# bib

id: cord-352502-vdm55zvq
author: Salton, Francesco
title: Response to: Factors limiting the utility of bronchoalveolar lavage in the diagnosis of COVID-19
date: 2020-09-17
extension: .txt
mime: text/plain
words: 646
sentence: 22
flesch: 39
cache: cache/cord-352502-vdm55zvq.txt
txt: txt/cord-352502-vdm55zvq.txt
summary:
  Factors limiting the utility of bronchoalveolar lavage in the diagnosis of COVID-19 date: 2020-09-17 journal: Eur Respir J DOI: 10.1183/13993003.03383-2020 sha: doc_id: 352502 cord_uid: vdm55zvq We aimed at evaluating not the diagnostic yield of BAL in COVID-19, but the agreement between negative upper respiratory tract swabs and BAL to exclude COVID-19, stressing that BAL is likely negative if swabs and chest CT are concordantly negative. These findings support our main observation that BAL is likely to be negative if one or more upper respiratory tract specimens and thoracic imaging are concordantly negative, therefore it should be only reserved for those cases in which a high clinical and radiological suspicion for COVID-19 stands despite negative upper respiratory tract swabs.


id: cord-295718-nt2n9p5v
author: Vissichelli, N. C.
date: 2019-12-31
extension: .txt
mime: text/plain
words: 2144
sentence: 107
flesch: 32
cache: cache/cord-295718-nt2n9p5v.txt
txt: txt/cord-295718-nt2n9p5v.txt
title:
  Bronchoalveolar lavage to evaluate new pulmonary infiltrates in allogeneic hematopoietic stem cell transplant recipients: impact on antimicrobial optimization

summary:
  This is recognized in the 2019 American Thoracic Society guidelines, which suggest moving to BAL AGA and requesting BAL Aspergillus PCR when serum AGA is negative. Antiviral initiation was more likely with positive BAL multiplex PCR (OR 17.33, P=0.010).


id: cord-292772-xdic7rcy
author: Petini, Matteo
date: 2019-04-26
extension: .txt
mime: text/plain
words: 2471
sentence: 117
flesch: 39
cache: cache/cord-292772-xdic7rcy.txt
txt: txt/cord-292772-xdic7rcy.txt
title:
  Nested–polymerase chain reaction detection of Pneumocystis carinii f. sp. canis in a suspected immunocompromised Cavalier King Charles spaniel with multiple infections

summary:
  21 Pneumocystosis in dogs: metaanalysis of 43 published cases including clinical signs, diagnostic procedures, and treatment Pneumocystis carinii pneumonia in dogs-a diagnostic challenge Occurrence of Pneumocystis carinii in canine distemper Pneumocystis carinii pneumonia in two Cavalier King Charles Spaniels Common variable immunodeficiency in miniature dachshunds affected with Pneumonocystis carinii pneumonia Pneumocystis pneumonia in two Cavalier King Charles Spaniel littermates Common variable immune deficiency in a Pomeranian with Pneumocystis carinii pneumonia Pneumocystis carinii infection with severe pneumomediastinum and lymph node involvement in a Whippet mixedbreed dog Molecular diagnosis of pneumocystis pneumonia in dogs Improved detection of Pneumocystis jirovecii in upper and lower respiratory tract specimens from children with suspected pneumocystis pneumonia using real-time PCR: a prospective study Pneumocystis PCR: it is time to make PCR the test of choice ECIL guidelines for the diagnosis of Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients The unroot phylogenetic tree constructed using mtSSU rRNA sequences showed that Pneumocystis carinii f. sp. canis was distinct from Pneumocystis spp.


id: cord-325068-j1lfq60o
author: Pene, Frédéric
title: Coronavirus 229E-Related Pneumonia in Immunocompromised Patients
date: 2003-10-01
extension: .txt
mime: text/plain
words: 2586
sentence: 106
flesch: 29
cache: cache/cord-325068-j1lfq60o.txt
txt: txt/cord-325068-j1lfq60o.txt
summary:
  Three-year study with coronavirus strains OC43 and 229E Viruses and bacteria in the etiology of the common cold An Outbreak of coronavirus OC43 respiratory infection in Normandy, France Coronavirus as a possible cause of severe acute respiratory syndrome Survival benefit of highdose therapy in poor-risk aggressive non-Hodgkin's lymphoma: final analysis of the prospective LNH87-2 protocol-a groupe d'Etude des lymphomes de l'Adulte study Detection of varicella-zoster virus DNA by polymerase chain reaction in the cerebrospinal fluid of patients suffering from neurological complications associated with chicken pox or herpes zoster Direct diagnosis of human respiratory coronaviruses 229E and OC43 by the polymerase chain reaction Cytomegalovirus: an unexpected cause of ventilator-associated pneumonia Coronavirusrelated nosocomial viral respiratory infections in a neonatal and paediatric intensive care unit: a prospective study Nosocomial adenovirus infection in a paediatric respiratory unit Electron microscopic studies of coronavirus Diagnosis of human coronavirus infection by immunofluorescence: method and application to respiratory disease in hospitalized children Detection of human coronavirus 229E in nasal washings using RNA:RNA hybridisation Occurrence and frequency of coronavirus infections in humans as determined by enzyme-linked immunosorbent assay Mouse hepatitis virus strain JHM infects a human hepatocellular carcinoma cell line Comparison of immunofluorescence with monoclonal antibodies and RT-PCR for the detection of human coronaviruses 229E and OC43 in cell culture Rhinovirus infections in myelosuppressed adult blood and marrow transplant recipients Impact of respiratory virus infections on persons with chronic underlying conditions Rhinovirus infections in hematopoietic stem cell transplant recipients with pneumonia Coronavirus pneumonia following autologous bone marrow transplantation for breast cancer The efficacy and tolerance of intranasal interferons: studies at the Common Cold Unit The role of gamma interferon in infection of susceptible mice with murine coronavirus, MHV-JHM Although chronic underlying conditions are major determinants of severe respiratory virus infections, few data about coronavirus-related pneumonia in immunocompromised patients are available.


id: cord-353256-7nfklun9
author: Eroglu‐Ertugrul, Nesibe Gevher
title: The value of flexible bronchoscopy in pulmonary infections of immunosuppressed children
date: 2019-11-22
extension: .txt
mime: text/plain
words: 3097
sentence: 120
flesch: 31
cache: cache/cord-353256-7nfklun9.txt
txt: txt/cord-353256-7nfklun9.txt
summary:
  No serious complications because bronchoscopy have been detected in the juvenile age group among immunocompromised patients as found in our study and reported in the previous literature; 15, 17 however, this is not the case in adult patients with immune deficiency, who exhibited a higher incidence of serious complications. These results may be related to the protective effect of prophylactic antibiotics that had been administered since the beginning of the BMT process as well as the preparation regimens that cause T-cell depletion in order to prevent the occurrence of graft versus host disease, both of which may play a critical role in the increased frequency of the presence of viral and opportunistic agents in BMT patients.


id: cord-321393-ffulkqrf
author: Versluys, Anne Birgitta
date: 2015-06-11
extension: .txt
mime: text/plain
words: 3416
sentence: 182
flesch: 44
cache: cache/cord-321393-ffulkqrf.txt
txt: txt/cord-321393-ffulkqrf.txt
title:
  High Diagnostic Yield of Dedicated Pulmonary Screening before Hematopoietic Cell Transplantation in Children

summary:
  Lung screening can potentially impact selection of HCT patients as well as affect preemptive treatment and prognosis. We might also conclude that with current treatment strategies for this group of pulmonary compromised patients, we manage to have comparable outcome.


id: cord-281418-mvgp6qfv
author: Soccal, P. M.
date: 2010-07-15
extension: .txt
mime: text/plain
words: 3563
sentence: 137
flesch: 35
cache: cache/cord-281418-mvgp6qfv.txt
txt: txt/cord-281418-mvgp6qfv.txt
title:
  Upper and Lower Respiratory Tract Viral Infections and Acute Graft Rejection in Lung Transplant Recipients

summary:
  Clinical impact of communityacquired respiratory viruses on bronchiolitis obliterans after lung transplant Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on the lower respiratory tract infections of lung transplant recipients Respiratory viruses and chronic rejection in lung transplant recipients Human metapneumovirus in lung transplant recipients and comparison to respiratory syncytial virus Respiratory viral infections in transplant recipients A single-season prospective study of respiratory viral infections in lung transplant recipients Absence of human bocavirus in bronchoalveolar lavage fluid of lung transplant patients Diagnosis of human metapneumovirus infection in immunosuppressed lung transplant recipients and children evaluated for pertussis Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment Human metapneumovirus infection in lung transplant recipients: clinical presentation and epidemiology Lower respiratory viral illnesses: improved diagnosis by molecular methods and clinical impact Respiratory viral infections are a distinct risk for bronchiolitis obliterans syndrome and death Clinical features and outcomes of paramyxoviral infection in lung transplant recipients treated with ribavirin Infectious etiology of bronchiolitis obliterans: the respiratory viruses connection: myth or reality? Characterization of virus-mediated inhibition of mixed chimerism and allospecific tolerance Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome Community acquired respiratory viral infections after lung transplantation: clinical features and long-term consequences Parainfluenza virus infection in adult lung transplant recipients: an emergent clinical syndrome with implications on allograft function The epidemiology of parainfluenza virus infection in lung transplant recipients Treatment of respiratory syncytial virus pneumonia in a lung transplant recipient: case report and review of the literature Influenza virus infection in adult solid organ transplant recipients Respiratory viruses in bronchoalveolar lavage: a hospital-based cohort study in adults A prospective hospital-based study of the clinical impact of non-severe acute respiratory syndrome (non-SARS)-related human coronavirus infection Swiss Paediatric Respiratory Research Group. Paradoxically, we even observed a negative association between an episode of respiratory viral infection and the subsequent cumulative risk of developing acute rejection.


id: cord-006676-a21tdgns
author: Abul, H.
title: Levels of IL-8 and myeloperoxidase in the lungs of pneumonia patients
date: 2001
extension: .txt
mime: text/plain
words: 3628
sentence: 162
flesch: 44
cache: cache/cord-006676-a21tdgns.txt
txt: txt/cord-006676-a21tdgns.txt
summary:
  Since alveolar macrophages are the major source of IL-8 in the lung, the local production of IL-8 by these cells may be responsible for the recruitment of PMNs into the pulmonary interstitial or air space in a variety of lung diseases. Recent reports have considered IL-8 as the most potent and major PMN chemoattractant factor in lung diseases [13]


id: cord-337637-wehstffa
author: Ferreira, Flavia de A
title: Comparison of atopic and nonatopic children with chronic cough: Bronchoalveolar lavage cell profile
date: 2007-08-28
extension: .txt
mime: text/plain
words: 3878
sentence: 152
flesch: 44
cache: cache/cord-337637-wehstffa.txt
txt: txt/cord-337637-wehstffa.txt
summary:
  Chronic cough can be defined as a cough persisting for at least 6 weeks 1 however this definition is arguable and others have regarded duration more than 4 weeks as chronic cough. Chronic cough in children All that cough is not asthma State of art: cough, cough receptors and asthma in children Comparison of atopic cough with cough variant asthma: is atopy cough a precursor of asthma? Eosinophilic tracheobronchitis and airway hypersensitivity in chronic nonproductive cough Correlation of bronchial eosinophils and mast cell activation with bronchial hyperresponsiveness in children with asthma Inflammatory mediators in bronchoalveolar lavage samples for children with and without asthma Bronchoalveolar lavage cell profiles in children with asthma, infantile wheeze, chronic cough or cystic fibrosis Evaluation and outcome of young children with chronic cough Cough quality in children: a comparison of subjects�s bronchoscopic findings Gastroesophageal reflux and inflammation in bronchoalveolar lavage in children (Abstract) Airway inflammation in nonasthmatic subjects with chronic cough Evaluation and outcome of young children with chronic cough Cough and reflux esophagitis in children: their co existence and airway cellularity Bronchoalveolar lavage in children.


id: cord-005748-2rpiv4d9
author: Giantsou, Elpis
date: 2007-06-05
extension: .txt
mime: text/plain
words: 3821
sentence: 129
flesch: 31
cache: cache/cord-005748-2rpiv4d9.txt
txt: txt/cord-005748-2rpiv4d9.txt
title:
  De-escalation therapy rates are significantly higher by bronchoalveolar lavage than by tracheal aspirate

summary:
  key: cord-005748-2rpiv4d9 authors: Giantsou, Elpis; Liratzopoulos, Nikolaos; Efraimidou, Eleni; Panopoulou, Maria; Alepopoulou, Eleonora; Kartali-Ktenidou, Sofia; Manolas, Konstantinos title: De-escalation therapy rates are significantly higher by bronchoalveolar lavage than by tracheal aspirate date: 2007-06-05 journal: Intensive Care Med DOI: 10.1007/s00134-007-0619-x sha: doc_id: 5748 cord_uid: 2rpiv4d9 OBJECTIVE: To assess outcomes with de-escalation therapy in ventilator-associated pneumonia (VAP). PATIENTS AND PARTICIPANTS: VAP was diagnosed by positive quantitative cultures of both tracheal aspirate and bronchoalveolar lavage (BAL) and treated appropriately for all significant isolates of tracheal aspirate and BAL in 143 patients who were assigned to de-escalation therapy by BAL or tracheal aspirate.


id: cord-006000-ekwpkzqv
author: Bewig, B.
title: Eosinophilic alveolitis in BAL after lung transplantation
date: 1999
extension: .txt
mime: text/plain
words: 4209
sentence: 209
flesch: 37
cache: cache/cord-006000-ekwpkzqv.txt
txt: txt/cord-006000-ekwpkzqv.txt
summary:
  The histological changes in transbronchial biopsy after treatment of acute lung rejection in heart-lung transplants Bronchoalveolar lavage and transbronchial lung biopsy during acute rejection and infection in heart-lung transplant patients Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion Bronchoalveolar lavage in allergic asthmatics Study of eosinophilia and hepatic dysfunctionas a predictor of rejection in human liver transplantation Non-invasive parameters for detection of cardiac allograft rejection Cytokine production at the site of disease in chronic eosinophilic pneumonitis Immunocytologic analysis of cells obtained from bronchoalveolar lavage in a model of rat lung allograft rejection Partcipation of interleukin-5 and interleukin-8 in the eosinophil migration induced by a large volume of saline Prognostic role of eosinophils in pulmonary fibrosis Activation of eosinophils and fibroblasts assessed by eosinophil cationic crotein and hyaluronan in BAL. Analysis of BAL fluid BAL fluid was transported to the laboratory within 1 h for immediate processing.


id: cord-001280-skavefji
author: Choi, Sang-Ho
date: 2014-05-13
extension: .txt
mime: text/plain
words: 4139
sentence: 166
flesch: 31
cache: cache/cord-001280-skavefji.txt
txt: txt/cord-001280-skavefji.txt
title:
  Usefulness of Cellular Analysis of Bronchoalveolar Lavage Fluid for Predicting the Etiology of Pneumonia in Critically Ill Patients

summary:
  For positiveand negative predictive values, the prevalence of bacterial pneumonia in severe pneumonia patients admitted to the medical ICU was assumed to be 35.9%, based on our previous study [14] . By using strict enrollment criteria, however, only a small proportion of pneumonia patients who underwent bronchoscopic BAL was finally included (Figure 1 ), which might have influenced on the results.


id: cord-291286-diwigcy9
author: De Schutter, Iris
date: 2011-06-15
extension: .txt
mime: text/plain
words: 4080
sentence: 166
flesch: 36
cache: cache/cord-291286-diwigcy9.txt
txt: txt/cord-291286-diwigcy9.txt
title:
  Microbiology of Bronchoalveolar Lavage Fluid in Children With Acute Nonresponding or Recurrent Community-Acquired Pneumonia: Identification of Nontypeable Haemophilus influenzae as a Major Pathogen

summary:
  A heterogeneous group of patients was included, which reflected pediatric CAP cases that often require hospitalization in developed countries. NR-CAP case patients were defined according to current pediatric CAP guidelines [15] as patients with persistent fever (.38.5°C) and persistent elevated infection parameters in the peripheral blood, associated in some cases with worsening consolidation visible on chest radiographs after at least 48 h of antibiotic treatment.


id: cord-016732-mdyu69ca
author: Pesci, Alberto
title: Il lavaggio broncoalveolare nelle pneumopatie infiltrative diffuse
date: 2007
extension: .txt
mime: text/plain
words: 4102
sentence: 216
flesch: 36
cache: cache/cord-016732-mdyu69ca.txt
txt: txt/cord-016732-mdyu69ca.txt
summary:
  I lavoratori esposti ma non affetti da malattia possono presentare un aumento di linfociti che permette di ipotizzare la presenza di una alveolite subclinica. Il lavaggio broncoalveolare nelle pneumopatie infiltrative diffuse La polmonite da ipersensibilità è caratterizzata dalla presenza di percentuali di linfociti nel BAL (spesso >50% e talora fino al 90%) raramente riscontrabili in altre pneumopatie.


id: cord-257459-elzhww5a
author: Van Driessche, L.
date: 2017-04-19
extension: .txt
mime: text/plain
words: 4461
sentence: 195
flesch: 48
cache: cache/cord-257459-elzhww5a.txt
txt: txt/cord-257459-elzhww5a.txt
title:
  A Deep Nasopharyngeal Swab Versus Nonendoscopic Bronchoalveolar Lavage for Isolation of Bacterial Pathogens from Preweaned Calves With Respiratory Disease

summary:
  Therefore, the objectives of our study were (1) to determine the outcome of bacterial culture results, isolation rates, and agreement for samples taken with DNS and nonendoscopic BAL with respect to Pasteurellaceae and Mycoplasma bovis. infections in preweaned calves; (2) to determine the polymicrobial nature of DNS and BAL samples; and (3) to determine whether a polymicrobial DNS culture result, caused by the nasopharyngeal flora or unhygienic sampling, influences BAL culture results. The extent of commensal overgrowth and agreement of BAL with DNS culture results in preweaned calves are unknown.


id: cord-346411-d2re00r9
author: Boonyaratanakornkit, Jim
date: 2020-02-01
extension: .txt
mime: text/plain
words: 4419
sentence: 165
flesch: 38
cache: cache/cord-346411-d2re00r9.txt
txt: txt/cord-346411-d2re00r9.txt
title:
  Predictive Value of Respiratory Viral Detection in the Upper Respiratory Tract for Infection of the Lower Respiratory Tract With Hematopoietic Stem Cell Transplantation

summary:
  In addition, using quantitative PCR methodology, we aimed to define the role of viral load in respiratory virus LRT detection. We also found that CMV-seropositive HCT recipients had an increased risk for LRT respiratory virus detection.


id: cord-010819-a0nbmx3l
author: Stettler, Gregory R.
title: Do not drink and lyse: alcohol intoxication increases fibrinolysis shutdown in injured patients
date: 2020-03-10
extension: .txt
mime: text/plain
words: 4473
sentence: 193
flesch: 42
cache: cache/cord-010819-a0nbmx3l.txt
txt: txt/cord-010819-a0nbmx3l.txt
summary:
  In the injured patient, high blood alcohol levels are associated with increased incidence of fibrinolysis shutdown. Elevated levels of PAI-1 are associated with increased fibrinolysis shutdown, which is the most common fibrinolytic phenotype in the injured population and is associated with an increased mortality due to macro-and microthrombotic complications such as venous thrombotic events (VTE) and multiple organ failure (MOF) [15] .


id: cord-286346-h87vcmrd
author: Mikulska, Malgorzata
date: 2019-02-07
extension: .txt
mime: text/plain
words: 4609
sentence: 178
flesch: 39
cache: cache/cord-286346-h87vcmrd.txt
txt: txt/cord-286346-h87vcmrd.txt
title:
  Use of Aspergillus fumigatus real-time PCR in bronchoalveolar lavage samples (BAL) for diagnosis of invasive aspergillosis, including azole-resistant cases, in high risk haematology patients: the need for a combined use with galactomannan

summary:
  Another explanation for low sensitivity of this qPCR, even in a subgroup of BAL GM positive patients with probable IA, might be the infection with species other than A. fumigatus which are not detected by this assay. Among 36 patients receiving mould active agents, nine had positive BAL GM, and qPCR was positive in seven of them, compared to five among 26 of those not receiving antifungals (P < .05).


id: cord-355623-tmr1ieg1
author: Gallucci, Marcella
title: When the Cough Does Not Improve: A Review on Protracted Bacterial Bronchitis in Children
date: 2020-08-07
extension: .txt
mime: text/plain
words: 4322
sentence: 145
flesch: 33
cache: cache/cord-355623-tmr1ieg1.txt
txt: txt/cord-355623-tmr1ieg1.txt
summary:
  ERS statement on protracted bacterial bronchitis in children Guidelines for evaluating chronic cough in pediatrics Management of children with chronic wet cough and protracted bacterial bronchitis: CHEST guideline and expert panel report ERS guidelines on the diagnosis and treatment of chronic cough in adults and children Recommendations for the assessment and management of cough in children Minimally important change in a parent-proxy quality-of-life questionnaire for pediatric chronic cough Update on pediatric cough Chronic wet cough: protracted bronchitis, chronic suppurative lung disease and bronchiectasis Evaluation and outcome of young children with chronic cough Protracted bacterial bronchitis: the last decade and the road ahead A multicenter study on chronic cough in children: burden and etiologies based on a standardized management pathway Evaluation of 563 children with chronic cough accompanied by a new clinical algorithm Prospective characterization of protracted bacterial bronchitis in children How cigarette smoke skews immune responses to promote infection, lung disease and cancer Utility of signs and symptoms of chronic cough in predicting specific cause in children An underestimated cause of chronic cough: the protracted bacterial bronchitis Bronchoalveolar lavage in children Comparison of cell profiles in separately evaluated fractions of bronchoalveolar lavage (BAL) fluid in children Protracted bacterial bronchitis: bronchial aspirate versus bronchoalveolar lavage findings: a single-centre retrospective study Wet cough in children: Infective and inflammatory characteristics in broncho-alveolar lavage fluid Outcomes in children treated for persistent bacterial bronchitis Three clinically distinct chronic pediatric airway infections share a common core microbiota The microbiota in bronchoalveolar lavage from young children with chronic lung disease includes taxa present in both the oropharynx and nasopharynx Protracted bacterial bronchitis (PBB) is a common cause of chronic wet cough in preschool children with no symptoms or signs of other specific causes, and resolution usually follows a 2-week course of an appropriate oral antibiotic.


id: cord-328918-nc0a77r6
author: Kuczia, Pawel
date: 2020-07-13
extension: .txt
mime: text/plain
words: 4462
sentence: 217
flesch: 40
cache: cache/cord-328918-nc0a77r6.txt
txt: txt/cord-328918-nc0a77r6.txt
title:
  Citrullinated histone H3, a marker of extracellular trap formation, is increased in blood of stable asthma patients

summary:
  H3cit was increased in asthma patients receiving systemic steroids (p = 0.02), as well as in subjects with BAL eosinophilia above 144 cells/ml (p = 0.02). Asthma patients were eligible if they had no exacerbation during the preceding 6 months.


id: cord-306346-rft22vo8
author: Rohde, G.
title: CXC chemokines and antimicrobial peptides in rhinovirus‐induced experimental asthma exacerbations
date: 2014-06-23
extension: .txt
mime: text/plain
words: 4662
sentence: 216
flesch: 44
cache: cache/cord-306346-rft22vo8.txt
txt: txt/cord-306346-rft22vo8.txt
summary:
  It has been shown before that 4 days after experimental RV infection, the inflammatory response of the upper airways is increased which is associated with increased symptoms and airways obstruction in asthmatics [20] . Experimental RV infection in humans provides an excellent model of virus-induced asthma under controlled conditions including application of a standard dose of a single virus serotype and standardized clinical data collection.


id: cord-004002-b35wm2db
author: Gaborit, Benjamin Jean
date: 2019-11-27
extension: .txt
mime: text/plain
words: 4895
sentence: 187
flesch: 34
cache: cache/cord-004002-b35wm2db.txt
txt: txt/cord-004002-b35wm2db.txt
title:
  Outcome and prognostic factors of Pneumocystis jirovecii pneumonia in immunocompromised adults: a prospective observational study

summary:
  Lymphocytes and neutrophils mean ratio were, respectively, 22% and 23% in HIV patients, 34% and 21% in non-HIV patients, 22% and 30% in dead patients, 35% and 19% in survivors patients, 36% and 21% with only PJP patients, 29% and 22% during coinfection. In survival analysis HIV patients presenting with PJP was associated with statistically better prognostic than that of patients with hematologic diseases or solid cancer (Additional file 1: Figures S2, S3) .


id: cord-335359-4rcj75tc
author: Jia, Bei
date: 2020-01-15
extension: .txt
mime: text/plain
words: 5130
sentence: 176
flesch: 33
cache: cache/cord-335359-4rcj75tc.txt
txt: txt/cord-335359-4rcj75tc.txt
title:
  Evaluation of a PCR-electrospray ionization mass spectrometry platform for detection and identification of fungal pathogens directly from prospectively collected bronchoalveolar lavage specimens

summary:
  Aspergillus was detected in 35 BAL samples by culture and/or PCR/ ESI-MS, 20 of which were considered to be related to lung infection by clinical context including underlying conditions, clinical features, and lung CT findings (Fig. 3) . Eighteen of them were detected by PCR/ ESI-MS; of which fifteen were verified by culture, and of which ten matched culture-based identification at the species level.


id: cord-011159-k2kca8zl
author: Kamel, Toufik
date: 2020-01-07
extension: .txt
mime: text/plain
words: 5116
sentence: 183
flesch: 40
cache: cache/cord-011159-k2kca8zl.txt
txt: txt/cord-011159-k2kca8zl.txt
title:
  Benefit-to-risk balance of bronchoalveolar lavage in the critically ill. A prospective, multicenter cohort study

summary:
  BAL respiratory tolerance was first assessed by recording the need for modification(s) in respiratory support as previously described [8] from the beginning of bronchoscopy to 24 h after, including need of tracheal intubation, increase by more than 50% in oxygen flow rate, or use of HFNC in patients under standard oxygen therapy, increase by more than 20% in gas flow rate or FiO 2 in patients initially under HFNC, need of non-invasive ventilation (NIV) in patients who initially had no mechanical respiratory support and increase by more than 20% in inspiratory pressure support or in positive end-expiratory pressure or in FiO 2 , in patients initially treated by NIV. Patients were included if (1) they had an indication to undergo a BAL as decided by their attending intensivist, (2) cellular analysis of BAL fluid by a pathologist was planned, and (3) consent had been obtained.


id: cord-256424-t3dtabi4
author: Bousbia, Sabri
title: Repertoire of Intensive Care Unit Pneumonia Microbiota
date: 2012-02-28
extension: .txt
mime: text/plain
words: 5650
sentence: 240
flesch: 34
cache: cache/cord-256424-t3dtabi4.txt
txt: txt/cord-256424-t3dtabi4.txt
summary:
  Some pathogens considered to be typical for ICU pneumonia such as Pseudomonas aeruginosa and Streptococcus species can be detected as commonly in controls as in pneumonia patients which strikingly highlights the existence of a core pulmonary microbiota. In preliminary results, we have reported the likely frequency of Tropheryma whipplei and the occurrence of vegetable DNA in pneumonia patients [12, 13] .


id: cord-017123-g1m1y38x
author: Sacco, Oliviero
title: Il lavaggio broncoalveolare (BAL) in età pediatrica
date: 2007
extension: .txt
mime: text/plain
words: 5443
sentence: 200
flesch: 37
cache: cache/cord-017123-g1m1y38x.txt
txt: txt/cord-017123-g1m1y38x.txt
summary:
  Lo sviluppo di più di 10 5 di colonie batteriche, inoculando nel terreno di coltura 1 ml di BALF della quota alveolare, si è dimostrato diagnostico per la presenza di broncopolmonite. May-Grunwald Giemsa ed il Diff-Quick (Merz & Dade A.G., Dudigen, Germany); a quest'ultima colorazione va spesso la preferenza dei laboratori di pneumologia, in quanto tutto il ciclo di colorazione si completa in circa 10 minuti.


id: cord-291960-1is0rv6c
author: Piñana, José Luis
date: 2019-02-21
extension: .txt
mime: text/plain
words: 5916
sentence: 204
flesch: 36
cache: cache/cord-291960-1is0rv6c.txt
txt: txt/cord-291960-1is0rv6c.txt
title:
  Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia

summary:
  The assessment of the performance of quantitative CMV DNA PCR testing for the diagnosis of CMV pneumonia faces several difficulties including: (i) the low incidence of this clinical event, (ii) the lack of a normalized procedure for CMV DNA PCR testing on BAL fluids, (iii) the non-negligible possibility of miscategorization of pneumonia cases as either being causally linked or unrelated to CMV when using BAL fluid specimens, or even lung tissue material, for CMV diagnosis, 8 (iv) the persistence of a large variability of CMV DNA loads provided by different real-time PCR assays, 31 -33 despite their calibration to the WHO International Standard for CMV DNA 24 and, as already mentioned, (v) the relegation of virological procedures for CMV detection in clinical specimens. In 41 episodes, CMV DNA BAL detection occurred in the face of an ongoing episode of CMV DNAemia (including two episodes that occurred in the setting of autopsy-proven CMV pneumonitis), and isolately in the remaining 15 episodes.


id: cord-340544-ce5ic04g
author: Sakata, Kenneth K.
title: Microbiologic yield of bronchoalveolar lavage specimens from stem cell transplant recipients
date: 2017-04-12
extension: .txt
mime: text/plain
words: 1894
sentence: 85
flesch: 33
cache: cache/cord-340544-ce5ic04g.txt
txt: txt/cord-340544-ce5ic04g.txt
summary:
  We sought to determine and elaborate on the microbiologic yield of BAL in SCT recipients, assess a correlation between BAL studies and less invasive means of pathogen detection, and assess the utility of repeating a BAL within 30 days. The microorganisms isolated from BAL samples from both auto-and allo-SCT recipients are listed in Table 2 .


id: cord-016936-cl3kezes
author: Poletti, Venerino
title: Procedure diagnostiche invasive nelle malattie infiltrative diffuse del polmone
date: 2007
extension: .txt
mime: text/plain
words: 6987
sentence: 347
flesch: 34
cache: cache/cord-016936-cl3kezes.txt
txt: txt/cord-016936-cl3kezes.txt
summary:
  i risultati della biopsia, ma nel 69% di quelli con una dia- gnosi specifica, e la sopravvivenza a 30 e 90 giorni era aumentata in quelli con una diagnosi polmonare specifica piuttosto che non specifica È rilevante che molti di questi disordini siano caratterizzati da un punto di vista patologico dall'accumulo di cellule diagnostiche o materiale extracellulare negli spazi alveolari (il cosiddetto gruppo delle malattie da riempimento alveolare) e da un punto di vista radiologico da opacità alveolari o aree a vetro smerigliato all'HRCT.


id: cord-335709-pta3nzz9
author: Murphy, Caitlin N.
date: 2020-06-24
extension: .txt
mime: text/plain
words: 8022
sentence: 285
flesch: 35
cache: cache/cord-335709-pta3nzz9.txt
txt: txt/cord-335709-pta3nzz9.txt
title:
  Multicenter Evaluation of the BioFire FilmArray Pneumonia/Pneumonia Plus Panel for Detection and Quantification of Agents of Lower Respiratory Tract Infection

summary:
  This study assessed the performance of the BioFire FilmArray Pneumonia Panel (PN panel) and Pneumonia Plus Panel (PNplus panel), an FDA-cleared sample-to-answer assay that enables the detection of viruses, atypical bacteria, bacteria, and antimicrobial resistance marker genes from lower respiratory tract specimens (sputum and bronchoalveolar lavage [BAL] fluid). The BioFire FilmArray Pneumonia Panel (PN panel) and Pneumonia Plus Panel (PNplus panel) (BioFire Diagnostics, LLC, Salt Lake City, UT) were designed to provide a means of rapidly detecting nucleic acids from common agents of community-and hospital-acquired lower respiratory tract infections ( Table 1 ).


id: cord-002823-n55xvwkf
author: Halstead, E. Scott
date: 2018-01-05
extension: .txt
mime: text/plain
words: 8101
sentence: 289
flesch: 38
cache: cache/cord-002823-n55xvwkf.txt
txt: txt/cord-002823-n55xvwkf.txt
title:
  GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization

summary:
  BAL airway macrophages were sorted using the gating strategy described in Fig. 4a and next generation RNA-sequencing was used to profile the complete transcriptome data of AMs (a, orange bars) and EMs (b, blue bars) at 8 dpi, the time point at which the survival curves diverge (n = 5 mice per group). BAL airway macrophages were sorted and RNA-sequencing was performed to compare the gene expression between IAV-infected LM (n = 5 mice) and DTGM (n = 5 mice) treated with doxycycline at 8 dpi.


id: cord-275757-zpblaa36
author: Buchan, Blake W.
date: 2020-06-24
extension: .txt
mime: text/plain
words: 10753
sentence: 353
flesch: 25
cache: cache/cord-275757-zpblaa36.txt
txt: txt/cord-275757-zpblaa36.txt
title:
  Practical Comparison of the BioFire FilmArray Pneumonia Panel to Routine Diagnostic Methods and Potential Impact on Antimicrobial Stewardship in Adult Hospitalized Patients with Lower Respiratory Tract Infections

summary:
  Potential antibiotic adjustments based on PN panel results were considered inappropriate if results between PN panel and SOC were discordant (see Table S1 and Materials and Methods for specific criteria). Clinical, demographic, and laboratory data were abstracted from the laboratory information system (LIS) and electronic health record (EHR) at each clinical site by individuals who were not involved in either clinical testing or PN panel testing of specimens and who were blinded to PN panel results.


id: cord-302403-kahi8cbc
author: Miller, Robert F.
title: Pulmonary Infections
date: 2009-05-15
extension: .txt
mime: text/plain
words: 18178
sentence: 832
flesch: 41
cache: cache/cord-302403-kahi8cbc.txt
txt: txt/cord-302403-kahi8cbc.txt
summary:
  The course of HIV infection can be divided clinically into several distinct periods: Acquisition of the virus Seroconversion, with or without a clinical illness (primary HIV infection) Tuberculosis HIV infection is associated with at least a 40-fold increased risk of an individual having active tuberculosis develop compared with noninfected subjects.


id: cord-332298-ig1j5z07
author: Couetil, Laurent
title: Equine Asthma: Current Understanding and Future Directions
date: 2020-07-30
extension: .txt
mime: text/plain
words: 15567
sentence: 524
flesch: 30
cache: cache/cord-332298-ig1j5z07.txt
txt: txt/cord-332298-ig1j5z07.txt
summary:
  -reported coughing and nasal discharge are associated with clinical findings, arterial oxygen tension, mucus score and bronchoprovocation in horses with recurrent airway obstruction in a field setting Physiological measurements and prevalence of lower airway diseases in trotters with dorsal displacement of the soft palate The occurrence of dynamic structural disorders in the pharynx and larynx, at rest and during exercise, in horses diagnosed with mild and moderate equine asthma (inflammatory airway disease) Indeed, 19 years ago, Robinson et al. found that even in horses with historical severe EA, clinical score failed to reflect low-grade airway obstruction, and suggested that without easily used, field-accessible testing equipment, lower airway disease would go underdiagnosed (53) .


# ent

id: cord-016732-mdyu69ca
sid: 32
eid: 5
type: ORG
entity:
  idiopatiche e nella fase organizzativa del danno alveolare diffuso possono mostrare atipie tali da essere


id: cord-017123-g1m1y38x
sid: 12
eid: 1
type: ORG
entity:
  nell'adulto la metodica più comunemente accettata per eseguire il bal è quella di instillare cinque aliquote di


id: cord-017123-g1m1y38x
sid: 60
eid: 7
type: ORG
entity:
  della parete bronchiale è comunque facilmente verificabile visivamente durante l'esecuzione della metodica


id: cord-017123-g1m1y38x
sid: 80
eid: 2
type: ORG
entity:
  l'aumento di una quota cellulare dovrebbe poi causare anche l'aumento consequenziale della cellularità totale


id: cord-017123-g1m1y38x
sid: 88
eid: 10
type: ORG
entity:
  endoscopia bronchiale pediatrica gli anticorpi monoclonali si usano anche nella diagnosi dell'istiocitosi polmonare


id: cord-016936-cl3kezes
sid: 45
eid: 2
type: ORG
entity:
  distinguere infiltrazioni neoplastiche del polmone da coinvolgimento polmonare di malattie collageno-vascolari o vasculiti


id: cord-016936-cl3kezes
sid: 61
eid: 3
type: ORG
entity:
  cambiamenti iperplastici/displastici dei pneumociti di tipo ii e le indagini microbiologiche negative


id: cord-016936-cl3kezes
sid: 95
eid: 1
type: ORG
entity:
  controllo della eventuale emorragia con l'aspiratore e con il palloncino gonfiato alterazioni patologiche non


id: cord-016936-cl3kezes
sid: 157
eid: 3
type: ORG
entity:
  casi nella nostra esperienza (e di solito nei casi con tipiche lesioni nodulari e cistiche all'hrct)


id: cord-016936-cl3kezes
sid: 177
eid: 1
type: PERSON
entity:
  la polmonite da ipersensibilità nel suo stadio subacuto è istologicamente definita dalla presenza di infiltrato linfocitico peribronchiolare


