# bib

id: cord-015384-bz7ui5a0
author: Hans-Peter, Kapfhammer
date: 2008-11-27
extension: .txt
mime: text/plain
words: 2531
sentence: 114
flesch: 24
cache: cache/cord-015384-bz7ui5a0.txt
txt: txt/cord-015384-bz7ui5a0.txt
title:
  Posttraumatic stress disorder in survivors of acute respiratory distress syndrome (ARDS) and septic shock

summary:
  Zum Zeitpunkt der Entlassung von der Intensivstation hatten 43,5% dieser Patienten das Vollbild einer PTSD, 8,9% wiesen eine sub-PTSD auf. Als Risikofaktoren für die Entwicklung eines PTSD konnten nicht die Schwere der somatischen Erkrankung (APA-CHE II Score, Lung Injury Score), aber die Anzahl der Tage der intensivmedizinischen


id: cord-001020-2iwsx727
author: Gupta, Kushagra
title: Adipose-derived stem cells weigh in as novel therapeutics for acute lung injury
date: 2013-02-28
extension: .txt
mime: text/plain
words: 1359
sentence: 47
flesch: 42
cache: cache/cord-001020-2iwsx727.txt
txt: txt/cord-001020-2iwsx727.txt
summary:
  Adipose tissue is abundant, expendable, easily accessible, and can be a waste product of many therapeutic and cosmetic procedures The Acute Respiratory Distress Syndrome Network: Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome Immunomodulatory activity of mesenchymal stem cells Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues Hepatitis B virus infection and replication in human bone marrow mesenchymal stem cells Current status of human adiposederived stem cells: diff erentiation into hepatocyte-like cells IFATS collection: in vivo therapeutic potential of human adipose tissue mesenchymal stem cells after transplantation into mice with liver injury Autologous transplantation of adipose-derived mesenchymal stem cells markedly reduced acute ischemia-reperfusion lung injury in a rodent model Melatonin treatment improves adipose-derived mesenchymal stem cell therapy for acute lung ischemiareperfusion injury Comparison of the therapeutic eff ects of human and mouse adipose-derived stem cells in a murine model of lipopolysaccharide-induced acute lung injury Adipose tissue-derived stem cells promote prostate tumor growth This work was supported by PHS grants #HL086814 and HL111835, and PO1HL105339, and The Brigham and Women's Hospital-Lovelace Respiratory Research Institute Consortium. There is an urgent need for effective therapies for acute lung injury.


id: cord-005832-p1joajvn
author: Liu, Zhicheng
title: Protective effect of gossypol on lipopolysaccharide-induced acute lung injury in mice
date: 2013-02-23
extension: .txt
mime: text/plain
words: 3098
sentence: 139
flesch: 47
cache: cache/cord-005832-p1joajvn.txt
txt: txt/cord-005832-p1joajvn.txt
summary:
  Blank control and LPS group mice were given an equal volume of distilled water by i.p. 1 h later, mice were slightly anesthetized with an inhalation of diethyl ether, 10 lg of LPS in 50 ll PBS was instilled intranasal (i.n.) to induce lung injury. The purpose of this study was to evaluate the effect of gossypol on acute lung injury (ALI) induced by lipopolysaccharide (LPS) in mice.


id: cord-331887-kagggou1
author: liu, Chang
date: 2020-09-09
extension: .txt
mime: text/plain
words: 3202
sentence: 116
flesch: 46
cache: cache/cord-331887-kagggou1.txt
txt: txt/cord-331887-kagggou1.txt
title:
  An integrated network pharmacology and RNA-Seq approach for exploring the preventive effect of Lonicerae japonicae flos on LPS-induced acute lung injury

summary:
  AIM OF THE STUDY: In this study, we examined the main active ingredients in LJF and the protective effects of LJF on LPS-induced ALI in rats. First, the main active ingredients of LJF were screened in the TCMSP database, and the ALI-associated targets were collected from the GeneCards database.


id: cord-102958-q8jamg07
author: Hahka, Taija M.
date: 2020-09-14
extension: .txt
mime: text/plain
words: 3752
sentence: 153
flesch: 38
cache: cache/cord-102958-q8jamg07.txt
txt: txt/cord-102958-q8jamg07.txt
title:
  Resiniferatoxin (RTX) ameliorates acute respiratory distress syndrome (ARDS) in a rodent model of lung injury

summary:
  Combined with the results shown in the current model of ALI, the potential of RTX to rescue lung function and protect multiple organs from collateral damage due to lung injury triggered inflammation is very encouraging and warrants additional studies as a rescue therapy for patients with lung injuries or infections resulting in inflammatory -mediated pneumonia. Therefore, in the current study we hypothesized that ablation of lung afferent innervation (thoracic spinal) by application of an ultrapotent, selective afferent neurotoxin, resiniferatoxin (RTX) will modify the course of the pathology including lung edema and local pulmonary inflammation associated with progressive ALI. Committee of the University of Nebraska Medical Center and performed in accordance with the National Institutes of Health's Guide for Use and Care of Laboratory Animals and with ARRIVE guidelines.


id: cord-000812-mu5u5bvj
author: Wiesen, Jonathan
date: 2012-08-28
extension: .txt
mime: text/plain
words: 4101
sentence: 154
flesch: 40
cache: cache/cord-000812-mu5u5bvj.txt
txt: txt/cord-000812-mu5u5bvj.txt
title:
  Relative cost and outcomes in the intensive care unit of acute lung injury (ALI) due to pandemic influenza compared with other etiologies: a single-center study

summary:
  World now at the start of 2009 influenza pandemic California Pandemic (H1N1) Working Group: Severe 2009 H1N1 influenza in pregnant and postpartum women in California Pediatric hospitalizations associated with 2009 pandemic influenza A (H1N1) in Argentina Critical care services and H1N1 influenza in Australia and New Zealand Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome Critically Ill patients with 2009 influenza A(H1N1) in Mexico Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain Critically ill patients with 2009 influenza A(H1N1) infection in Canada Pandemic (H1N1) 2009: epidemiological, clinical and prevention aspects Hospitalized patients with 2009 H1N1 influenza in the United States Pandemic (H1N1) 2009 influenza Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic (H1N1) 2009 Influenza, Bautista E, Chotpitayasunondh T: Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection Clinical management of pandemic 2009 influenza A(H1N1) infection H1N1: viral pneumonia as a cause of acute respiratory distress syndrome Ventilator management for hypoxemic respiratory failure attributable to H1N1 novel swine origin influenza virus Hospitalized patients with 2009 H1N1 influenza infection: the Mayo Clinic experience Clinical findings and demographic factors associated with ICU admission in Utah due to novel 2009 influenza A(H1N1) infection The macroeconomic impact of pandemic influenza: estimates from models of the United Kingdom, France, Belgium and The Netherlands Cost-effectiveness analysis of hospital infection control response to an epidemic respiratory virus threat Economic consequences to society of pandemic H1N1 influenza 2009 -preliminary results for Sweden Effectiveness and cost-effectiveness of vaccination against pandemic influenza (H1N1) 2009 Research electronic data capture (REDCap)-a metadata-driven methodology and workflow process for providing translational research informatics support Severe refractory hypoxaemia in H1N1 (2009) intensive care patients: initial experience in an Asian regional hospital Lung recruitment in patients with the acute respiratory distress syndrome Epidemiology and outcomes of acute lung injury Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome Adult respiratory distress syndrome: hospital charges and outcome according to underlying disease Variable costs of ICU patients: a multicenter prospective study Relative cost and outcomes in the intensive care unit of acute lung injury (ALI) due to pandemic influenza compared with other etiologies: a single-center study The authors declare that they have no competing interests. Compared with other studies of pandemic influenza patients who required mechanical ventilation, SOFA scores (mean 8.3) were similar, although APACHE II (25 ± 9) scores were higher [5] [6] [7] [8] 14, 16, 17, 23] .


id: cord-007858-1ijxilpb
author: Xu, G.L.
date: 2005-04-08
extension: .txt
mime: text/plain
words: 4057
sentence: 165
flesch: 48
cache: cache/cord-007858-1ijxilpb.txt
txt: txt/cord-007858-1ijxilpb.txt
title:
  Attenuation of acute lung injury in mice by oxymatrine is associated with inhibition of phosphorylated p38 mitogen-activated protein kinase

summary:
  In the present study, our data revealed that serum TNF-␣ level was higher in oleic acid group than that in control group. Representative photomicrographs showing: epithelial cell swelling (endoplasmic reticulum dilation and mitochondria swelling) (B), the existence of red blood cells (C) and inflammatory cells (D) in alveolar spaces were observed in oleic acid group.


id: cord-017107-sg8n12hs
author: Suri, H. S.
title: Epidemiology of Acute Respiratory Failure and Mechanical Ventilation
date: 2008
extension: .txt
mime: text/plain
words: 4117
sentence: 196
flesch: 38
cache: cache/cord-017107-sg8n12hs.txt
txt: txt/cord-017107-sg8n12hs.txt
summary:
  The burden of acute respiratory failure is high in terms of mortality and morbidity as well as the cost of its principal treatment, mechanical ventilation. Very few epidemiologic studies have evaluated the prevalence and outcome of acute respiratory failure and mechanical ventilation in general.


id: cord-320681-b3ui95vx
author: Zhang, Rui
title: COVID-19: Melatonin as a potential adjuvant treatment
date: 2020-06-01
extension: .txt
mime: text/plain
words: 4147
sentence: 157
flesch: 32
cache: cache/cord-320681-b3ui95vx.txt
txt: txt/cord-320681-b3ui95vx.txt
summary:
  Melatonin exerts anti-inflammatory effects through various pathways. TNF-α, IL-1β, IL-6, and IL-8, and an elevation in the level of anti-inflammatory cytokine IL-10


id: cord-006605-tsk3pakb
author: Jesmin, Subrina
date: 2006-11-30
extension: .txt
mime: text/plain
words: 4514
sentence: 190
flesch: 40
cache: cache/cord-006605-tsk3pakb.txt
txt: txt/cord-006605-tsk3pakb.txt
title:
  Differential Expression, Time Course and Distribution of Four PARs in Rats with Endotoxin-induced Acute Lung Injury

summary:
  key: cord-006605-tsk3pakb authors: Jesmin, Subrina; Gando, Satoshi; Zaedi, Sohel; Sakuraya, Fumika title: Differential Expression, Time Course and Distribution of Four PARs in Rats with Endotoxin-induced Acute Lung Injury date: 2006-11-30 journal: Inflammation DOI: 10.1007/s10753-006-9017-8 sha: doc_id: 6605 cord_uid: tsk3pakb The hypothesis that the expression of protease-activated receptors (PARs) protein is regulated at the level of transcription and that PAR isoforms, PAR-1, PAR-2, PAR-3, and PAR-4, in lung tissue show different patterns of expression in lipopolysaccharide (LPS)-induced acute lung injury (ALI) was tested. We examined the expression of protein and mRNA and the immunohistochemical localization of PAR isoforms in lung tissues 1, 3, 6, and 10 h after LPS administration.


id: cord-001473-aki28lhp
author: Chen, Qi Xing
title: Silencing airway epithelial cell-derived hepcidin exacerbates sepsis-induced acute lung injury
date: 2014-08-06
extension: .txt
mime: text/plain
words: 4521
sentence: 210
flesch: 40
cache: cache/cord-001473-aki28lhp.txt
txt: txt/cord-001473-aki28lhp.txt
summary:
  These results demonstrated that in the current study the intratracheal administration of Ad-shHepc1 only silenced the hepcidin gene transcription in AECs, which was in accordance with previous studies that adenovirus-mediated intratracheal gene delivery specifically inhibited targeted gene expression in lung epithelial cells but not in alveolar macrophages and other organs [29, 30] . A systematic review Mortality rates for patients with acute lung injury/ARDS have decreased over time Human defensins and LL-37 in mucosal immunity Hiemstra PS: Defensins and cathelicidins in inflammatory lung disease: beyond antimicrobial activity Expression and activity of beta-defensins and LL-37 in the developing human lung Increased levels of antimicrobial peptides in tracheal aspirates of newborn infants during infection High concentrations of alpha-defensins in plasma and bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome Protection against Pseudomonas aeruginosa pneumonia and sepsis-induced lung injury by overexpression of beta-defensin-2 in rats Hepcidin and iron regulation, 10 years later Fine tuning of hepcidin expression by positive and negative regulators Hepcidin in human iron disorders: therapeutic implications Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice Hepcidin and the iron-infection axis Iron in innate immunity: starve the invaders Two to tango: regulation of mammalian iron metabolism Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice Hepcidin protects against lipopolysaccharide-induced liver injury in a mouse model of obstructive jaundice Hepcidin expression in human airway epithelial cells is regulated by interferon-γ Functional differences between hepcidin 1 and 2 in transgenic mice Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia Triggering receptor expressed on myeloid cells-2 protects against polymicrobial sepsis by enhancing bacterial clearance Hussell T: A critical function for CD200 in lung immune homeostasis and the severity of influenza infection Hepatic iron concentration does not predict response to standard and pegylated-IFN/ribavirin therapy in patients with chronic hepatitis C Attenuation of IgG immune complex-induced acute lung injury by silencing C5aR in lung epithelial cells In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-kappaB Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination


id: cord-006573-mwtqxwbw
author: Zhang, Leifang
date: 2018-06-16
extension: .txt
mime: text/plain
words: 4706
sentence: 225
flesch: 43
cache: cache/cord-006573-mwtqxwbw.txt
txt: txt/cord-006573-mwtqxwbw.txt
title:
  SOCS-1 Suppresses Inflammation Through Inhibition of NALP3 Inflammasome Formation in Smoke Inhalation-Induced Acute Lung Injury

summary:
  Briefly, after isolation of mouse lung macrophages, cells were cultured in six well plates overnight. Mice lungs and survival were examined after smoke exposure.


id: cord-258087-93yfs7ve
author: Flores, Carlos
date: 2008-10-25
extension: .txt
mime: text/plain
words: 4740
sentence: 156
flesch: 28
cache: cache/cord-258087-93yfs7ve.txt
txt: txt/cord-258087-93yfs7ve.txt
title:
  A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury

summary:
  Positive genetic association studies with acute lung injury/acute respiratory distress syndrome susceptibility and/or outcome (by year of publication) Percentage of studies scored as adequate for 14 criteria (x-axis) used for the quality assessment of genetic association studies supporting susceptibility and/or outcome in acute lung injury Percentage of studies scored as adequate for 14 criteria (x-axis) used for the quality assessment of genetic association studies supporting susceptibility and/or outcome in acute lung injury. key: cord-258087-93yfs7ve authors: Flores, Carlos; del Mar Pino-Yanes, Maria; Villar, Jesús title: A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury date: 2008-10-25 journal: Crit Care DOI: 10.1186/cc7098 sha: doc_id: 258087 cord_uid: 93yfs7ve INTRODUCTION:


id: cord-006507-amo8e81h
author: Yang, Zhongwei
title: TLR4 as receptor for HMGB1-mediated acute lung injury after liver ischemia/reperfusion injury
date: 2013-04-29
extension: .txt
mime: text/plain
words: 5618
sentence: 223
flesch: 45
cache: cache/cord-006507-amo8e81h.txt
txt: txt/cord-006507-amo8e81h.txt
summary:
  Lung tissue from the I/R group displayed a feature of lung injury, including alveolar septal thickening, interstitial edema, and vascular congestion, as well as a mild neutrophil infiltration in the interstitium. P/F ratio, one of the markers for lung injury, was determined at baseline and 18 h after operation (Figure 2c ; n ¼ 6 in each group).


id: cord-005980-e2s0racp
author: Wu, Xiaojing
title: TIPE2 ameliorates lipopolysaccharide-induced apoptosis and inflammation in acute lung injury
date: 2019-09-05
extension: .txt
mime: text/plain
words: 5217
sentence: 240
flesch: 44
cache: cache/cord-005980-e2s0racp.txt
txt: txt/cord-005980-e2s0racp.txt
summary:
  0.05 versus LPS group lung inflammation and apoptosis, which may be associated with decreased NF-κB and JNK activity. We investigated the effects of TIPE2 overexpression on lung cell apoptosis in LPS-challenged mice by TUNEL staining.


id: cord-002329-7s0ytfed
author: Zeng, Ling
date: 2016-12-07
extension: .txt
mime: text/plain
words: 5379
sentence: 245
flesch: 51
cache: cache/cord-002329-7s0ytfed.txt
txt: txt/cord-002329-7s0ytfed.txt
title:
  The cellular kinetics of lung alveolar epithelial cells and its relationship with lung tissue repair after acute lung injury

summary:
  Rats were sacrificed on days 1, 2, 3, 5 and 7 after injury to study time-specific proliferation of lung epithelial cells (n = 10 for each group). Rat after ALI or sham surgery were sacrified on days 1, 2, 3, 5 and 7 after ALI to study time-specific proliferation of lung epithelial cells.


id: cord-291076-p350i54m
author: Wang, Renxi
title: The role of C5a in acute lung injury induced by highly pathogenic viral infections
date: 2015-05-06
extension: .txt
mime: text/plain
words: 5804
sentence: 252
flesch: 34
cache: cache/cord-291076-p350i54m.txt
txt: txt/cord-291076-p350i54m.txt
summary:
  The complement-activated product C5a is a strong chemoattractant and is involved in the recruitment of inflammatory cells such as neutrophils, eosinophils, monocytes, and T lymphocytes, in activation of phagocytic cells and release of granulebased enzymes and generation of oxidants. In lung fibroses, inflammatory cells produce a significantly greater amount of ROS.


id: cord-103496-8tq78p2z
author: Wang, Ting
date: 2020-11-13
extension: .txt
mime: text/plain
words: 5865
sentence: 238
flesch: 40
cache: cache/cord-103496-8tq78p2z.txt
txt: txt/cord-103496-8tq78p2z.txt
title:
  RAC1 nitration at Y32 IS involved in the endothelial barrier disruption associated with lipopolysaccharide-mediated acute lung injury

summary:
  Using a murine model of ALI induced by intratracheal installation of LPS we found that NipR2 successfully prevented Rac1 nitration and Rac1 inhibition, and more importantly attenuated pulmonary inflammation, reduced lung injury and prevented the loss of lung function. As NipR2 also reduces sepsis induced ALI in the mouse lung, we conclude that Rac1 nitration is a therapeutic target in ALI.


id: cord-000492-ec5qzurk
author: Devaney, James
title: Clinical Review: Gene-based therapies for ALI/ARDS: where are we now?
date: 2011-06-20
extension: .txt
mime: text/plain
words: 6021
sentence: 250
flesch: 34
cache: cache/cord-000492-ec5qzurk.txt
txt: txt/cord-000492-ec5qzurk.txt
summary:
  Antibodies that bind antigens selectively expressed on the pulmonary endothelial surface can be complexed to gene vectors to facilitate selective targeting following intravenous administration + ,K + -ATPase rescues endotoxin-induced lung injury Interleukin-10 gene transfer: prevention of multiple organ injury in a murine cecal ligation and puncture model of sepsis Nonviral gene delivery with indoleamine 2,3-dioxygenase targeting pulmonary endothelium protects against ischemia-reperfusion injury Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, infl ammation, and neutrophil infl ux after hemorrhagic shock and sepsis Caveolin-1 siRNA increases the pulmonary microvascular and alveolar epithelial permeability in rats Interleukin-10 delivery via mesenchymal stem cells: a novel gene therapy approach to prevent lung ischemia-reperfusion injury Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fi brosis Cell-based gene transfer of vascular endothelial growth factor attenuates monocrotaline-induced pulmonary hypertension Microvascular regeneration in established pulmonary hypertension by angiogenic gene transfer Tetracycline-inducible transgene expression mediated by a single AAV vector Effi cient transfection of non-proliferating human airway epithelial cells with a synthetic vector system Tailoring the AAV vector capsid for gene therapy Artifi cial evolution with adeno-associated viral libraries Analysis and optimization of the cationic lipid component of a lipid/ peptide vector formulation for enhanced transfection in vitro and in vivo Stabilized integrin-targeting ternary LPD (lipopolyplex) vectors for gene delivery designed to disassemble within the target cell CpG-free plasmids confer reduced infl ammation and sustained pulmonary gene expression Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12 Targeting type II and Clara cells for adenovirus-mediated gene transfer using the surfactant protein B promoter Development of lentiviral vectors with regulated respiratory epithelial expression in vivo Expression of CFTR from a ciliated cell-specifi c promoter is ineff ective at correcting nasal potential diff erence in CF mice A human epithelium-specifi c vector optimized in rat pneumocytes for lung gene therapy Tight control of gene expression in mammalian cells by tetracycline-responsive promoters Use of a new generation reverse tetracycline transactivator system for quantitative control of conditional gene expression in the murine lung Construction of an rtTA2(s)-m2/ tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and non-human primates Adenoviral vector transfection into the pulmonary epithelium after cecal ligation and puncture in rats Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins aff ects the transduction effi ciency of recombinant vectors GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium Spatial and temporal expression of surfactant proteins in hyperoxia-induced neonatal rat lung injury Intrapulmonary TNF gene therapy reverses sepsis-induced suppression of lung antibacterial host defense Clinical Review: Gene-based therapies for ALI/ARDS: where are we now?


id: cord-005812-hx6lkuj0
author: Morty, Rory E.
date: 2007-05-25
extension: .txt
mime: text/plain
words: 6238
sentence: 244
flesch: 32
cache: cache/cord-005812-hx6lkuj0.txt
txt: txt/cord-005812-hx6lkuj0.txt
title:
  Alveolar fluid clearance in acute lung injury: what have we learned from animal models and clinical studies?

summary:
  The acute respiratory distress syndrome Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome Lung epithelial fluid transport and the resolution of pulmonary edema Alveolar edema must be cleared for the acute respiratory distress syndrome patient to survive Function of the alveolar epithelial barrier under pathologic conditions Sodium channels in alveolar epithelial cells: molecular characterization, biophysical properties, and physiological significance Invited review: lung edema clearance: role of Na (+)-K (+)-ATPase Novel role for CFTR in fluid absorption from the distal airspaces of the lung RNA interference for alpha-ENaC inhibits rat lung fluid absorption in vivo Alterations of the gas exchange apparatus in adult respiratory insufficiency associated with septicemia Mechanisms of alveolar epithelial repair in acute lung injury-a translational approach Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema Alveolar epithelium: role in lung fluid balance and acute lung injury Alveolar epithelial barrier functions in ventilated perfused rabbit lungs Oleic acid inhibits alveolar fluid reabsorption: a role in acute respiratory distress syndrome? The AFC block was attributed to impaired sodium transport resulting from decreased membrane abundance of the Na,K-ATPase in rat lungs


id: cord-023890-z346hh2c
author: Cotogni, Paolo
title: Polyunsaturated Fatty Acids and Cytokines: Their Relationship in Acute Lung Injury
date: 2015
extension: .txt
mime: text/plain
words: 6965
sentence: 233
flesch: 33
cache: cache/cord-023890-z346hh2c.txt
txt: txt/cord-023890-z346hh2c.txt
summary:
  Persistently high levels of pro-inflammatory cytokines, as well as a reduced production of anti-inflammatory cytokines, have been demonstrated to be correlated with the severity of lung injury. (e) A decreased production of pro-inflammatory cytokines, due to decreased activation of pro-inflammatory transcription factors such as nuclear factor κ-B and increased activation of anti-inflammatory transcription factors such as peroxisome proliferator-activated receptor-γ.


id: cord-001945-ueccexxc
author: Yang, Ce
date: 2016-02-11
extension: .txt
mime: text/plain
words: 6710
sentence: 253
flesch: 30
cache: cache/cord-001945-ueccexxc.txt
txt: txt/cord-001945-ueccexxc.txt
title:
  Stem/progenitor cells in endogenous repairing responses: new toolbox for the treatment of acute lung injury

summary:
  Recently, the discovery of human lung stem cells and their relevant studies has opened the door of hope again, which might put us on the path to repair our injured body parts, lungs on demand. Presently, as compared with the boosting of murine lung stem cells, the investigation of human lung stem cells (HLSCs) remains superficial since their presentation by Kajstura et al in 2011 [81] .


id: cord-305173-95o5z685
author: Martin, Thomas R.
title: A TRIFfic Perspective on Acute Lung Injury
date: 2008-04-18
extension: .txt
mime: text/plain
words: 1843
sentence: 63
flesch: 34
cache: cache/cord-305173-95o5z685.txt
txt: txt/cord-305173-95o5z685.txt
summary:
  Activation of innate immune pathways combined with the physical stresses created by mechanical ventilation cause a synergistic increase in lung injury, but the mechanisms underlying ALI are not clear (Dos Santos and Slutsky, 2006) . In order to identify susceptibility factors for lung injury, Imai and colleagues screened several strains of mice using a A TRIffic Perspective on Acute Lung Injury Thomas R. Martin 1, * and Mark M. Wurfel 1 simple model of lung injury, intratracheal instillation of 1.5 N hydrochloric acid (HCl), which approximates severe gastric acid aspiration.


id: cord-282336-zvc04s39
author: Choudhary, Ishita
date: 2020-09-02
extension: .txt
mime: text/plain
words: 7920
sentence: 288
flesch: 40
cache: cache/cord-282336-zvc04s39.txt
txt: txt/cord-282336-zvc04s39.txt
title:
  Tristetraprolin Overexpression in Non-hematopoietic Cells Protects Against Acute Lung Injury in Mice

summary:
  These phenotypes were shown to be essentially completely prevented in TTP KO mice with either TNF receptor deficiency, or when TTP KO mice were treated with anti-TNF antibodies (5) . These increases were associated with an increased injury to the pulmonary vascular barrier, as depicted by the presence of red blood cells in the cytospins prepared from the BALF fluid of TTP KO mice ( Figure 1E ; right panel, black arrow) versus control LPS-challenged WT mice ( Figure 1E ; left panel).


id: cord-308892-5gbjdr0u
author: Fu, Lin
date: 2020-04-06
extension: .txt
mime: text/plain
words: 2673
sentence: 143
flesch: 51
cache: cache/cord-308892-5gbjdr0u.txt
txt: txt/cord-308892-5gbjdr0u.txt
title:
  Acute liver injury and its association with death risk of patients with COVID-19: a hospital-based prospective case-cohort study

summary:
  By multivariate logistic regression, male, older age and lymphocyte reduction were three important independent risk factors predicting ALI among COVID-19 patients. Conclusions: ALI at early stage elevates death risk of COVID-19 patients.


id: cord-012045-1cqqj84n
author: Li, Tiao
title: The Role of Deubiquitinating Enzymes in Acute Lung Injury and Acute Respiratory Distress Syndrome
date: 2020-07-08
extension: .txt
mime: text/plain
words: 7511
sentence: 356
flesch: 30
cache: cache/cord-012045-1cqqj84n.txt
txt: txt/cord-012045-1cqqj84n.txt
summary:
  Protein ubiquitination is reversible, the covalently attached monoubiquitin or polyubiquitin moieties within the targeted protein can be removed by a group of enzymes called deubiquitinating enzymes (DUBs). Signal transductions in control of protein stability and availability, including protein ubiquitination and degradation, are typical among the pathways.


id: cord-319936-5uze06rp
author: Dixon, Barry
title: A phase 1 trial of nebulised heparin in acute lung injury
date: 2008-05-06
extension: .txt
mime: text/plain
words: 3139
sentence: 156
flesch: 48
cache: cache/cord-319936-5uze06rp.txt
txt: txt/cord-319936-5uze06rp.txt
summary:
  key: cord-319936-5uze06rp authors: Dixon, Barry; Santamaria, John D; Campbell, Duncan J title: A phase 1 trial of nebulised heparin in acute lung injury date: 2008-05-06 journal: Crit Care DOI: 10.1186/cc6894 sha: doc_id: 319936 cord_uid: 5uze06rp INTRODUCTION: Animal studies of acute lung injury (ALI) suggest nebulised heparin may limit damage from fibrin deposition in the alveolar space and microcirculation.


id: cord-006778-qnxyhmw5
author: Chen, Xuxin
date: 2017-08-12
extension: .txt
mime: text/plain
words: 8546
sentence: 408
flesch: 50
cache: cache/cord-006778-qnxyhmw5.txt
txt: txt/cord-006778-qnxyhmw5.txt
title:
  Downregulation of Paralemmin-3 Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Rats by Regulating Inflammatory Response and Inhibiting Formation of TLR4/MyD88 and TLR4/TRIF Complexes

summary:
  However, the downregulation of PALM3 did impact the upregulation of TLR4, MyD88, and TRIF protein expression induced by LPS in rat lung tissues. In the present study, we found that the downregulation of PALM3 suppressed NF-κB-DNA-binding activity and decreased NF-κB phospho-p65 and phospho-IRF3 protein levels in the nucleus of ALI rat lung tissues.


id: cord-017853-mgsuwft0
author: Machado, Roberto F.
title: Genomics of Acute Lung Injury and Vascular Barrier Dysfunction
date: 2010-06-28
extension: .txt
mime: text/plain
words: 9206
sentence: 311
flesch: 26
cache: cache/cord-017853-mgsuwft0.txt
txt: txt/cord-017853-mgsuwft0.txt
summary:
  This approach identified multiple genes already recognized as ALI genes (such as IL-6, AQP-1, and PAI-1), but also identified several novel genes that were not previously known to be mechanistically involved in ALI [38] . Together, these approaches identified novel ALI genes such as PBEF, chemokine receptor (CXCR-4) GADD45.


id: cord-000137-idffrnac
author: Xiang, Meng
title: Pattern Recognition Receptor–Dependent Mechanisms of Acute Lung Injury
date: 2009-11-02
extension: .txt
mime: text/plain
words: 9140
sentence: 287
flesch: 28
cache: cache/cord-000137-idffrnac.txt
txt: txt/cord-000137-idffrnac.txt
summary:
  The PI3K/Akt pathway was also reported to be involved in TLR4-induced expression of IL-1β, TNF-α and chemokine macro phage inflammatory protein (MIP)-2 (78) . What we have learned from small interfering RNAs Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants Toll-like receptors in normal and cystic fibrosis airway epithelial cells Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium Hsp72 induces inflammation and regulates cytokine production in airway epithelium through a TLR4-and NF-kappaB-dependent mechanism Extracellular Hsp72, an endogenous DAMP, is released by virally infected airway epithelial cells and activates neutrophils via Toll-like receptor (TLR)-4 DNA microarray analysis of gene expression in alveolar epithelial cells in response to TNFalpha, LPS, and cyclic stretch Diffusible signal to murine alveolar macrophages from lipopolysaccharideand Escherichia coli-stimulated lung Type II epithelial cells Enhancement of TLR-mediated innate immune responses by peptidoglycans through NOD signaling Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo TLR signaling in the gut in health and disease Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis Systemic inflammation and remote organ injury following trauma require HMGB1 Toll-like receptors as targets in chronic liver diseases Evolving concepts in the pathogenesis of postinjury multiple organ failure Hemorrhagic shock primes for increased expression of cytokine-induced neutrophil chemoattractant in the lung: role in pulmonary inflammation following lipopolysaccharide Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation Neutrophil NAD(P)H oxidase is required for hemorrhagic shock-enhanced TLR2 up-regulation in alveolar macrophages in response to LPS NF-kappa B and STAT5 play important roles in the regulation of mouse Tolllike receptor 2 gene expression HMGB1 as a late mediator of lethal systemic inflammation Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62 Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2 HMGB-1 as a late mediator of endotoxin lethality in mice Reversing established sepsis with antagonists of endogenous highmobility group box 1 The danger model: a renewed sense of self Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses Addicted to death: invasive cancer and the immune response to unscheduled cell death HMGB1 contributes to the development of acute lung injury after hemorrhage Hepatic ischemia/ reperfusion injury involves functional TLR4 signaling in nonparenchymal cells Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock Regulation of lung injury and repair by Toll-like receptors and hyaluronan Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4 Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages.


id: cord-340865-sut3nf2a
author: Wang, Shuang
title: Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome
date: 2015-04-29
extension: .txt
mime: text/plain
words: 3594
sentence: 166
flesch: 45
cache: cache/cord-340865-sut3nf2a.txt
txt: txt/cord-340865-sut3nf2a.txt
summary:
  Incidence and outcomes of acute lung injury Spectrum of acute lung injury, ARDS, sepsis The control of adaptive immune responses by the innate immune system The inflammasome: an integrated view The machinery of Nod-like receptors: refining the paths to immunity and cell death Hemorrhagic shock augments Nlrp3 inflammasome activation in the lung through impaired pyrin induction The P2X7 receptor: a key player in IL-1 processing and release Lipopolysaccharide-induced lung injury: role of P2X7 receptor Electroporation-mediated gene transfer of the Na +, K+-ATPase rescues endotoxin-induced lung injury Lupus nephritis: glycogen synthase kinase 3beta promotes renal damage through activation of NLRP3 inflammasome in lupus-prone mice Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration Hemorrhagic shock primes for increased expression of cytokine-induced neutrophil chemoattractant in the lung: role in pulmonary inflammation following lipopolysaccharide P2X7 blockade attenuates murine lupus nephritis by inhibiting activation of the NLRP3/ASC/caspase 1 pathway Nucleotide receptors: an emerging family of regulatory molecules in blood cells Pharmacologic properties of P(2Z)/P2X(7)receptor characterized in murine dendritic cells: role on the induction of apoptosis Purinergic receptor distribution in endothelial cells in blood vessels: a basis for selection of coronary artery grafts ATP-induced pore formation in the plasma membrane of rat peritoneal mast cells P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical production Identification of two novel markers for alveolar epithelial type I and II cells ATP acts as an agonist to promote stimulus-induced secretion of IL-1 beta and IL-18 in human blood Liaisons dangereuses: P2X(7) and the inflammasome Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages NLRP3 inflammasome activation is essential for paraquat-induced acute lung injury Critical role for the NLRP3 inflammasome during acute lung injury Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome Functional relevance of NLRP3 inflammasome-mediated interleukin (IL)-1beta during acute allergic airway inflammation Involvement of NLRP3 inflammasome in rituximab-induced interstitial lung disease: a case report The role of the NLRP3 inflammasome in fibrosis Directing traffic: IL-17 and IL-22 coordinate pulmonary immune defense The biological functions of T helper 17 cell effector cytokines in inflammation Th17 cell differentiation: the long and winding road IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis IL-17 response mediates acute lung injury induced by the 2009 pandemic influenza A (H1N1) virus Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome An interferon-gammarelated cytokine storm in SARS patients A probable role for IFN-gamma in the development of a lung immunopathology in SARS Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation P2X7 receptor inhibition protects against ischemic acute kidney injury in mice Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-kappa B-dependent IL-6 expression in human monocytes This project was supported by grants from the Science and Technology All authors declare no conflicts of interest in this study. Moreover, blockage of P2X7 significantly inhibited NLRP3 inflammasome activation and IL-1β production in bone marrow derived macrophages.


id: cord-255440-ls1l2mlg
author: Tindle, Courtney
title: Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19
date: 2020-10-18
extension: .txt
mime: text/plain
words: 9984
sentence: 325
flesch: 41
cache: cache/cord-255440-ls1l2mlg.txt
txt: txt/cord-255440-ls1l2mlg.txt
summary:
  Organoids and monolayers used for lung cell type studies were lysed using RNA lysis buffer followed by RNA CoV2 studies were lysed in TRI-Reagent and RNA was extracted using Zymo Research Direct-zol RNA Miniprep. Organoid and monolayer cell-type gene expression was measured by qRT-PCR using 2x SYBR Green qPCR Master Mix. As for personalization, our model is derived from adult lung stem cells from deep lung biopsies; each organoid line was established from one patient.


id: cord-337973-djqzgc1k
author: Hao, Siyuan
title: Long Period Modeling SARS-CoV-2 Infection of in Vitro Cultured Polarized Human Airway Epithelium
date: 2020-08-28
extension: .txt
mime: text/plain
words: 2632
sentence: 78
flesch: 36
cache: cache/cord-337973-djqzgc1k.txt
txt: txt/cord-337973-djqzgc1k.txt
summary:
  Methods for establishing 575 primary cultures Well-differentiated 577 human airway epithelial cell cultures Culturing the unculturable: human coronavirus HKU1 580 infects, replicates, and produces progeny virions in human ciliated airway epithelial cell cultures Systematic 599 assembly of a full-length infectious clone of human coronavirus NL63 Avian Influenza virus glycoproteins restrict virus replication and 603 spread through human airway epithelium at temperatures of the proximal airways Human coronavirus 229E infects polarized airway epithelia from 607 the apical surface Infection and Propagation of Human Rhinovirus C in 610 Human Airway Epithelial Cells ACE2 receptor expression and severe acute respiratory 613 syndrome coronavirus infection depend on differentiation of human airway epithelia SARS-CoV replication and pathogenesis in 616 an in vitro model of the human conducting airway epithelium Characterization and Treatment of 620 SARS-CoV-2 in Nasal and Bronchial Human Airway Epithelia An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 626 in human airway epithelial cell cultures and multiple coronaviruses in mice Morphogenesis 630 and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Our observation that SARS-CoV-2 was unable to infect epithelial cells from the 299 basolateral side supports that the viral entry receptor ACE2 is polarly expressed at the apical 300 side 30, 31 .


id: cord-313091-ksrxsdpp
author: Shirato, Kazuya
title: Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry
date: 2017-12-06
extension: .txt
mime: text/plain
words: 4028
sentence: 147
flesch: 50
cache: cache/cord-313091-ksrxsdpp.txt
txt: txt/cord-313091-ksrxsdpp.txt
summary:
  We previously reported that clinical isolates of HCoV-229E preferred cell-surface TMPRSS2 to endosomal cathepsin for cell entry, and that they acquired the ability to use cathepsin L by repeated passage in cultured cells and were then able to enter cells via the endosomal pathway. Here, we show that clinical isolates of HCoV-OC43 and -HKU1 preferred the cell-surface TMRRSS2 to endosomal cathepsins for cell entry, similar to HCoV-229E. In addition, the cell-culture-adapted HCoV-OC43 lost the ability to infect and replicate in air-liquid interface cultures of human bronchial tracheal epithelial cells.


id: cord-023928-9a1w174h
author: Thomas, Neal J.
title: Genetic Predisposition to Critical Illness in the Pediatric Intensive Care Unit
date: 2011-12-16
extension: .txt
mime: text/plain
words: 12261
sentence: 416
flesch: 40
cache: cache/cord-023928-9a1w174h.txt
txt: txt/cord-023928-9a1w174h.txt
summary:
  It is unlikely as there are no reports of associations between surfactant protein gene polymorphisms and outcomes from pulmonary disease. As will be discussed below, genetic variations that infl uence the activity or level of the protein in several of these candidate genes have been examined in gene association studies in patients with ALI.


id: cord-010983-2bzllo0n
author: Adrover, Jose M.
title: Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation
date: 2020-01-13
extension: .txt
mime: text/plain
words: 11309
sentence: 448
flesch: 44
cache: cache/cord-010983-2bzllo0n.txt
txt: txt/cord-010983-2bzllo0n.txt
summary:
  Neutrophils from mouse and human blood were isolated as previously described (FACS sorting for mouse neutrophils, gradient isolation for human neutrophils), fixed in 4% PFA for 10 min and washed with PBS. However, because transcriptional changes take a relatively long time (in the range of hours) and diurnal transcriptional programs in mouse neutrophils favor their migration into tissues, we examined alternative mechanisms that might protect the tissues from the toxic activity of neutrophils.


id: cord-029488-l11ufs6k
author: Tomita, Kengo
date: 2020-07-21
extension: .txt
mime: text/plain
words: 5101
sentence: 174
flesch: 35
cache: cache/cord-029488-l11ufs6k.txt
txt: txt/cord-029488-l11ufs6k.txt
title:
  Vascular endothelial growth factor contributes to lung vascular hyperpermeability in sepsis-associated acute lung injury

summary:
  Taken together, our results indicate that VEGF can contribute to the development of non-cardiogenic lung edema in sepsis-associated ALI due to increased VEGF secretion from pulmonary vascular endothelial cells through multiple MAPK-dependent pathways. 5 Schematic diagram of the participation of VEGF released from pulmonary vascular endothelial cells in noncardiogenic high vascular permeability pulmonary edema associated with LPS-induced ALI.


id: cord-334528-xenq90xj
author: Chen, Hsing I
title: Acute lung injury and acute respiratory distress syndrome: experimental and clinical investigations
date: 2011-03-17
extension: .txt
mime: text/plain
words: 5315
sentence: 242
flesch: 29
cache: cache/cord-334528-xenq90xj.txt
txt: txt/cord-334528-xenq90xj.txt
summary:
  I. Light microscopy Ventilator-induced lung injury Cellular stress failure in ventilator-injured lungs Acute respiratory distress syndrome: a historical perspective The acute respiratory distress syndrome Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management Leukocyte elastase: physiological functions and role in acute lung injury Roles of neutrophil elastase and superoxide anion in leukotriene B4-induced lung injury in rabbit Chemokines in acute respiratory distress syndrome Transcriptional mechanisms of acute lung injury Alveolar epithelial fluid transport in acute lung injury: new insights Mechanisms of pulmonary edema clearance Perspective on lung injury and recruitment: a skeptical look at the opening and collapse story Critical care in AJRCCM Alveolar recruitment in acute lung injury Prone position augments recruitment and prevents alveolar overinflation in acute lung injury Hypercapnic acidosis attenuates endotoxin-induced acute lung injury Protective effects of hypercapnic acidosis on ventilator-induced lung injury Permissive hypercapnia: role in protective lung ventilatory strategies Hypercapnia via reduced rate and tidal volume contributes to lipopolysaccharide-induced lung injury Permissive hypercapnia impairs pulmonary gas exchange in the acute respiratory distress syndrome Nonventilatory treatments for acute lung injury and ARDS Ventilatory management of acute lung injury and acute respiratory distress syndrome Acute respiratory distress syndrome: pharmacological treatment options in development Pathophysiology and pharmacological treatment of pulmonary hypertension in acute respiratory distress syndrome Inhaled nitric oxide therapy in adults Exercise training attenuates septic responses in conscious rats Vascular endothelial growth factor and related molecules in acute lung injury Angiotensin-converting enzyme 2 protects from severe acute lung failure Insulin attenuates endotoxin-induced acute lung injury in conscious rats Comparison of propofol and midazolam for sedation in critically ill patients An update of its use in anaesthesia and conscious sedation The reduction of tumor necrosis factor-alpha release and tissue damage by pentobarbital in the experimental endotoxemia model N-acetylcysteine ameliorates lipopolysaccharide-induced organ damage in conscious rats Post-treatment with N-acetylcysteine ameliorates endotoxin shock-induced organ damage in conscious rats N-Acetylcysteine treatment to prevent the progression of multisystem organ failure: a prospective, randomized, placebo-controlled study Antioxidant supplementation in sepsis and systemic inflammatory response syndrome N-acetylcysteine as the magic bullet: too good to be true Experimental studies and clinical investigations were supported in part by grants from the National Science Council. [77, 78] Intratracheal instillation of hydrochloric acid (HCI) or gastric particles has been employed as experimental model of acute lung injury (ALI).


id: cord-317993-012hx4kc
author: Movia, Dania
date: 2020-07-24
extension: .txt
mime: text/plain
words: 6888
sentence: 274
flesch: 35
cache: cache/cord-317993-012hx4kc.txt
txt: txt/cord-317993-012hx4kc.txt
title:
  Preclinical Development of Orally Inhaled Drugs (OIDs)—Are Animal Models Predictive or Shall We Move Towards In Vitro Non-Animal Models?

summary:
  The so-called lung-on-chip is a microfluidic-based in vitro system in which lung epithelial cells are grown on one side of a membrane, and stromal cells on the other surface. Semin Heuze-Vourc'h, N. Innovative preclinical models for pulmonary drug delivery research Options for modeling the respiratory system: Inserts, scaffolds and microfluidic chips A biphasic chamber system for maintaining polarity of differentiation of cultured respiratory tract epithelial cells Adapting the Electrospinning Process to Provide Three Unique Environments for a Tri-layered In Vitro Model of the Airway Wall Use of porous membranes in tissue barrier and co-culture models A novel electrospun biphasic scaffold provides optimal three-dimensional topography for in vitro co-culture of airway epithelial and fibroblast cells Intermittent exposure to whole cigarette smoke alters the differentiation of primary small airway epithelial cells in the air-liquid interface culture ALI multilayered co-cultures mimic biochemical mechanisms of the cancer cell-fibroblast cross-talk involved in NSCLC MultiDrug Resistance Multilayered Cultures of NSCLC cells grown at the Air-Liquid Interface allow the efficacy testing of inhaled anti-cancer drugs Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke Altered generation of ciliated cells in chronic obstructive pulmonary disease Primary epithelial cell models for cystic fibrosis research Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus Regeneration of the lung: Lung stem cells and the development of lung mimicking devices In vitro generation of human pluripotent stem cell derived lung organoids A three-dimensional model of human lung development and disease from pluripotent stem cells Modelling Cryptosporidium infection in human small intestinal and lung organoids Use of three-dimensional organoids and lung-on-a-chip methods to study lung development, regeneration and disease Organoids as a Powerful Model for Respiratory Diseases Lung-On-A-Chip Technologies for Disease Modeling and Drug Development Reconstituting organ-level lung functions on a chip A human breathing lung-on-a-chip A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice A lung/liver-on-a-chip platform for acute and chronic toxicity studies A 3D human lung-on-a-chip model for nanotoxicity testing Multiorgan microfluidic platform with breathable lung chamber for inhalation or intravenous drug screening and development Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: A biopharmaceutical perspective Impaired Wound Healing of Alveolar Lung Epithelial Cells in a Breathing Lung-On-A-Chip Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID19 therapeutics in viral pandemics Biomimetic human lung-on-a-chip for modeling disease investigation Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung Modeling the lung:


id: cord-354829-god79qzw
author: Mao, Kaimin
date: 2020-09-23
extension: .txt
mime: text/plain
words: 6341
sentence: 242
flesch: 39
cache: cache/cord-354829-god79qzw.txt
txt: txt/cord-354829-god79qzw.txt
title:
  Identification of robust genetic signatures associated with lipopolysaccharide-induced acute lung injury onset and astaxanthin therapeutic effects by integrative analysis of RNA sequencing data and GEO datasets

summary:
  Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apoptosis dependent on Drp1-mediated mitochondrial fission Astaxanthin alleviated acute lung injury by inhibiting oxidative/nitrative stress and the inflammatory response in mice Astaxanthin prevents against lipopolysaccharideinduced acute lung injury and sepsis via inhibiting activation of MAPK/NF-κB NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and metaanalysis clusterProfiler: an R package for comparing biological themes among gene clusters Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential Evidence for chemokine synergy during neutrophil migration in ARDS Fernández-Botrán R. Modulation of acute inflammation by targeting glycosaminoglycan-cytokine interactions Contribution of neutrophils to acute lung injury Antiinflammatory activity of a novel family of aryl ureas compounds in an endotoxin-induced airway epithelial cell injury model C-X-C motif chemokine 13 (CXCL13) is a prognostic biomarker of idiopathic pulmonary fibrosis ZBP1: innate sensor regulating cell death and inflammation Dynamic gene expression analysis in a H1N1 influenza virus mouse pneumonia model The CC chemokine ligand 2 (CCL2) mediates fibroblast survival through IL-6 Complement inhibition decreases early fibrogenic events in the lung of septic baboons The cytokine-serum amyloid achemokine network Serum amyloid A is a biomarker of severe coronavirus disease and poor prognosis Serum amyloid A3 is a high density lipoprotein-associated acute-phase protein Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3 Long non-coding RNA MALAT1 regulates hyperglycaemia induced inflammatory process in the endothelial cells IL-6 induced lncRNA MALAT1 enhances TNF-α expression in LPS-induced septic cardiomyocytes via activation of SAA3 Emerging functions of serum amyloid a in inflammation Suppression of lipopolysaccharide-induced inflammatory response by fragments from serum amyloid a Serum amyloid a promotes LPS clearance and suppresses LPS-induced inflammation and tissue injury Knockdown of miR-660 protects nucleus pulposus cells from TNF-a-induced apoptosis by targeting serum amyloid A1 IRF7: activation, regulation, modification and function Attenuation of interferon regulatory factor 7 activity in local infectious sites of trachea and lung for preventing the development of acute lung injury caused by influenza a virus Mir-302c mediates influenza a virus-induced IFNβ expression by targeting NF-κB inducing kinase Then, we performed a meta-analysis using NetworkAnalyst (http://www.networkanalyst.ca), which is a comprehensive web-based tool designed to perform meta-analyses of gene expression data [20] .


id: cord-306835-juitltpi
author: Babaei, Fatemeh
title: Curcumin (a constituent of turmeric): New treatment option against COVID‐19
date: 2020-09-06
extension: .txt
mime: text/plain
words: 6247
sentence: 195
flesch: 30
cache: cache/cord-306835-juitltpi.txt
txt: txt/cord-306835-juitltpi.txt
summary:
  China Curcumin inhibits the replication of enterovirus 71 in vitro Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1 Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs Regulation of COX and LOX by curcumin ACE2 and pACE2: A pair of aces for pulmonary arterial hypertension treatment? Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis Curcumin downregulates human tumor necrosis factor-α levels: A systematic review and meta-analysis of randomized controlled trials Pinitol targets nuclear factor-kappaB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis Hydro-ethanolic extract of Curcuma longa affects tracheal responsiveness and lung pathology in ovalbumin-sensitized rats The multifaceted role of curcumin in cancer prevention and treatment Activation of transcription factor NFkappa B is suppressed by curcumin (diferuloylmethane) Y-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model Pre-treatment with curcumin ameliorates cisplatin-induced kidney damage by suppressing kidney inflammation and apoptosis in rats Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review From SARS to MERS, thrusting coronaviruses into the spotlight Intranasal curcumin and its evaluation in murine model of asthma Understanding of COVID-19 based on current evidence Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-β25-35 in rat cortical neurons Sina Hospital Covid-19 registry (SHCo-19R) Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells Targeting the renin-angiotensin system as novel therapeutic strategy for pulmonary diseases Pulmonary pathology of early-Phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer Effect of nuclear factor kappa B on intercellular adhesion molecule-1 expression and neutrophil infiltration in lung injury induced by intestinal ischemia/reperfusion in rats Renoprotective effect of the antioxidant curcumin: Recent findings Curcumin inhibits paraquat induced lung inflammation and fibrosis by extracellular matrix modifications in mouse model Protection from acute and chronic lung diseases by curcumin Clinical features and treatment of COVID-19 patients in northeast Chongqing Receptor recognition by the novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS coronavirus Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan Curcumin ameliorated ventilator-induced lung injury in rats Curcumin as a therapeutic agent for blocking NF-κB activation in ulcerative colitis Clinical features of 69 cases with coronavirus disease 2019 in Wuhan. Curcumin has low bioavailability, but a lot of data from clinical trials showed the high efficacy of curcumin or turmeric against several diseases (Kunnumakkara et al., 2019) .


id: cord-349201-d88g5toc
author: Yu, Feng
date: 2020-10-13
extension: .txt
mime: text/plain
words: 6163
sentence: 285
flesch: 44
cache: cache/cord-349201-d88g5toc.txt
txt: txt/cord-349201-d88g5toc.txt
title:
  Exploring the biomarkers associated with different host inflammation of acute respiratory distress syndrome (ARDS) from lung metabolomics in mice

summary:
  The severity of lung injury was evaluated. The four following indicators of lung injury were used to arrive at this score: alveolar congestion; bleeding; gap or vascular wall neutrophil infiltration or aggregation; and alveolar septal thickening or transparent membrane formation.


id: cord-016142-7j5cdt1b
author: Chiang, Eddie T.
date: 2010-06-28
extension: .txt
mime: text/plain
words: 16122
sentence: 624
flesch: 27
cache: cache/cord-016142-7j5cdt1b.txt
txt: txt/cord-016142-7j5cdt1b.txt
title:
  Acute Lung Injury: The Injured Lung Endothelium, Therapeutic Strategies for Barrier Protection, and Vascular Biomarkers

summary:
  [171] and to link S1P and its receptor ligation to enhanced vascular barrier regulation and demonstrated that physiological doses of S1P induce EC activation, marked cytoskeletal rearrangement, and stabilization of lung EC barrier function in vitro Finally, focal adhesions are intimately involved in lung EC barrier regulation via signaling between the cytoskeleton to the ECM.


id: cord-017217-zjab7o2o
author: Ali, Yousaf
title: Self Assessment Questions
date: 2008-01-08
extension: .txt
mime: text/plain
words: 9363
sentence: 674
flesch: 52
cache: cache/cord-017217-zjab7o2o.txt
txt: txt/cord-017217-zjab7o2o.txt
summary:
  Pseudogout is typically seen in older patients with preexisting degenerative joint disease, metabolic disease, or hyperparathyroidism, and no crystals have been observed. Semin Dial Management of carpal tunnel syndrome in renal dialysis patients using an extended carpal tunnel release procedure Comparison of Doppler echocardiography and right heart catheterization to assess pulmonary hypertension in systemic sclerosis Pulmonary hypertension in systemic autoimmune disease A 41-year-old female is referred due to 4 years of recurrent sinusitis.


id: cord-333520-v2sb90rc
author: Gardin, Chiara
date: 2020-08-26
extension: .txt
mime: text/plain
words: 10167
sentence: 362
flesch: 29
cache: cache/cord-333520-v2sb90rc.txt
txt: txt/cord-333520-v2sb90rc.txt
title:
  Could Mesenchymal Stem Cell-Derived Exosomes Be a Therapeutic Option for Critically Ill COVID-19 Patients?

summary:
  Several studies agree that reduced fibrosis and apoptosis of myocardial cells are other important effects of the EV-mediated ischemic cardiac repair Evidence from meta-analysis Cardiovascular disease and COVID-19 Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Inside the heart of COVID-19 Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study Clinical Characteristics of Coronavirus Disease 2019 in China COVID-19 and the cardiovascular system Mesenchymal stem cells and management of COVID-19 pneumonia Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury On the use of corticosteroids for 2019-nCoV pneumonia Coronaviruses and the cardiovascular system: Acute and long-term implications Treatment for emerging viruses: Convalescent plasma and COVID-19 Recommendations for Investigational COVID-19 Convalescent Plasma Chinese Clinical Trial Registry Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease: A Viewpoint on the Potential Influence of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on Onset and Severity of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus.


id: cord-309301-ai84el0j
author: Li, Yaqi
title: Organoid based personalized medicine: from bench to bedside
date: 2020-11-02
extension: .txt
mime: text/plain
words: 17488
sentence: 614
flesch: 31
cache: cache/cord-309301-ai84el0j.txt
txt: txt/cord-309301-ai84el0j.txt
summary:
  The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies Clevers H Wnt/Î²-Catenin Signaling, Disease, and Emerging Therapeutic Modalities TP53 mutations in human cancers: origins, consequences, and clinical use Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche In VitroPersonalized and Cancer Models to Guide Precision Medicine Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine Inflammatory Cytokine TNFÎ± Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure Sliced human cortical organoids for modeling distinct cortical layer formation Estes MK Epidemiology of human noroviruses and updates on vaccine development Jiang P Single Lgr5-or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo Genome-Scale CRISPR screening in human intestinal organoids identifies drivers of TGF-Î² Resistance Enhancer reprogramming promotes pancreatic cancer metastasis Development and application of human adult stem or progenitor cell organoids In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis Restifo NP Adoptive cell transfer as personalized immunotherapy for human cancer Organoid cultures for the analysis of cancer phenotypes A living biobank of breast cancer organoids captures disease heterogeneity Long-term expanding human airway organoids for disease modeling Establishment of patient-derived organoids and drug screening for biliary tract carcinoma Development of a functional thyroid model based on an organoid culture system MÃ¼ller A Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche Salmonella manipulation of host signaling pathways provokes cellular transformation associated with gallbladder carcinoma A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro Farin HF 3D model for CAR-mediated cytotoxicity using patientderived colorectal cancer organoids Tubuloids derived from human adult kidney and urine for personalized disease modeling Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients Human gastric cancer modelling using organoids Human pancreatic tumor organoids reveal loss of stem cell niche factor dependence during disease progression Recurrent R-spondin fusions in colon cancer Functional differentiation of alveolar type II epithelial cells in vitro: effects of cell shape, cell-matrix interactions and cellcell interactions Sato T Visualization and targeting of LGR5(+) human colon cancer stem cells Carcinoma of the gallbladder--is it a sequel of typhoid? For example, tumor organoids from colorectal cancer (CRC) can be selectively expanded upon withdrawal of Wnt3a and R-Spondin1.


id: cord-284332-p4c1fneh
author: Bosma, Karen J.
date: 2012-09-19
extension: .txt
mime: text/plain
words: 14538
sentence: 518
flesch: 29
cache: cache/cord-284332-p4c1fneh.txt
txt: txt/cord-284332-p4c1fneh.txt
title:
  Pharmacotherapy for Prevention and Treatment of Acute Respiratory Distress Syndrome: Current and Experimental Approaches

summary:
  The use of an inflammation-modulating diet in patients with acute lung injury or acute respiratory distress syndrome: a metaanalysis of outcome data Efficacy of an expanded ventilator bundle for the reduction of ventilatorassociated pneumonia in the medical intensive care unit Continuous aspiration of subglottic secretions in the prevention of ventilatorassociated pneumonia in the postoperative period of major heart surgery Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial Thromboprophylaxis in medicalsurgical critically ill patients Stress ulcer prophylaxis in critically ill patients: resolving discordant meta-analyses Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial Effects of physical training on functional status in patients with prolonged mechanical ventilation Recent trends in acute lung injury mortality: 1996-2005 Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis Effect of prone positioning in patients with acute respiratory distress syndrome: a metaanalysis Effect of mechanical ventilation in the prone position on clinical outcomes in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis1 Hemodynamic and gas exchange response to inhaled nitric oxide and prone positioning in acute respiratory distress syndrome patients High-frequency oscillatory ventilation in adults: the Toronto experience High-frequency oscillatory ventilation for adult patients with ARDS Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial Extracorporeal membrane oxygenation for 2009 influenza A (H1N1) acute respiratory distress syndrome Ketoconazole prevents acute respiratory failure in critically ill surgical patients A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome Development, implementation, and evaluation of a ketoconazole practice guideline for ARDS prophylaxis Angiotensin-converting enzyme inhibitor captopril prevents oleic acid-induced severe acute lung injury in rats Rosiglitazone attenuates the severity of sodium taurocholate-induced acute pancreatitis and pancreatitis-associated lung injury Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: phase IIb, multicenter, randomized, placebo-controlled, clinical trial Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial The Beta-Agonist Lung Injury Trial (BALTI): a randomized placebo-controlled clinical trial Randomized, placebo-controlled trial of an aerosolized beta-2 adrenergic agonist (albuterol) for the treatment of acute lung injury Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome: Exosurf Acute Respiratory Distress Syndrome Sepsis Study Group Bovine surfactant therapy for patients with acute respiratory distress syndrome Venticute in patients with pneumonia or aspiration of gastric contents and intubation/ventilation/oxygenation impairment (BY2001/M1-007) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome The American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury Arachidonic acid remodeling in human inflammatory cells migrating to the lung in vivo Recent advances in genetic predisposition to clinical acute lung injury Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock Pharmacotherapy of acute lung injury and acute respiratory distress syndrome Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients?


id: cord-014996-p6q0f37c
title: Posters_Monday_12 October 2009
date: 2009-08-06
extension: .txt
mime: text/plain
words: 85276
sentence: 4622
flesch: 51
cache: cache/cord-014996-p6q0f37c.txt
txt: txt/cord-014996-p6q0f37c.txt
summary:
  ICU patients with acute respiratory failure requiring NIV were studied during three randomized consecutive 20 min-periods of NIV: ICU ventilator with and without NIV mode and NIV ventilator. EFL was recorded in 65% of ICU patients with pulmonary diseases: 65 % of ARDS patients, 75% of patients with respiratory infection, 75% of asthmatics and 85% of patients with COPD.


# ent

id: cord-015384-bz7ui5a0
sid: 25
eid: 4
type: ORG
entity:
  oder septischer schock sowie deren intensivmedizinische therapiemodalitäten während des aufenthalts auf einer intensivstation


id: cord-015384-bz7ui5a0
sid: 26
eid: 1
type: PERSON
entity:
  langfristigen psychosozialen und psychologischen probleme als konsequenzen aus dieser erkrankung und dem notwendigen


id: cord-015384-bz7ui5a0
sid: 41
eid: 3
type: ORG
entity:
  einigen bedingungskonstellationen wie z. b. einer vorbestehenden alkoholabhängigkeit nicht nur ein erhöhtes


id: cord-015384-bz7ui5a0
sid: 43
eid: 6
type: ORG
entity:
  und narkotika mögliche und auch wahrscheinliche mechanismen einer vermittlung dieser kognitiven beeinträchtigungen andeuten


id: cord-015384-bz7ui5a0
sid: 46
eid: 2
type: ORG
entity:
  dass diese dauerhaften neurokognitiven defizite mit signifikanten einschränkungen der gesundheitsbezogenen lebensqualität


id: cord-015384-bz7ui5a0
sid: 59
eid: 1
type: ORG
entity:
  sowohl angst als auch depression bewirken im verlauf sehr häufig eine subjektive befundverschlimmerung


id: cord-015384-bz7ui5a0
sid: 85
eid: 16
type: PERSON
entity:
  eine nichtbeachtung von zwischenzeitlichen einflussfaktoren eine realistische einschätzung des ausmaßes eines


