item: #1 of 227 id: cord-000492-ec5qzurk author: Devaney, James title: Clinical Review: Gene-based therapies for ALI/ARDS: where are we now? date: 2011-06-20 words: 6021 flesch: 34 summary: Antibodies that bind antigens selectively expressed on the pulmonary endothelial surface can be complexed to gene vectors to facilitate selective targeting following intravenous administration + ,K + -ATPase rescues endotoxin-induced lung injury Interleukin-10 gene transfer: prevention of multiple organ injury in a murine cecal ligation and puncture model of sepsis Nonviral gene delivery with indoleamine 2,3-dioxygenase targeting pulmonary endothelium protects against ischemia-reperfusion injury Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, infl ammation, and neutrophil infl ux after hemorrhagic shock and sepsis Caveolin-1 siRNA increases the pulmonary microvascular and alveolar epithelial permeability in rats Interleukin-10 delivery via mesenchymal stem cells: a novel gene therapy approach to prevent lung ischemia-reperfusion injury Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fi brosis Cell-based gene transfer of vascular endothelial growth factor attenuates monocrotaline-induced pulmonary hypertension Microvascular regeneration in established pulmonary hypertension by angiogenic gene transfer Tetracycline-inducible transgene expression mediated by a single AAV vector Effi cient transfection of non-proliferating human airway epithelial cells with a synthetic vector system Tailoring the AAV vector capsid for gene therapy Artifi cial evolution with adeno-associated viral libraries Analysis and optimization of the cationic lipid component of a lipid/ peptide vector formulation for enhanced transfection in vitro and in vivo Stabilized integrin-targeting ternary LPD (lipopolyplex) vectors for gene delivery designed to disassemble within the target cell CpG-free plasmids confer reduced infl ammation and sustained pulmonary gene expression Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12 Targeting type II and Clara cells for adenovirus-mediated gene transfer using the surfactant protein B promoter Development of lentiviral vectors with regulated respiratory epithelial expression in vivo Expression of CFTR from a ciliated cell-specifi c promoter is ineff ective at correcting nasal potential diff erence in CF mice A human epithelium-specifi c vector optimized in rat pneumocytes for lung gene therapy Tight control of gene expression in mammalian cells by tetracycline-responsive promoters Use of a new generation reverse tetracycline transactivator system for quantitative control of conditional gene expression in the murine lung Construction of an rtTA2(s)-m2/ tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and non-human primates Adenoviral vector transfection into the pulmonary epithelium after cecal ligation and puncture in rats Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins aff ects the transduction effi ciency of recombinant vectors GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium Spatial and temporal expression of surfactant proteins in hyperoxia-induced neonatal rat lung injury Intrapulmonary TNF gene therapy reverses sepsis-induced suppression of lung antibacterial host defense Clinical Review: Gene-based therapies for ALI/ARDS: where are we now? keywords: ali; approaches; ards; cell; expression; gene; injury; lung; pulmonary; specifi; therapy; transfer; vectors cache: cord-000492-ec5qzurk.txt plain text: cord-000492-ec5qzurk.txt item: #2 of 227 id: cord-000498-absjerdt author: Hagau, Natalia title: Clinical aspects and cytokine response in severe H1N1 influenza A virus infection date: 2010-11-09 words: 5214 flesch: 47 summary: During the ICU hospitalization, critical patients with influenza virus infection (ARDS) received corticosteroid therapy (hydrocortisone or methylprednisolone). Th cells costimulated by intercellular adhesion molecule-1.I. IL-12 alters caspase processing and inhibits enzyme function Cytokine-mediated protection of human dendritic cells from prostate cancer-induced apoptosis is regulated by the Bcl-2 family of proteins Positive regulatory role of IL-12 in macrophages and modulation by IFN-gamma Influenza A virus-induced apoptosis in bronchiolar epithelial (NCI-H292) cells limits pro-inflammatory cytokine release IL-15 promotes the survival of naïve and memory phenotype CD8 + T cells IL-15 regulates CD8 + T cell contraction during primary infection Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8 + memory T cells Interleukin-17 and Type 17 helper T cells Th17 cells: effector T cells with inflammatory properties Innate immune control and regulation of influenza virus infections Plasma interleukin-8 concentrations are increased in obese subjects and related to fat mass and tumor necrosis factor-α system Chronic obstructive pulmonary disease: molecular and cellular mechanisms An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema IL-9 regulates pathology during primary and memory responses to respiratory syncytial virus infection Prolonged methylprednisolone treatment suppresses systemic inflammation in patients with unresolving acute respiratory distress syndrome. keywords: admission; ards; disease; group; il-6; il-8; infection; influenza; levels; nva(h1n1)-ards; patients cache: cord-000498-absjerdt.txt plain text: cord-000498-absjerdt.txt item: #3 of 227 id: cord-000539-uh3q65we author: Zhang, Yi title: Acute Respiratory Distress Syndrome Induced by a Swine 2009 H1N1 Variant in Mice date: 2012-01-03 words: 4631 flesch: 47 summary: The typical 2009 H1N1 virus, such as A/California/04/2009 (CA/04), can efficiently replicate in mouse lungs without prior host adaptation. Interferon (IFN)-c, monocyte chemotactic protein (MCP)-1, and tumor necrosis factor (TNF) dramatically increased in mouse lungs on days 6-8 p.i. keywords: ards; day; h1n1; infection; influenza; lung; mice; p.i; sd/09; virus cache: cord-000539-uh3q65we.txt plain text: cord-000539-uh3q65we.txt item: #4 of 227 id: cord-001215-aj8nxi3x author: Wang, Chen Yu title: One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome date: 2014-01-17 words: 4589 flesch: 38 summary: A multiple-center survey on the use in clinical practice of noninvasive ventilation as a first-line intervention for acute respiratory distress syndrome Non-invasive ventilation in community-acquired pneumonia and severe acute respiratory failure Neurally adjusted ventilatory assist (NAVA) improves patient-ventilator interaction during non-invasive ventilation delivered by face mask Early goaldirected therapy in the treatment of severe sepsis and septic shock Interventions to reduce mortality among patients treated in intensive care units Recommendations on basic requirements for intensive care units: structural and organizational aspects Mortality rates for patients with acute lung injury/ARDS have decreased over time Recent trends in acute lung injury mortality Acute respiratory distress syndrome: nationwide changes in incidence, treatment and mortality over 23 years Randomized, placebo-controlled clinical trial of an aerosolized beta-2 agonist for treatment of acute lung injury Changes in hospital mortality for United States intensive care unit admissions from Quality-adjusted survival in the first year after the acute respiratory distress syndrome One-year outcomes in survivors of the acute respiratory distress syndrome Twoyear outcomes, health care use, and costs of survivors of acute respiratory distress syndrome Survivors of acute respiratory distress syndrome: relationship between pulmonary dysfunction and long-term health-related quality of life The effect of pulmonary artery catheter use on costs and longterm outcomes of acute lung injury Lung protective mechanical ventilation and two year survival in patients with acute lung injury: prospective cohort study Identification of patients with acute lung injury. A multivariate analysis Pulmonary deadspace fraction as a risk factor for death in the acute respiratory distress syndrome Causes and timing of death in patients with ARDS Predictors of hospital mortality in a population-based cohort of patients with acute lung injury Predictors of mortality in acute lung injury during the era of lung protective ventilation A simple clinical predictive index for objective estimates of mortality in acute lung injury A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation Spanish Initiative for Epidemiology S, Therapies for AN (2013) keywords: ards; death; hospital; mortality; patients; survivors; term; year cache: cord-001215-aj8nxi3x.txt plain text: cord-001215-aj8nxi3x.txt item: #5 of 227 id: cord-001262-8s7g2wvd author: Zheng, Guoping title: Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study date: 2014-04-04 words: 4927 flesch: 46 summary: The acute respiratory distress syndrome Acute respiratory distress syndrome: epidemiology and management approaches Mesenchymal stem cells: a promising therapy for the acute respiratory distress syndrome Co-infusion of ex vivo-expanded, parental MSCs prevents life-threatening acute GVHD, but does not reduce the risk of graft failure in pediatric patients undergoing allogeneic umbilical cord blood transplantation A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction Double allogenic mesenchymal stem cells transplantations could not enhance therapeutic effect compared with single transplantation in systemic lupus erythematosus Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn's disease: results from a multicenter phase I/IIa clinical trial Age-related decline in the osteogenic potential of human bone marrow cells cultured in three-dimensional collagen sponges Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells Human bone marrow and adipose tissue mesenchymal stem cells: a user's guide Bone marrow-derived mesenchymal stem cells in repair of the injured lung Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1 Autologous transplantation of adipose-derived mesenchymal stem cells markedly reduced acute ischemia-reperfusion lung injury in a rodent model Human mesenchymal stem cells overexpressing the IL-33 antagonist sST2 attenuate endotoxin-induced acute lung injury Systemic human orbital fat-derived stem/stromal cell transplantation ameliorates acute inflammation in lipopolysaccharide-induced acute lung injury Acute respiratory distress syndrome: the Berlin Definition Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome: The acute respiratory distress syndrome network Nichol AD: A randomised controlled trial of an open lung strategy with staircase recruitment, titrated PEEP and targeted low airway pressures in patients with acute respiratory distress syndrome Bronchoalveolar and systemic cytokine profiles in patients with ARDS, severe pneumonia and cardiogenic pulmonary oedema Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials Network NARDSCT: lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury National heart L, blood institute acute respiratory distress syndrome clinical trials N: pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury Acute respiratory distress syndrome N: plasma surfactant protein levels and clinical outcomes in patients with acute lung injury Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect A placebo-controlled, randomized trial of mesenchymal stem cells in COPD Cytological and enzymological characterization of adult human adipocyte precursors in culture Multilineage cells from human adipose tissue: implications for cell-based therapies Mesenchymal stromal cells Adipose-derived mesenchymal stromal cells for chronic myocardial ischemia (MyStromalCell Trial): study design Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease Adipose tissue-derived mesenchymal stem cells are more potent suppressors of dendritic cells differentiation compared to bone marrow-derived mesenchymal stem cells Direct comparison of human mesenchymal stem cells derived from adipose tissues and bone marrow in mediating neovascularization in response to vascular ischemia Cotransplantation of adipose tissue-derived insulin-secreting mesenchymal stem cells and hematopoietic stem cells: a novel therapy for insulin-dependent diabetes mellitus Favorable response to human adipose tissue-derived mesenchymal stem cells in steroid-refractory acute graft-versus-host disease N-glycolylneuraminic acid xenoantigen contamination of human embryonic and mesenchymal stem cells is substantially reversible No alloantibodies against mesenchymal stromal cells, but presence of anti-fetal calf serum antibodies, after transplantation in allogeneic hematopoietic stem cell recipients Platelet lysate from whole blood-derived pooled platelet concentrates and apheresis-derived platelet concentrates for the isolation and expansion of human bone marrow mesenchymal stromal cells: production process, content and identification of active components Autologous serum for isolation and expansion of human mesenchymal stem cells for clinical use In vitro expansion of human mesenchymal stem cells: choice of serum is a determinant of cell proliferation, differentiation, gene expression, and transcriptome stability Development of fully defined xeno-free culture system for the preparation and propagation of cell therapy-compliant human adipose stem cells Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • keywords: acute; adipose; ards; cells; day; injury; lung; mesenchymal; mscs; patients; stem; study cache: cord-001262-8s7g2wvd.txt plain text: cord-001262-8s7g2wvd.txt item: #6 of 227 id: cord-001493-3yu2di1g author: Fujishima, Seitaro title: Pathophysiology and biomarkers of acute respiratory distress syndrome date: 2014-05-07 words: 3099 flesch: 31 summary: In the revised Berlin definition, the term ARDS was redefined as a broader concept including a milder condition of lung injury; therefore, it became equivalent to acute lung injury (ALI), which was the previous AECC definition. Persistent elevation over time predicts poor outcome Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials National Heart Blood, and Lung Institute Acute Respiratory Distress Syndrome Network: Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury Vascular endothelial growth factor in epithelial lining fluid of patients with acute respiratory distress syndrome Keratinocyte growth factor and hepatocyte growth factor in bronchoalveolar lavage fluid in acute respiratory distress syndrome patients Growth differentiation factor-15 and prognosis in acute respiratory distress syndrome: a retrospective cohort study Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients Neutrophil elastase and systemic inflammatory response syndrome in the initiation and development of acute lung injury among critically ill patients Role of diabetes in the development of acute respiratory distress syndrome* Diabetes, insulin, and development of acute lung injury Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferatoractivated receptor-{gamma} Hartl D: CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation DNA and inflammatory mediators in bronchoalveolar lavage fluid from children with acute inhalational injuries Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury Soluble form of P-selectin in plasma is elevated in acute lung injury Elevated plasma surfactant protein-B predicts development of acute respiratory distress syndrome in patients with acute respiratory failure Acute Respiratory Distress Syndrome Network: keywords: acute; ards; biomarkers; injury; levels; lung; patients; respiratory cache: cord-001493-3yu2di1g.txt plain text: cord-001493-3yu2di1g.txt item: #7 of 227 id: cord-001661-dj9bxhwb author: Kao, Kuo-Chin title: Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy date: 2015-05-15 words: 4386 flesch: 42 summary: Pathological findings of DAD patients had a higher hospital mortality rate than non-DAD patients (71.9 % vs 45.5 %, p = 0.007). A pathological finding of DAD in ARDS patients is associated with hospital mortality and there are no clinical characteristics that could identify DAD patients before open lung biopsy. keywords: acute; ards; biopsy; dad; distress; lung; patients; study; syndrome cache: cord-001661-dj9bxhwb.txt plain text: cord-001661-dj9bxhwb.txt item: #8 of 227 id: cord-001910-6zfz2ns5 author: Zhang, Xianming title: Abdominal Muscle Activity during Mechanical Ventilation Increases Lung Injury in Severe Acute Respiratory Distress Syndrome date: 2016-01-08 words: 3991 flesch: 49 summary: The purpose of this study was to test the hypothesis that abdominal muscle activity during mechanically ventilation increases lung injury in severe ARDS. After lung injury, Beagles were randomly assigned into spontaneous breathing group (BIPAP(SB)) and abdominal muscle paralysis group (BIPAP(AP)). keywords: ards; bipap; group; injury; lung; muscle; pressure; ventilation cache: cord-001910-6zfz2ns5.txt plain text: cord-001910-6zfz2ns5.txt item: #9 of 227 id: cord-001938-n2d5fw2f author: Ong, David S. Y. title: Cytomegalovirus reactivation and mortality in patients with acute respiratory distress syndrome date: 2016-03-01 words: 4487 flesch: 32 summary: CMV reactivation CMV reactivation occurred in 74 (27 %) of the included patients (Table 1 ). We aimed to estimate the attributable effect of CMV reactivation on mortality in immunocompetent ARDS patients. keywords: ards; cmv; disease; icu; mortality; patients; reactivation; study; time cache: cord-001938-n2d5fw2f.txt plain text: cord-001938-n2d5fw2f.txt item: #10 of 227 id: cord-002016-vzn338ub author: Thompson, B. Taylor title: Steroids are part of rescue therapy in ARDS patients with refractory hypoxemia: no date: 2016-02-16 words: 1258 flesch: 27 summary: key: cord-002016-vzn338ub authors: Thompson, B. Taylor; Ranieri, V. Marco title: Steroids are part of rescue therapy in ARDS patients with refractory hypoxemia: no date: 2016-02-16 journal: Intensive Care Med DOI: 10.1007/s00134-016-4255-1 sha: doc_id: 2016 cord_uid: vzn338ub nan Rescue therapies for acute respiratory distress syndrome (ARDS) usually target patients with severe hypoxia and/ or hypercarbia refractory to conventional therapies and are considered when rapid deterioration in the patient's condition over a period of hours suggests an increased risk of death. Under these circumstances conventional mechanical ventilation will almost certainly cause additional lung injury if rescue therapies are not implemented. keywords: ards; corticosteroids; patients; rescue cache: cord-002016-vzn338ub.txt plain text: cord-002016-vzn338ub.txt item: #11 of 227 id: cord-002078-38rmx65j author: Korkmaz Ekren, Pervin title: Can fiberoptic bronchoscopy be applied to critically ill patients treated with noninvasive ventilation for acute respiratory distress syndrome? Prospective observational study date: 2016-05-31 words: 3585 flesch: 41 summary: The primary outcome of this prospective observational study was to evaluate the feasibility, safety and contribution in diagnosis and/or modification of the ongoing treatment of fiberoptic bronchoscopy (FOB) in patients with ARDS treated with NIV. Appropriate treatment was decided according to the results of the bronchoscopic sampling in 20 (71.4 %) patients. keywords: acute; ards; bronchoscopy; failure; fob; niv; patients; study cache: cord-002078-38rmx65j.txt plain text: cord-002078-38rmx65j.txt item: #12 of 227 id: cord-002540-hgx0bfbz author: Chen, Chaolei title: Can glypican-3 be a disease-specific biomarker? date: 2017-05-16 words: 3095 flesch: 27 summary: Protocol of a longitudinal study Application of clinical bioinformatics in lung cancer-specific biomarkers Opportunities and challenges of disease biomarkers: a new section in the journal of translational medicine Isolation of a cDNA corresponding to a developmentally regulated transcript in rat intestine Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome The molecular diversity of glycosaminoglycans shapes animal development Glypican-3: a new target for cancer immunotherapy Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface Expression pattern of glypican-3 (GPC3) during human embryonic and fetal development Gpc3 expression correlates with the phenotype of the Simpson-Golabi-Behmel syndrome The loss of glypican-3 induces alterations in Wnt signaling Glypican-3 modulates BMP-and FGF-mediated effects during renal branching morphogenesis Boning up on glypicans-opportunities for new insights into bone biology Overexpression of GPC3 inhibits hepatocellular carcinoma cell proliferation and invasion through induction of apoptosis Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways Liver Metastases of Neuroendocrine Tumors Rarely Show Overlapping Immunoprofile with Hepatocellular Carcinomas Biofunctionalized magnetic nanospheres-based cell sorting strategy for efficient isolation, detection and subtype analyses of heterogeneous circulating hepatocellular carcinoma cells CK19 and glypican 3 expression profiling in the prognostic indication for patients with HCC after surgical resection MicroRNA-133b inhibits hepatocellular carcinoma cell progression by targeting Sirt1 Randomized phase II placebo controlled study of codrituzumab in previously treated patients with advanced hepatocellular carcinoma Glypican-3 is overexpressed in lung squamous cell carcinoma, but not in adenocarcinoma Utility of 10 immunohistochemical markers including novel markers (desmocollin-3, glypican 3, S100A2, S100A7, and Sox-2) for differential diagnosis of squamous cell carcinoma from adenocarcinoma of the Lung MicroRNA-133b is a small non-coding RNA which targets Sirt1s, suppressing its expression in hepatocellular carcinoma cells, increasing the proliferation and invasion of hepatocellular carcinoma cells through the activation of E-cadherin expression, and repressing expression of GPC3 and the anti-apoptotic proteins (Bcl-2, Bcl-xL, and Mcl-1) [26] . keywords: ards; carcinoma; cell; disease; glypican-3; gpc3; lung; patients; wnt cache: cord-002540-hgx0bfbz.txt plain text: cord-002540-hgx0bfbz.txt item: #13 of 227 id: cord-002782-mena480g author: Chen, Jiajia title: Long term outcomes in survivors of epidemic Influenza A (H7N9) virus infection date: 2017-12-08 words: 3055 flesch: 51 summary: However, there are no previous reports on the quality of life of H7N9 patients after hospital discharge. ARDS patients tended to stay longer in the hospital than non-ARDS patients. keywords: ards; follow; lung; patients; study; survivors cache: cord-002782-mena480g.txt plain text: cord-002782-mena480g.txt item: #14 of 227 id: cord-002801-6myqgme3 author: Yoon, Byung Woo title: Possible therapeutic effect of orally administered ribavirin for respiratory syncytial virus-induced acute respiratory distress syndrome in an immunocompetent patient: a case report date: 2017-12-20 words: 2564 flesch: 34 summary: Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis Respiratory syncytial virus infection in recipients of allogeneic stem-cell transplantation: a retrospective study of the incidence, clinical features, and outcome Clinical Practice Guideline of Acute Respiratory Distress Syndrome Acute respiratory distress syndrome: the Berlin Definition Respiratory syncytial virus infection: a cause of respiratory distress syndrome and pneumonia in adults Inhaled ribavirin therapy in adult respiratory syncytial virus-induced acute respiratory distress syndrome Respiratory syncytial virus infection in adults High morbidity and mortality in adults hospitalized for respiratory syncytial virus infections Rapid diagnosis of respiratory syncytial virus infections in immunocompromised adults Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use Respiratory Syncytial Virus Infection Control Challenges with a Novel Polymerase Chain Reaction Assay in a Comparison of the AdvanSure real-time RT-PCR and Seeplex(®) RV12 ACE assay for the detection of respiratory viruses Impact of a rapid respiratory panel test on patient outcomes Impact of Early Detection of Respiratory Viruses by Multiplex PCR Assay on Clinical Outcomes in Adult Patients Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature Respiratory viruses other than influenza virus: impact and therapeutic advances Oral ribavirin therapy for lower respiratory tract infection of respiratory syncytial virus complicating bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation Successful treatment of parainfluenza virus 3 pneumonia with oral ribavirin and methylprednisolone in a bone marrow transplant recipient Single-centre experience with oral ribavirin in lung transplant recipients with paramyxovirus infections An 81-year-old Korean man visited our out-patient clinic complaining of cough, dyspnea, and febrile sensation. This case demonstrates the potential usefulness of orally administered ribavirin as a therapeutic option for severe respiratory syncytial virus infection, at least in an immunocompetent host. keywords: case; infection; respiratory; ribavirin; rsv; virus cache: cord-002801-6myqgme3.txt plain text: cord-002801-6myqgme3.txt item: #15 of 227 id: cord-003198-1kw5v6rm author: Vuillard, Constance title: Clinical features and outcome of patients with acute respiratory failure revealing anti-synthetase or anti-MDA-5 dermato-pulmonary syndrome: a French multicenter retrospective study date: 2018-09-11 words: 4860 flesch: 36 summary: 22 Service de Réanimation médicale Unité de Réanimation et de Surveillance continue, Service de Pneumologie et Réanimation médicale, Groupe hospitalier Pitié-Salpêtrière, 47-83 bd de l'hôpital A contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients Do we need ARDS? Acute respiratory distress syndrome mimickers lacking common risk factors of the Berlin definition Etiologies, diagnostic work-up and outcomes of acute respiratory distress syndrome with no common risk factor: a prospective multicenter study Acute respiratory distress syndrome: the Berlin definition Diagnostic workup for ARDS patients Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries Anti-melanoma differentiation-associated protein 5-associated dermatomyositis: expanding the clinical spectrum Interstitial lung disease and anti-Jo-1 antibodies: difference between acute and gradual onset Dermato-pulmonary syndrome associated with MDA-5 antibodies A novel dermato-pulmonary syndrome associated with MDA-5 antibodies: report of 2 cases and review of the literature. Antisynthetase syndrome Clinical and serological aspects of patients with anti-Jo-1 antibodies-an evolving spectrum of disease manifestations Myositis specific autoantibodies: changing insights in pathophysiology and clinical associations Polymyositis, pulmonary fibrosis and autoantibodies to aminoacyl-tRNA synthetase enzymes Clinical manifestations and outcome of anti-PL7 positive patients with antisynthetase syndrome Sensitivity and specificity of anti-Jo-1 antibodies in autoimmune diseases with myositis Comparison of long-term outcome between anti-Jo1-and anti-PL7/PL12 positive patients with antisynthetase syndrome The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): a retrospective study Clinical features and outcomes of interstitial lung disease in anti-Jo-1 positive antisynthetase syndrome Acute respiratory failure in critically ill patients with interstitial lung disease Idiopathic pulmonary fibrosis: predicting response to therapy and survival Idiopathic pulmonary fibrosis: a composite physiologic index derived from disease extent observed by computed tomography Comparison of the Berlin definition for acute respiratory distress syndrome with autopsy The role of open-lung biopsy in ARDS keywords: acute; amda-5; anti; dermato; icu; lung; patients; pulmonary; syndrome cache: cord-003198-1kw5v6rm.txt plain text: cord-003198-1kw5v6rm.txt item: #16 of 227 id: cord-003219-iryb3v0z author: Kao, Kuo-Chin title: Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning date: 2018-09-24 words: 4380 flesch: 41 summary: [16] studied H7N9 influenza patients with prone positioning, and decrease in carbon dioxide retention was noted, but no clinical outcome was mentioned. Our previous study for severe ARDS patients with ECMO revealed that higher dynamic driving pressure [hazard ratio 1.070 (1.026-1.116), p = 0.002] during the first 3 days of ECMO was one of the factors independently associated with ICU mortality keywords: acute; ards; driving; influenza; patients; pneumonia; positioning; pressure; study cache: cord-003219-iryb3v0z.txt plain text: cord-003219-iryb3v0z.txt item: #17 of 227 id: cord-003397-fvrd128w author: Herath, H. M. L. Y. title: Spotted fever rickettsioses causing myocarditis and ARDS: a case from Sri Lanka date: 2018-12-29 words: 2555 flesch: 47 summary: He was confirmed to have spotted fever rickettsial infection with rising titre of indirect immunofluorescence antibodies to Ricketssia conorii and made a complete recovery with appropriate antibiotic therapy and supportive care. This case demonstrates a rather rare presentation of spotted fever rickettsial infection where patient deteriorated within short time leading to shock and ARDS. keywords: fever; infections; lanka; myocarditis; patient; rash; rickettsial; sri cache: cord-003397-fvrd128w.txt plain text: cord-003397-fvrd128w.txt item: #18 of 227 id: cord-003532-lcgeingz author: None title: 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date: 2019-03-19 words: 80115 flesch: 48 summary: Blood cultures were sent as per clinical & laboratory diagnosis of sepsis in ICU patients. Conclusions: HR, lactate levels and age before AVP initiation can predict the response to AVP in ICU patients with NE-resistant hypotension. keywords: acute; admission; age; aim; aki; analysis; arrest; arterial; assessment; baseline; blood; cardiac; care; care unit; cases; clinical; complications; conclusions; correlation; critical; data; days; diagnosis; difference; discharge; ecmo; effect; emergency; factors; failure; fig; figure; fluid; group; high; hospital; hospital mortality; hours; icu; icu admission; icu patients; ill; incidence; increase; injury; intensive; intervention; introduction; lactate; length; levels; low; lung; management; map; mean; median; medical; methods; months; mortality; non; organ; outcome; patients; patients introduction; period; post; pressure; rate; ratio; response; results; resuscitation; risk; score; sepsis; sepsis patients; septic; serum; severity; shock patients; sofa; stay; studies; study; surgery; survival; system; table; test; therapy; time; total; trauma; treatment; ultrasound; unit; use; ventilation; years cache: cord-003532-lcgeingz.txt plain text: cord-003532-lcgeingz.txt item: #19 of 227 id: cord-003615-vpzzsdld author: Thompson, Kelly B. title: Late immune consequences of combat trauma: a review of trauma-related immune dysfunction and potential therapies date: 2019-04-24 words: 8892 flesch: 30 summary: Incidence and epidemiology of combat injuries sustained during the surge portion of operation Iraqi freedom by a U.S. Army brigade combat team Combat musculoskeletal wounds in a US Army brigade combat team during operation Iraqi freedom Pelvic, spinal and extremity wounds among combat-specific personnel serving in Iraq and Afghanistan (2003-2011): a new paradigm in military musculoskeletal medicine An analysis of inhospital deaths at a modern combat support hospital Early prevention of trauma-related infection/ sepsis Inflammatory response is associated with critical colonization in combat wounds Blast injuries: mechanics and wounding patterns Negative pressure wound therapy in the management of combat wounds: a critical review Challenges of treating modern military trauma wounds Optimal use of blood in trauma patients The evolution of pain management in the critically ill trauma patient: emerging concepts from the global war on terrorism This tolerant phenotype was first described in trauma patients in the mid-1990s, where monocytes isolated from injured patients had a reduced cytokine response to ex vivo stimulation of endotoxins [27] . keywords: cells; combat; development; dysfunction; immune; infection; inflammatory; injuries; injury; mortality; patients; response; sepsis; syndrome; trauma; wound cache: cord-003615-vpzzsdld.txt plain text: cord-003615-vpzzsdld.txt item: #20 of 227 id: cord-003832-q1422ydi author: Koyama, Kansuke title: Biomarker profiles of coagulopathy and alveolar epithelial injury in acute respiratory distress syndrome with idiopathic/immune-related disease or common direct risk factors date: 2019-08-19 words: 4663 flesch: 34 summary: A secondary analysis of the LUNG SAFE study confirmed that 8.3% of ARDS patients had no common risk factors that were identified when ARDS was recognized [6] . Thrombin-antithrombin complex (TAT) levels are increased in ARDS patients, reflecting tissue factor-and contact phase-mediated activation of coagulation cascade and excessive thrombin generation. keywords: acute; ards; biomarkers; factors; injury; lung; patients; pneumonia; respiratory; risk; study cache: cord-003832-q1422ydi.txt plain text: cord-003832-q1422ydi.txt item: #21 of 227 id: cord-004067-psjyjvbu author: Zhou, Yile title: The regulatory effect of microRNA-21a-3p on the promotion of telocyte angiogenesis mediated by PI3K (p110α)/AKT/mTOR in LPS induced mice ARDS date: 2019-12-26 words: 5193 flesch: 44 summary: TCs culture medium enhanced hemangioendothelioma endothelial cells (EOMA cells) proliferation, which was blocked by the miR-21a-3p inhibitor. TCs proliferation was demonstrated to be regulated by transforming growth factor-β (TGF-β) and mediated by the PI3K p110α subunit and the PI3K/AKT/mTOR signalling pathway keywords: angiogenesis; ards; cells; culture; e2f8; expression; fig; inhibitor; lps; medium; mir-21a-3p; mirnas; p110α; pi3k; primer; proliferation; tcs cache: cord-004067-psjyjvbu.txt plain text: cord-004067-psjyjvbu.txt item: #22 of 227 id: cord-004092-wb150n8w author: Nieman, Gary F. title: Prevention and treatment of acute lung injury with time-controlled adaptive ventilation: physiologically informed modification of airway pressure release ventilation date: 2020-01-06 words: 8073 flesch: 43 summary: Summary of the experimental evidence for the clinical practice guideline Looking beyond macroventilatory parameters and rethinking ventilator-induced lung injury Airway pressure release ventilation reduces conducting airway micro-strain in lung injury Visualizing the propagation of acute lung injury Does regional lung strain correlate with regional inflammation in acute respiratory distress syndrome during nonprotective ventilation? An experimental porcine study Stress distribution in lungs: a model of pulmonary elasticity Alterations of mechanical properties and morphology in excised rabbit lungs rinsed with a detergent Physiology in Medicine: understanding dynamic alveolar physiology to minimize ventilator-induced lung injury Alveolar derecruitment and collapse induration as crucial mechanisms in lung injury and fibrosis Alveolitis and collapse in the pathogenesis of pulmonary fibrosis Mechanical ventilation-associated lung fibrosis in acute respiratory distress syndrome: a significant contributor to poor outcome Opening pressures and atelectrauma in acute respiratory distress syndrome Does high PEEP prevent alveolar cycling? Effect of lung recruitment and titrated positive endexpiratory pressure (PEEP) vs low PEEP on mortality in patients with acute respiratory distress syndrome: a randomized clinical trial Alveolar instability (atelectrauma) is not identified by arterial oxygenation predisposing the development of an occult ventilatorinduced lung injury Effects of respiratory rate, plateau pressure, and positive end-expiratory pressure on PaO2 oscillations after saline lavage A fibre optic oxygen sensor that detects rapid PO2 changes under simulated conditions of cyclical atelectasis in vitro Unstable inflation causing injury: insight from prone position and paired CT scans Deterioration of regional lung strain and inflammation during early lung injury Tidal changes on CT and progression of ARDS Lung inhomogeneities and time course of ventilator-induced mechanical injuries Mechanical breath profile of airway pressure release ventilation: the effect on alveolar recruitment and microstrain in acute lung injury Effect of airway pressure release ventilation on dynamic alveolar heterogeneity Mechanisms of surface-tensioninduced epithelial cell damage in a model of pulmonary airway reopening The influence of non-equilibrium surfactant dynamics on the flow of a semi-infinite bubble in a rigid cylindrical capillary tube Biomechanics of liquid-epithelium interactions in pulmonary airways Tidal ventilation at low airway pressures can augment lung injury Airway closure in acute respiratory distress syndrome: an underestimated and misinterpreted phenomenon Alveolar volume-surface area relation in air-and saline-filled lungs fixed by vascular perfusion Influence of forced inflations on the creep of lungs and thorax in the dog Alveolar micromechanics in bleomycin-induced lung injury Lung inhomogeneity in patients with acute respiratory distress syndrome Micromechanics of alveolar edema Local strain distribution in real three-dimensional alveolar geometries Stress concentration around an atelectatic region: a finite element model Acute respiratory distress syndrome Never give the lung the opportunity to collapse Preemptive mechanical ventilation based on dynamic physiology in the alveolar microenvironment: novel considerations of time-dependent properties of the respiratory system Last Word on Viewpoint: looking beyond macroventilatory parameters and rethinking ventilator-induced lung injury Regional behavior of airspaces during positive pressure reduction assessed by synchrotron radiation computed tomography The effect of positive end-expiratory pressure on lung micromechanics assessed by synchrotron radiation computed tomography in an animal model of ARDS Dynamic mechanical interactions between neighboring airspaces determine cyclic opening and closure in injured lung Individual airway closure characterized in vivo by phase-contrast ct imaging in injured rabbit lung Ventilator-induced lung injury and lung mechanics Limiting ventilator-associated lung injury in a preterm porcine neonatal model Early application of airway pressure release ventilation may reduce mortality in high-risk trauma patients: a systematic review of observational trauma ARDS literature Alveolar leak develops by a rich-get-richer process in ventilatorinduced lung injury Lung tissue viscoelasticity: a mathematical framework and its molecular basis Lung parenchymal mechanics Lung parenchymal mechanics in health and disease Modeling the complex dynamics of derecruitment in the lung Respiratory mechanics in anesthetized paralyzed humans: effects of flow, volume, and time Differential susceptibility of diaphragm muscle fibers to neuromuscular transmission failure Lung mechanics. keywords: acute; airway; alveolar; collapse; expiratory; fig; lung; phase; pressure; release; tcav; time; ventilation cache: cord-004092-wb150n8w.txt plain text: cord-004092-wb150n8w.txt item: #23 of 227 id: cord-004385-xna32qve author: Zhou, Yuqing title: Use of corticosteroids in influenza-associated acute respiratory distress syndrome and severe pneumonia: a systemic review and meta-analysis date: 2020-02-20 words: 4497 flesch: 36 summary: The small number of included studies and the small number of patients in the included studies might also make the effect size of some outcome indicators insufficient, and we were unable to analyse the effect of some factors on the outcome indicators by meta-regression or subgroup analysis. In a study of 2141 patients with severe influenza pneumonia 15 , 245 patients had nosocomial infection, and the most commonly isolated pathogens were Acinetobacter baumannii (35.0%), Pseudomonas aeruginosa (13.5%), and Staphylococcus aureus (11.0%), while in another cohort study of 1846 patients with severe influenza pneumonia 8 , Streptococcus pneumoniae (49.1%), Pseudomonas aeruginosa (10.1%), and Staphylococcus aureus (7.5%) were the most frequently isolated microorganisms. keywords: analysis; corticosteroid; influenza; mortality; patients; pneumonia; studies; study cache: cord-004385-xna32qve.txt plain text: cord-004385-xna32qve.txt item: #24 of 227 id: cord-004450-daxz9yhp author: Haeberle, Helene title: Therapeutic iloprost for the treatment of acute respiratory distress syndrome (ARDS) (the ThIlo trial): a prospective, randomized, multicenter phase II study date: 2020-03-04 words: 5858 flesch: 36 summary: X a X a X a X a X a X a X a Fluid balance X a X a X a X a X a X a X a Transfusion of red blood cells X X X X X X X b X X X Transfusion of thrombocytes X X X X X X X b X X X Anticoagulation Infection X X X X X X X b X X X Anti-infective therapy X X X X X X X b X X X When possible, however, the patient or his legal representative is to be informed both in writing and verbally by the investigator before any study-specific procedure is Iloprost or NaCl 0.9% (control) X X X X X Clinical assessment including outcome X X X X X X X X X Laboratory testing X X X X X X X X Adverse/serious adverse event monitoring X X X X X X X Plasma biomarkers X X X X X X Barthel Index X X X X SOFA score keywords: acute; ards; day; effect; iloprost; injury; lung; patients; pulmonary; study; treatment; trial; ventilation cache: cord-004450-daxz9yhp.txt plain text: cord-004450-daxz9yhp.txt item: #25 of 227 id: cord-004462-e8fbg6i6 author: Liu, Songqiao title: Optimal mean airway pressure during high-frequency oscillatory ventilation in an experimental model of acute respiratory distress syndrome: EIT-based method date: 2020-03-06 words: 3652 flesch: 45 summary: EIT-based COV index higher than 50% at high mPaw steps indicated ventilation distribution toward gravity-dependent regions. The differences of impedance between lower mPaw and higher mPaw were calculated. keywords: distribution; eit; hfov; lung; mpaw; optimal; regions; study; ventilation cache: cord-004462-e8fbg6i6.txt plain text: cord-004462-e8fbg6i6.txt item: #26 of 227 id: cord-004515-x22q1f21 author: Pottecher, Julien title: Protocol for TRAUMADORNASE: a prospective, randomized, multicentre, double-blinded, placebo-controlled clinical trial of aerosolized dornase alfa to reduce the incidence of moderate-to-severe hypoxaemia in ventilated trauma patients date: 2020-03-18 words: 6820 flesch: 38 summary: The primary trial objective is to demonstrate a reduction in the incidence of moderate-to-severe hypoxaemia in severe trauma patients during the first 7 days from 45% to 30% by providing aerosolized dornase alfa as compared to placebo. This treatment may facilitate ventilator weaning, reduce the burden of trauma-induced lung inflammation and facilitate recovery and rehabilitation in severe trauma patients. keywords: alfa; analysis; blood; data; day; days; dna; dornase; hypoxaemia; incidence; injury; lung; patients; study; trauma; trial; variables cache: cord-004515-x22q1f21.txt plain text: cord-004515-x22q1f21.txt item: #27 of 227 id: cord-004532-flo9139j author: Andrews, Peter title: Year in review in intensive care medicine, 2004. I. Respiratory failure, infection, and sepsis date: 2004-12-18 words: 9265 flesch: 40 summary: Last, intrahospital transport poses an important risk to ICU patients. Periextubation pain has received little attention in ICU patients. keywords: acute; authors; care; colonization; failure; icu; infection; intensive; lung; mortality; patients; study; vap; weaning cache: cord-004532-flo9139j.txt plain text: cord-004532-flo9139j.txt item: #28 of 227 id: cord-005511-h5d2v4ga author: Ospina-Tascón, Gustavo A. title: Microcirculatory dysfunction and dead-space ventilation in early ARDS: a hypothesis-generating observational study date: 2020-03-24 words: 5223 flesch: 43 summary: Definitions, mechanisms, relevant outcomes, and clinical trial coordination Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury Lung injury etiology and other factors influencing the relationship between deadspace fraction and mortality in ARDS Effects of positive end-expiratory pressure on gas exchange in dogs with normal and edematous lungs Functional heterogeneity of oxygen supply-consumption ratio in the heart Microvascular blood flow is altered in patients with sepsis Monitoring the microcirculation in the critically ill patient: current methods and future approaches Measuring microvascular blood flow in sepsis-a continuing challenge An early PEEP/FIO 2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome Screening of ARDS patients using standardized ventilator settings: influence on enrollment in a clinical trial How large is the lung recruitability in early acute respiratory distress syndrome: a prospective case series of patients monitored by computed tomography Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndrome Calculation of physiologic dead space: comparison of ventilator volumetric capnography to measurements by metabolic analyzer and volumetric CO 2 monitor How to evaluate the microcirculation: report of a round table conference Pathologic features and mechanisms of hypoxemia in adult respiratory distress syndrome Lung structure and function in different stages of severe adult respiratory distress syndrome Redistribution of pulmonary blood flow in the dog with PEEP ventilation The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial Lung inhomogeneity in patients with acute respiratory distress syndrome Microvascular perfusion as a target for fluid resuscitation in experimental circulatory shock Early bedside detection of pulmonary vascular occlusion during acute respiratory failure Vascular obstruction causes pulmonary hypertension in severe acute respiratory failure Alterations of the gas exchange apparatus in adult respiratory insufficiency associated with septicemia The pulmonary vascular lesions of the adult respiratory distress syndrome Relationship between capillary and systemic venous PO 2 during nonhypoxic and hypoxic ventilation Mechanisms of physiological dead space response to PEEP after acute oleic acid lung injury Assessment of dead-space ventilation in patients with acute respiratory distress syndrome: a prospective observational study Effect of anatomic shunt on physiologic deadspace-to-tidal volume ratio-a new equation Rationale of dead space measurement by volumetric capnography Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP) vs low PEEP on mortality in patients with acute respiratory distress syndrome: a randomized clinical trial Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations We sought to evaluate the relationships between dynamic variations in V(D)/V(T) and extra-pulmonary microcirculatory blood flow detected at sublingual mucosa hypothesizing that an altered microcirculation, which is a generalized phenomenon during severe inflammatory conditions, could influence ventilation/perfusion mismatching manifested by increases in V(D)/V(T) fraction during early stages of ARDS. keywords: ards; blood; flow; fraction; pulmonary; space; ventilation cache: cord-005511-h5d2v4ga.txt plain text: cord-005511-h5d2v4ga.txt item: #29 of 227 id: cord-005572-zdzeqc19 author: Agarwal, Ritesh title: Experience with ARDS caused by tuberculosis in a respiratory intensive care unit date: 2005-07-09 words: 2204 flesch: 39 summary: Also delayed treatment is known to contribute to mortality in ICU patients with pulmonary TB and acute respiratory failure [5] . The acute respiratory distress syndrome Epidemiology Tuberculosis as a primary cause of respiratory failure requiring mechanical ventilation Acute respiratory distress syndrome (ARDS) in miliary tuberculosis: a twelve-year experience Delayed treatment contributes to mortality in ICU patients with severe active pulmonary tuberculosis and acute respiratory failure Miliary tuberculosis and acute respiratory distress syndrome Patient mortality of active pulmonary tuberculosis requiring mechanical ventilation Epidemiology and prognosis of acute respiratory distress syndrome Definitions, mechanisms, relevant outcomes, and clinical trial coordination Molecular biology, virulence, and pathogenicity of mycobacteria Hemodynamic confirmation of septic shock in disseminated tuberculosis Clinical and High-resolution computed tomographic findings in five patients with pulmonary tuberculosis who developed respiratory failure following chemotherapy Clinical profile, laboratory characteristics and outcome in miliary tuberculosis Indications of BAL, lung biopsy, or both in mechanically ventilated patients with unexplained infiltrations Adult respiratory distress syndrome in the tropics keywords: ards; cause; patients; tuberculosis cache: cord-005572-zdzeqc19.txt plain text: cord-005572-zdzeqc19.txt item: #30 of 227 id: cord-005573-mryrl1s1 author: Raimondi, Francesco title: Point-of-care lung ultrasound in neonatology: classification into descriptive and functional applications date: 2018-07-20 words: 5979 flesch: 34 summary: Authors' reply Lung ultrasound findings in meconium aspiration syndrome Lung ultrasonography to diagnose meconium aspiration syndrome of the newborn Bedside ultrasonography for diagnosis of pneumothorax Pleural ultrasonography versus chest radiography for the diagnosis of pneumothorax: review of the literature and meta-analysis Lung ultrasound-guided emergency pneumothorax needle aspiration in a very preterm infant Lung ultrasound diagnostic accuracy in neonatal pneumothorax Lung ultrasonography to diagnose pneumothorax of the newborn Lung ultrasound for diagnosing pneumothorax in the critically ill neonate Lung ultrasound: an useful tool for the follow-up of neonatal localized interstitial emphysema Pneumomediastinum as a sonographic mimic of pneumothorax The still lung point: new sonographic evidence for pneumomediastinum Lung ultrasonography for the diagnosis of severe neonatal pneumonia Routine application of lung ultrasonography in the neonatal intensive care unit Lung ultrasound for the diagnosis of pneumonia in children: a meta-analysis Systematic review and meta-analysis for the use of ultrasound versus radiology in diagnosing of pneumonia Lung ultrasound for the diagnosis of pneumonia in adults: a metaanalysis Accuracy and applications of lung ultrasound to diagnose ventilator-associated pneumonia: a systematic review Lung ultrasound in bronchiolitis: comparison with chest X-ray Can a simple lung ultrasound score predict length of ventilation for infants with severe acute viral bronchiolitis? Acute respiratory distress syndrome caused by respiratory syncytial virus Point-of-care lung ultrasound in young children with respiratory tract infections and wheeze Lung ultrasound: a useful tool in diagnosis and management of bronchiolitis The role of lung ultrasound in viral lower respiratory tract infections Prospective application of clinicianperformed lung ultrasonography during the 2009 H1N1 influenza A pandemic: distinguishing viral from bacterial pneumonia Dynamic assessment of lung injury by ultrasound in a case with H7N9 influenza Early recognition of the 2009 pandemic influenza A (H1N1) pneumonia by chest ultrasound Sonographic detection of radio-occult interstitial lung involvement in measles pneumonitis Variables associated with the early failure of nasal CPAP in very low birth weight infants Reliability of CXR for the diagnosis of bronchopulmonary dysplasia Sonographic prediction of chronic lung disease in the premature undergoing mechanical ventilation The value of ultrasound examination of the lungs in predicting bronchopulmonary dysplasia Chronic pulmonary insufficiency of prematurity: developing optimal endpoints for drug development Prenatal and postnatal management of congenital pulmonary airway malformation Lung ultrasound findings in congenital pulmonary airway malformations BLUE-protocol and FALLS-protocol: two applications of lung ultrasound in the critically ill Chest ultrasound in acute respiratory distress syndrome Can neonatal lung ultrasound monitor fluid clearance and predict the need of respiratory support? Use of neonatal chest ultrasound to predict noninvasive ventilation failure Lung ultrasound as a predictor of mechanical ventilation in neonates older than 32 weeks Bedside ultrasound assessment of positive end-expiratory pressure-induced lung recruitment Lung ultrasound in the ICU: from diagnostic instrument to respiratory monitoring tool Lung ultrasonography score to evaluate oxygenation and surfactant need in neonates treated with continuous positive airway pressure Point-of-care lung ultrasound in neonatology: classification into Lung ultrasound score predicts surfactant need in extremely preterm neonates Detection of abnormalities in ultrasound lung image using multi-level RVM classification Fetal Lung Texture Team. A prospective international study Clinical data are essential to validate lung ultrasound Diagnosis of neonatal transient tachypnea and its differentiation from respiratory distress syndrome using lung ultrasound Lung ultrasound in respiratory distress syndrome: a useful tool for early diagnosis Diagnostic performance of point of care ultrasonography in identifying the etiology of respiratory distress in neonates Neonatal lung sonography: interobserver agreement between physician interpreters with varying levels of experience Use of lung ultrasound in detection of complications of respiratory distress syndrome Lung ultrasonography of pulmonary complications in preterm infants with respiratory distress syndrome. keywords: care; chest; diagnosis; findings; lung; lus; neonatal; neonates; point; syndrome; ultrasound; use cache: cord-005573-mryrl1s1.txt plain text: cord-005573-mryrl1s1.txt item: #31 of 227 id: cord-005577-uk5wzk6m author: Bachmann, D. C. G. title: Respiratory syncytial virus triggered adult respiratory distress syndrome in infants: A report of two cases date: 1994 words: 1395 flesch: 43 summary: key: cord-005577-uk5wzk6m authors: Bachmann, D. C. G.; Pfenninger, J. title: Respiratory syncytial virus triggered adult respiratory distress syndrome in infants: A report of two cases date: 1994 journal: Intensive Care Med DOI: 10.1007/bf02425060 sha: doc_id: 5577 cord_uid: uk5wzk6m Two infants with severe respiratory syncytial virus infection which resulted eventually in classical adult respiratory distress syndrome (ARDS) are presented. During the winter 1990/91 we treated two infants in whom RSV infection triggered severe adult respiratory distress syndrome (ARDS). keywords: ards; day; infants; respiratory cache: cord-005577-uk5wzk6m.txt plain text: cord-005577-uk5wzk6m.txt item: #32 of 227 id: cord-005583-hmv8jjfl author: Peters, M. J. title: Acute hypoxemic respiratory failure in children: case mix and the utility of respiratory severity indices date: 2013-12-27 words: 3993 flesch: 38 summary: [18] , that other markers sought. of ventilation-related outcome should be Adult respiratory distress syndrome in a pediatric intensive care unit: predisposing conditions, clinical course and outcome Predictors of mortality in children with respiratory failure: possible indications for ECMO Alveolar-arterial oxygen gradient as a predictor of outcome in patients with non-neonatal respiratory failure Mortality rates and prognostic variables in children with adult respiratory distress syndrome Adult respiratory distress syndrome in children: associated diseases, clinical course and predictors of death Fackler JC and the Pediatric Critical Care Study Group and the Extracorporeal Life Support Organisation (1995) Predicting death in pediatric patients with acute respiratory failure Acute respiratory distress syndrome caused by respiratory syncytial virus Early response to inhaled nitric oxide and its relationship to outcome in children with severe hypoxemic respiratory failure Predicting outcome in children with severe acute respiratory failure treated with high-frequency ventilation The American-European consensus conference on ARDS: Definitions, mechanisms, relevant outcomes and clinicai trial coordination Outcome of pediatric patients with multiple organ system failure Arterial oxygenation does not predict the outcome of patients with acute respiratory failure needing mechanical ventilation Is outcome from ARDS related to the severity of respiratory failure? Outcome from mechanical ventilation PRISM III: An updated pediatric risk of mortality score Wilkinson K (1997) keywords: ahrf; care; children; failure; mortality; outcome; patients; study cache: cord-005583-hmv8jjfl.txt plain text: cord-005583-hmv8jjfl.txt item: #33 of 227 id: cord-005621-a4bspoii author: Roch, Antoine title: Outcome of acute respiratory distress syndrome patients treated with extracorporeal membrane oxygenation and brought to a referral center date: 2013-10-30 words: 4717 flesch: 45 summary: Of note, most of our patients had pneumonia with severe septic shock requiring vasopressors, and half of them required renal replacement therapy during the ICU stay, which has been shown to have an important prognostic impact in ECMO patients However, no study had previously clearly shown a protective effect of influenza in ECMO patients. keywords: ards; ecmo; extracorporeal; hospital; mortality; patients; score; sofa; study cache: cord-005621-a4bspoii.txt plain text: cord-005621-a4bspoii.txt item: #34 of 227 id: cord-005646-xhx9pzhj author: None title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 words: 72090 flesch: 51 summary: Objective: To assess the normal ,gastric intramucosal pH ~Hi) by tonometry in healthy children Patients and methods: Twelve healthy children (6 males and 6 females) with age rmaged from 6 months to 12 years scheduled for minor plastic or urologic surgery. Pain relief was good (VRS less 2) in 53 children -94.6 % of study patients. keywords: acute; administration; admission; age; airway; analysis; ards; arterial; average; babies; blood; brain; cardiac; care; cases; changes; chest; children; complications; conclusion; cpb; criteria; data; days; death; diagnosis; difference; disease; dose; drug; duration; ecmo; effects; failure; flow; gas; group; heart; high; hospital; hours; hypertension; icu; ill; incidence; increase; infants; infusion; initial; injury; intensive; levels; life; lung; management; mean; measurements; mechanical; median; medical; methods; minutes; months; mortality; neonatal; neonates; newborns; nitric; non; nurses; outcome; oxide; oxygenation; parameters; patients; peak; pediatric; period; phi; picu; plasma; post; present; pressure; prism; pulmonary; range; rate; response; results; risk; score; sepsis; severe; severity; study; support; surgery; survivors; syndrome; system; test; therapy; time; total; treatment; unit; use; values; ventilation; volume; weeks; weight; years cache: cord-005646-xhx9pzhj.txt plain text: cord-005646-xhx9pzhj.txt item: #35 of 227 id: cord-005686-k6t1q7q6 author: Hassett, Patrick title: Overexpression of pulmonary extracellular superoxide dismutase attenuates endotoxin-induced acute lung injury date: 2011-07-14 words: 3770 flesch: 35 summary: The AAV vector itself did not contribute to inflammation or to lung injury. One animal in each endotoxin injury group died following induction of anaesthesia for final injury assessment, immediately prior to assessment of physiologic indices of lung injury, due to the severity of their lung injury. keywords: animals; ards; endotoxin; injury; lung; overexpression; sod; superoxide; vector; vehicle cache: cord-005686-k6t1q7q6.txt plain text: cord-005686-k6t1q7q6.txt item: #36 of 227 id: cord-005699-uf59ls0g author: Leclerc, F. title: Inhaled nitric oxide for a severe respiratory syncytial virus infection in an infant with bronchopulmonary dysplasia date: 1994 words: 1485 flesch: 42 summary: Respiratory syncytial virus (RSV) causes lower respiratory tract infections (bronchiolitis and/or pneumonia) that are more often severe in children with bronchopulmonary dysplasia (BPD) Respiratory syncytial virus puzzle: clinical features, pathophysiology, treatment, and prevention Respiratory syncytial virus infection in children with bronchopulmonary dysplasia A controlled trial of aerosolized ribavirin in infants receiving mechanical ventilation for severe respiratory syncytial virus infection Use of extracorporeal membrane oxygenation in the treatment of respiratory syncytial virus bronchiolitis: the national experience Inhaled nitric oxide for the adult respiratory distress syndrome Comparison of respiratory mechanics measurements during volume and pressure controlled ventilation in neonates Inhaled nitric oxide. keywords: ards; days; ppm cache: cord-005699-uf59ls0g.txt plain text: cord-005699-uf59ls0g.txt item: #37 of 227 id: cord-005705-j765ruj1 author: Dreyfuss, Didier title: Is it better to consent to an RCT or to care?: Μηδεν αγαν (“nothing in excess”) date: 2004-12-17 words: 7512 flesch: 42 summary: United States Government Printing Office Unraveling the Tuskegee study of untreated syphilis The therapeutic orientation to clinical trials The integral role of clinical research in clinical care Is informed consent always necessary for randomized, controlled trials? Resolving discordant meta-analyses Clinically significant gastrointestinal bleeding in critically ill patients with and without stress-ulcer prophylaxis Clinicians' approaches to mechanical ventilation in acute lung injury and ARDS The price of autonomy Principles of medical ethics Why immunomodulatory therapies have not worked in sepsis Safeguarding patients in clinical trials with high mortality rates Is the concept of informed consent applicable to clinical research involving critically ill patients? Ethical considerations for research in critically ill patients Do surrogate decision makers provide accurate consent for intensive care research? keywords: ards; care; consent; evidence; investigators; patients; rcts; research; studies; study; trials; validity cache: cord-005705-j765ruj1.txt plain text: cord-005705-j765ruj1.txt item: #38 of 227 id: cord-005777-6rvfsx4p author: None title: PS 0420-0716 date: 2007-08-25 words: 59296 flesch: 50 summary: The aim of this study was to determine the risk factors and mortality rate of acinetobacter baumanii infections in ICU patients. It has been considered to play a role in worsening the prognosis of ICU patients. keywords: acute; admission; age; aim; analysis; apache; ards; ards patients; arterial; blood; cardiac; care; cases; complications; conclusion; control; data; days; dose; factors; failure; function; group; hospital; hours; icu; icu mortality; icu patients; incidence; increase; infection; infusion; injury; intensive; lactate; length; levels; liver; lung; mean; median; medical; mortality; non; outcome; parameters; patients; peep; period; pneumonia; pressure; pts; pulmonary; rate; ratio; results; risk; score; sepsis; septic; serum; shock; stay; study; surgery; test; therapy; time; total; tracheostomy; treatment; unit; use; values; ventilation; years cache: cord-005777-6rvfsx4p.txt plain text: cord-005777-6rvfsx4p.txt item: #39 of 227 id: cord-005812-hx6lkuj0 author: Morty, Rory E. title: Alveolar fluid clearance in acute lung injury: what have we learned from animal models and clinical studies? date: 2007-05-25 words: 6238 flesch: 32 summary: The acute respiratory distress syndrome Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome Lung epithelial fluid transport and the resolution of pulmonary edema Alveolar edema must be cleared for the acute respiratory distress syndrome patient to survive Function of the alveolar epithelial barrier under pathologic conditions Sodium channels in alveolar epithelial cells: molecular characterization, biophysical properties, and physiological significance Invited review: lung edema clearance: role of Na (+)-K (+)-ATPase Novel role for CFTR in fluid absorption from the distal airspaces of the lung RNA interference for alpha-ENaC inhibits rat lung fluid absorption in vivo Alterations of the gas exchange apparatus in adult respiratory insufficiency associated with septicemia Mechanisms of alveolar epithelial repair in acute lung injury-a translational approach Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema Alveolar epithelium: role in lung fluid balance and acute lung injury Alveolar epithelial barrier functions in ventilated perfused rabbit lungs Oleic acid inhibits alveolar fluid reabsorption: a role in acute respiratory distress syndrome? The AFC block was attributed to impaired sodium transport resulting from decreased membrane abundance of the Na,K-ATPase in rat lungs keywords: afc; ali; alveolar; ards; atpase; edema; fluid; lung; sodium; transport cache: cord-005812-hx6lkuj0.txt plain text: cord-005812-hx6lkuj0.txt item: #40 of 227 id: cord-005814-ak5pq312 author: None title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 words: 179325 flesch: 51 summary: Leukemia inhibitory factor (LIF), a growth factor recently recognised as a polyfunctional cytokine integrated in cytokine networks was measured in unconcentrated BALF of patients from different patient groups. It is difficult to generalize on intensive care units as different patient groups are in different ICUs aud there are great changes from one hospital to another and from one country to another. keywords: activity; acute; administration; admission; adult patients; age; aim; airway; analysis; apache; application; ards patients; arf; arterial; artery; assess; average; baseline; blood; blood flow; blood pressure; blood volume; breathing; cardiac; care patients; care unit; cases; catheter; cerebral; changes; chest; children; clinical; compliance; complications; concentration; conclusions; conditions; constant; control group; control patients; copd patients; correlation; course; cpb; criteria; critical; cvp; daily; damage; data; days; death; death patients; decrease; diagnosis; difference; disease; dose; drugs; duration; dysfunction; effect; emergency; end; evaluation; exchange; factors; failure; failure patients; findings; flow; fluid; following; frequency; function; gas; gastric; general; good; group; group b; group ii; group patients; h20; head; heart; hemodynamic; hepatic; hospital; hours; hypertension; icp; icu patients; iii; ill; illness; improvement; incidence; increase; index; infection; influence; infusion; injury; intensive; introduction; intubation; lactate; left; levels; life; liver; lung; male; management; map; mean; measurements; median; medical; methods; min; minutes; mmhg; model; monitoring; mortality; mortality rate; muscle; myocardial; need; negative; new; non; normal; number; objectives; onset; operation; order; organ; outcome; output; oxygen; oxygenation; p =; p<0.05; pao2; parameters; patients; patients methods; pattern; peep; perfusion; period; phase; phi; plasma; population; position; postoperative; presence; present; pressure; pressure support; procedure; protocol; pts; pulmonary; rain; range; rate; rats; reduction; renal; resistance; respiratory; response; results; right; risk; risk patients; samples; saps; score; sepsis; septic; serum; severe; severity; shock; shock patients; signs; specific; standard; status; stay; studies; study; study group; study period; subjects; support; surgery patients; surgical; survival; survivors; syndrome; system; systemic; technique; temperature; test; therapeutic; therapy; time; tissue; total; tracheal; transplantation; trauma patients; treatment; tube; type; unit; university; use; values; variables; vascular; vein; venous; ventilation; ventricular; volume; weaning; years cache: cord-005814-ak5pq312.txt plain text: cord-005814-ak5pq312.txt item: #41 of 227 id: cord-005875-yp1ehpeg author: Zhang, Dong title: Crocin alleviates lipopolysaccharide-induced acute respiratory distress syndrome by protecting against glycocalyx damage and suppressing inflammatory signaling pathways date: 2020-01-10 words: 5144 flesch: 42 summary: In pretreatment with crocin groups, SDC-4 and HS abscission were significantly decreased (Fig. 3a-d) . In the MMP-9 inhib + LPS group, HUVECs were pretreated with 5 µM concentration of MMP-9 inhibitor for 1 h before the LPS (1 µg/mL) stimulation for 6 h. In the CTL inhib + LPS group, HUVECs were pretreated with 10 µM concentration of CTL inhibitor for 1 h before the LPS (1 µg/mL) stimulation for 6 h. In the crocin + LPS group, HUVECs were pretreated with 20 µM concentration of crocin for 1 h before the LPS (1 µg/mL) stimulation for 6 h. Male mice (C57BL/6, 8-9 weeks old, weighing 18-20 g) were purchased from Jinan Animal Feed Center (Shandong, China). keywords: ards; crocin; ctl; endothelial; fig; glycocalyx; group; huvecs; lps; lung; mice cache: cord-005875-yp1ehpeg.txt plain text: cord-005875-yp1ehpeg.txt item: #42 of 227 id: cord-005910-byffqwjd author: Lewandowski, K. title: Der alte Mann und die „I sea U“: Essay über Vertrauen, Schicksal und Evidenz – im Stil von Hemingway date: 2016-12-06 words: 3374 flesch: 41 summary: Unter Insulintherapie soll die Überwachungsfrequenz in Abhängigkeit von der Dosis erhöht werden Being an essay on anemia, suffocation, starvation, and other forms of intensive care, after the manner of Dickens Being an essay on nonsense and common sense in the ICU, after the manner of Lewis Carroll Alice im Intensivland. Es wird infrage gestellt, ob der Plateaudruck der geeignete Parameter zur Festlegung der Beatmungsdrücke ist. keywords: aber; acute; als; ards; auf; bei; care; dass; delirium; den; der; des; die; distress; eine; für; ist; mit; nicht; patienten; patients; sich; syndrome; transfusion; und; ventilation; von; werden; wie cache: cord-005910-byffqwjd.txt plain text: cord-005910-byffqwjd.txt item: #43 of 227 id: cord-005941-e4fvj54l author: Hamm, H. title: The surfactant system of the adult lung: physiology and clinical perspectives date: 1992 words: 12905 flesch: 35 summary: Clq receptor binds other soluble proteins with collagen domains Specific interaction of lung surfactant protein A (SP-A) with rat alveolar macrophages Limitations of using urea to quantify epithelial lining fluid recovered by bronchalveolar lavage Surfactant in adult respiratory distress syndrome Surfactant apoprotein.-A concentration in sputum for diagnosis of pulmonary alveolar proteinosis Sublethal hyperoxic injury to the alveolar epithelium and the pulmonary surfactant system Characterization of antioxidant activities of pulmonary surfactant mixtures Idiopathic pulmonary fibrosis. The role of lung surfactant Role of pulmonary surfactant in the development and treatment of adult respiratory distress syndrome Effects of hemoglobin and cell membrane lipids on pulmonary surfactant activity Surface property changes from interactions of albumin with natural surfactant and extracted lung lipids Type II pneumocyte changes during hyperoxic lung injury and recovery Down-regulation of immune responses in the lower respiratory tract: the role of alveolar macrophages Changes in phospholipids in bronchoalveolar lavage fluid of patients with interstitial lung diseases Alterations of acidic phospholipids in bronchoalveolar lavage fluids of patients with pulmonary alveolar proteinosis Dissolution and reassembly of tubular myelin-like multilamellated structures from the lungs of patients with pulmonary alveolar proteinosis A multicenter, randomized, placebo-controlled trial of surfactant therapy for respiratory distress syndrome Surface and tissue forces, surfactant protein A, and the phospholipid components of pulmonary surfactant in bleomycin-induced pulmonary fibrosis in the rat Changes in phosphatidylglycerol in bronchoalveolar lavage fluids from patients with cryptogenic fibrosing alveolitis Changes of alveolar stability and phospholipids in pulmonary surfactant in acute pancreatitis Surfactant for the treatment of respiratory distress syndrome Surfactant protein B : disulfide bridges, structural properties, and kringle similarities Human alveolar lining material and antibacterial defenses Types of interaction of amphiphilic drugs with phospholipid vesicles Enhancement of bactericidal capacity of alveolar macrophages by human alveolar lining material Analysis of bronchoalveolar lavage and pulmonary alveolar surfactant for diagnosis of rejection and infection in heart-lung transplantation Alveolar type II cells, surfactant protein A (SP-A), and the phospholipid components of surfactant in acute silicosis in the rat Structure of alveolar epithelial cells in patients with fibrotic lung disorders Fluid dynamics during bronchoalveolar lavage Secretions from primary hamster tracheal surface epithelial cells in culture: mucin-like glycoproteins, proteoglycans, and lipids Isolation of apoproteins from canine surface active material -and pneumonia-induced lung injury. keywords: alveolar; alveolar type; bal; cells; changes; effects; lung; material; patients; phospholipids; protein; pulmonary; role; studies; surface; surfactant; synthesis; type; type ii cache: cord-005941-e4fvj54l.txt plain text: cord-005941-e4fvj54l.txt item: #44 of 227 id: cord-005985-csc3lfbm author: Seeger, W. title: Alveolar surfactant and adult respiratory distress syndrome: Pathogenetic role and therapeutic prospects date: 1993 words: 5564 flesch: 15 summary: Similarly, experimental approaches in adult animals with removal of alveolar surfactant (lung lavage models [97] ) and subsequent transbronchial readministration of surface active material have also underscored the fundamental significance of the alveolar surfactant system for ventilation-perfusion matching in adult lungs Alterations in alveolar surfactant function may well contribute to a variety of pathophysiological key events encountered in ARDS. keywords: alveolar; ards; fibrin; lung; patients; phospholipids; protein; pulmonary; surface; surfactant; syndrome cache: cord-005985-csc3lfbm.txt plain text: cord-005985-csc3lfbm.txt item: #45 of 227 id: cord-006181-fkh2fzbr author: Bednarczyk, Joseph M. title: Extracorporeal membrane oxygenation for blastomycosis-related acute respiratory distress syndrome: a case series date: 2015-04-08 words: 3536 flesch: 33 summary: Despite lung protective ventilation strategies with maximal F(i)O(2) (patients A-D), neuromuscular blockade (patients A-D), inhaled nitric oxide (patients A and D), and prone positioning (patient D), progressive hypoxemia resulted in initiation of venovenous ECMO by hours 24-90 of mechanical ventilation with subsequent de-escalation of ventilatory support. Life-threatening hypoxemia, acidosis, and injurious airway pressures developed despite 100% F I O 2 (patients A-D), neuromuscular blockade (patients A-D), inhaled nitric oxide at 20 ppm (patients A and D), and prone positioning (patient D) ( Table 2 ). keywords: ards; blastomycosis; ecmo; extracorporeal; lung; membrane; oxygenation; patients; support; ventilation cache: cord-006181-fkh2fzbr.txt plain text: cord-006181-fkh2fzbr.txt item: #46 of 227 id: cord-006237-oxbquzeg author: Dwenger, A. title: Bioluminescence, chemiluminescence date: 1990 words: 5003 flesch: 42 summary: At these times CL response was determined in whole blood and separated granulocytes from the portal vein (i. e. after passage through the pancreas) and the coeliac artery As appears from Fig. 1 , whole blood and especially separated granulocytes from the portal vein (to a much lower degree also from the coeliac artery) show a sharp increase in spontaneous The maximum is reached within 4 h after injection, with CL response being much higher in blood and granulocytes from the portal vein than in samples taken from the coeliac artery. keywords: alveolar; ards; blood; chemiluminescence; dna; granulocytes; macrophages; neutrophils; oxygen; patients; response; test cache: cord-006237-oxbquzeg.txt plain text: cord-006237-oxbquzeg.txt item: #47 of 227 id: cord-006251-danl62io author: Jansen, Oliver title: Extracorporeal membrane oxygenation in spina bifida and (H1N1)-induced acute respiratory distress syndrome date: 2017-09-13 words: 1700 flesch: 30 summary: Adding prone positioning therapy to ECMO patients is recommended by the guidelines for adult respiratory failure from the extracorporeal life support organization if radiological imaging shows posterior consolidation of the lung fields [8] . In the initial stage, moving the patients' body/body positioning therapy was conducted only to maintain or improve ECMO blood flow (see scheme above). keywords: ecmo; flow; patients; positioning; therapy cache: cord-006251-danl62io.txt plain text: cord-006251-danl62io.txt item: #48 of 227 id: cord-006366-qpjvmwmp author: Kinikar, Aarti Avinash title: Predictors of Mortality in Hospitalized Children with Pandemic H1N1 Influenza 2009 in Pune, India date: 2011-10-20 words: 3314 flesch: 39 summary: Of 775 pediatric cases admitted with Influenza Like Illness (ILI), 92 (11.8%) had confirmed H1N1 influenza infection. H1N1 infection caused significant pneumonia and ARDS, and resulted in ICU admissions and deaths in 96% and 16% of children, respectively. keywords: admission; children; h1n1; hospital; infection; influenza; mortality; pandemic cache: cord-006366-qpjvmwmp.txt plain text: cord-006366-qpjvmwmp.txt item: #49 of 227 id: cord-006459-9kizif98 author: Deng, Guangcun title: Acute respiratory distress syndrome induced by H9N2 virus in mice date: 2009-11-28 words: 3891 flesch: 49 summary: The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia Molecular characterization of H9N2 influenza viruses: were they the donors of the 'internal' genes of H5N1 viruses in Hong Kong? Characterization of the pathogenicity of members of the newly established H9N2 influenza virus lineages in Asia Infections and the inflammatory response in acute respiratory distress syndrome Sequence analysis of the hemagglutinin gene of H9N2 Korean avian influenza viruses and assessment of the pathogenic potential of isolate MS96 Evolution of H9N2 influenza viruses from domestic poultry in Mainland China Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates Respiratory reovirus 1/L induction of intraluminal fibrosis, a model of bronchiolitis obliterans organizing pneumonia, is dependent on T lymphocytes H9N2 influenza A viruses from poultry in Asia have human virus-like receptor specificity The comparative pathology of severe acute respiratory syndrome and avian influenza A subtype H5N1-a review Role of p38 mitogenactivated protein kinase in a murine model of pulmonary inflammation Cocirculation of avian H9N2 and contemporary 'human' H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment? Human infection with influenza H9N2 Prone position in acute respiratory distress syndrome Pulmonary and extrapulmonary acute respiratory distress syndrome are different Chemokines in acute respiratory distress syndrome Pigs are believed to serve as intermediate hosts for adaptation of avian influenza viruses that infect humans, and it has been shown that some of the H9N2 influenza viruses currently circulating in China have molecular features that allow them to preferentially bind to human a-2,6-NeuAcGal receptors [15, 24] . keywords: day; h9n2; infection; influenza; lung; mice; p.i; virus; viruses cache: cord-006459-9kizif98.txt plain text: cord-006459-9kizif98.txt item: #50 of 227 id: cord-006505-u3znxf2b author: Van Bever, H. P. title: Adult respiratory distress syndrome associated withMycoplasma pneumoniae infection date: 1992 words: 1533 flesch: 45 summary: Adult respiratory distress syndrome (ARDS) is a commonly recognized cause of acute respiratory failure in adults. M. pneumoniae has been implicated as a common cause of respiratory infections in childhood. keywords: ards; pneumoniae; syndrome cache: cord-006505-u3znxf2b.txt plain text: cord-006505-u3znxf2b.txt item: #51 of 227 id: cord-006565-5c14oqn4 author: Umans, U. title: Herpes simplex virus 1 pneumonia: conventional chest radiograph pattern date: 2001-02-24 words: 2788 flesch: 42 summary: (review) Medicine Necrotizing toxoplasmic encephalitis and herpetic pneumonia complicating treated Hodgkin's disease Herpes simplex virus pneumonia: occurrence in an allotransplanted lung Opportunistic bronchopulmonnary infections after lung transplantation: clinical and radiographic findings Nonbacterial pneumonia after allogenic marrow transplantion: review of 10 years experience Herpes simplex virus: the most frequently isolated pathogen in the lungs of patients with severe respiratory distress Herpes simplex viral pneumonia in the postthoracotomy patient Herpes simplex virus from the lower respiratory tract in adult respiratory distress syndrome Prevention of lower respiratory herpes simplex virus infection with acyclovir in patients with the adult respiratory distress syndrome Herpes simplex infection, an unusual source of adult respiratory distress syndrome Pulmonary herpes simplex in burns patients Herpes simplex virus 1 pneumonia: patterns on CT scans and conventional chest radiographs Neonatal herpes simplex pneumonia: radiographic findings Herpes simplex virus from respiratory tract secretions: epidemiology, clinical characteristics, and outcome in immunocompromised and nonimmunocompromised hosts Viral pneumonia after heart transplantation: a radioclinical study The American±European Consensus Conference on ARDS: definitions, mechanisms, relevant outcome, and clinical trial coordination The aim of this study was to describe the findings on plain chest radiographs in patients with herpes simplex virus pneumonia (HSVP). keywords: chest; herpes; patients; pneumonia; simplex cache: cord-006565-5c14oqn4.txt plain text: cord-006565-5c14oqn4.txt item: #52 of 227 id: cord-006700-df8ard9o author: Müller-Redetzky, Holger C. title: Dynamics of pulmonary endothelial barrier function in acute inflammation: mechanisms and therapeutic perspectives date: 2014-03-06 words: 10653 flesch: 18 summary: For example, cell wall peptidoglycan of Streptococcus pneumoniae activates TLR-2 (Schroder et al. 2003) , while the pneumococcal exotoxin pneumolysin is recognized by TLR-4 and NLRP-3 (Malley et al. 2003; Witzenrath et al. 2011) . Pneumolysin, for example, may rapidly induce (1) Ca 2+ influx and (2) liberation of platelet activating factor (PAF) followed by thromboxane release (Lucas et al. 2012; Witzenrath et al. 2007 ). keywords: activation; acute; barrier; cells; effects; endothelial; et al; fty720; function; inflammation; inflammatory; injury; kinase; lps; lung; mice; neutrophils; permeability; phosphate; protein; receptor; s1p; sepsis; sphingosine; vascular cache: cord-006700-df8ard9o.txt plain text: cord-006700-df8ard9o.txt item: #53 of 227 id: cord-006773-61ezrjuq author: Li, Hongqiang title: T follicular regulatory cells infiltrate the human airways during the onset of acute respiratory distress syndrome and regulate the development of B regulatory cells date: 2018-07-27 words: 4386 flesch: 58 summary: The frequency of non-Tfr Treg cells, calculated by the frequency of Treg cells minus the frequency of Tfr cells, was also slightly higher in ARDS patients than in healthy controls (P < 0.05). The frequencies of Treg cells, Tfr cells, and non-Tfr Treg cells in the PBMCs from ten healthy controls and ten ARDS patients. keywords: ards; cd4; cells; tfr; tfr cells; treg; treg cells cache: cord-006773-61ezrjuq.txt plain text: cord-006773-61ezrjuq.txt item: #54 of 227 id: cord-010443-4jblod8j author: Meduri, Gianfranco Umberto title: General Adaptation in Critical Illness: Glucocorticoid Receptor-alpha Master Regulator of Homeostatic Corrections date: 2020-04-22 words: 18853 flesch: 10 summary: Timeliness of corticosteroid use in icu patients with pneumonia and ards Efficacy of corticosteroids in acute respiratory distress syn-drome: an observational study early administration of hydrocortisone replacement after the advent of septic shock: impact on survival and immune response * Early initiation of low-dose corticosteroid therapy in the management of septic shock: a retrospective observational study Glucocorticoid treatment in community-acquired pneumonia Hydrocortisone plus fludrocortisone for adults with septic shock Immune effects of corticosteroids in sepsis Vasopressin deficiency contributes to the vasodilation of septic shock Circulating vasopressin levels in septic shock Dieter ayers for the, and I. Septic shock trial, interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock The Australian-New Zealand intensive care society clinical trials, adjunctive glucocorticoid therapy in patients with septic shock Successful treatment of acute lung injury with pitavastatin in septic mice: potential role of glucocorticoid receptor expression in alveolar macrophages Influence of drug treatment on glucocorticoid receptor levels in patients with coronary heart disease Mechanistic insights into the protective impact of zinc on sepsis The protection potential of antioxidant vitamins against acute respiratory distress syndrome: a rat trial An historical review of glucocorticoid treatment in sepsis. The role and effects of glucocorticoid-induced leucine zipper in the context of inflammation resolution Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes Glucocorticoid-mediated regulation of granulocyte apoptosis and macrophage phagocytosis of apoptotic cells: implications for the resolution of inflammation Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes Saturated-efferocytosis generates pro-resolving CD11blow macrophages: Modulation by resolvins and glucocorticoids Local amplification of glucocorticoids by 11 betahydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes Local amplification of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 and its role in the inflammatory response Glucocorticoids promote survival of anti-inflammatory macrophages via stimulation of adenosine receptor A3 Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide Ac(2-26) New lives given by cell death: macrophage differentiation following their encounter with apoptotic leukocytes during the resolution of inflammation Glucocorticoid resistance as a major drive in sepsis pathology Systemic inflammation-associated glucocorticoid resistance and outcome of ARDS Adrenal function and dysfunction in critically ill patients Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance Expression of the glucocorticoid receptor is decreased in experimental Staphylococcus aureus sepsis Cecal ligation and puncture alters glucocorticoid receptor expression Down regulation of hepatic glucocorticoid receptors after endotoxin treatment Nitric oxide up-regulates the glucocorticoid receptor and blunts the inflammatory reaction in porcine endotoxin sepsis Effects of different doses of hydrocortisone on acute lung injury in rats with early septic shock Glucocorticoid receptor expression on acute lung injury induced by endotoxin in rats Endothelial glucocorticoid receptor is required for protection against sepsis Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea pig lungs using methylprednisolone Low-dose dexamethasone alleviates lipopolysaccharide-induced acute lung injury in rats and upregulates pulmonary glucocorticoid receptors Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock Decreased cytosolic glucocorticoid receptor levels in critically ill patients Glucocorticoid receptor mRNA levels are selectively decreased in neutrophils of children with sepsis Reduced glucocorticoid receptor protein expression in children with critical illness Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-alpha Tissue mRNA expression of the glucocorticoid receptor and its splice variants in fatal critical illness An expanded definition of the adult respiratory distress syndrome Endothelial response to glucocorticoids in inflammatory diseases Dexamethasone potentiates in vitro blood-brain barrier recovery after primary blast injury by glucocorticoid receptor-mediated upregulation of ZO-1 tight junction protein Endothelial biomarkers in human sepsis: pathogenesis and prognosis for ARDS Dysregulation of the angiopoietin-Tie-2 axis in sepsis ARDS Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis Endothelial activation and blood-brain barrier injury as risk factors for Delirium in critically Ill patients Vitamin C revisited Microcirculatory alterations: potential mechanisms and implications for therapy. keywords: acid; activation; acute; ascorbic; cells; corrections; endothelial; expression; function; glucocorticoid; grα; human; illness; immune; inflammation; levels; mitochondria; mortality; nuclear; patients; receptor; response; role; sepsis; septic; shock; stress; tissue; transcription; treatment; vitamin cache: cord-010443-4jblod8j.txt plain text: cord-010443-4jblod8j.txt item: #55 of 227 id: cord-010509-gipjuhhc author: Xu, Jing title: Increased mortality of acute respiratory distress syndrome was associated with high levels of plasma phenylalanine date: 2020-04-30 words: 5992 flesch: 45 summary: Phenylalanine metabolism was the most notably altered pathway between the non-survivors and survivors of ARDS patients. Figure 4c shows that in both the ARDS versus healthy controls group and the non-survivors versus survivors group, Phenylalanine metabolism pathway, Phenylalanine, tyrosine and tryptophan biosynthesis pathway were identified as the most significantly altered pathways. keywords: analysis; ards; ards patients; controls; metabolites; mice; mortality; non; pathway; patients; phenylalanine; survivors cache: cord-010509-gipjuhhc.txt plain text: cord-010509-gipjuhhc.txt item: #56 of 227 id: cord-010550-lfbjvche author: Petran, Jan title: Validation of RESP and PRESERVE score for ARDS patients with pumpless extracorporeal lung assist (pECLA) date: 2020-05-02 words: 3765 flesch: 41 summary: In the PRESERVE and RESP score validation study most of the included patients suffered from severe hypoxemic ARDS Specific mortality risk scores, especially the Respiratory ECMO Survival Prediction (RESP) score keywords: ards; extracorporeal; patients; pecla; preserve; resp; score; study cache: cord-010550-lfbjvche.txt plain text: cord-010550-lfbjvche.txt item: #57 of 227 id: cord-011197-bmigh2rs author: Yener, Nazik title: Airway Pressure Release Ventilation as a Rescue Therapy in Pediatric Acute Respiratory Distress Syndrome date: 2020-03-03 words: 3496 flesch: 44 summary: Airway pressure release ventilation in children Airway pressure release ventilation in pediatric acute respiratory distress syndrome: a randomized controlled trial High frequency oscillation and airway pressure release ventilation in pediatric respiratory failure Airway pressure release ventilation Current role of high frequency oscillatory ventilation and airway pressure release ventilation in acute lung injury and acute respiratory distress syndrome Severe hypoxemic respiratory failure: part 1: ventilatory strategies Airway pressure release ventilation: what do we know? The study included patients aged between 1 mo and 18 y, receiving APRV ventilation during index admission to the PICU and who fulfilled the diagnostic criteria of ARDS, according to the PALLIC definition and were refractory to conventional low tidal volume ventilation. keywords: airway; aprv; ards; patients; pressure; study; ventilation cache: cord-011197-bmigh2rs.txt plain text: cord-011197-bmigh2rs.txt item: #58 of 227 id: cord-011286-8wxih7v6 author: You, Qinghai title: MiR-802 alleviates lipopolysaccharide-induced acute lung injury by targeting Peli2 date: 2019-11-06 words: 4631 flesch: 47 summary: Therefore, we concluded miR-802 expression may antagonize proinflammatory cytokine production during LPSmediated lung inflammatory response and tissue damage. However, miR-802 expression did not change the LPS effect on cell apoptosis. keywords: acute; ards; expression; fig; injury; lps; lung; macrophages; mir-802; mirna; model; peli2 cache: cord-011286-8wxih7v6.txt plain text: cord-011286-8wxih7v6.txt item: #59 of 227 id: cord-011363-o1f398vn author: Pitoni, Sara title: Tidal Volume Lowering by Instrumental Dead Space Reduction in Brain-Injured ARDS Patients: Effects on Respiratory Mechanics, Gas Exchange, and Cerebral Hemodynamics date: 2020-04-22 words: 4047 flesch: 41 summary: A retrospective analysis of patients with acute brain injury and acute respiratory failure Effects of PEEP on the intracranial system of patients with head injury and subarachnoid hemorrhage: the role of respiratory system compliance Association between ventilatory settings and development of acute respiratory distress syndrome in mechanically ventilated patients due to brain injury Tracheostomy procedures in the intensive care unit: an international survey Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries Lung volumes, respiratory mechanics and dynamic strain during general anaesthesia Should we use driving pressure to set tidal volume? Driving pressure and survival in the acute respiratory distress syndrome Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study Heat and moisture exchangers (HMEs) and heated humidifiers (HHs) in adult critically ill patients: a systematic review, meta-analysis and metaregression of randomized controlled trials Fifty years of research in ARDS. Effects on respiratory mechanics and gas exchange Acute respiratory distress syndrome: the Berlin definition Neuromuscular blockers in early acute respiratory distress syndrome Validation of Bohr dead space measured by volumetric capnography Volume capnography in the intensive care unit: physiological principles, measurements, and calculations Pressure-volume curves in acute respiratory failure: automated low flow inflation versus occlusion Pressure-volume curves and compliance in acute lung injury: evidence of recruitment above the lower inflection point A single computer-controlled mechanical insufflation allows determination of the pressure-volume relationship of the respiratory system Volumepressure curve of the respiratory system predicts effects of PEEP in ARDS: occlusion versus constant flow technique Heterogeneity of regional inflection points from pressurevolume curves assessed by electrical impedance tomography What has been learnt from P/V curves in patients with acute lung injury/acute respiratory distress syndrome Alveolar derecruitment at decremental positive end-expiratory pressure levels in acute lung injury: comparison with the lower inflection point, oxygenation, and compliance PEEP-induced changes in lung volume in acute respiratory distress syndrome. keywords: acute; brain; injury; lung; patients; pressure; study cache: cord-011363-o1f398vn.txt plain text: cord-011363-o1f398vn.txt item: #60 of 227 id: cord-011875-ga0dzj3v author: Tsolaki, Vasiliki title: Are Patients with COVID-19 Dying of or with Cardiac Injury? date: 2020-07-15 words: 1312 flesch: 38 summary: Basing respiratory management of COVID-19 on physiological principles Principles and practice of mechanical ventilation Philosophy of medicine: an introduction Use of high-flow nasal cannula oxygen therapy in subjects with ARDS: a 1-year observational study A multiple-center survey on the use in clinical practice of noninvasive ventilation as a first-line intervention for acute respiratory distress syndrome Consilience: the unity of knowledge Clinical features of 85 fatal cases of COVID-19 from Wuhan: a retrospective observational study Pathophysiology of Takotsubo syndrome Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirusinfected pneumonia in Wuhan, China New insights into the mechanisms involved in B-type natriuretic peptide elevation and its prognostic value in septic patients Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19) Very few reports have used echocardiographic criteria beyond biomarkers to diagnose cardiac injury, but none have differentiated between myocarditis, cardiomyopathy (stress or septic), ACS, and acute heart failure in the era of COVID-19. keywords: ards; covid-19; injury; patients cache: cord-011875-ga0dzj3v.txt plain text: cord-011875-ga0dzj3v.txt item: #61 of 227 id: cord-012010-5h2ox3hu author: Bos, Lieuwe D.J. title: Response to “COVID-19 conundrum: Clinical phenotyping based on pathophysiology as a promising approach to guide therapy in a novel illness” and “Strengthening the foundation of the house of CARDS by phenotyping on the fly” and “COVID-19 phenotypes: leading or misleading?” date: 2020-08-03 words: 2154 flesch: 31 summary: Further, a recent report from Haudebourg et al. demonstrated no correlation between duration of symptoms and respiratory compliance in COVID-19 patients ( Figure 1a ) We merely disagree with the correspondent's conclusions regarding the prevalence of these theoretical patients based on data from 16 patients [20] , as well as their subsequent recommendations to deviate from safe ventilatory practice for COVID-19 patients based on this limited data. keywords: ards; compliance; covid-19; data; patients cache: cord-012010-5h2ox3hu.txt plain text: cord-012010-5h2ox3hu.txt item: #62 of 227 id: cord-012045-1cqqj84n author: Li, Tiao title: The Role of Deubiquitinating Enzymes in Acute Lung Injury and Acute Respiratory Distress Syndrome date: 2020-07-08 words: 7511 flesch: 30 summary: Protein ubiquitination is reversible, the covalently attached monoubiquitin or polyubiquitin moieties within the targeted protein can be removed by a group of enzymes called deubiquitinating enzymes (DUBs). Signal transductions in control of protein stability and availability, including protein ubiquitination and degradation, are typical among the pathways. keywords: acute; ards; cells; cyld; deubiquitination; domain; dubs; enzymes; epithelial; infection; inflammation; lung; members; protein; responses; role; signaling; ubiquitin cache: cord-012045-1cqqj84n.txt plain text: cord-012045-1cqqj84n.txt item: #63 of 227 id: cord-012587-h3c9novk author: Bos, Lieuwe D. J. title: Subphenotyping Acute Respiratory Distress Syndrome in Patients with COVID-19: Consequences for Ventilator Management date: 2020-09-17 words: 1462 flesch: 44 summary: Patients with H-type ARDS may benefit from lower tidal volumes and higher positive end-expiratory pressure (PEEP), and patients with L-type ARDS may benefit from higher tidal volumes and lower PEEP (5) . Patients with a nonfocal lung morphology had more parenchymal involvement (P = 0.0065) but did not have lower Crs (P = 0.72) than patients with focal lung morphology. keywords: ards; covid-19; lung; patients cache: cord-012587-h3c9novk.txt plain text: cord-012587-h3c9novk.txt item: #64 of 227 id: cord-013306-35jiycem author: Tarazan, Nehal title: Neuromuscular blocking agents in acute respiratory distress syndrome: updated systematic review and meta-analysis of randomized trials date: 2020-10-23 words: 4742 flesch: 45 summary: The Cochrane Collaboration's tool for assessing risk of bias in randomised trials Meta-analysis in clinical trials Bias in meta-analysis detected by a simple, graphical test GRADE: an emerging consensus on rating quality of evidence and strength of recommendations Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndrome Neuromuscular blocking agents decrease inflammatory response in patients presenting with acute respiratory distress syndrome Clinical study of early use of neuromuscular blocking agents in patients with severe sepsis and acute respiratory distress syndrome Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome To retain spontaneous breathing or eliminate spontaneous breathing with neuromuscular blockers in acute respiratory distress syndrome patients? First, we were unable to assess for publication bias because of the limited number of included studies. keywords: certainty; infusion; mortality; nmba; sedation; studies cache: cord-013306-35jiycem.txt plain text: cord-013306-35jiycem.txt item: #65 of 227 id: cord-014464-m5n250r2 author: Sole-Violan, J title: Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date: 2013-03-19 words: 99097 flesch: 51 summary: The application of the endotoxin activity assay was useful for bedside monitoring of endotoxemia in ICU patients. The aim of this study is to describe the clinical and epidemiological profi le of ICU patients receiving tigecycline (TGC) and to evaluate the potential benefi ts of TGC higher doses. keywords: acute; admission; adult patients; age; aim; analysis; blood; brain; cardiac; care; care patients; cases; clinical; conclusion; confi; control; criteria; critical; data; days; defi; diff; dose; early; ect; eff; emergency; erence; erent; failure; fi rst; figure; function; group; guidelines; high; hospital; hospital mortality; hours; icu admission; icu mortality; icu patients; icu stay; icus; identifi; increase; infl; injury; intensive; introduction; length; levels; low; lung; management; mean; median; medical; methods; methods patients; minutes; months; mortality; n =; number; nurses; organ; outcome; p =; patients; period; post; pressure; protocol; rate; renal; response; results; risk; rst; score; sepsis; septic; severity; shock; shock patients; signifi; stay; studies; study; surgery; surgery patients; surgical; test; therapy; time; total; treatment; uid; use; ventilation; volume; years cache: cord-014464-m5n250r2.txt plain text: cord-014464-m5n250r2.txt item: #66 of 227 id: cord-014533-6qfecv5h author: Velasquez, T. title: ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016 date: 2016-09-29 words: 88447 flesch: 46 summary: key: cord-014533-6qfecv5h authors: Velasquez, T.; Mackey, G.; Lusk, J.; Kyle, U. G.; Fontenot, T.; Marshall, P.; Shekerdemian, L. S.; Coss-Bu, J. A.; Nishigaki, A.; Yatabe, T.; Tamura, T.; Yamashita, K.; Yokoyama, M.; Ruiz-Rodriguez, J. C.; Encina, B.; Belmonte, R.; Troncoso, I.; Tormos, P.; Riveiro, M.; Baena, J.; Sanchez, A.; Bañeras, J.; Cordón, J.; Duran, N.; Ruiz, A.; Caballero, J.; Nuvials, X.; Riera, J.; Serra, J.; Rutten, A. M. F.; van Ieperen, S. N. M.; Der Kinderen, E. P. H. M.; Van Logten, T.; Kovacikova, L.; Skrak, P.; Zahorec, M.; Kyle, U. G.; Akcan-Arikan, A.; Silva, J. C.; Mackey, G.; Lusk, J.; Goldsworthy, M.; Shekerdemian, L. S.; Coss-Bu, J. A.; Wood, D.; Harrison, D.; Parslow, R.; Davis, P.; Pappachan, J.; Goodwin, S.; Ramnarayan, P.; Chernyshuk, S.; Yemets, H.; Zhovnir, V.; Pulitano’, S. M.; De Rosa, S.; Mancino, A.; Villa, G.; Tosi, F.; Franchi, P.; Conti, G.; Patel, B.; Khine, H.; Shah, A.; Sung, D.; Singer, L.; Haghbin, S.; Inaloo, S.; Serati, Z.; Idei, M.; Nomura, T.; Yamamoto, N.; Sakai, Y.; Yoshida, T.; Matsuda, Y.; Yamaguchi, Y.; Takaki, S.; Yamaguchi, O.; Goto, T.; Longani, N.; Medar, S.; Abdel-Aal, I. R.; El Adawy, A. S.; Mohammed, H. M. E. H.; Mohamed, A. N.; Parry, S. M.; Knight, L. D.; Denehy, L.; De Morton, N.; Baldwin, C. E.; Sani, D.; Kayambu, G.; da Silva, V. Z. M.; Phongpagdi, P.; Puthucheary, Z. A.; Granger, C. L.; Rydingsward, J. E.; Horkan, C. M.; Christopher, K. B.; McWilliams, D.; Jones, C.; Reeves, E.; Atkins, G.; Snelson, C.; Aitken, L. M.; Rattray, J.; Kenardy, J.; Hull, A. M.; Ullman, A.; Le Brocque, R.; Mitchell, M.; Davis, C.; Macfarlane, B.; Azevedo, J. C.; Rocha, L. L.; De Freitas, F. F. M.; Cavalheiro, A. M.; Lucinio, N. M.; Lobato, M. S.; Ebeling, G.; Kraegpoeth, A.; Laerkner, E.; De Brito-Ashurst, I.; White, C.; Gregory, S.; Forni, L. G.; Flowers, E.; Curtis, A.; Wood, C. A.; Siu, K.; Venkatesan, K.; Muhammad, J. B. H.; Ng, L.; Seet, E.; Baptista, N.; Escoval, A.; Tomas, E.; Agrawal, R.; Mathew, R.; Varma, A.; Dima, E.; Charitidou, E.; Perivolioti, E.; Pratikaki, M.; Vrettou, C.; Giannopoulos, A.; Zakynthinos, S.; Routsi, C.; Atchade, E.; Houzé, S.; Jean-Baptiste, S.; Thabut, G.; Genève, C.; Tanaka, S.; Lortat-Jacob, B.; Augustin, P.; Desmard, M.; Montravers, P.; de Molina, F. J. González; Barbadillo, S.; Alejandro, R.; Álvarez-Lerma, F.; Vallés, J.; Catalán, R. M.; Palencia, E.; Jareño, A.; Granada, R. M.; Ignacio, M. L.; Cui, N.; Liu, D.; Wang, H.; Su, L.; Qiu, H.; Li, R.; Jaffal, K.; Rouzé, A.; Poissy, J.; Sendid, B.; Nseir, S.; Paramythiotou, E.; Rizos, M.; Frantzeskaki, F.; Antoniadou, A.; Vourli, S.; Zerva, L.; Armaganidis, A.; Riera, J.; Gottlieb, J.; Greer, M.; Wiesner, O.; Martínez, M.; Acuña, M.; Rello, J.; Welte, T.; Atchade, E.; Mignot, T.; Houzé, S.; Jean-Baptiste, S.; Thabut, G.; Lortat-Jacob, B.; Tanaka, S.; Augustin, P.; Desmard, M.; Montravers, P.; Soussi, S.; Dudoignon, E.; Ferry, A.; Chaussard, M.; Benyamina, M.; Alanio, A.; Touratier, S.; Chaouat, M.; Lafaurie, M.; Mimoun, M.; Mebazaa, A.; Legrand, M.; Sheils, M. A.; Patel, C.; Mohankumar, L.; Akhtar, N.; Noriega, S. K. Pacheco; Aldana, N. Navarrete; León, J. L. Ávila; Baquero, J. Durand; Bernal, F. Fernández; Ahmadnia, E.; Hadley, J. S.; Millar, M.; Hall, D.; Hewitt, H.; Yasuda, H.; Sanui, M.; Komuro, T.; Kawano, S.; Andoh, K.; Yamamoto, H.; Noda, E.; Hatakeyama, J.; Saitou, N.; Okamoto, H.; Kobayashi, A.; Takei, T.; Matsukubo, S.; Rotzel, H. B.; Lázaro, A. Serrano; Prada, D. Aguillón; Gimillo, M. Rodriguez; Barinas, O. Diaz; Cortes, M. L. Blasco; Franco, J. Ferreres; Roca, J. M. Segura; Carratalá, A.; Gonçalves, B.; Turon, R.; Mendes, A.; Miranda, F.; Mata, P. J.; Cavalcanti, D.; Melo, N.; Lacerda, P.; Kurtz, P.; Righy, C.; Rosario, L. E. de la Cruz; Lesmes, S. P. Gómez; Romero, J. C. García; Herrera, A. N. García; Pertuz, E. D. Díaz; Sánchez, M. J. Gómez; Sanz, E. Regidor; Hualde, J. Barado; Hernández, A. Ansotegui; Irazabal, J. M. Guergué; Spatenkova, V.; Bradac, O.; Suchomel, P.; Urli, T.; Lazzeri, E. Heusch; Aspide, R.; Zanello, M.; Perez-Borrero, L.; Garcia-Alvarez, J. M.; Arias-Verdu, M. D.; Aguilar-Alonso, E.; Rivera-Fernandez, R.; Mora-Ordoñez, J.; De La Fuente-Martos, C.; Castillo-Lorente, E.; Guerrero-Lopez, F.; Lesmes, S. P. Gómez; Rosario, L. E. De la Cruz; Pertuz, E. D. Díaz; Hernández, A. Ansotegui; Romero, J. C. García; Sánchez, M. J. Gómez; Herrera, A. N. García; Ramírez, J. Roldán; Sanz, E. Regidor; Hualde, J. Barado; León, J. P. Tirapu; Navarro-Guillamón, L.; Cordovilla-Guardia, S.; Iglesias-Santiago, A.; Guerrero-López, F.; Fernández-Mondéjar, E.; Vidal, A.; Perez, M.; Juez, A.; Arias, N.; Colino, L.; Perez, J. L.; Pérez, H.; Calpe, P.; Alcala, M. A.; Robaglia, D.; Perez, C.; Lan, S. K.; Cunha, M. M.; Moreira, T.; Santos, F.; Lafuente, E.; Fernandes, M. J.; Silva, J. G.; Rosario, L. E. de la Cruz; Lesmes, S. P. Gómez; Herrera, A. N. García; Romero, J. C. García; Pertuz, E. D. Díaz; Sánchez, M. J. Gómez; Sanz, E. Regidor; Echeverría, J. G. Armando; Hernández, A. Ansotegui; Hualde, J. Barado; Podlepich, V.; Sokolova, E.; Alexandrova, E.; Lapteva, K.; Kurtz, P.; Shuinotsuka, C.; Rabello, L.; Vianna, G.; Reis, A.; Cairus, C.; Salluh, J.; Bozza, F.; Torres, J. C. Barrios; Araujo, N. J. Fernández; García-Olivares, P.; Keough, E.; Dalorzo, M.; Tang, L. K.; De Sousa, I.; Díaz, M.; Marcos-Zambrano, L. J.; Guerrero, J. E.; Gomez, S. E. Zamora; Lopez, G. D. Hernandez; Cuellar, A. I. Vazquez; Nieto, O. R. Perez; Gonzalez, J. A. Castanon; Bhasin, D.; Rai, S.; Singh, H.; Gupta, O.; Bhattal, M. K.; Sampley, S.; Sekhri, K.; Nandha, R.; Aliaga, F. A.; Olivares, F.; Appiani, F.; Farias, P.; Alberto, F.; Hernández, A.; Pons, S.; Sonneville, R.; Bouadma, L.; Neuville, M.; Mariotte, E.; Radjou, A.; Lebut, J.; Chemam, S.; Voiriot, G.; Dilly, M. P.; Mourvillier, B.; Dorent, R.; Nataf, P.; Wolff, M.; Timsit, J. F.; Ediboglu, O.; Ataman, S.; Ozkarakas, H.; Kirakli, C.; Vakalos, A.; Avramidis, V.; Obukhova, O.; Kurmukov, I. A.; Kashiya, S.; Golovnya, E.; Baikova, V. N.; Ageeva, T.; Haritydi, T.; Kulaga, E. V.; Rios-Toro, J. J.; Perez-Borrero, L.; Aguilar-Alonso, E.; Arias-Verdu, M. D.; Garcia-Alvarez, J. M.; Lopez-Caler, C.; De La Fuente-Martos, C.; Rodriguez-Fernandez, S.; Sanchez-Orézzoli, M. Gomez; Martin-Gallardo, F.; Nikhilesh, J.; Joshi, V.; Villarreal, E.; Ruiz, J.; Gordon, M.; Quinza, A.; Gimenez, J.; Piñol, M.; Castellanos, A.; Ramirez, P.; Jeon, Y. D.; Jeong, W. Y.; Kim, M. H.; Jeong, I. Y.; Ahn, M. Y.; Ahn, J. Y.; Han, S. H.; Choi, J. Y.; Song, Y. G.; Kim, J. M.; Ku, N. S.; Shah, H.; Kellner, F.; Rezai, F.; Mistry, N.; Yodice, P.; Ovnanian, V.; Fless, K.; Handler, E.; Alejos, R. Martínez; Romeu, J. D. Martí; Antón, D. González; Quinart, A.; Martí, A. Torres; Llaurado-Serra, M.; Lobo-Civico, A.; Ventura-Rosado, A.; Piñol-Tena, A.; Pi-Guerrero, M.; Paños-Espinosa, C.; Peralvo-Bernat, M.; Marine-Vidal, J.; Gonzalez-Engroba, R.; Montesinos-Cerro, N.; Treso-Geira, M.; Valeiras-Valero, A.; Martinez-Reyes, L.; Sandiumenge, A.; Jimenez-Herrera, M. F.; Helyar, S.; Riozzi, P.; Noon, A.; Hallows, G.; Cotton, H.; Keep, J.; Hopkins, P. A.; Taggu, A.; Renuka, S.; Sampath, S.; Rood, P. J. T.; Frenzel, T.; Verhage, R.; Bonn, M.; Pickkers, P.; van der Hoeven, J. G.; van den Boogaard, M.; Corradi, F.; Melnyk, L.; Moggia, F.; Pienovi, R.; Adriano, G.; Brusasco, C.; Mariotti, L.; Lattuada, M.; Bloomer, M. J.; Coombs, M.; Ranse, K.; Endacott, R.; Maertens, B.; Blot, K.; Blot, S.; Amerongen, M. P. van Nieuw; van der Heiden, E. S.; Twisk, J. W. R.; Girbes, A. R. J.; Spijkstra, J. J.; Riozzi, P.; Helyar, S.; Cotton, H.; Hallows, G.; Noon, A.; Bell, C.; Peters, K.; Feehan, A.; Keep, J.; Hopkins, P. A.; Churchill, K.; Hawkins, K.; Brook, R.; Paver, N.; Endacott, R.; Maistry, N.; van Wijk, A.; Rouw, N.; van Galen, T.; Evelein-Brugman, S.; Taggu, A.; Krishna, B.; Sampath, S.; Putzu, A.; Fang, M.; Berto, M. Boscolo; Belletti, A.; Cassina, T.; Cabrini, L.; Mistry, M.; Alhamdi, Y.; Welters, I.; Abrams, S. T.; Toh, C. H.; Han, H. S.; Gil, E. M.; Lee, D. S.; Park, C. M.; Winder-Rhodes, S.; Lotay, R.; Doyle, J.; Ke, M. W.; Huang, W. C.; Chiang, C. H.; Hung, W. T.; Cheng, C. C.; Lin, K. C.; Lin, S. C.; Chiou, K. R.; Wann, S. R.; Shu, C. W.; Kang, P. L.; Mar, G. Y.; Liu, C. P.; Dubó, S.; Aquevedo, A.; Jibaja, M.; Berrutti, D.; Labra, C.; Lagos, R.; García, M. F.; Ramirez, V.; Tobar, M.; Picoita, F.; Peláez, C.; Carpio, D.; Alegría, L.; Hidalgo, C.; Godoy, K.; Bakker, J.; Hernández, G.; Sadamoto, Y.; Katabami, K.; Wada, T.; Ono, Y.; Maekawa, K.; Hayakawa, M.; Sawamura, A.; Gando, S.; Marin-Mateos, H.; Perez-Vela, J. L.; Garcia-Gigorro, R.; Peiretti, M. A. Corres; Lopez-Gude, M. J.; Chacon-Alves, S.; Renes-Carreño, E.; Montejo-González, J. C.; Parlevliet, K. L.; Touw, H. R. W.; Beerepoot, M.; Boer, C.; Elbers, P. W. G.; Tuinman, P. R.; Abdelmonem, S. A.; Helmy, T. A.; El Sayed, I.; Ghazal, S.; Akhlagh, S. H.; Masjedi, M.; Hozhabri, K.; Kamali, E.; Zýková, I.; Paldusová, B.; Sedlák, P.; Morman, D.; Youn, A. M.; Ohta, Y.; Sakuma, M.; Bates, D.; Morimoto, T.; Su, P. L.; Chang, W. Y.; Lin, W. C.; Chen, C. W.; Facchin, F.; Zarantonello, F.; Panciera, G.; De Cassai, A.; Venrdramin, A.; Ballin, A.; Tonetti, T.; Persona, P.; Ori, C.; Del Sorbo, L.; Rossi, S.; Vergani, G.; Cressoni, M.; Chiumello, D.; Chiurazzi, C.; Brioni, M.; Algieri, I.; Tonetti, T.; Guanziroli, M.; Colombo, A.; Tomic, I.; Colombo, A.; Crimella, F.; Carlesso, E.; Gasparovic, V.; Gattinoni, L.; Neto, A. Serpa; Schmidt, M.; Pham, T.; Combes, A.; de Abreu, M. Gama; Pelosi, P.; Schultz, M. J.; Katira, B. H.; Engelberts, D.; Giesinger, R. E.; Ackerley, C.; Yoshida, T.; Zabini, D.; Otulakowski, G.; Post, M.; Kuebler, W. M.; McNamara, P. J.; Kavanagh, B. P.; Pirracchio, R.; Rigon, M. Resche; Carone, M.; Chevret, S.; Annane, D.; Eladawy, S.; El-Hamamsy, M.; Bazan, N.; Elgendy, M.; De Pascale, G.; Vallecoccia, M. S.; Cutuli, S. L.; Di Gravio, V.; Pennisi, M. A.; Conti, G.; Antonelli, M.; Andreis, D. T.; Khaliq, W.; Singer, M.; Hartmann, J.; Harm, S.; Carmona, S. Alcantara; Almudevar, P. Matia; Abellán, A. Naharro; Ramos, J. Veganzones; Pérez, L. Pérez; Valbuena, B. Lobo; Sanz, N. Martínez; Simón, I. Fernández; Arrigo, M.; Feliot, E.; Deye, N.; Cariou, A.; Guidet, B.; Jaber, S.; Leone, M.; Resche-Rigon, M.; Baron, A. Vieillard; Legrand, M.; Gayat, E.; Mebazaa, A.; Balik, M.; Kolnikova, I.; Maly, M.; Waldauf, P.; Tavazzi, G.; Kristof, J.; Herpain, A.; Su, F.; Post, E.; Taccone, F.; Vincent, J. L.; Creteur, J.; Lee, C.; Hatib, F.; Jian, Z.; Buddi, S.; Cannesson, M.; Fileković, S.; Turel, M.; Knafelj, R.; Gorjup, V.; Stanić, R.; Gradišek, P.; Cerović, O.; Mirković, T.; Noč, M.; Tirkkonen, J.; Hellevuo, H.; Olkkola, K. T.; Hoppu, S.; Lin, K. C.; Hung, W. T.; Chiang, C. C.; Huang, W. C.; Juan, W. C.; Lin, S. C.; Cheng, C. C.; Lin, P. H.; Fong, K. Y.; Hou, D. S.; Kang, P. L.; Wann, S. R.; Chen, Y. S.; Mar, G. Y.; Liu, C. P.; Paul, M.; Bougouin, W.; Geri, G.; Dumas, F.; Champigneulle, B.; Legriel, S.; Charpentier, J.; Mira, J. P.; Sandroni, C.; Cariou, A.; Zimmerman, J.; Sullivan, E.; Noursadeghi, M.; Fox, B.; Sampson, D.; McHugh, L.; Yager, T.; Cermelli, S.; Seldon, T.; Bhide, S.; Brandon, R. A.; Brandon, R. B.; Zwaag, J.; Beunders, R.; Pickkers, P.; Kox, M.; Gul, F.; Arslantas, M. K.; Genc, D.; Zibandah, N.; Topcu, L.; Akkoc, T.; Cinel, I.; Greco, E.; Lauretta, M. P.; Andreis, D. T.; Singer, M.; Garcia, I. Palacios; Cordero, M.; Martin, A. Diaz; Pallás, T. Aldabó; Montero, J. Garnacho; Rey, J. Revuelto; Malo, L. Roman; Montoya, A. A. Tanaka; Martinez, A. D. C. Amador; Ayala, L. Y. Delgado; Zepeda, E. Monares; Granillo, J. Franco; Sanchez, J. Aguirre; Alejo, G. Camarena; Cabrera, A. Rugerio; Montenegro, A. Pedraza; Pham, T.; Beduneau, G.; Schortgen, F.; Piquilloud, L.; Zogheib, E.; Jonas, M.; Grelon, F.; Runge, I.; Terzi, N.; Grangé, S.; Barberet, G.; Guitard, P. G.; Frat, J. P.; Constan, A.; Chrétien, J. M.; Mancebo, J.; Mercat, A.; Richard, J. C. M.; Brochard, L.; Soilemezi, E.; Koco, E.; Savvidou, S.; Nouris, C.; Matamis, D.; Di Mussi, R.; Spadaro, S.; Volta, C. A.; Mariani, M.; Colaprico, A.; Antonio, C.; Bruno, F.; Grasso, S.; Rodriguez, A.; Martín-Loeches, I.; Díaz, E.; Masclans, J. R.; Gordo, F.; Solé-Violán, J.; Bodí, M.; Avilés-Jurado, F. X.; Trefler, S.; Magret, M.; Reyes, L. F.; Marín-Corral, J.; Yebenes, J. C.; Esteban, A.; Anzueto, A.; Aliberti, S.; Restrepo, M. I.; Larsson, J. Skytte; Redfors, B.; Ricksten, S. 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R.; Villarreal, E.; Gordon, M.; Sosa, M.; Concha, P.; Castellanos, A.; Menendez, R.; Ramírez, C. Sánchez; Santana, M. Cabrera; Balcázar, L. Caipe; Escalada, S. Hípola; Viera, M. A. Hernández; Vázquez, C. F. Lübbe; Díaz, J. J. Díaz; Campelo, F. Artiles; Monroy, N. Sangil; Santana, P. Saavedra; Santana, S. Ruiz; Gutiérrez-Pizarraya, A.; Garnacho-Montero, J.; Martin, C.; Baumstarck, K.; Leone, M.; Martín-Loeches, I.; Pirracchio, R.; Legrand, M.; Mainardi, J. L.; Mantz, J.; Cholley, B.; Hubbard, A.; Frontera, P. Ruiz; Vega, L. M. Claraco; Miguelena, P. Ruiz de Gopegui; Usón, M. C. Villuendas; López, A. Rezusta; Clemente, E. Aurensanz; Ibañes, P. Gutiérrez; Aguilar, A. L. Ruiz; Palomar, M.; Olaechea, P.; Uriona, S.; Vallverdu, M.; Catalan, M.; Nuvials, X.; Aragon, C.; Lerma, F. Alvarez; Jeon, Y. D.; Jeong, W. Y.; Kim, M. H.; Jeong, I. Y.; Ahn, M. Y.; Ahn, J. Y.; Han, S. H.; Choi, J. Y.; Song, Y. G.; Kim, J. M.; Ku, N. S.; Bassi, G. Li; Xiol, E. Aguilera; Senussi, T.; Idone, F. 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Alcántara; Castañeda, D. Palacios; Abellán, A. Naharro; Lucendo, A. Pérez; Pérez, L. Pérez; Rivas, R. Fernández; Sanz, N. Martínez; Ramos, J. Veganzones; Villamizar, P. Rodríguez; Javadpour, S.; Kalani, N.; Amininejad, T.; Jamali, S.; Sobhanian, S.; Laurent, A.; Bonnet, M.; Rigal, R.; Aslanian, P.; Hebert, P.; Capellier, G.; Contreras, M. R. Diaz; Mejías, C. Rodriguez; Ruiz, F. C. Santiago; Lombardo, M. Duro; Perez, J. Castaño; de Hoyos, E. Aguayo; Estella, A.; Viciana, R.; Fontaiña, L. Perez; Rico, T.; Madueño, V. Perez; Recuerda, M.; Fernández, L.; Sandiumenge, A.; Bonet, S.; Mazo, C.; Rubiera, M.; Ruiz-Rodríguez, J. C.; Gracia, R. M.; Espinel, E.; Pont, T.; Kotsopoulos, A.; Jansen, N.; Abdo, W. F.; Gopcevic, A.; Gavranovic, Z.; Vucic, M.; Glogoski, M. Zlatic; Penavic, L. Videc; Horvat, A.; Martin-Villen, L.; Egea-Guerero, J. J.; Revuelto-Rey, J.; Aldabo-Pallas, T.; Correa-Chamorro, E.; Gallego-Corpa, A. I.; Granados, P. Ruiz del Portal-Ruiz; Faivre, V.; Wildenberg, L.; Huot, B.; Lukaszewicz, A. C.; Simsir, M.; Mengelle, C.; Payen, D.; Sanz, N. Martinez; Valbuena, B. Lobo; de la Fuente, M. Valdivia; Almudena, P. Matía; Pérez, L. Pérez; Carmona, S. Alcántara; Abellán, A. Navarro; Simón, I. Fernández; Muñoz, J. J. Rubio; Ramos, J. Veganzones; Carmona, S. Alcantara; Almudevar, P. Matia; Abellan, A. Naharro; Lucendo, M. A. Perez; Perez, L. Perez; Dominguez, J. Palamidessi; Rivas, R. Fernandez; Villamizar, P. Rodriguez; Wee, S.; Ong, C.; Lau, Y. H.; Wong, Y.; Banderas-Bravo, M. E.; Olea-Jiménez, V.; Mora-Ordóñez, J. M.; Gómez-Jiménez, C.; Muñoz-Muñoz, J. L.; Vallejo-Báez, J.; Daga-Ruiz, D.; Lebrón-Gallardo, M.; Rialp, G.; Raurich, J. M.; Morán, I.; Martín, M. C.; Heras, G.; Mas, A.; Vallverdú, I.; Hraiech, S.; Bourenne, J.; Guervilly, C.; Forel, J. M.; Adda, M.; Sylla, P.; Mouaci, A.; Gainnier, M.; Papazian, L.; Bauer, P. R.; Kumbamu, A.; Wilson, M. E.; Pannu, J. K.; Egginton, J. S.; Kashyap, R.; Gajic, O.; Yoshihiro, S.; Sakuraya, M.; Hayakawa, M.; Hirata, A.; Kawamura, N.; Tsutui, T.; Yoshida, K.; Hashimoto, Y.; Chang, C. H.; Hu, H. C.; Chiu, L. C.; Hung, C. Y.; Li, S. H.; Kao, K. C.; Sibley, S.; Drover, J.; D’Arsigny, C.; Parker, C.; Howes, D.; Moffatt, S.; Erb, J.; Ilan, R.; Messenger, D.; Ball, I.; Boyd, J. G.; Harrison, M.; Ridi, S.; Muscedere, J.; Andrade, A. H.; Costa, R. C.; Souza, V. A.; Gonzalez, V.; Amorim, V.; Rolla, F.; Filho, C. A. C. Abreu; Miranda, R.; Atchasiri, S.; Buranavanich, P.; Wathanawatthu, T.; Suwanpasu, S.; Bureau, C.; Rolland-Debord, C.; Poitou, T.; Clavel, M.; Perbet, S.; Terzi, N.; Kouatchet, A.; Similowski, T.; Demoule, A.; Diaz, P.; Nunes, J.; Escórcio, S.; Silva, G.; Chaves, S.; Jardim, M.; Câmara, M.; Fernandes, N.; Duarte, R.; Jardim, J. J.; Pereira, C. A.; Nóbrega, J. J.; Chen, C. M.; Lai, C. C.; Cheng, K. C.; Chou, W.; Lee, S. J.; Cha, Y. S.; Lee, W. Y.; Onodera, M.; Nakataki, E.; Oto, J.; Imanaka, H.; Nishimura, M.; Khadjibaev, A.; Sabirov, D.; Rosstalnaya, A.; Akalaev, R.; Parpibaev, F.; Antonucci, E.; Rossini, P.; Gandolfi, S.; Montini, E.; Orlando, S.; van Nes, M.; Karachi, F.; Hanekom, S.; Andrade, A. H.; Pereira, U. V.; Filho, C. A. C. Abreu; Costa, R. C.; Parkin, M. S. W.; Moore, M.; Andrade, A. H.; Costa, R. C.; Carvalho, K. V. Silva; Filho, C. A. C. Abreu; Min, H. J.; Kim, H. J.; Lee, D. S.; Choi, Y. Y.; Lee, E. Y.; Song, I.; Kim, D. J.; E, Y. Y.; Kim, J. W.; Park, J. S.; Cho, Y. J.; Lee, J. H.; Suh, J. W.; Jo, Y. H.; Kim, K. S.; Lee, Y. J.; Ferrero-Calleja, J.; Merino-Vega, D.; González-Jiménez, A. I.; Sigcha, M. Sigcha; Hernández-Tejedor, A.; Martin-Vivas, A.; Gabán-Díez, Á.; Luna, R. Ruiz-de; De la Calle-Pedrosa, N.; Temprano-Gómez, I.; Afonso-Rivero, D.; Pellin-Ariño, J. I.; Algora-Weber, A.; Fumis, R. R. L.; Ferraz, A. B.; Junior, J. M. Vieira; Kirca, H.; Cakin, O.; Unal, M.; Mutlu, H.; Ramazanoglu, A.; Cengiz, M.; Nicolini, E. A.; Pelisson, F. G. F.; Nunes, R. S.; da Silva, S. L.; Carreira, M. M.; Bellissimo-Rodrigues, F.; Ferez, M. A.; Basile-Filho, A.; Chao, H. C.; Chen, C. M.; Chen, L.; Hravnak, M.; Clermont, G.; Pinsky, M.; Dubrawski, A.; Varas, J. Luján; Montero, R. Molina; Sánchez-Elvira, L. Alcázar; Díaz, P. Villa; Delgado, C. Pintado; Ruiz, B. Llorente; Guerrero, A. Pardo; Galache, J. A. Cambronero; Sherif, H.; Hassanin, H.; El Hossainy, R.; Samy, W.; Ly, H.; David, H.; Burtin, P.; Charpentier, C.; Barral, M.; Courant, P.; Fournel, E.; Gaide-Chevronnay, L.; Durand, M.; Albaladejo, P.; Payen, J. F.; Chavanon, O.; Ortiz, A. Blandino; Pozzebon, S.; Lheureux, O.; Brasseur, A.; Vincent, J. L.; Creteur, J.; Taccone, F. S.; Fumagalli, F.; Scala, S.; Affatato, R.; De Maglie, M.; Zani, D.; Novelli, D.; Marra, C.; Luciani, A.; De Zani, D.; Luini, M.; Letizia, T.; Pravettoni, D.; Staszewsky, L.; Masson, S.; Belloli, A.; Di Giancamillo, M.; Scanziani, E.; Latini, R.; Ristagno, G.; Kye, Y. C.; Suh, G. J.; Kwon, W. Y.; Kim, K. S.; Yu, K. M.; Babini, G.; Ristagno, G.; Grassi, L.; Fumagalli, F.; Bendel, S.; De Maglie, M.; Affatato, R.; Masson, S.; Latini, R.; Scanziani, E.; Reinikainen, M.; Skrifvars, M.; Kappler, F.; Blobner, M.; Schaller, S. J.; Roasio, A.; Costanzo, E.; Cardellino, S.; Iesu, E.; Cavicchi, F. Zama; Fontana, V.; Nobile, L.; Vincent, J. L.; Creteur, J.; Taccone, F. S.; Park, M.; You, K. M.; Suh, G. J.; Kwon, W. Y.; Ko, S. B.; Kim, K. S.; Xini, A.; Marca, L.; Lheureux, O.; Brasseur, A.; Vincent, J. L.; Creteur, J.; Taccone, F. S.; Beane, A.; Thilakasiri, M. C. K. T.; De Silva, A. P.; Stephens, T.; Sigera, C. S.; Athapattu, P.; Jayasinghe, S.; Padeniya, A.; Haniffa, R.; Santiago, A. Iglesias; Sáez, V. Chica; Ruiz-Ruano, R. de la Chica; González, A. Sánchez; Kunze-Szikszay, N.; Wand, S.; Klapsing, P.; Wetz, A.; Heyne, T.; Schwerdtfeger, K.; Troeltzsch, M.; Bauer, M.; Quintel, M.; Moerer, O.; Cook, D. J.; Rutherford, W. B.; Scales, D. C.; Adhikari, N. K.; Cuthbertson, B. H.; Suzuki, T.; Takei, T.; Fushimi, K.; Iwamoto, M.; Nakagawa, S.; Mendsaikhan, N.; Begzjav, T.; Lundeg, G.; Dünser, M. W.; Romero, D. González; Cabrera, J. L. Santana; Santana, J. D. Martín; Padilla, Y. Santana; Pérez, H. Rodríguez; Torrent, R. Lorenzo; Kleinpell, R.; Chouris, I.; Radu, V.; Stougianni, M.; Lavrentieva, A.; Lagonidis, D.; Price, R. D. T.; Day, A.; Arora, N.; Henderson, M. A.; Hickey, S.; Costa, M. I. Almeida; Carvalho, J. P.; Gomes, A. A.; Mergulhão, P. J.; Chan, K. K. C.; Shum, H. P.; Yan, W. W.; Maghsoudi, B.; Tabei, S. H.; Masjedi, M.; Sabetian, G.; Tabatabaei, H. R.; Akbarzadeh, A.; Saigal, S.; Pakhare, A.; Joshi, R.; Pattnaik, S. K.; Ray, B.; Rousseau, A. F.; Michel, L.; Bawin, M.; Cavalier, E.; Reginster, J. Y.; Damas, P.; Bruyere, O.; Zhou, J. C.; Cauwenberghs, H.; De Backer, A.; Neels, H.; Deblier, I.; Berghmans, J.; Himpe, D.; Barea-Mendoza, J. A.; Portillo, I. Prieto; Fernández, M. Valiente; Gigorro, R. Garcia; Vela, J. L. Perez; Mateos, H. Marín; Alves, S. Chacón; Varas, G. Morales; Rodriguez-Biendicho, A.; Carreño, E. Renes; González, J. C. Montejo; Yang, J. S.; Chiang, C. H.; Hung, W. T.; Huang, W. C.; Cheng, C. C.; Lin, K. C.; Lin, S. C.; Chiou, K. R.; Wann, S. R.; Lin, K. L.; Kang, P. L.; Mar, G. Y.; Liu, C. P.; Zhou, J. C.; Choi, Y. J.; Yoon, S. Z.; Gordillo-Brenes, A.; Fernandez-Zamora, M. D.; Perez-Borrero, L.; Arias-Verdu, M. D.; Aguilar-Alonso, E.; Herruzo-Aviles, A.; Garcia-Delgado, M.; Hinojosa-Perez, R.; Curiel-Balsera, E.; Rivera-Fernandez, R.; Lesmes, S. P. Gómez; Rosario, L. E. De la Cruz; Hernández, A. Ansotegui; Herrera, A. N. García; Sanz, E. Regidor; Sánchez, M. J. Gómez; Hualde, J. Barado; Pascual, O. Agudo; León, J. P. Tirapu; Irazabal, J. M. Guergue; Pérez, A. González; Fernández, P. Alvarez; Amor, L. Lopéz; Albaiceta, G. Muñiz; Lesmes, S. P. Gómez; Rosario, L. E. De la Cruz; Hernández, A. Ansotegui; Sanz, E. Regidor; Sánchez, M. J. Gómez; Calvo, S. Aldunate; Herrera, A. N. García; Hualde, J. Barado; Pascual, O. Agudo; León, J. P. Tirapu; Corona, A.; Ruffini, C.; Spazzadeschi, A.; Marrazzo, F.; Gandola, A.; Sciurti, R.; Savi, C.; Catena, E.; Ke, M. W.; Cheng, C. C.; Huang, W. C.; Chiang, C. H.; Hung, W. T.; Lin, K. C.; Lin, S. C.; Wann, S. R.; Chiou, K. R.; Tseng, C. J.; Kang, P. L.; Mar, G. Y.; Liu, C. P.; Bertini, P.; De Sanctis, F.; Guarracino, F.; Bertini, P.; Baldassarri, R.; Guarracino, F.; Buitinck, S. H.; van der Voort, P. H. J.; Oto, J.; Nakataki, E.; Tsunano, Y.; Izawa, M.; Tane, N.; Onodera, M.; Nishimura, M.; Ghosh, S.; Gupta, A.; De Gasperi, A.; Mazza, E.; Limuti, R.; Prosperi, M.; Bissenova, N.; Yergaliyeva, A.; Talan, L.; Yılmaz, G.; Güven, G.; Yoruk, F.; Altıntas, N. D.; Mukherjee, D. N.; Agarwal, L. K.; Mandal, K.; Palomar, M.; Balsera, B.; Vallverdu, M.; Martinez, M.; Garcia, M.; Castellana, D.; Lopez, R.; Barcenilla, F.; Kaminsky, G. E.; Carreño, R.; Escribá, A.; Fuentes, M.; Gálvez, V.; Del Olmo, R.; Nieto, B.; Vaquerizo, C.; Alvarez, J.; De la Torre, M. A.; Torres, E.; Bogossian, E.; Nouer, S. Aranha; Salgado, D. Ribeiro; Brugger, S. Carvalho; Jiménez, G. Jiménez; Torner, M. Miralbés; Vidal, M. Vallverdú; Garrido, B. Balsera; Casals, X. Nuvials; Gaite, F. Barcenilla; Cabello, J. Trujillano; Martínez, M. Palomar; Doganci, M.; Izdes, S.; Besevli, S. Guzeldag; Alkan, A.; Kayaaslan, B.; Ramírez, C. Sánchez; Balcázar, L. Caipe; Santana, M. Cabrera; Viera, M. A. Hernández; Escalada, S. Hípola; Vázquez, C. F. Lübbe; Penichet, S. M. Marrero; Campelo, F. Artiles; López, M. A. De La Cal; Santana, P. Saavedra; Santana, S. Ruíz; Repessé, X.; Artiguenave, M.; Paktoris-Papine, S.; Espinasse, F.; Dinh, A.; El Sayed, F.; Charron, C.; Géri, G.; Vieillard-Baron, A.; Marmanidou, K.; Oikonomou, M.; Nouris, C.; Dimitroulakis, K.; Soilemezi, E.; Matamis, D.; Ferré, A.; Guillot, M.; Teboul, J. L.; Lichtenstein, D.; Mézière, G.; Richard, C.; Monnet, X.; Pham, T.; Beduneau, G.; Schortgen, F.; Piquilloud, L.; Zogheib, E.; Jonas, M.; Grelon, F.; Runge, I.; Terzi, N.; Grangé, S.; Barberet, G.; Guitard, P. G.; Frat, J. P.; Constan, A.; Chrétien, J. M.; Mancebo, J.; Mercat, A.; Richard, J. C. M.; Brochard, L.; Prīdāne, S.; Sabeļņikovs, O.; Mojoli, F.; Orlando, A.; Bianchi, I.; Torriglia, F.; Bianzina, S.; Pozzi, M.; Iotti, G. A.; Braschi, A.; Beduneau, G.; Pham, T.; Schortgen, F.; Piquilloud, L.; Zogheib, E.; Jonas, M.; Grelon, F.; Runge, I.; Terzi, N.; Grangé, S.; Barberet, G.; Guitard, P. G.; Frat, J. P.; Constan, A.; Chrétien, J. M.; Mancebo, J.; Mercat, A.; Richard, J. C. M.; Brochard, L.; Kondili, E.; Psarologakis, C.; Kokkini, S.; Amargianitakis, V.; Babalis, D.; Chytas, A.; Chouvarda, I.; Vaporidi, K.; Georgopoulos, D.; Trapp, O.; Kalenka, A.; Mojoli, F.; Orlando, A.; Bianchi, I.; Torriglia, F.; Bianzina, S.; Pozzi, M.; Iotti, G. A.; Braschi, A.; Lozano, J. A. Benítez; Sánchez, P. Carmona; Francioni, J. E. Barrueco; Ferrón, F. Ruiz; Simón, J. M. Serrano; Spadaro, S.; Karbing, D. S.; Gioia, A.; Moro, F.; Corte, F. Dalla; Mauri, T.; Volta, C. A.; Rees, S. E.; Petrova, M. V.; Mohan, R.; Butrov, A. V.; Beeharry, S. D.; Vatsik, M. V.; Sakieva, F. I.; Gobert, F.; Yonis, H.; Tapponnier, R.; Fernandez, R.; Labaune, M. A.; Burle, J. F.; Barbier, J.; Vincent, B.; Cleyet, M.; Richard, J. C.; Guérin, C.; Shinotsuka, C. Righy; Creteur, J.; Taccone, F. S.; Törnblom, S.; Nisula, S.; Vaara, S.; Poukkanen, M.; Andersson, S.; Pettilä, V.; Pesonen, E.; Xie, Z.; Liao, X.; Kang, Y.; Zhang, J.; Kubota, K.; Egi, M.; Mizobuchi, S.; Hegazy, S.; El-Keraie, A.; El Sayed, E.; El Hamid, M. Abd; Rodrigues, N. J.; Pereira, M.; Godinho, I.; Gameiro, J.; Neves, M.; Gouveia, J.; e Silva, Z. Costa; Lopes, J. A.; Mckinlay, J.; Kostalas, M.; Kooner, G.; Dudas, G.; Horton, A.; Kerr, C.; Karanjia, N.; Creagh-Brown, B.; Forni, L.; Yamazaki, A.; Ganuza, M. Sanz; Molina, J. A. Martinez; Martinez, F. Hidalgo; Freile, M. T. Chiquito; Fernandez, N. Garcia; Travieso, P. Medrano; Bandert, A.; Frithiof, R.; Lipcsey, M.; Smekal, D.; Schlaepfer, P.; Durovray, J. D.; Plouhinec, V.; Chiappa, C.; Bellomo, R.; Schneider, A. G.; Mitchell, S.; Durrant, J.; Street, H.; Dunthorne, E.; Shears, J.; Caballero, C. Hernandez; Hutchison, R.; Schwarze, S.; Ghabina, S.; Thompson, E.; Prowle, J. R.; Kirwan, C. J.; Gonzalez, C. A.; Pinto, J. L.; Orozco, V.; Patiño, J. A.; Garcia, P. K.; Contreras, K. M.; Rodriguez, P.; Echeverri, J. E. title: ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016 date: 2016-09-29 journal: Intensive Care Med Exp DOI: 10.1186/s40635-016-0100-7 sha: doc_id: 14533 cord_uid: 6qfecv5h nan months is better than Cole's formula. keywords: acute; admission; adult patients; age; aki; analysis; ards patients; arrest; blood; c. a.; c. c.; c. m.; cardiac; care; care patients; care unit; cases; clinical; complications; conclusions; control; criteria; data; days; death; differences; discharge; duration; end; factors; failure; group; hospital; hospital mortality; hours; icu admission; icu mortality; icu patients; icu stay; impact; incidence; increased; infection; injury; intensive; introduction; j. a.; j. c.; j. e.; j. f.; j. g.; j. j.; j. l.; j. m.; j. p.; j. s.; length; level; lung; m. a.; m. d.; m. e.; m. m.; mean; median; medical; methods; mortality; non; number; objectives; organ; outcome; p =; patients; peep; period; post; pressure; quality; rate; results; resuscitation; risk; s. c.; s. m.; score; sepsis; septic; shock; standard; stay; study; surgery; surgical; survival; system; test; therapy; time; total; treatment; unit; use; value; ventilation; volume; weaning; y. j.; years cache: cord-014533-6qfecv5h.txt plain text: cord-014533-6qfecv5h.txt item: #67 of 227 id: cord-014538-6a2pviol author: Kamilia, Chtara title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 words: 61107 flesch: 45 summary: We included ICU patients admitted for acute hypoxemic respiratory failure from a previous prospective trial [1] in whom FiO 2 was measured under oxygen mask using a portable oxygen analyzer. Introduction Relative adrenal insufficiency (RAI) is common in ICU patients, particularly during septic shock (1). keywords: acute; admission; adult patients; age; aim; analysis; ards patients; arrest; blood; cardiac; care; care unit; cases; cause; children; clinical; conclusion; criteria; data; days; diagnosis; discussion; disease; duration; extubation; factors; failure; fluid; group; hospital; icu; icu admission; icu mortality; icu patients; incidence; infection; injury; intensive; introduction; jean; low; lung; management; mean; mechanical; median; medical; methods; mortality; n =; niv; non; nutrition; occurrence; outcome; oxygen; p =; patients; period; pierre; pneumonia; pressure; pulmonary; rate; renal; results; risk; score; sepsis; shock; shock patients; significant; stay; studies; study; study period; support; syndrome; therapy; time; treatment; unit; use; vap; ventilation; weaning; years cache: cord-014538-6a2pviol.txt plain text: cord-014538-6a2pviol.txt item: #68 of 227 id: cord-015021-pol2qm74 author: None title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 words: 162543 flesch: 45 summary: Ever since we know the role of endotoxins in the pathophysiology of sepsis, antibodies against the S-and R-LPS have also been detected in sepsis patients. In sepsis patients, the CD]4+/CD16+ cells can become a major population with more than 50% of all monocytes in 3 of 18 patients and with more than 500 cells/mm 3 in 4 of 18 cases. keywords: acid; activation; activity; acute; addition; adhesion; administration; aim; analysis; animals; anti; antibodies; antibody; ards; arterial; bacteria; binding; blood; blood cells; blood levels; blood samples; body; burn; capacity; cardiac; cause; cd14; cells; cellular; challenge; changes; circulating; clinical; clp; complement; complications; concentrations; conclusion; conditions; contrast; control; control group; control patients; correlation; course; csf; cultured; cytokine levels; cytokine production; cytokines; damage; data; days; death; decrease; development; differences; disease; dose; dysfunction; effect; elevated; elisa; endothelial; endotoxin; endotoxin levels; evidence; experimental; expression; factor; failure; flow; following; formation; function; gene; gram; group; growth; gut; hepatic; high; host; hours; hrs; human; il-1; il-6; il-6 levels; il-8; ill; immune; increased; induction; infection; inflammation; inflammatory; infusion; inhibitor; injury; ischemia; leukocytes; levels; lipid; liver; lps; lung; lymphocytes; macrophages; mean; mechanisms; mediators; membrane; methods; mice; model; mof; molecules; monoclonal; monocytes; mortality; multiple; necrosis; negative; neutrophils; new; non; normal; number; operation; organ; organ failure; organ injury; outcome; oxygen; p<0.05; parameters; patients; period; peritoneal; phase; placebo; plasma; plasma levels; plasma tnf; play; pmn; positive; post; postoperative; potential; presence; present; pressure; process; production; protein; pulmonary; rate; rats; receptor; reduced; related; release; reperfusion; response; results; risk; role; saline; samples; score; sepsis; sepsis patients; septic; serum; serum levels; severity; sham; shock; sirs; soluble; specific; state; stimulation; studies; study; surface; surgery; survival; syndrome; synthesis; system; systemic; t cells; test; therapeutic; therapy; time; tissue; tnf; tnf levels; tnf production; tnf release; total; trauma patients; treated; treatment; tumor; type; use; values; vascular; vitro; vivo; wound cache: cord-015021-pol2qm74.txt plain text: cord-015021-pol2qm74.txt item: #69 of 227 id: cord-015024-2xzc0uc5 author: None title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 words: 84465 flesch: 50 summary: The primary end point of this study was to evaluate the RVD of the IVC in ICU patients with spontaneous breathing. ICU patient with spontaneous breathing and signs of hypoperfusion (oliguria, mottles, serum lactate level [2 mmol/l) were eligible after the approval of the local Ethics Committee. keywords: acute; administration; admission; age; aim; analysis; apache; baseline; blood; cardiac; care; care patients; care unit; changes; clinical; conclusions; control; critical; data; day; days; death; difference; discharge; dose; effect; factors; failure; fluid; following; function; group; hemodynamic; high; hospital; icu admission; icu patients; incidence; increase; infusion; injury; intensive; introduction; levels; low; lung; management; mean; median; medical; methods; min; months; mortality; n =; non; number; nurses; objectives; outcome; p =; parameters; patients; period; plasma; post; pressure; pulmonary; rate; response; results; resuscitation; risk; score; sepsis; septic; serum; shock; shock patients; stay; study; support; surgery; test; therapy; time; total; treatment; unit; use; values; ventilation; volume; years cache: cord-015024-2xzc0uc5.txt plain text: cord-015024-2xzc0uc5.txt item: #70 of 227 id: cord-015126-cyhcbk1j author: None title: PS 0036-0344 date: 2007-08-25 words: 59258 flesch: 52 summary: The aim of this clinical trial is to study CIP in ICU patients (pts) after surgical procedures. The physiological condition of ICU patients is marked by rapidly evolving and frequently life-threatening derangements as well as 'silent' yet important alterations in homeostasis. keywords: acute; admission; age; aim; analysis; apache; arterial; baseline; blood; care; cases; changes; conclusion; control; data; days; disease; early; effects; end; factors; failure; fio2; flow; fluid; glucose; group; high; hospital; hours; icu; icu patients; increase; index; infection; infusion; injury; intensive; level; lung; mean; median; medical; min; model; mortality; non; outcome; parameters; patients; period; pressure; pts; rate; respiratory; results; risk; score; sepsis; septic; shock; shock patients; stay; study; support; surgery; system; test; therapy; time; total; trauma; treatment; unit; use; values; ventilation; volume; years cache: cord-015126-cyhcbk1j.txt plain text: cord-015126-cyhcbk1j.txt item: #71 of 227 id: cord-015384-bz7ui5a0 author: Hans-Peter, Kapfhammer title: Posttraumatic stress disorder in survivors of acute respiratory distress syndrome (ARDS) and septic shock date: 2008-11-27 words: 2531 flesch: 24 summary: Zum Zeitpunkt der Entlassung von der Intensivstation hatten 43,5% dieser Patienten das Vollbild einer PTSD, 8,9% wiesen eine sub-PTSD auf. Als Risikofaktoren für die Entwicklung eines PTSD konnten nicht die Schwere der somatischen Erkrankung (APA-CHE II Score, Lung Injury Score), aber die Anzahl der Tage der intensivmedizinischen keywords: acute; ali; ards; auf; care; der; die; disorder; distress; doses; einer; nach; patienten; ptsd; stress; survivors; syndrome; und; von cache: cord-015384-bz7ui5a0.txt plain text: cord-015384-bz7ui5a0.txt item: #72 of 227 id: cord-016142-7j5cdt1b author: Chiang, Eddie T. title: Acute Lung Injury: The Injured Lung Endothelium, Therapeutic Strategies for Barrier Protection, and Vascular Biomarkers date: 2010-06-28 words: 16122 flesch: 27 summary: [171] and to link S1P and its receptor ligation to enhanced vascular barrier regulation and demonstrated that physiological doses of S1P induce EC activation, marked cytoskeletal rearrangement, and stabilization of lung EC barrier function in vitro Finally, focal adhesions are intimately involved in lung EC barrier regulation via signaling between the cytoskeleton to the ECM. keywords: actin; activation; acute; ali; barrier; cadherin; cell; ecs; endothelial; function; inflammation; injury; kinase; levels; lung; lung injury; patients; pbef; permeability; phosphorylation; protein; pulmonary; receptor; regulation; role; s1p; sepsis; vascular cache: cord-016142-7j5cdt1b.txt plain text: cord-016142-7j5cdt1b.txt item: #73 of 227 id: cord-017126-7ebo3cy3 author: None title: Lungenversagen date: 2007 words: 4328 flesch: 25 summary: Die Hochfrequenzoszillation unterscheidet sich von der Hochfrequenz-Jet-Ventilation, dass sowohl neben der Inspiration auch die Exspiration aktiv ist, die Tidalvolumina kleiner sind als bei einer combined HFJV (meist unter 150 ml), der möglich anwendbare Frequenzbereich erstreckt Es kommt zunächst einerseits zu einer Erhöhung der Permeabilität der Gefäßwand mit interstitieller Ödembildung und anderseits zu einer Permeabilitätsstörung der Alveolarwand, hervorgerufen durch Membranfragmentationen der Endothelzellen und eine Degeneration der alveolären Epithelzellen (Typ-I-Pneumozyten) mit Ablösung von der Basalmembran. keywords: acute; als; alveolar; anwendung; ards; auch; bei; dass; den; der; des; die; distress; durch; eine; et al; frequency; injury; jet; kommt; lung; mit; patients; peep; respiratory; sich; sind; syndrome; und; ventilation; von; werden; wird cache: cord-017126-7ebo3cy3.txt plain text: cord-017126-7ebo3cy3.txt item: #74 of 227 id: cord-017853-mgsuwft0 author: Machado, Roberto F. title: Genomics of Acute Lung Injury and Vascular Barrier Dysfunction date: 2010-06-28 words: 9206 flesch: 26 summary: This approach identified multiple genes already recognized as ALI genes (such as IL-6, AQP-1, and PAI-1), but also identified several novel genes that were not previously known to be mechanistically involved in ALI [38] . Together, these approaches identified novel ALI genes such as PBEF, chemokine receptor (CXCR-4) GADD45. keywords: acute; ali; association; barrier; candidate; cell; endothelial; expression; factor; gene; growth; injury; levels; lung; novel; patients; pbef; role; sepsis; susceptibility; vascular cache: cord-017853-mgsuwft0.txt plain text: cord-017853-mgsuwft0.txt item: #75 of 227 id: cord-017854-ff3gm50j author: Bromberg, Z. title: Heat Shock Proteins in Inflammation date: 2007 words: 2413 flesch: 40 summary: Effects of heat on animals and man Heat shock proteins: facts, thoughts and dreams Heat shock proteins and cardiovascular pathophysiology Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology Protein translocation: how Hsp70 pulls it off Heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance Folding of newly translated proteins in vivo: the role of molecular chaperones Molecular chaperones in the cytosol: from nascent chain to folded protein Quality control of protein folding in extracellular space Specificity in intracellular protein aggregation and inclusion body formation Molecular chaperones: Cellular fold-controlling factors of toxic protein aggregates in neurodegenerative diseases Molecular chaperones in cellular protein folding The Hsp70 and Hsp60 chaperone machines Hsp90 and the chaperoning of cancer Hsp70 and Hsp90-a relay team for protein folding Heat shock response modulators as therapeutic tools for diseases of protein conformation Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury Structure-function analysis of HscC, the Escherichia coli member of a novel subfamily of specialized Hsp70 chaperones Intrahepatic STAT-3 activation and acute phase gene expression predict outcome after CLP sepsis in the rat Sepsis-induced alterations in phosphoenolpyruvate carboxykinase expression: the role of insulin and glucagon Sepsis-induced depression of rat glucose-6-phosphatase gene expression and activity Complexity of inflammatory mediators in acute respiratory distress syndrome (ARDS) Alterations of the endogenous surfactant system in septic adult rats Endotoxin inhibits heat induced Hsp70 in rats The chaperone function of hsp70 is required for protection against stress-induced apoptosis Major stress protein Hsp70 interacts with NF-κB regulatory complex in human T-lymphoma cells Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice Neutrophils induce apoptosis of lung epithelial cells via release of soluble Fas ligand Soluble Fas ligand induces epithelial cell apoptosis in humans with acute lung injury (ARDS) The proteasome: structure, function, and role in the cell Anti-inflammatory effect of heat shock protein induction is related to stabilization of I kappa B alpha through preventing I kappa B kinase activation in respiratory epithelial cells Heat shock inhibits radiation-induced activation of NF-kappaB via inhibition of I-kappaB kinase Ablation of the heat shock factor-1 increases susceptibility to hyperoxia-mediated cellular injury Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling HSP-70 Expression in the lung attenuates ARDS by disrupting NF-κB Acknowledgement. keywords: heat; hsp70; lung; protein; shock cache: cord-017854-ff3gm50j.txt plain text: cord-017854-ff3gm50j.txt item: #76 of 227 id: cord-017897-mbwm0ytg author: Chiumello, Davide title: The Acute Respiratory Distress Syndrome: Diagnosis and Management date: 2018-10-01 words: 4827 flesch: 28 summary: Compressive forces and computed tomography-derived positive end-expiratory pressure in acute respiratory distress syndrome Recruitment maneuvers in acute respiratory distress syndrome and during general anesthesia Effects of alveolar recruitment maneuvers on clinical outcomes in patients with acute respiratory distress syndrome: a systematic review and meta-analysis Bedside ultrasound assessment of positive end-expiratory pressure-induced lung recruitment Lung stress and strain during mechanical ventilation: any safe threshold? Low-dose chest computed tomography for quantitative and visual anatomical analysis in patients with acute respiratory distress syndrome Stress and strain within the lung The assessment of transpulmonary pressure in mechanically ventilated ARDS patients Lung protective ventilation strategy for the acute respiratory distress syndrome Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome Driving pressure and survival in the acute respiratory distress syndrome Balancing neuromuscular blockade versus preserved muscle activity Low mortality rate in adult respiratory distress syndrome using low-volume, pressure-limited ventilation with permissive hypercapnia: a prospective study Driving pressure and intraoperative protective ventilation Neuromuscular blocking agents in patients with acute respiratory distress syndrome: a summary of the current evidence from three randomized controlled trials The prone position in ARDS patients Use of extreme position changes in acute respiratory failure Prone position in acute respiratory distress syndrome. In respiratory failure patients, lung ultrasound is characterized mainly by B-line (hyperechogenic vertical artifact line that starts from pleura) keywords: acute; ards; distress; failure; lung; patients; pressure; syndrome; ventilation cache: cord-017897-mbwm0ytg.txt plain text: cord-017897-mbwm0ytg.txt item: #77 of 227 id: cord-018685-i7s04fh5 author: Bromberg, Z. title: Cell Regeneration in Lung Injury date: 2007 words: 3739 flesch: 39 summary: This included diffuse alveolar damage, desquamated epithelial cells, ATII hyperplasia, fibrin and collagen deposition in the alveolar spaces, and a loss of the normal barrier crucial for gas exchange [5, 10 -13] Cell regeneration is a fundamental biological response to cell damage. q -catenin has been shown to participate in signal transduction in epithelial cells. keywords: alveolar; ards; atii; cells; injury; lung; phase; stem cache: cord-018685-i7s04fh5.txt plain text: cord-018685-i7s04fh5.txt item: #78 of 227 id: cord-019010-9xgwjvsv author: Luna, C. M. title: Life-threatening Respiratory Failure from H1N1 Influenza: Lessons from the Southern Cone Outbreak date: 2010-06-23 words: 4579 flesch: 30 summary: It remains unknown whether these cases were secondary to some of the several risk factors that these bed-ridden severely ill patients had, or whether it was a direct consequence of a particular risk in influenza patients. Renal failure has been described in a number of influenza patients [7, 31] . keywords: ards; h1n1; infection; influenza; pandemic; patients; peep; pneumonia; pressure; ventilation; virus cache: cord-019010-9xgwjvsv.txt plain text: cord-019010-9xgwjvsv.txt item: #79 of 227 id: cord-020490-sjz5mbbr author: Mahida, R. Y. title: Extracellular Vesicles in ARDS: New Insights into Pathogenesis with Novel Clinical Applications date: 2019-11-30 words: 4794 flesch: 14 summary: Mesenchymal stromal cell extracellular vesicles can transfer mitochondria to alveolar macrophages, inducing a modified M2 (pro-resolving) phenotype [36] . Mesenchymal stromal cell extracellular vesicles modulate alveolar macrophages to clear bacteria more effectively, while minimizing surrounding tissue injury. keywords: ards; cells; endothelial; extracellular; injury; lung; release; vesicles cache: cord-020490-sjz5mbbr.txt plain text: cord-020490-sjz5mbbr.txt item: #80 of 227 id: cord-023890-z346hh2c author: Cotogni, Paolo title: Polyunsaturated Fatty Acids and Cytokines: Their Relationship in Acute Lung Injury date: 2015 words: 6965 flesch: 33 summary: Persistently high levels of pro-inflammatory cytokines, as well as a reduced production of anti-inflammatory cytokines, have been demonstrated to be correlated with the severity of lung injury. (e) A decreased production of pro-inflammatory cytokines, due to decreased activation of pro-inflammatory transcription factors such as nuclear factor κ-B and increased activation of anti-inflammatory transcription factors such as peroxisome proliferator-activated receptor-γ. keywords: acute; ali; alveolar; ards; cells; inflammatory; lung; n-3; n-6; oil; patients; pufas cache: cord-023890-z346hh2c.txt plain text: cord-023890-z346hh2c.txt item: #81 of 227 id: cord-025163-iyh0d6mj author: Ding, Lin title: Early diagnosis and appropriate respiratory support for Mycoplasma pneumoniae pneumonia associated acute respiratory distress syndrome in young and adult patients: a case series from two centers date: 2020-05-24 words: 4547 flesch: 40 summary: In one retrospective study from our hospital, 4.1% of M. pneumoniae pneumonia patients needed ICU admission for acute respiratory failure in the setting of an epidemic [21] . The rates of intensive care unit (ICU) admission of hospitalized M. pneumoniae pneumonia patients are reported as 10% in the US and 16.3% in Europe keywords: ards; cases; diagnosis; mycoplasma; patients; pneumoniae; study cache: cord-025163-iyh0d6mj.txt plain text: cord-025163-iyh0d6mj.txt item: #82 of 227 id: cord-025865-jjjr3ymt author: Eastin, Carly title: Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China: Wu C, Chen X, Cai Y, et al. JAMA Intern Med. doi:10.1001/jamainternmed.2020.0994. date: 2020-06-03 words: 1032 flesch: 56 summary: [13-23]), had lower temperatures (difference in proportion of high fever -31.8%, [-56.5% to -7.1%]), and received antivirals less often (difference -40.7%, 95% CI keywords: ards; patients cache: cord-025865-jjjr3ymt.txt plain text: cord-025865-jjjr3ymt.txt item: #83 of 227 id: cord-025920-9p5x26ge author: Qadir, Nida title: Adjunctive Therapies in ARDS: The Disconnect Between Clinical Trials and Clinical Practice date: 2020-06-03 words: 1215 flesch: 32 summary: Although the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG-SAFE) previously assessed the frequency of adjunctive therapy use all patients with ARDS, 3 a closer look at patients with a PaO 2 /FIO 2 ratio <150 is needed, as it is primarily this subset of patients in whom adjunctive therapies are recommended. Although the patient-level characteristics associated with adjunctive therapy use (younger age, more severe hypoxia, and hypercapnia) are unsurprising, other elements associated with adjunctive therapy use are thought-provoking and warrant more in-depth investigation. keywords: ards; patients; use cache: cord-025920-9p5x26ge.txt plain text: cord-025920-9p5x26ge.txt item: #84 of 227 id: cord-028337-md9om47x author: Ketcham, Scott W. title: Causes and characteristics of death in patients with acute hypoxemic respiratory failure and acute respiratory distress syndrome: a retrospective cohort study date: 2020-07-03 words: 4755 flesch: 42 summary: We sought to determine the causes and circumstances of death in a contemporary cohort of AHRF patients, and assess whether causes of death differed among patients with and without ARDS. Despite increased attention to earlier identification and treatment of sepsis in the intervening decades [17, 18] , our study found that sepsis remained the most common cause of death in AHRF patients. keywords: ahrf; ards; death; dysfunction; organ; patients; sepsis; support cache: cord-028337-md9om47x.txt plain text: cord-028337-md9om47x.txt item: #85 of 227 id: cord-028835-jby1btv7 author: Rilinger, Jonathan title: Prone positioning in severe ARDS requiring extracorporeal membrane oxygenation date: 2020-07-08 words: 3905 flesch: 49 summary: Sedation for PP patients at our institution was titrated to preserve spontaneous breathing if possible. However, it seems reasonable that PP patients might have been on deeper sedation levels than patients in the supine group. keywords: ards; ecmo; patients; support; survival; vs. cache: cord-028835-jby1btv7.txt plain text: cord-028835-jby1btv7.txt item: #86 of 227 id: cord-029646-oujgcciq author: Gupta, Ena title: Don’t Drive Blind: Driving Pressure to Optimize Ventilator Management in ECMO date: 2020-07-23 words: 3550 flesch: 51 summary: There are no studies evaluating role of driving pressure in this subset of ECMO patients. Data were collected retrospectively on baseline characteristics, comorbidities, ARDS status, severity of illness score like APACHE II score among all included ECMO patients. keywords: ards; driving; ecmo; patients; pressure cache: cord-029646-oujgcciq.txt plain text: cord-029646-oujgcciq.txt item: #87 of 227 id: cord-031033-v4yetn4f author: Martin-Loeches, Ignacio title: The importance of airway and lung microbiome in the critically ill date: 2020-08-31 words: 5112 flesch: 20 summary: This link needs to be further explored before we can conclude that lung microbiome dysbiosis is a potential target for treatment (Fig. 1) . To date, more than 30 studies have used sensitive, culture-independent techniques to study lung bacteria in healthy volunteers, and none has failed to detect a distinct bacterial signal [21] . keywords: ards; bacteria; gut; host; lung; lung microbiome; microbial; microbiome; patients; pneumonia; study cache: cord-031033-v4yetn4f.txt plain text: cord-031033-v4yetn4f.txt item: #88 of 227 id: cord-032608-zw540s64 author: Elsayed, Hany Hasan title: Dexamethasone for treatment of severe COVID-19, a surprise? date: 2020-09-24 words: 961 flesch: 42 summary: [2] suggested that a subset of COVID-19 pneumonia patients have preserved lung compliance and present with silent hypoxaemia. key: cord-032608-zw540s64 authors: Elsayed, Hany Hasan title: Dexamethasone for treatment of severe COVID-19, a surprise? date: 2020-09-24 journal: Cardiothorac Surg DOI: 10.1186/s43057-020-00032-1 sha: doc_id: 32608 cord_uid: zw540s64 nan The inclination that we lack all the knowledge needed to treat COVID-19 related ARDS may be dangerous in depriving COVID-19 patients from evidence-based medication. keywords: ards; covid-19; patients cache: cord-032608-zw540s64.txt plain text: cord-032608-zw540s64.txt item: #89 of 227 id: cord-033298-4d40yyzu author: Fiedler, M. O. title: Fokus Beatmung, Sauerstofftherapie und Weaning: Intensivmedizinische Studien aus 2019/2020 date: 2020-10-07 words: 3510 flesch: 38 summary: Die Herausforderung dabei besteht nicht nur in der lungenprotektiven Therapie, um einen VILI zu verhindern, sondern auch in der Entwöhnung der Beatmungstherapie und schlussendlich der erfolgreichen Extubation (Weaning). Jedoch auch diese bergen die Gefahr der Überdehnung oder der Atelektraumen bei unsachgemäßer Anwendung. keywords: ards; auf; beatmung; bei; das; der; des; die; distress; eine; ist; mit; nicht; patienten; patients; peep; pressure; respiratory; studie; syndrome; und; ventilation; von; werden; während cache: cord-033298-4d40yyzu.txt plain text: cord-033298-4d40yyzu.txt item: #90 of 227 id: cord-034469-ew90eef4 author: Dos Santos Rocha, Andre title: Physiologically variable ventilation reduces regional lung inflammation in a pediatric model of acute respiratory distress syndrome date: 2020-10-31 words: 4858 flesch: 35 summary: Subsequently, animals were randomized for the absence (CTRL) or presence (ARDS) of lung injury. Changes in respiratory mechanical parameters relative to those obtained immediately after the induction of lung injury are displayed in Fig. 2 . keywords: ards; inflammation; injury; lung; parameters; pressure; pvv; tissue; variable; ventilation; zones cache: cord-034469-ew90eef4.txt plain text: cord-034469-ew90eef4.txt item: #91 of 227 id: cord-035326-qjp37j7x author: Sryma, P.B. title: Reinventing the Wheel in ARDS: Awake Proning in COVID-19 date: 2020-11-11 words: 2394 flesch: 43 summary: Prone positioning in non-intubated patients is a newer concept that, if successful, may have far reaching impact in this time of COVID-19 pandemic. In case of any respiratory distress ROX index of ≤2.85 at 2 h, and ≤3.47 at 6 h may suggest poor response and should prompt escalation of care In case of sustained improvement in saturation to more than 93% in room air after 2 h of stopping prone positioning pattern may suggest an added advantage of PP in COVID-19 ARDS patients. keywords: ards; covid-19; oxygen; patients; positioning cache: cord-035326-qjp37j7x.txt plain text: cord-035326-qjp37j7x.txt item: #92 of 227 id: cord-102679-6dpo073b author: TRONCHE, P.-A. title: Assessment of a Novel Method for Non-invasive Sampling of the Distal Airspace in Acute Respiratory Distress Syndrome Patients Receiving Inhaled Sedation with Sevoflurane: the ANAISS Study Protocol date: 2020-10-07 words: 5176 flesch: 33 summary: A 4 mL blood sample will be simultaneously collected from an indwelling catheter (routinely used in ICU patients) into an EDTA tube, centrifuged at 2,000 × g for 10 min, and the supernatant (plasma) aliquoted and stored into a cryotube at -80°C. This duration was estimated based on a high incidence of ARDS in the ICU setting (10% of ICU admissions, and nearly 25% of ICU patients requiring mechanical ventilation, in a large recent observational study) (43) and available data from each participating centre that indicate the study is highly feasible (each of the two centres will need to include less than one patient per month, holidays excluded). keywords: acute; anaconda; ards; distress; fluid; license; medrxiv; patients; preprint; study; syndrome cache: cord-102679-6dpo073b.txt plain text: cord-102679-6dpo073b.txt item: #93 of 227 id: cord-104423-fxo36z1s author: Ghelichkhani, Parisa title: Prone Position in Management of COVID-19 Patients; a Commentary date: 2020-04-11 words: 1240 flesch: 40 summary: Available meta-analyses show that prone position can decrease mortality in ARDS patients when performed in the initial hours of disease manifestation, in patients with severe impaired oxygenation and for a long time (8) . Patients remaining in lengthy prone position sessions leads to decrease in mortality of patients (6) . keywords: ards; patients; position; treatment cache: cord-104423-fxo36z1s.txt plain text: cord-104423-fxo36z1s.txt item: #94 of 227 id: cord-252085-8dq3gdo8 author: Kaisy, Dr. Maythem Abdulhassan Al title: Chest Drain Insertion following Pneumothorax due to CPR in a COVID – 19 Patient. date: 2020-08-14 words: 1159 flesch: 41 summary: D) Because of airway obstruction, such patients require very low or no PEEP just like asthmatic patients to avoid air trapping. E) Because of high compliance, such patients need low tidal volume and low PEEP to provide better oxygenation. keywords: ards; chest; patients; pneumothorax cache: cord-252085-8dq3gdo8.txt plain text: cord-252085-8dq3gdo8.txt item: #95 of 227 id: cord-253129-v5lck9l7 author: Kim, Kyeong Tae title: Model-based PEEP titration versus standard practice in mechanical ventilation: a randomised controlled trial date: 2020-02-01 words: 8906 flesch: 51 summary: The clinical data are collected by research nurses in the ICU and mechanical ventilation data and oxygenation (bedside monitor) data will be collected by researchers from the UC. Positive end-expiratory pressure (PEEP) at minimum respiratory elastance during mechanical ventilation (MV) in patients with acute respiratory distress syndrome (ARDS) may improve patient care and outcome. keywords: clinical; cure; data; elastance; lung; patients; peep; pressure; rct; recruitment; study; trial; ventilation cache: cord-253129-v5lck9l7.txt plain text: cord-253129-v5lck9l7.txt item: #96 of 227 id: cord-253355-dii5zszf author: Khan, Sheharyar title: Awake Proning: A Necessary Evil During the COVID-19 Pandemic date: 2020-07-03 words: 2759 flesch: 50 summary: One way to manage this excess pressure of fluid build-up around the lung tissues is to relieve the dorsal alveoli by prompting the patient to lie face down on the stomach; this is called awake proning. Since medical institutes are overburdened and limited ventilators are available, awake proning can reduce not only the burden on hospitals but also decrease the need for ventilators. keywords: ards; covid-19; oxygen; patients; proning cache: cord-253355-dii5zszf.txt plain text: cord-253355-dii5zszf.txt item: #97 of 227 id: cord-254083-ea94wn3f author: Fowler, Alexander J. title: COVID-19 Phenotypes and Potential Harm of Conventional Treatments: How to Prove the Hypothesis date: 2020-08-15 words: 1733 flesch: 34 summary: Importantly, the authors suggest that recommended treatment strategies for severe COVID-19 pneumonia based on ARDS management (3) may lead to disease progression and excess harm (1, 2) . For reference, patients enrolled in the PROSEVA (Prone Positioning in Severe ARDS) trial had a mean respiratory system compliance of 35 ml/cm H 2 O (SD, 15) at the time of enrollment (3). keywords: ards; authors; compliance; covid-19; patients cache: cord-254083-ea94wn3f.txt plain text: cord-254083-ea94wn3f.txt item: #98 of 227 id: cord-256051-87alqfkd author: Revzin, Margarita V. title: Multisystem Imaging Manifestations of COVID-19, Part 1: Viral Pathogenesis and Pulmonary and Vascular System Complications date: 2020-10-01 words: 8866 flesch: 29 summary: The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome Hypercoagulability of COVID-19 patients in intensive care unit: A report of thromboelastography findings and other parameters of hemostasis Thromboinflammation and the hypercoagulability of COVID-19 Advance in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic Indirect CT Venography at 80 kVp with Sinogram-Affirmed Iterative Reconstruction Compared to 120 kVp with Filtered Back Projection: Assessment of Image Quality and Radiation Dose Combined Direct and Indirect CT Venography (Combined CTV) in Detecting Lower Extremity Deep Vein Thrombosis Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia Incidence of venous thromboembolism in hospitalized patients with COVID-19 D-dimer is Associated with Severity of Coronavirus Disease 2019: Chest radiography is a less sensitive modality for the detection of COVID-19 lung disease when compared with that CT, with a reported baseline chest radiography sensitivity of 69% (64). keywords: ards; cases; chest; complications; coronavirus; cov-2; covid-19; disease; fig; findings; imaging; infection; lung; patients; pneumonia; sars cache: cord-256051-87alqfkd.txt plain text: cord-256051-87alqfkd.txt item: #99 of 227 id: cord-256385-g1wcfrfi author: Badraoui, Riadh title: Acute respiratory distress syndrome: a life threatening associated complication of SARS-CoV-2 infection inducing COVID-19 date: 2020-08-05 words: 6081 flesch: 37 summary: The damaged endothelia show much more permeability to both water and proteins (exudate) and disrupt the alveolar capillary barrier (Kao et al., 2015; Vasudevan et al., 2004) . Reich et al., 2008; Yang et al., 2015; keywords: ace2; acute; ards; coronavirus; cov-2; covid-19; et al; infection; protein; receptor; sars; syndrome cache: cord-256385-g1wcfrfi.txt plain text: cord-256385-g1wcfrfi.txt item: #100 of 227 id: cord-257613-o0q7hvn3 author: Shafiee, Abbas title: Coronavirus disease 2019: A tissue engineering and regenerative medicine perspective date: 2020-08-21 words: 3434 flesch: 33 summary: Over the COVID-19 outbreak, the funding for many TERM projects is being cut, which has a significant impact on the present and future of Current clinical trials highlight the potential benefits of stem cell therapies for COVID-19 patients. Effective multi-institutional collaboration and adequate funding from government and nongovernment sources are also needed to collect and analyze the data from ongoing and new human trials, to better understand the potential benefits of stem cell therapies for COVID-19 patients. keywords: acute; cells; covid-19; mesenchymal; mscs; stem; syndrome; therapies; tissue; treatment cache: cord-257613-o0q7hvn3.txt plain text: cord-257613-o0q7hvn3.txt item: #101 of 227 id: cord-258087-93yfs7ve author: Flores, Carlos title: A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury date: 2008-10-25 words: 4740 flesch: 28 summary: Positive genetic association studies with acute lung injury/acute respiratory distress syndrome susceptibility and/or outcome (by year of publication) Percentage of studies scored as adequate for 14 criteria (x-axis) used for the quality assessment of genetic association studies supporting susceptibility and/or outcome in acute lung injury Percentage of studies scored as adequate for 14 criteria (x-axis) used for the quality assessment of genetic association studies supporting susceptibility and/or outcome in acute lung injury. key: cord-258087-93yfs7ve authors: Flores, Carlos; del Mar Pino-Yanes, Maria; Villar, Jesús title: A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury date: 2008-10-25 journal: Crit Care DOI: 10.1186/cc7098 sha: doc_id: 258087 cord_uid: 93yfs7ve INTRODUCTION: keywords: acute; ali; ards; association; genetic; injury; lung; outcome; studies; susceptibility cache: cord-258087-93yfs7ve.txt plain text: cord-258087-93yfs7ve.txt item: #102 of 227 id: cord-258896-ck7lh9rg author: Perez-Nieto, Orlando Ruben title: Impact of Asynchronies in Acute Respiratory Distress Syndrome Due to Coronavirus Disease 2019 date: 2020-08-20 words: 823 flesch: 36 summary: Patients with ARDS due to COVID-19 that needed intubation and IMV present a challenge for the physician and have been associated with a mortality rate of 24.5% (2) , despite this, to this date, it has not been described the prevalence of asynchronies in patients with ARDS because of COVID-19 infection and its relationship with the prognosis of their disease. Neuromuscular blockade (NMB) for 24 to 48 hours could be an alternative to avoid triggering asynchronies in this type of patient; NMB has been shown to improve oxygenation, reduce the prevalence of barotrauma and is associated with a reduction in mortality in patients with ARDS (5) . keywords: asynchronies; covid-19; patients cache: cord-258896-ck7lh9rg.txt plain text: cord-258896-ck7lh9rg.txt item: #103 of 227 id: cord-259204-27t269pd author: Grimaldi, D. title: Characteristics and outcomes of Acute Respiratory Distress Syndrome related to COVID-19 in Belgian and French Intensive Care Units according to antiviral strategies. The COVADIS multicenter observational study. date: 2020-07-07 words: 3879 flesch: 45 summary: The Lancet HIV Ritonavir-induced acute kidney injury: kidney biopsy findings and review of literature Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China Kidney disease is associated with in-hospital death of patients with COVID-19 Impact of Early Acute Kidney Injury on Management and Outcome in Patients With Acute Respiratory Distress Syndrome: A Secondary Analysis of a Multicenter Observational Study Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis Lopinavir pharmacokinetics in COVID-19 patients Comparison of Charlson comorbidity index with SAPS and APACHE scores for prediction of mortality following intensive care Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19 Methods Observational multicenter cohort of patients with moderate to severe Covid-19 ARDS, comparing antiviral strategies (none, hydroxychloroquine (HCQ), lopinavir/ritonavir (L/R), others (combination or remdesivir). keywords: acute; aki; covid-19; data; day; patients; study; treatment; vfd cache: cord-259204-27t269pd.txt plain text: cord-259204-27t269pd.txt item: #104 of 227 id: cord-260577-t4w4pw12 author: Imai, Yumiko title: The renin–angiotensin system in acute respiratory distress syndrome date: 2006-08-07 words: 2983 flesch: 46 summary: [1, 2] , whereas ACE2 reduces angiotensin II levels [3, 4] and is a negative regulator of the system. [1, 2] , whereas ACE2 reduces angiotensin II levels [3, 4] . keywords: ace2; acute; angiotensin; ards; lung; sars cache: cord-260577-t4w4pw12.txt plain text: cord-260577-t4w4pw12.txt item: #105 of 227 id: cord-261146-ppe8br4z author: Mohammed, Amira title: Δ9-Tetrahydrocannabinol Prevents Mortality from Acute Respiratory Distress Syndrome through the Induction of Apoptosis in Immune Cells, Leading to Cytokine Storm Suppression date: 2020-08-28 words: 9710 flesch: 39 summary: This was associated with immune cell apoptosis involving the mitochondrial pathway, as suggested by single-cell RNA sequencing. Together, our data indicate that THC may have beneficial effects on ARDS by promoting immune cell apoptosis via the downregulation of miR-185-3p. keywords: acute; analysis; apoptosis; ards; cells; covid-19; cytochrome; data; expression; figure; genes; lung; mice; mir-185; seb; seb+thc; seb+veh; study; t cells; thc; treatment cache: cord-261146-ppe8br4z.txt plain text: cord-261146-ppe8br4z.txt item: #106 of 227 id: cord-261370-jp5sqqwc author: Bollag, Wendy B. title: Phosphatidylglycerol and Surfactant: A Potential Treatment for COVID-19? date: 2020-09-16 words: 4105 flesch: 27 summary: Journal of leukocyte biology Phosphatidylglycerol inhibits toll-like receptor-mediated inflammation by danger-associated molecular patterns Soy phosphatidylglycerol reduces inflammation in a contact irritant ear edema mouse model in vivo Pathogen-associated molecular patterninduced TLR2 and TLR4 activation increases keratinocyte production of inflammatory mediators and is inhibited by phosphatidylglycerol 18:1/18:1-Dioleoyl-phosphatidylglycerol prevents alveolar epithelial apoptosis and profibrotic stimulus in a neonatal piglet model of acute respiratory distress syndrome Phosphatidylglycerol provides short-term prophylaxis against respiratory syncytial virus infection COVID-19: towards understanding of pathogenesis SARS-CoV replicates in primary human alveolar type II cell cultures but not in type I-like cells Innate immune response of human alveolar type II cells infected with severe acute respiratory syndrome-coronavirus Pathogenesis of COVID-19 from a cell biology perspective Role of lung surfactant in respiratory disease: current knowledge in large animal medicine Understanding the principle biophysics concepts of pulmonary surfactant in health and disease. A key role of pulmonary surfactant is to reduce surface tension and prevent alveolar atelectasis at end expiration. keywords: ards; covid-19; distress; inflammation; lung; patients; surfactant; syndrome; type cache: cord-261370-jp5sqqwc.txt plain text: cord-261370-jp5sqqwc.txt item: #107 of 227 id: cord-263879-e36l3t1g author: Jamaati, Hamidreza title: A Fourteen-day Experience with Coronavirus Disease 2019 (COVID-19) Induced Acute Respiratory Distress Syndrome (ARDS): An Iranian Treatment Protocol date: 2020 words: 1155 flesch: 45 summary: On February 19, 2020, Iran reported its first confirmed cases of COVID-19 and Dr. Masih Daneshvari Hospital was selected as a referral center for COVID-19 cases. The hospital was equipped with a special setup to admit COVID-19 cases. keywords: ards; cases; covid-19; patients cache: cord-263879-e36l3t1g.txt plain text: cord-263879-e36l3t1g.txt item: #108 of 227 id: cord-266067-wrouqdcj author: Haywood, Nathan title: Isolated Lung Perfusion in the Management of Acute Respiratory Distress Syndrome date: 2020-09-17 words: 6944 flesch: 42 summary: This review presents current tenants of ARDS management and isolated lung perfusion, with a focus on how ex vivo lung perfusion (EVLP) has paved the way for current investigations utilizing in vivo lung perfusion (IVLP) in the treatment of severe ARDS. Here, early animal studies have demonstrated the ability of in vivo lung perfusion (IVLP) to rehabilitate sepsis-induced ARDS keywords: acute; ards; donor; evlp; injury; ivlp; lung; perfusion; treatment; use; vivo cache: cord-266067-wrouqdcj.txt plain text: cord-266067-wrouqdcj.txt item: #109 of 227 id: cord-266423-s8lqdpvn author: Jose, Ricardo J. title: Does Coronavirus Disease 2019 Disprove the Obesity Paradox in Acute Respiratory Distress Syndrome? date: 2020-05-22 words: 720 flesch: 44 summary: A meta-analysis Adipose-lung cell crosstalk in the obesity-ARDS paradox Clinical characteristics and outcomes of 112 cardiovascular disease patients infected by 2019-nCoV Early antiviral treatment contributes to alleviate the severity and improve the prognosis of patients with novel coronavirus disease (COVID-19) Perioperative management of obese patients How to ventilate COVID-19 patients. The obesity paradox in ARDS patients has been investigated by Ni et al,1 who conclude that obesity and morbid obesity were associated with a lower mortality rate in patients with ARDS. keywords: obesity; patients cache: cord-266423-s8lqdpvn.txt plain text: cord-266423-s8lqdpvn.txt item: #110 of 227 id: cord-271180-cnrs0zpg author: Rizvi, Saniya title: Cytosorb Filter: An adjunct for survival in the COVID-19 patient in cytokine storm? A case report. date: 2020-09-18 words: 3900 flesch: 47 summary: 2 It has been successfully used in cytokine storm patients previously with septic shock, severe pro-inflammatory state in post-operative conditions. Chest x-ray on hospital day 11 which coincided with the first day of cytokine filter therapy showing persistence of infiltrates, improved aeration and improved right lower lobe consolidation. keywords: blood; covid-19; cytokine; day; filter; hospital; patient; renal; storm; therapy cache: cord-271180-cnrs0zpg.txt plain text: cord-271180-cnrs0zpg.txt item: #111 of 227 id: cord-272937-ala32ub5 author: Zhao, Xuan title: Mesenchymal stem cells represent a potential therapeutic option for coronavirus disease 2019-related acute respiratory distress syndrome date: 2020-06-10 words: 1273 flesch: 36 summary: A mouse model for MERS coronavirus-induced acute respiratory distress syndrome Long term outcomes in survivors of epidemic influenza A (H7N9) virus infection Human infection with highly pathogenic avian influenza A(H7N9) virus Human infection with a novel avian-origin influenza A (H7N9) virus Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology The role of innate leukocytes during influenza virus infection Clinical characteristics of coronavirus fisease 2019 in China Pioglitazone protects mesenchymal stem cells against P-cresol-induced mitochondrial dysfunction via up-regulation of PINK-1 Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing Pluripotency of mesenchymal stem cells derived from adult marrow The effect of acute respiratory distress syndrome on bone marrow-derived mesenchymal stem cells Allogeneic mesenchymal stem cells transplantation in patients with refractory RA Bone marrow derived mesenchymal stem cells inhibit inflammation and preserve vascular endothelial integrity in the lungs after hemorrhagic shock Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis Usage of human mesenchymal stem cells in cell-based therapy: advantages and disadvantages The genetic shortcut to antibody drugs Nonsteroidal anti-inflammatory drugs and cardiovascular risk-a matter of indication Transplantation of ACE2 -mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia Clinical study of mesenchymal stem cell treating acute respiratory distress syndrome induced by epidemic influenza A (H7N9) infection: a hint for COVID-19 treatment. keywords: acute; ards; cells; h7n9 cache: cord-272937-ala32ub5.txt plain text: cord-272937-ala32ub5.txt item: #112 of 227 id: cord-273426-55vu6b3u author: Iba, Toshiaki title: Coagulopathy of Coronavirus Disease 2019 date: 2020-05-26 words: 4539 flesch: 22 summary: Platelet counts in COVID-19 patients are variable depending on the reported studies. The potential for increases in platelet counts in COVID-19 patients is suspected to be caused by increased proinflammatory cytokines such as interleukin (IL)-1β and IL-6 produced by the macrophages and monocytes in the lung (26) , and activated platelets may contribute to the lung injury (27) . keywords: acute; coagulation; coagulopathy; coronavirus; covid-19; disease; levels; patients; thrombosis cache: cord-273426-55vu6b3u.txt plain text: cord-273426-55vu6b3u.txt item: #113 of 227 id: cord-276927-rxudwp2v author: Barbas, Carmen Sílvia Valente title: Goal-Oriented Respiratory Management for Critically Ill Patients with Acute Respiratory Distress Syndrome date: 2012-08-23 words: 8003 flesch: 26 summary: Revaluation of ARDS patients on the third day of evolution (Sequential Organ Failure Assessment (SOFA), biomarkers and response to infection therapy) allows changes in the initial treatment plans and can help decrease ARDS mortality. Fibrosis can be evident histologically as early as one week after the onset of ARDS and procollagen III peptide, a precursor of collagen synthesis, can be elevated in bronchoalveolar lavage fluid of ARDS patients at the time of tracheal intubation, its increment being associated with a poor ARDS prognosis. keywords: acute; ards; distress; injury; lung; mortality; oxygenation; patients; peep; pressure; pulmonary; risk; study; syndrome; ventilation; ventilatory cache: cord-276927-rxudwp2v.txt plain text: cord-276927-rxudwp2v.txt item: #114 of 227 id: cord-277031-yt0lafin author: McGurk, Kevin title: A primer on proning in the emergency department date: 2020-07-04 words: 2033 flesch: 33 summary: Kevin McGurk MD https://orcid.org/0000-0002-4843-6837 Improved oxygenation in patients with acute respiratory failure: the prone position A Novel coronavirus from patients with pneumonia in China Efficacy and safety of early prone positioning combined with HFNC or NIV in moderate to severe ARDS: a multi-center prospective cohort study Lower mortality of COVID-19 by early recognition and intervention: experience from Jiangsu Province Gas exchange in the prone posture Efficacy of prone position in acute respiratory distress syndrome patients: a pathophysiology-based review Acute respiratory distress syndrome Prone positioning in acute respiratory distress syndrome. Semin Respir Critl Care Med Effect of mechanical ventilation in the prone position on clinical outcomes in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis Prone positioning in severe acute respiratory distress syndrome Treatment of ARDS with prone positioning Guidelines on the management of acute respiratory distress syndrome Prone positioning improves oxygenation in spontaneously breathing nonintubated patients with hypoxemic acute respiratory failure: a retrospective study Respiratory parameters in patients with COVID-19 after using noninvasive ventilation in the prone position outside the intensive care unit Early self-proning in awake, non-intubated patients in the emergency department: a single ED's experience during the COVID-19 pandemic Early prone position at the emergency room in acute respiratory distress syndrome: a pilot study Prone position augments recruitment and prevents alveolar overinflation in acute lung injury Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis Physiological effect of prone position in children with severe bronchiolitis: a randomized cross-over study (BRONCHIO-DV) Prone position for acute respiratory failure in adults Formal guidelines: management of acute respiratory distress syndrome keywords: acute; lung; patients; position; positioning cache: cord-277031-yt0lafin.txt plain text: cord-277031-yt0lafin.txt item: #115 of 227 id: cord-277590-u0uf88e7 author: Gage, Ann title: Reacquainting Cardiology With Mechanical Ventilation in Response to the COVID-19 Pandemic date: 2020-03-27 words: 587 flesch: 37 summary: One of the few bright spots in this pandemic has been the resurgence of interdisciplinary team- Clinical characteristics of coronavirus disease 2019 in China COVID-19 and Italy: what next? Acute respiratory distress syndrome: advances in diagnosis and treatment Acute respiratory distress syndrome: pathophysiology and therapeutic options ARDS Definition Task Force Acute respiratory distress syndrome: the Berlin definition Surviving sepsis campaign: guidelines on the management of critically ill adults with coronavirus disease 2019 (COVID-19) Prone positioning reduces mortality from acute respiratory distress syndrome in the low tidal volume era: a meta-analysis Care for critically ill patients with COVID-19 for the ACC Critical Care Cardiology Working Group. keywords: ards; pressure cache: cord-277590-u0uf88e7.txt plain text: cord-277590-u0uf88e7.txt item: #116 of 227 id: cord-277648-9kxwkcbl author: Overholt, Kalon J. title: Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution date: 2020-06-19 words: 10011 flesch: 34 summary: Notably, the concerted TNF-α/NF-κB pathway enrichment across BALF cell types is indicative of a strong upregulation of TNFAIP3 and NFKBIA. Exploring the expression of these 16 ligands across the diversity of BALF cell types indicates that MPs and neutrophils may act as sender cells signaling to the epithelium, as suggested in recent reports [21, 28, 53] . keywords: analysis; ards; balf; cell; control; covid-19; disease; donors; expression; figure; gene; ligands; lung; patients; severity; type cache: cord-277648-9kxwkcbl.txt plain text: cord-277648-9kxwkcbl.txt item: #117 of 227 id: cord-277788-6ls21tkr author: Nelson, Brian C title: Clinical Outcomes Associated with Methylprednisolone in Mechanically Ventilated Patients with COVID-19 date: 2020-08-09 words: 3556 flesch: 45 summary: On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine Clinical management of severe acute respiratory infection when COVID-19 is suspected Corticosteroids as adjunctive therapy in the treatment of influenza: an updated cochrane systematic review and meta-analysis Factors associated with psychosis among patients with severe acute Respiratory Syndrome: a case-control study Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome Effect of hypercortisone on development of shock among patients with severe sepsis Hydrocortisone therapy for patients with septic shock Early short course corticosteroids in hospitalized patients with COVID-19 Effect of systemic glucocorticoids on mortality or mechanical ventilation in patients with COVID-19 A c c e p t e d M a n u s c r i Clinical outcomes associated with the use of methylprednisolone were assessed in an unmatched, case-control study; a subset of patients also underwent propensity-score matching. keywords: corticosteroids; covid-19; days; methylprednisolone; patients; study cache: cord-277788-6ls21tkr.txt plain text: cord-277788-6ls21tkr.txt item: #118 of 227 id: cord-278249-vvhq9vgp author: Blot, Mathieu title: CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS date: 2020-11-02 words: 6261 flesch: 38 summary: COVID-19 ARDS patients required mechanical ventilation (MV) for significantly longer, even after adjustment for potential confounders. It should be evaluated as a candidate biomarker that may predict the duration of MV in COVID-19 ARDS patients. keywords: ards; ards patients; concentrations; covid-19; covid-19 ards; csf; cxcl10; cytokine; dna; elf; immune; non; patients; plasma; sars cache: cord-278249-vvhq9vgp.txt plain text: cord-278249-vvhq9vgp.txt item: #119 of 227 id: cord-279440-0mn5b0vv author: Diehl, J-L title: Response to Damiani and colleagues date: 2020-10-14 words: 882 flesch: 37 summary: Ideally, such prospective studies should include COVID-19 ARDS patients and non-COVID-19 ARDS patients as a control group. One important point is that the very vast majority of studies in COVID-19 ARDS patients used, by convenience, ventilatory ratio (VR) as a marker of impaired ventilatory efficacy, as mentioned in Damiani's comment, rather than dead space measurements. keywords: ards; covid-19; damiani; patients cache: cord-279440-0mn5b0vv.txt plain text: cord-279440-0mn5b0vv.txt item: #120 of 227 id: cord-280965-x5ffw843 author: Damiani, Elisa title: Comment on “Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study” date: 2020-10-23 words: 812 flesch: 35 summary: Appropriately designed clinical and laboratory-controlled studies are needed to prove any causal relationship between microvascular derangements and increased dead space ventilation. Several hypotheses are made to explain the pathogenesis of increased V D /V keywords: ards; patients; space cache: cord-280965-x5ffw843.txt plain text: cord-280965-x5ffw843.txt item: #121 of 227 id: cord-281945-jvnjzjds author: Radnis, Caitlin title: Radiographic and clinical neurologic manifestations of COVID-19 related hypoxemia date: 2020-09-06 words: 2814 flesch: 38 summary: In this case series, we describe three cases of hypoxic brain injury seen on magnetic resonance imaging (MRI) in patients with hypoxemia secondary to COVID-19-related ARDS. The lack of severe observed hypoxemia in two of the cases suggests that unrecognized or asymptomatic hypoxemia may play a role in hypoxic brain injury related to COVID-19. keywords: acute; ards; brain; covid-19; hypoxemia; injury; patients cache: cord-281945-jvnjzjds.txt plain text: cord-281945-jvnjzjds.txt item: #122 of 227 id: cord-282151-mai4eggf author: Bai, Lu title: Clinical Features of Pneumonia Caused by 2009 Influenza A(H1N1) Virus in Beijing, China date: 2015-12-16 words: 3765 flesch: 53 summary: key: cord-282151-mai4eggf authors: Bai, Lu; Gu, Li; Cao, Bin; Zhai, Xiao-Li; Lu, Min; Lu, Yong; Liang, Li-Rong; Zhang, Lei; Gao, Zi-Fen; Huang, Ke-Wu; Liu, Ying-Mei; Song, Shu-Fan; Wu, Lin; Yin, Yu-Dong; Wang, Chen title: Clinical Features of Pneumonia Caused by 2009 Influenza A(H1N1) Virus in Beijing, China date: 2015-12-16 journal: Chest DOI: 10.1378/chest.10-1036 sha: doc_id: 282151 cord_uid: mai4eggf BACKGROUND: Data on symptoms and radiographic changes in patients with pandemic 2009 influenza A(H1N1) (A[H1N1]) pneumonia during convalescence have not been reported. In our initial report of the A(H1N1) virus infection in China, the majority of patients had mild illness. keywords: a(h1n1; ards; group; infl; lung; manuscript; patients; uenza cache: cord-282151-mai4eggf.txt plain text: cord-282151-mai4eggf.txt item: #123 of 227 id: cord-282474-74273qgk author: Roehrig, Stefan title: Flow controlled ventilation in Acute Respiratory Distress Syndrome associated with COVID-19: A structured summary of a study protocol for a randomised controlled trial date: 2020-09-11 words: 2881 flesch: 51 summary: key: cord-282474-74273qgk authors: Roehrig, Stefan; Ait Hssain, Ali; Shallik, Nabil Al Hamid; Elsaid, Ingi Mohamed A.; Mustafa, Salma Faisal; Smain, Osama A. M.; Molokhia, Ashraf Abdulla; Lance, Marcus D. title: Flow controlled ventilation in Acute Respiratory Distress Syndrome associated with COVID-19: A structured summary of a study protocol for a randomised controlled trial date: 2020-09-11 journal: Trials DOI: 10.1186/s13063-020-04708-1 sha: doc_id: 282474 cord_uid: 74273qgk OBJECTIVES: This study aims to demonstrate the positive effects on oxygenation of flow-controlled ventilation compared to conventionally ventilated patients (pressure control ventilation) in patients suffering from ARDS associated with COVID-19. keywords: ards; data; flow; patients; pressure; study; ventilation cache: cord-282474-74273qgk.txt plain text: cord-282474-74273qgk.txt item: #124 of 227 id: cord-282547-ehr9aaix author: Chang, Jae C. title: Acute Respiratory Distress Syndrome as an Organ Phenotype of Vascular Microthrombotic Disease: Based on Hemostatic Theory and Endothelial Molecular Pathogenesis date: 2019-11-28 words: 11513 flesch: 27 summary: Experimental study Coagulation abnormalities in acute lung injury and sepsis Viral hemorrhagic fevers due to endotheliopathyassociated disseminated intravascular microthrombosis and hepatic coagulopathy: pathogenesis based on two activation theory of the endothelium Long-term outcome of acute respiratory distress syndrome caused by severe acute respiratory syndrome (SARS): an observational study Molecular pathology of emerging coronavirus infections Platelet and TRALI: from blood component to organism Transfusion-related acute lung injury (TRALI): a serious adverse event of blood transfusion Benchto-bedside review: brain-lung interaction in the critically ill-a pending issue revisited Early hepatic dysfunction is associated with a worse outcome in patients presenting with acute respiratory distress syndrome: a post-hoc analysis of the ACURASYS and PROSEVA studies Acute kidney injury in children with acute respiratory failure Acute pancreatitis and acute respiratory distress syndrome complicating plasmodium vivax malaria Acute lung injury and ARDS in acute pancreatitis: mechanisms and potential intervention The risk factors, incidence, and prognosis of ARDS following septicemia Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors, and outcomes Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis Sepsisassociated disseminated intravascular coagulation and thromboembolic disease Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients Systemic inflammation and disseminated intravascular coagulation in early stage of ALI and ARDS: role of neutrophil and endothelial activation The pathologist's approach to acute lung injury Acute respiratory distress syndrome and diffuse alveolar damage. New insights on a complex relationship Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore A decade after SARS: strategies for controlling emerging coronaviruses Current understanding of the pathophysiology of thrombotic thrombocytopenic purpura Clinical features of severe wasp sting patients with dominantly toxic reaction: analysis of 1091 cases Chronology of histological lesions in acute respiratory distress syndrome with diffuse alveolar damage: a prospective cohort study of clinical autopsies Pulmonary pathology of acute respiratory distress syndrome ARDS and diffuse alveolar damage: a pathologist's perspective Thrombocytopenia in critically Ill patients: clinical and laboratorial behavior and its correlation with short-term outcome during hospitalization keywords: activation; acute; ards; dic; distress; distress syndrome; endothelial; hemostasis; mods; organ; path; pathogenesis; syndrome; ttp; ulvwf; vmtd cache: cord-282547-ehr9aaix.txt plain text: cord-282547-ehr9aaix.txt item: #125 of 227 id: cord-283779-mudwcypl author: Lauretani, Fulvio title: Assessment and treatment of older individuals with COVID-19 multi-system disease: clinical and ethical implications date: 2020-05-11 words: 9739 flesch: 35 summary: As a consequence of multimorbidity, polypharmacy defined as the number of drugs reported at hospital admission and the potential drug-drug interactions require a careful evaluation in older COVID-19 patients. These principles have been often ignored, especially in older COVID-19 patients. keywords: acute; care; coronavirus; covid-19; day; days; disease; infection; mortality; nutritional; patients; phase; pulmonary; risk; sars; symptoms; syndrome; treatment; use; virus cache: cord-283779-mudwcypl.txt plain text: cord-283779-mudwcypl.txt item: #126 of 227 id: cord-283780-h4lwzpl9 author: Zhang, John J Y title: Risk Factors of Severe Disease and Efficacy of Treatment in Patients Infected with COVID-19: A Systematic Review, Meta-Analysis and Meta-Regression Analysis date: 2020-05-14 words: 3122 flesch: 43 summary: At baseline, the quality of evidence derived from a review of COVID-19 studies was assessed as low, owing to their observational nature. The quality of included studies was assessed using the Joanna Briggs Institute (JBI) checklist for prevalence studies and the JBI checklist for case series [10] . keywords: analysis; covid-19; meta; patients; studies cache: cord-283780-h4lwzpl9.txt plain text: cord-283780-h4lwzpl9.txt item: #127 of 227 id: cord-284332-p4c1fneh author: Bosma, Karen J. title: Pharmacotherapy for Prevention and Treatment of Acute Respiratory Distress Syndrome: Current and Experimental Approaches date: 2012-09-19 words: 14538 flesch: 29 summary: The use of an inflammation-modulating diet in patients with acute lung injury or acute respiratory distress syndrome: a metaanalysis of outcome data Efficacy of an expanded ventilator bundle for the reduction of ventilatorassociated pneumonia in the medical intensive care unit Continuous aspiration of subglottic secretions in the prevention of ventilatorassociated pneumonia in the postoperative period of major heart surgery Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial Thromboprophylaxis in medicalsurgical critically ill patients Stress ulcer prophylaxis in critically ill patients: resolving discordant meta-analyses Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial Effects of physical training on functional status in patients with prolonged mechanical ventilation Recent trends in acute lung injury mortality: 1996-2005 Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis Effect of prone positioning in patients with acute respiratory distress syndrome: a metaanalysis Effect of mechanical ventilation in the prone position on clinical outcomes in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis1 Hemodynamic and gas exchange response to inhaled nitric oxide and prone positioning in acute respiratory distress syndrome patients High-frequency oscillatory ventilation in adults: the Toronto experience High-frequency oscillatory ventilation for adult patients with ARDS Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial Extracorporeal membrane oxygenation for 2009 influenza A (H1N1) acute respiratory distress syndrome Ketoconazole prevents acute respiratory failure in critically ill surgical patients A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome Development, implementation, and evaluation of a ketoconazole practice guideline for ARDS prophylaxis Angiotensin-converting enzyme inhibitor captopril prevents oleic acid-induced severe acute lung injury in rats Rosiglitazone attenuates the severity of sodium taurocholate-induced acute pancreatitis and pancreatitis-associated lung injury Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: phase IIb, multicenter, randomized, placebo-controlled, clinical trial Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial The Beta-Agonist Lung Injury Trial (BALTI): a randomized placebo-controlled clinical trial Randomized, placebo-controlled trial of an aerosolized beta-2 adrenergic agonist (albuterol) for the treatment of acute lung injury Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome: Exosurf Acute Respiratory Distress Syndrome Sepsis Study Group Bovine surfactant therapy for patients with acute respiratory distress syndrome Venticute in patients with pneumonia or aspiration of gastric contents and intubation/ventilation/oxygenation impairment (BY2001/M1-007) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome The American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury Arachidonic acid remodeling in human inflammatory cells migrating to the lung in vivo Recent advances in genetic predisposition to clinical acute lung injury Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock Pharmacotherapy of acute lung injury and acute respiratory distress syndrome Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? keywords: acute; ali; alveolar; ards; day; distress; group; injury; lung; mortality; neutrophil; patients; phase; results; risk; studies; study; surfactant; syndrome; treatment; trial; ventilation cache: cord-284332-p4c1fneh.txt plain text: cord-284332-p4c1fneh.txt item: #128 of 227 id: cord-284598-ksoonwf9 author: Liu, Shan title: Mesenchymal stem cells as a potential therapy for COVID-19 date: 2020-05-04 words: 1721 flesch: 35 summary: The dynamic data for COVID-19 epidemic worldwide Incidence and outcomes of acute lung injury Mesenchymal stem cell-based therapy of inflammatory lung diseases: current understanding and future perspectives Clinical application of mesenchymal stem cell-derived extracellular vesicle-based therapeutics for inflammatory lung diseases Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs Proteolytic potential of the MSC exosome proteome: implications for an exosome-mediated delivery of therapeutic proteasome Human mesenchymal stem cells modulate allogeneic immune cell responses Human mesenchymal stem cells modulate B-cell functions Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37 Mitochondrial transfer from bone-marrowderived stromal cells to pulmonary alveoli protects against acute lung injury Acute respiratory distress syndrome: the Berlin definition Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung Fifty years of research in ARDS. Biology and potential therapeutic value Mesenchymal stromal cells for the prophylaxis and treatment of graft-versus-host disease-a meta-analysis Mesenchymal stromal cell treatment prevents H9N2 avian influenza virus-induced acute lung injury in mice Human mesenchymal stromal cells reduce influenza a H5N1-associated acute lung injury in vitro and in vivo Mesenchymal stem cell-derived extracellular vesicles attenuate influenza virus-induced acute lung injury in a pig model In vivo effects of mesenchymal stromal cells in two patients with severe acute respiratory distress syndrome News conference for joint prevention and control measure of COVID-19 by China's State Council Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations keywords: acute; ards; cells; covid-19; mesenchymal; mscs cache: cord-284598-ksoonwf9.txt plain text: cord-284598-ksoonwf9.txt item: #129 of 227 id: cord-285202-aiap6z9u author: Short, Briana title: Rapid implementation of a mobile prone team during the COVID-19 pandemic date: 2020-08-25 words: 1728 flesch: 40 summary: The rapid development of a mobile prone team safely provided prone positioning to a large number of COVID-19 patients with moderate-to-severe ARDS. During the COVID-19 pandemic, the rapid development and implementation of a mobile prone team allowed for increased capacity to prone patients with moderate-to-severe ARDS in ICUs beyond the MICUs to meet the surge of critically ill patients during the height of the pandemic. keywords: ards; covid-19; patients; positioning; team cache: cord-285202-aiap6z9u.txt plain text: cord-285202-aiap6z9u.txt item: #130 of 227 id: cord-285684-iiqyzqsb author: Li, Jin-ze title: Mechanically Stretched Mesenchymal Stem Cells Can Reduce the Effects of LPS-Induced Injury on the Pulmonary Microvascular Endothelium Barrier date: 2020-10-30 words: 4629 flesch: 43 summary: Biology and potential therapeutic value The hepatocyte growth factorexpressing character is required for mesenchymal stem cells to protect the lung injured by lipopolysaccharide in vivo MTOR/STAT-3 pathway mediates mesenchymal stem cell-secreted hepatocyte growth factor protective effects against lipopolysaccharideinduced vascular endothelial barrier dysfunction and apoptosis Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a 10 Stem Cells International randomised phase 2a safety trial Mesenchymal stem cells migration homing and tracking Characterization of key mechanisms in transmigration and invasion of mesenchymal stem cells Alveolar dynamics during mechanical ventilation in the healthy and injured lung The micromechanics of lung alveoli: structure and function of surfactant and tissue components Why the impact of mechanical stimuli on stem cells remains a challenge Ventilator Management Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome Respiratory drive in the acute respiratory distress syndrome: pathophysiology, monitoring, and therapeutic interventions Surviving sepsis campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19) Mechanical stimuli differentially control stem cell behavior: morphology, proliferation, and differentiation Mechanically induced formation and maturation of 3D-matrix adhesions (3DMAs) in human mesenchymal stem cells Response of mesenchymal stem cells to the biomechanical environment of the endothelium on a flexible tubular silicone substrate Mechanical stimulation induces morphological and phenotypic changes in bone marrow-derived progenitor cells within a three-dimensional fibrin matrix Mechanical stress and the induction of lung fibrosis via the midkine signaling pathway Co-regulation of transcellular and paracellular leak across microvascular endothelium by dynamin and Rac FIP200 is required for the cellautonomous maintenance of fetal hematopoietic stem cells Minimal criteria for defining multipotent mesenchymal stromal cells. Treatment with LPS can also alter the apoptotic status of endothelial barrier cells and badly damage the paracellular architecture of causing the endothelial barrier to function abnormally and producing pulmonary edema [43] . keywords: barrier; cells; endothelial; lps; mechanical; mesenchymal; mscs; permeability; stem; stretch cache: cord-285684-iiqyzqsb.txt plain text: cord-285684-iiqyzqsb.txt item: #131 of 227 id: cord-285955-fzm6036f author: Nasir, N. title: Treatment of ARDS and hyperinflammation in COVID-19 with IL-6 antagonist Tocilizumab: a tertiary care experience from Pakistan date: 2020-06-26 words: 2059 flesch: 41 summary: We conducted a retrospective descriptive study from Feb 2020 to May 2020 on COVID-19 patients with ARDS and hyperinflammation characterized by raised CRP and/or ferritin. While limited studies from China have shown improved outcomes in COVID-19 patients with hyperinflammation and ARDS 9 , a study from Italy did not show significant mortality benefit 10 . keywords: ards; covid-19; patients; preprint; tocilizumab cache: cord-285955-fzm6036f.txt plain text: cord-285955-fzm6036f.txt item: #132 of 227 id: cord-286133-h8jgwe4z author: Gattinoni, Luciano title: Reply by Gattinoni et al. to Hedenstierna et al., to Maley et al., to Fowler et al., to Bhatia and Mohammed, to Bos, to Koumbourlis and Motoyama, and to Haouzi et al. date: 2020-08-15 words: 1935 flesch: 42 summary: [online ahead of print Endothelial cell infection and endotheliitis in COVID-19 Hypercoagulability of COVID-19 patients in intensive care unit: a report of thromboelastography findings and other parameters of hemostasis Mechanical ventilation to minimize progression of lung injury in acute respiratory failure Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome: the Multicenter Trail Group on Tidal Volume reduction in ARDS Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients Fifty years of research in ARDS why is acute respiratory distress syndrome so important for critical care? Reply by Pan et al. to Haouzi et al. Dr. Bos, Dr. Maley and colleagues, and Dr. Haouzi and colleagues in their letters conclude, as do many others in our scientific community, that COVID-19 pneumonia is not atypical but fits the conventional ARDS definition and that higher respiratory system compliance (Crs) may be a normal finding in the syndrome. keywords: ards; covid-19; lung; patients cache: cord-286133-h8jgwe4z.txt plain text: cord-286133-h8jgwe4z.txt item: #133 of 227 id: cord-286771-77hs34jm author: Cruces, Pablo title: A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection date: 2020-08-10 words: 5936 flesch: 35 summary: We showed preliminary experimental data that regional lung strain and heterogeneity can be identified in acutely injured lungs under unassisted spontaneous breathing. The role of three-dimensionality and alveolar pressure in the distribution and amplification of alveolar stresses Does regional lung strain correlate with regional inflammation in acute respiratory distress syndrome during nonprotective ventilation? keywords: acute; ards; breathing; covid-19; failure; injury; lung; patients; regional; sili; strain; ventilation cache: cord-286771-77hs34jm.txt plain text: cord-286771-77hs34jm.txt item: #134 of 227 id: cord-286901-whvq8y1p author: Vidali, Sofia title: D-dimer as an indicator of prognosis in SARS-CoV-2 infection: a systematic review date: 2020-07-13 words: 4281 flesch: 31 summary: D-dimer was increased and significantly higher in COVID-19 patients compared with healthy controls, in COVID-19 patients with severe disease or a composite end-point compared with non-severe disease, in ARDS compared with non-ARDS patients and in deceased ARDS patients compared with ARDS patients who survived (all p<0.001). COVID-19 patients treated with anticoagulants demonstrated lower mortality compared with those not treated (p=0.017). keywords: ards; coagulation; coronavirus; covid-19; dimer; disease; patients; sars; work cache: cord-286901-whvq8y1p.txt plain text: cord-286901-whvq8y1p.txt item: #135 of 227 id: cord-290392-kpjp0sx4 author: Li, Xu title: Acute respiratory failure in COVID-19: is it “typical” ARDS? date: 2020-05-06 words: 2579 flesch: 45 summary: Since severe COVID-19 patients may deteriorate rapidly, patients receiving HFNO should be closely monitored and cared for by experienced personnel capable of endotracheal intubation at any time. It was possible that due to less damage to the endothelial cells, other organ functions were less involved in COVID-19 patients. keywords: ards; coronavirus; covid-19; patients; treatment cache: cord-290392-kpjp0sx4.txt plain text: cord-290392-kpjp0sx4.txt item: #136 of 227 id: cord-290460-d5e6y2r8 author: Knighton, Andrew J. title: Multi-factorial barriers and facilitators to high adherence to lung-protective ventilation using a computerized protocol: a mixed methods study date: 2020-07-28 words: 6503 flesch: 38 summary: Impact of the initial approach to LPV CDS tool implementation (Table 6) Strategies implemented during the initial rollout led to a meaningful increase in adherence rates for both LPV and the LPV CDS tool but were not sufficient alone to achieve high adherence. We analyzed 47 key informant interviews of ICU physicians, respiratory therapists (RTs), and nurses in 3 of the ICUs using a qualitative content analysis paradigm to investigate site variation as defined by adherence level (low, medium, high) and to identify barriers and facilitators to LPV and LPV CDS tool use. keywords: adherence; ards; barriers; cds tool; implementation; lpv; lpv cds; patients; site; study; tool; use; ventilation cache: cord-290460-d5e6y2r8.txt plain text: cord-290460-d5e6y2r8.txt item: #137 of 227 id: cord-291481-ov1gkgpc author: Bonizzoli, Manuela title: Human herpesviruses respiratory infections in patients with acute respiratory distress (ARDS) date: 2016-05-02 words: 5002 flesch: 40 summary: An independent risk factor for ICU patients with ARDS is an impaired immunophenotype. It has been suggested that the presence of HSV1 in the respiratory samples of ICU patients correlates with the duration of tracheal intubation keywords: ards; dna; herpesviruses; icu; infection; influenza; patients; samples; tract cache: cord-291481-ov1gkgpc.txt plain text: cord-291481-ov1gkgpc.txt item: #138 of 227 id: cord-292862-ezrkg0dc author: Myerson, Jacob W. title: Supramolecular Organization Predicts Protein Nanoparticle Delivery to Neutrophils for Acute Lung Inflammation Diagnosis and Treatment date: 2020-04-18 words: 14319 flesch: 42 summary: Our data thus indicate that NAP tropism for neutrophils in inflamed mouse lungs may be recapitulated in human lungs. 6, 10, 14, 18 Single cell suspensions prepared from mouse lungs were probed by flow cytometry to further characterize pulmonary neutrophils in naïve mice and in mice following LPS-induced inflammation. keywords: albumin; anti; cells; data; dbco; figure; human; igg; inflammation; injury; liposomes; lps; lungs; lysozyme; mice; minutes; nanoparticles; naps; naïve; neutrophils; nps; protein; pulmonary; uptake cache: cord-292862-ezrkg0dc.txt plain text: cord-292862-ezrkg0dc.txt item: #139 of 227 id: cord-293259-o51fnvuw author: Sinaei, Reza title: Why COVID-19 is less frequent and severe in children: a narrative review date: 2020-09-25 words: 7048 flesch: 41 summary: Genomic contributions and opportunities Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome Interleukin-1 receptor antagonist is associated with pediatric acute respiratory distress syndrome and worse outcomes in children with acute respiratory failure Identification of novel single nucleotide polymorphisms associated with acute respiratory distress syndrome by exome-seq Association of polymorphisms in genes of factors involved in regulation of splicing of cystic fibrosis transmembrane conductance regulator mRNA with acute respiratory distress syndrome in children with pneumonia Genetic gateways to COVID-19 infection: implications for risk, severity, and outcomes Differential expression of COVID-19-related genes in European Americans and African Americans Analysis of genetic host response risk factors in severe COVID-19 patients Down-regulated gene expression spectrum and immune responses changed during the disease progression in COVID-19 patients Genomewide association study of severe Covid-19 with respiratory failure The authors thank the staff and participants of this In a retrospective review of all COVID-19 patients treated at Wuhan union hospital until March 20, 2020, Mi et al. evaluated the correlation between prior exposures to MP and better clinical response in COVID-19 patients. keywords: adults; age; cases; children; coronavirus; cov-2; covid-19; disease; infection; mis; patients; pediatric; response; sars; syndrome cache: cord-293259-o51fnvuw.txt plain text: cord-293259-o51fnvuw.txt item: #140 of 227 id: cord-293736-nyvwv31m author: Méry, Geoffroy title: COVID-19: Underlying Adipokine Storm and Angiotensin 1-7 Umbrella date: 2020-07-21 words: 5760 flesch: 30 summary: Oral or parenteral Ang1-7 supplementation could be a therapeutic option to diminish the low-grade systemic inflammation due to adipocyte dysfunction and attenuate the severity of ACE2-mediated injuries consecutive to SARS infection. High plasma levels of IL-6 and the absence of INF-1 have been noted in severe patients (47) , illustrating a sustained innate response that fails to achieve viral clearance and triggers ARDS. keywords: ace2; ang1; angiotensin; coronavirus; cov-2; covid-19; inflammation; obesity; patients; receptor; response; sars; syndrome cache: cord-293736-nyvwv31m.txt plain text: cord-293736-nyvwv31m.txt item: #141 of 227 id: cord-293740-4c3yemi3 author: Ferrando, Carlos title: Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS date: 2020-07-29 words: 4340 flesch: 50 summary: We examined the clinical features, ventilatory management, and clinical outcomes of COVID-19 ARDS patients, and compared some results with other relevant studies in non-COVID-19 ARDS patients. Our findings in a cohort of over 700 patients are in line with preliminary studies of COVID-19 ARDS patients [23, 24] . keywords: ards; covid-19; day; lung; non; patients; pressure; studies; study cache: cord-293740-4c3yemi3.txt plain text: cord-293740-4c3yemi3.txt item: #142 of 227 id: cord-296182-hhswage4 author: Meng, Lingzhong title: Intubation and Ventilation amid the COVID-19 Outbreak: Wuhan’s Experience date: 2020-04-08 words: 6539 flesch: 37 summary: Ventilator management for hypoxemic respiratory failure attributable to H1N1 novel swine origin influenza virus High-frequency oscillatory ventilation versus conventional ventilation for acute respiratory distress syndrome Nursing and infection-control issues during high-frequency oscillatory ventilation Work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndrome: A comparison between volume and pressure-regulated breathing modes Ventilator management for acute respiratory distress syndrome associated with avian influenza A (H7N9) virus infection: A case series Prone positioning in severe acute respiratory distress syndrome Lung recruitment maneuvers for ARDS patients: A systematic review and meta-analysis Recruitment manoeuvres for adults with acute respiratory distress syndrome receiving mechanical ventilation ACURASYS Study Investigators: Neuromuscular blockers in early acute respiratory distress syndrome Early neuromuscular blockade in the acute respiratory distress syndrome Neuromuscular blockade in acute respiratory distress syndrome: A systematic review and meta-analysis of randomized controlled trials ESICM H1N1 Registry Contributors: Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1) v influenza A infection Corticosteroids as adjunctive therapy in the treatment of influenza Corticosteroids as adjunctive therapy in the treatment of influenza: An updated Cochrane systematic review and meta-analysis González-Martín JM; dexamethasone in ARDS network: Dexamethasone treatment for the acute respiratory distress syndrome: A multicentre, randomised controlled trial Extracorporeal membrane oxygenation for 2009 influenza A(H1N1) acute respiratory distress syndrome Extracorporeal life support: The next step in moderate to severe ARDS-A review and meta-analysis of the literature Elbourne D; CESAR trial collaboration: Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): A multicentre randomised controlled trial Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome and posterior probability of mortality benefit in a post hoc Bayesian analysis of a randomized clinical trial A novel coronavirus outbreak of global health concern A review of isolation gowns in healthcare: Fabric and gown properties Prone position for acute respiratory distress syndrome. Approximately 3.2% of patients with COVID-19 required intubation and invasive ventilation at some point in the disease course. keywords: airway; china; covid-19; infection; intubation; lung; oxygenation; patients; pressure; syndrome; ventilation; wuhan cache: cord-296182-hhswage4.txt plain text: cord-296182-hhswage4.txt item: #143 of 227 id: cord-296435-6dergkha author: Wang, Tiehua title: Thrombocytopenia Is Associated with Acute Respiratory Distress Syndrome Mortality: An International Study date: 2014-04-14 words: 4479 flesch: 34 summary: Although not significant, ARDS patients were in the ICU longer (ARDS median = 13 days; non-ARDS median = 9 days; p = 0.21) and on mechanical ventilation longer (ARDS median = 7 days; non-ARDS median = 5 days;p = 0.53) than non-ARDS patients. In contrast, pneumonia (p = 0.002) and external pulmonary injury (p = 0.013) had higher mortality rates in non-ARDS patients. keywords: ards; beijing; boston; cohort; icu; mortality; patients; risk; thrombocytopenia cache: cord-296435-6dergkha.txt plain text: cord-296435-6dergkha.txt item: #144 of 227 id: cord-296656-4q0jdyrh author: van der Stap, Janneke title: Acute respiratoire insufficiëntie date: 2020-07-14 words: 391 flesch: 53 summary: De mortaliteit van ARDS is de afgelopen jaren gedaald van 60% naar 20-40%. je van Nursing gewend bent. keywords: acute; het; van cache: cord-296656-4q0jdyrh.txt plain text: cord-296656-4q0jdyrh.txt item: #145 of 227 id: cord-299125-kuvnwdn6 author: Ikegami, Saya title: Suspected Virus-Inducing Severe Acute Respiratory Distress Syndrome Treated by Multimodal Therapy Including Extracorporeal Membrane Oxygenation and Immune Modulation Therapy date: 2020-06-22 words: 2877 flesch: 38 summary: Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. Acute respiratory distress syndrome: the 2020 Ikegami et al Berlin definition Acute respiratory distress syndrome definition, causes, and pathophysiology Acute respiratory distress syndrome Acute respiratory distress syndrome Coxsackie B1 pneumonia in an adult Extracorporeal life support for adults with respiratory failure and related indications: a review Extracorporeal membrane oxygenation for acute respiratory distress syndrome: EOLIA and beyond Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1) Pneumonia, acute respiratory distress syndrome, and early immune-modulator therapy Corticosteroids in acute lung injury: the dilemma continues The immunomodulatory effects of macrolidesa systematic review of the underlying mechanisms Viral pneumonia and acute respiratory distress syndrome Glycyrrhizic acid inhibits virus growth and inactivates virus particles Research progress of glycyrrhizic acid on antiviral activity Traditional Chinese medicine for COVID-19 treatment Therapeutic control of viral infections: chemotherapy, interferon and gamma globulin Salmonella typhi infection complicated by rhabdomyolysis, pancreatitis and polyneuropathy Rhabdomyolysis associated with infection by Mycoplasma pneumoniae: a case report Tumor necrosis factor and Coxsackie B4 rhabdomyolysis Development of potential antiviral strategy against Coxsackievirus B4 Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in critically ill patients and is defined by the acute onset of non-cardiogenic pulmonary edema, hypoxemia, and the need for mechanical ventilation [1] [2] keywords: ards; case; day; ecmo; lung; pneumonia; therapy; ventilation cache: cord-299125-kuvnwdn6.txt plain text: cord-299125-kuvnwdn6.txt item: #146 of 227 id: cord-301830-nxtfhxjd author: Mauri, Tommaso title: Potential for Lung Recruitment and Ventilation-Perfusion Mismatch in Patients With the Acute Respiratory Distress Syndrome From Coronavirus Disease 2019 date: 2020-04-28 words: 3328 flesch: 32 summary: The recruitment to inflation ratio presented median value higher than previously reported in acute respiratory distress syndrome patients but with large variability (median, 0.79 [0.53–1.08]; range, 0.16–1.40). Our population of COVID-19 patients with ARDS confirmed that physiologic variability and need for personalized treatment are hallmarks of ARDS (21) . keywords: ards; eit; lung; patients; peep; recruitment; syndrome; ventilation cache: cord-301830-nxtfhxjd.txt plain text: cord-301830-nxtfhxjd.txt item: #147 of 227 id: cord-303101-3s9mjcf7 author: Wrigge, H. title: Spezifische Therapie des akuten Lungenversagens date: 2020-09-23 words: 2940 flesch: 40 summary: Abhängig von der Erfahrung des durchführenden Teams sind diese Maßnahmen auch bei beatmeten Patienten und auch unter Katecholamintherapie oder anderen Organersatzverfahren grundsätzlich möglich. Nach schweren Verläufen auftretende Critical-illness-Myopathie und Critical-illness-Polyneuropathie können das Weaning von der Beatmung bei COVID-19-Patienten in besonderer Weise erschweren. keywords: ards; auch; auf; bei; das; dass; der; des; die; distress; eine; ist; kann; mit; oder; patienten; peep; sich; syndrome; und; ventilation; von; werden; zur cache: cord-303101-3s9mjcf7.txt plain text: cord-303101-3s9mjcf7.txt item: #148 of 227 id: cord-303232-0lwmzjxz author: Konig, Maximilian F title: Targeting the catecholamine-cytokine axis to prevent SARS-CoV-2 cytokine storm syndrome date: 2020-04-08 words: 1450 flesch: 30 summary: Emerging evidence suggests that a subset of COVID-19 is characterized by the development of a cytokine storm syndrome (CSS) that resembles cytokine release syndrome (CRS) in chimeric antigen receptor (CAR)-T cell therapy 2, 4, 5 . In 2017, Johns Hopkins University filed a patent application on the use of various drugs to prevent cytokine release syndromes, on which V.S., R.B., B.V., K.W.K., and S.Z. are listed as inventors. . keywords: antagonists; covid-19; cytokine; patients cache: cord-303232-0lwmzjxz.txt plain text: cord-303232-0lwmzjxz.txt item: #149 of 227 id: cord-303292-iheq50ub author: De Jong, Audrey title: How to ventilate obese patients in the ICU date: 2020-10-23 words: 7499 flesch: 36 summary: an official American thoracic society clinical practice guideline Perioperative care of the obese patient Respiratory management of the obese patient undergoing surgery Mechanical ventilation in obese ICU patients: from intubation to extubation Pathophysiology of sleep apnea Cardiac arrest and mortality related to intubation procedure in critically ill adult patients: a multicenter cohort study Difficult intubation in obese patients: incidence, risk factors, and complications in the operating theatre and in intensive care units Videolaryngoscope versus Macintosh laryngoscope for tracheal intubation in adults with obesity: a systematic review and meta-analysis A multicenter, randomized trial of ramped position vs sniffing position during endotracheal intubation of critically ill adults Positive end-expiratory pressure during induction of general anesthesia increases duration of nonhypoxic apnea in morbidly obese patients Nasal high-flow preoxygenation for endotracheal intubation in the critically ill patient: a randomized clinical trial Bag-mask ventilation during tracheal intubation of critically ill adults Focus on noninvasive respiratory support before and after mechanical ventilation in patients with acute respiratory failure Prevention of atelectasis in morbidly obese patients during general anesthesia and paralysis: a computerized tomography study Protective versus conventional ventilation for surgery: a systematic review and individual patient data meta-analysis Intraoperative ventilation settings and their associations with postoperative pulmonary complications in obese patients Noninvasive monitoring of lung recruitment maneuvers in morbidly obese patients: the role of pulse oximetry and volumetric capnography Positive endexpiratory pressure optimization using electric impedance tomography in morbidly obese patients during laparoscopic gastric bypass surgery Effect of intraoperative high positive end-expiratory pressure (PEEP) with recruitment maneuvers vs low peep on postoperative pulmonary complications in obese patients: a randomized clinical trial A trial of intraoperative lowtidal-volume ventilation in abdominal surgery Spontaneous breathing with airway pressure release ventilation favors ventilation in dependent lung regions and counters cyclic alveolar collapse in oleic-acid-induced lung injury: a randomized controlled computed tomography trial NAVa In Acute respira-TORy failure (NAVIATOR) key: cord-303292-iheq50ub authors: De Jong, Audrey; Wrigge, Hermann; Hedenstierna, Goran; Gattinoni, Luciano; Chiumello, Davide; Frat, Jean-Pierre; Ball, Lorenzo; Schetz, Miet; Pickkers, Peter; Jaber, Samir title: How to ventilate obese patients in the ICU date: 2020-10-23 journal: Intensive Care Med DOI: 10.1007/s00134-020-06286-x sha: doc_id: 303292 cord_uid: iheq50ub Obesity is an important risk factor for major complications, morbidity and mortality related to intubation procedures and ventilation in the intensive care unit (ICU). keywords: airway; ards; failure; icu; lung; niv; obese; obesity; patients; peep; pressure; ventilation cache: cord-303292-iheq50ub.txt plain text: cord-303292-iheq50ub.txt item: #150 of 227 id: cord-304201-fziv9a9k author: Chiang, Chi-Huei title: Eight-Month Prospective Study of 14 Patients With Hospital-Acquired Severe Acute Respiratory Syndrome date: 2004-11-30 words: 4229 flesch: 43 summary: The mean ± SD diffusing capacity of ARDS survivors who also had SARS was reduced to 51.5%±11.0% of the predicted normal value but was 83.8%±16% of that predicted in SARS patients who did not have ARDS. Our patients experienced diarrhea more commonly than SARS patients reported in other studies. keywords: acute; chest; hospital; ldh; levels; lung; patients; sars; syndrome cache: cord-304201-fziv9a9k.txt plain text: cord-304201-fziv9a9k.txt item: #151 of 227 id: cord-305389-n5cppi72 author: D’Alonzo, Daniele title: COVID-19 and pneumonia: a role for the uPA/uPAR system date: 2020-06-18 words: 4856 flesch: 28 summary: uPAR binds vitronectin, and multiple cell receptors, such as different types of transmembrane receptor [the formyl peptide receptors (FPRs), integrins, and VEGFR2 [23] ], establishing crosstalk between membrane-bound uPAR and its co-receptors. uPAR interacts with cell membrane receptors, such as integrins, FPRs, and VEGFR2. keywords: activator; ards; cell; levels; patients; peptide; plasminogen; receptor; soluble; system; upar; uparant; urokinase cache: cord-305389-n5cppi72.txt plain text: cord-305389-n5cppi72.txt item: #152 of 227 id: cord-305703-ypeibwje author: Veronese, Nicola title: Use of Corticosteroids in Coronavirus Disease 2019 Pneumonia: A Systematic Review of the Literature date: 2020-04-24 words: 2884 flesch: 30 summary: Therefore, the clinical, therapeutic, and side effects of systemic glucocorticoid therapy in COVID-19 patients are currently unclear. When considering patients with SARS and MERS, the use of corticosteroids therapy is still debated (20, 21) . keywords: ards; corticosteroids; covid-19; patients; review; studies; use cache: cord-305703-ypeibwje.txt plain text: cord-305703-ypeibwje.txt item: #153 of 227 id: cord-305758-6twwcp47 author: Combes, Alain title: ECMO for severe ARDS: systematic review and individual patient data meta-analysis date: 2020-10-06 words: 4636 flesch: 39 summary: In conclusion, this meta-analysis of individual patient data of the CESAR and EOLIA trials showed strong evidence of a clinically meaningful benefit of early ECMO in severe ARDS patients. key: cord-305758-6twwcp47 authors: Combes, Alain; Peek, Giles J.; Hajage, David; Hardy, Pollyanna; Abrams, Darryl; Schmidt, Matthieu; Dechartres, Agnès; Elbourne, Diana title: ECMO for severe ARDS: systematic review and individual patient data meta-analysis date: 2020-10-06 journal: Intensive Care Med DOI: 10.1007/s00134-020-06248-3 sha: doc_id: 305758 cord_uid: 6twwcp47 PURPOSE: To assess the effect of venovenous extracorporeal membrane oxygenation (ECMO) compared to conventional management in patients with severe acute respiratory distress syndrome (ARDS). keywords: analysis; ards; data; ecmo; extracorporeal; failure; meta; patients; syndrome cache: cord-305758-6twwcp47.txt plain text: cord-305758-6twwcp47.txt item: #154 of 227 id: cord-306153-aurm848i author: Schenck, Edward J. title: Respiratory Mechanics and Gas Exchange in COVID-19–associated Respiratory Failure date: 2020-09-17 words: 1980 flesch: 43 summary: Patients in this cohort of COVID-19 respiratory failure meet criteria for moderate to severe ARDS, and had baseline respiratory mechanics that were comparable to those in patients enrolled in prior therapeutic trials and observational studies of ARDS. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries National Heart, Lung, and Blood Institute PETAL Clinical Trials Network. keywords: ards; covid-19; median; patients; ventilation cache: cord-306153-aurm848i.txt plain text: cord-306153-aurm848i.txt item: #155 of 227 id: cord-308402-37i62atc author: Barnes, Betsy J. title: Targeting potential drivers of COVID-19: Neutrophil extracellular traps date: 2020-04-16 words: 3927 flesch: 29 summary: Key enzymes in the formation of NETs are: neutrophil elastase (NE), which degrades intracellular proteins and triggers nuclear disintegration; peptidyl arginine deiminase type 4 (PAD4), which citrullinates histones to facilitate the decondensation and release of the chromosomal DNA; and gasdermin D, which generates pores in the membrane of the neutrophil, thereby facilitating cell membrane rupture and the expulsion of DNA and the associated molecules Kaplan and Radic, 2012; Papayannopoulos, 2018; Papayannopoulos et al., 2010; Rohrbach et al., 2012; Sollberger et al., 2018) . ; Xu et al., 2015) . keywords: ards; covid-19; disease; et al; extracellular; formation; histones; lung; nets; neutrophil; patients; traps cache: cord-308402-37i62atc.txt plain text: cord-308402-37i62atc.txt item: #156 of 227 id: cord-309089-ex9nh1yi author: Coperchini, Francesca title: The Cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system date: 2020-05-11 words: 6141 flesch: 37 summary: An interferon-gamma-related cytokine storm in SARS patients Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome Interaction of severe acute respiratory syndrome-associated coronavirus with dendritic cells Chemokine up-regulation in SARS-coronavirus-infected, monocyte-derived human dendritic cells Pathogenesis of severe acute respiratory syndrome Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome Induction of IL-8 release in lung cells via activator protein-1 by recombinant baculovirus displaying severe acute respiratory syndrome-coronavirus spike proteins: identification of two functional regions A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection Age-related increases in PGD(2) -Tumor necrosis factor α (TNFα) is a pyrogen cytokine released from immune cells in the acute phase of inflammation and infection. keywords: acute; cells; chemokines; coronavirus; cov; covid-19; cxcl10; cytokine; immune; infection; patients; sars; syndrome cache: cord-309089-ex9nh1yi.txt plain text: cord-309089-ex9nh1yi.txt item: #157 of 227 id: cord-310069-ay4af6xr author: Tobin, Martin J. title: Does making a diagnosis of ARDS in COVID-19 patients matter? date: 2020-07-21 words: 1249 flesch: 46 summary: key: cord-310069-ay4af6xr authors: Tobin, Martin J. title: Does making a diagnosis of ARDS in COVID-19 patients matter? date: 2020-07-21 journal: Chest DOI: 10.1016/j.chest.2020.07.028 sha: doc_id: 310069 cord_uid: ay4af6xr nan The question Do patients with COVID-19 develop typical ARDS? is arousing fevered debate. Other commentators consider high compliance measurements as grounds for doubting typical ARDS in COVID-19 patients. keywords: ards; covid-19; patients cache: cord-310069-ay4af6xr.txt plain text: cord-310069-ay4af6xr.txt item: #158 of 227 id: cord-310240-otf9ruvj author: Prohaska, Stefanie title: Intravenous immunoglobulin fails to improve ARDS in patients undergoing ECMO therapy date: 2018-02-26 words: 3638 flesch: 46 summary: Indeed, in a recent retrospective analysis of 543 patients, high IgG levels were associated with high mortality in sepsis patients [18] . ARDS patients suffer from severe hypoxemia, and extracorporeal membrane oxygenation (ECMO) therapy may be necessary to ensure oxygenation. keywords: ards; control; days; group; ivig; patients; therapy cache: cord-310240-otf9ruvj.txt plain text: cord-310240-otf9ruvj.txt item: #159 of 227 id: cord-315093-ifeulv55 author: Longobardo, Alessia title: Inhaled nitric oxide produces minimal improvement in oxygenation in COVID-19 related ARDS date: 2020-10-14 words: 828 flesch: 41 summary: Venous thromboembolism (VTE) was diagnosed in 7 (35%) COVID-19 patients. Baseline PaO 2 : FiO 2 ratio, dose of iNO, use of steroid, prone position ventilation, C-reactive protein, D-dimer levels, N-terminal B-type natriuretic peptide (NT-BNP) levels, fluid balance, driving pressure, days from ICU admission to iNO, pulmonary compliance, diagnosis of VTE, or body mass index did not discriminate between COVID-19 patients who responded to iNO or not (Supplementary Figure 1) . keywords: ards; covid-19; patients cache: cord-315093-ifeulv55.txt plain text: cord-315093-ifeulv55.txt item: #160 of 227 id: cord-315866-6vcts4w3 author: Chan, KC Allen title: Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study date: 2005-04-09 words: 2555 flesch: 43 summary: Here, we showed that both susceptibility and disease outcome of SARS infection were not associated with ACE I/D polymorphism among Chinese patients in contrast to the recent report studying Vietnamese patients [10] . A recent study has suggested that the deletion allele (D allele) of the angiotensin converting enzyme (ACE) gene is associated with hypoxemia in SARS patients. keywords: ace; ards; patients; polymorphism; sars cache: cord-315866-6vcts4w3.txt plain text: cord-315866-6vcts4w3.txt item: #161 of 227 id: cord-316056-lk2upygf author: Lepper, Philipp M. title: Mechanical ventilation in early COVID-19 ARDS date: 2020-11-06 words: 941 flesch: 48 summary: The present study indicates that also CARDS requires PEEP levels we are accustomed to from usual ARDS. It has been suggested that lungs in CARDS patients with high compliance are mainly open, thus PEEP could be set at lower levels and PP might not bring the desired benefits keywords: ards; peep cache: cord-316056-lk2upygf.txt plain text: cord-316056-lk2upygf.txt item: #162 of 227 id: cord-316647-jj8anf5g author: Shang, You title: Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China date: 2020-06-06 words: 13606 flesch: 35 summary: However, considering the suggestion that restrictive fluid volume management strategy should be adopted for COVID-19 patients complicated by ARDS based on the premise of sufficient tissue perfusion, we suggest CRRT initiation in severe patients within 24 h when they show rank 2 AKI under KDIGO criteria or accompanied with cytokine storm syndrome. There are still no targeted therapies for COVID-19 patients. keywords: acute; aki; ards; care; coronavirus; covid-19; covid-19 patients; disease; expert; grade; infection; lung; mortality; patients; rationale; recommendation; risk; sedation; study; syndrome; therapy; treatment; use; ventilation cache: cord-316647-jj8anf5g.txt plain text: cord-316647-jj8anf5g.txt item: #163 of 227 id: cord-316923-b81uaooh author: Luks, Andrew M. title: Reply: COVID-19 Lung Injury and “Typical” Acute Respiratory Distress Syndrome: The Danger of Presumed Equivalency date: 2020-09-17 words: 1532 flesch: 37 summary: On a broader level, the author seems to imply that all of the severe pathology in COVID-19 lung injury is related to ventilator-induced lung injury (VILI) rather than evolution of the disease. In patients randomized to the MT arm, the initial tube placement could have COVID-19 lung injury and high-altitude pulmonary edema: a false equation with dangerous implications Covid-19 in critically ill patients in the Seattle region: case series Respiratory pathophysiology of mechanically ventilated patients with COVID-19: a cohort study Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19 Post-mortem examination of COVID19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction The pulmonary vascular lesions of the adult respiratory distress syndrome COVID-19 does not lead to a typical acute respiratory distress syndrome PROSEVA Study Group. keywords: covid-19; injury; lung; patients cache: cord-316923-b81uaooh.txt plain text: cord-316923-b81uaooh.txt item: #164 of 227 id: cord-317619-o7qfugjw author: Nye, Steven title: Viral Infection in the Development and Progression of Pediatric Acute Respiratory Distress Syndrome date: 2016-11-24 words: 6739 flesch: 26 summary: implications for spread and control Evolution and ecology of influenza A viruses Adaptation of avian influenza A virus polymerase in mammals to overcome the host species barrier The pig as a mixing vessel for influenza viruses: human and veterinary implications Updating the accounts: global mortality of the 1918-1920 Spanish influenza pandemic Swine influenza a outbreak Swine influenza A (H1N1) infection in two children -Southern California Differential susceptibilities of human lung primary cells to H1N1 influenza viruses pandemic influenza A (H1N1): pathology and pathogenesis of 100 fatal cases in the United States Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico Influenza virus pathogenicity regulated by host cellular proteases, cytokines and metabolites, and its therapeutic options Three fatal cases of pandemic 2009 influenza A virus infection in Shenzhen are associated with cytokine storm Antibody and inflammatory response-mediated severity of pandemic 2009 (pH1N1) influenza virus Cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection Monocyte chemoattractant protein 1 contributes to an adequate immune response in influenza pneumonia Role of inhaled nitric oxide in the management of severe acute respiratory distress syndrome Comparison of two fluid-management strategies in acute lung injury Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome Prone positioning in severe acute respiratory distress syndrome Biological challenges and technological opportunities for respiratory syncytial virus vaccine development Phase-I study MEDI-534, of a live, attenuated intranasal vaccine against respiratory syncytial virus and parainfluenza-3 virus in seropositive children Live-attenuated respiratory syncytial virus vaccines A gene deletion that up-regulates viral gene expression yields an attenuated RSV vaccine with improved antibody responses in children Enhanced neutralizing antibody response induced by respiratory syncytial virus prefusion F protein expressed by a vaccine candidate Antibodies for prevention and treatment of respiratory syncytial virus infections in children Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virus Effectiveness of palivizumab in preventing RSV hospitalization in high risk children: a real-world perspective Comparison of intravenous palivizumab and standard of care for treatment of respiratory syncytial virus infection in mechanically ventilated pediatric patients Impact of palivizumab on admission to the ICU for respiratory syncytial virus bronchiolitis: a national survey Safety and antiviral activity of motavizumab, a respiratory syncytial virus (RSV)-specific humanized monoclonal antibody, when administered to RSV-infected children Motavizumab treatment of infants hospitalized with respiratory syncytial virus infection does not decrease viral load or severity of illness Safety and effectiveness of palivizumab in children at high risk of serious disease due to respiratory syncytial virus infection: a systematic review Serum cross-reactive antibody response to a novel influenza A (H1N1) virus after vaccination with seasonal influenza vaccine Safety and immunogenicity following administration of a live, attenuated monovalent 2009 H1N1 influenza vaccine to children and adults in two randomized controlled trials A novel influenza A (H1N1) vaccine in various age groups Pandemic vaccination strategies and influenza severe outcomes during the influenza A(H1N1)pdm09 pandemic and the post-pandemic influenza season: the Nordic experience A controlled trial of aerosolized ribavirin in infants receiving mechanical ventilation for severe respiratory syncytial virus infection Safety issues related to the administration of ribavirin Broad-spectrum antiviral activity of Virazole: 1-beta-d-ribofuranosyl-1,2,4-triazole-3-carboxamide Ribavirin for respiratory syncytial virus infection of the lower respiratory tract in infants and young children Inhaled ribavirin therapy in adult respiratory syncytial virus-induced acute respiratory distress syndrome Virological clearance rate of high-dose oseltamivir or triple-combination antiviral therapy in complicated 2009 pandemic influenza A (H1N1) infection Respiratory syncytial virus Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms Oral GS-5806 activity in a respiratory syncytial virus challenge study Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: randomized controlled trials for prevention and treatment H1N1 influenza and experience in three critical care units Systematic review of influenza resistance to the neuraminidase inhibitors Critically ill children during the 2009-2010 influenza pandemic in the United States Probability of survival after prolonged extracorporeal membrane oxygenation in pediatric patients with acute respiratory failure. While the overall incidence of respiratory virus infection, in particular RSV and influenza A (H1N1) virus, leading to lower respiratory tract disease is widely studied (12, 13), the frequency of progression to pediatric ARDS has yet to be clearly determined. keywords: ards; children; disease; h1n1; infection; influenza; patients; pediatric; rsv; severity; syncytial; treatment; virus cache: cord-317619-o7qfugjw.txt plain text: cord-317619-o7qfugjw.txt item: #165 of 227 id: cord-318067-4hdeuweo author: Torrego, Alfons title: Bronchoscopy in Patients with COVID-19 with Invasive Mechanical Ventilation: A Single-Center Experience date: 2020-07-15 words: 1887 flesch: 37 summary: Some authors have regularly reported from their clinical experience that the key feature of COVID-19 respiratory mechanics would be an uncommon association of severe hypoxemia and preserved respiratory system compliance, altogether with poor recruitability (3) (4) (5) . key: cord-318067-4hdeuweo authors: Torrego, Alfons; Pajares, Virginia; Fernández-Arias, Carmen; Vera, Paula; Mancebo, Jordi title: Bronchoscopy in Patients with COVID-19 with Invasive Mechanical Ventilation: A Single-Center Experience date: 2020-07-15 journal: Am J Respir Crit Care Med DOI: 10.1164/rccm.202004-0945le sha: doc_id: 318067 cord_uid: 4hdeuweo nan To the Editor: Severe coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to acute respiratory distress syndrome and hypoxemic respiratory failure (1) . keywords: ards; bronchoscopy; covid-19; data; patients cache: cord-318067-4hdeuweo.txt plain text: cord-318067-4hdeuweo.txt item: #166 of 227 id: cord-318209-llucxztc author: Öztürk, Selçuk title: Therapeutic Applications of Stem Cells and Extracellular Vesicles in Emergency Care: Futuristic Perspectives date: 2020-08-24 words: 13636 flesch: 29 summary: A phase-1 clinical trial investigating autologous BM-derived mononuclear cell (BM-MNC) infusion in pediatric TBI patients indicated that Fig. 1 Main pathological conditions requiring acute emergency care that can benefit from stem cell therapies or extracellular vesicle therapies in the future harvesting and infusion of stem cells is safe in children with no infusion related toxicity or death A recently published systematic review of 76 studies testing stem cells in rodent ischemic stroke models and 4 randomized human clinical trials encompassing ischemic stroke patients treated with autologous stem cells with at least one year follow-up period demonstrated that stem cell therapies show beneficial effects in terms of behavior and histological outcomes in rodents. keywords: acute; cells; effects; evs; exosomes; extracellular; human; injury; mesenchymal; mscs; patients; potential; radiation; stem; stem cells; stroke; studies; study; therapies; therapy; tissue; treatment; vesicles cache: cord-318209-llucxztc.txt plain text: cord-318209-llucxztc.txt item: #167 of 227 id: cord-321149-hffj7s4o author: Schmidt, Matthieu title: Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study date: 2020-08-13 words: 5370 flesch: 41 summary: Systemic inflammatory response syndrome is a major contributor to COVID-19-associated coagulopathy: insights from a prospective single center cohort study Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Severe pulmonary embolism in COVID-19 patients: a call for increased awareness High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study Mechanical ventilation management during extracorporeal membrane oxygenation for acute respiratory distress syndrome. Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome and posterior probability of mortality benefit in a post hoc Bayesian analysis of a randomized clinical trial Surviving sepsis campaign: guidelines on the management of critically ill adults with coronavirus disease 2019 (COVID-19) Extracorporeal life support organization coronavirus disease 2019 interim guidelines: a consensus document from an international group of interdisciplinary extracorporeal membrane oxygenation providers Preparing for the most critically ill patients with COVID-19: the potential role of extracorporeal membrane oxygenation Planning and provision of ECMO services for severe ARDS during the COVID-19 pandemic and other outbreaks of emerging infectious diseases Poor survival with extracorporeal membrane oxygenation in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19): pooled analysis of early reports Extracorporeal membrane oxygenation for coronavirus disease 2019-induced acute respiratory distress syndrome: a multicenter descriptive study COVID-19, ECMO, and lymphopenia: a word of caution Clinical management of severe acute respiratory infection when COVID-19 disease is suspected The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material Emergency circulatory support in refractory cardiogenic shock patients in remote institutions: a pilot study (the cardiac-RESCUE program) Retrieval of severe acute respiratory failure patients on extracorporeal membrane oxygenation: any impact on their outcomes? keywords: ards; care; covid-19; ecmo; extracorporeal; hospital; icu; membrane; oxygenation; patients; pressure; state cache: cord-321149-hffj7s4o.txt plain text: cord-321149-hffj7s4o.txt item: #168 of 227 id: cord-321499-17n9tj70 author: Marini, John J. title: Integrating the evidence: confronting the COVID-19 elephant date: 2020-07-25 words: 1711 flesch: 37 summary: Respiratory failure often resolves slowly in the most severely ill who do survive Which available drugs and proposed anti-viral approaches for COVID-19 treatment hold the most potential for benefit or risk? Mortality rates are higher among those with diabetes, hypertension, chronic heart or lung disease, the elderly, and the morbidly obese Can we develop an effective vaccine against variants of COVID and distribute it worldwide? keywords: ards; covid-19; distress; lung; patients cache: cord-321499-17n9tj70.txt plain text: cord-321499-17n9tj70.txt item: #169 of 227 id: cord-321878-bnjupaik author: Deliwala, Smit S. title: A 29-Year-Old Male with a Fatal Case of COVID-19 Acute Respiratory Distress Syndrome (CARDS) and Ventilator-Induced Lung Injury (VILI) date: 2020-07-23 words: 2254 flesch: 38 summary: COVID-19 patients complicated by ARDS (CARDS) can present despite lacking traditional risk factors such as advancing age, pre-existing co-morbidities, or an advanced lung pathology [5] . Post-mortem studies reveal numerous thromboses in COVID-19 patients with d-dimer serving as a surrogate marker of pulmonary endothelial damage, promoting ventilation-perfusion mismatches and subsequent hypoxemia keywords: ards; covid-19; lung; patients; pneumothorax; type; vili cache: cord-321878-bnjupaik.txt plain text: cord-321878-bnjupaik.txt item: #170 of 227 id: cord-322887-md446f9p author: Carver, Catherine title: Cardiac injury and ARDS meta-analysis validity – Correspondence in response to Santoso et al. date: 2020-06-27 words: 541 flesch: 46 summary: If so, we would appreciate Santoso et al sharing this information publicly as it would inform our research and no doubt that of others. key: cord-322887-md446f9p authors: Carver, Catherine; Jones, Nicholas title: Cardiac injury and ARDS meta-analysis validity – Correspondence in response to Santoso et al. date: 2020-06-27 journal: Am J Emerg Med DOI: 10.1016/j.ajem.2020.06.028 sha: doc_id: 322887 cord_uid: md446f9p nan In the course of writing a rapid review for the University of Oxford, we came across an interesting and timely systematic review and meta-analysis in the American Journal of Emergency Medicine by and colleagues (1). keywords: ards cache: cord-322887-md446f9p.txt plain text: cord-322887-md446f9p.txt item: #171 of 227 id: cord-323303-q0hjtsgi author: Roy, A. title: Physiological Effect of Prone Positioning in Mechanically Ventilated SARS- CoV-2 Infected Patients with Severe ARDS: Preliminary Analysis of an Observational Study date: 2020-09-18 words: 1742 flesch: 47 summary: Prone position in SARS- CoV-2 infected severe ARDS patients is associated with improvement in lung compliance and oxygenation in two- third of the patients and persisted in half of the patients. We have found that around 75% of the SARS-CoV-2 infected patients with severe ARDS responded with 16h prone position in terms of oxygenation. keywords: license; patients; position; preprint cache: cord-323303-q0hjtsgi.txt plain text: cord-323303-q0hjtsgi.txt item: #172 of 227 id: cord-323566-jck799zq author: Cheung, Oi-Yee title: Acute Lung Injury date: 2017-11-05 words: 8319 flesch: 34 summary: Other histologic features of acute lung injury include intraalveolar fibrin, organization, interstitial edema, and reactive pneumocytes. Diffuse alveolar damage and other histologic features of acute lung injury are nonspecific as to etiology, and once identified require the pathologist to search the biopsy for further features that may help identify a specific etiology. keywords: acute; alveolar; biopsy; cases; cause; dad; diffuse; disease; fig; infection; injury; lung; patients; pneumonia; pulmonary; syndrome cache: cord-323566-jck799zq.txt plain text: cord-323566-jck799zq.txt item: #173 of 227 id: cord-324232-nupi7f72 author: Villar, Jesús title: Rationale for Prolonged Corticosteroid Treatment in the Acute Respiratory Distress Syndrome Caused by Coronavirus Disease 2019 date: 2020-04-29 words: 2382 flesch: 31 summary: Recommendations for COVID-19 clinical management Treatment of severe acute respiratory syndrome with glucosteroids: The Guangzhou experience An exploratory reanalysis of the randomized trial on efficacy of corticosteroids as rescue therapy for the late phase of acute respiratory distress syndrome Second, they ignored the positive findings of two large studies (5,327 patients with severe acute respiratory syndrome [SARS] keywords: ards; corticosteroids; covid-19; patients; syndrome; treatment cache: cord-324232-nupi7f72.txt plain text: cord-324232-nupi7f72.txt item: #174 of 227 id: cord-324296-a9as72bx author: Combes, Alain title: Extracorporeal life support for adults with acute respiratory distress syndrome date: 2020-11-02 words: 6569 flesch: 31 summary: Extracorporeal CO2 removal for acute respiratory distress syndrome Efficacy and safety of lower versus higher CO2 extraction devices to allow ultraprotective ventilation: secondary analysis of the SUPERNOVA study Extracorporeal CO2 removal: the minimally invasive approach, theory, and practice Extracorporeal membrane oxygenation for pandemic influenza A(H1N1)-induced acute respiratory distress syndrome: a cohort study and propensity-matched analysis The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1) Extracorporeal membrane oxygenation for 2009 influenza A (H1N1) acute respiratory distress syndrome Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial Learning from a trial stopped by a data and safety monitoring board Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome and posterior probability of mortality benefit in a post hoc bayesian analysis of a randomized clinical trial ECMO for severe ARDS: systematic review and individual patient data meta-analysis Venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis Time for clinicians to embrace their inner bayesian? Analysis of the extracorporeal life support organization registry Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients Mortality and costs following extracorporeal membrane oxygenation in critically ill adults: a population-based cohort study Long-term outcomes of pandemic 2009 influenza A(H1N1)-associated severe ARDS Understanding ethical decisions for patients on extracorporeal life support Practice patterns and ethical considerations in the management of venovenous extracorporeal membrane oxygenation patients: an international survey Low-flow assessment of current ECMO/ECCO2R rotary blood pumps and the potential effect on hemocompatibility Feasibility and safety of ultra-low tidal volume ventilation without extracorporeal circulation in moderately severe and severe ARDS patients ECMO for immunosuppressed patients with acute respiratory distress syndrome: drawing a line in the sand Saying no until the moment is right: initiating ECMO in the EOLIA era Extracorporeal organ support: from technological tool to clinical strategy supporting severe organ failure We thank Savannah Soenen for the creation of the figures. keywords: acute; ards; blood; distress; ecmo; extracorporeal; lung; membrane; oxygenation; patients; pressure; syndrome; ventilation cache: cord-324296-a9as72bx.txt plain text: cord-324296-a9as72bx.txt item: #175 of 227 id: cord-324869-f14n0hk6 author: Khan, Hafiz Muhammad Waqas title: Unusual Early Recovery of a Critical COVID-19 Patient After Administration of Intravenous Vitamin C date: 2020-07-25 words: 2559 flesch: 44 summary: Based on the above data, vitamin C has been increasingly used recently in the treatment of COVID-19 disease, and Peng et al., from Wuhan University, initiated a phase II trial to study the efficacy of vitamin C infusion in the treatment of ARDS associated with SARS-CoV-2, in which patients receive 24 g of intravenous vitamin C per day for a total of 7 days Vitamin C infusion was not part of the treatment for COVID-19 at our institute as it has not been approved as a standard treatment for SARS-CoV-2. keywords: ards; covid-19; day; icu; patient; vitamin cache: cord-324869-f14n0hk6.txt plain text: cord-324869-f14n0hk6.txt item: #176 of 227 id: cord-325408-uy5ew3ki author: Singer, Benjamin D. title: A Call for Rational Intensive Care in the Era of COVID-19 date: 2020-07-17 words: 1614 flesch: 43 summary: We show in the present study that severe RSV infection in infants is associated with a marked upregulation of CD32 on T cells. They had no airway infections for a 4-week period before the study or any episode of severe RSV infection in their past. keywords: ards; cells; covid-19; patients; rsv; trials cache: cord-325408-uy5ew3ki.txt plain text: cord-325408-uy5ew3ki.txt item: #177 of 227 id: cord-325461-q8igdvq4 author: Ryan, Donal title: Pulmonary vascular dysfunction in ARDS date: 2014-08-22 words: 6631 flesch: 37 summary: We know from studies of major pulmonary embolism, that a normal right ventricle cannot acutely generate pulmonary pressures greater than 40 mmHg (mean) and quickly fails in this clinical context [64] . Pulmonary arterial pressure, pulmonary vascular resistance and transpulmonary gradient (TPG) depend not alone on the intrinsic properties of the pulmonary vascular bed but are also strongly influenced by cardiac output, airway pressures and lung volumes. keywords: acute; ards; lung; mortality; patients; pressure; pulmonary; resistance; right; syndrome; vascular cache: cord-325461-q8igdvq4.txt plain text: cord-325461-q8igdvq4.txt item: #178 of 227 id: cord-325755-n7vjjw9r author: Rai, Deependra Kumar title: Post covid 19 pulmonary fibrosis- Is it real threat? date: 2020-11-10 words: 2527 flesch: 41 summary: As we move forward through this pandemic, the challenging part is how to manage this COVID-19 Sequelae which may vary from mild in terms of fatigue and body aches to lung fibrosis. Elderly patient who require ICU care and mechanical ventilation are highest risk to develop lung fibrosis. keywords: covid-19; disease; fibrosis; lung; patients; post cache: cord-325755-n7vjjw9r.txt plain text: cord-325755-n7vjjw9r.txt item: #179 of 227 id: cord-326613-253v48i0 author: Lv, Dandan title: A novel cell-based assay for dynamically detecting neutrophil extracellular traps-induced lung epithelial injuries date: 2020-05-29 words: 1088 flesch: 35 summary: However, the direct visualization of lung epithelial injuries caused by NETs, and the qualitative and quantitative evaluations of this damage are still lacking. Our results demonstrated that lung epithelial injuries, reflected by declines in cell index (CI) values, could be induced by lipopolysaccharide (LPS)-activated PMNs, or NETs in a time and dose-dependent manner. keywords: cell; lung; nets; pmns cache: cord-326613-253v48i0.txt plain text: cord-326613-253v48i0.txt item: #180 of 227 id: cord-326805-c5co9cfq author: Lin, Shi-hui title: Coronavirus Disease 2019 (COVID-19): Cytokine Storms, Hyper-Inflammatory Phenotypes, and Acute Respiratory Distress Syndrome date: 2020-06-29 words: 1366 flesch: 33 summary: [42] Subphenotypes 35 with higher Ang-2 levels, which are characterized by higher inflammatory biomarkers and 1 hypotension, may reflect more endothelial permeability and predilection for extravascular fluid 2 accumulation that responds favorably to fluid restriction. Finally, we explore the possibility of improving the quality of monitoring and treatment of COVID-19 patients and in reducing the incidence of critical illness and mortality via better distinguishing hyper- and hypo-inflammatory subphenotypes of COVID-19. keywords: ards; covid-19; hyper; patients; syndrome cache: cord-326805-c5co9cfq.txt plain text: cord-326805-c5co9cfq.txt item: #181 of 227 id: cord-326874-rdwvsm4s author: Wu, Chaomin title: Corticosteroid therapy for coronavirus disease 2019-related acute respiratory distress syndrome: a cohort study with propensity score analysis date: 2020-11-10 words: 4472 flesch: 31 summary: In this clinical practice setting, low-dose corticosteroid treatment was associated with reduced risk of in-hospital death within 60 days in COVID-19 patients who developed ARDS. [7] , and has been widely used by clinicians to suppression of hyperinflammation in COVID-19 patients, especially those with critical illness keywords: ards; corticosteroids; covid-19; days; hospital; patients; score; treatment cache: cord-326874-rdwvsm4s.txt plain text: cord-326874-rdwvsm4s.txt item: #182 of 227 id: cord-328396-p2gvpe8i author: Kaur, Savneet title: The Enigma of Endothelium in COVID-19 date: 2020-08-04 words: 4441 flesch: 30 summary: Lung pathology from COVID-19 patients has depicted that along with pulmonary type 2 alveolar epithelial cells, endothelial cells in the systemic venules are also desquamated and an inflammatory reaction is present in blood vessel walls (vasculitis), suggestive of intense vascular reactions (Ding et al., 2003) . Lung autopsies from COVID-19 patients also show massive neutrophil infiltration in pulmonary capillaries, acute capillaritis and extravasation of neutrophils into the alveolar space (Fox et al., 2020; Liu et al., 2020) . keywords: cells; cov-2; covid-19; endothelial; et al; injury; patients; pulmonary; sars cache: cord-328396-p2gvpe8i.txt plain text: cord-328396-p2gvpe8i.txt item: #183 of 227 id: cord-328569-1lx3fkv3 author: Bagate, François title: Rescue therapy with inhaled nitric oxide and almitrine in COVID-19 patients with severe acute respiratory distress syndrome date: 2020-11-04 words: 3769 flesch: 44 summary: During the first SARS-CoV outbreak in 2004, a pilot study reported the efficacy of iNO in a limited series of severe patients, with reversal of pulmonary hypertension, improved hypoxemia and shortened duration of mechanical ventilation [20] . The NO Almitrine Study Group Inhaled nitric oxide and vasoconstrictors in acute respiratory distress syndrome Additive effect on gas exchange of inhaled nitric oxide and intravenous almitrine bismesylate in the adult respiratory distress syndrome Acute respiratory distress syndrome: the Berlin Definition Formal guidelines: management of acute respiratory distress syndrome Efficacy of prone position in acute respiratory distress syndrome patients: A pathophysiology-based review Potential for lung recruitment estimated by the recruitment-toinflation ratio in acute respiratory distress syndrome a clinical trial Prevalence and prognosis of cor pulmonale during protective ventilation for acute respiratory distress syndrome Prevalence and prognosis of shunting across patent foramen ovale during acute respiratory distress syndrome The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. keywords: acute; almitrine; ards; covid-19; distress; ino; patients; pulmonary; study; syndrome cache: cord-328569-1lx3fkv3.txt plain text: cord-328569-1lx3fkv3.txt item: #184 of 227 id: cord-328996-3sf2i45r author: Barthélémy, Romain title: Efficacy of Almitrine in The Treatment of Hypoxemia in Sars-Cov-2 Acute Respiratory Distress Syndrome date: 2020-06-06 words: 1162 flesch: 50 summary: Altogether, we believe that almitrine should be evaluated in clinical trials 89 aiming at improving patient centered outcome for Covid-19 patients. 23 Inclusion criteria in the study were: admission for respiratory failure, a diagnosis of ARDS 24 according to Berlin criteria 8 , laboratory confirmed Sars-Cov-2 infection, almitrine infusion in 25 ICU. keywords: almitrine; ards; patients; sars cache: cord-328996-3sf2i45r.txt plain text: cord-328996-3sf2i45r.txt item: #185 of 227 id: cord-329381-uwae8738 author: Evrard, Bruno title: Cardiovascular phenotypes in ventilated patients with COVID-19 acute respiratory distress syndrome date: 2020-05-18 words: 542 flesch: 23 summary: The higher prevalence of LV failure and lower cardiac index in patients with flu-related ARDS is presumably related to septic cardiomyopathy since they sustained associated septic shock more frequently than COVID-19 patients. COVID-19 patients with ACP tended to have lower respiratory-system compliance than their counterparts, presumably due to distinct ARDS phenotypes [6] . keywords: ards; patients; pressure cache: cord-329381-uwae8738.txt plain text: cord-329381-uwae8738.txt item: #186 of 227 id: cord-329585-uyze6dtu author: Earhart, Alexander P. title: Consideration of dornase alfa for the treatment of severe COVID-19 ARDS date: 2020-04-30 words: 722 flesch: 31 summary: key: cord-329585-uyze6dtu authors: Earhart, Alexander P.; Holliday, Zachary M.; Hofmann, Hunter V.; Schrum, Adam G. title: Consideration of dornase alfa for the treatment of severe COVID-19 ARDS date: 2020-04-30 journal: New Microbes New Infect DOI: 10.1016/j.nmni.2020.100689 sha: doc_id: 329585 cord_uid: uyze6dtu nan where it can lead to mucus plug clearance and accelerated recovery in humans and mice (2, 3) . A controlled clinical trial for treating ARDS with dornase alfa is currently underway (4). keywords: alfa; covid-19; dornase cache: cord-329585-uyze6dtu.txt plain text: cord-329585-uyze6dtu.txt item: #187 of 227 id: cord-329985-5rji08p7 author: Robba, Chiara title: Distinct phenotypes require distinct respiratory management strategies in severe COVID-19 date: 2020-05-11 words: 4384 flesch: 35 summary: The experience in COVID-19 patients from Wuhan was similar, with a high rate of noninvasive support failure and need for intubation and mechanical ventilation in 76% of cases; nevertheless, there was no difference in mortality between patients receiving noninvasive vs invasive ventilation . Continuous infusion of neuromuscular blocking agents (NMBA) should be reserved for COVID-19 patients in which intermittent dosing may not suffice, such as: patients undergoing prone positioning, persistent ventilator asynchrony, and those with high plateau pressures (Alhazzani et al., 2013) . keywords: chest; covid-19; failure; patients; ventilation cache: cord-329985-5rji08p7.txt plain text: cord-329985-5rji08p7.txt item: #188 of 227 id: cord-330257-fliudtls author: Singh, Gurmeet title: Commentary: Protecting the Right Ventricle in COVID-19 ARDS - More Data Required date: 2020-07-16 words: 313 flesch: 42 summary: Experts' opinion on management of 54 hemodynamics in ARDS patients: focus on the effects of mechanical ventilation Acute Respiratory Distress Syndrome Extracorporeal Membrane Oxygenation for 60 Severe Acute Respiratory Distress Syndrome and Posterior Probability of Mortality Benefit 61 in a Post Hoc Bayesian Analysis of a Randomized Clinical Trial As Dr. Joyce says: Anecdotal evidence should always be viewed with a degree of skepticism. keywords: oxy cache: cord-330257-fliudtls.txt plain text: cord-330257-fliudtls.txt item: #189 of 227 id: cord-330640-6ityxc64 author: Gupta, Ashim title: Mesenchymal stem cells and exosome therapy for COVID-19: current status and future perspective date: 2020-08-11 words: 5166 flesch: 33 summary: pneumonia Treatment of acute respiratory distress syndrome with allogeneic adiposederived mesenchymal stem cells: a randomized, placebo-controlled pilot study Immunomodulatory effect of mesenchymal stem cells in chemical-induced liver injury: a high-dimensional analysis Significantly enhanced recovery of acute liver failure by liver targeted delivery of stem cells via heparin functionalization Mesenchymal stem cells increase expression of heme oxygenase-1 leading to anti-inflammatory activity in treatment of acute liver failure Mesenchymal stem cell treatment attenuates liver and lung inflammation after ethanol intoxication and burn injury Extracellular vesicles: novel mediators of cell communication in metabolic disease Immune regulatory targets ofmesenchymal stromal cell exosomes/ small extracellular vesicles in tissue regeneration Exosomes: Looking back three decades and into the future Exosomes: biogenesis, biologic function and clinical potential Mesenchymal stem cell-derived extracellular vesicles for the treatment of acute respiratory distress syndrome: Concise review Review article mesenchymal stem cellbased immunomodulation: properties and clinical application Therapeutic use of extracellular vesicles for acute and chronic lung disease Exosomal microRNAs derived from umbilical mesenchymal stem cells inhibit hepatitis C virus infection The biology of extracellular vesicles: The known unknowns Advances in analysis of biodistribution of exosomes by molecular imaging Emerging potential of exosomes for treatment of traumatic brain injury mechanisms underlying cell therapy for TBI MSC-derived exosome as a novel therapy for TBI Mesenchymal stem cell derived extracellular vesicles ameliorate kidney injury in aristolochic acid nephropathy Exosomes in respiratory disease Mesenchymal stem cell-derived extracellular vesicles attenuate influenza virusinduced acute lung injury in a pig model Conflict of interest The authors declare that they have no conflict of interest. Stem cell -based therapy for coronavirus disease 2019 Transplantation of ACE2 -Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia Primer cytokine storms: understanding COVID-19 The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID -19 infection: the contribution of inlame -aging Care for Critically Ill Patients With COVID-19 Mesenchymal stem cells in the fight against viruses: face to face with the invisible enemy Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area Bioinspired engineering for liver tissue regeneration and development of bioartificial liver: A review Stem cell therapy: a hope business or a magic wand? Mesenchymal stem cells modulate the immune system in developing therapeutic interventions Human umbilical cord-derived mesenchymal stem cells in acute liver injury: hepatoprotective efficacy, subchronic toxicity, tumorigenicity, and biodistribution Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial Regenerative abilities of mesenchymal stem cells through mitochondrial transfer Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells Typical' acute respiratory distress syndrome Immunosuppressive properties of mesenchymal stem cells: advances and applications Immunomodulation by mesenchymal stem cells and clinical experience Current status of potential therapeutic candidates for the COVID-19 crisis Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2 -dependent regulatory dendritic cell population Neoplastic differentiation: interaction of simian virus 40 and polyoma virus with murine teratocarcinoma Neither human immunodeficiency virus-1 (HIV-1) nor HIV-2 infects most-primitive human hematopoietic stem cells as assessed in long-term bone marrow cultures Ex vivo virotherapy with myxoma virus does not impair hematopoietic stem and progenitor cells Embryonic stem cells use ZFP809 to silence retroviral DNAs Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA IFITM-family proteins: the cell's first line of antiviral defense charles Stem cells intrinsic immunity shapes viral resistance of stem cells Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo Activation of human mesenchymal stem cells impacts their therapeutic abilities in lung injury by increasing interleukin ( IL ) -10 and IL-1RN levels Mesenchymal stem cells reconditioned in their own serum exhibit augmented therapeutic properties in the setting of acute respiratory distress syndrome Clinical study of mesenchymal stem cell treating acute respiratory distress syndrome induced by epidemic Inluenza A (H7N9) infection: A hint for COVID-19 treatment. keywords: acute; ards; cells; covid-19; exosomes; mesenchymal; mscs; patients; stem; studies; treatment cache: cord-330640-6ityxc64.txt plain text: cord-330640-6ityxc64.txt item: #190 of 227 id: cord-330919-dep3v1pt author: Whyte, Claire S title: Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID‐19 date: 2020-04-23 words: 4261 flesch: 30 summary: A Case Series Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism Tissue plasminogen activator (tPA) inhibits interleukin-1 induced acute lung leak Heuze-Vourc'h N. Designing inhaled protein therapeutics for topical lung delivery: what are the next steps? Effects of nebulized antithrombin and heparin on inflammatory and coagulation alterations in an acute lung injury model in rats Aerosolized anticoagulants ameliorate acute lung injury in sheep after exposure to burn and smoke inhalation Heparin nebulization attenuates acute lung injury in sepsis following smoke inhalation in sheep Nebulized anticoagulants in lung injury in critically ill patients-an updated systematic review of preclinical and clinical studies Streptokinase Versus Unfractionated Heparin Nebulization in Patients With Severe Acute Respiratory Distress Syndrome (ARDS): PAR signalling can enhance inflammation in acute lung injury (ALI) by increasing the expression of pro-inflammatory cytokines, including IL-6 keywords: acute; ards; covid-19; distress; fibrin; injury; lung; patients; plasminogen; syndrome cache: cord-330919-dep3v1pt.txt plain text: cord-330919-dep3v1pt.txt item: #191 of 227 id: cord-331500-l3hkn2li author: Luyt, Charles-Edouard title: Pulmonary infections complicating ARDS date: 2020-11-11 words: 7549 flesch: 20 summary: However, some preventive measures deserve a special focus in the context of ARDS patients (Fig. 6) : (1) oral care with chlorhexidine is suspected to worsen respiratory failure; (2) selective digestive decontamination (SDD) deserves to be discussed in such high-risk patients, as it has been proven to be effective in reducing mortality in ICU patients and likely lowers VAP rates. Acute respiratory distress syndrome Changes in prevalence of health care-associated infections in US Hospitals Ventilator-associated pneumonia and ICU mortality in severe ARDS patients ventilated according to a lung-protective strategy Ventilator-associated pneumonia in ARDS patients: the impact of prone positioning. keywords: acute; ards; care; ecmo; icu; infection; lung; patients; pneumonia; pulmonary; risk; syndrome; trial; vap; ventilator cache: cord-331500-l3hkn2li.txt plain text: cord-331500-l3hkn2li.txt item: #192 of 227 id: cord-332592-bfqsyiyf author: Goette, Andreas title: COVID-19-Induced Cytokine Release Syndrome Associated with Pulmonary Vein Thromboses, Atrial Cardiomyopathy, and Arterial Intima Inflammation date: 2020-09-26 words: 3547 flesch: 33 summary: A report of COVID-19 patients in China found elevated plasma concentrations of inflammatory markers in particular in patients with severe infections. Current concepts in the diagnosis and management of cytokine release syndrome Cytokine release from human peripheral blood leucocytes incubated with endotoxin with and without prior infection with influenza virus: relevance to the sudden infant death syndrome Porcine reproductive and respiratory syndrome virus infection triggers HMGB1 release to promote inflammatory cytokine production COVID-19: a new virus, but a familiar receptor and cytokine release syndrome Cytokine release syndrome in severe COVID-19 Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality Postmortem examination of patients with COVID-19 ECMO for ARDS due to COVID-19 The ABO blood group locus and a chromosome 3 gene cluster associate with SARS CoV-2 respiratory failure in an Italian-Spanish genome-wide association analysis Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome Activated clotting factor X mediates mitochondrial alterations and inflammatory responses via protease-activated receptor signaling in alveolar epithelial cells Will complement inhibition be the new target in treating COVID-19-related systemic thrombosis? keywords: cov-2; covid-19; fig; patients; present; pulmonary; sars; syndrome cache: cord-332592-bfqsyiyf.txt plain text: cord-332592-bfqsyiyf.txt item: #193 of 227 id: cord-333520-v2sb90rc author: Gardin, Chiara title: Could Mesenchymal Stem Cell-Derived Exosomes Be a Therapeutic Option for Critically Ill COVID-19 Patients? date: 2020-08-26 words: 10167 flesch: 29 summary: Several studies agree that reduced fibrosis and apoptosis of myocardial cells are other important effects of the EV-mediated ischemic cardiac repair Evidence from meta-analysis Cardiovascular disease and COVID-19 Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Inside the heart of COVID-19 Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study Clinical Characteristics of Coronavirus Disease 2019 in China COVID-19 and the cardiovascular system Mesenchymal stem cells and management of COVID-19 pneumonia Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury On the use of corticosteroids for 2019-nCoV pneumonia Coronaviruses and the cardiovascular system: Acute and long-term implications Treatment for emerging viruses: Convalescent plasma and COVID-19 Recommendations for Investigational COVID-19 Convalescent Plasma Chinese Clinical Trial Registry Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease: A Viewpoint on the Potential Influence of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on Onset and Severity of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. keywords: acute; cardiac; cells; covid-19; disease; effects; evs; exosomes; human; inflammatory; injury; lung; mesenchymal; msc; mscs; mvs; patients; sars; stem cache: cord-333520-v2sb90rc.txt plain text: cord-333520-v2sb90rc.txt item: #194 of 227 id: cord-333856-ujnhjy0s author: Baer, Brandon title: Exogenous Surfactant as a Pulmonary Delivery Vehicle for Budesonide In Vivo date: 2020-10-26 words: 4224 flesch: 35 summary: To improve the pulmonary distribution of glucocorticoids, such as budesonide to distal regions of the lung, exogenous surfactant has been proposed as an ideal delivery vehicle for such therapies. Based on these findings, it was concluded that exogenous surfactant can enhance the delivery and efficacy of budesonide in vivo. keywords: bles; budesonide; delivery; hkb; inflammation; instillation; lung; surfactant; treatment cache: cord-333856-ujnhjy0s.txt plain text: cord-333856-ujnhjy0s.txt item: #195 of 227 id: cord-334528-xenq90xj author: Chen, Hsing I title: Acute lung injury and acute respiratory distress syndrome: experimental and clinical investigations date: 2011-03-17 words: 5315 flesch: 29 summary: I. Light microscopy Ventilator-induced lung injury Cellular stress failure in ventilator-injured lungs Acute respiratory distress syndrome: a historical perspective The acute respiratory distress syndrome Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management Leukocyte elastase: physiological functions and role in acute lung injury Roles of neutrophil elastase and superoxide anion in leukotriene B4-induced lung injury in rabbit Chemokines in acute respiratory distress syndrome Transcriptional mechanisms of acute lung injury Alveolar epithelial fluid transport in acute lung injury: new insights Mechanisms of pulmonary edema clearance Perspective on lung injury and recruitment: a skeptical look at the opening and collapse story Critical care in AJRCCM Alveolar recruitment in acute lung injury Prone position augments recruitment and prevents alveolar overinflation in acute lung injury Hypercapnic acidosis attenuates endotoxin-induced acute lung injury Protective effects of hypercapnic acidosis on ventilator-induced lung injury Permissive hypercapnia: role in protective lung ventilatory strategies Hypercapnia via reduced rate and tidal volume contributes to lipopolysaccharide-induced lung injury Permissive hypercapnia impairs pulmonary gas exchange in the acute respiratory distress syndrome Nonventilatory treatments for acute lung injury and ARDS Ventilatory management of acute lung injury and acute respiratory distress syndrome Acute respiratory distress syndrome: pharmacological treatment options in development Pathophysiology and pharmacological treatment of pulmonary hypertension in acute respiratory distress syndrome Inhaled nitric oxide therapy in adults Exercise training attenuates septic responses in conscious rats Vascular endothelial growth factor and related molecules in acute lung injury Angiotensin-converting enzyme 2 protects from severe acute lung failure Insulin attenuates endotoxin-induced acute lung injury in conscious rats Comparison of propofol and midazolam for sedation in critically ill patients An update of its use in anaesthesia and conscious sedation The reduction of tumor necrosis factor-alpha release and tissue damage by pentobarbital in the experimental endotoxemia model N-acetylcysteine ameliorates lipopolysaccharide-induced organ damage in conscious rats Post-treatment with N-acetylcysteine ameliorates endotoxin shock-induced organ damage in conscious rats N-Acetylcysteine treatment to prevent the progression of multisystem organ failure: a prospective, randomized, placebo-controlled study Antioxidant supplementation in sepsis and systemic inflammatory response syndrome N-acetylcysteine as the magic bullet: too good to be true Experimental studies and clinical investigations were supported in part by grants from the National Science Council. [77, 78] Intratracheal instillation of hydrochloric acid (HCI) or gastric particles has been employed as experimental model of acute lung injury (ALI). keywords: acid; acute; ali; ards; distress; injury; inos; lung; nitric; oxide; pulmonary; rats; syndrome cache: cord-334528-xenq90xj.txt plain text: cord-334528-xenq90xj.txt item: #196 of 227 id: cord-335975-m6lkrehi author: None title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 words: 89523 flesch: 50 summary: The aim of this study was to compare the outcome of ICU patients having received carbapenems to those having received a carbapenem-sparing agent (CSA). Conclusion: Severe hypoxemia, independently from ARDS, worsens the prognosis of ICU patients. keywords: acute; admission; age; aim; analysis; antibiotic; ards patients; blood; brain; cardiac; care; cases; characteristics; children; clinical; conclusion; criteria; data; days; death; diagnosis; disease; drug; duration; factors; failure; fig; group; high; hospital; icu; icu admission; icu mortality; icu patients; impact; incidence; increase; infection; intensive; introduction; intubation; january; length; level; low; management; mean; median; medical; methods; min; mortality; n =; niv; non; outcome; p =; patients; period; pneumonia; post; pressure; prognosis; rate; respiratory; results; resuscitation; risk; score; sepsis; septic; severity; shock; shock patients; stay; studies; study; study period; therapy; time; treatment; unit; use; vap; ventilation; volume; vs.; years cache: cord-335975-m6lkrehi.txt plain text: cord-335975-m6lkrehi.txt item: #197 of 227 id: cord-335977-f00758o2 author: Martin-Loeches, I. title: Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection date: 2010-11-24 words: 4307 flesch: 35 summary: key: cord-335977-f00758o2 authors: Martin-Loeches, I.; Lisboa, T.; Rhodes, A.; Moreno, R. P.; Silva, E.; Sprung, C.; Chiche, J. D.; Barahona, D.; Villabon, M.; Balasini, C.; Pearse, R. M.; Matos, R.; Rello, J. title: Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection date: 2010-11-24 journal: Intensive Care Med DOI: 10.1007/s00134-010-2078-z sha: doc_id: 335977 cord_uid: f00758o2 INTRODUCTION: The main objective of this study is therefore to assess the effect on survival of early corticosteroid therapy compared with those who did not receive corticosteroids or received them subsequently as rescue therapy, in a cohort of patients hospitalized with severe presentation of pandemic (H1N1)v influenza A infection in the ICU. keywords: acute; admission; corticosteroid; hospital; icu; infection; influenza; pandemic; patients; pneumonia; therapy; use cache: cord-335977-f00758o2.txt plain text: cord-335977-f00758o2.txt item: #198 of 227 id: cord-336159-w646qkjz author: Chen, Wei title: Incidence and Outcomes of Acute Respiratory Distress Syndrome: A Nationwide Registry-Based Study in Taiwan, 1997 to 2011 date: 2015-10-30 words: 3584 flesch: 46 summary: An attempt to validate the modification of the American-European consensus definition of acute lung injury/acute respiratory distress syndrome by the Berlin definition in a university hospital Race and gender differences in acute respiratory distress syndrome deaths in the United States: an analysis of multiple-cause mortality data (1979-1996) Alveolar fluid clearance is faster in women with acute lung injury compared to men Cigarette smoke exposure and the acute respiratory distress syndrome Active and passive cigarette smoking and acute lung injury after severe blunt trauma Smoking behaviour in Taiwan The acute respiratory distress syndrome Epidemiology of acute lung injury and acute respiratory distress syndrome Mortality rates for patients with acute lung injury/ARDS have decreased over time Eight-year trend of acute respiratory distress syndrome: a population-based study in Olmsted County, Minnesota Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983-1993 Acute respiratory distress syndrome: epidemiology and management approaches The Acute Respiratory Distress Syndrome Network. Definitions, mechanisms, relevant outcomes, and clinical trial coordination The acute respiratory distress syndrome Incidence and outcomes of acute lung injury Clinical epidemiology of acute lung injury and acute respiratory distress syndrome: incidence, diagnosis, and outcomes Impact of distinct definitions of acute lung injury on its incidence and outcomes in Brazilian ICUs: prospective evaluation of 7,133 patients One-year outcomes in survivors of the acute respiratory distress syndrome Functional disability 5 years after acute respiratory distress syndrome Adult respiratory distress syndrome: a systemic overview of incidence and risk factors Incidence of the adult respiratory distress syndrome in the state of Utah Adult respiratory distress syndrome: how many cases in the UK? Incidence, severity, and mortality of acute respiratory failure in Incidence and mortality after acute respiratory failure and acute respiratory distress syndrome in Sweden, Denmark, and Iceland. keywords: acute; ards; incidence; mortality; study; syndrome; years cache: cord-336159-w646qkjz.txt plain text: cord-336159-w646qkjz.txt item: #199 of 227 id: cord-337010-dgy7qbl5 author: Tomazini, B. M. title: COVID-19-associated ARDS treated with DEXamethasone (CoDEX): Study design and rationale for a randomized trial. date: 2020-06-26 words: 5125 flesch: 42 summary: Also, due to the lack of data about ventilator free days in COVID-19 patients, the sample size will be updated using the pooled standard deviation of ventilator free days of the first interim analysis, unless by the time of the first interim analysis all patients have been recruited. Unidentified patient data will be collected through an electronic online data capture tool (REDCap) 22 23 . keywords: ards; covid-19; data; days; license; medrxiv; medrxiv preprint; patients; preprint; trial; use cache: cord-337010-dgy7qbl5.txt plain text: cord-337010-dgy7qbl5.txt item: #200 of 227 id: cord-338319-9v8yw2pl author: Trahtemberg, Uriel title: What have we learned ventilating COVID-19 patients? date: 2020-10-12 words: 1186 flesch: 32 summary: It has been suggested that prone positioning should be minimized in COVID-19 ARDS patients with higher compliances, based on the argument that the putative different respiratory physiology makes prone ventilation unlikely to be beneficial [5] . However, although there is great heterogeneity, COVID-19 ARDS patients appear to have similar recruitability [7] . keywords: ards; covid-19; patients cache: cord-338319-9v8yw2pl.txt plain text: cord-338319-9v8yw2pl.txt item: #201 of 227 id: cord-339128-npfoircv author: Blair, Robert V. title: Acute Respiratory Distress in Aged, SARS-CoV-2 Infected African Green Monkeys but not Rhesus Macaques date: 2020-11-07 words: 3101 flesch: 39 summary: However, a small subset progress to develop severe respiratory disease which, in some cases, is fatal 1 . Animal models of SARS-CoV-2 infection that manifest severe disease are needed to investigate the pathogenesis of COVID-19 induced ARDS and evaluate therapeutic strategies. keywords: agms; animals; ards; covid-19; disease; infection; sars cache: cord-339128-npfoircv.txt plain text: cord-339128-npfoircv.txt item: #202 of 227 id: cord-339293-7ks3bopm author: Nejatifard, Marzieh title: Probable Positive Effects of the Photobiomodulation as an Adjunctive Treatment in COVID-19: A Systematic Review date: 2020-10-12 words: 4588 flesch: 47 summary: Previous studies have shown the advantages of the PBM including anti-inflammatory effects and acceleration of the wound healing (10) . Keywords included the PBM and related terms, lung inflammation, and COVID-19 -related signs. keywords: ards; covid-19; disease; effects; inflammation; laser; lung; papers; patients; pbm cache: cord-339293-7ks3bopm.txt plain text: cord-339293-7ks3bopm.txt item: #203 of 227 id: cord-341063-3rqnu5bu author: None title: 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018 date: 2018-03-29 words: 98736 flesch: 48 summary: Since altered liver function has also been described in ICU patients without sepsis [1, 2] , the influence of sepsis may be overestimated. The aim of this work is to analyze the connection between serum and fecal levels of AMM in ICU patients. keywords: acute; admission; adult patients; age; aim; aki; analysis; ards; arrest; assessment; baseline; blood; brain; cardiac; care; care patients; care unit; cases; changes; clinical; cohort; complications; conclusions; control; correlation; criteria; critical; data; day mortality; days; decrease; diagnosis; difference; discharge; duration; dysfunction; early; effect; emergency; end; factors; failure; fig; flow; fluid; following; group; hospital; hospital mortality; hours; icu admission; icu mortality; icu patients; icu stay; impact; incidence; increase; infection; injury; introduction; length; levels; lung; mean; median; medical; methods; min; model; months; mortality; non; organ; outcome; p<0.001; parameters; patients; period; population; post; pressure; protocol; rate; renal; results; risk; risk patients; score; sepsis; septic; severity; shock; significant; sofa; stay; studies; study; support; surgery; surgery patients; survival; survivors; table; test; therapy; time; total; transfusion; treatment; unit; use; value; ventilation; volume; years cache: cord-341063-3rqnu5bu.txt plain text: cord-341063-3rqnu5bu.txt item: #204 of 227 id: cord-341472-29opvzrj author: Curley, Gerard F. title: Future therapies for ARDS date: 2014-12-04 words: 1550 flesch: 31 summary: Results from pre-clinical studies suggest that intra-tracheal KGF reduces lung injury induced by hyperoxia, ventilator-induced lung injury, and bacterial pneumonia. In pre-clinical studies, heparin has been found to reduce alveolar fibrin deposition and exert anti-inflammatory effects. keywords: ards; cells; injury; lung; study cache: cord-341472-29opvzrj.txt plain text: cord-341472-29opvzrj.txt item: #205 of 227 id: cord-343743-6k3soh1l author: Chaudhary, Sachin title: Antifibrotics in COVID-19 Lung Disease: Let Us Stay Focused date: 2020-09-09 words: 3353 flesch: 34 summary: Health Qual Life Outcomes Correlation between pneumonia severity and pulmonary complications in middle east respiratory syndrome Follow-up chest radiographic findings in patients with MERS-CoV after recovery Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection -clinicopathological and ultrastructural study The 1-year impact of severe acute respiratory syndrome on pulmonary function, exercise capacity, and quality of life in a cohort of survivors The longterm impact of severe acute respiratory syndrome on pulmonary function, exercise capacity and health status Follow-up study on pulmonary function and lung radiographic changes in rehabilitating severe acute respiratory syndrome patients after discharge Pulmonary sequelae in convalescent patients after severe acute respiratory syndrome: evaluation with thin-section CT Long-term bone and lung consequences associated with hospital-acquired severe acute respiratory syndrome: a 15-year follow-up from a prospective cohort study Pathology and pathogenesis of severe acute respiratory syndrome Abnormal pulmonary function in COVID-19 patients at time of hospital discharge Clinical features of patients infected with 2019 novel coronavirus in Wuhan COVID-19 pneumonia: different respiratory treatments for different phenotypes? Now, months since the initial description in Wuhan, China, with almost 10 million infected worldwide and about half a million deaths, the clinical and the scientific communities have learned much and pivoted to high-quality evidence for the management of COVID-19 patients. keywords: ards; covid-19; fibrosis; lung; patients; pulmonary; survivors; syndrome cache: cord-343743-6k3soh1l.txt plain text: cord-343743-6k3soh1l.txt item: #206 of 227 id: cord-343940-fdnmeuh8 author: Tzotzos, Susan J. title: Incidence of ARDS and outcomes in hospitalized patients with COVID-19: a global literature survey date: 2020-08-21 words: 655 flesch: 33 summary: The mortality rate of ICU COVID-19 patients is 40% and of those who receive IMV 59%; the mortality rate in COVID-19-associated ARDS is 45%, and the incidence of ARDS among non-survivors of COVID-19 is 90% ( Table 2 ). Calculation of weighted averages for these parameters incorporating data from individual studies for which data is available indicate that among hospitalized COVID-19 patients, approximately 1/3 (33%) develop ARDS, 1/4 (26%) require transfer to Patient numbers for Chen T study not included an ICU, 1/6 (16%) receive IMV, and 1/6 (16%) die (Table 1 ). keywords: covid-19; patients cache: cord-343940-fdnmeuh8.txt plain text: cord-343940-fdnmeuh8.txt item: #207 of 227 id: cord-344061-gsl84nv6 author: Pariani, Elena title: Influenza and Other Respiratory Viruses Involved in Severe Acute Respiratory Disease in Northern Italy during the Pandemic and Postpandemic Period (2009–2011) date: 2014-06-12 words: 2090 flesch: 34 summary: The proportion of SARI/ARDS cases associated with respiratory viruses other than A(H1N1)pdm09 was significantly lower (19.4% versus 58.3%, value <0.0000001). Severe respiratory diseases associated with respiratory viruses other than A(H1N1)pdm09 were detected more frequently among children ≤ 5 years (13.3% versus 30%, value = 0.02). keywords: ards; cases; influenza; sari; years cache: cord-344061-gsl84nv6.txt plain text: cord-344061-gsl84nv6.txt item: #208 of 227 id: cord-344829-adlp2rjy author: de Rivero Vaccari, Juan Carlos title: The Inflammasome in Times of COVID-19 date: 2020-10-08 words: 8734 flesch: 27 summary: Ionic imbalance has been associated with inflammasome activation in the lung following infections (64) , and consistent with this finding is a recent study by Nieto-Torres et al. showing that E protein from SARS-CoV makes a Ca 2+ permeable channel in the endoplasmic reticulum (ER)/Golgi intermediate compartment (ERGIC)/Golgi membrane that results in NLRP3 inflammasome activation and increased levels of IL-1β (Figure 3 ) (46). However, in regards to inflammasome activation, it seems that ORF3a promotes NLRP3 inflammasome activation by modulating the ubiquitination of the inflammasome adaptor protein ASC and the production of pro-IL-1β by activation of NF-κB, which is independent of the ion-channel role that ORF3a plays. keywords: activation; acute; covid-19; il-1β; infections; inflammasome; inflammatory; injury; levels; lung; nlrp3; patients; pneumonia; protein; response; role; sars; syndrome cache: cord-344829-adlp2rjy.txt plain text: cord-344829-adlp2rjy.txt item: #209 of 227 id: cord-344978-m672rnze author: Chen, Yuntian title: A Quantitative and Radiomics approach to monitoring ARDS in COVID-19 patients based on chest CT: a retrospective cohort study date: 2020-07-06 words: 3968 flesch: 44 summary: Acute respiratory distress syndrome (ARDS) is the major cause of severe cases, and early detection and early treatment of ARDS patients could improve the outcome [9, 10] . key: cord-344978-m672rnze authors: Chen, Yuntian; Wang, Yi; Zhang, Yuwei; Zhang, Na; Zhao, Shuang; Zeng, Hanjiang; Deng, Wen; Huang, Zixing; Liu, Sanyuan; Song, Bin title: A Quantitative and Radiomics approach to monitoring ARDS in COVID-19 patients based on chest CT: a retrospective cohort study date: 2020-07-06 journal: Int J Med Sci DOI: 10.7150/ijms.48432 sha: doc_id: 344978 cord_uid: m672rnze Rationale: Acute respiratory distress syndrome (ARDS) is one of the major reasons for ventilation and intubation management of COVID-19 patients but there is no noninvasive imaging monitoring protocol for ARDS. keywords: ards; covid-19; existence; features; model; patients; radiomics; sets cache: cord-344978-m672rnze.txt plain text: cord-344978-m672rnze.txt item: #210 of 227 id: cord-345028-56hg62be author: Flinspach, Armin Niklas title: Volatile Isoflurane in Critically Ill Coronavirus Disease 2019 Patients—A Case Series and Systematic Review date: 2020-10-21 words: 4122 flesch: 29 summary: To the best of our knowledge, no studies have investigated the effect of isoflurane sedation in patients suffering from C-ARDS so far, and it remains understudied whether the observed pathophysiologic pulmonary abnormalities, such as exudative and proliferative phases of a diffuse alveolar injury, might have an impact on the feasibility of volatile sedation (25) (26) (27) . In this first report of applying volatile sedation in patients with C-ARDS, we demonstrated the feasibility of isoflurane sedation in five cases. keywords: anesthetics; ards; care; coronavirus; covid-19; isoflurane; patients; sedation; ventilation cache: cord-345028-56hg62be.txt plain text: cord-345028-56hg62be.txt item: #211 of 227 id: cord-346230-39oo7vnq author: Byrne, J. D. title: Prophylaxis with tetracyclines in ARDS: Potential therapy for COVID-19-induced ARDS? date: 2020-07-28 words: 1443 flesch: 30 summary: Despite the retrospective nature and small sample size, we envisage implications for prophylactic tetracycline therapy in patients with ARDS secondary to COVID-19. As tetracycline antibiotics are well tolerated and orally bioavailable, randomized prospective trials should be possible to further test their efficacy as a prophylactic therapy, specifically in patients at risk for the SARS-CoV-2 infection and development of ARDS. keywords: ards; patients; preprint; review cache: cord-346230-39oo7vnq.txt plain text: cord-346230-39oo7vnq.txt item: #212 of 227 id: cord-347871-w6274bdg author: Kloc, Malgorzata title: The multiple sclerosis (MS) drugs as a potential treatment of ARDS in COVID-19 patients date: 2020-07-31 words: 615 flesch: 24 summary: These drugs, through the inhibition of the RhoA/actin-dependent expression of virus receptors in the macrophages and macrophage recruitment to the lungs, have the potential to inhibit cytokine storm of long macrophages, reduce or eliminate ARDS and improve the outcome of COVID-19 infection. The entry of the virus to the lung epithelial cells and lung macrophages depends on the ACE2 receptor expressed on the surface of these cells. keywords: macrophages; rhoa cache: cord-347871-w6274bdg.txt plain text: cord-347871-w6274bdg.txt item: #213 of 227 id: cord-348823-u2gm3kyh author: Baksh, Mizba title: A Systematic Review of Cases of Acute Respiratory Distress Syndrome in the Coronavirus Disease 2019 Pandemic date: 2020-05-18 words: 2255 flesch: 41 summary: Novel coronavirus (2019-nCoV) situation report -1 COVID-19) Geographic differences in COVID-19 cases, deaths, and incidence -United States COVIDView: a weekly surveillance summary of U.S. COVID-19 activity Interim clinical guidance for management of patients with confirmed coronavirus disease (COVID-19) Tissue plasminogen activator (tPA) treatment for COVID-19 associated acute respiratory distress syndrome (ARDS): a case series Pathological findings of COVID-19 associated with acute respiratory distress syndrome Rapid progression to acute respiratory distress syndrome: review of current understanding of critical illness from COVID-19 infection Lung involvement found on chest CT scan in a pre-symptomatic person with SARS-CoV-2 infection: a case report The clinical pathology of severe acute respiratory syndrome (SARS): a report from Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Studies of severe acute respiratory syndrome coronavirus pathology in human cases and animal models Covid-19 -considerations for the paediatric rheumatologist Meta-analysis of preclinical studies of fibrinolytic therapy for acute lung injury Prevention of adult respiratory distress syndrome with plasminogen activator in pigs Severe hypoxemic respiratory failure Salvage therapies for refractory hypoxemia in ARDS Clinical course and mortality risk of severe COVID-19 Higher mortality rate in ventilated COVID-19 patients in large sample Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis Information for clinicians on investigational therapeutics for patients with COVID-19 Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review Brief review on COVID-19: the 2020 pandemic caused by SARS-CoV-2 . There could be a high risk of mortality (about two-thirds) in ventilated patients according to new data from the United Kingdom's Intensive Care National Audit and Research Center (ICNARC), but this was unclear [19] . keywords: acute; ards; cases; covid-19; patients; sars cache: cord-348823-u2gm3kyh.txt plain text: cord-348823-u2gm3kyh.txt item: #214 of 227 id: cord-349197-3trr8d0u author: Ventura, Francesco title: Two Fatal Cases of Hidden Pneumonia in Young People date: 2010-04-28 words: 2510 flesch: 34 summary: Definitions, mechanisms, relevant outcomes, and clinical trial coordination Irwin and Rippe's intensive care medicine, 5th edn Abbas AK Robbins and Cotran pathologic basis of disease Nonhomogeneous immunostaining of hyaline membranes in different manifestations of diffuse alveolar damage The acute respiratory distress syndrome Mechanisms of sepsis-induced organ dysfunction Sepsis Definitions Conference A multicenter registry of patients with acute respiratory distress syndrome. Results from the ALIVE study Post-mortem diagnosis of sepsis Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults Incidence, clinical course, and outcome in 217 patients with acute respiratory distress syndrome The authors thank Prof. Vittorio Fineschi for his help in histological and immunohistochemical studies. keywords: ards; cases; distress; lung; pneumonia; syndrome cache: cord-349197-3trr8d0u.txt plain text: cord-349197-3trr8d0u.txt item: #215 of 227 id: cord-349201-d88g5toc author: Yu, Feng title: Exploring the biomarkers associated with different host inflammation of acute respiratory distress syndrome (ARDS) from lung metabolomics in mice date: 2020-10-13 words: 6163 flesch: 44 summary: The severity of lung injury was evaluated. The four following indicators of lung injury were used to arrive at this score: alveolar congestion; bleeding; gap or vascular wall neutrophil infiltration or aggregation; and alveolar septal thickening or transparent membrane formation. keywords: acute; ali; ards; clp; group; inflammatory; injury; lps; lung; metabolic; metabolites; mice; splen; splenectomy cache: cord-349201-d88g5toc.txt plain text: cord-349201-d88g5toc.txt item: #216 of 227 id: cord-349329-f0pbd968 author: Bosteels, Cedric title: Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial date: 2020-06-05 words: 12419 flesch: 40 summary: The study will be conducted cfr the latest version of the ICH E6 (R2) GCP guidelines, creating a standard for the design, conduct, performance, monitoring, auditing, recording, analyses and reporting of clinical studies that provides assurance that the data and reported results are accurate and that the rights, integrity and confidentiality of study subjects are protected. Monitoring services will consist of the following (non-exhaustive list): -review of informed consents and the followed process -check on recruitment status -checking for protocol deviations/violations -checking GCP compatibility -check on safety reporting compliance -IMP handling and storage -review of study data … This study can be inspected at any time by regulatory agencies during or after completion of the study. keywords: acute; ards; blood; covid-19; csf; data; day; days; failure; group; intervention; leukine; lung; patients; period; sargramostim; study; subject; treatment cache: cord-349329-f0pbd968.txt plain text: cord-349329-f0pbd968.txt item: #217 of 227 id: cord-349440-jxigsdzh author: Gattinoni, Luciano title: COVID-19 phenotypes: leading or misleading? date: 2020-07-02 words: 565 flesch: 39 summary: The fact that COVID-19 patients with similar oxygenation efficiency may have markedly different compliance (and VILI risk) is apparent to any clinician who has ever looked after a number of these patients. The perils of premature phenotyping in COVID: a call for caution COVID-19 pneumonia: different respiratory treatments for different phenotypes? Management of COVID-19 Respiratory Distress keywords: authors; patients cache: cord-349440-jxigsdzh.txt plain text: cord-349440-jxigsdzh.txt item: #218 of 227 id: cord-349980-x1h5dhn9 author: Ge, Huiqing title: Lung Mechanics of Mechanically Ventilated Patients With COVID-19: Analytics With High-Granularity Ventilator Waveform Data date: 2020-08-21 words: 3550 flesch: 41 summary: Recruitment maneuver was not able to improve lung compliance. As compared with supine positioning, prone positioning was associated with 2.31 ml/cmH(2)O (95% CI: 1.75 to 2.86; p < 0.001) increase in lung compliance. keywords: compliance; covid-19; lung; patients; positioning; survivors; ventilator cache: cord-349980-x1h5dhn9.txt plain text: cord-349980-x1h5dhn9.txt item: #219 of 227 id: cord-351624-32opyo0i author: Kappel, Coralea title: A case of possible Fournier’s gangrene associated with proning in COVID-19 ARDS date: 2020-07-27 words: 693 flesch: 38 summary: Nevertheless, given the prolonged duration of ventilation required by most COVID-19 patients and the risk of both common and unique complications due to proning (as highlighted by this case), clinicians ought to be increasingly vigilant with monitoring. A prospective survey of early 12-h prone positioning effects in patients with acute respiratory distress syndrome Clinical characteristics of 113 deceased patients with coronavirus disease 2019, retrospective study Clinical characteristics of coronavirus disease 2019 in China Disclosures None. Editorial responsibility This submission was handled by Dr. Gregory L. Bryson, Deputy Editor-in-Chief, Canadian Journal of Anesthesia. keywords: covid-19; patient; proning cache: cord-351624-32opyo0i.txt plain text: cord-351624-32opyo0i.txt item: #220 of 227 id: cord-352065-960xqft4 author: Rello, Jordi title: Update in COVID-19 in the Intensive Care Unit from the 2020 HELLENIC Athens International Symposium date: 2020-10-22 words: 4979 flesch: 32 summary: Regarding detection and diagnosis, studies have used machine learning algorithms to predict the criticality of COVID-19 positive patients using clinical features and identifying which of them have statistically significant hazard errors [64, 65] . COVID-19 infection has shown a great variability in terms of mortality in different regions around the globe. keywords: coronavirus; cov-2; covid-19; disease; icu; infection; lung; pandemic; patients; phenotype; pneumonia; sars cache: cord-352065-960xqft4.txt plain text: cord-352065-960xqft4.txt item: #221 of 227 id: cord-352196-rpyoeg9n author: Alberici, Federico title: A report from the Brescia Renal COVID Task Force on the clinical characteristics and short-term outcome of hemodialysis patients with SARS-CoV-2 infection. date: 2020-05-08 words: 2632 flesch: 46 summary: Reports would suggest a more severe disease course in patients with CKD(2) although outcomes in MHD patients is still unclear with earlier small case series suggesting a milder course (3) . Management of MHD patients in the context of an epidemic poses several challenges: this group of patients usually requires caregiver assistance, transportation from home to the dialysis units as well as spending periods of time in crowded waiting areas before and after treatment (4) . keywords: ards; diagnosis; disease; patients; sars; symptoms cache: cord-352196-rpyoeg9n.txt plain text: cord-352196-rpyoeg9n.txt item: #222 of 227 id: cord-352365-b9cmviny author: Marchetti, Monia title: COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure date: 2020-06-24 words: 3899 flesch: 26 summary: [9, 10] , while both C3a and C5a increase endothelial permeability and activate endothelial cells, thereby increasing the expression of adhesion molecules and cytokines [11, 12] , and the distal complement activation product C5 b-9 triggers intracellular fluxes of calcium in epithelial and endothelial cells. This downregulation enhances C3a release and caspase 3 deposition onto endothelial cells [13] . keywords: ards; c5a; cells; complement; covid-19; damage; endothelial; imatinib; injury; lung; patients; sars cache: cord-352365-b9cmviny.txt plain text: cord-352365-b9cmviny.txt item: #223 of 227 id: cord-353594-z1vxamvp author: Gagiannis, Daniel title: Clinical, Serological, and Histopathological Similarities Between Severe COVID-19 and Acute Exacerbation of Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD) date: 2020-10-02 words: 5017 flesch: 34 summary: ANA titers ≥1:320 and/or positive ENA immunoblots were detected in 11/13 (84.6%) COVID-19 patients with ARDS, in 1/9 (11.1%) COVID-19 patients without ARDS (p = 0.002) and in 4/10 (40%) patients with non-COVID-19-associated pneumonias (p = 0.039). Our findings indicate that autoimmune mechanisms determine both clinical course and long-term sequelae after SARS-CoV-2 infection, and the presence of autoantibodies might predict adverse clinical course in COVID-19 patients. keywords: ana; anti; ards; autoantibodies; cases; cov-2; covid-19; disease; lung; patients; pneumonia; sars; table cache: cord-353594-z1vxamvp.txt plain text: cord-353594-z1vxamvp.txt item: #224 of 227 id: cord-354829-god79qzw author: Mao, Kaimin title: Identification of robust genetic signatures associated with lipopolysaccharide-induced acute lung injury onset and astaxanthin therapeutic effects by integrative analysis of RNA sequencing data and GEO datasets date: 2020-09-23 words: 6341 flesch: 39 summary: Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apoptosis dependent on Drp1-mediated mitochondrial fission Astaxanthin alleviated acute lung injury by inhibiting oxidative/nitrative stress and the inflammatory response in mice Astaxanthin prevents against lipopolysaccharideinduced acute lung injury and sepsis via inhibiting activation of MAPK/NF-κB NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and metaanalysis clusterProfiler: an R package for comparing biological themes among gene clusters Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential Evidence for chemokine synergy during neutrophil migration in ARDS Fernández-Botrán R. Modulation of acute inflammation by targeting glycosaminoglycan-cytokine interactions Contribution of neutrophils to acute lung injury Antiinflammatory activity of a novel family of aryl ureas compounds in an endotoxin-induced airway epithelial cell injury model C-X-C motif chemokine 13 (CXCL13) is a prognostic biomarker of idiopathic pulmonary fibrosis ZBP1: innate sensor regulating cell death and inflammation Dynamic gene expression analysis in a H1N1 influenza virus mouse pneumonia model The CC chemokine ligand 2 (CCL2) mediates fibroblast survival through IL-6 Complement inhibition decreases early fibrogenic events in the lung of septic baboons The cytokine-serum amyloid achemokine network Serum amyloid A is a biomarker of severe coronavirus disease and poor prognosis Serum amyloid A3 is a high density lipoprotein-associated acute-phase protein Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3 Long non-coding RNA MALAT1 regulates hyperglycaemia induced inflammatory process in the endothelial cells IL-6 induced lncRNA MALAT1 enhances TNF-α expression in LPS-induced septic cardiomyocytes via activation of SAA3 Emerging functions of serum amyloid a in inflammation Suppression of lipopolysaccharide-induced inflammatory response by fragments from serum amyloid a Serum amyloid a promotes LPS clearance and suppresses LPS-induced inflammation and tissue injury Knockdown of miR-660 protects nucleus pulposus cells from TNF-a-induced apoptosis by targeting serum amyloid A1 IRF7: activation, regulation, modification and function Attenuation of interferon regulatory factor 7 activity in local infectious sites of trachea and lung for preventing the development of acute lung injury caused by influenza a virus Mir-302c mediates influenza a virus-induced IFNβ expression by targeting NF-κB inducing kinase Then, we performed a meta-analysis using NetworkAnalyst (http://www.networkanalyst.ca), which is a comprehensive web-based tool designed to perform meta-analyses of gene expression data [20] . keywords: acute; ali; analysis; ards; ast; data; degs; expression; genes; group; injury; lps; lung; meta; mice; rna cache: cord-354829-god79qzw.txt plain text: cord-354829-god79qzw.txt item: #225 of 227 id: cord-355038-o2hr5mox author: None title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 words: 102622 flesch: 49 summary: No significant difference between the NE and AVP groups for lactate clearance between H0 and H6 (25.6 [− 7.31 to 35.34]% vs 47.84 [13.42-82.73 ]%, p = 0.686). D: blood frequency of MAIT cells in patients with pneumonia compared with healthy controls (as % of total T cells) keywords: 0.001; acute; admission; adult patients; age; aim; aki; analysis; antibiotic; ards; ards patients; association; blood; cardiac; care; care patients; care unit; cases; characteristics; children; cohort; compliance; complications; conclusion; conflict; control; data; days; death; diagnosis; disclosure; disease; duration; dysfunction; early; ecmo; end; ethics regulations; factors; failure; fig; following; france; group; high; hospital; hospital mortality; icu admission; icu mortality; icu patients; icu stay; impact; incidence; infection; influenza patients; injury; intensive; intensive care; interest; international; intubation; january; length; management; mean; median; medical; methods; model; months; mortality; mortality rate; multivariate; n =; national; niv; non; objective; outcome; p =; patients; period; pneumonia; post; pressure; prognosis; pulmonary; rate; rationale; respiratory; results; risk; score; sepsis; septic; severity; shock; sofa; stay; studies; study; study period; support; survival; syndrome; therapy; time; total; treatment; unit; use; ventilation; weaning; years cache: cord-355038-o2hr5mox.txt plain text: cord-355038-o2hr5mox.txt item: #226 of 227 id: cord-355208-hpldjsc5 author: Leisman, Daniel E. title: Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation date: 2020-04-28 words: 1418 flesch: 31 summary: COVID-19 patients develop profound hypoxemia early in their disease course. Importantly, admission AngII levels in COVID-19 patients are reportedly twice the normal levels [13] . keywords: angii; covid-19; endothelial; patients; vascular cache: cord-355208-hpldjsc5.txt plain text: cord-355208-hpldjsc5.txt item: #227 of 227 id: cord-355847-1ru15s5a author: Convertino, Irma title: Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients date: 2020-06-11 words: 2944 flesch: 35 summary: Several drugs, endowed with modulating activity on cytokine pathways, including anti-IL-6, anti-TNF, and Janus kinase (JAK) inhibitors, currently approved for the treatment of immune-mediated inflammatory diseases, have been suggested or could be yet taken into account for experimental use in COVID-19 patients with ARDS and/or pneumonia ( Fig. 1 ). Moreover, a multicenter randomized clinical trial in COVID-19 patients with ARDS, treated with tocilizumab at a dose of 4~8 mg/kg once, and an additional same dose when fever persists within 24 h after the first administration, has been approved in China [16] . keywords: anti; ards; covid-19; il-6; iqr; patients; tnf cache: cord-355847-1ru15s5a.txt plain text: cord-355847-1ru15s5a.txt