventilator induced lung injury Biological age predictors Where metabolism meets senescence: focus on endothelial cells Measuring biological aging in humans: a quest Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells Circulating miRNAs and miRNA shuttles as biomarkers: perspective trajectories of healthy and unhealthy aging COVID-19 illness in native and immunosuppressed states: a clinical-therapeutic staging proposal We are grateful to Word Designs for text editing (www. silviamodena.com).


id: cord-335635-41u0cq1h
author: Huynh, Hieu Trung
title: Joint Age Estimation and Gender Classification of Asian Faces Using Wide ResNet
date: 2020-08-27
extension: .txt
mime: text/plain
words: 4525
sentence: 215
flesch: 55
cache: cache/cord-335635-41u0cq1h.txt
txt: txt/cord-335635-41u0cq1h.txt
summary:
  Considering that Asian people makes up to ~ 60% of the world population, that is indeed a serious downfall for such models. The trained network is then used for age estimation and gender classification, as shown in Fig. 1b .


id: cord-323582-7y8pt72r
author: Ahamad, Martuza
title: A Machine Learning Model to Identify Early Stage Symptoms of SARS-Cov-2 Infected Patients
date: 2020-06-20
extension: .txt
mime: text/plain
words: 4458
sentence: 201
flesch: 51
cache: cache/cord-323582-7y8pt72r.txt
txt: txt/cord-323582-7y8pt72r.txt
summary:
  • Identification of the significant symptoms of COVID-19 patients by analyzing their association using five different machine learning approaches. We calculated the coefficient values for each feature that are significant for COVID-19 patients.


id: cord-312840-jvdph782
author: White, Laura F
title: Determining the dynamics of influenza transmission by age
date: 2014-03-21
extension: .txt
mime: text/plain
words: 5039
sentence: 211
flesch: 51
cache: cache/cord-312840-jvdph782.txt
txt: txt/cord-312840-jvdph782.txt
summary:
  The authors report two matrices with age specific contact patterns in five year intervals up to a 45+ category. key: cord-312840-jvdph782 authors: White, Laura F; Archer, Brett; Pagano, Marcello title: Determining the dynamics of influenza transmission by age date: 2014-03-21 journal: Emerg Themes Epidemiol DOI: 10.1186/1742-7622-11-4 sha: doc_id: 312840 cord_uid: jvdph782 BACKGROUND: It is widely accepted that influenza transmission dynamics vary by age; however methods to quantify the reproductive number by age group are limited.


id: cord-352620-a0tt0ldm
author: Lawler, Dennis
title: Pathology of Gray Wolf Shoulders: Lessons in Species and Aging
date: 2016-07-30
extension: .txt
mime: text/plain
words: 4408
sentence: 208
flesch: 37
cache: cache/cord-352620-a0tt0ldm.txt
txt: txt/cord-352620-a0tt0ldm.txt
summary:
  PATHOLOGY OF GRAY WOLF SHOULDERS excess) contributions to degenerative shoulder joint disease, with the possible exception of Ruedi. We found no literature reports of shoulder disease in gray wolves.


id: cord-322486-qwl7nzkr
author: Omori, Ryosuke
date: 2020-10-06
extension: .txt
mime: text/plain
words: 4859
sentence: 153
flesch: 39
cache: cache/cord-322486-qwl7nzkr.txt
txt: txt/cord-322486-qwl7nzkr.txt
title:
  The age distribution of mortality from novel coronavirus disease (COVID-19) suggests no large difference of susceptibility by age

summary:
  The sensitivity of transmission coefficient β against age distribution of mortality when it was assumed that age-dependent mortality was proportional to cCFR per age group. We modelled age specific susceptibility as where c is susceptibility among age group 1 and a constant among all age groups, φ denotes the exponent parameter describing the variation of susceptibility among age groups.


id: cord-344653-to7571tw
author: Whatley, Mary C.
title: Younger and Older Adults’ Mood and Expectations Regarding Aging During COVID-19
date: 2020-09-16
extension: .txt
mime: text/plain
words: 4995
sentence: 187
flesch: 51
cache: cache/cord-344653-to7571tw.txt
txt: txt/cord-344653-to7571tw.txt
summary:
  In Study 1, older adults completed a mood and expectations regarding aging survey up to 2 years prior to the pandemic and again in April, 2020 (during the pandemic). Older adults’ mood and expectations regarding aging remained fairly constant, and younger adults showed lower mood and expectations regarding aging than did older adults, despite older adults showing greater concern about COVID-19.


id: cord-318977-4ng6gxpv
author: Zittoun, Tania
date: 2020-09-26
extension: .txt
mime: text/plain
words: 5658
sentence: 164
flesch: 32
cache: cache/cord-318977-4ng6gxpv.txt
txt: txt/cord-318977-4ng6gxpv.txt
title:
  The relevance of a sociocultural perspective for understanding learning and development in older age

summary:
  First, having lived longer lives, older people are more likely to have lived through more spheres of experiences, and more reconfiguration of spheres of experiences than younger people: many family or friend-related experiences, numerous professional situations, situations related to social life, events related to leisure activities, diverse cultural events. At another extreme, older people may have developed negative representations of institutions and the social world, which, they feel, have closed down their opportunities to participate; excluded from social life, with spheres of experience that may be less satisfying, the may have very little occasions to produce meaningful activities and therefore to develop imaginations of their future.


id: cord-331065-tzvkj2rm
author: Terracciano, Antonio
title: Changes in Subjective Age During COVID-19
date: 2020-08-07
extension: .txt
mime: text/plain
words: 5695
sentence: 208
flesch: 49
cache: cache/cord-331065-tzvkj2rm.txt
txt: txt/cord-331065-tzvkj2rm.txt
summary:
  Daily health, stressors, and affect explain day-to-day variability in subjective age Countries and cultural differences in the stigma of mental illness: The east-west divide The trajectory of loneliness in response to COVID-19 Reducing ageism: Education about aging and extended contact with older adults You're only as old as you feel: Selfperceptions of age, fears of aging, and life satisfaction from adolescence to old age Video calls for reducing social isolation and loneliness in older people: a rapid review Patients Dying in Relation to COVID-19 in Italy Subjective age and perceived distance-to-death moderate the association between posttraumatic stress symptoms and posttraumatic growth among older adults Understanding the long-term connections between posttraumatic stress, subjective age, and successful aging among midlife and older adults HLM (Version 6) Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area Is the relationship between subjective age, depressive symptoms and activities of daily living bidirectional? People over forty feel 20% younger than their age: Subjective age across the lifespan Development of the 12-item expectations regarding aging survey Age identity in context: Stress and the subjective side of aging Feeling younger, being stronger: An experimental study of subjective age and physical functioning among older adults Subjective age and changes in memory in older adults How old do you feel? To examine change in subjective age with the emergence of coronavirus disease 2019 (COVID-19).


id: cord-309885-6sjxi2et
author: Maremanda, Krishna P.
date: 2020-09-09
extension: .txt
mime: text/plain
words: 6449
sentence: 231
flesch: 47
cache: cache/cord-309885-6sjxi2et.txt
txt: txt/cord-309885-6sjxi2et.txt
title:
  Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis

summary:
  Here, we analyzed differentially expressed transcript levels among old non-smokers vs. old smokers, old smokers vs. old COPD, and old non-smokers vs. old COPD groups. Overall, four genes PARP1, SIRT6, KLOTHO, and CDKN1C were among the common target genes that were differentially expressed in the young COPD group as compared to young non-smokers and young smokers groups.


id: cord-340285-mq9x12nw
author: Blagosklonny, Mikhail V.
title: From causes of aging to death from COVID-19
date: 2020-06-12
extension: .txt
mime: text/plain
words: 5970
sentence: 314
flesch: 39
cache: cache/cord-340285-mq9x12nw.txt
txt: txt/cord-340285-mq9x12nw.txt
summary:
  This review is intended for a professional audience, to stimulate new ideas and to aid the global efforts to develop effective treatments for COVID-19 disease. Geroscience: linking aging to chronic disease Rejuvenating immunity: anti-aging drug today eight years later mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells Rapamycin-induced enhancement of vaccine efficacy in mice Immunostimulatory activity of lifespan-extending agents mTOR regulates memory CD8 t-cell differentiation Paradoxical aspects of rapamycin immunobiology in transplantation Sirolimus enhances the magnitude and quality of viralspecific CD8+ t-cell responses to vaccinia virus vaccination in rhesus macaques Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice mTOR inhibition improves immune function in the elderly TORC1 inhibition enhances immune function and reduces infections in the elderly Cutting edge: rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses Aging, obesity, and inflammatory age-related diseases Immunosenescence in aging: between immune cells depletion and cytokines up-regulation mTORC1 signaling governs hematopoietic stem cell quiescence Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells Geroconversion of aged muscle stem cells under regenerative pressure Microenvironmental contributions to hematopoietic stem cell aging Long-term adaptation to hypoxia preserves hematopoietic stem cell function Regulation of the HIF-1alpha level is essential for hematopoietic stem cells Hypoxia suppresses conversion from proliferative arrest to cellular senescence Rapamycin enhances long-term hematopoietic reconstitution of ex vivo expanded mouse hematopoietic stem cells by inhibiting senescence Rapamycin is highly effective in murine models of immune-mediated bone marrow failure Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway.


id: cord-306504-0wq7rc6s
author: Barakovic Husic, Jasmina
title: Aging at Work: A Review of Recent Trends and Future Directions
date: 2020-10-20
extension: .txt
mime: text/plain
words: 6414
sentence: 367
flesch: 48
cache: cache/cord-306504-0wq7rc6s.txt
txt: txt/cord-306504-0wq7rc6s.txt
summary:
  active aging at work, older adults at work, successful aging at work, healthy aging at work, productive aging at work Motivations deficit, discrimination, growth Solutions EU policy, assistance schemes, eligibility criteria, legislation, national policy active aging at work healthy aging at work older adults at work productive aging at work successful aging at work . [25] to review the literature on aging at work policies.


id: cord-311029-x0lk4110
author: Palermo, Sara
title: Covid-19 Pandemic: Maximizing Future Vaccination Treatments Considering Aging and Frailty
date: 2020-09-18
extension: .txt
mime: text/plain
words: 6416
sentence: 250
flesch: 33
cache: cache/cord-311029-x0lk4110.txt
txt: txt/cord-311029-x0lk4110.txt
summary:
  Indeed, if any cross-reactive epitopes were identified between COVID-19 and SARS-CoV, previous vaccine for SARS-CoV might be re-utilized to facilitate COVID-19 vaccine development (65) . [(72) , p. 234], strategies to improve vaccine uptake can target all the components underpinning low coverage, and include technology and communication-based strategies, physician-centered approaches, targeting healthcare workers for influenza vaccination, systembased factors, improved vaccine efficacy, and above all, political will and leadership.


id: cord-352737-3ttrx3lf
author: Cunha, Lucas Leite
date: 2020-08-07
extension: .txt
mime: text/plain
words: 6832
sentence: 223
flesch: 27
cache: cache/cord-352737-3ttrx3lf.txt
txt: txt/cord-352737-3ttrx3lf.txt
title:
  Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response

summary:
  In fact, diet, exercise, xenobiotic exposure, and other environmental factors may epigenetically affect the metabolic health of immune cells (22) . Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age Granule exocytosis mediates immune surveillance of senescent cells Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity Age-related changes in natural killer cell receptors from childhood through old age Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence Age-related alterations in the inflammatory response to dermal injury Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion Peripheral blood dendritic cells and monocytes are differently regulated in the elderly Aging of the innate immune system Neutrophil extracellular traps kill bacteria Deficiency of adenosine deaminase 2 triggers adenosinemediated NETosis and TNF production in patients with DADA2 Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans Effect of age on human neutrophil function Neutrophil ageing and immunesenescence Cellular signaling in the aging immune system Signal transduction and functional changes in neutrophils with aging Effects of aging on triggering receptor expressed on myeloid cells (TREM)-1-induced PMN functions Leukocyte function and life span in a murine model of premature immunosenescence Relation of behaviour and macrophage function to life span in a murine model of premature immunosenescence Oxidativeinflammatory stress in immune cells from adult mice with premature aging Premature aging in behavior and immune functions in tyrosine hydroxylase haploinsufficient female mice.


id: cord-325722-ixozph19
author: Yip, Paul
title: Optimal Strategies for Reducing Number of People in the Social Security System
date: 2020-02-18
extension: .txt
mime: text/plain
words: 7499
sentence: 302
flesch: 55
cache: cache/cord-325722-ixozph19.txt
txt: txt/cord-325722-ixozph19.txt
summary:
  The results indicate that by tailoring measures to specific subgroups, the overall number of CSSA recipients would be reduced, thereby improving the efficiency of Hong Kong’s social security system, which has accounted for more than 16.5% of Hong Kong government expenditure in 2018, amounting to more than HKD 92 billion. Leave no one behind is the overarching principle of the United Nations' It is important to consider whether the entering approach is indeed more effective than the leaving approach in reducing the number of CSSA recipients in Hong Kong.


id: cord-340028-6oicmeam
author: Zhavoronkov, Alex
date: 2020-03-31
extension: .txt
mime: text/plain
words: 7232
sentence: 280
flesch: 30
cache: cache/cord-340028-6oicmeam.txt
txt: txt/cord-340028-6oicmeam.txt
title:
  Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections

summary:
  However, it may be possible to conduct clinical trials on the efficacy of geroprotectors previously tested in human clinical trials in treating COVID-19 and other gerophilic and gerolavic infections. Substantial pre-clinical validation would be required to apply these compounds to specific age-associated diseases and to explore clinical applications of these compounds in human clinical trials.


id: cord-285546-5tjhdczt
author: Green, Manfred S.
date: 2020-10-21
extension: .txt
mime: text/plain
words: 2390
sentence: 123
flesch: 61
cache: cache/cord-285546-5tjhdczt.txt
txt: txt/cord-285546-5tjhdczt.txt
title:
  The confounded crude case-fatality rates (CFR) for COVID-19 hide more than they reveal—a comparison of age-specific and age-adjusted CFRs between seven countries

summary:
  Similarity in case fatality rates (CFR) of COVID-19/SARS-COV-2 in Italy and China Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy Early estimation of the case fatality rate of COVID-19 in mainland China: a data-driven analysis Potential biases in estimating absolute and relative case-fatality risks during outbreaks Covid-19: death rate is 0.66% and increases with age, study estimates Estimates of the severity of coronavirus disease 2019: a model-based analysis Aggiornamento nazionale The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19)-China, 2020. The age-adjusted CFRs were computed by the direct method, using the combined number of cases in all seven countries in each age group as the standard population.


id: cord-353600-5wo74ms4
author: Tyrrell, Daniel J.
title: Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6
date: 2020-09-11
extension: .txt
mime: text/plain
words: 8249
sentence: 274
flesch: 22
cache: cache/cord-353600-5wo74ms4.txt
txt: txt/cord-353600-5wo74ms4.txt
summary:
  Vascular cells such as vascular smooth muscle cells (VSMCs) have been shown in animal models to have an elevated IL6 production with ageing before any signs of atherosclerosis development 86, 87 . Finally, we propose that future experimental and clinical investigation will be required to determine the contribution of this inflamma tory pathway in age related atherosclerosis.


id: cord-322913-sq9mq6f1
author: Ciabattini, Annalisa
date: 2020-11-06
extension: .txt
mime: text/plain
words: 8078
sentence: 256
flesch: 24
cache: cache/cord-322913-sq9mq6f1.txt
txt: txt/cord-322913-sq9mq6f1.txt
title:
  Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population

summary:
  The immunogenicity of 7-valent pneumococcal conjugate vaccine versus 23-valent polysaccharide vaccine in adults aged 50-80 years Study of the effectiveness of influenza vaccination in the elderly in the epidemic of 1989-90 using a general practice database Effectiveness of influenza vaccine in the community-dwelling elderly Effect of influenza vaccine status on winter mortality in Spanish community-dwelling elderly people during 2002-2005 influenza periods Efficacy and costeffectiveness of influenza vaccination of the elderly in a densely populated and unvaccinated community Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination A single dose of unadjuvanted novel 2009 H1N1 vaccine is immunogenic and well tolerated in young and elderly adults Immune response following H1N1pdm09 vaccination: differences in antibody repertoire and avidity in young adults and elderly populations stratified by age and gender Role of the microbiota in the modulation of vaccine immune responses The influence of the intestinal microbiome on vaccine responses Antibiotics-driven gut microbiome perturbation alters immunity to vaccines in humans Recent advances in systems biology integrating clinical, immunologic, and omics data can help to identify stable and robust markers of vaccine response and move towards a better understanding of SARS-CoV-2 vaccine responses in the elderly.


id: cord-344713-jisp238l
author: Meyers, Keith
title: Can pandemics affect educational attainment? Evidence from the polio epidemic of 1916
date: 2020-07-27
extension: .txt
mime: text/plain
words: 8899
sentence: 366
flesch: 55
cache: cache/cord-344713-jisp238l.txt
txt: txt/cord-344713-jisp238l.txt
summary:
  We measure 1916 polio epidemic exposure by reported infections at the statelevel so that our main identifying assumption is that people who were school age in 1916 would be exposed in their state of birth. It attenuates the statistical significance of the 1916 epidemic for children ages 0 to 10 in 1916 in specifications (1) and (2) but strengthens it in specification (3).


id: cord-292024-ae7rauc6
author: Fulop, T.
title: Immunosenescence is both functional/adaptive and dysfunctional/maladaptive
date: 2020-09-15
extension: .txt
mime: text/plain
words: 10210
sentence: 420
flesch: 42
cache: cache/cord-292024-ae7rauc6.txt
txt: txt/cord-292024-ae7rauc6.txt
summary:
  At each aggression, innate immune cells such as monocytes are activated [58] The SASP phenotype elicits an autocrine role on senescent cells, but it is also involved in the recruitment of immune cells, such as macrophages, neutrophils, and natural killer (NK) cells in order to eliminate the senescent cells themselves [143] .


id: cord-329626-lsbny5to
author: Losada-Baltar, Andrés
date: 2020-04-13
extension: .txt
mime: text/plain
words: 3345
sentence: 118
flesch: 45
cache: cache/cord-329626-lsbny5to.txt
txt: txt/cord-329626-lsbny5to.txt
title:
  “We’re staying at home”. Association of self-perceptions of aging, personal and family resources and loneliness with psychological distress during the lock-down period of COVID-19

summary:
  Association of self-perceptions of aging, personal and family resources and loneliness with psychological distress during the lock-down period of COVID-19 date: 2020-04-13 journal: J Gerontol B Psychol Sci Soc Sci DOI: 10.1093/geronb/gbaa048 sha: doc_id: 329626 cord_uid: lsbny5to OBJECTIVES: In addition to specific questions about risk for COVID-19, self-perceptions of aging, family and personal resources, loneliness and psychological distress were measured.


id: cord-304365-al3p52uj
author: Egenvall, A.
title: Mortality of Life‐Insured Swedish Cats during 1999–2006: Age, Breed, Sex, and Diagnosis
date: 2009-09-22
extension: .txt
mime: text/plain
words: 4418
sentence: 207
flesch: 55
cache: cache/cord-304365-al3p52uj.txt
txt: txt/cord-304365-al3p52uj.txt
summary:
  Population-based figures on cat mortality and morbidity are limited. Birth and death rates estimates of cats and dogs in US households and related factors A study of risk factors for cat mortality in adoption centres of a UK cat charity Causes of death and disease in cats based on 1969-1982 post mortem statistics Comparative study of causes of death and life expectancy in carnivorous pets (II) Gender, age, breed and geographic pattern of morbidity and mortality in insured dogs during Mortality of Swedish horses with complete life insurance between 1997 and 2000 variations with sex, age, breed and diagnosis Diagnosregister fo¨r ha¨st, hund och katt (Diagnostic registry for the horse, the dog and the cat) Veterinary Epidemiolog Research, 1 st ed France: International Agency for Research on Cancer; 1987, 59.


id: cord-322704-0suc6pt6
author: Riffe, T.
title: COVeAGE-DB: A database of age-structured COVID-19 cases and deaths.
date: 2020-09-23
extension: .txt
mime: text/plain
words: 2904
sentence: 134
flesch: 49
cache: cache/cord-322704-0suc6pt6.txt
txt: txt/cord-322704-0suc6pt6.txt
summary:
  These studies aim t o: (i) explore country differences in the age distribution of COVID-19 deaths, 2 (ii) assess the contributi on of infection case age-structure and age-specific fatality to between-and within-country differences in case fatality rates (CFR) associated with the COVID-19, 3 (iii) produce a standard age-specific case fatality rate pattern for an indirect demographic method to estimate COVID-19 total infections, 4 (iv) analyze the association between intergenerational relationships and COVID-19 fatality rates, 5 (v) estimate years of life lost due to Covid-19, 6 and (vi) calculate pooled sex ratios of age-specific CFRs of COVID-19 in Europe. While most populations currently report all deaths to confirmed COVID-19 infections as COVID-19 deaths for this database, the underlying cause of death eventually reported on death certificates may differ in patients with severe comorbidities.


id: cord-305475-lhi0hcki
author: Risku, Minna
title: Human bocavirus types 1, 2 and 3 in acute gastroenteritis of childhood
date: 2012-05-24
extension: .txt
mime: text/plain
words: 3585
sentence: 144
flesch: 52
cache: cache/cord-305475-lhi0hcki.txt
txt: txt/cord-305475-lhi0hcki.txt
summary:
  Cloning of a human parvovirus by molecular screening of respiratory tract samples Human bocavirus and acute wheezing in children Human bocavirus infection in children with respiratory tract disease Human bocavirus in children: mono-detection, high viral load and viraemia are associated with respiratory tract infection Serodiagnosis of human bocavirus infection Human bocavirus infections in hospitalized children and adults Clinical and epidemiologic characteristics of human bocavirus in danish infants: results from a prospective birth cohort study Frequent and prolonged shedding of bocavirus in young children attending daycare Human bocavirus infection in children with acute gastroenteritis in Japan and Thailand Human bocavirus, a respiratory and enteric virus Human bocavirus infection in children hospitalized with acute gastroenteritis in China Detection of human bocavirus in children hospitalized because of acute gastroenteritis Human bocavirus in children hospitalized for acute gastroenteritis: a case-control study A novel bocavirus associated with acute gastroenteritis in Australian children A newly identified bocavirus species in human stool Human bocaviruses are highly diverse, dispersed, recombination prone, and prevalent in enteric infections Development of a real-time PCR assay for detecting and quantifying human bocavirus 2 Detection of human bocavirus-2 in children with acute gastroenteritis in South Korea Real-time quantitative PCR detection of four human bocaviruses High prevalence of human bocavirus 2 and its role in childhood acute gastroenteritis in China Detection of human bocavirus 3 in China Again, co-infections with known human gastroenteritis viruses have commonly been found (18, 20) as well as shedding in stools of asymptomatic children (20) .


id: cord-309809-zvh2k97q
author: Knepple Carney, Amy
title: Age Moderates Perceived COVID-19 Disruption on Well-being
date: 2020-08-18
extension: .txt
mime: text/plain
words: 3251
sentence: 121
flesch: 50
cache: cache/cord-309809-zvh2k97q.txt
txt: txt/cord-309809-zvh2k97q.txt
summary:
  Older adults showed the highest levels of resilience following the September 11(th) (9/11) terrorist attacks, but during the severe acute respiratory syndrome (SARS) outbreak there were no age-related differences in well-being. Findings are consistent with the strength and vulnerability integration (SAVI) model, wherein older adults try to maintain positive emotional well-being; with middle-aged and older adults in the current study having experienced less negative impact on well-being.


id: cord-294180-t5bncpo4
author: Neto, Leônidas Oliveira
title: Aging and Coronavirus: Exploring Complementary Therapies to Avoid Inflammatory Overload
date: 2020-06-26
extension: .txt
mime: text/plain
words: 3503
sentence: 102
flesch: 24
cache: cache/cord-294180-t5bncpo4.txt
txt: txt/cord-294180-t5bncpo4.txt
summary:
  Furthermore, reducing sedentary behavior and engaging in exercise may increasing the production of systemic anti-inflammatory cytokines and help to combat inflammation (63, 64) by increasing innate immune function (65) and decreasing the chronic inflammation related to various diseases (66) . Adipose tissue: immune function and alterations caused by obesity Endocrine and metabolic link to coronavirus infection Kidney disease is associated with in-hospital death of patients with COVID-19 Similarity in case fatality rates (CFR) of COVID-19/SARS-COV-2 in Italy and China Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China Diagnosis and clinical management of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection: an operational recommendation of Peking Union Medical College Hospital (V2.0): Working Group Novel Coronavirus, Peking Union Medical Colle Interacting mediators of allostasis and allostatic load: towards an understanding of resilience in aging Allostasis and allostatic load: expanding the discourse on stress and cardiovascular disease Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies Associations between immune-suppressive and stimulating drugs and novel COVID-19-a systematic review of current evidence Metronidazole a potential novel addition to the COVID-19 treatment regimen The use of antiinflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): the experience of clinical immunologists from China The role of oxidative stress in the aging process Inflammation, genetic background and longevity Clinical advances in sex-and gender-informed medicine to improve the health of all: a review The lethal sex gap: COVID-19 24.


id: cord-267664-vahd59z8
author: Cesari, Matteo
title: COVID-19 in Italy: Ageism and Decision-Making in a Pandemic
date: 2020-04-01
extension: .txt
mime: text/plain
words: 1665
sentence: 68
flesch: 48
cache: cache/cord-267664-vahd59z8.txt
txt: txt/cord-267664-vahd59z8.txt
summary:
  Documento condiviso per una pianificazione delle scelte di cura Prognostic indices for older adults: a systematic review The central role of prognosis in clinical decision making Frailty and multimorbidity: different ways of thinking about geriatrics Evidence for The Domains Supporting The Construct of Intrinsic Capacity A global clinical measure of fitness and frailty in elderly people A Diagnosis of Dismobility-Giving Mobility Clinical Visibility: A Mobility Working Group Recommendation A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men It is noteworthy that during the early crisis, the Società Italiana di Anestesia, Analgesia, Rianimazione e Terapia Intensiva (SIAARTI; Italian Society of Anesthesia, Analgesia, and Intensive Care) released clinical ethics recommendations for the allocation of treatment in exceptional resource-limited situations.


id: cord-317583-jhulvfev
author: Blanchflower, David G.
title: Is happiness U-shaped everywhere? Age and subjective well-being in 145 countries
date: 2020-09-09
extension: .txt
mime: text/plain
words: 12067
sentence: 538
flesch: 64
cache: cache/cord-317583-jhulvfev.txt
txt: txt/cord-317583-jhulvfev.txt
summary:
  These answers seem to be similar using happiness or life satisfaction data. Finally, I re-estimate the well-being equation and replace the age and age squared term with a complete set of single year of age variables which I then plot in a series of figures.


id: cord-259971-e3h8pr1v
author: Nwachukwu, Izu
title: COVID-19 Pandemic: Age-Related Differences in Measures of Stress, Anxiety and Depression in Canada
date: 2020-09-01
extension: .txt
mime: text/plain
words: 3994
sentence: 141
flesch: 43
cache: cache/cord-259971-e3h8pr1v.txt
txt: txt/cord-259971-e3h8pr1v.txt
summary:
  In the severe acute respiratory syndrome (SARS) outbreak in Taiwan during late April to mid-May 2003, a relationship between age and the development of psychological symptoms was reported, with younger age groups at higher risk This was a cross-sectional survey exploring the mean differences of perceived stress, anxiety, and depression symptom scores among subscribers of various age categories who enrolled in the Text4Hope program.


id: cord-315992-jxxio17w
author: Borja-Gonzalez, Maria
title: Aging Science Talks: The role of miR-181a in age-related loss of muscle mass and function
date: 2020-07-08
extension: .txt
mime: text/plain
words: 3035
sentence: 129
flesch: 34
cache: cache/cord-315992-jxxio17w.txt
txt: txt/cord-315992-jxxio17w.txt
summary:
  Negatively Regulates Myogenesis during Aging Using computer simulation models to investigate the most promising microRNAs to improve muscle regeneration during aging Divergent effects of miR-181 family members on myocardial function through protective cytosolic and detrimental mitochondrial microRNA targets Predicting effective microRNA target sites in mammalian mRNAs Molecular mechanisms of pathogenesis in hepatocellular carcinoma revealed by RNA-sequencing MiR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes Role of the microRNA 181 family in glioma development Echocardiography and Vascular Ultrasound: New Developments and Future Directions IL-6: A potential role in cardiac metabolic homeostasis miR-181a/b downregulation exerts a protective action on mitochondrial disease models The role of microRNA-181a in myocardial fibrosis following myocardial infarction in a rat model miR-181a regulates p62/SQSTM1, parkin, and protein DJ-1 promoting mitochondrial dynamics in skeletal muscle aging miR-181a Regulates Inflammation Responses in Monocytes and Macrophages MiR-181a and inflammation: MiRNA homeostasis response to inflammatory stimuli in vivo miRNA in the regulation of skeletal muscle adaptation to acute endurance exercise in C57BI/6J male mice The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation MicroRNA-181a/b-1 overexpression enhances osteogenesis by modulating PTEN/PI3K/AKT signaling and mitochondrial metabolism The impact of aging, physical activity, and pre-frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men Maintenance of Skeletal Muscle Mitochondria in Health, Exercise, and Aging Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass Signalling pathways regulating muscle mass in aging skeletal muscle. Association between muscular strength and mortality in men: Prospective cohort study Shared molecular and cellular mechanisms of premature aging and aging-associated diseases Impaired proteostasis during skeletal muscle aging Weight stability masks sarcopenia in elderly men and women The hallmarks of aging Systematic analysis of the gerontome reveals links between aging and age-related diseases Dynamics of life expectancy and life span equality SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients Why does COVID-19 disproportionately affect the elderly? COVID-19 in Older People: A Rapid Clinical Review Age, comorbidity, frailty status: effects on disposition and resource allocation during the COVID-19 pandemic Musculoskeletal Consequences of COVID-19 Sarcopenia: Aging-related loss of muscle mass and function Epidemiology and consequences of sarcopenia Treatment of sarcopenia: The road to the future MicroRNAs as potential therapeutic targets for muscle wasting during cancer cachexia Aging in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression Sarcopenia: Aging-related loss of muscle mass and function Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness Single Muscle Fiber Proteomics Reveals Fiber-Type-Specific Features of Human Muscle Aging Identification of a molecular signature of sarcopenia Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids Aging and microRNA expression in human skeletal muscle: A microarray and bioinformatics analysis The functional consequences of age-related changes in microRNA expression in skeletal muscle Most mammalian mRNAs are conserved targets of microRNAs MicroRNAs: Modulators of the underlying pathophysiology of sarcopenia? microRNAs in skeletal muscle differentiation and disease Expression patterns of muscle-specific miR-133b and miR-206 correlate with nutritional status and sarcopenia Involvement of MicroRNAs in the regulation of muscle wasting during catabolic conditions miR-26a is required for skeletal muscle differentiation and regeneration in mice Maintenance of muscle stem-cell quiescence by microRNA-489 Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling Age-related changes in miR-143-3p: Igfbp5 interactions affect muscle regeneration Inflamma-miR-21


id: cord-264811-xbeipob9
author: Choi, Yongin
date: 2020-10-14
extension: .txt
mime: text/plain
words: 6332
sentence: 244
flesch: 52
cache: cache/cord-264811-xbeipob9.txt
txt: txt/cord-264811-xbeipob9.txt
title:
  Assessment of Social Distancing for Controlling COVID-19 in Korea: An Age-Structured Modeling Approach

summary:
  Table 1 shows the incidence data by age group and the sources of infection in the target area during the period. More precisely, the location-specific contact matrix M is written as [25] where each element m ij denotes the mean number of contacts an individual in age group i makes with individuals in age group j per day.


id: cord-309556-xv3413k1
author: Chow, Ryan D.
title: The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2
date: 2020-04-15
extension: .txt
mime: text/plain
words: 5772
sentence: 206
flesch: 41
cache: cache/cord-309556-xv3413k1.txt
txt: txt/cord-309556-xv3413k1.txt
summary:
  Lung epithelial cells, macrophages, and Th1 cells decrease in abundance with age, whereas fibroblasts, pericytes and CD4+ Tcm cells increase in abundance with age. We showed that lung epithelial cells, macrophages, and Th1 cells decrease in abundance with age, whereas fibroblasts and pericytes increase in abundance with age.


id: cord-274546-jswt3pun
author: griette, q.
title: Unreported cases for Age Dependent COVID-19 Outbreak in Japan
date: 2020-05-12
extension: .txt
mime: text/plain
words: 4869
sentence: 244
flesch: 59
cache: cache/cord-274546-jswt3pun.txt
txt: txt/cord-274546-jswt3pun.txt
summary:
  The transmission matrix is the following where the matrix φ describes contacts and is given in (2.18) , and the transmission rates are the ones fitted to the data as in Figure 9 τ During the early stages of the epidemic, the transmission seems to be evenly distributed among age classes, with a little bias towards younger age classes (Figure 10 (a) ). The age distribution of the infected population is represented in Figure 1 and compared to the total population per age class (data from the Statistics Bureau of Japan estimate for October 1, 2019).


id: cord-103337-a1yidr4y
author: Aleta, A.
date: 2020-11-13
extension: .txt
mime: text/plain
words: 1520
sentence: 59
flesch: 54
cache: cache/cord-103337-a1yidr4y.txt
txt: txt/cord-103337-a1yidr4y.txt
title:
  Age differential analysis of COVID-19 second wave in Europe reveals highest incidence among young adults

summary:
  Here, we analyze data of incidence by age groups in 25 European countries, revealing that the highest incidence of the current second wave is observed for the group comprising young adults (aged 18-29 years old) in all but 3 of the countries analyzed. An analysis of the incidence by age group in one of these regions -Aragon, see Figure 1 -shows that in early summer the disease spread mainly within the 15-24 and 25-34 age groups.


id: cord-291184-uza4orb8
author: Lyra, Wladimir
date: 2020-04-14
extension: .txt
mime: text/plain
words: 3449
sentence: 175
flesch: 61
cache: cache/cord-291184-uza4orb8.txt
txt: txt/cord-291184-uza4orb8.txt
title:
  COVID-19 pandemics modeling with SEIR(+CAQH), social distancing, and age stratification. The effect of vertical confinement and release in Brazil.

summary:
  The effect of vertical confinement and release in Brazil. date: 2020-04-14 journal: nan DOI: 10.1101/2020.04.09.20060053 sha: doc_id: 291184 cord_uid: uza4orb8 The ongoing COVID-19 epidemics poses a particular challenge to low and middle income countries, making some of them consider the strategy of vertical confinement.


id: cord-254896-e6k1bp9n
author: Posch, Martin
title: Analysis of Austrian COVID-19 deaths by age and sex
date: 2020-07-03
extension: .txt
mime: text/plain
words: 2010
sentence: 88
flesch: 56
cache: cache/cord-254896-e6k1bp9n.txt
txt: txt/cord-254896-e6k1bp9n.txt
summary:
  But also in Austria, increased death rates, especially among the elderly, have been reported recently [8] . If we compare this normal mortality risk with the COVID-19 mortality until 31 March or 21 April, respectively ( Fig. 2a and b) , we see a similar increase (although the number of COVID-19 deaths registered by the respective survey date scaled to the population size is orders of magnitude lower than the annual mortality rates).


id: cord-260797-tc3pueow
author: Aleta, Alberto
title: Data-driven contact structures: From homogeneous mixing to multilayer networks
date: 2020-07-16
extension: .txt
mime: text/plain
words: 6337
sentence: 251
flesch: 46
cache: cache/cord-260797-tc3pueow.txt
txt: txt/cord-260797-tc3pueow.txt
summary:
  As a consequence, in these studies, superspreading events cannot occur naturally, unless the model is modified, contrary to network models in which the large connectivity of some individuals can result in the appearance of such events. This is especially relevant when going from classical mixing models to network models.


id: cord-262954-saqo900k
author: Esme, Mert
title: Older Adults With Coronavirus Disease 2019; A Nationwide Study in Turkey
date: 2020-09-01
extension: .txt
mime: text/plain
words: 4863
sentence: 201
flesch: 51
cache: cache/cord-262954-saqo900k.txt
txt: txt/cord-262954-saqo900k.txt
summary:
  In univariate regression, these geriatric syndromes increase mortality risk in COVID-19 patients. Front Public Health Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis Epidemiology of Covid-19 in a Long-Term Care Facility in King County Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults Changes in hypertension prevalence, awareness, treatment, and control rates in Turkey from Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region COVID-19 spiraling of frailty in older Italian patients Frailty index predicts poor outcome in COVID-19 patients.


id: cord-296494-6kn4mr04
author: Saban-Ruiz, J.
date: 2020-05-12
extension: .txt
mime: text/plain
words: 6450
sentence: 213
flesch: 39
cache: cache/cord-296494-6kn4mr04.txt
txt: txt/cord-296494-6kn4mr04.txt
title:
  COVID-19: A Personalized Cardiometabolic Approach for Reducing Complications and Costs. The Role of Aging Beyond Topics

summary:
  Even more interesting, taking into account that at least 50% of COVID-19 patients have hyperglycaemia on admission or in the first days of hospitalization (25) , the transmembrane domain has a potential N-glycation site (26) that in COVID-19 would deserve further research. COVID-19 patients who develop myocardial injury, usually DM and/or elderly patients, have a more acute presentation, with higher incidence of ADSR and more frequent need for assisted ventilation than those without myocardial injury (64) .


id: cord-324635-27q3nxte
author: Bouza, Emilio
title: The situation of infection in the elderly in Spain: a multidisciplinary opinion document
date: 2020-09-08
extension: .txt
mime: text/plain
words: 15951
sentence: 625
flesch: 42
cache: cache/cord-324635-27q3nxte.txt
txt: txt/cord-324635-27q3nxte.txt
summary:
  In a study conducted in China, in 6 sentinel hospitals, it was observed that 31.64% of elderly patients with respiratory infection had a viral aetiology (41.8% among extra-hospital infections and 25.7% among fecting the elderly vary depending on the clinical environment (home, nursing home, hospital) and the functional status of the patient. It is interesting to note the safety of using the same therapeutic options in elderly patients, including faecal microbiota transplantation [29, 30] .


id: cord-257765-ljt9rn8z
author: Ghisolfi, Selene
title: Predicted COVID-19 fatality rates based on age, sex, comorbidities and health system capacity
date: 2020-09-09
extension: .txt
mime: text/plain
words: 3989
sentence: 140
flesch: 43
cache: cache/cord-257765-ljt9rn8z.txt
txt: txt/cord-257765-ljt9rn8z.txt
summary:
  ► Using variation in demographics, comorbidities and health system capacity, we predict COVID-19 IFRs for 187 countries, ranging from 0.43% in Western Sub-Saharan Africa to 1.45% in Eastern Europe. However, the wide gap in childhood respiratory tract IFRs of between 2.8-fold and 7.4-fold between income groups has implications for COVID-19 IFRs that are too large to ignore.


id: cord-315126-713k0b9u
author: Rudolph, Cort W.
date: 2020-09-04
extension: .txt
mime: text/plain
words: 16399
sentence: 518
flesch: 27
cache: cache/cord-315126-713k0b9u.txt
txt: txt/cord-315126-713k0b9u.txt
title:
  Generations and Generational Differences: Debunking Myths in Organizational Science and Practice and Paving New Paths Forward

summary:
  Applying these ideas, the adoption of generations, and the accompanying prescriptions that clearly lay out how members of such generations ought to think and behave, helps people to make sense of why relatively older versus younger people are the way that they are. Moreover, this idea assumes that epochal events actually matter for the formation of distinct generations, a key argument in generations theory that is by-and-large untested, and indeed untestable.


id: cord-305743-rnfn6opa
author: Anton, Stephen D.
title: Innovations in Geroscience to enhance mobility in older adults
date: 2020-10-22
extension: .txt
mime: text/plain
words: 15996
sentence: 582
flesch: 32
cache: cache/cord-305743-rnfn6opa.txt
txt: txt/cord-305743-rnfn6opa.txt
summary:
  The American journal of medicine The association between objectively measured sitting and standing with body composition: a pilot study using MRI Associations of physical activity and sedentary behavior with regional fat deposition Reduced physical activity increases intermuscular adipose tissue in healthy young adults Sedentary behavior, physical activity, and the metabolic syndrome among U.S. adults Low muscle mass in older men: the role of lifestyle, diet and cardiovascular risk factors Physical activity prevented functional decline among frail community-living elderly subjects in an international observational study Obesity and mobility disability in the older adult Decreased functional capacity and muscle strength in elderly women with metabolic syndrome Prevalence of Metabolic Syndrome and Its Association with Physical Capacity, Disability, and Self-Rated Health Among Lifestyle Interventions for Elders (LIFE) Study Participants Sedentary and physically active behavior patterns among low-income African-American and white adults living in the southeastern United States The independent and combined associations of physical activity and sedentary behavior with obesity in adults: NHANES 2003-06 Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations--The LIFE Study Why sleep is important for health: a psychoneuroimmunology perspective Prevalence of Healthy Sleep Duration among Adults--United States Sleep and Human Aging Frequent napping is associated with excessive daytime sleepiness, depression, pain, and nocturia in older adults: findings from the National Sleep Foundation '2003 Sleep in America' Poll Longitudinal relationship between sleep deficiency and pain symptoms among community-dwelling older adults in Japan and Singapore Cortical thickness mediates the association between self-reported pain and sleep quality in community-dwelling older adults Chronic Musculoskeletal Pain Moderates the Association between Sleep Quality and Dorsostriatal-Sensorimotor Resting State Functional Connectivity in Community-Dwelling Older Adults The National Institute on Aging Health Disparities Research Framework Effects of stress throughout the lifespan on the brain, behaviour and cognition Social Isolation and Loneliness in Older Adults: Opportunities for the Health Care System Associations between social isolation, loneliness, and objective physical activity in older men and women Social isolation, loneliness, and all-cause mortality in older men and women Social isolation, loneliness and health in old age: a scoping review Where we live: health care in rural vs urban America Differential access to care: The role of age, insurance, and income on race/ethnicity-related disparities in adult perforated appendix admission rates National dissemination of multiple evidence-based disease prevention programs: reach to vulnerable older adults Ethnicity-and socio-economic status-related stresses in context: an integrative review and conceptual model Determinants of Adherence in Time-Restricted Feeding in Older Adults: Lessons from a Pilot Study Older Adults' Perceptions of Mobility: A Metasynthesis of Qualitative Studies Frailty Phenotype: Evidence of Both Physical and Mental Health Components in Community-Dwelling Early-Old Adults Balance Confidence and Fear of Falling Avoidance Behavior Are Most Predictive of Falling in Older Adults: Prospective Analysis Self-efficacy, pain, and quadriceps capacity at baseline predict changes in mobility performance over 2 years in women with knee osteoarthritis Falls efficacy as a measure of fear of falling Dizziness and its association with walking speed and falls efficacy among older men and women in an urban population Falls and fear of falling: which comes first? A longitudinal prediction model suggests strategies for primary and secondary prevention Mobility device use in older adults and incidence of falls and worry about falling: findings from the 2011-2012 national health and aging trends study Effects of supervised slackline training on postural instability, freezing of gait, and falls efficacy in people with Parkinson's disease A Backward Walking Training Program to Improve Balance and Mobility in Acute Stroke: A Pilot Randomized Controlled Trial Integrated primary and geriatric care for frail older adults in the community: Implementation of a complex intervention into real life Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss One-Year Adherence to the Otago Exercise Program With or Without Motivational Interviewing in Community-Dwelling Older Adults Walking can be more effective than balance training in fall prevention among community-dwelling older adults The Effect of Yoga on Balance and Fear of Falling in Older Adults Motivating Older Adults with Cancer to Keep Moving: the Implications of Lifestyle Interventions on Physical Activity Attitudes and needs of residents in long-term care facilities regarding physical activity-A systematic review and synthesis of qualitative studies Enablers and barriers to older people's participation in strength and balance activities: A review of reviews Integrated care for geriatric frailty and sarcopenia: a randomized control trial The retardation of aging by caloric restriction: studies in rodents and primates Dietary restriction and lifespan: Lessons from invertebrate models Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans Calorie restriction or exercise: effects on coronary heart disease risk factors.


id: cord-288392-khjo6j8u
author: Davern, Melanie
date: 2020-10-21
extension: .txt
mime: text/plain
words: 8982
sentence: 321
flesch: 31
cache: cache/cord-288392-khjo6j8u.txt
txt: txt/cord-288392-khjo6j8u.txt
title:
  How Can the Lived Environment Support Healthy Ageing? A Spatial Indicators Framework for the Assessment of Age-Friendly Communities

summary:
  These include consultation and engagement with local older people themselves to expand understanding, prioritise actions, and support the greatest social and economic benefits and returns on investments that support improved health and quality of life for older people. The WHO Age-Friendly Cities Framework Best practice principles for community indicator systems and a case study analysis: How community indicators Victoria is creating impact and bridging policy, practice and research Age-friendly cities and communities: Access to services for older people Developing a research and practice tool to measure walkability: A demonstration project Transport Walkability Index: Melbourne.


id: cord-031494-uvxb0ak9
author: Lamming, Dudley W.
title: Introduction: Special Issue on Aging Science Talks: Science for our Community During Isolation
date: 2020-09-06
extension: .txt
mime: text/plain
words: 448
sentence: 12
flesch: 30
cache: cache/cord-031494-uvxb0ak9.txt
txt: txt/cord-031494-uvxb0ak9.txt
summary:
  key: cord-031494-uvxb0ak9 authors: Lamming, Dudley W.; Carter, Christy S. title: Introduction: Special Issue on Aging Science Talks: Science for our Community During Isolation date: 2020-09-06 journal: Transl Med Aging DOI: 10.1016/j.tma.2020.09.001 sha: doc_id: 31494 cord_uid: uvxb0ak9 nan on the creation of Aging Science Talks, the lessons learned, and their thoughts on how conferences may change going forward as a result.


id: cord-280605-2i4gk7et
author: Bachmann, María Consuelo
date: 2020-10-14
extension: .txt
mime: text/plain
words: 11154
sentence: 327
flesch: 18
cache: cache/cord-280605-2i4gk7et.txt
txt: txt/cord-280605-2i4gk7et.txt
title:
  The Challenge by Multiple Environmental and Biological Factors Induce Inflammation in Aging: Their Role in the Promotion of Chronic Disease

summary:
  The impact on Tregulatory cell related immune responses in rural women exposed to polycyclic aromatic hydrocarbons (PAHs) in household air pollution in Gansu, China: A pilot investigation PM 2.5 induced pulmonary fibrosis in vivo and in vitro Blocking IL-17A Promotes the Resolution of Pulmonary Inflammation and Fibrosis Via TGF-b1-Dependent and -Independent Mechanisms Effects of sub-chronic exposure to atmospheric PM2.5 on fibrosis, inflammation, endoplasmic reticulum stress and apoptosis in the livers of rats Genetic and epigenetic alterations in normal and sensitive COPD-diseased human bronchial epithelial cells repeatedly exposed to air pollution-derived Effects of airborne pollutants on mitochondrial DNA Methylation Prenatal particulate air pollution and DNA methylation in newborns: An epigenomewide meta-analysis Dose-and time-effect responses of DNA methylation and histone H3K9 acetylation changes induced by traffic-related air pollution Air pollution and DNA methylation: Effects of exposure in humans Epigenetic response profiles into environmental epigenotoxicant screening and health risk assessment: A critical review Air pollution, particulate matter composition and methylation-based biologic age Air Pollution Stress and the Aging Phenotype: The Telomere Connection The effect of exposure time and concentration of airborne PM2.5 on lung injury in mice: A transcriptome analysis Facing up to the global challenges of ageing Coming of age: molecular drivers of aging and therapeutic opportunities Find the latest version: Review series introduction Coming of age: molecular drivers of aging and therapeutic opportunities Disability incidence and functional decline among older adults with major chronic diseases Quality of life assessment instruments for adults: a systematic review of population-based studies Comparative financing analysis and political economy of noncommunicable diseases The integration of inflammaging in age-related diseases Scavenger Receptor-A deficiency impairs immune response of microglia and astrocytes potentiating Alzheimer's disease pathophysiology Source of Chronic Inflammation in Aging Microglial cell dysregulation in brain aging and neurodegeneration Aging and the immune system: An overview Cellular senescence and Alzheimer disease: the egg and the chicken scenario The epigenetics of inflammaging: The contribution of age-related heterochromatin loss and locus-specific remodelling and the modulation by environmental stimuli These sex-related differences can determine the ability of immune cells to generate an effective inflammatory response, which translates into epidemiological differences on the prevalence of various pathologies, including allergies (22), asthma (23, 24), autoimmune diseases (25), anaphylaxis (26), neonatal sepsis (27), and cancer (28), among several pathologies.


id: cord-254339-djmibi3a
author: Griette, Quentin
title: Unreported Cases for Age Dependent COVID-19 Outbreak in Japan
date: 2020-06-17
extension: .txt
mime: text/plain
words: 5629
sentence: 323
flesch: 61
cache: cache/cord-254339-djmibi3a.txt
txt: txt/cord-254339-djmibi3a.txt
summary:
  As a consequence, unreported cases are a majority for young age classes (for age classes less than 50 years) and become a minority for older age classes (more than 50 years), see Figure 12 . In particular, we build a new mathematical model and a new computational method to fit the data by using age classes dependent exponential growth at the early stage of the epidemic.


id: cord-282839-3ii79g6j
author: Moreno-Fernández Ayala, Daniel J.
title: Age-related mitochondrial dysfunction as a key factor in COVID-19 disease
date: 2020-11-07
extension: .txt
mime: text/plain
words: 10253
sentence: 292
flesch: 20
cache: cache/cord-282839-3ii79g6j.txt
txt: txt/cord-282839-3ii79g6j.txt
summary:
  Further, T cell exhaustion associated with dendritic cell dysfunction has been also associated with the immunopathology of COVID-19 (Zheng et al., 2020a , Zheng et al., 2020b and an active role of local SARS-CoV-2 infected neutrophils and macrophages in inflammatory reactions has been recently proposed (Jafarzadeh et al., 2020) . This chronic inflammation has been associated with the inhibition of antigen-specific immunity and the low response of aged people to vaccines (Akbar and Gilroy, 2020; Parmigiani et al., 2013) .


id: cord-003244-abs3tc3r
author: Chong, Ka Chun
title: Monitoring the age-specificity of measles transmissions during 2009-2016 in Southern China
date: 2018-10-08
extension: .txt
mime: text/plain
words: 4847
sentence: 203
flesch: 48
cache: cache/cord-003244-abs3tc3r.txt
txt: txt/cord-003244-abs3tc3r.txt
summary:
  During 2000-2009, the number of measles cases showed a remarkable decrease but remained around 6.8 per 100,000 on average [2] . Daily notifications of measles cases from January 1, 2009 to December 31, 2016 were collected from the National Infectious Disease Monitoring Information System (NIDMIS), as complied by the Center for Disease Control and Prevention (CDC) of Guangdong Province.


id: cord-306210-ny3vvu9h
author: Clarfield, A. Mark
date: 2020-11-12
extension: .txt
mime: text/plain
words: 9583
sentence: 369
flesch: 52
cache: cache/cord-306210-ny3vvu9h.txt
txt: txt/cord-306210-ny3vvu9h.txt
title:
  Age, ageing, ageism and “age-itation” in the Age of COVID-19: rights and obligations relating to older persons in Israel as observed through the lens of medical ethics

summary:
  Without this aid it is difficult for such older persons to cope with social isolation and resulting loneliness. key: cord-306210-ny3vvu9h authors: Clarfield, A. Mark; Jotkowitz, Alan title: Age, ageing, ageism and “age-itation” in the Age of COVID-19: rights and obligations relating to older persons in Israel as observed through the lens of medical ethics date: 2020-11-12 journal:


id: cord-309161-ceahghs1
author: Epel, Elissa S.
title: The geroscience agenda: What does stress have to do with it?
date: 2020-09-28
extension: .txt
mime: text/plain
words: 7756
sentence: 259
flesch: 30
cache: cache/cord-309161-ceahghs1.txt
txt: txt/cord-309161-ceahghs1.txt
summary:
  It is not just stress responses to major events that matter. Cannon's stress studies led to the popular concept of homeostasis (Cannon, 1932) but a simple linear model of homeostasis does not explain the range of human stress responses, and there have been many elaborations of this concept.


id: cord-313218-4rbxdimf
author: Narushima, Miya
date: 2020-09-09
extension: .txt
mime: text/plain
words: 7199
sentence: 321
flesch: 55
cache: cache/cord-313218-4rbxdimf.txt
txt: txt/cord-313218-4rbxdimf.txt
title:
  “Fiercely independent”: Experiences of aging in the right place of older women living alone with physical limitations

summary:
  According to the 2015/2016 Canadian Community Health Survey, over one-third (35.4%) of people with home care needs did not have their needs met, especially among those with home support services for maintenance of daily living (Gilmour, 2018) . While aging in place has been a policy priority in rapidly greying Canada, a lack of complementary public supports poses challenges for many older adults and their family members.


id: cord-007084-4niom5mw
author: POPPLEWELL, PHILIP Y.
date: 1987-06-01
extension: .txt
mime: text/plain
words: 5311
sentence: 213
flesch: 36
cache: cache/cord-007084-4niom5mw.txt
txt: txt/cord-007084-4niom5mw.txt
title:
  The Influence of Age on Steroidogenic Enzyme Activities of the Rat Adrenal Gland: Enhanced Expression of Cholesterol Side-Chain Cleavage Activity(*)

summary:
  P-450SCC: substrate binding and kinetics of cholesterol side-chain oxidation Purification and characterization of mitochondrial cytochrome P-450 associated with cholesterol side-chain cleavage from bovine corpus luteum Inhibition of cholesterol side chain cleavage by active site directed antibody to corpus luteum cytochrome P450 The differential development of mitochondrial cytochrome P-450 and the respiratory cytochromes in rat ovary Intracellular movement of cholesterol in rat adrenal cells: kinetics and effects of inhibitors On the mechanism whereby ACTH and cyclic AMP increase adrenal polyphosphoinositides: rapid stimulation of the synthesis of phosphatidic acid and derivatives of CDP ~ diacylglycerol Phosphoinositide metabolism and hormone action Adrenocorticotropic hormone-mediated changes in rat adrenal mitochondrial phospholipids Sterol carrier protein 2 : delivery of cholesterol from adrenal lipid droplets to mitochondria for pregnenolone synthesis Sterol carrier protein 2 : identification of adrenal sterol carrier protein 2 and site of action for mitochondrial cholesterol utilization Intramitochondrial movement of adrenal sterol carrier protein with cholesterol in response to corticotropin Scallen TJ 1985 Phospholipid, sterol carrier protein 2 and adrenal steroidogenesis Polyphosphoinositide activation of cholesterol side chain cleavage with purified cytochrome P-4508CC Brownie AC i983 Cholesterol side-chain cleavage in the rat adrenal cortex: isolation of a cycloheximide-sensitive activator peptide Modulation of the kinetics of cholesterol side-chain cleavage by an activator and by an inhibitor isolated from the cytosol of the cortex of bovine .


id: cord-020694-zoy49483
author: Baig, Ulfat
title: Geriatric infections: Decreased immunity or evolved opportunists?
date: 2020-04-10
extension: .txt
mime: text/plain
words: 3226
sentence: 136
flesch: 43
cache: cache/cord-020694-zoy49483.txt
txt: txt/cord-020694-zoy49483.txt
summary:
  Alternatively, we compared age trends in the population mortality with those in incidence wherever available. Out of 9 pathogens, 6 had significantly decreasing age incidence curves.


id: cord-007088-yfdb594k
author: Coleman, Gerald L.
title: Pathological Changes During Aging in, Barrier-Reared Fischer 344 Male Rats(1)
date: 1977-05-17
extension: .txt
mime: text/plain
words: 5921
sentence: 324
flesch: 51
cache: cache/cord-007088-yfdb594k.txt
txt: txt/cord-007088-yfdb594k.txt
summary:
  Scattered single instances of hemorrhagic necrosis, ischemic malacia, atherosclerosis, and hemorrhage were present in other rats. The study also provided information on the feasibility of maintaining rats free of major intercurrent infection throughout their life-span in a commercial breeding environment and of shipping aged rats to investigators without significant mortality or stress.


id: cord-005097-6xkx9a56
author: Herndler-Brandstetter, Dietmar
title: Immunizations in the elderly: do they live up to their promise?
date: 2006
extension: .txt
mime: text/plain
words: 6404
sentence: 237
flesch: 35
cache: cache/cord-005097-6xkx9a56.txt
txt: txt/cord-005097-6xkx9a56.txt
summary:
  However, these pediatric VZV vaccines are not adequate in boosting T cell responses in older adults. But new and more potent candidate vaccines may have a beneficial effect by reducing morbidity and mortality due to boosting T cell responses in older adults.


id: cord-018387-ci5wx26t
author: Di Benedetto, Svetlana
title: Aging, Immunity, and Neuroinflammation: The Modulatory Potential of Nutrition
date: 2019-07-31
extension: .txt
mime: text/plain
words: 9573
sentence: 344
flesch: 26
cache: cache/cord-018387-ci5wx26t.txt
txt: txt/cord-018387-ci5wx26t.txt
summary:
  Chronic exposure to inflammatory mediators may disrupt the endothelial barrier and allow for the transfer of immune cells and numerous pro-inflammatory cytokines into the brain parenchyma that, in turn, can modulate microglial phenotype and reactivity and drive low-grade brain inflammation. Chronic exposure to inflammatory mediators may disrupt the endothelial barrier and allow for the transfer of immune cells and numerous pro-inflammatory cytokines into the brain parenchyma that, in turn, can modulate microglial phenotype and reactivity and drive low-grade brain inflammation.


id: cord-016903-z2vqfq98
author: Herndler-Brandstetter, Dietmar
title: The Efficacy of Vaccines to Prevent Infectious Diseases in the Elderly
date: 2007
extension: .txt
mime: text/plain
words: 6554
sentence: 235
flesch: 27
cache: cache/cord-016903-z2vqfq98.txt
txt: txt/cord-016903-z2vqfq98.txt
summary:
  An evolutionary perspective on immunosenescence Lack of antibody produ ction following immunization in old age: association with CD8 +CD28' T-cell clonal expansions and an imbalance in the production of Thl and Th2 cyrokines Restoration of viral immunity in immunodeficient humans by the adoptive transfer ofT-cell clones The epidemiology of pertussis: a comparison of the epidemiology of the disease pertussis with the epidemiology of Bordetella pertussis infection An epidemic of pertussis among elderly people in a religious institution in The Netherlands Vaccination against tetanus in the elderly: do recommended vaccination strategies give sufficient protection No immunity for the elderly A population-based serologic survey of immunity to tetanus in the United States T-cells from elderly persons respond to neoantigenic stimulation with an unimpaired IL-2 production and an enhanced differentiation into effector cells Epidemiology and ecology of TBE relevant to the production of effectivevaccines TBE vaccination and the Austrian experience Vaccine Immunogenicity and safety of a booster vaccination against tick-borne encephalitis more than 3 years following the last immunisation Epidemiology and prevention of hepatitis A in travelers Hepatitis A and hepatitis B: risks compared with other vaccine preventable diseases and immunization recommendations A prospective,randomized, comparative US trial of a combination hepatitis A and B vaccine (Twinrix) with corresponding monovalent vaccines (Havrix and Engerix-B) in adults Immunogenicity of an inactivated hepatitis A vaccine in Dutch United Nations troops Immunogenicity of combined hepatitis A and B vaccine in elderly persons They display a high immunogenicity and a similar safety profile in elderly persons compared with inactivated influenza vaccines.


id: cord-002005-35c6mak0
author: Parker, Philip D.
date: 2016-02-08
extension: .txt
mime: text/plain
words: 7653
sentence: 292
flesch: 48
cache: cache/cord-002005-35c6mak0.txt
txt: txt/cord-002005-35c6mak0.txt
title:
  What Effect Did the Global Financial Crisis Have Upon Youth Wellbeing? Evidence From Four Australian Cohorts

summary:
  Age effects are concerned with how old an individual is, cohort effects are concerned with the shared experiences of those who grow up in a similar historical context, whereas period effects are concerned with the impact of particular events that occur at a given time in history (see Schoon, 2006; Yang, 2008) . As noted above, we thus make the assumption that cohort effects are negligible.


id: cord-142389-t5swlp04
author: Linden, Matthias
title: The foreshadow of a second wave: An analysis of current COVID-19 fatalities in Germany
date: 2020-10-12
extension: .txt
mime: text/plain
words: 3741
sentence: 174
flesch: 58
cache: cache/cord-142389-t5swlp04.txt
txt: txt/cord-142389-t5swlp04.txt
summary:
  To re-establish control, and to avoid the tipping point when TTI capacity is exceeded, case numbers have to be lowered. However, already the increasing case numbers put the mitigation strategy at risk, because with case numbers being too high, local tipping points are crossed, which makes the control increasingly difficult, impedes the targeted protection of the vulnerable people, and leads to self-accelerating spread [1, 2] .


id: cord-007303-wuuhlowd
author: Valkonen, Tarmo
title: The Finnish Pension System and Its Future Challenges
date: 2020-04-01
extension: .txt
mime: text/plain
words: 4066
sentence: 181
flesch: 51
cache: cache/cord-007303-wuuhlowd.txt
txt: txt/cord-007303-wuuhlowd.txt
summary:
  First, the liability to pay pension contributions, previously solely on employers, was partially shifted to employees. The guarantee pension, which defi nes the minimum amount of pension income, was introduced in 2011.


id: cord-029015-rn62sbfm
author: Guyonnet, Sophie
date: 2020-07-10
extension: .txt
mime: text/plain
words: 6095
sentence: 212
flesch: 38
cache: cache/cord-029015-rn62sbfm.txt
txt: txt/cord-029015-rn62sbfm.txt
title:
  The INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort)

summary:
  In this context, we need to develop researches to identify biomarkers of aging and healthy aging, and know how to measure biological aging. Tools will be implemented for data exploration and data sharing between INSPIRE consortium researches and later on with external scientists.


id: cord-274009-ew4diub5
author: Emerson, Kerstin Gerst
title: Coping with being cooped up: Social distancing during COVID-19 among 60+ in the United States
date: 2020-06-29
extension: .txt
mime: text/plain
words: 3914
sentence: 207
flesch: 59
cache: cache/cord-274009-ew4diub5.txt
txt: txt/cord-274009-ew4diub5.txt
summary:
  Perspectives on loneliness Loneliness as a public health issue: The impact of loneliness on health care utilization among older adults Older adult loneliness: myths and realities SARS control and psychological effects of quarantine Don't worry, be 80: Video calls were significantly more common among the younger respondents, with nearly 53.8% of older respondents saying the never used video calls, compared to 37.6% of younger respondents.


id: cord-035015-slgywe0c
author: Nunn, Alistair V. W.
title: SARS-CoV-2 and mitochondrial health: implications of lifestyle and ageing
date: 2020-11-09
extension: .txt
mime: text/plain
words: 14677
sentence: 507
flesch: 27
cache: cache/cord-035015-slgywe0c.txt
txt: txt/cord-035015-slgywe0c.txt
summary:
  Critically, it modulates mitochondrial function, having diverse affects depending on the tissue; it can stimulate muscle mitochondrial function [241] , but may also enhance lipid storage and adipogenesis [242] . As the immune system itself is heavily reliant on mitochondrial function, then maintaining a healthy mitochondrial system may play a key role in resisting the virus, both directly, and indirectly by ensuring a good vaccine response.


id: cord-263650-jxkjn8ld
author: Andruske, Cynthia Lee
title: Family care across diverse cultures: Re-envisioning using a transnational lens
date: 2020-10-20
extension: .txt
mime: text/plain
words: 9666
sentence: 383
flesch: 52
cache: cache/cord-263650-jxkjn8ld.txt
txt: txt/cord-263650-jxkjn8ld.txt
summary:
  This perspective challenges the dominant approach to studying family care in gerontology that generally conceptualizes family care practice as one local primary caregiver, often female, with some support from other family members. Second, in considering ethnicity and/or culture in family care, this body of knowledge has rarely focused on finding a meaningful way to examine the significant role that immigration and acculturation may have in implicating family care practices (Guo et al., 2019) .


id: cord-016301-vqmqnipq
author: Winnick, Aaron M.
title: Elderly Transplant Recipients
date: 2011-01-25
extension: .txt
mime: text/plain
words: 11468
sentence: 456
flesch: 38
cache: cache/cord-016301-vqmqnipq.txt
txt: txt/cord-016301-vqmqnipq.txt
summary:
  Age and immune response in organ transplantation Immunosuppression of the elderly kidney transplant recipient Rejection and recipient age Use of mycophenolate mofetil in immunosuppressive protocols in elderly renal transplant recipients Mycophenolate mofetil vs. azathioprine in a large population of elderly renal transplant patients Immunosuppression: evolution in practice and trends Risk factors for development of new-onset diabetes mellitus after kidney transplantation A calcineurin antagonist-free induction/maintenance strategy for immunosuppression in elderly recipients of renal allografts from elderly cadaver donors: long-term results from a prospective single centre trial Long-term results of calcineurin-free protocols with basiliximab induction in old-toold programs Preferential allocation of marginal kidney allografts to elderly recipients combined with modified immunosuppression gives good results Early mortality rates in older kidney recipients with comorbid risk factors Renal transplantation in the elderly: surgical complications and outcome with special emphasis on the Eurotransplant Senior Programme Liver transplantation trends for older recipients: regional and ethnic variations Chronic liver disease in the extremely elderly of 80 years or more: clinical characteristics, prognosis and patient survival analysis Liver transplantation in patients over sixty years of age Orthotopic liver transplantation in patients 60 years of age and older Orthotopic liver transplantation in patients over 60 years old Liver transplantation in patients over 60 years of age Liver transplantation in patients over sixty years of age Liver transplantation in patients over 60 and 65 years: an evaluation of long-term outcomes and survival Liver transplant for the septuagenarians: importance of patient selection Minimal criteria for placement of adults on the liver transplant waiting list: a report of a national conference organized by the American Society of Transplant Physicians and the American Association for the Study of Liver Diseases MELD and PELD: application of survival models to liver allocation Predicting outcome after liver transplantation: utility of the model for endstage liver disease and a newly derived discrimination function Impact of age older than 60 years in living donor liver transplantation Older age and liver transplantation: a review The prevalence of coronary artery disease in liver transplant candidates over age 50 The elderly liver transplant recipient: a call for caution Liver transplant recipients older than 60 years have lower survival and higher incidence of malignancy Allograft survival following adult-to-adult living donor liver transplantation Outcomes of 385 adult-to-adult living donor liver transplant recipients: a report from the A2ALL Consortium Long-term results of liver transplantation in older patients 60 years of age and older Liver transplantation in patients beyond age 60 Liver transplantation in recipients over 60 Similar outcomes, morbidity, and mortality for orthotopic liver transplantation between the very elderly and the young Evolution of liver transplantation in Europe: report of the European Liver Transplant Registry Prognostic model for early acute rejection after liver transplantation Age and liver transplantation: a report of the Liver Transplantation Database Transplantation in the elderly patient The registry of the International Society for Heart and Lung Transplantation: twentieth official adult heart transplant report -2003 Heart transplantation in patients seventy years of age and older: a comparative analysis of outcome Long-term survival (>10 years) of patients >60, years with induction therapy after cardiac transplantation Long-term results of heart transplantation in patients older than 60 years Outcomes in patients older than 60 years of age undergoing orthotopic heart transplantation: an analysis of the UNOS database Listing criteria for heart transplantation: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates -2006 Selection and treatment of candidates for heart transplantation. Heart transplantation in older candidates A comparative analysis of outcome after heart transplantation in patients aged 60 years and older: the University of Alberta experience Long-term outcomes of heart transplantation in older recipients Poor prognosis of heart transplant patients with end-stage renal failure Incidence of malignancies in heart and/or lung transplant recipients: a single-institution experience Registry of the International Society for Heart and Lung Transplantation: twentyfifth official adult lung and heart/lung transplantation report -2008 Assessment of survival benefit after lung transplantation by patient diagnosis Listing for lung transplantation: life expectancy and transplant effect, stratified by type of end-stage lung disease, the Eurotransplant experience International guidelines for the selection of lung transplant candidates: 2006 update -a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation Induction immunosuppression for lung transplantation with OKT3 Induction therapy in lung transplantation: a prospective, controlled clinical trial comparing OKT3, anti-thymocyte globulin, and daclizumab Registry of the International Society for Heart and Lung Transplantation: twentyfourth official adult lung and heart-lung transplantation report -2007 Impact of advanced age in lung transplantation: an analysis of United Network for Organ Sharing data Primary graft dysfunction and other selected complications of lung transplantation: a single-center experience of 983 patients Post-transplant bronchiolitis obliterans Development of malignancy following lung transplantation


id: cord-258093-6fn8ei9f
author: Hanania, Nicola A.
date: 2011-08-25
extension: .txt
mime: text/plain
words: 17068
sentence: 711
flesch: 41
cache: cache/cord-258093-6fn8ei9f.txt
txt: txt/cord-258093-6fn8ei9f.txt
title:
  Asthma in the elderly: Current understanding and future research needs—a report of a National Institute on Aging (NIA) workshop

summary:
  The aging lung Large, longitudinal, and more complete studies to determine the effects of aging on the function of the respiratory system Improved knowledge about lung structure-function relationships in older age using techniques of imaging and measures of lung function not requiring effort (eg, high-resolution computed tomographic scanning and forced oscillation) Improved assessment of lung processes underlying airflow limitation attributable to aging versus COPD or asthma, especially in asthmatic patients who smoke Studies to examine the effects of aging in ethnic groups and the role of gender Epidemiology, effect, diagnosis, and management Determine the true prevalence and cost of asthma in the older population Develop a uniform definition of asthma to be applied to health care records that will distinguish asthma from COPD and mixed asthma/COPD Evaluate evidence-based treatment algorithms for older asthmatic patients, such as those developed by the National Heart, Lung, and Blood Institute and Global Initiative For Asthma guidelines 7 Assess the effect of asthma treatment, including direct medical costs of care, indirect costs of care, and value of treatment in improving quality of life 8, 9 Assess the effect of comorbid conditions, especially COPD and congestive heart failure, on asthma 9 Characterize phenotypes of elderly asthma with regard to responses to therapy and long-term outcomes based on age of onset, duration of disease, and environmental triggers Develop algorithms for electronic medical record systems that are asthma-specific Evaluate effects of current asthma medications in older patients compared with younger patients Identify pharmacogenetic determinants of response to asthma medications in older adults Identify simpler and safer drug delivery systems and schedules for older adults Develop simple methods to differentiate COPD from asthma exacerbations in older adults Understand how environmental or aging-related factors affect epigenetic changes in asthma in older adults Identify differences between older and younger asthmatic patients or between LSA and LOA with regard to inflammation, remodeling, intracellular mechanisms, responses to environmental pollutants, and allergy sensitization and their effects on the metabolism and action of asthma drugs Identify naturally occurring age-related changes in airway cellular patterns Develop animal models of age-related airway inflammation Understand the significance of allergy sensitization associated with asthma in older adults (eg, through larger prospective studies) 97, 124, 128 Patients with LOA start having asthma symptoms for the first time when they are 65 years of age or older (some studies have suggested middle age or older).


id: cord-259012-rk0sd9i5
author: Mehta, Hemal
title: Trends in Real-World Neovascular AMD Treatment Outcomes in the UK
date: 2020-10-14
extension: .txt
mime: text/plain
words: 7106
sentence: 272
flesch: 42
cache: cache/cord-259012-rk0sd9i5.txt
txt: txt/cord-259012-rk0sd9i5.txt
summary:
  Eye (Lond) Visual outcomes of age-related macular degeneration patients undergoing intravitreal ranibizumab monotherapy in an urban population Long-term visual outcomes of intravitreal ranibizumab treatment for wet age-related macular degeneration and effect on blindness rates in south-east Scotland Long-term outcomes of intravitreal ranibizumab for neovascular age-related macular degeneration in a well defined region of the UK Bilateral visual outcomes and service utilization of patients treated for 3 years with ranibizumab for neovascular age-related macular degeneration Long-term outcomes of aflibercept treatment for neovascular age-related macular degeneration in a clinical setting One-and two-year visual outcomes from the moorfields age-related macular degeneration database: a retrospective cohort study and an open science resource Predicting visual outcomes in patients treated with aflibercept for neovascular age-related macular degeneration: data from a real-world clinical setting Comparison of two intravitreal ranibizumab treatment schedules for neovascular age-related macular degeneration Effectiveness of ranibizumab for neovascular age-related macular degeneration using clinician-determined retreatment strategy UK AMD/DR EMR REPORT IX: comparative effectiveness of predominantly as needed (PRN) ranibizumab versus continuous aflibercept in UK clinical practice Three-year visual outcome and injection frequency of intravitreal ranibizumab therapy for neovascular age-related macular degeneration Real-world visual outcomes in patients with neovascular age-related macular degeneration receiving aflibercept at fixed intervals as per UK licence Three-year follow-up of ranibizumab treatment of wet age-related macular degeneration: influence of baseline visual acuity and injection frequency on visual outcomes Visual acuity outcomes in ranibizumab-treated neovascular age-related macular degeneration; stratified by baseline vision First-year visual acuity outcomes of providing aflibercept according to the VIEW Study Protocol for age-related macular degeneration Bevacizumab for neovascular age related macular degeneration (ABC trial): multicentre randomised double masked study 24-month clinical outcomes of a treat-and-extend regimen with ranibizumab for wet age-related macular degeneration in a real life setting Factors affecting visual acuity after one year of follow up after repeated intravitreal ranibizumab for macular degeneration Resource use and real-world outcomes for ranibizumab treat and extend for neovascular age-related macular degeneration in the UK: interim results from TERRA Impact of injection frequency on 5-year real-world visual acuity outcomes of aflibercept therapy for neovascular age-related macular degeneration Realworld visual and clinical outcomes for patients with neovascular age-related macular degeneration treated with intravitreal ranibizumab: an 8-year observational cohort (AMD8) Second-year visual acuity outcomes of nAMD patients treated with aflibercept: data analysis from the UK Aflibercept Users Group. A meta-analysis was not carried out here, but if that is considered in a future analysis, the real-world studies would need to be weighted by number of study eyes and baseline characteristics adjusted for.


id: cord-253182-s60vzf3q
author: Fang, Evandro F.
date: 2020-09-21
extension: .txt
mime: text/plain
words: 23336
sentence: 711
flesch: 37
cache: cache/cord-253182-s60vzf3q.txt
txt: txt/cord-253182-s60vzf3q.txt
title:
  A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks

summary:
  Rapid ageing and an alarming increase in non-communicable diseases (NCDs) have arisen as major health concerns in China Marten et al., 2014) . Fourthly, a reform of the payment model used in elderly care services should be carried out, focusing on value rather than volume of care for populations at risk of care dependency.


id: cord-018449-4vdqq961
author: Norrie, Philip
title: How Disease Affected the End of the Bronze Age
date: 2016-06-26
extension: .txt
mime: text/plain
words: 13138
sentence: 501
flesch: 61
cache: cache/cord-018449-4vdqq961.txt
txt: txt/cord-018449-4vdqq961.txt
summary:
  Focusing on Ancient Near East, the Near East had the earliest Bronze Age because Metallurgy developed fi rst in Anatolia, modern Turkey. The next stage in human cultural development was the Iron Age; this is the third and fi nal stage in the usual three-stage sequence of Stone Age, Bronze Age and Iron Age or the fourth in the more detailed fi ve-stage sequence of Stone Age, Copper Age, Bronze Age, Iron Age and Steel Age.


id: cord-017916-wh708hes
author: Mocchegiani, Eugenio
date: 2008-08-04
extension: .txt
mime: text/plain
words: 12649
sentence: 356
flesch: 27
cache: cache/cord-017916-wh708hes.txt
txt: txt/cord-017916-wh708hes.txt
title:
  Role of Zinc and Selenium in Oxidative Stress and Immunosenescence: Implications for Healthy Ageing and Longevity

summary:
  redox independent functions Responses to mild cold stress are predicted by different individual characteristics in young and older subjects The enzymatic antioxidant system in blood and glutathione status in human immunodeficiency virus (HIV)-infected patients: effects of supplementation with selenium or beta-carotene Induction of cytokines by zinc ions in human peripheral blood mononuclear cells and separated monocytes RNA virus quasispecies: significance for viral disease and epidemiology Immunosenescence and the lung Beneficial effects of oral zinc supplementation on the immune response of old people The status of zinc, copper, and metallothionein in cancer patients Zinc transporters and the cellular trafficking of zinc Influenza-and respiratory syncytial virus-associated morbidity and mortality in the nursing home population Nutrition: impact on oral and systemic health Zinc, human diseases and aging Thymic hormone deficiency in normal ageing and Down's syndrome: is there a primary failure of the thymus? Effect of zinc supplementation on in vitro copper-induced oxidation of low-density lipoproteins in healthy French subjects aged 55-70 years: the Zenith Study Metallothionein disulfides are present in metallothioneinoverexpressing transgenic mouse heart and increase under conditions of oxidative stress Metallothionein transfers zinc to mitochondrial aconitase through a direct interaction in mouse hearts Selenium, systemic immune response syndrome, sepsis, and outcome in critically ill patients Zinc supplementation and plasma lipid peroxides in an elderly population The effect of zinc and vitamin A supplementation on immune response in an older population Zinc toxicity Roles for cell death in zinc deficiency Effect of zinc supply Zinc and immunoresistance to infection in aging: new biological tools Zinc, metallothioneins, immune responses, survival and ageing Reversibility of the thymic involution and of age-related peripheral immune dysfunctions by zinc supplementation in old mice Interrelationship among neutrophil efficiency, inflammation, antioxidant activity and zinc pool in very old age Regulation of matrix biology by matrix metalloproteinases Matrix metalloproteinases Postnatal regulation of ZnT-1 expression in the mouse brain Reactive oxygen species, antioxidants, and the mammalian thioredoxin system Selenium, zinc, and thyroid hormones in healthy subjects: low T3/T4 ratio in the elderly is related to impaired selenium status Effect of zinc ions on apoptosis in PBMCs from healthy aged subjects Rapid oxidation of DL-selenomethionine by peroxynitrite Metabolic age modelling: the lesson from centenarians Flow cytometric evaluation of the DNA profile and cell cycle of zinc supplemented human Chang liver cells Human immunosenescence: is it infectious? Effect of dietary selenium deficiency on incidence and size of 1,2-dimethylhydrazine-induced colon tumours in rats Lymphocyte response is enhanced by supplementation of elderly subjects with selenium-enriched yeast Hypopituitary dwarf and athymic nude mice and the study of the relationships among thymus, hormones, and aging Effects of zinc deficiency on Th1 and Th2 cytokine shifts Zinc deficiency in elderly patients Flow cytometric analysis of CD3/TCR complex, zinc, and glucocorticoid-mediated regulation of apoptosis and cell cycle distribution in thymocytes from old mice The importance of selenium to human health


id: cord-009713-sxd4t2tz
title: Poster Presentations
date: 2020-01-10
extension: .txt
mime: text/plain
words: 44058
sentence: 2401
flesch: 48
cache: cache/cord-009713-sxd4t2tz.txt
txt: txt/cord-009713-sxd4t2tz.txt
summary:
  Long-term safety and efficacy of adjunctive perampanel in paediatric patients (aged 4 to <12y) with partial-onset seizures (POS) or primary generalised tonic-clonic seizures (PGTCS) in Study 311 R FLAMINI 1 , A PATTEN 2 , LY NGO 3 1 Pediatric and Adolescent Neurodevelopmental Associates, Atlanta, GA, USA; 2 Eisai Ltd., Hatfield, Hertfordshire, UK; 3 Eisai Inc., Woodcliff Lake, NJ, USA Objective: Study 311 (NCT02849626) was a multicentre, openlabel, single-arm study of perampanel oral suspension (0.5mg/ mL) in paediatric patients (aged 4 to <12y) with POS (with/ without secondarily generalised seizures Here, we report long-term (1y) safety and efficacy data of adjunctive perampanel in paediatric patients from Study 311.


id: cord-015372-76xvzvdg
title: National scientific medical meeting 1996 abstracts
date: 1996
extension: .txt
mime: text/plain
words: 36628
sentence: 1882
flesch: 50
cache: cache/cord-015372-76xvzvdg.txt
txt: txt/cord-015372-76xvzvdg.txt
summary:
  Control patients were enrolled who had no clinical evidence of rheumatological disease, A salivary sample was collected and examined by light microscopy. Drug induced photosensitivity may look identical clinically, have a similar history and patients with CAD may be treated with potentially photosensitising drugs.


id: cord-022659-chwk2bs4
title: Abstracts: Poster session
date: 2004-10-08
extension: .txt
mime: text/plain
words: 49293
sentence: 2332
flesch: 47
cache: cache/cord-022659-chwk2bs4.txt
txt: txt/cord-022659-chwk2bs4.txt
summary:
  We conclude that this cingulate activation may reflect the greater involvement of an attentional network (of which the anterior cingulate is a part) in tasks requiring a higher degree of mental work on the part of AD patients. To investigate erythrocyte membrane molecular dynamics in AD patients and age-matched controls, we investigated erythrocyte membrane molecular motion at the surface (fluorescamine), aqueous-hydrocarbon interface (DPPE-ANS), and hydrocarbon core (1219j-AS; PPC-DPH) by steady-state fluorescence anisotropy measurements of 16 probable AD patients (5 males; 11 females) and 20 (1 1 males; 9 females) age-matched controls.


id: cord-005646-xhx9pzhj
date: 1996
extension: .txt
mime: text/plain
words: 72090
sentence: 3551
flesch: 51
cache: cache/cord-005646-xhx9pzhj.txt
txt: txt/cord-005646-xhx9pzhj.txt
title:
  2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme

summary:
  Objective: To assess the normal ,gastric intramucosal pH ~Hi) by tonometry in healthy children Patients and methods: Twelve healthy children (6 males and 6 females) with age rmaged from 6 months to 12 years scheduled for minor plastic or urologic surgery. Pain relief was good (VRS less 2) in 53 children -94.6 % of study patients.


id: cord-004675-n8mlxe7p
title: 2019 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference
date: 2019-02-26
extension: .txt
mime: text/plain
words: 86609
sentence: 4214
flesch: 43
cache: cache/cord-004675-n8mlxe7p.txt
txt: txt/cord-004675-n8mlxe7p.txt
summary:
  Background: Patients with primary immune deficiencies characterized by severe T lymphopenia and/or poor T cell function and patients posthematopoietic cell transplantation are at high risk of severe viral infections. In this study, we investigated effect of IL12R1 mutation in IL-12/IFNaxis by evaluation of patients whole blood cell response to IL-12 and IFN-, IL-12R1 expression in PBMCs and T cell blasts.


id: cord-011062-ukz4hnmy
title: Poster
date: 2020-03-11
extension: .txt
mime: text/plain
words: 88442
sentence: 4220
flesch: 49
cache: cache/cord-011062-ukz4hnmy.txt
txt: txt/cord-011062-ukz4hnmy.txt
summary:
  Greater grip strength was associated with lower % of body fat and higher % of muscle mass. Conclusion: Older adult patients hospitalized for hip fracture who had frailty, functional dependence, and social problems had significant adverse events at a general hospital in Lima, Peru.


id: cord-004894-75w35fkd
title: Abstract
date: 2006-06-14
extension: .txt
mime: text/plain
words: 92227
sentence: 4958
flesch: 48
cache: cache/cord-004894-75w35fkd.txt
txt: txt/cord-004894-75w35fkd.txt
summary:
  A marked interindividual variability in high risk patients is seen, but at present the basis for this variability is unclear and can not be explained solely by environmental factors. Conclusion and discussion: This study provides evidence for a role for genetic variation of MCP-1 gene in the occurrence of coronary collaterals in high risk patients.


id: cord-002774-tpqsjjet
title: Section II: Poster Sessions
date: 2017-12-01
extension: .txt
mime: text/plain
words: 83566
sentence: 3777
flesch: 48
cache: cache/cord-002774-tpqsjjet.txt
txt: txt/cord-002774-tpqsjjet.txt
summary:
  The CHIP framework drives the complex inter-relationships between community-hospital engagement, reciprocal capacity-building, integration initiatives, and community-based research and evaluation, to create an interconnected network of health care services. Those living in urban centers should have the best ava1l~b1hty, chmce, and access to a variety of health care services because of the distribution of health care services, fac1lmes, and health professionals in concentrated in urban centers.


id: cord-015324-y44sfr0c
title: Scientific Programme
date: 2007-09-01
extension: .txt
mime: text/plain
words: 197844
sentence: 10138
flesch: 49
cache: cache/cord-015324-y44sfr0c.txt
txt: txt/cord-015324-y44sfr0c.txt
summary:
  In the group I, consisted of 63 infants (35 males and 28 females) PCD increased during the time in 3,2% infants, remained unchanged in 11,1%, decreased in 14,3%, and disappeared in 71,4% patients. There was no significant difference between renal transplant patients and healthy controls in genotype distribution of allelic frequencies of IL-6, FAS and MCP-1 polymorphisms.


# url

id: cord-322913-sq9mq6f1
domain: www.nih.gov
url:
  https://www.nih.gov/newsevents/news-releases/nih-clinical-trial-investigationalvaccine-covid-19-begins)


id: cord-317583-jhulvfev
domain: www.information.dk
url:
  https://www.information.dk/udland/2019/12/new-data-reveals-serious-problems-with-the-eus-officialpublic-opinion-polls


id: cord-306210-ny3vvu9h
domain: www.economist.com
url:
  https://www.economist.com/international/2020/09/26/the-pandemic-is-plunging-millionsback-into-extreme-poverty)


# ent

id: cord-325722-ixozph19
sid: 67
eid: 1
type: DATE
entity:
  1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017


id: cord-306210-ny3vvu9h
sid: 335
eid: 1
type: PERSON
entity:
  https://www.economist.com/international/2020/09/26/the-pandemic-is-plunging-millionsback-into-extreme-poverty


id: cord-142389-t5swlp04
sid: 126
eid: 5
type: PERSON
entity:
  wöchentlich beobachteten fälle jeder altersgruppe um zwei wochen verzögern und mit der entsprechenden


id: cord-324635-27q3nxte
sid: 581
eid: 13
type: ORG
entity:
  la asistencia en los servicios de urgencias de hospitales españoles saturación de los servicios de urgencias


id: cord-002774-tpqsjjet
sid: 3320
eid: 12
type: ORG
entity:
  caracterizandolos y diferenciandolos en tanto constitutivos de identidades socia les que condicionan la implementaci6n del programas de reduccion de daiios.resultados:


# pos

id: cord-322913-sq9mq6f1
sid: 170
tid: 1
pos: NOUN
token:
  https://www.nih.gov/newsevents/news-releases/nih-clinical-trial-investigationalvaccine-covid-19-begins

lemma:
  https://www.nih.gov/newsevents/news-releases/nih-clinical-trial-investigationalvaccine-covid-19-begin


id: cord-317583-jhulvfev
sid: 301
tid: 1
pos: NOUN
token:
  https://www.information.dk/udland/2019/12/new-data-reveals-serious-problems-with-the-eus-officialpublic-opinion-polls

lemma:
  https://www.information.dk/udland/2019/12/new-data-reveals-serious-problems-with-the-eus-officialpublic-opinion-poll


