Bibliography

This is an automatically generated bibliography describing the content of this study carrel.

1. cord-000843-e1bn79ui
   • author: None
   • title: ECR 2011 Book of Abstracts - A - Postgraduate Educational Programme
   • date: 2011-03-01
   • words: 91300
   • flesch: 40
   • summary: Both conditions are easily discernible with CT imaging. CT perfusion imaging is a quantitative technique that employs rapid sequences of CT images after bolus administration of intravenous contrast material to measure a range of physiological processes related to the microvasculature of tissues.
   • keywords: abdomen; abdominal; ability; ablation; abnormalities; absence; abuse; accepted; access; accuracy; accurate; acquisition; active; activity; acute; adc; addition; address; adenocarcinoma; adequate; adjacent; administration; adnexal; adults; advanced; advanced imaging; advantages; agents; aim; air; airways; algorithms; alterations; alternative; analysis; anatomic; anatomy; aneurysms; angiogenesis; angiography; anomalies; answer; anterior; aortic; appearance; applications; approach; appropriate; appropriate imaging; areas; artefacts; arterial; arteries; artery; aspects; assessment; associated; attenuation; audit; availability; available; aware; axial; basic; benefit; benign; best; better; biological; biology; biomarkers; biopsy; blood; bmls; body; bone; bowel; brain; brain imaging; brain tumour; breast cancer; breast imaging; breast mri; bronchiolitis; cad; calcifications; cancer; cancer patients; capabilities; carcinoma; cardiac; cardiac ct; cardiovascular; care; cartilage; cases; cause; cavity; cell; cellular; central; cerebral; certain; challenge; changes; characterisation; chemical; chemotherapy; chest; chest ct; childhood; children; choice; chronic; classification; classified; clinical; clinical findings; clinical imaging; clinical information; clinical mri; clinical practice; clinical studies; clinical trials; clinical use; clinician; close; coil; collaboration; colonic; colonoscopy; colorectal; colour; combination; combined; common; communication; community; comparison; complete; complex; complications; components; comprehensive; computer; concepts; conclusion; conditions; congenital; consequences; context; contrast; control; conventional; conventional imaging; coronary; correct; correlation; cortex; cost; countries; course; crc; criteria; critical; cross; crucial; ct angiography; ct colonography; ct examination; ct findings; ct images; ct imaging; ct perfusion; ct scan; ct scanners; ct techniques; ct technology; cta; ctc; current; cystic; cysts; daily; data; date; dce; decade; decision; decrease; dedicated; deep; density; design; detail; detailed; detection; detector; development; devices; diabetes; diagnosis; diagnostic imaging; diameter; differences; different; different imaging; differential; differential diagnosis; differentiation; difficult; diffuse; diffusion; digital; dilatation; dimensional; direct; disadvantages; discussion; disease; disorders; distant; distribution; doppler; dose; drainage; drug; dual; dwi; dynamic; dynamic imaging; dysfunction; early; ecg; echo; effective; effectiveness; effects; efficient; effusion; elderly; embolisation; emergency; emission; emphasis; end; endovascular; energy; energy ct; enhanced; enhancement; entities; environment; eortc; epilepsy; equipment; errors; essential; established; estimation; european; evaluation; evar; evidence; examination; examples; excellent; expected; experience; expert; expiratory; exposure; extension; extent; external; factors; failure; false; familiar; fast; fat; fdg; fibrosis; field; findings; floor; flow; fluid; fmri; focus; foetal; follow; following; forms; fractures; free; frequent; functional imaging; functional mri; future; gadolinium; gain; general; good; grade; gradient; great; greater; group; growth; guidance; guidelines; haemorrhage; hand; head; health; heart; help; helpful; hepatic; high; higher; hip; histologic; history; hospital; hours; hrct; human; identification; images; imaging; imaging appearance; imaging approach; imaging criteria; imaging evaluation; imaging features; imaging findings; imaging methods; imaging modality; imaging procedures; imaging protocols; imaging reporting; imaging sequences; imaging strategies; imaging studies; imaging techniques; imaging test; imaging tool; impact; implementation; important; important clinical; important role; improved; improvement; incidence; increase; indications; indirect; individual; induced; infants; infection; inflammation; inflammatory; influence; information; initial; initial imaging; injuries; injury; insight; intensity; interest; internal; international; interpretation; interstitial; interventional; intracranial; intravenous; introduction; invasive; invasive imaging; investigation; involved; involvement; iodine; ionising; ischaemic; issues; key; knowledge; known; lack; large; lateral; lead; leading; learning; lecture; lesions; level; life; like; likely; limitations; limited; limits; line imaging; linear; literature; liver; lobe; local; location; long; loss; lower; lung; lymph; lymphoma; magnetic; main; major; majority; making; malformations; malignant; mammography; management; mandatory; margin; marrow; mass; masses; material; matter; mdct; means; measurements; measures; mechanism; mediastinum; medical; medical imaging; medicine; medium; mesenteric; metabolic; metastases; middle; modalities; models; modern; molecular imaging; monitoring; months; morbidity; morphological; morphology; mortality; motion; mr imaging; mra; mrcp; mri; mri findings; mrs; multidetector; multidisciplinary; multiple; muscle; myocardial; nature; near; necessary; neck; necrosis; need; needle; negative; neuroimaging; neurological; new; new imaging; new techniques; nodes; nodules; noise; non; noninvasive; normal; novel; nuclear; number; numerous; objectives; obstruction; oedema; oncological; oncology; opacity; operation; optimal; optimisation; options; order; organ; origin; osteomyelitis; outcome; ovarian; overall; overview; paediatric; pain; painful; pancreas; pancreatic; pancreatitis; panel; parallel imaging; parameters; parenchymal; particular; parts; pathological; pathologies; pathology; patients; pattern; pelvic; percutaneous; perforation; performance; perfusion; perfusion imaging; period; peripheral; peritoneal; permeability; perspective; pet; phase; physical; physiological; pitfalls; planning; play; pleural; pneumonia; point; polyps; poor; population; portal; position; positive; possibilities; possibility; possible; post; posterior; postoperative; potential; practical; practice; precise; predictive; pregnancy; pregnant; preoperative; preparation; presence; presentation; prevalence; primary; primary imaging; principles; prior; probes; problem; procedures; process; processes; processing; prognosis; progression; promising; proper; properties; prostate; pulmonary; purpose; quality; quantification; quantitative; question; radiation; radiofrequency; radiographers; radiography; radiological; radiological imaging; radiologist; radiology; radiotherapy; rads; range; rapid; rare; rates; ray; ray imaging; recent; recognition; recurrences; recurrent; reduced; reduction; reference; regional; related; relationship; relative; relevant; reliable; renal; repair; report; reported; reporting; required; requirements; research; residual; resolution; resolution ct; resonance imaging; respect; response; responsible; results; revascularisation; review; right; risk; robust; role; room; routine; rupture; sad; safety; sagittal; scan; scanners; scanning; sclerosis; screening; second; secondary; sectional imaging; selected; selection; sensitive; sensitivity; sequences; session; setting; severe; severity; shape; shift; short; signal; significant; signs; similar; simple; simulation; single; site; situations; size; skeletal; skills; small; soft; software; solid; source; space; spatial; special; specific; specific imaging; specificity; spectroscopy; spectrum; spine; spread; stages; staging; standard; standard imaging; state; stenosis; step; strategies; strategy; strength; stroke; structures; studies; study; subsequent; substantial; success; superior; supply; support; surgeons; surgery; surgical; surveillance; survival; susceptibility; symptoms; syndrome; system; systemic; tailored; talk; targeted; task; team; technical; technological; technologies; technology; teleradiology; temporal; tendon; tensor imaging; term; test; therapeutic; therapies; therapy; thickening; thin; thoracic; thoracic ct; threatening; time; tissue; today; tomography; tool; torsion; tracers; tract; training; transplantation; trauma; traumatic; treatment; treatment response; trials; tuberculosis; tumour; tumour imaging; tumour response; type; typical; ultrasonography; ultrasound; underlying; understanding; upper; uptake; urinary; use; useful; validation; valuable; value; variants; variety; vascular; venous; vessels; virtual; visualisation; vital; vivo; volume; wall; water; way; weighted; white; wide; women; work; working; years; young
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2. cord-001221-due9tloa
   • author: None
   • title: ECR 2014, Part A
   • date: 2014-02-27
   • words: 107894
   • flesch: 38
   • summary: On CT imaging, thermal ablation areas are well circumscribed and oval shaped. MR imaging allows earlier detection of residual liver tumour than CT imaging.
   • keywords: abdomen; abdominal; ability; ablation; ablation imaging; abnormalities; abnormality; absence; academic; accepted; access; account; accuracy; accurate; acquisition; action; active; activities; activity; acute; adc; additional; additional imaging; adequate; adjuvant; administration; adrenal; adults; advanced; advanced imaging; advantages; adverse; affected; agents; aim; air; algorithms; allow; alternative; analysis; anatomical; anatomical imaging; anatomy; angiography; angioplasty; annual; anomalies; aorta; aortic; appearance; applications; applied; approach; appropriate; appropriate imaging; area; artefacts; arterial; arteries; artery; asl; aspects; assessment; associated; attention; audience; audit; auditory; availability; available; aware; axial; base; basic; beam; beam ct; benefits; benign; best; better; biliary; biological; biology; biopsies; biopsy; bleeding; blood; body; bone; bowel; brain; brain imaging; breast cancer; breast imaging; breast mri; calcifications; canal; cancer; cancer patients; candidates; carcinoma; cardiac; cardiac ct; cardiovascular; care; careful; carotid; cartilage; cases; cause; cbct; cbf; cell; cellular; centers; central; centres; cerebral; certain; ceus; challenges; challenging; changes; characterisation; chemotherapy; chest; chest imaging; children; choice; chronic; classification; clinical; clinical applications; clinical audit; clinical ct; clinical diagnosis; clinical evaluation; clinical findings; clinical information; clinical practice; clinical presentation; clinical radiology; clinical trials; clinical use; clinicians; close; cmr; cns; cognitive; collections; colorectal; combination; combined; common; common imaging; communication; comparison; complete; complex; complicated; complications; components; composition; comprehensive; comprehensive imaging; compression; concepts; concern; conditions; cone; congenital; connectivity; consideration; context; continuous; contrast; control; conventional; conventional imaging; copd; cord; core; coronal; coronary; coronary ct; correct; correlation; cortical; cost; countries; country; course; cranial; criteria; critical; cross; crosssectional imaging; crucial; ct angiography; ct findings; ct images; ct imaging; ct perfusion; ct scan; ct studies; ct techniques; cta; cuff; current; current imaging; cystic; cysts; daily; damage; data; date; dbt; dce; death; decade; decision; dedicated; deep; definition; degree; delivery; dementia; density; department; dependent; description; design; detailed; detection; development; devices; diabetic; diagnosis; diagnostic imaging; diameter; dicom; differences; different imaging; differential; differential diagnosis; differentiation; difficult; diffuse; diffusion; diffusion imaging; digital; dilatation; dimensional; direct; discussion; disease; disorders; displays; dissection; distribution; dose; dose ct; drug; dvt; dwi; dynamic; dysfunction; e.g.; earlier; early; easy; ecg; echo; education; effective; effective imaging; effectiveness; effects; efficacy; efficient; elastography; embolisation; emergencies; emergency; emphasis; endoscopy; endovascular; endovascular treatment; energy; enhancement; entities; environment; equipment; errors; esr; essential; established; european; evaluation; evidence; evolving; examination; examples; excellent; expected; experience; expertise; exposure; expression; extension; extent; external; facial; factors; failure; false; familiar; fast; fat; fatty; fdg; features; fibrosis; field; final; fistulas; flow; fluid; fluoroscopy; focus; focused; follow; following; foot; fractures; free; frequent; functional imaging; future; gadolinium; gastric; gastrointestinal; general; ggo; glass; goal; good; grade; grafts; great; greater; ground; group; growth; guidance; guidelines; haemorrhage; hand; hcc; head; health; healthcare; heart; help; helpful; high; higher; history; hospital; hours; hrct; human; hybrid imaging; hypertension; identification; illustrated; image; imaging; imaging appearances; imaging approach; imaging aspects; imaging biomarkers; imaging characteristics; imaging criteria; imaging data; imaging evaluation; imaging examinations; imaging features; imaging findings; imaging information; imaging methods; imaging modalities; imaging pattern; imaging probes; imaging procedures; imaging professionals; imaging protocols; imaging reporting; imaging research; imaging signs; imaging strategies; imaging studies; imaging systems; imaging techniques; imaging technologies; imaging tools; imaging workup; impact; implementation; important; important imaging; important role; improved; improvement; incidence; incidental; increased; indeterminate; index; indications; individual; induced; infection; inflammation; inflammatory; influence; information; initial; initial imaging; injuries; injury; institutions; integrated; integration; intensity; interest; internal; international; interpretation; interstitial; interventional; interventional radiology; intra; introduction; invasion; invasive; invasive imaging; investigation; involved; involvement; ischaemic; issues; joint; key; knowledge; known; labelling; laboratory; lack; large; laryngeal; lateral; learning; lecture; left; lesions; level; life; like; likely; limb; limitations; limited; line imaging; literature; liver; local; location; long; longer; loss; lower; lung; lung cancer; lung disease; lymph; lymphoma; magnetic; main; main imaging; major; majority; making; malignancies; malignant; mammography; management; mandatory; manifestations; maps; marrow; mass; masses; matter; mdct; means; measurements; measures; measuring; mechanisms; media; mediastinal; medical imaging; medicine; medium; members; metabolic; metastases; metastatic; mimic; modality; models; modern; molecular imaging; monitoring; months; morbidity; morphological; morphological imaging; morphology; mortality; motion; mpi; mr imaging; mra; mre; mri; mri techniques; multidetector; multidisciplinary; multimodality imaging; multiple; muscle; myocardial; nature; near; necessary; neck; neck imaging; necrosis; necrotic; need; needed; needle; negative; neoadjuvant; neoplasms; neoplastic; nerve; nets; network; neuroendocrine; neuroimaging; neurological; neurovascular; new; nodes; nodules; non; nonspecific; normal; novel; nuclear imaging; number; numerous; obesity; objectives; obstruction; occlusion; oedema; oesophageal; offer; oncologic; oncologic imaging; oncology; open; operative; opportunity; optimal; optimal imaging; optimisation; options; orbital; organ; origin; outcome; outside; ovarian; overall; overview; paediatric; paediatric imaging; pain; pancreas; pancreatic; pancreatitis; parallel; parameters; parenchyma; partial; particular; parts; past; pathological; pathologies; pathology; pathophysiology; pathways; patient care; patient dose; patient management; patients; pattern; pelvic; percutaneous; performance; perfusion imaging; peripheral; peritoneal; personal; pet; pet imaging; phase; physical; physicians; physiological; pitfalls; place; placement; planning; play; pneumonia; points; poor; population; positioning; positive; possibilities; possibility; possible; post; posterior; postoperative; postoperative imaging; potential; practical; practice; precise; precision; predictive; preoperative; presence; presentation; pressure; prevalence; previous; primary; primary imaging; principles; prior; problems; procedures; process; processes; processing; professional; prognostic; progression; project; promising; proper; properties; prostate; protection; protocols; pseudo; pulmonary; purpose; pwi; quality; quantification; quantitative; quantitative imaging; questions; radiation; radiation dose; radiofrequency; radiographs; radiological; radiological imaging; radiologists; radiology; radiotherapy; rads; range; rapid; rare; rates; ray; reading; recent; receptor; recist; recognition; recommendations; reconstruction; rectal; recurrence; reduced; reduction; reference; regard; region; related; relationship; relative; relevant; reliable; remains; renal; reporting; reports; requirements; research; resection; residual; resolution; resonance imaging; respect; respiratory; response; responsible; restricted; results; revascularisation; review; right; risk; risk patients; robust; role; room; rotator; routine; rule; rupture; safety; sampling; scan; scanners; scanning; scientific; scintigraphy; scoring; screening; second; secondary; sectional imaging; selection; sensitive; sensitivity; sequences; series; services; session; setting; severe; severity; short; shows; signal; significant; signs; similar; simple; single; sinus; site; situations; size; skills; skin; skull; small; social; societies; society; soft; software; solid; sophisticated; source; space; spatial; special; specialists; specific; specific imaging; specificity; spect; spectroscopy; spectrum; spinal; spine; spread; staff; stage; staging; standard; standard imaging; standardisation; standardised; status; stenosis; steps; strategies; strategy; strengths; stroke; structures; studies; study; subsequent; success; successful; superior; support; surgery; surgical; surveillance; survival; symptomatic; symptoms; syndrome; systematic; systems; tablets; talk; targeted; targets; task; team; technical; technological; technology; teleradiology; templates; temporal; tensor imaging; term; testing; tests; therapeutic; therapies; therapy; thermal; thin; thoracic; thrombolysis; thyroid; time; tissue; today; tomography; tool; total; tract; traditional; training; trauma; traumatic; treated; treatment; treatment imaging; treatment response; trials; true; tumors; tumour; tumour imaging; tumour response; tumour size; tumoural; type; typical; ultrasonography; ultrasound; ultrasound imaging; underlying; understanding; unique; units; upper; uptake; use; useful; user; uterine; validation; value; variability; variable; variants; variations; variety; vascular; vasculitis; venous; ventricular; vessel; viable; visible; visualisation; vital; vivo; volume; wall; way; weighted; weighted imaging; white; wide; women; work; workflow; workup; world; worldwide; wrist; years; young; zone
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3. cord-001687-paax8pqh
   • author: Henkel, Jan
   • title: Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective
   • date: 2013-09-25
   • words: 15793
   • flesch: 22
   • summary: As summarised above, adequate porosity and pore size is crucial for bone tissue engineering scaffolds in order to allow sufficient vascularisation and enable a supply of body fluids throughout the TEC. There are currently thousands of research papers and reviews available on bone tissue engineering, but there is still a major discrepancy between scientific research efforts on bone tissue engineering and the clinical application of such strategies.
   • keywords: activity; additive; adhesion; advances; allografts; animal; animal models; applications; approaches; area; aspirator; autologous; autologous bone; available; bedside; bench; bioactive; biodegradable; biological; biomaterials; body; bone; bone defects; bone engineering; bone formation; bone graft; bone grafting; bone regeneration; bone substitute; bone tissue; bridging; bsm; calcium; cancellous; cells; ceramics; challenges; characteristics; chemical; clinical; collagen; combination; complex; composite; concept; conditions; constructs; control; cortical; cortical bone; critical; current; custom; defect; degradation; design; development; differentiation; dimensional; engineering research; engineering scaffolds; example; fabrication; factors; field; figure; formation; fracture; function; fusion; future; general; gold; graft; grafting; group; growth; harvesting; healing; high; human; hydroxyapatite; implantation; implants; induced; influence; introduction; irrigator; large; layer; level; limited; load; long; manufacturing; marrow; masquelet; materials; matrix; mechanical; mechanical properties; medicine; membrane; mesenchymal; methods; models; months; mpcl; musculoskeletal; natural; necessary; new; new bone; non; novel; number; order; organic; orthopaedic; osteogenesis; osteogenic; osteoinductive; patient; phosphate; pmma; polycaprolactone; pore; porosity; porous; potential; practice; preclinical; procedures; process; products; proliferation; properties; proteins; prototyping; rapid; reamer; recent; reconstruction; regeneration; remodelling; repair; replacement; research; response; results; review; risk; role; scaffold; scale; scientific; second; segmental; sheep; significant; similar; site; size; skeletal; skull; small; solid; spacer; specific; spinal; spine; stability; standard; strategies; structure; studies; study; substitute; sufficient; support; surface; surgery; surgical; system; tcp; techniques; technology; tibial; time; tissue; tissue engineering; tissue regeneration; today; trabecular; translation; treatment; use; vascularisation; vitro; vivo; years
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4. cord-002626-jzwwses4
   • author: Kaul, Karen L.
   • title: The Case for Laboratory Developed Procedures: Quality and Positive Impact on Patient Care
   • date: 2017-07-16
   • words: 14833
   • flesch: 34
   • summary: [79] [80] [81] Instrumentation from Thermo Fisher (Thermo Fisher Life-Technologies, Carlsbad, CA, USA) and Illumina (Illumina, San Diego, CA, USA), the Personal Genome Machine (PGM), and MiSeq, have made NGS suitable for routine clinical laboratory testing. Laboratory testing for FX includes sizing the number of repeats as well as methylation analysis and has been available for clinical diagnostic and carrier status testing for over 20 years.
   • keywords: abl1; accuracy; accurate; additional; american; analysis; anti; appropriate; approval; april; assays; assessment; association; available; bcr; biopsy; blood; braf; busulfan; cancer; cap; cardiomyopathy; care; carriers; cases; cause; cell; characteristics; clia; clinical; clinical laboratories; college; colorectal; common; companion; comprehensive; consensus; cost; criteria; critical; current; cytomegalovirus; data; death; detection; development; diagnosis; disease; disorders; dna; drug; early; efforts; egfr; encephalitis; epilepsy; ethylene; evaluation; examples; exome; family; fda; gene; generation; genetic; genome; genomic; glycol; group; guidelines; health; high; hpv; hsv; human; identification; impact; important; improvement; infection; information; instability; interlaboratory; international; interpretation; kinase; kit; kras; laboratories; laboratory; lack; ldps; leukemia; levels; life; limited; load; lung; management; marrow; mass; materials; medical; medicine; metastatic; methods; microsatellite; molecular; mortality; msi; multiple; mutations; need; negative; new; ngs; oncology; ongoing; outcomes; oversight; panel; pathologists; pathology; patient care; patients; pcr; performance; phenotype; plasma; positive; practice; presence; procedures; process; proficiency; public; pvan; quality; rapid; recent; recipients; reference; repeat; reporting; requirements; response; results; review; risk; routine; samples; sequence; sequencing; serum; single; small; society; specific; specimens; spectrometry; spectrum; standardization; standards; states; studies; study; syndrome; system; targeted; technology; testing; testosterone; tests; therapeutic; therapy; thyroid; time; tissue; transplant; transplantation; treatment; tumor; types; united; use; v600e; validation; variants; viral; virus; years; zika
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5. cord-003316-r5te5xob
   • author: Balloux, Francois
   • title: From Theory to Practice: Translating Whole-Genome Sequencing (WGS) into the Clinic
   • date: 2018-12-17
   • words: 7342
   • flesch: 29
   • summary: However, a micro-costing analysis covering laboratory and personnel costs estimated the cost of clinical WGS to £481 per M. tuberculosis isolate versus £518 applying standard methods, representing relatively marginal cost savings but with significant time savings [63] . Somewhat ironically, the extremely rich information of WGS data, with every genome being unique, generates problems of its own.
   • keywords: academic; accessory; amr; analysis; antibiotic; antimicrobial; applications; approaches; aureus; bacterial; bioinformatics; challenges; characterization; classification; clinical; clinical microbiology; complex; costs; culture; current; data; databases; diagnostics; different; disease; diversity; dna; drug; environment; evolution; example; figure; future; genes; genetic; genome; genome sequencing; health; high; hospital; host; human; identification; implementation; infections; inference; information; isolate; key; laboratory; large; level; likely; major; metagenomic; methods; microbial; microbiology; mycobacterium; near; need; new; organisms; outbreak; output; pathogen; patients; phenotype; phylogenetic; pipeline; pneumoniae; possible; potential; prediction; presence; present; principle; problem; profiling; public; rapid; raw; real; reconstruction; relevant; research; resistance; review; routine; samples; sequence; sequencing; setting; single; species; specific; standard; staphylococcus; strain; study; surveillance; time; tools; traditional; transmission; tuberculosis; typing; uptake; use; virulence; viruses; wgs
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6. cord-003878-nmyyt51x
   • author: de Campos, Fernando Peixoto Ferraz
   • title: What does the future hold?
   • date: 2012-03-30
   • words: 1348
   • flesch: 52
   • summary: If clinical autopsy rates continue to decline, the future practice of medicine will be blind to many adverse consequences of clinical actions and omissions. Paradoxically, community doctors generally show that they appreciate receiving autopsy reports and that, in a high proportion of cases, the findings are unexpected and could influence their future clinical practice.
   • keywords: accuracy; autopsies; autopsy; cases; clinical; context; death; decline; discrepancies; diseases; family; future; hospital; imaging; knowledge; medical; medicine; mortem; need; number; pathologists; post; practice; study; teaching
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7. cord-007321-7gi6xrci
   • author: Chow, Anthony W.
   • title: Evaluation of New Anti-Infective Drugs for the Treatment of Respiratory Tract Infections
   • date: 1992-11-17
   • words: 16092
   • flesch: 29
   • summary: In phase 2 and 3 trials, study patients should be stratified according to major host factors (e.g., history and duration of smoking). Clinical studies should include patients of different age groups, since the clinical manifestations of group A streptococcal pharyngitis and tonsillitis may vary with age of the patient.
   • keywords: absence; active; activity; acute; acute sinusitis; addition; adm; adults; agents; antimicrobial; antimicrobial therapy; aom; appropriate; aspirates; aspiration; assessment; aureus; available; bacilli; bacterial; basis; blind; blood; bronchitis; cases; catarrhalis; cause; chest; children; chronic; chronic sinusitis; clinical; clinical evaluation; clinical failure; clinical response; common; community; completion; complications; concentrations; conditions; control; cough; criteria; culture; cure; data; days; definition; design; desirable; detection; development; diagnosis; direct; disease; double; drug; duration; ear; effective; efficacy; endoscopic; enrollment; eradication; erythromycin; etiologic; etiology; evaluation; evidence; exacerbations; failure; fever; findings; fluid; follow; following; function; general; gram; group; guidelines; hematologic; hemolytic; hepatic; history; hospital; host; hours; identification; important; improvement; infants; infection; infective; influenzae; initial; initiation; isolates; isolation; laboratory; lack; lactamase; legionella; lower; major; management; maxillary; media; mee; microbiologic; microbiologic response; middle; months; nasal; necessary; negative; new; nosocomial; oral; organism; otitis; outcome; pain; pathogens; patients; penicillin; persistence; pharyngitis; phase; placebo; pleural; pneumonia; possible; potential; presence; present; pulmonary; puncture; purulence; randomized; rate; recurrence; regimens; relapse; renal; resolution; respiratory; response; results; rheumatic; role; s. pneumoniae; secretions; shouldbe; signs; sinuses; sinusitis; species; specific; specimens; sputum; standard; standardized; states; strains; streptococcal; studies; study; suppurative; susceptibility; symptoms; testing; tests; therapy; throat; time; tonsillitis; tract; treatment; trial; tympanocentesis; upper; use; value; vitro; volume; weeks; years
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8. cord-007331-wccmeaep
   • author: Orcutt, Connie J.
   • title: Emergency and Critical Care of Ferrets
   • date: 2017-04-20
   • words: 9981
   • flesch: 41
   • summary: Beta-adrenergic blockers (atenolol, 6.25 mg/ferret PO q24h) or calcium channel antagonists (diltiazem, 3.75 to 7.5 mg/ferret PO q12h) are most commonly used to relax the myocardium and to improve diastolic filling in cases of hypertrophic cardiomyopathy.l3, 54 Administer fluid therapy judiciously in ferrets with cardiac disease to avoid fluid overload and subsequent development of pulmonary edema. Emergency situations involving ferrets are most often caused by gastrointestinal disease, neoplasia, cardiac disease, or endocrinopathy.
   • keywords: abdominal; abnormal; access; additional; administer; administration; adrenal; adrenocortical; affected; age; anemia; anesthesia; animals; anorexia; antibiotic; author; bacterial; blood; bodies; body; bowel; bun; cardiac; care; cases; catheter; catheterization; cats; cause; cbc; chronic; clinical; clinical signs; collapse; common; critical; culture; days; debilitated; definitive; dehydration; dextrose; diagnosis; diarrhea; differential; disease; dose; effusion; elevated; esophageal; estrogen; evaluation; evident; examination; feeding; ferrets; fluid; foreign; gagging; gastric; gastrointestinal; gauge; glucose; heart; hepatic; hypoglycemia; infection; influenza; initial; insulinoma; jugular; kg po; lateral; lethargy; levels; loss; male; mass; mediastinal; medications; melena; metabolic; monitor; mustelae; needle; neoplasia; normal; obstruction; patient; pcv; peripheral; pet; place; pleural; pneumonia; pneumothorax; prednisone; prostatic; protocols; pulmonary; q12h; radiographs; recumbency; results; risk; section; sensitivity; serum; severe; signs; similar; skin; small; specific; supplementation; supportive; surgical; syringe; tissue; treatment; tube; ultrasound; uncommon; urethral; urinary; urine; use; vein; volume; vomiting; weakness; weight
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9. cord-009664-kb9fnbgy
   • author: None
   • title: Oral presentations
   • date: 2014-12-24
   • words: 71226
   • flesch: 44
   • summary: Resistance to penicillin, clindamycin and tetracycline fluctuated over time at~75%, 4−8% and 2−10% respectively. The median expected power was 10.0% (IQR, 7.2−13.6%) for a risk ratio for mortality of 0.85 between the compared groups; 14.7% (IQR, 10.6−21.8%) for a risk ratio of 0.80; and 7.9% (IQR, 6.3−10.2%) for a reduction in mortality from 30% to 25%.
   • keywords: 16s; abar1; ability; absence; account; acid; acinetobacter; acquisition; active; activity; acute; addition; adherence; administration; admission; adult; adverse; aeruginosa; aetiology; affected; agar; age; agents; aim; alternative; america; ampc; amt; anaerobes; anaerobic; analysis; animals; antibiotic; antibiotic resistance; antibodies; antibody; antifungal; antigen; antimicrobial; antimicrobial resistance; antiviral; aom; approach; appropriate; areas; assay; assessment; associated; association; aureus; available; average; azm; background; bacteraemia; bacterial; bacteriophages; bal; baseline; basis; baumannii; benefit; best; beta; better; biofilm; blactx; blakpc; blaoxa-58; blood; brain; broad; burden; cancer; candida; candidiasis; cap; care; cases; cassette; catheter; cause; cdi; ceftazidime; ceftriaxone; cells; central; centre; cephalosporins; cfu; changes; characterised; characteristics; children; chlorhexidine; choice; chromogenic; chromosomal; chronic; cihhv-6; ciprofloxacin; class; classes; clindamycin; clinical; clinical isolates; clinical samples; clinicians; clonal; clone; clostridium; closure; clsi; clusters; cmv; cohort; coli; collection; colonisation; colonised; combination; combined; common; community; comparable; comparison; complex; concentrations; concern; conclusion; conditions; confidence; confirmed; considerable; contact; contamination; contrast; control; conventional; correlation; cost; countries; course; coverage; cpt; critical; cross; csf; ctx; culture; cure; current; daily; damage; data; days; decrease; dengue; density; department; design; detection; determinants; developed; development; dfrk; diagnosis; diarrhoea; differences; different; difficile; difficult; direct; disease; dissemination; distinct; distribution; diversity; dna; dose; double; drug; drug resistance; duration; early; eastern; ebv; echinocandins; education; effect; effective; effectiveness; efficacy; efflux; eia; elbow; electrophoresis; elements; emergence; empiric; encoding; end; endemic; enterobacteriaceae; environmental; enzyme; epidemic; epidemiological; epidemiology; epidermidis; episodes; esbl; established; etest; europe; european; events; evidence; evolution; examination; exhibit; experimental; exposure; expression; extended; extent; factors; faecal; failure; family; farm; features; fever; field; figure; findings; fluconazole; fluid; fold; following; france; free; frequency; frequent; functional; future; gas; gbs; gel; gene; general; genetic; genome; genomic; genotype; germany; giemsa; global; good; gram; great; greater; greece; group; growth; guidelines; hai; half; hantaviruses; harboured; hbv; hcv; head; health; healthcare; heart; help; hepatitis; hev; high; higher; highest; history; hiv; homes; hospital; hospitalisation; host; hours; hpv; human; hybridisation; icu; identification; igg; illness; imipenem; immune; immunisation; immunity; impact; important; improved; improvement; incidence; increase; individual; infected; infection control; infections; inflammation; inflammatory; influenza; information; inhibitors; initial; insights; integron; intensive; interest; intervention; interviews; introduction; invasive; investigation; islands; isolates; isolation; issues; key; klebsiella; knowledge; known; kp342; kpc; laboratories; laboratory; lack; lactamases; large; lead; length; levels; life; like; likely; limited; literature; liver; local; location; long; longer; loss; low; lower; lps; macrolide; main; major; majority; malaria; male; management; manifestations; mass; mbl; mdr; mds; mean; measures; mechanisms; median; medical; medicine; medium; meningitis; meningofinder; meropenem; methicillin; methods; mice; microbiology; microscopy; mics; mlst; model; molecular; monitoring; months; morbidity; mortality; mothers; mrsa; mrsa isolates; mssa; multi; multidrug; multiple; mutants; mutations; mxf; n =; national; need; negative; netherlands; network; neutrophils; new; non; north; nosocomial; novel; nucleic; number; objectives; observational; observed; old; onset; opt-80; optimal; options; oral; order; organisms; origin; outbreak; outcome; overall; paediatric; parasites; particular; past; pathogenesis; pathogens; patients; patterns; pcr; penicillin; people; performance; period; persistence; persons; pfge; phage; phenotype; physicians; pigs; pip; pji; plasma; plasmid; pneumococcal; pneumoniae; point; poor; population; pork; positive; positive isolates; positive results; possible; post; potential; practice; pregnancy; preliminary; presence; present; presentation; prevalence; prevention; primary; primers; prior; probes; problem; process; producers; producing; production; products; profile; prolonged; promising; promoter; prophylaxis; proportion; prospective; protein; protocol; pseudomonas; pts; public; pulmonary; pvl; quality; questions; rama; ramr; randomised; range; rapid; rare; rate; reaction; readiness; real; realtime; recent; receptors; recipients; recognition; recombinant; recurrent; reduced; reference; regions; related; relative; relevant; replication; reported; reporting; reports; required; research; resistance; resistance genes; resistant isolates; respiratory; response; responsible; restriction; resulted; results; review; ribotype; rifampicin; risk; rna; role; routine; rrna; safety; salmonella; samples; sccmec; schools; screening; sdd; second; secondary; selection; selective; sensitive; sensitivity; sepsis; septic; sequence; sequencing; sera; serotype; serum; service; sesc; setting; severe; severity; shock; short; significant; similar; single; site; situation; skin; slime; small; soft; source; south; species; specific; specificity; specimens; spectrum; spp; spread; staff; staining; standard; staphylococcus; statistical; stay; stool; strains; strategies; strategy; streptococcus; strong; structure; studies; study; subjects; subsequent; successful; support; surgery; surgical; surveillance; survey; survival; susceptibility; susceptible; swab; symptoms; syndrome; system; systemic; table; target; tazo; techniques; technologies; technology; term; testing; tests; tetracycline; therapeutic; therapy; time; time pcr; tissue; tlr2; tools; total; toxin; tract; transcription; transmission; treatment; trends; trials; triazoles; trimethoprim; tuberculosis; type; typing; underlying; understanding; unique; unknown; urine; usa; use; vaccination; vaccine; value; vancomycin; vap; variation; viral; virulence; virus; viruses; visa; vitro; vx-166; vzv; ward; water; weeks; western; wide; women; work; world; worldwide; years
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10. cord-010980-sizuef1v
    • author: None
    • title: ECTES Abstracts 2020
    • date: 2020-05-11
    • words: 132805
    • flesch: 50
    • summary: Investigation of coagulopathies and its relevance with mortality and transfusion rates using thromboelastography in trauma patients Introduction: Inter-hospital variation in surgical intensity for trauma admissions: a multicenter cohort study L. Moore 1 , M. P. Patton 2 , I. Farhat 2 , P. A. Tardif 2 , C. Gonthier 3 , A. Belcaid 3 , F. Lauzier 2 , A. Turgeon 2 , J. Clément 2 1 Université Laval, Social and preventive medicine, québec, Canada, 2 CHU de Québec-Université-Laval, Québec, Canada, 3 Introduction: Guidelines for trauma patients are increasingly moving away from surgical management towards less invasive procedures but there is a knowledge gap on how these recommendations are influencing practice.
    • keywords: 0.001; 1,2; 1st; abc; abdomen; abdominal; abdominal injuries; abdominal trauma; abscess; absence; access; accident; accident patients; account; accuracy; accurate; acetabular; acs; activation; active; activities; activity; acute; acute patients; acute trauma; additional; adequate; adjusted; administration; admission; adult patients; adult trauma; adults; advanced; adverse; affected; age; age group; aged; agreement; aim; aims; airway; ais; alcohol; algorithm; alignment; allograft; alternative; ambulance; amputation; analysed; analysis; anastomosis; anatomical; angioembolization; angiography; animals; ankle; anterior; antibiotic; anticoagulation; aorta; appendectomy; appendicitis; appendicular; application; approach; appropriate; ards; area; arrest; arrival; arterial; artery; arthroplasty; articles; articular; assessment; associated; associated injuries; association; atls; atypical; audit; august; authors; availability; available; average; awareness; background; balloon; baseline; bearing; benefit; best; better; bicycle; bilateral; bleeding; blood; blunt trauma; bmi; body; bone; bone injury; bony; bowel; brain; brain injury; brain trauma; bsi; burden; burn patients; burns; calculated; cap; capacity; cardiac; care surgery; case history; cases; cast; casualties; casualty; catheter; cause; cavity; cell; center study; centers; central; centre; cerebral; cervical; challenges; challenging; changes; characteristics; chest; chest injuries; chest trauma; children; cholecystectomy; chronic; civilian; classification; clavicle; clear; clinical; clinical findings; clinical outcomes; clinical results; closed; closure; clot; coagulation; coagulopathy; cohort; cohort study; collected; collection; colon; colonic; coma; combat; combination; combined; comments; comminuted; common; communication; comorbidities; comparable; compare; comparison; compartment; complete; complex; complicated; complications; compression; concentration; concept; conclusions; concomitant; condition; conflicts; consecutive patients; consequences; conservative; conservative treatment; consolidation; constant; contact; content; contrast; control; controversial; conventional; correct; correlated; correlation; corridor; cortex; costs; countries; course; criteria; critical; ct scan; current; daily; damage; data; database; date; days; days mortality; dead; death; debridement; december; decision; decrease; dedicated; deep; defect; deficit; definitive; deformity; degree; delayed; demographic; department; descriptive; design; determined; developed; development; device; diagnosis; diameter; diaphragmatic; differences; different; difficult; direct; disability; disaster; discharge; discussion; disease; dislocation; displacement; disruption; distal; distance; distribution; diverticulitis; dorsal; dose; drainage; dstc; duration; dutch; early; easy; educational; effective; effectiveness; effects; efficacy; elderly patients; elderly trauma; elective; eligible patients; embolization; emergencies; emergency; emergency department; emergency surgery; emergency surgical; emergent; endoscopic; endovascular; energy; energy trauma; enhanced; epp; esophageal; essential; established; european; evaluation; events; evidence; examination; excellent; exercise; existing; experience; exploration; exposure; extension; extensive; extent; external; extremities; extremity; extremity trauma; facilities; factors; failure; falls; fascial; fast; fatal; feasible; female; femoral; femur; fever; fibrinogen; fibrinolysis; field; fig; figure; final; financial; findings; finger; fire; fistula; fixation; fixator; flexion; flow; fluid; fluoroscopy; focus; follow; following; foot; forearm; foreign; fractures; fragment; frailty; free; french; frequent; functional; functional results; gaba; gap; gastric; gcs; gender; general; general surgery; geriatric; germany; glasgow; good; gos; grade; graft; greater; group; guidelines; gunshot; half; hand; hap; head; head injury; healing; health; healthcare; heart; height; help; hematoma; hemodynamic; hemoglobin; hemorrhage; hemostasis; hems; hepatic; hernia; high; high mortality; higher; highest; hip; history; home; hospital; hospital mortality; hospital stay; hospital trauma; hospitalization; hours; humeral; hyperbilirubinemia; hypotension; icu; iii; iliac; images; imaging; immediate; imn; impact; implant; implementation; important; improved; improvement; incidence; incidents; inclusion; increased; independent; index; indications; induced; infection; inferior; inflammatory; influence; information; initial; injured; injuries; injury; injury mechanism; injury severity; insertion; inside; institution; insufficient; intensity; intensive; interest; internal; international; intertrochanteric; intervention; intestinal; intraabdominal; intramedullary; intraoperative; intraperitoneal; intravenous; introduction; intubation; invasive; investigation; involved; iqr; ischemia; isolated; israel; iss; issues; january; japan; joint; july; kappa; key; kidney; kingdom; knee; knife; knowledge; known; laboratory; laceration; lack; laparoscopic; laparotomies; laparotomy; large; largest; lateral; lead; leading; left; leg; length; lesions; level; life; ligament; likely; limb; limited; linear; literature; little; liver; local; locking; logistic; london; long; longer; loop; loss; lower; lumbar; madrid; main; major trauma; majority; making; malalignment; male; male patients; malleolus; management; mandatory; march; mass; massive; material; mci; mcs; mean; mean age; measurements; measures; mechanical; mechanism; median; medical; medicine; membrane; meniscus; mesenteric; mesh; mess; methods; middle; mild; military; minimal; minimum; minor; missed; mmhg; mobility; model; monitoring; months; morbidity; mortality; mortality rate; motion; motor; mri; mtbi; mtp; multidisciplinary; multiple; multitrauma patients; multivariate; muscle; n =; nail; nailing; national; national trauma; navigation; necessary; neck; necrosis; need; negative; nerve; netherlands; neurological; neurovascular; new; niss; nom; non; nonunion; normal; norway; norwegian; novel; npwt; number; objective; observational; observational study; observed; obstruction; occlusion; october; okayama; old; onset; open; operated; operating; operation; operative; opioid; optimal; option; order; organ; orif; orthopaedic; oslo; osteochondral; osteosynthesis; osteotomy; outcomes; outpatient; overall; overall mortality; oxygen; p =; pab; packing; paediatric patients; pain; palsy; pancreatic; pancreatic trauma; parameters; partial; participants; past; patella; patient age; patient group; patient outcomes; patients c; patients introduction; patients victims; pattern; pediatric patients; pediatric trauma; pelvic; pelvic fractures; pelvic injury; pelvic trauma; penetrating; people; percutaneous; perforation; performance; perfusion; period; peritoneal; peritonitis; personnel; pfna; phase; physical; pics patients; planned; plasma; plate; pleural; pneumonia; pneumothorax; points; polytrauma patients; poor; popliteal; population; position; positive; possible; posterior; postoperative; posttraumatic; potential; practice; prbc; predictive; predictors; prehospital; preoperative; presence; present; present study; presentation; pressure; prevalence; prevention; previous; primary; prior; problem; procedure; process; products; profile; prognosis; program; progressions; prolonged; proportion; propranolol; prospective; protocol; proximal; public; pulmonary; purpose; quality; questionnaires; radial; radiographs; radiological; radiology; radius; randomized; range; rapid; rare; rate; rats; ray; rays; reasons; reboa; recent; recommendations; reconstruction; records; recovery; rectal; recurrence; reduced; reduction; references; region; regional; regression; rehabilitation; related; relationship; relative; relevant; reliability; removal; renal; repair; reported; reports; research; resection; resources; respiratory; response; results; resuscitation; retrospective; retrospective study; return; review; revised; revision; rib; rib fractures; right; risk; road; role; room; rotational; routine; rupture; rural; sae; safe; safety; samples; satisfaction; saw; sbp; scale; scan; scenarios; scene; score; scoring; screw; secondary; segment; self; sensitivity; sepsis; september; septic; series; service; setting; severe; severe trauma; severity; sex; shaft; shock; short; shorter; shoulder; showing; shows; sided; sigmoid; significant; signs; similar; simple; simulation; single; site; size; skills; skin; small; society; soft; south; space; specialist; specific; specificity; spinal; spine; spleen; splenectomy; splenic; splenic injury; splenic trauma; spontaneous; stability; stabilization; stable patients; staff; standard; standardized; state; statistical; status; stay; step; stomach; strategies; strategy; stress; strong; structure; students; studies; study; study introduction; study period; study population; subgroup; subsequent; successful; superior; support; supracondylar; surface; surgeons; surgeries; surgery; surgery patients; surgical; surgical management; surgical patients; surgical trauma; surgical treatment; survey; survival; survivors; suspicion; suture; symptomatic; symptoms; syndrome; system; systematic; systolic; tae; tbi; tbi patients; teaching; teams; technique; tenderness; tendon; term; tertiary; test; tha; therapeutic; therapy; thickness; thoracic; thoracic trauma; thoracotomy; tibial; time; tissue; tissue injury; tomography; tool; total; tourniquets; tpa; tracheostomy; traction; traffic; training; transfer; transfusion; transport; trauma care; trauma center; trauma data; trauma emergency; trauma icu; trauma introduction; trauma management; trauma mechanism; trauma mortality; trauma outcome; trauma patients; trauma population; trauma registry; trauma resuscitation; trauma surgery; trauma system; trauma team; trauma unit; traumatic; traumatology; treatment; treatment results; trend; triage; trochanteric; tube; type; ulna; ultrasound; uncommon; understanding; underwent; uneventful; union; unit; united; university; university hospital; unstable; upper; urgent; use; useful; value; variables; variation; vascular; vascular injury; vehicle; vein; venous; vertebral; victims; virtual; vital; volume; volvulus; vte; wall; war; weeks; wires; women; work; working; worldwide; wound; wrist; years; years old; young; younger patients; zone
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11. cord-011282-hgzneooy
    • author: David, Yadin
    • title: Evidence-based impact by clinical engineers on global patients outcomes
    • date: 2019-07-02
    • words: 5423
    • flesch: 32
    • summary: National health technology management system for public hospitals in Turkey improve the performance and cost efficiency of the technology that patient management is dependent upon. Therefore, it is essential that health technology (HT) be strategically guided and optimally managed [4] .
    • keywords: access; analysis; better; biomedical; case; categories; category; clinical; clinical engineering; contributions; cost; countries; critical; data; delivery; deployment; development; devices; diagnostic; disease; engineering; engineers; equipment; evidence; expertise; global; group; health; health services; health technology; healthcare; hospital; human; ifmbe; impact; innovation; integration; international; life; literature; maintenance; management; medical; medical devices; new; optimal; outcomes; overall; patient; performance; professionals; programs; project; qualified; quality; region; related; resources; results; review; safety; services; studies; study; submission; success; support; survey; systems; tables; technological; technology; technology management; volume; world; world health; years
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12. cord-014337-nnuvrb6o
    • author: Byrne, S.
    • title: Scientific rigour
    • date: 2020-11-13
    • words: 1530
    • flesch: 50
    • summary: Despite facing changes in a teaching format, especially in clinical training, our approaches, including the use of online portals and modules, maintained and enhanced PGRs' hands-on and didactic experiences. Br Dent J DOI: 10.1038/s41415-020-2362-4 sha: doc_id: 14337 cord_uid: nnuvrb6o nan for dental education and training, while measures are in place to control the spread of COVID-19.
    • keywords: approaches; authors; clinical; colleagues; cov-2; curricula; data; dental; didactic; education; feedback; hygiene; letter; oral; patients; periodontal; pgrs; product; research; residents; sars; sessions; sir; surgical; teaching; techniques; time; training; use
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13. cord-014687-0am4l5ms
    • author: None
    • title: SPR 2012
    • date: 2012-03-29
    • words: 98702
    • flesch: 39
    • summary: Image Gently has succeeded not only in raising awareness of the great diagnostic benefits we can offer to pediatric patients but also directs us to acknowledge the downside of overzealous diagnostic efforts where excessive radiation becomes a risk. Methods & Materials: Pediatric patients who had high temporal resolution cine Steady State Free Precession sequence (50 frames acquired across a single cardiac cycle) performed as part of a MRI/MRA of the heart from 2005-2011 were included.
    • keywords: abdomen; abdominal; abdominal ct; ability; abnormalities; abnormality; abscess; absence; absent; abuse; abusive; access; accidental; accuracy; accurate; acquisition; acr; activity; acute; adc; additional; additional imaging; adjacent; adjusted; administration; adolescent; adult; advanced; advanced imaging; advantages; affected; age; agent; agreement; aid; aim; airway; amenorrhea; american; analysis; anatomic; anatomy; anesthesia; angiography; ankle; anomalies; anomaly; anterior; aortic; appearance; appendicitis; appendix; application; approach; appropriate; approval; areas; arfi; arnold; arterial; arteries; arteriosus; artery; arthritis; artifacts; ascites; asir; assessment; associated; association; asymptomatic; atelectasis; atresia; atrophy; attention; auditory; authors; available; average; award; awareness; axial; baseline; basis; benign; best; better; bilateral; biliary; biopsy; birth; blinded; blood; board; bodies; body; bold; bone; bone imaging; bony; boston; bowel; boys; brain; brain mri; brief; brochure; c11; caffey; callosum; campaign; canal; cardiac; cardiovascular; care; cartilage; case report; cases; catheter; cause; cell; center; central; cerebellum; cerebral; certain; cervical; cevus; chair; challenging; changes; channel; characteristics; characterization; characterized; chest; chest ct; childhood; children; chronic; cincinnati; classic; classification; clinical; clinical findings; clinical imaging; clinical presentation; cmet; cnr; cns; coefficient; cohort; coil; collected; college; color; combination; combined; committee; common; common imaging; community; comparison; complete; complex; complicated; complications; component; compression; conclusions; conditions; confidence; congenital; connectivity; consecutive; consider; consistent; contacts; content; contrast; contrast imaging; control; conventional; conventional mri; cord; coronal; coronary; corpus; correlate; correlation; corresponding; cortex; cortical; cost; course; cranial; craniosynostosis; criteria; critical; cross; ct dose; ct findings; ct image; ct imaging; ct radiation; ct scans; cta; ctdivol; current; cystic; cysts; data; database; date; david; days; decision; decreased; dedicated; defects; deficiency; definition; deformity; degree; delayed; delivery; demonstrating; density; department; dependent; depth; detection; determined; development; device; diagnosis; diagnostic imaging; diameter; differences; different; different imaging; differential; differential diagnosis; difficult; diffuse; diffusion; dilatation; dilated; disability; disclosure; discussion; disease; disease patients; disorders; distal; distribution; division; dmsa; dose; drug; dti; ductus; duplex; duration; dwi; dynamic; dysplasia; early; echo; ectopic; edema; educational; effective; effects; efforts; effusion; elbow; electronic; embolization; embryology; emergency; emphasis; enhancement; enlarged; entities; entity; epilepsy; epiphyseal; epiphysis; essay; essential; established; estimates; etiologies; etiology; evaluation; events; evidence; evident; examination; examples; exams; excellent; exhibit; expected; experience; exposure; extent; extremity; factors; faculty; failure; family; fast; fat; fatty; fda; fdg; fellowship; female; femoral; fetal; fetal mri; fibrosis; field; film; final; flow; fluid; fluoroscopy; fmri; focal; focused; follow; following; followup; food; forms; fossa; fractures; free; frequency; functional; future; gadolinium; gastrointestinal; gender; general; genetic; george; gestation; girls; goal; gold; good; grade; gradient; greater; greatest; group; growth; guide; guidelines; harvey; head; healthcare; healthy; hearing; heart; heart disease; helical; help; helpful; hemophilic; hemorrhage; hepatic; hernia; hie; high; higher; highest; hip; history; hospital; hydration; hydronephrosis; hypertension; hypoplasia; hypoxic; identification; identifying; illustrated; image quality; images; imaging; imaging appearance; imaging approach; imaging centers; imaging characteristics; imaging database; imaging evaluation; imaging features; imaging findings; imaging manifestations; imaging modalities; imaging patterns; imaging studies; imaging techniques; immediate; impact; important; improved; improvement; incidence; increase; index; indications; individual; infancy; infants; infection; infiltration; inflammation; inflammatory; information; inherent; initial; injuries; injury; institute; institution; intended; intensity; interactive; interest; internal; interpretation; interstitial; interventional; intestinal; intracranial; intravenous; invasive; investigational; involved; involvement; ionizing; irb; iron; ischemic; isolated; issues; john; joint; kelly; key; key imaging; kidney; knee; knowledge; known; kvp; lack; language; large; lead; leadership; left; length; lesions; level; life; ligamentous; likely; limited; linear; literature; little; liver; localization; location; long; loss; low; lower; lung; lymphatic; lymphoma; magnetic; main; major; majority; making; male; malformations; malignant; malrotation; management; manifestations; maps; marilyn; marrow; mass; masses; materials; matter; maximum; mdct; mean; measurements; measures; meconium; median; mediastinal; medical; medical imaging; medicine; meeting; members; methods; mgy; michael; michigan; mild; minimal; mm2; modality; model; moderate; modules; monitoring; months; morbidity; morphology; motion; mr images; mr imaging; mra; mrcp; mre; mri; mri findings; mri studies; mri system; mrs; multimodality imaging; multiple; muscle; musculoskeletal; mutations; myocardial; narrowing; national; necessary; neck; need; needle; negative; neiman; neonatal; neonates; neoplasms; neoplastic; nerve; nervous; neuroblastoma; neuroimaging; neurologic; new; newborn; nf1; nf1 patients; nicu; noise; non; normal; number; numerous; objective; observed; obstruction; old; operative; operator; optic; optimal; organ; osseous; osteochondral; osteoid; osteomyelitis; osteonecrosis; outcome; outside; overall; p<0.0001; pain; pancreatic; paper; parallel imaging; parameters; parenchymal; parents; particular; past; patent; pathological; pathologies; pathology; pathophysiology; patient age; patients; patterns; pediatric; pediatric abdominal; pediatric age; pediatric brain; pediatric ct; pediatric disease; pediatric elbow; pediatric head; pediatric hospital; pediatric imaging; pediatric liver; pediatric musculoskeletal; pediatric patients; pediatric population; pediatric radiology; pediatric spine; pediatric stroke; pelvis; percentage; percutaneous; performance; period; peroxisomal; pertinent; pet; phantom; pharmaceutical; phase; phd; philadelphia; philips; physical; pictorial; pitfalls; pituitary; placement; planning; plays; points; pool; poor; population; portal; portion; position; positive; possible; post; posterior; postnatal; postnatal imaging; potential; practice; precision; predictive; preferred; premature; prenatal; presence; present; presentation; president; pressure; primary; prior; probe; procedure; process; processes; processing; prognosis; program; progressive; prospective; protection; protocol; proximal; pulmonary; purpose; pvt; quality; quantitative; radiation; radiation dose; radiographs; radiologic; radiologists; range; rapid; rare; rates; ray; reader; recent; recognition; reconstruction; records; recurrent; reduction; reference; reflux; regions; regression; related; relationship; relative; relevant; relevant imaging; reliable; renal; reports; representative; research; resection; residents; resolution; resonance imaging; respect; respiratory; respondents; response; restricted; results; retroperitoneal; retrospective; retrospective review; review; rhabdomyosarcoma; rib; richard; right; risk; robust; role; routine; royal; rupture; safety; sarcoma; scale; scan; scanner; scientific; scores; screening; scrotum; sdh; secondary; sectional; sectional imaging; sedation; sensitive; sensitivity; sequences; sequestration; series; setting; severe; severity; short; shoulder; shunt; sick; signal; significant; signs; similar; single; sinusitis; site; situs; size; skeletal; skin; skull; slice; small; smaller; snr; society; soft; software; solid; sonographic; space; spatial; specific; specific imaging; specificity; specimens; spectrum; spinal; spine; spleen; spr; src; ssde; standard; standardized; state; statistical; status; stenosis; stents; step; strategies; stroke; strong; structures; stuart; studies; study; subjects; subsequent; subtle; successful; superior; support; surgery; surgical; survey; survivors; suspicion; swelling; swi; symptoms; syndrome; system; systematic; table; target; teaching; team; technical; technique; technologists; temporal; term; tertiary; tesla; test; testicular; tflv; therapeutic; therapy; thickening; thoracic; thought; thrombosis; time; tissue; tomography; tool; torsion; total; tract; training; transplant; trauma; traumatic; treatment; true; tube; tuberculosis; tumor; type; typical; ultrasonography; ultrasound; uncommon; underlying; understanding; underwent; unique; university; upper; uptake; use; useful; utility; value; variability; variable; variants; variation; varied; variety; vascular; vcug; vein; venous; ventricle; ventricular; vertebral; vessels; visualization; vitamin; volume; voxel; wall; water; weeks; weighted; white; wide; width; work; workup; years; young; yrs
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14. cord-015334-8p124rwp
    • author: None
    • title: ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts
    • date: 2008-06-11
    • words: 51170
    • flesch: 47
    • summary: The main off-label indications were prevention of hemorrhagic risk of antiplatelet agent (23%), hemoglobin decrease(16%), anticoagulant co-prescription(13%), steroids co-prescription(6%). A rinse volume of 10 ml improved significantly the transit of Mopral Ò , Ogast Ò and Ogastoro Ò (+4.8%,
    • keywords: acceptance; accepted; access; account; acid; active; activities; activity; acute; adapted; addition; adherence; adjustment; administration; admission; adrs; adults; adverse; age; agent; agreement; aha; aim; amikacin; analysis; anemia; antibiotic; anticancer; antidepressants; application; approach; appropriate; approval; area; assessment; associated; association; asthma; authorities; available; average; awareness; background; basis; beds; behaviour; benefit; beta; better; biological; blood; body; cancer; cardiovascular; care; care unit; cases; center; change; characteristics; chemotherapy; children; cholesterol; chronic; clinical; clinical pharmacy; combination; common; communication; community; community pharmacy; compassionate; complete; compliance; complications; computerized; concentration; concern; concerned; conclusions; conditions; consensus; consultation; contact; control; conversion; correct; correlation; cost; cotrimoxazole; cough; counselling; count; course; creatinine; criteria; current; cvd; daily; data; database; date; days; decrease; demographic; department; depression; design; development; diabetes; diagnosis; differences; different; discharge; discussion; disease; dispensation; dispensing; dosage; dose; drp; drps; drug; drug information; drug treatment; duration; early; economic; effective; effectiveness; effects; efficacy; elderly; emergency; episodes; errors; estonia; evaluation; events; evidence; examination; experience; face; factors; failure; female; findings; folic; follow; following; forms; formulation; france; french; frequency; frequent; function; general; genotypes; glucose; good; grade; group; guidelines; half; health; health care; heart; help; high; higher; hiv; home; hospital; hospital pharmacy; hours; human; ics; identification; impact; implementation; important; improved; improvement; incidence; inclusion; increase; indications; individual; infections; inflammatory; infliximab; information; infusion; inhibitors; inr; insufficient; intake; intensive; interactions; interventions; interview; intravenous; issues; items; ivermectin; ivig; january; keywords; knowledge; label; laboratory; lack; large; leaflet; learning; length; level; life; literature; lmol; local; long; lower; main; main outcome; majority; male; management; mean; measures; median; medical; medication; medicine; method; milk; minor; mitomycin; moderate; modes; monitoring; months; multidisciplinary; multiple; n =; nasogastric; national; necessary; need; negative; nerh; new; non; number; nurses; nutrition; objective; observational; observed; old; oncology; optimal; oral; order; otc; otitis; outcome; outcome measures; outpatient; overall; paediatric; paediatric patients; pain; parameters; parenteral; paris; participants; patient care; patients; percentage; performance; period; pharmaceutical; pharmaceutical care; pharmacists; pharmacovigilance; pharmacy; pharmacy department; phase; physical; physicians; platelet; players; pneumonia; poor; population; positive; possible; post; potential; practice; preferred; pregnancy; preparation; prepared; prescribed; prescribing; prescriptions; present; pressure; prevalence; prevention; previous; primary; prior; problems; procedures; process; products; professionals; profile; program; promotion; prophylaxis; propofol; prospective; protocol; public; pulmonary; purpose; quality; questionnaire; questions; range; rate; reaction; reason; recommendations; records; reduced; reduction; regimen; related; relevance; relevant; renal; reperfusion; reported; reports; research; respect; respiratory; response; results; retrospective; retrospective study; review; rhuepo; risk; rituximab; role; route; rtx; safety; sample; sampling; satisfaction; satisfied; scale; scheme; score; second; secondary; selected; self; serum; service; setting; severe; severity; significant; similar; single; skills; skin; sodium; software; solution; specific; ssri; stability; staff; standardized; starting; stay; students; studies; study; subjects; suggested; support; surface; surgery; surgical; survey; survival; symptoms; syndrome; system; tablets; target; teaching; team; technique; terms; test; therapeutic; therapies; therapy; time; tool; topical; total; toxicity; training; treatment; trials; tubes; tuh; type; units; university; university hospital; usage; use; useful; users; value; vancomycin; visit; volume; voriconazole; ward; water; way; weeks; weight; women; working; years
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15. cord-017331-ru7mvfc0
    • author: Samanta, Indranil
    • title: Infectious Diseases
    • date: 2017-02-25
    • words: 37743
    • flesch: 42
    • summary: Among different species under the genus Mycoplasma, M. gallisepticum, M. iowae, and M. sturni are associated with pet bird infection. Among the members of family Reoviridae, Orbivirus mostly causes pet bird infection.
    • keywords: abv; acid; acts; acute; adult; aestiva; affected; affected birds; african; agar; agent; air; aiv; amazon; america; amino; analysis; animals; anorexia; antibiotics; antibodies; antibody; antigen; aspergillosis; aspergillus; assay; associated; asymptomatic; attachment; australia; available; avian; aviaries; avium; bacteria; beak; bfdv; biology; birds; blood; blue; bodies; body; bornavirus; borrelia; bovine; brain; brazil; breeding; budgerigars; buffered; burgdorferi; c. psittaci; cage; campylobacter; canaries; canary; candida; capsule; captive; carduelis; carrier; cases; cause; cavity; cells; cellular; central; chicken; china; chlamydia; chlamydiosis; chlamydophila; chronic; clade; clinical; clinical infection; clinical samples; clinical signs; clinical specimens; cloacal; cockatiels; cockatoos; coli; collected; collection; colonization; coloured; columba; columbiformes; common; conjunctivitis; contact; contaminated; contrast; control; countries; crop; cryptococcosis; cryptococcus; cryptosporidiosis; cryptosporidium; culex; cycle; days; dead; death; depression; detection; development; diagnosis; diameter; diarrhoea; different; direct; disease; disease virus; disinfectants; distinct; dna; domestic; drinking; drug; duck; e.g.; ebs; effective; eggs; electron; elisa; embryo; encephalitis; enlarged; enterica; enterocytes; environment; enzyme; epithelial; erithacus; escherichia; esophagus; ethambutol; etiological; eurasian; europe; european; evidence; examination; excreated; experimentally; exposure; eye; factors; faecal; faeces; family; fast; fatal; feather; feed; feeding; fever; fig; finches; findings; fledgling; food; form; formalin; formation; free; fresh; fronted; fumigatus; fungal; fungi; fusion; gallisepticum; gastrointestinal; gattii; geese; genavense; gene; general; genome; genotypes; genus; giardia; giardiasis; giemsa; gondii; gram; granuloma; gray; green; grey; gross; group; growth; h5n1; head; healthy; heart; help; high; history; hollandicus; host; house; hpai; human; identification; immune; immunity; inclusion; incubation; infected; infected birds; infection; infiltration; inflammation; influenza; ingestion; inhalation; inoculated; intermediate; interval; intestine; isolated; isolation; ixodes; japan; jejuni; kidney; laboratory; large; lesions; lethargy; life; like; lineage; live birds; liver; lories; loss; lovebirds; lung; lyme; m. avium; macaws; macrophages; maintenance; major; media; medium; melopsittacus; membrane; mice; microscopy; migratory; migratory birds; molecular; months; mortality; mortem; mosquitoes; mucosa; multocida; muscle; mycobacteriosis; mycobacterium; mycoplasma; nasal; natural; nature; ndv; necrosis; necrotic; negative; neoformans; nervous; new; newcastle; nile; non; numbers; nymphicus; occurrence; oocysts; oral; order; organisms; organs; outbreak; pancreas; parakeets; parasite; parrots; passeriformes; passerine birds; passerines; pasteurella; pathogenic; patients; pcr; pdd; period; persistent; pet birds; phase; pigeons; place; polymerase; population; positive; possibility; possible; post; potential; poultry; preferred; presence; present; prevalence; primary; process; production; prolonged; protein; protozoa; proventriculus; psittaci infection; psittaciformes; psittacine birds; psittacines; psittacosis; raptors; real; red; region; replication; reservoir; resistant; respiratory; response; review; ring; risk; rodents; role; route; ruffled; s.l; sacs; saline; salmonella; salmonellosis; samples; sequence; serinus; serological; serum; shaped; signs; single; skin; slow; small; smears; source; south; sparrows; species; specific; specimens; spleen; sporozoites; spp; spread; ssp; stained; staining; starling; states; strains; structural; studies; study; subsp; successful; sudden; surface; survival; susceptible; susceptible birds; swabs; swollen; symptoms; syndrome; system; t3ss; table; temperature; tests; therapy; thickened; ticks; time; tissue; toxoplasmosis; trachea; tract; transmission; transport; treatment; trophozoites; tuberculosis; turdus; type; typhimurium; typical; undulatus; united; usa; use; usutu; usuv; usuv infection; vaccination; vaccine; vector; velogenic; viral; virulence; virus; virus infection; viruses; wall; water; way; weeks; weight; west; white; wild birds; winged; wnv; wnv infection; years; yeast; yellow; yersinia; young; young birds; zoonotic
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16. cord-018335-4l7scdqk
    • author: Kiechle, Frederick L.
    • title: Utilization Management in a Large Community Hospital
    • date: 2016-12-01
    • words: 11072
    • flesch: 32
    • summary: Structure and impact in a large academic medical center Utilization management in a large urban academic medical center: a 10-year experience An analysis of reference laboratory (send out) testing: an 8-year experience in a large academic medical center Utilization management in toxicology An administrative intervention to improve utilization of laboratory tests within a university hospital Longitudinal trends in laboratory test utilization at a large tertiary care university hospital in Sweden Promoting improved utilization of laboratory testing through changes in an electronic medical record: experience at an academic medical center Effect of a controlled feedback intervention on laboratory test ordering by community physicians Duplicate laboratory test reduction using a clinical decision support tool Clinical laboratory tests not performed in a central hospital laboratory Establishing benchmarks and metrics for disruptive technologies, inappropriate and obsolete tests in the clinical laboratory Managing the demand for laboratory testing: options and opportunities Managing the generation mix: from collision to collaboratoryoration Utilization management in the changing health-care environment The impact of hospital acquisition of physician practices on referral patterns. Assessment of laboratory test utilization usually relies on data compiled after a utilization review or analysis of the necessity, appropriateness, and effi ciency of laboratory tests on a concurrent and/or retrospective basis.
    • keywords: ability; academic; analysis; antibiotic; antigen; antimicrobial; approach; assay; aureus; automation; available; average; bacteria; beaumont; benefi; blood; blood culture; candida; care; cation; cell; center; central; chemistry; clinical; clinical laboratory; clinical microbiology; committee; community; community hospital; consolidation; cost; culture; data; decreased; defi; desorption; detection; diagnostics; direct; disease; dna; evaluation; filmarray; fish; gram; growth; health; healthcare; hospital; hospital laboratory; hospitalists; identifi; identifi cation; ight; impact; implementation; inc; increase; infections; infl; inpatient; internal; ionization; laboratories; laboratory; laboratory test; laboratory utilization; large; laser; length; maldi; management; market; mass; matrix; medical; medicine; methods; microbiology; microbiology laboratory; model; molecular; multiplex; need; negative; new; number; obsolete; order; outreach; overall; panel; pathogens; pathology; patient; pcr; performance; period; physician; pna; poct; point; positive; positive blood; potential; practices; procedures; profi; program; provider; quality; rapid; reagents; reference; reference laboratory; resistance; respiratory; results; review; routine; sample; savings; signifi; similar; species; specifi; spectrometry; staff; staphylococcus; stay; studies; study; susceptibility; system; table; technology; test; test utilization; testing; therapy; time; tof; total; turn; uenza; use; utilization; utilization management; viral; virus; volume; workfl
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17. cord-021453-vf8xbaug
    • author: Dysko, Robert C.
    • title: Biology and Diseases of Dogs
    • date: 2007-09-02
    • words: 42005
    • flesch: 46
    • summary: Preventing laboratory animals from contacting ticks is the primary means to avoid monocytic ehrlichiosis in research dogs. For this reason, medical treatment of heartworm disease is not usually attempted in research dogs.
    • keywords: abdominal; ability; abnormalities; acid; acral; acute; addition; adequate; administration; adult; affected; age; agents; aggressive; allergy; ammonia; anemia; angarano; animals; anorexia; antibiotic; antibody; appearance; areas; artery; ascarid; aspiration; associated; asymptomatic; atrophy; available; bacterial; beagles; behavior; benign; best; biomedical; biopsy; bitch; bite; blood; body; bone; bordetella; bph; breed; breeding; bronchiseptica; burn; canine; caninum; canis; cardiovascular; care; cases; cataracts; catheter; cats; cause; cavity; cells; changes; characteristic; chlorhexidine; choice; chronic; clean; clinical; clinical signs; closure; colony; common; complete; complications; condition; congenital; contact; contagious; contaminated; control; corneal; cough; culture; cycle; cysts; days; death; decrease; deficiency; definitive; demodicosis; dermatitis; development; diagnosis; diarrhea; diet; dietary; differential; differential diagnosis; difficult; direct; discharge; discomfort; discussion; disease; disorder; distemper; dogs; drug; dysplasia; early; edema; effective; effects; eggs; ehrlichia; ehrlichiosis; elbow; encephalopathy; endothelial; energy; enlarged; entire; environment; epithelial; epizootiology; essential; estrogen; estrus; et al; etiology; examination; excision; exercise; experimental; exposure; extensive; external; eye; facilities; facility; factors; failure; fat; fatty; fecal; feces; female; fenbendazole; ferguson; fever; fibers; fig; findings; flea; fluid; food; form; free; function; fungal; gastric; gastrointestinal; generalized; giardia; gland; good; grade; gram; granuloma; greene; gross; group; growth; hair; healing; health; heartworm; helicobacter; hemorrhages; hepatic; high; hip; histiocytomas; histopathologic; history; hormone; host; hours; human; hygromas; hyperplasia; hypothyroidism; identification; iii; illness; immune; immunologic; important; incidence; increase; indicative; individuals; indwelling; infected; infection; infective; infestations; inflammation; inflammatory; information; ingestion; initial; injury; intake; interdigital; intermediate; internal; intestinal; jejuni; joint; juvenile; kennel; laboratory; large; larvae; lens; leptospirosis; lesions; lethargy; levels; lewis; lice; lick; life; likely; liver; local; long; loss; low; lower; lung; lyme; lymphocytic; lymphoma; macewen; male; malignant; mammary; management; masses; mast; means; medicine; membranes; metabolism; metastasis; migration; mild; minimal; months; mucosa; mucous; muller; multiple; muscle; necessary; necrosis; need; negative; neoplasia; neurologic; new; nodes; normal; number; obesity; onset; oral; order; organism; pain; panciera; paralysis; parturition; parvovirus; pathogenesis; pathologic; period; peterson; phase; placement; platys; pneumonia; poor; population; positive; possibility; possible; potential; practice; presence; present; pressure; prevention; primary; problem; production; proper; prostatic; protein; protocols; pulmonary; puppies; pups; purpose; rabies; random; range; rapid; rate; red; removal; renal; reported; reproductive; requirements; research; research complications; research dogs; research setting; respiratory; response; result; right; risk; role; samples; secondary; section; self; semen; sensitivity; sepsis; serum; setting; severe; severity; significant; signs; similar; site; size; skin; small; soft; solution; source; source dogs; species; specific; spp; spread; stage; states; studies; study; subclinical; subcutaneous; superficial; supplementation; supportive; surface; surgery; surgical; swaim; swelling; syndrome; systemic; systems; techniques; temperature; term; tests; textbook; therapy; thrombocytopenia; tick; time; tissue; topical; total; tracheobronchitis; tract; transmissible; transmission; trauma; treatment; trevor; tsh; tumors; type; ulcers; united; unknown; use; uterine; vaccination; vaginal; variable; vascular; vasculitis; vector; venereal; veterinary; viral; virus; volume; vomiting; vulva; waldron; water; weeks; weight; whipworm; wide; worms; wound; years; young
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18. cord-021494-9glqvzfx
    • author: Funkhouser, William K.
    • title: Pathology: The Clinical Description of Human Disease
    • date: 2012-07-27
    • words: 2801
    • flesch: 31
    • summary: As the human genome is deciphered, and as the complex interactions of cellular biochemistry are refined, risk of disease in unaffected individuals will be calculable, disease diagnosis will be increasingly accurate and prognostic, and molecular subsets of morphologically defined disease entities will be used to guide customized therapy for individual patients. New molecular data for both neoplastic and non-neoplastic diseases will most likely benefit unaffected individuals by estimating disease risk, and will most likely benefit patients by defining the molecular subset for morphologically defined diagnostic entities, thus guiding individualized therapy.
    • keywords: acid; benefit; carcinoma; cell; clinical; criteria; current; data; diagnosis; differences; different; differential; disease; dna; emphysema; etiologies; etiology; example; features; findings; function; h&e; history; human; immunohistochemistry; likely; lineage; lung; malignant; molecular; morphologic; mutations; natural; neoplasms; new; normal; nucleic; outcome; particular; pathogenesis; pathologists; pathology; patients; prognosis; radiographic; response; risk; screening; single; small; specific; therapy; tissues; undifferentiated; uses
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19. cord-021555-rrverrsj
    • author: Delano, Margaret L.
    • title: Biology and Diseases of Ruminants: Sheep, Goats, and Cattle
    • date: 2007-09-02
    • words: 71795
    • flesch: 48
    • summary: In less severe outbreaks or individual animal disease, definitive diagnosis may never be made. Therefore, they should be housed in groups or at least within eyesight and hearing of other animals.
    • keywords: abdomen; abdominal; abnormalities; abomasal; aborted; abortion; abscesses; acid; acidosis; acute; addition; adequate; administration; adult; adult animals; affected; affected animals; age; agents; agricultural; amounts; anaerobic; anemia; animals; anorexia; antibiotics; antibodies; antibody; appropriate; arcanobacterium; areas; arthritis; artificial; associated; asymptomatic; ataxia; available; bacterial; base; beef; behavior; best; beta; birth; birthing; biting; black disease; bladder; bloat; blood; bloodstream; bluetongue; blv; body; bovine; bovis; brain; breeding; breeds; brown; brucella; brucellosis; bulls; bvdv; caev; calcium; calf; calves; campylobacter; caprine; cardiac; care; carriers; caseous; cases; cattle; causative; cause; cells; central; changes; characteristic; chlamydia; chronic; cleaning; clinical disease; clinical signs; clostridial; cold; coli; colostrum; commercial; common; comparable; complex; complications; concentrates; concurrent; condition; congenital; conjunctivitis; contact; contagious; contagious disease; contaminated; contamination; contrast; control; copper; cord; corneal; coronavirus; corynebacterium; course; cows; culture; culturing; cycle; dairy; dairy cattle; damage; dams; dark; days; dead; death; decrease; defects; deficiency; definitive; degeneration; dehydration; dependent; depressed; depression; dermatitis; detection; development; diagnosis; diarrhea; diet; dietary; differential; differential diagnosis; difficult; direct; discharges; disease; disease signs; disease virus; display; docking; doe; domestic; dose; dry; duration; early; ecthyma; edema; effective; effects; eggs; electrolyte; elevated; elisa; embryo; encephalitis; endemic; energy; enlargement; enterotoxemia; environment; enzootic; enzyme; epithelial; epizootiology; equipment; erosions; escherichia; essential; estrus; etiology; evidence; evident; ewes; example; excessive; experimental; exposure; external; facilities; facility; factors; failure; fall; family; farm; fatty; feces; fed; feed; feeding; feedstuffs; feet; female; fetal; fetuses; fever; findings; flies; flock; fluids; following; food; foot; form; formation; free; fusobacterium; gastrointestinal; generalized; genetic; gestation; gland; glucose; goats; good; gray; gross; group; growth; hair; handlers; handling; hay; head; health; heat; heifers; helpful; hemoglobinuria; hemolysis; hemolytic; hemorrhage; hepatic; herd; herpesvirus; high; holstein; hoof; host; housing; humans; hyperplasia; hyperthermia; hypocalcemia; identification; iii; illness; immune; immunity; important; inability; incidence; increase; incubation; individual; induced; industry; infected; infected animals; infection; inflammation; inflammatory; ingested; ingestion; initial; injuries; injury; insemination; intact; intake; interdigital; intermediate; internal; intestines; introduction; involved; isolated; isolation; johne; joints; kids; known; laboratory; lack; lambs; lameness; large; larvae; lead; length; leptospirosis; lesions; levels; lice; life; light; likely; limiting; listeria; liver; livestock; local; long; longer; loss; low; lungs; lymph; lymphadenopathy; lymphosarcoma; major; male; malignant; mammary; management; manifestations; mastitis; materials; maternal; mature; means; measures; medicine; membranes; mesenteric; metabolic; methods; migration; mild; milk; milking; models; modified; monitoring; months; morbidity; mortality; mouth; mouth disease; mucosa; mucous; multiple; muscle; muscular; mycobacterium; mycoplasma; nasal; natural; navel; necessary; neck; necrophorum; necropsy; necropsy findings; necrosis; necrotic; negative; nematodes; neonatal; neonates; neospora; nervous; new; newborn; nodes; non; nonmotile; normal; novyi; number; nursing; nutrition; ocular; older; older animals; oocysts; oral; organism; organs; outbreaks; oxytetracycline; pain; painful; palpation; paralysis; parasites; particular; parturition; passive; pasteurella; pasture; pathogenesis; pathogens; penicillin; pens; perfringens; period; persistent; photosensitization; placental; placentitis; pneumonia; poisoning; polyarthritis; poor; positive; possible; potential; practices; pregnancy; pregnant; presence; present; presentation; prevention; primary; problems; procedures; process; produce; production; products; prognosis; programs; progressive; prolapse; prolonged; proper; protein; pruritus; pseudotuberculosis; pulmonary; quality; rabies; range; rapid; rare; rates; reach; recent; recovery; rectal; red; regimens; related; removal; replacers; reportable; reproductive; requirements; research; research animals; reservoirs; resistant; respiratory; respiratory disease; response; rest; result; rhinotracheitis; risk; role; rotavirus; roughage; rumen; ruminal; ruminants; salmonella; sanitation; scrapie; screening; season; secondary; secretions; section; selenium; semen; sensitive; septicemia; serological; serology; serotypes; serum; severe; shedding; sheep; sherman; shipping; short; similar; single; size; skin; small; smaller; smears; smith; sodium; soil; solutions; sources; species; specific; spinal; sporadic; spore; spp; spread; spring; stage; standard; staphylococcus; states; stomach; stomatitis; strains; stress; stresses; subclinical; subcutaneous; subsequent; successful; sudden; sufficient; sulfate; supportive; surface; surgical; susceptible; swelling; swine; swollen; syndrome; system; systemic; tail; techniques; temperature; term; testing; tests; tetanus; therapy; ticks; time; tissues; toxemia; toxicity; toxin; toxoplasma; tract; transfer; transmission; trauma; treatment; trimester; tube; type; typical; udder; ulceration; ulcers; umbilicus; united; unthriftiness; urethral; urine; useful; uterine; uterus; vaccinated; vaccination; vaccine; vaginal; vectors; vesicles; vesicular; veterinary; viral; virus; vitamin; vulva; vulvovaginitis; wall; warm; warts; water; weak; weakness; weaning; weeks; weight; western; white; wild; winter; wool; worldwide; worms; wounds; years; yellow; young; young animals; younger; zinc; zoonotic
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20. cord-022034-o27mh4wz
    • author: OLANO, JUAN P.
    • title: Distinguishing Tropical Infectious Diseases from Bioterrorism
    • date: 2009-05-15
    • words: 10732
    • flesch: 36
    • summary: Shigella is a highly infectious organism that requires very low numbers (10 2 -10 3 organisms) to provoke clinical disease. They include presence of disease outbreaks of the same illness in noncontiguous areas, disease outbreaks with zoonotic impact, different attack rates in different environments (indoor versus outdoor), presence of large epidemics in small populations, increased number of unexplained deaths, unusually high severity of a disease for a particular pathogen, unusual clinical manifestations owing to route of transmission for a given pathogen, presence of a disease (vector-borne or not) in an area not endemic for that particular disease, multiple epidemics with different diseases in the same population, a case of a disease by an uncommon agent (smallpox, viral hemorrhagic fevers, inhalational anthrax), unusual strains of microorganisms when compared to conventional strains circulating in the same affected areas, and genetically homogenous organisms isolated from different locations.
    • keywords: acute; aerosol; agents; amplification; analysis; animal; anthracis; anthrax; antibodies; assays; attack; available; bacillus; bacteria; biological; bioterrorism; blood; botulinum; brucella; cases; certain; chapter; clinical; common; confirmation; contamination; cough; cutaneous; days; death; demonstration; detection; development; diagnosis; different; disease; dna; early; environmental; epidemic; epidemiological; equine; event; exposure; fever; food; form; gene; group; health; hemorrhagic; high; hours; human; identification; illness; immunohistochemical; incubation; infected; infectious; ingestion; inhalational; initial; intentional; isolation; laboratories; laboratory; large; lesions; lethal; level; management; manifestations; medical; microbiology; molecular; mortality; natural; new; nonspecific; order; organisms; outbreak; parvum; pathogenesis; pathology; patients; pcr; pestis; phase; plague; pneumonic; populations; possible; potential; presence; presentation; procedures; protein; public; pulmonary; range; rapid; rates; real; recognition; related; respiratory; responsible; ricin; rickettsiae; salmonella; samples; secondary; sensitivity; serological; severe; shigella; short; single; skin; smallpox; specialized; specimens; spores; spp; standard; states; strains; surveillance; symptoms; syndromes; syndromic; system; systemic; techniques; testing; tests; time; toxin; transmission; treatment; tularensis; type; typhus; united; use; viral; virus; viruses; warfare; weapons; work; world; yersinia
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21. cord-022203-t2f0vr1w
    • author: Dowers, Kristy L
    • title: The pyrexic cat
    • date: 2009-05-15
    • words: 8911
    • flesch: 50
    • summary: However, some cats do not develop detectable IgM titers, and in other cats, positive IgM titers can persist for months to years after infection. The condition, however, does not appear to be contagious to other cats.
    • keywords: abdominal; abscess; abscesses; acute; affected; anemia; animals; anorexia; antibody; available; bacterial; biochemistry; blood; bone; cases; cats; cause; cell; chain; chronic; classical; clinical; clinical signs; common; complete; count; culture; days; definitive; demonstration; depression; diagnosis; diarrhea; discharge; disease; dose; doxycycline; drugs; effective; effusive; evident; exposure; feline; felv; fever; fip; fiv; following; form; gastrointestinal; high; history; hours; humans; igm; immune; infected; infection; ingestion; initial; kittens; lesions; lethargy; leukocytes; likely; liver; loss; lymphadenopathy; main; mild; months; nasal; nodes; non; ocular; onset; oocysts; organism; page; panel; plague; polymerase; poor; positive; present; prognosis; reaction; reference; respiratory; response; result; serum; severe; signs; sneezing; suggestive; swelling; systemic; temperature; test; tetracycline; therapy; tissue; titers; toxoplasmosis; transmission; treatment; tumor; viral; vomiting; weeks; weight
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22. cord-022467-j2trahab
    • author: Loo, May
    • title: Select Populations: Children
    • date: 2009-05-15
    • words: 19091
    • flesch: 37
    • summary: Relationship between breast-feeding duration and acute respiratory infections in infants Cognitive training in ADHD children: less to it than meets the eye Hyperactive children treated with stimulants: is cognitive training a useful adjunct? Efficacy and safety of a fixed-combination homeopathic therapy for sinusitis Clinical assessment of acupuncture in asthma therapy: discussion paper Committee on Drugs: Guidelines for the ethical conduct of studies to evaluate drugs in pediatric populations Committee on Children with Disabilities: Counseling families who choose complementary and alternative medicine for their child with chronic illness or disability Measles-mumps-rubella immunisation, autism, and inflammatory bowel disease: update Evaluation of massage with essential oils on childhood atopic eczema Respiratory syncytial virus vaccines for otitis media The use of alternative therapies by children with asthma: a brief report Use of complementary and alternative medicine in the treatment of asthma Use of complementary treatment by those hospitalised with acute illness Some nontraditional (unconventional and/or innovative) psychosocial treatments for children and adolescents: critique and proposed screening principles Hypnotherapy in the treatment of bronchial asthma International study of asthma and allergies in childhood (ISAAC): rationale and methods Asthma mortality and hospitalization among children and young adults: United States Cranio-sacral therapy and the treatment of common childhood conditions A comparison of active and simulated chiropractic manipulation as adjunctive treatment for childhood asthma Hypnosis and self-hypnosis in the management of nocturnal enuresis: a comparative study with imipramine therapy Spirituality, religion, and pediatrics: intersecting worlds of healing Acupuncture and micro-massage in the treatment of idiopathic nocturnal enuresis Treatment of incontinent boys with non-obstructive disease Academic medicine and complementary medicine differ from each other in reasoning and evaluation but not in goals Alternative and controversial treatments for attention-deficit/hyperactivity disorder Parent acceptability and feasibility of ADHD interventions: assessment, correlates, and predictive validity Management of acute and chronic otitis media in pediatric practice Evaluation of rhesus rotavirus monovalent and tetravalent reassortant vaccines in U.S. children Traditional acupuncture increases the content of beta-endorphin in immune cells and influences mitogen induced proliferation A double-blind placebo-controlled study of desipramine in the treatment of ADD. I. General trends and demographic groups Relationship of infant feeding to recurrent wheezing at age 6 years Current treatment of allergic rhinitis and sinusitis 302 cases of enuresis treated with acupuncture Treatment of acne with ear acupuncture-a clinical observation of 80 cases 14 cases of child bronchial asthma treated by auricular plaster and meridian instrument Acupuncture of guanyuan (Ren 4) and Baihui (Du 20) in the treatment of 500 cases of enuresis Effect of acupuncture on bronchial asthma Acupuncture treatment of chronic rhinitis in 75 cases Immediate antiasthmatic effect of acupuncture in 192 cases of bronchial asthma Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases Clinical and experimental study on yifei jianshen mixture in preventing and treating infantile repetitive respiratory infection Clinical investigation on massage for prevention and treatment of recurrent respiratory tract infection in children Pneumococcal conjugate vaccine for young children Prevention of asthma morbidity: recent advances
    • keywords: 143; acupuncture; acupuncture treatment; acute; add; adhd; adults; adverse; age; agents; ages; airway; allergic; allergy; alternative; american; antibiotics; aom; asthma; asthmatic; atopic; attention; autism; bacterial; behavioral; beneficial; biofeedback; bladder; blind; breast; breastfeeding; bronchial; cam; care; cases; cause; cells; changes; childhood; children; children ages; chinese; chiropractic; chiropractic treatment; chronic; clinical; clinical study; clinical trial; cold; colic; common; comparison; complementary; conditions; control; controversial; conventional; cure; data; decrease; deficit; dermatitis; detrusor; development; diagnosis; diarrhea; dietary; differences; different; disease; disorder; double; drugs; duration; dysfunction; early; eczema; eeg; effective; effectiveness; effects; efficacy; effusion; enuresis; episodes; evaluation; evidence; family; fed; feeding; follow; formula; frequency; general; group; health; herbal; herbs; high; homeopathic; homeopathic treatment; human; hyperactive; hyperactivity; hypnosis; hypnotherapy; illness; illnesses; immune; immunization; important; improvement; incidence; increase; infantile; infants; infections; inflammation; inflammatory; large; laser; literature; long; lower; majority; management; manipulation; massage; measles; media; medical; medication; medicine; methods; middle; milk; months; nasal; natural; new; nights; nocturnal; nocturnal enuresis; non; normal; number; otitis; pain; parents; pathogenesis; pathogens; patients; pediatric; pertussis; physicians; pilot; placebo; points; population; possible; potential; practitioners; prevalence; prevention; primary; prospective; randomized; rate; recent; recurrent; reduction; related; relationship; relaxation; remedies; report; research; resistance; respiratory; response; results; review; rhinitis; risk; role; rsv; safety; school; scientific; self; severity; short; significant; specific; states; studies; study; success; successful; supplementation; support; survey; symptoms; system; tcm; term; therapeutic; therapies; therapy; time; touch; tract; traditional; training; treatment; treatment group; trial; u.s; united; upper; uri; use; vaccination; vaccine; viral; virus; viruses; visits; vitamin; weeks; worldwide; years; young
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23. cord-022520-ebj51v9o
    • author: Marini, Robert P.
    • title: Biology and Diseases of Ferrets
    • date: 2007-09-02
    • words: 19517
    • flesch: 43
    • summary: Paper presented at the 90th Meeting of the American Veterinary Medical Association Salmonella infections in mink and ferrets The experimental transmission of a virus causing hypergammagloblinemia in mink: sources and modes in infection Meningeal cryptococcosis and congestive cardiomyopathy in a ferret The Biomedical Use of Ferrets in Research The Universities Federation for Animal Welfare Handbook on the Care and Management of Laboratory Animals Endocrine factors in hematological changes seen in dogs and ferrets given estrogens Cryptosporidiosis in the dog and cat Dematologic diseases Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery A Practitioner's Guide to Rabbits and Ferrets Recurrent Mycobacterium bovis infection following a ferret bite Cell mediated immunity in ferrets: delayed dermal hypersensitivity, lymphocyte transformation, and macrophage migration inhibitory factor production Experimental transmission of Aleutian disease with urine Enteric coccidial infections Heartworm infections Treatment of proliferative colitis in ferrets Current Veterinary Therapy 11 Haematological and serum chemistry profiles of ferrets (Mustela putorius furo) Biology and Diseases of the Ferret Cutaneous lymphoma in a ferret (Mustela putoriusfuro) The pathogenesis, pathology, and diagnosis of the disease in experimentally infected ferrets The Clinical Chemistry of Laboratory Animals Derivation of gnotobiotic ferrets: perinatal diet and hand-rearing requirements Lack of detectable blood groups in domestic ferrets: implications for transfusion Distribution of technetium 99m-labeled red blood cells during isoflurane anesthesia in ferrets Ranitidine-bismuth citrate and clarithromycin, alone or in combination, for eradication of Helicobacter mustelae infection in ferrets The effect of isoflurane on hematologic variables in ferrets The Biomedical Use of Ferrets in Research Congenital malformations and variations in reproductive performance in the ferret: effects of maternal age, color, and parity Dirofilariasis in a ferret Dirofilariasis in a ferret Use of the ferret in cardiovascular research Current Therapy in Theriogenology Soft tissue surgery Demodiciasis in ferrets (Mustela putorius furo)
    • keywords: abdominal; abscesses; acid; acute; administration; adrenal; adult; adv; affected; age; aleutian; alopecia; anemia; animals; anorexia; antibiotic; antibody; appropriate; associated; avium; bacterial; bell; biology; biomedical; black; blood; body; bovis; bowel; box; breeding; brown; campylobacter; canine; care; carotene; cases; cats; cause; cell; cesarean; changes; characterized; chronic; clinical; clinical signs; coburn; coli; colony; commercial; common; condition; contact; control; cryptosporidiosis; culture; cycle; daily; dark; days; definitive; development; diagnosis; diarrhea; diet; differential; direct; discharge; disease; distemper; dogs; domestic; dose; early; effective; elevated; energy; enlargement; eosinophilic; epithelial; epizootiology; eradication; erdman; estrus; et al; etiology; evident; examination; experimental; exposure; facility; failure; fast; fat; fecal; feces; feeding; females; ferrets; fig; findings; flea; fluid; food; footed; form; fox; fox et; free; furo; gastric; gastritis; gastroenteritis; gastrointestinal; gestation; glands; gorham; gram; healthy; heartworm; heat; helicobacter; hepatic; high; hill; histologic; hormone; humans; important; induced; infected; infection; infestation; inflammation; influenza; inoculation; intestinal; isolated; isolation; jejuni; jills; kits; laboratory; large; lesions; lethargy; light; like; litters; liver; long; loss; lung; lymphoma; males; mastitis; mild; milk; mink; mites; model; months; morris; mucosa; mustelae; mycobacterium; nasal; natural; necropsy; negative; neoplasia; nest; new; nodes; normal; old; oocysts; oral; orcutt; organism; outbreak; parturition; perfringens; phase; photoperiod; pneumonia; potential; pregnancy; presence; present; production; proliferative; protein; pruritus; putorius; pylori; rabies; report; reproductive; research; respiratory; result; risk; rosenthal; rotavirus; salmonella; secondary; section; sensitivity; serum; short; signs; similar; size; skin; small; species; specific; spleen; splenomegaly; spp; strains; studies; study; supportive; surgical; susceptible; syndrome; systemic; testing; therapy; time; tissue; toxemia; tract; transmission; treatment; tuberculosis; tumors; type; typhimurium; ulcers; use; vaccination; vaccine; variety; veterinary; virus; vomiting; water; weeks; weight; years; young
    • versions: original; plain text
24. cord-022526-j9kg00qf
    • author: Jones, Samuel L.
    • title: Disorders of the Gastrointestinal System
    • date: 2009-05-18
    • words: 108877
    • flesch: 36
    • summary: Abdominal radiographs are reserved for smaller horses and ponies. In addition, one may detect mineral opacity within the colon on abdominal radiographs, particularly in foals, ponies, and small horses.
    • keywords: abdomen; abdominal; abdominocentesis; abnormalities; abscesses; absence; absorption; accumulation; acid; acidosis; activation; active; activities; activity; acute; addition; adenosine; adequate; adhesion; adjacent; administration; adult horses; adverse; affected; affected horses; agents; alimentary; alterations; amounts; anaerobic; analgesic; analysis; anaphylaxis; anastomosis; anemia; animals; anorexia; antagonist; antibiotics; antibodies; antibody; antiinflammatory; antimicrobial; apical; apparent; appearance; appropriate; area; arsenic; arterial; assessment; associated; association; attributable; auscultation; available; azotemia; bacteria; barrier; base; basement; beings; beneficial; benefit; bicarbonate; bile; binding; biochemical; biopsies; biopsy; bleeding; blockade; blood; blood cells; blood flow; body; bolus; borborygmi; bowel; broad; calcium; cantharidin; capillary; carbohydrate; carcinoma; cardiac; cardiovascular; care; cascade; cases; cause; cavity; cecum; cells; cellular; certain; cervical; chain; changes; characteristic; characterized; cheek; chloride; chronic; circulation; clear; clinical; clinical cases; clinical signs; clinician; clinicopathologic; clostridiosis; clostridium; coagulation; colic; colitis; colloid; colon; colonic; colonization; combination; common; complement; complete; complex; complications; components; compromised; concentration; conditions; congenital; contact; contamination; contents; contraction; contrast; control; core; correction; count; course; cox-2; cranial; critical; crypt; culture; cyathostomiasis; cyclic; cyclooxygenase; cytokines; cytologic; daily; damage; data; days; death; decreased; defect; defense; deficiency; definitive; degree; dehydration; delayed; dental; depression; detection; development; diagnosis; diaphragmatic; diarrhea; dietary; different; difficile; difficult; diffuse; digestive; dilation; direct; disease; disorders; displacement; disruption; distal; distended; distention; diverticula; dorsal; dosage; dose; dpj; drugs; duodenal; duodenum; duration; dysfunction; dysphagia; early; edema; effective; effects; efficacy; ehrlichia; electrolyte; elevated; emptying; endoscopic; endothelial; endothelial cells; endotoxemia; endotoxin; energy; enteric; enteritis; enterocolitis; enterocytes; enteroliths; enteropathy; enterotoxin; entrapment; environment; enzyme; eosinophilic; epiploic; epithelial; equine; equine intestinal; equine large; equine small; erythromycin; esophageal; esophageal obstruction; esophagitis; esophagus; evaluation; events; evidence; evident; examination; example; excessive; exists; experimental; exploration; exposure; extensive; extent; factors; failure; fatal; fatty; features; fecal; feces; feeding; fermentation; fever; fibrinogen; figure; findings; flexure; flora; flow; fluid; flunixin; foals; food; foramen; foreign; form; formation; free; frequent; function; gastric; gastric fluid; gastric mucosa; gastric ulceration; gastroesophageal; gastrointestinal; gastrointestinal disease; gastrointestinal tract; general; glands; glandular; glucose; good; gram; granulomatous; grass; greater; group; growth; hay; healing; healthy; heart; hematologic; hemorrhage; heparin; hernia; high; higher; histamine; history; horse fever; horses; host; hours; human; hypertonic; hypertrophy; hypoalbuminemia; hypocalcemia; hyponatremia; hypoproteinemia; idiopathic; iii; ileal; ileocecal; ileus; imbalances; immune; immunity; immunoglobulin; impaction; impaired; important; incidence; incisor; increase; induced; infected; infection; infiltration; inflamed; inflammation; inflammatory; inflammatory cells; inflammatory response; influence; infusion; ingesta; inguinal; inhibition; inhibitors; initial; injured; injury; intact; integrins; integrity; interaction; intermittent; intervention; intestinal; intestinal disease; intestinal distention; intestinal ileus; intestinal inflammation; intestinal injury; intestinal motility; intestinal mucosa; intestinal obstruction; intestinal strangulation; intestinal surgery; intestinal tissue; intestinal tract; intracellular; intraluminal; intravenous; intussusception; invasion; investigation; involved; involvement; ischemia; isolated; jejunum; junctions; key; kinase; known; laboratory; lack; lactate; lactic; laminitis; laparotomy; large; large colon; large intestine; larvae; lavage; layer; lbp; left; length; lesions; leukocytes; leukopenia; leukotrienes; levels; lidocaine; likely; limited; lipid; lipopolysaccharide; lips; little; liver; local; location; long; longer; loss; losses; lower; lumen; luminal; lymphoma; lymphosarcoma; macrophages; maintenance; major; malabsorption; management; mandibular; mare; mass; masses; massive; mast; material; matrix; means; mechanical; mechanisms; mediators; medical; megaesophagus; meglumine; membrane; mesenteric; metabolic; method; metoclopramide; mice; migration; mild; minutes; models; moderate; molecules; monitoring; monocytes; months; morphologic; motility; mouth; movement; mucosal; mucosal blood; mucosal injury; mucous; multiple; mural; muscle; muscular; nasogastric; natural; nature; necessary; necrosis; need; negative; neonatal; neoplasia; nerves; nervous; neural; neurologic; neutropenia; neutrophils; nitric; nodes; nonspecific; nonsteroidal; normal; normal horses; nsaids; number; nutritional; observed; obstruction; occlusal; occurring; oil; older horses; oncotic; onset; oral; organisms; organs; outcome; output; overall; overload; oxide; oxygen; pain; palpable; palpate; palpation; parasite; parietal; parotid; partial; particular; passage; pathogenesis; pathogens; pathologic; pathophysiology; pathway; patients; pattern; pcr; peak; pelvic; peptides; perfringens; period; peripheral; peritoneal; peritoneal fluid; peritonitis; permeability; pge; phagocytes; pharyngeal; phase; phenylbutazone; physical; plasma; platelet; poi; polymyxin; ponies; poor; population; portion; position; positive; possible; postoperative; potassium; potential; potomac; presence; present; pressure; prevalence; prevention; primary; problem; procedure; process; processes; production; products; profound; prognosis; progressive; prokinetic; prolapse; proliferative; prolonged; properties; prostaglandins; protective; protein; proximal; pulp; pyloric; radiography; range; rapid; rare; rate; reaction; reactive; recent; receptor; recovery; rectal; rectum; reduced; reflux; region; related; release; removal; renal; repair; reperfusion; replacement; reported; reports; resection; resistance; resolve; respiratory; response; responsible; restitution; result; retrospective; review; right; risk; risticii; role; roughage; rule; rupture; salivary; salmonella; salmonellosis; samples; sand; scintigraphy; secondary; secretion; secretory; segment; selective; sensitive; sensitivity; sensory; sepsis; septic; septicemia; series; serosal; serum; severe; severe cases; severity; shock; short; signaling; significant; signs; similar; simple; single; site; size; small colon; small intestinal; smooth; sodium; soft; soluble; solution; sounds; source; space; species; specific; spectrum; sphincter; spleen; spp; squamous; stage; stimulation; stomach; strangulated; strangulating; strictures; strongylosis; studies; study; submucosa; subsequent; successful; sufficient; supply; support; surface; surgery; surgical; survival; susceptible; swallowing; sympathetic; syndrome; synthesis; synthetic; systemic; systems; technique; teeth; term; tests; tgf; therapeutic; therapy; thickness; thoroughbred; thrombosis; time; tissue; tnf; tolerance; tongue; tooth; total; toxic; toxicity; toxins; tract; transit; transport; trauma; treatment; trefoil; tube; tumor; type; ulceration; ulcers; ultrasonography; underlying; unknown; upper; urine; useful; value; variable; varies; variety; vascular; vasculature; ventral; vessels; veterinary; villous; visceral; vitro; vivo; volume; volvulus; vulgaris; wall; water; weeks; weight; white; wound; xylose; years; young horses
    • versions: original; plain text
25. cord-022555-a7ie82fs
    • author: None
    • title: Digestive System, Liver, and Abdominal Cavity
    • date: 2011-12-05
    • words: 66503
    • flesch: 46
    • summary: The worm is transmitted to other cats that ingest the vomitus of an infected cat. Other cats should not be allowed to ingest infected vomit.
    • keywords: abdomen; abdominal; abnormalities; absorption; accumulation; acid; acute; addition; adenocarcinoma; administration; adult; adult cats; adverse; affected; affected cats; agents; ammonia; anal; anemia; anesthesia; animals; anorexia; antibiotic; antiemetic; antigen; anus; apparent; appearance; approach; appropriate; areas; ascites; aspiration; assessment; associated; association; author; available; bacterial; balloon; barium; base; beneficial; benefit; best; bile; biliary; bilirubin; biochemistry; biopsies; biopsy; bladder; bleeding; blood; bodies; body; bowel; bowel disease; box; breed; care; cases; cats; cats clinical; cats present; cause; cavity; cell; cell lymphoma; changes; chapter; chlorambucil; choice; cholangitis; cholestasis; chronic; chronic disease; cisapride; clinical; clinical signs; clinician; cobalamin; coli; colon; colonic; combination; common; complete; complications; concentrations; concurrent; condition; congenital; constipation; contaminated; contrast; control; corticosteroids; course; cryptosporidium; culture; cysts; cytology; daily; damage; days; definitive; degree; dehydration; detection; development; diabetes; diagnosis; diameter; diarrhea; diet; dietary; different; difficult; diffuse; dilation; direct; discrete; disease; disorders; distal; distention; dogs; dose; dosing; drug; duct; duodenalis; duodenum; duration; dysfunction; eating; effective; effects; effusion; electrolyte; elevated; emptying; endoscopy; enteric; environment; enzymes; epi; esophageal; esophageal disease; esophagitis; esophagus; essential; evaluation; evidence; examination; example; exocrine; extrahepatic; factors; failure; fat; fecal; feces; feeding; feline; feline liver; felis; fenbendazole; fever; fiber; figure; findings; fip; flotation; fluid; fna; foetus; folate; following; food; foreign; foreign bodies; foreign body; form; formation; fpli; frequency; frequent; fresh; function; gall; gallbladder; gastric; gastric disease; gastritis; gastroesophageal; gastrointestinal; gastrointestinal disease; general; giardia; gondii; good; grade; greater; guidelines; healthy cats; heart; helicobacter; help; helpful; hepatic; hepatic disease; hepatobiliary; high; higher; histologic; histopathologic; history; host; hours; humans; hypertension; ibd; ibds; identification; idiopathic; illness; imaging; immune; immunoreactivity; important; increased; indicator; individual; induced; infected; infection; infective; infiltration; inflammation; inflammatory; ingestion; initial; injury; insufficiency; intake; intermittent; interpretation; intestinal; intestinal obstruction; intussusception; involved; involvement; isospora; kittens; laboratories; laboratory; laparotomy; large; larvae; length; lesions; lethargy; levels; life; likely; limited; linear; lipase; lipidosis; liquid; litter; liver; liver disease; location; long; longer; loss; low; lower; lymphocytic; lymphoma; lymphosarcoma; management; mass; masses; mast; mean; median; medical; medications; megacolon; megaesophagus; mellitus; metabolism; method; metoclopramide; metronidazole; mild; minutes; moderate; modified; months; motility; mucosal; mucus; multiple; muscle; necessary; necrosis; needle; negative; neoplasia; nodes; nonspecific; normal; normal cats; note; novel; number; nutritional; object; obstruction; older cats; onset; oocysts; oral; organism; organs; owner; pain; palpable; pancreas; pancreatic; pancreatic disease; pancreatitis; paper; parasite; partial; pathology; patients; pcr; perforation; period; peritoneal; peritonitis; physical; placement; plasma; point; poor; population; portal; positive; possible; potential; practice; precise; prednisolone; presence; present; presentation; presenting; pressure; prevalence; primary; prior; problems; procedure; process; production; prognosis; prokinetic; prolonged; protein; proximal; radiographs; range; rare; rates; recent; receptors; rectum; recurrent; reflux; regurgitation; removal; renal; reported; reports; resection; resistance; response; result; review; right; risk; role; routine; rule; rupture; safe; samples; secondary; secretion; self; sensitive; sensitivity; septic; series; serum; severe; severity; shedding; siamese cats; significant; signs; similar; simple; single; size; skin; small; small cell; small intestinal; smooth; solution; species; specific; spectrum; sphincter; spontaneous; spp; steps; stomach; stricture; strongyloides; studies; study; subsequent; supplementation; supportive; surgery; surgical; survey; survival; syndrome; system; systemic; table; technique; term; testing; tests; therapy; thickening; time; tissue; total; tract; transmission; transudates; trauma; treatment; trichobezoars; tritrichomonas; trophozoites; tube; tumors; type; typical; ulceration; ulcers; ultrasonography; ultrasound; uncommon; underlying; united; unknown; unwell; urinary; urine; useful; variable; vascular; veterinary; vitamin; volume; vomiting; wall; water; weeks; weight; wet; worms; years; young; younger cats; zoonotic
    • versions: original; plain text
26. cord-022754-ehq9qnoo
    • author: None
    • title: Liver
    • date: 2012-07-25
    • words: 87936
    • flesch: 36
    • summary: Fad or future of liver disease? Copper-induced hepatitis: the COMMD1 deficient dog as a translational animal model for human chronic hepatitis Copper-associated liver disease Esteller A: Physiology of bile secretion Coagulation disorders in dogs with hepatic disease Current cytochrome P450 phenotyping methods applied to metabolic drug-drug interaction prediction in dogs Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes P50 Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat, and horse Cytochrome P450s and other enzymes in drug metabolism and toxicity mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates Modulation of acetaminopheninduced hepatotoxicity by the xenobiotic receptor CAR Increased free cortisol in plasma of dogs with portosystemic encephalopathy Chronic glucocorticoid excess and impaired osmoregulation of vasopressin release in dogs with hepatic encephalopathy GABAergic inhibition of the pituitary release of adrenocorticotropin and melanotropin is impaired in dogs with hepatic encephalopathy Liver sinusoidal endothelial cells: a new type of organ-resident antigen-presenting cell Characterisation of 11 beta-hydroxysteroid dehydrogenases in feline kidney and liver Central hypertensinogenic effects of glycyrrhizic acid and carbenoxolone Feline lower urinary tract diseases Metabolic and genetic aspects of urate urolithiasis in Dalmatians Hypoglycemia associated with nonislet cell tumor in 13 dogs The origins and kinetics of bilirubin in dogs with hepatobiliary and haemolytic diseases Bilirubin metabolism in canine hepatobiliary and haemolytic disease Plasma coagulation factor abnormalities in dogs with naturally occurring hepatic disease Alterations of prothrombin time and activated partial thromboplastin time id dogs with hepatic disease Correlation between coagulation profile findings and bleeding complications after ultrasoundguided biopsies: 434 cases (1993-1996) Use of a test for proteins induced by vitamin K absence or antagonism in diagnosis or anticoagulant poisoning in dogs HP: Circulatory disorders of the liver in dogs and cats Diagnostic value of fasting plasma ammonia and bile acid concentrations in identification of portosystemic shunting in dogs Evaluation of ammonia measurements in dogs with two analysers for use in veterinary practice Ultrasonographic findings in dogs with hyperammonemia: 90 cases Comparative studies on plasma and tissue sorbitol, glutamic, lactic and hydroxybutyric dehydrogenase and transaminase activities in the dog Pharmacokinetics of liver transaminases in healthy dogs: potential clinical relevance for assessment of liver damage Plasma and tissue enzyme activities in the cat Hepatic clearance of rat liver aspartate aminotransferase isozymes: evidence for endocytotic uptake via different binding sites on sinusoidal liver cells Effects of phenobarbital treatment on serum thyroxine and thyroid-stimulating hormone concentrations in epileptic dogs Lobular dissecting hepatitis in juvenile and young adult dogs Differential expression of copper-associated and oxidative stress related proteins in a new variant of copper toxicosis in Doberman Pinschers Chronic active hepatitis in 26 Doberman Pinschers Improvement in liver pathology after 4 months of D-penicillamine in 5 Doberman Pinschers with subclinical hepatitis Subclinical versus clinical hepatitis in the Doberman: Evaluation of changes in blood parameters Copper-associated hepatopathies in dogs Hepatitis and copper accumulation in Skye Terriers Part I. Differential diagnosis Glomerular filtration rate and renal volume in dogs with congenital portosystemic vascular anomalies before and after surgical ligation Morphology of congenital portocaval shunts in dogs and cats Congenital interruption of the portal vein and caudal vena cava in dogs: six case reports and a review of the literature Functional closure of the ductus venosus during early postnatal life in the dog The anatomy and embryology of portosystemic shunts in dogs and cats Portal hypertension associated with primary hypoplasia of the hepatic portal vein in dogs Budd-Chiari syndrome) as a cause of ascites in a cat Use of endovascular stents in three dogs with Budd-Chiari syndrome Characterization of hepatoportal microvascular dysplasia in a kindred of cairn terriers Ultrasonographic identification and characterization of congenital portosystemic shunts and portal hypertensive disorders in dogs and cats Gross anatomy of the canine portal vein Portal hypertension Part I. Pathophysiology and clinical consequences Ultrasonographic evaluation of partially attenuated congenital extrahepatic portosystemic shunts in 14 dogs Polycystic kidney and liver disease in cats Acquired portosystemic shunting in 2 cats secondary to congenital hepatic fibrosis Portal hypertension in a dog due to circumscribed fibrosis of the wall of the extrahepatic portal vein Ultrasonographic diagnosis of unusual portal vascular abnormalities in two cats Thrombosis of the portal vein in eleven dogs Heterobilharzia americana infection in a dog Multiple congenital portal vein anomalies in a dog Intraoperative ultrasonography of the portal vein during attenuation of intrahepatic portocaval shunts in dogs Portosystemic communications in the dog Nutritional aspects of the management of chronic hepatic encephalopathy Alterations of GABA-A and dopamine D-2 brain receptors in dogs with portal-systemic encephalopathy Clinical presentation and management of moxidectin toxicity in two dogs Generalized motor seizures after portosystemic shunt ligation in dogs: five cases Nutritional support for dogs and cats with hepatobiliary disease Effects of a branched chain amino acid-enriched diet on chronic hepatic encephalopathy in dogs Cerebrospinal fluid glutamine, tryptophan, and tryptophan metabolite concentrations in dogs with portosystemic shunts Evaluation of twelve-hour preprandial and two-hour postprandial serum bile acids disease in dogs Hematologic changes associated with serum and hepatic iron alterations in dogs with congenital portosystemic vascular anomalies Characterization of iron status in young dogs with portosystemic shunt Iron status and erythrocyte volume in dogs with congenital portosystemic vascular anomalies Hemostatic profiles in 39 dogs with congenital portosystemic shunts Coagulation profiles in dogs with congenital portosystemic shunts before and after surgical attenuation Standard planes for ultrasonographic examination of the portal system in dogs Szatmári V: Ultrasonography of portosystemic shunting in dogs Doppler studies before, during and after surgery Ultrasonographic assessment of hemodynamic changes in the portal vein during surgical attenuation of congenital extrahepatic portosystemic shunts in dogs Use of transcolonic 99mtechnetium-pertechnetate as a screening test for portosystemic shunts in dogs Quantification of portosystemic shunting in dogs by ultrasound-guided injection of 99m Tc-macroaggregates into a splenic vein Portal vein anomalies in the dog: their angiographic diagnosis Use of intraoperative mesenteric portovenography in congenital portosystemic shunt surgery Helical computed tomographic angiography of canine portosystemic shunts Three-dimensional multiscale helical computed tomography techniques for canine extra-hepatic portosystemic shunt assessment Use of magnetic resonance angiography for diagnosis of portosystemic shunts in dogs Brain magnetic resonance imaging characteristics in dogs and cats with congenital portosystemic shunts Medical management of animals with portosystemic shunts Improvement of chronic hepatic encephalopathy in dogs by the benzodiazepine-receptor partial inverse agonist sarmazenil, but not by the antagonist flumazenil Apparent dietary protein requirement of dogs with portosystemic shunt Medical management of congenital portosystemic shunts in 27 dogs -a retrospective study Ultrasonographic diagnosis of congenital portosystemic shunt in 14 cats Increasing incidence of hereditary intrahepatic portosystemic shunts in Irish Wolfhounds in the Netherlands (1984 to 1992) Determination of inheritance of single congenital portosystemic shunts in Yorkshire Terriers Inherited congenital extrahepatic portosystemic shunts in cairn terriers Detection of the single nucleotide polymorphism causing feline autosomal-dominant polycystic kidney disease in Persians from the UK using a novel real-time PCR assay Diagnostic value of fasting plasma ammonia and plasma bile acid concentrations in the identification of portosystemic shunting in dogs Hyperammonemia due to a urea cycle enzyme deficiency A suspected case of ornithine transcarbamylase deficiency in a cat Transient metabolic hyperammonaemia in young Irish Wolfhounds Hyperammonemia associated with urethral obstruction in a dog Ammonia intoxication in the near-adult cat as a result of a dietary deficiency of arginine Cobalamin deficiency associated with methylmalonic acidemia in a cat Hyperammonaemic encephalopathy secondary to selective cobalamin deficiency in a juvenile Border collie Transient hyperammonemia in an adult German Shepherd dog Evaluation of bile acid concentrations for the diagnosis of portosystemic venous anomalies in the dog and cat Epidemiologic factors associated with the anatomic location of intrahepatic portosystemic shunts in dogs Association of breed with the diagnosis of congenital portosystemic shunts in dogs: 2400 cases Ammonia tolerance test in clinically normal dogs and in dogs with portosystemic shunts Rectal ammonia tolerance test in the evaluation of portal circulation in dogs with liver disease Postprandial venous ammonia concentration in the diagnosis of hepatobiliary disease in dogs Long-term biochemical and physiologic effects of surgically placed portocaval shunts in dogs Outcome of ameroid constrictor occlusion of single congenital extrahepatic portosystemic shunts in cats: 12 cases Evaluation of ameroid ring constrictors for the management of single extrahepatic portosystemic shunts in cats: 23 cases Clinicopathologic features of primary and metastatic neoplastic disease of the liver in dogs A retrospective study of 395 feline neoplasms A survey of feline neoplasms Hepatobiliary neoplasia in dogs and cats Tumors of the liver and gallbladder Small Animal Clinical Oncology Primary neoplasms in dog liver induced by diethylnitrosamine Translation of new cancer treatments from pet dogs to humans The establishment and characterization of the first canine hepatocellular carcinoma cell line, which resembles human oncogenic expression patterns Immunohistochemical characterization of canine hyperplastic hepatic lesions and hepatocellular and biliary neoplasms with monoclonal antibody hepatocyte paraffin 1 and a monoclonal antibody to cytokeratin 7 Canine hepatic neuroendocrine carcinoma: an immunohistochemical and electron microscopic study Canine biliary carcinoma: epidemiological comparisons with man Comparative analysis of hepatocellular carcinoma in men and dogs Inactivation of TGFbeta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy MDM2 and p53 polymorphisms are associated with the development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection Epidermal growth factor-induced hepatocellular carcinoma: gene expression profiles in precursor lesions, early stage and solitary tumours Identification of hepatic stem/progenitor cells in canine hepatocellular and cholangiocellular carcinoma Withrow and MacEwen's Small Animal Clinical Oncology Status epilepticus after ligation of portosystemic shunts Progressive remission of portosystemic shunting in 23 dogs after partial closure of congenital portosystemic shunts Gradual occlusion of extrahepatic portosystemic shunts in dogs and cats using the ameroid constrictor Methods of gradual vascular occlusion and their applications in treatment of congenital portosystemic shunts in dogs: a review A method for controlling portal pressure after attenuation of intrahepatic portocaval shunts Gauged attenuation of congenital portosystemic shunts: results in 160 dogs and 15 cats Evaluation of cellophane banding with and without intraoperative attenuation for treatment of congenital extrahepatic portosystemic shunts in dogs Cellophane banding for the gradual attenuation of single extrahepatic portosystemic shunts in eleven dogs Outcomes of cellophane banding for congenital portosystemic shunts in 106 dogs and 5 cats Evaluation of the characteristics of venous occlusion after placement of an ameroid constrictor in dogs Evaluation of ameroid ring constrictors for treatment for single extrahepatic portosystemic shunts in dogs: 168 cases Evaluation of a portocaval venograft and ameroid ring for the occlusion of intrahepatic portocaval shunts in dogs Surgical management of left divisional intrahepatic portosystemic shunts: outcome after partial ligation of, or ameroid ring constrictor placement on, the left hepatic vein in twenty-eight dogs Laparoscopic portosystemic shunt attenuation in two dogs Transvenous coil embolization of portosystemic shunt in dogs Transjugular coil embolisation of an intrahepatic shunt in a cat Complications associated with the diagnostic, medical, and surgical management of portosystemic shunts Portal vein thrombosis as a complication of portosystemic shunt ligation in two dogs Neurologic dysfunction in dogs following attenuation of congenital extrahepatic portosystemic shunts Neurologic dysfunction in three dogs and one cat following attenuation of intrahepatic portosystemic shunts Use of propofol to manage seizure activity after surgical treatment of portosystemic shunts Portal hypertension Part II: Clinical assessment and treatment Diagnostic comparison of needle and wedge biopsy specimens of the liver in dogs and cats Magnetic resonance imaging of focal splenic and hepatic lesions in the dog Accuracy of ultrasound guided aspiration of the liver and cytologic findings in dogs and cats: 97 cases A multistep approach in the cytologic evaluation of liver biopsy samples of dogs with hepatic diseases Metronomic therapy with cyclophosphamide and piroxicam effectively delays tumor recurrence in dogs with incompletely resected soft tissue sarcomas Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature Sorafenib in advanced hepatocellular carcinoma: we have won a battle not the war Phase I dose escalating study of SU11654, a small molecule receptor tyrosine kinase inhibitor, in dogs with spontaneous malignancies Continuous low-dose oral chemotherapy for adjuvant therapy of splenic hemangiosarcoma in dogs Hepatic artery embolization and chemoembolization for treatment of patients with metastatic carcinoid tumors: the M.D. Anderson experience Percutaneous arterial embolization and chemoembolization for treatment of benign and malignant tumors in three dogs and a goat Treatment of unresectable hepatocellular adenoma in dogs with transarterial iodized oil and chemotherapy with and without an embolic agent: a report of two cases Results of partial hepatectomy in 18 dogs with hepatocellular carcinoma The pathology of liver tumours in the dog Partial hepatectomy in dogs Cancer of the liver Efficacy of mitoxantrone against various neoplasms in dogs Low-dose metronomic chemotherapy with cisplatin: can it suppress angiogenesis in H22 hepatocarcinoma cells?
    • keywords: abdominal; ability; abnormalities; absence; absent; absorption; accumulation; accuracy; acetaminophen; acids; activation; activities; activity; acute hepatic; acute liver; additional; administration; adult; advanced; affected dogs; aflatoxin; age; agents; alf; alkaline; alp; alt; alt activity; amino; ammonia; ammonium; analysis; anemia; anesthesia; angiography; animals; anomalies; anorexia; antibiotics; appearance; appropriate; apsc; areas; arginine; ascites; aspiration; assessment; associated; association; asymptomatic; attenuation; autoimmune; available; bacterial; bedlington; beneficial; benign; best; bile; bile acids; bile duct; biliary; biliary tract; bilirubin; biochemical; bleeding; blood; body; bone; brain; breed; breed dogs; canine; canine hepatic; canine liver; capacity; carcinoma; care; cases; cats; caudal; cause; cava; ccnu; cell; central; centrilobular; certain; changes; chapter; characteristic; characterization; characterized; chemotherapy; cholangiohepatitis; cholangitis; cholecystitis; cholestasis; cholestatic liver; cholesterol; chronic disease; chronic hepatitis; chronic liver; circulation; cirrhosis; clear; clinical; clinical disease; clinical findings; clinical liver; clinical signs; clinician; clotting; coagulation; coagulopathy; combination; common; common bile; common liver; comparison; complete; complications; concentrations; concurrent; conditions; congenital; congenital hepatic; conjugated; consequence; consistent; content; contrast; contribute; control; copper accumulation; copper concentrations; correlation; corticosteroids; cortisol; cpss; culture; cycle; cysts; cytologic; cytology; daily; damage; days; death; decreased; deficiency; definitive; degree; dependent; detection; determined; develop; development; diagnosis; diarrhea; dietary; different; difficult; diffuse; diffuse liver; dilation; direct; disease process; diseases; disorders; doberman; dogs; dogs hepatic; dogs liver; dogs serum; dose; drug; dry; duct; duration; early; effective; effects; effusion; ehbo; elevated; elevations; endogenous; endothelial; enlarged; enzyme activity; enzymes; essential; etiology; evaluation; evidence; examination; example; excess; excretion; exposure; expression; extrahepatic; extrahepatic disease; factors; fasting; fat; fatal; fatty; features; feeding; feline; feline hepatic; feline liver; female; fever; figure; findings; fine; flow; fluid; focal; following; food; form; free; frequent; functions; gallbladder; gastric; general; genetic; ggt; glucocorticoid; glucose; glutamine; glutathione; glycogen; good; granulomatous; greater; group; growth; half; hcc; healthy; healthy dogs; hemolysis; hemolytic; hemorrhage; hepatectomy; hepatic; hepatic abscesses; hepatic bile; hepatic biopsy; hepatic blood; hepatic copper; hepatic damage; hepatic disease; hepatic dysfunction; hepatic encephalopathy; hepatic enzyme; hepatic failure; hepatic fibrosis; hepatic inflammation; hepatic injury; hepatic insufficiency; hepatic involvement; hepatic lesions; hepatic lipidosis; hepatic mass; hepatic metabolism; hepatic necrosis; hepatic neoplasia; hepatic nodular; hepatic parenchyma; hepatic portal; hepatic synthesis; hepatic tissue; hepatic tumors; hepatitis; hepatobiliary disease; hepatocellular; hepatocytes; hepatomegaly; hepatopathies; hepatopathy; hepatotoxicity; herbal; high; higher; highland; histologic; histopathologic; history; hormone; hours; hscs; humans; hyperadrenocorticism; hyperammonemia; hyperbilirubinemia; hyperplasia; hypertension; hypoalbuminemia; hypoglycemia; hypothyroidism; icterus; identification; idiopathic; idiosyncratic; illness; imaging; immune; impaired; important; improvement; incidence; increased; individual; induced; induction; infection; inflammation; inflammatory; inflammatory liver; information; ingestion; initial; intestinal; intracellular; intrahepatic bile; invasive; involved; involvement; iron; jaundice; kidney; kupffer; laboratory; labrador; lack; laparoscopy; laparotomy; large; lead; left; leptospirosis; lesions; lethargy; levels; life; likely; limited; lipids; liver biopsies; liver biopsy; liver cancer; liver cell; liver copper; liver cytology; liver damage; liver disease; liver enzyme; liver failure; liver fibrosis; liver function; liver hepatic; liver injury; liver liver; liver lobe; liver mass; liver neoplasia; liver nodules; liver regeneration; liver tissue; liver tumors; lobes; lobular; long; loss; lower; lymphocytes; lymphoma; major; malignant; management; marker; mass; mean; measurement; mechanisms; medical; medication; membranes; metabolism; metabolites; metal; metastatic; method; mild; minutes; mixed; moderate; months; morphologic; mortality; mucoceles; multifocal; multiple; muscle; nac; necessary; needle; negative; neoplasia; neoplasms; neurologic; new; nodular; nodules; nonspecific; normal; normal dogs; normal liver; note; number; obstruction; occlusion; onset; optimal; oral; organ; origin; oxidative; p450; pancreatic; pancreatitis; parenchymal; parenchymal liver; partial; pathogenesis; pathology; patients; pattern; penicillamine; percutaneous; period; periportal; peritonitis; phase; phenobarbital; phosphatase; phpv; physical; pinschers; plasma; point; polycystic; poor; population; portal; portal blood; portal hypertension; portal vein; portal venous; portosystemic; portosystemic shunting; positive; possible; postprandial; potential; prehepatic; presence; present; presentation; pressure; primary; primary hepatic; primary liver; prior; procedure; process; processes; production; progenitor; prognosis; progressive; proliferation; prolonged; protein; radiographs; range; rare; reactions; reactive; recent; receptors; recovery; reduced; reference; regenerative; related; relationship; release; renal; reported; reports; reserve; resolution; response; result; retrievers; retrospective; review; right; risk; role; rupture; samples; sampling; sba; scintigraphy; screening; secondary; secretion; section; seizures; sensitive; sensitivity; serum; serum alt; serum bile; serum hepatic; serum liver; severe; severe hepatic; severe liver; severity; sex; shunting; shunts; significant; signs; similar; single; sinusoidal; site; size; small; small liver; source; spaniels; species; specific; specific hepatic; specificity; specimens; spleen; splenic; spontaneous; spp; stage liver; stages; stellate; steroid; storage; stress; studies; study; subclinical; substances; suggestive; sulfonamides; supplements; supportive; surgery; surgical; survival; symptoms; syndrome; synthesis; systems; table; target; techniques; term; terriers; test; testing; therapeutic; therapy; thrombocytopenia; thrombosis; thyroxine; time; tissue; total; toxicity; toxicosis; toxin; tract; tract disease; transport; transudate; treatment; tumors; type; typical; ultrasonography; ultrasound; underlying; unknown; urea; urinary; urine; useful; vacuolar; value; variable; variety; vascular; vasculature; vein; vena; venous; veterinary; virus; vitamin; volume; vomiting; wall; water; wedge; weeks; weight; west; white; years; young; young dogs; zinc
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27. cord-023165-f6o6owg3
    • author: NAVARRE, CHRISTINE B.
    • title: Diseases of the Gastrointestinal System
    • date: 2009-05-21
    • words: 24580
    • flesch: 53
    • summary: Unlike in other small animals, contrast techniques are not practical for characterizing small intestinal problems in sheep and goats because the rumen dilutes and slows passage of the contrast media. Using EDTA tubes made for small animals or shaking excess EDTA out of large tubes resolves this problem.
    • keywords: abdomen; abdominal; abomasal; abomasum; abscesses; acidosis; acute; administration; adult; affected; agents; amounts; analysis; anemia; anesthesia; animals; anorexia; anthelmintic; antimicrobial; anus; area; associated; atresia; authors; available; bacteria; beneficial; best; bid; biopsy; bloat; blood; body; calves; care; cases; cattle; caudal; cause; changes; chapter; choice; chronic; clinical; clinical signs; clinician; clinicopathologic; cobalt; coccidiostats; colic; collected; colon; colostrum; common; concentrations; condition; contamination; control; culture; cycle; damage; days; death; deficiency; dehydration; depression; deworming; diagnosis; diarrhea; diet; dietary; difficult; disease; distention; drugs; dry; effective; eggs; elevated; energy; environment; enzymes; epg; etec; ewes; examination; failure; fecal; feces; fed; feed; feeding; females; figure; flock; fluid; flukes; form; formation; free; frothy; gastrointestinal; general; glucose; goats; good; grain; grazing; gut; hay; helpful; high; host; hours; important; incidence; incision; increase; infected; infection; infective; ingestion; intake; intestine; johne; keepers; kids; lactic; lambs; large; larvae; left; levels; life; likely; limited; liver; liver disease; local; long; loss; low; management; method; mild; milk; mineral; mixed; months; motility; mucosa; negative; nematode; new; normal; numbers; obstruction; oral; organisms; outbreak; pain; parasites; pasture; pathogenesis; pattern; peritonitis; plants; poor; possible; presence; present; prevention; problem; procedure; production; prognosis; programs; prolapse; proper; protein; purse; quality; rectal; rectum; resistance; result; rumen; rumenitis; rumenotomy; ruminants; safe; salmonella; samples; secondary; serum; severe; sheep; signs; similar; skin; small; sodium; species; specific; stress; string; supportive; surgery; surgical; suture; systemic; technique; tests; therapy; time; tissue; toxemia; treatment; tube; type; ultrasonography; umbilical; useful; vaccination; values; wall; water; weeks; weight; year; young
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28. cord-023367-ujflw19b
    • author: Newcomer, Benjamin W.
    • title: Diseases of the hematologic, immunologic, and lymphatic systems (multisystem diseases) [Image: see text]
    • date: 2020-04-17
    • words: 33192
    • flesch: 48
    • summary: No treatment is available for border disease infection. Because blood gas analysis and exclusion of other diseases often are impractical, the term floppy kid syndrome frequently is used by owners to refer to any kid that is weak and does not have an overt, organ-specific sign (e.g., diarrhea).
    • keywords: abnormalities; abscesses; absorption; acidosis; acute; addition; adequate; administration; adult; affected; affected animals; agents; alpha; america; analysis; anemia; animals; anorexia; antibodies; antibody; areas; assays; associated; available; azotemia; bacteria; best; beta; bicarbonate; biopsy; birth; black; blood; body; bone; bovine; brain; caev; calves; care; cases; cattle; cause; cells; central; cervids; changes; chapter; characteristic; chronic; clinical; clinical disease; clinical signs; clostridium; colostrum; common; concentration; conditions; contact; contaminated; contamination; control; copper; counts; course; culture; damage; dams; days; dead; death; deer; definitive; dehydration; depression; diagnosis; diarrhea; different; difficult; direct; disease; disorder; drugs; early; edema; effective; effects; efforts; electrolyte; elisa; elk; endemic; enteritis; enterotoxemia; environment; erythrocytes; evidence; ewes; examination; exposure; factors; failure; fatal; fawns; fecal; feces; fed; feed; fever; findings; flock; fluids; foot; form; fpt; function; gastrointestinal; generalized; goats; good; gram; gut; head; healthy; help; hemoglobinuria; hemolysis; hemolytic; hemorrhagic; herd; high; higher; history; host; hours; humans; identification; igg; immature; immune; immunity; immunoglobulin; important; increased; individual; infected; infected animals; infection; inflammation; inflammatory; ingestion; internal; intestinal; invasion; isolation; kidding; kids; lambing; lambs; large; lead; lesions; life; likely; liver; local; loss; low; lower; lung; lymph; lymphoma; major; malignant; management; marrow; masses; mastitis; maternal; membranes; meq; metabolic; method; microscopic; mild; milk; months; morbidity; mortality; mouth; mucous; muscle; mycoplasma; nasal; necropsy; necrosis; necrotic; needle; negative; neonatal; neonates; nervous; neutrophils; new; newborn; nodes; normal; north; novyi; numbers; old; older; onset; oral; organism; outbreak; ovis; parasites; paratuberculosis; parts; parturition; passive; pathogenesis; pathogens; pcr; penicillin; perfringens; pneumonia; poor; positive; possible; postmortem; potential; pregnant; presence; present; prevention; production; proliferation; pulmonary; quality; rapid; rare; rates; rbc; recent; recumbency; red; related; reported; respiratory; response; results; risk; role; ruminants; samples; season; secondary; sepsis; septicum; serologic; serotypes; serum; severe; shed; sheep; short; signs; similar; sites; skin; small; sodium; soil; solutions; source; species; specific; spleen; spp; spread; states; stress; study; subcutaneous; sudden; supportive; surface; susceptible; syndrome; systemic; systems; testing; tests; therapy; time; tissue; total; toxemia; toxin; tract; transfer; transmission; treatment; type; uncommon; uncomplicated; united; urine; useful; vaccinated; vaccination; vaccines; vector; vein; vesicular; viral; virus; viruses; volume; water; weakness; weeks; weight; white; wild; wound; year; young
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29. cord-023528-z9rc0ubj
    • author: Wilkins, Pamela A.
    • title: Disorders of Foals
    • date: 2009-05-18
    • words: 42606
    • flesch: 40
    • summary: A syndrome of bronchointerstitial pneumonia and acute respiratory distress has been described in older foals and appears to be a distinct entity from acute respiratory distress syndrome in neonatal foals in association with sepsis. One can use these measurements and the ultrasonographic appearance of the internal umbilical structures from clinically normal foals as references to diagnose abnormalities of the umbilical structures in neonatal foals.
    • keywords: abdominal; ability; abnormalities; acid; acidosis; activity; acute; additional; adequate; administration; adult; affected foals; age; agents; air; airway; alloantibodies; angular; antibodies; antibody; antimicrobial; apnea; appearance; approach; appropriate; areas; arterial; arthritis; asphyxia; aspiration; associated; association; atresia; attempt; attention; author; available; bacterial; bandage; base; bearing; beneficial; benefit; best; bicarbonate; bilateral; birth; bladder; blood; blood gas; body; bone; brain; breathing; broad; cardiac; care; carpal; carpus; cartilage; cases; cause; cell; central; cerebral; changes; chest; choice; chronic; circulation; clinical; clinical signs; clinician; coaptation; colic; colostral; colostrum; combined; common; comparison; complete; concentration; condition; conformation; congenital; constant; control; correction; culture; current; dam; damage; days; death; decreased; defects; deformities; degree; delivery; depression; development; deviations; diagnosis; diarrhea; difficult; direct; disease; disorders; distal; distress; dopamine; dose; drug; dysfunction; early; edema; effective; effects; efficacy; electrolyte; encephalopathy; enteral; enterocolitis; environment; epinephrine; equine; erythrocytes; erythromycin; evaluation; evidence; examination; excessive; exercise; external; factors; failure; feces; feeding; fetal; fetlock; fetus; fever; field; findings; flexural; flow; fluid; fluid therapy; foal blood; foal syndrome; foals; foals clinical; foals failure; following; fpt; fractures; free; frequent; function; gastric; gastrointestinal; gestation; glucose; goal; good; greater; group; growth; healthy; heart; hie; high; history; horse foals; horses; hours; human; hypercapnia; hypertension; hypoxemia; hypoxia; igg; ill; ill foals; immunity; immunoglobulin; important; improved; incidence; increased; infants; infected; infection; infusion; initial; injury; inotrope; intensive; intracellular; intranasal; intravenous; involved; ischemic; isoerythrolysis; joint; kg foal; lack; lameness; large; lateral; laxity; left; length; lesions; levels; life; ligamentous; likely; limb; liver; loading; local; location; long; loss; losses; low; lung; magnesium; maintenance; management; mares; mass; maternal; mean; mechanical; meconium; medical; membrane; metabolic; mild; milk; moderate; monitor; months; mucosal; multiple; muscle; musculoskeletal; naloxone; necessary; need; negative; neonatal foals; neonatal isoerythrolysis; neonate; neurologic; newborn foals; nicu; normal; normal foals; nutritional; older foals; onset; organism; orthopedic; ossification; osteomyelitis; outcome; output; overload; oxygen; packed; parturition; passive; pathogens; pathophysiology; patients; pattern; perfusion; perinatal; period; periosteal; persistent; placental; plasma; pneumonia; poor; positive; possible; potential; pph; practitioners; pregnancy; premature; prematurity; presence; present; pressor; pressure; prevalence; previous; primary; problems; production; products; prognosis; prophylaxis; protein; proximal; pulmonary; radiographs; rare; rate; rats; receptor; rectum; recumbency; renal; reported; respiratory; response; result; resuscitation; retention; review; rhodococcus; risk; role; rotation; rupture; secondary; secretion; seizures; sepsis; septic; septic foals; serum; severe; severity; shock; short; significant; signs; similar; site; small; sodium; soft; source; specific; spectrum; splints; structures; studies; study; sucralfate; sulfate; support; supportive; surgery; surgical; survival; swelling; syndrome; system; systemic; table; tachycardia; tarsal; temperature; term; tests; therapeutic; therapy; thorax; thoroughbred; thought; time; tissue; total; tract; transfer; transfusion; transition; trauma; treatment; tube; type; ulceration; ulcers; ultrasonographic; umbilical; umbilicus; unknown; urinary; urine; uroperitoneum; use; useful; utero; valgus; values; vascular; vasopressin; ventilation; vessels; virus; vitamin; volume; wall; water; weeks; weight; white; years; young; young foals
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30. cord-023913-pnjhi8cu
    • author: Foreman, Stephen
    • title: Broader Considerations of Medical and Dental Data Integration
    • date: 2011-10-08
    • words: 47672
    • flesch: 38
    • summary: Over the past decade evidence has been building that there is a relationship between dental disease, particularly periodontal disease, and chronic illnesses. Dentists will need to be alert for early signs of chronic illness among their patients and physicians will need to be alert for signs of dental disease.
    • keywords: access; action; additional; adults; advanced; affected; aggressive; alleles; alternative; american; american dental; ammation; ammatory; analysis; annual; application; approach; appropriate; areas; arthritis; association; available; average; basic; benefi; benefi ts; better; bioterrorism; blood; blue; cancers; cardiovascular; cardiovascular disease; care costs; care providers; caries; case; causes; cavity; cell; center; central; certain; challenges; changes; childhood; children; chromosome; chronic; chronic disease; chronic health; chronic periodontal; ciency; cient; cigna; ckd; clear; clinical; clinical care; clinical data; clinical research; clinicians; clinics; cms; collaboration; colleagues; collection; common; communication; community; community health; complex; complications; comprehensive; computer; conditions; confi; consequences; consortium; control; coronary; costs; coverage; craniofacial; critical; cross; current; curriculum; data; database; day; death; decade; decision; defi; delivery; demonstration; dental; dental association; dental benefi; dental care; dental clinic; dental coverage; dental data; dental disease; dental education; dental electronic; dental health; dental informatics; dental insurance; dental patient; dental profession; dental providers; dental record; dental research; dental schools; dental services; dental students; dental treatment; dental visit; dentistry; dentists; department; design; detection; development; diabetes; diabetics; diagnosis; different; diffi; direct; disability; disease; disorders; dna; drug; early; economic; edr; educational; effective; effectiveness; effects; effi; efforts; ehr; ehrs; eld; electronic; electronic health; enamel; entire; entities; entry; environment; epigenetic; equivalent; essential; estimate; et al; evaluation; events; evidence; examination; example; exchange; existing; expenditures; experience; extended; extramural; factors; faculty; failure; families; family; federal; fhc; fig; focused; following; forms; foundation; fragile; frequency; function; future; general; genes; genetic; genome; gerd; gingival; good; government; greater; group; hand; head; health care; health center; health information; health insurance; health professionals; health record; health system; healthcare; heart; help; heritability; high; higher; history; home; hospitals; human; hygiene; hypertension; identifi; iehr; illness; impact; impairment; implementation; important; improved; incidence; increased; independent; individuals; industry; infarction; infectious; infl; information; initiative; institute; insurance coverage; integrated; integration; intellectual; involved; iom; issues; key; kidney; knowledge; lack; large; lead; learning; level; life; likely; limited; linkage; little; local; long; loss; low; lower; major; majority; making; management; mapping; markers; marshfi; mechanisms; medicaid; medicaid dental; medical; medical care; medical costs; medical health; medicare; medication; medicine; members; metabolic; methods; methylation; michigan; models; moderate; molecular; months; mother; mouth; multiple; myocardial; national; national health; ndings; necessary; ned; need; neurodevelopmental; new; new dental; non; number; numerous; offi; opportunities; opportunity; oral care; oral disease; oral health; outcomes; overall; pain; paper; particular; past; patient; patient care; patient information; patient record; patterns; pediatric; people; percent; periodontal disease; periodontitis; persons; phenytoin; physician; pipeline; plan; planning; point; policy; poor; population; portion; possible; potential; practice; practitioners; pregnancy; presence; present; preterm; prevalence; preventive; preventive dental; primary; primary care; private; private dental; private health; problem; process; professionals; program; progress; progression; project; providers; public health; purposes; quality; rare; recent; recommendations; record; reduction; refl; reform; related; relationship; report; research; researchers; residents; response; result; retinal; review; rheumatoid; risk; role; rst; rural; savings; scale; secondary; section; security; seizure; sequencing; services; set; severe; shared; sharing; signifi; signs; similar; single; sites; software; source; special; specifi; spending; standards; state; status; stroke; strong; structural; students; studies; study; substantial; success; support; surgeon; surveillance; survey; susceptibility; symptoms; syndrome; system; systemic; team; technologies; technology; teeth; terms; time; tool; tooth; total; training; traits; treatment; trials; type; underserved; uninsured; unique; united; university; use; value; variants; variation; visit; way; wide; willing; wong; work; workforce; years; � ¢
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31. cord-026009-rdhuc2n2
    • author: Anderson, Nancy L.
    • title: Pet Rodents
    • date: 2009-05-15
    • words: 14928
    • flesch: 56
    • summary: • Diagnosis is based on clinical signs, history, visualization of parasite, skin scrape, and cellophane tape test. • Clinical signs include erythema, pruritus, waxy debris, and excoriations behind the ears.
    • keywords: abdomen; abdominal; abscesses; administer; affected; alopecia; anesthesia; animals; anorexia; antibiotics; areas; available; bacterial; bedding; blood; bodies; breeding; cage; care; carriers; cases; cats; cause; check; chinchillas; chloramphenicol; chronic; clean; clinical; clinical signs; common; condition; conjunctivitis; contact; control; culture; days; death; dehydration; diagnosis; diarrhea; difficult; discharge; disease; dogs; drugs; dyspnea; ear; ears; epiphora; examination; failure; fecal; feces; feeding; females; fetuses; fig; fleas; fluids; food; foreign; fresh; gerbils; geriatric; gland; grave; gross; guinea; guinea pigs; hair; hamsters; hand; head; heart; high; history; hours; important; incisors; individuals; induction; infection; isolation; key; large; liver; long; loss; lymph; male; mammary; masses; mastitis; mice; mild; mites; mouse; necessary; necropsy; needle; neoplasia; normal; oral; otitis; pasteurella; patients; pet; pets; physical; pigs; place; pneumonia; point; poor; possible; pregnancy; presence; present; primary; produce; prognosis; pruritus; pseudomonas; radiographs; rate; rats; removal; respiratory; response; restraint; results; rodents; samples; sanitation; secondary; self; sensitivity; severe; signs; similar; size; skin; small; species; spp; streptococcus; stress; sulfa; supportive; surgical; survival; susceptibility; swelling; table; tail; tape; technique; teeth; term; testing; tetracycline; therapy; tilt; tip; tissue; tooth; topical; tract; transmission; trauma; treat; treatment; tube; tumors; urine; use; vaginal; viral; virus; vitamin; water; weeks; weight; work; young
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32. cord-026031-hnf5vayd
    • author: Ford, Richard B.
    • title: Emergency Care
    • date: 2009-05-21
    • words: 112481
    • flesch: 42
    • summary: animal patients. The normal CVP for small animal patients is 0 to 5 cm H 2 O. Values less than zero are associated with absolute or relative hypovolemia.
    • keywords: 2î±; abdomen; abdominal; abdominal pain; ability; abnormalities; absence; absorbent; absorption; access; accurate; acid; acidosis; activated; active; activity; acute; additional; adequate; adjacent; administer; administer intravenous; administration; adverse; affected; agents; aggressive; airway; albumin; allow; alveolar; ammonia; amounts; ampicillin; amylase; analgesic; analyses; anemia; anesthetic; animal; anorexia; antagonist; anterior; antibiotics; antidote; antiemetic; antiinflammatory; antimicrobial; antithrombin; antivenin; apparent; appearance; appropriate; aqueous; area; arrest; arterial; arterial blood; artery; aspect; aspiration; associated; ataxia; atrial; atrioventricular; atropine; attempt; aural; auscultation; available; azotemia; bacterial; bandage; base; beats; best; bicarbonate; bid; biochemical; bitch; bite; bladder; bleeding; block; blood; blood pressure; blunt; bodies; body; bolus; bone; bowel; box; bradycardia; brain; breathing; breeds; broad; bronchitis; burns; cage; calcium; calculated; canal; capillary; cardiac; cardiogenic; cardiomyopathy; cardiopulmonary; cardiovascular; care; careful; cases; cathartic; catheter; cats; caudal; cause; cavity; cells; cellular; central; cerebral; chamber; changes; characteristic; charcoal; chemical; chest; chf; chloride; choice; chronic; circulating; clean; clinical signs; clip; close; closure; clotting; cns; coagulation; coagulopathies; collapse; collar; colloid; color; coma; combination; common; complete; complexes; complications; component; compound; compressions; concentrated; concentration; concurrent; condition; congenital; congestive; conjunctival; consciousness; constant; contact; contamination; contents; contraindicated; control; contusions; cooling; cord; corneal; correct; correction; cotton; cough; count; course; cpcr; cranial; cri; critical; crystalloid; culture; cvp; cyanosis; cytologic; daily; damage; days; death; debridement; debris; decrease; deep; deficiency; deficit; definitive; degree; dehydration; delayed; delivery; dependent; depression; dermal; dermatitis; determined; develop; development; dexamethasone; dextrose; diagnosis; diaphragmatic; diarrhea; diazepam; differential; difficult; dilute; dioxide; direct; discharge; discomfort; disease; disk; disorders; distal; distress; diuresis; dogs; donor; dopamine; dorsal; dorsally; dose; drainage; drops; drugs; dry; duration; dysfunction; dysrhythmias; early; ecg; edema; edges; effective; effects; effusion; elbow; electrical; electrolyte; elevated; elizabethan; emergency; emesis; end; endotracheal; enrofloxacin; envenomation; environment; enzyme; epidural; epinephrine; equipment; esophageal; ethylene; evaluation; evidence; examination; example; excessive; excitation; excretion; exposure; extension; extent; external; extreme; eye; eyes; factor; failure; fall; favorable; feline; fever; fibrillation; figure; findings; flow; fluid; fluid therapy; flush; following; food; foreign; formation; forms; formula; fractures; free; frequent; fresh; frozen; function; furosemide; gastroenteritis; gastrointestinal; gastroprotectant; gauge; gdv; general; glaucoma; globe; gloves; glucocorticosteroids; glucose; glycol; goal; good; granulation; greater; hand; head; healing; healthy; heart; helpful; hemoglobin; hemolysis; hemolytic; hemophilia; hemorrhage; heparin; hepatic; hernia; high; higher; history; hospital; hours; hub; human; hyperkalemia; hypernatremia; hyperthermia; hyphema; hypoadrenocorticism; hypocalcemia; hypoglycemia; hypotension; hypoventilation; hypovolemic; hypoxemia; hypoxia; iatrogenic; illness; immediate; immune; impaired; important; inability; inch; incision; increase; induced; induction; infection; inflammation; infusion; ingested; ingestion; ingredient; inhalation; inhibit; initial; injuries; injury; insert; insufficiency; insulin; intercostal; intermediate; intermittent; interstitial; intervention; intoxication; intracranial; intraocular; intravascular; intravenous; intravenous catheter; intravenous fluid; introduction; intubation; irritation; ischemia; jugular; kg iv; kg po; kg sq; known; lacerations; lack; lactated; large; laryngeal; lateral; lavage; layer; lead; left; length; lens; lesions; lethargy; levels; lidocaine; life; likely; limb; limited; lipase; local; location; long; longer; loss; losses; lower; lung; maintenance; major; majority; male; management; mannitol; marrow; mass; massive; material; measures; mechanical; mechanism; medical; medications; medicine; membranes; meq; metabolic; methemoglobinemia; method; mild; milk; minimal; minimum; minutes; moderate; moist; monitor; monitoring; months; morphine; motion; motor; mouth; mucosa; mucous; multiple; muscle; nasal; necessary; neck; necrosis; needle; negative; neoplasia; nerve; neurologic; nonsteroidal; normal; note; noxious; nsaids; number; nutrition; object; obstruction; occurs; ocular; ointment; oncotic; ongoing; onset; open; opioids; oral; organ; orogastric; osmotic; output; owner; oximetry; oxygen; oxygenation; packed; pain; palpable; palpate; pancreatic; pancreatitis; paralysis; parenteral; partial; particular; patient; patient discomfort; pattern; paw; pcv; penetrating; penis; perforation; perform; perfusion; pericardial; period; peripheral; peritoneal; peritonitis; pet; phase; phenobarbital; phosphate; physical; physiologic; place; placement; plasma; platelet; pleural; pneumonia; pneumothorax; poison; polyuria; poor; position; positive; possible; potassium; potential; prepuce; prerenal; presence; present; presentation; pressure; primary; problem; procedure; process; products; profile; prognosis; progressive; prolapse; prolonged; propranolol; prostaglandin; prostatic; protein; proximal; pulmonary; pulse; pupils; puppies; push; pyometra; pyothorax; q12h; q24h; q8h; qrs; quality; radiation; radiographs; range; rapid; rare; rate; rbcs; reaction; receptor; recipient; recovery; rectal; recumbency; recurrence; red; refill; refractory; release; removal; renal; repair; repeat; reported; requirements; resection; respiratory; response; result; resuscitation; retention; retinal; return; rib; right; rigid; ringer; risk; roll; routine; rubber; rule; rupture; saline; salivation; samples; scrotal; scrub; secondary; section; secure; sedation; segment; seizures; sensitive; sepsis; septic; serum; severe; severe cases; severity; shock; short; significant; similar; simple; sinus; site; size; skin; slow; small; smoke; sodium; soft; solution; sounds; source; space; species; specific; spectrum; spinal; splint; stabilization; stabilized; start; state; status; sterile; stimulation; stomach; stroke; stylette; subcutaneous; subsequent; substances; successful; superficial; supplemental; supplementation; support; supportive; supraventricular; surface; surgery; surgical; suture; swelling; symptomatic; syndrome; synthetic; syringe; systemic; systems; table; tachyarrhythmias; tachycardia; tape; techniques; temperature; temporary; term; tests; therapeutic; therapy; thermal; thoracic; thoracocentesis; thoracostomy; thorax; thorough; thrombocytopenia; thromboembolism; time; tissue; topical; total; toxicity; toxin; tracheostomy; tract; transfusion; trauma; traumatic; treatment; treatment treatment; tremors; tube; tubing; tubular; tumor; type; ulcer; ulceration; ultrasound; underlying; units; unknown; upper; urethral; urinary; urinary catheter; urine; useful; uterine; uterus; vaginal; variety; vascular; ventilation; ventricular; vertebral; vessel; veterinarian; veterinary; viii; visible; vitamin; volume; volvulus; vomiting; von; wall; warm; water; weakness; weeks; weight; white; willebrand; wire; work; worsen; wound; young; zinc; âµg
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33. cord-029332-yn603pvb
    • author: None
    • title: Full Issue PDF
    • date: 2020-07-15
    • words: 11336
    • flesch: 34
    • summary: To recognize cardiovascular complications among COVID-19 patients. We are also learning that acute kidney injury is quite prevalent and highly associated with mortality in COVID-19 patients (6).
    • keywords: ace2; acute; acute respiratory; admission; almitrine; amiodarone; analysis; angiography; approach; ards; arrhythmias; arterial; associated; association; autonomic; available; best; block; blood; brugada; cardiac; cardiology; cardiomyopathy; cardiovascular; care; case; cell; characteristics; chest; children; china; clinical; coagulopathy; complications; concern; conduction; coronary; coronavirus; coronavirus disease; course; cov-2; covid-19; covid-19 disease; covid-19 pandemic; covid-19 patients; cytokine; data; days; diagnosis; differences; differential; disease; distress; dysfunction; early; ecg; elevation; embolism; emergency; endothelial; events; evidence; factors; failure; fever; figure; guidance; guidelines; health; heart; high; history; home; hospital; ill; incidence; infected; infection; inflammation; inflammatory; initial; injury; intensive; intervention; involvement; italy; jacc; laboratory; later; left; levels; like; low; lvad; management; markers; mechanical; medical; mild; mortality; myocardial; myocarditis; need; negative; new; normal; novel; outbreak; oxygen; pandemic; past; patients; pattern; percutaneous; pneumonia; positive; possible; present; presentation; pressure; prevention; primary; prior; prone; pulmonary; reports; research; respiratory; respiratory syndrome; response; retrospective; right; risk; room; sars; segment; setting; severe; severe acute; sex; significant; sinus; stemi; storm; study; support; symptoms; syndrome; system; table; tachycardia; takotsubo; therapy; thromboembolic; thrombosis; time; treatment; type; use; values; venous; ventilation; ventricular; viral; wuhan
    • versions: original; plain text
34. cord-029547-9ei1ram3
    • author: Li, Jingwei
    • title: The epidemiology and therapeutic options for the COVID-19
    • date: 2020-05-28
    • words: 7859
    • flesch: 39
    • summary: Then, the quantity of COVID-19 patients increased rapidly after Chinese New Year. According to the data collected in January 2020, the incubation stage of COVID-19 patients ranges between 2 and 14 days, and its average is about 5 days (95% credible interval: 4.2-6.0) when implementing the best-fit lognormal distribution.
    • keywords: ace2; acid; acute; aged; antibody; antiviral; arbidol; associated; asymptomatic; basic; binding; cases; cells; characteristics; china; chinese; chloroquine; clinical; combination; control; coronavirus; coronavirus disease; cov-2; covid-19; covid-19 patients; critical; data; days; diagnosis; disease; drugs; effect; epidemiological; epidemiology; evidence; features; fusion; group; high; higher; host; human; immunity; immunogenicity; important; inactivated; infected; infection; inhibitors; interval; lopinavir; low; medical; medicines; membrane; mers; model; mortality; ncov; necessary; novel; novel coronavirus; nucleic; number; outbreak; patients; pcr; penetration; people; period; pneumonia; positive; potential; prevention; protein; rate; receptor; remdesivir; replication; research; respiratory; ritonavir; rna; safety; sars; sensitivity; sequence; severe; specific; studies; study; symptoms; syndrome; therapeutic; therapy; time; transmission; treatment; trial; typical; vaccine; viruses; world; wuhan
    • versions: original; plain text
35. cord-031188-btrc3k4c
    • author: Shrestha, Sunil
    • title: Clinical Pharmacy Education and Practice in Nepal: A Glimpse into Present Challenges and Potential Solutions
    • date: 2020-08-14
    • words: 3522
    • flesch: 38
    • summary: Adv Med Educ Pract DOI: 10.2147/amep.s257351 sha: doc_id: 31188 cord_uid: btrc3k4c This commentary article highlights the challenges in providing clinical pharmacy education in Nepal and suggests a few ways forward. International collaborations in terms of faculty and student exchanges, preceptor training, and accreditation by international organizations such as Accreditation Council for Pharmacy Education (ACPE), establishment of need-based curriculum, incorporating clinical pharmacy department under the organizational structure of hospitals, etc., may be the right approaches to improve the current status of clinical pharmacy education in the country.
    • keywords: assessment; authors; cape; care; challenges; clinical; clinical pharmacy; community; countries; country; curriculum; drug; education; experiential; government; graduates; health; healthcare; hospitals; important; international; ipe; job; learning; management; ministry; nepal; npc; number; oriented; outcomes; patient; pharmaceutical; pharmacists; pharmacy; pharmacy education; pharmacy services; population; practice; preceptors; private; professionals; related; services; settings; skills; students; training; world
    • versions: original; plain text
36. cord-034340-3ksfpaf7
    • author: None
    • title: Proceedings of the 26th European Paediatric Rheumatology Congress: part 2: Virtual. 23 - 26 September 2020
    • date: 2020-10-28
    • words: 35133
    • flesch: 46
    • summary: Results: Of the 35 metabolites measured, 23 were significantly lower in JIA patients before the Etanercept treatment compared to the healthy control group. Urine metabolite ratios reflecting CYP21 and 11β-HSD2 enzymatic activity indicate that these two enzyme activities were lower in JIA patients.
    • keywords: aaa; abdominal; abnormal; acid; acr; activation; active; activities; activity; acute; adalimumab; addition; administration; adults; adverse; affected; age; aged; agents; ahai; aim; alpha; anakinra; analysis; ankles; anti; antibodies; antibody; artery; arthralgia; arthritis; articular; assessment; associated; association; autoimmune; autoinflammatory; available; average; better; bilateral; biologic; biopsy; biosimilar; blood; bone; boys; canakinumab; capillary; care; cases; cause; cell; characteristics; childhood; children; chronic; classification; clinical; cohort; collected; common; comparable; comparisons; complaints; complete; complicated; concentrations; conclusion; condition; confirmed; controls; correlation; corticosteroids; count; course; criteria; crp; cyclophosphamide; cyp; damage; data; days; decreased; demographic; development; diagnosis; differences; different; differential; diphtheria; disclosure; disease; disease activity; disease onset; disorders; dose; drug; duration; early; edema; effectiveness; effects; efficacy; elevated; erythema; esr; etn; evaluation; events; evidence; examination; experience; facial; factors; failure; family; fatigue; fcal; features; female; fever; findings; fit; flares; fluid; follow; following; fop; form; frequency; frequent; function; gastrointestinal; general; genetic; girls; gol; good; group; growth; healthy; high; higher; hip; history; hla; hlh; hospital; hsp; idiopathic; idiopathic arthritis; il-1; ilar; impact; important; improved; improvement; inactive; increased; index; infection; inflamed; inflammation; inflammatory; inhibitors; initial; initiation; intensity; interest; interstitial; intravenous; introduction; involvement; iqr; isolated; ivig; jadas; january; jdm; jia; jia patients; joint; juvenile; kawasaki; kidney; knee; knowledge; known; laboratory; lack; left; lesions; levels; life; likely; limb; line; literature; liver; long; loss; lower; lung; lupus; main; majority; manifestations; markers; marrow; mas; mean; measles; median; medical; medication; metabolites; methods; methotrexate; mild; monitoring; months; mri; mtx; multiple; muscle; musculoskeletal; mutation; n=1; negative; neurological; neutrophils; new; non; normal; normative; nsaids; number; objectives; old; oligoarticular; ongoing; onset; oral; outcome; overall; overlap; pain; parameters; parents; parotitis; pathogenesis; patients; pediatric; people; period; persistent; phase; phenotype; physical; physicians; plasma; polyarthritis; population; positive; positivity; possible; presence; present; presentation; prevalence; primary; prior; procedure; process; prognosis; progression; protein; psle; pts; pulmonary; questionnaire; range; rare; rash; rate; reactive; records; recurrent; red; relapse; remission; renal; reported; reports; resolution; response; results; retrospective; review; rheumatic; rheumatologist; rheumatology; right; risk; role; safety; samples; scores; second; secondary; serum; severe; significant; signs; single; sjia; sjögren; skin; sle; specific; spectrum; status; steroids; stroke; studies; study; survey; swelling; symptoms; syndrome; synovial; systemic; table; term; test; therapeutic; therapy; thyroid; time; tissue; titer; tnf; toc; total; treatment; trough; type; ultrasound; unit; untreated; use; uveitis; vaccination; values; vasculitis; vitamin; vzv; weeks; work; years; young
    • versions: original; plain text
37. cord-253295-82ydczid
    • author: Funkhouser, William K.
    • title: Pathology: the clinical description of human disease
    • date: 2020-07-24
    • words: 8869
    • flesch: 30
    • summary: The Pathologist is that physician or clinical scientist who specializes in the art and science of medical risk estimation and disease diagnosis, using observations at the clinical, gross, body fluid, light microscopic, immunophenotypic, ultrastructural, cytogenetic, and molecular levels. As the human genome is deciphered, and as the complex interactions of cellular biochemistry are refined, risk of disease in unaffected individuals will be calculable, disease diagnosis will be increasingly accurate and prognostic, and molecular subsets of morphologically defined disease entities will be used to guide customized therapy for individual patients.
    • keywords: abnormalities; abundance; accuracy; accurate; acid; anatomy; antibodies; antigen; approaches; aristotle; assays; bacteria; bce; benefit; binding; biology; blood; carcinoma; cause; cell; cellular; century; changes; chemical; chemistry; circa; clear; clinical; clinical disease; community; concepts; correlate; criteria; critical; current; data; deficiency; demonstration; description; detection; development; diagnosis; differences; different; differential; disease; dna; dyes; emphysema; etiologic; etiology; examination; example; features; fever; findings; fluid; follow; function; galen; genetic; genome; greek; gross; h&e; high; history; hla; human; hybridization; immunohistochemistry; improved; individuals; initial; instance; laboratories; laboratory; light; likely; lineage; liver; lung; malignant; medical; method; modern; molecular; molecules; morphologic; mutations; natural; neoplasms; new; non; normal; nucleic; observations; organ; outcome; particular; pathogenesis; pathologist; pathology; patient; physicians; physiology; portion; possible; prediction; primary; prior; prognosis; proteins; puerperal; radiographic; recognition; response; risk; rna; role; scientific; screening; sections; self; sequence; sequencing; set; signs; similar; single; small; specific; stains; structure; study; symptoms; technologies; technology; theory; therapy; thought; tissue; treatment; tumors; unaffected; understanding; uses; variables; variation; work; workup
    • versions: original; plain text
38. cord-255139-hswef5ky
    • author: Khan, Safdar A.
    • title: Differential Diagnosis of Common Acute Toxicologic Versus Nontoxicologic Illness
    • date: 2018-11-30
    • words: 861
    • flesch: 25
    • summary: Where necessary, with each rule-out, along with major clinical abnormality, a brief description of other clinical signs is also provided. Major clinical abnormalities are listed, along with common toxicologic rule outs and nontoxicologic rule outs.
    • keywords: abnormalities; acute; analysis; animal; blood; cause; clinical; common; complete; drugs; history; ill; nontoxicologic; pet; poisoning; presentation; recent; rule; signs; time; toxicology; veterinary
    • versions: original; plain text
39. cord-255140-3dwqqgv1
    • author: Christian, Michael D.
    • title: Biowarfare and Bioterrorism
    • date: 2013-07-04
    • words: 9453
    • flesch: 38
    • summary: The US Centers for Disease Control and Prevention (CDC) has identified and categorized a list of potential bioterrorism agents ( Table 1 ). 7, 19, 24, 35 The CDC list of potential bioterrorism agents (see Table 1 ) includes several toxins.
    • keywords: acute; addition; aerosol; aerosolized; agents; anthracis; anthrax; area; attack; available; bacillus; bacterial; biological; bioterrorism; bioterrorism agents; bioterrorism event; bioweapons; botulinum; box; burkholderia; care; cases; category; cause; cdc; cell; centers; chest; clinical; clinicians; clostridium; clothing; common; concern; contact; control; critical; cultures; cutaneous; days; decontamination; development; diagnosis; disease; effective; epidemic; epidemiology; event; exposure; factors; features; fever; food; form; gram; health; hemorrhagic; hours; human; illness; incident; infected; infection; ingestion; inhalation; insects; isolation; laboratory; large; level; likely; management; mass; medical; microbiological; natural; negative; nonspecific; occurring; organisms; past; patients; pestis; plague; pneumonic; potential; precautions; presentation; presents; primary; public; release; respiratory; response; ricin; risk; role; shock; significant; similar; skin; smallpox; soil; specific; spores; states; symptoms; syndrome; system; systemic; table; thoracic; time; toxin; transmission; tularemia; use; vhf; viral; virus; water
    • versions: original; plain text
40. cord-255746-ir73lpi8
    • author: Sirimaturos, Michael
    • title: Clinical Outcomes Following Tocilizumab Administration in Mechanically Ventilated Coronavirus Disease 2019 Patients
    • date: 2020-10-01
    • words: 4106
    • flesch: 32
    • summary: While several reports on tocilizumab treatment in COVID-19 patients now exist, data pertaining specifically to tocilizumab use in a large cohort of critically ill patients on invasive ventilation is lacking (11, 12) . This retrospective review of COVID-19 patients managed within the Houston Methodist Hospital System from March 24, 2020, to May 4, 2020, used data from electronic medical records and the institution's clinical surveillance program.
    • keywords: administration; algorithm; analysis; case; characteristics; clinical; cohort; coronavirus; covid-19; crp; crs; cytokine; data; days; digital; disease; dose; events; factors; failure; hospital; houston; il-6; ill; improvement; inflammatory; invasive; management; markers; mean; mechanical; model; mortality; onset; outcomes; pao; patients; peep; post; rale; rates; release; remdesivir; reports; respiratory; retrospective; severe; status; study; syndrome; therapies; time; tocilizumab; treatment; use; ventilation
    • versions: original; plain text
41. cord-258029-gyvg7ffa
    • author: Moolasart, Visal
    • title: Favipiravir-based regimen for coronavirus disease 2019 pneumonia for a 47-day-old male newborn
    • date: 2020-10-15
    • words: 1519
    • flesch: 41
    • summary: Novel coronavirus (2019-nCoV) situation reports Epidemiological characteristics and prevention and control measures of corona virus disease 2019 in children Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model Coronavirus disease (COVID-19) and neonate: what neonatologist need to know Clinical characteristics of children with coronavirus disease 2019 in Hubei, China A review of SARS-CoV-2 and the ongoing clinical trials Thailand ministry of public health. A 47-day-old, asymptomatic male newborn of coronavirus disease 2019 infected mother tested positive for coronavirus disease 2019 by reverse transcription polymerase chain reaction.
    • keywords: admission; bid; chest; china; clinical; coronavirus; cov-2; covid-19; day; days; disease; dose; drug; favipiravir; health; hydroxychloroquine; newborn; novel; old; patients; pneumonia; radiography; regimen; respiratory; sars; term; thailand; treatment
    • versions: original; plain text
42. cord-258049-l55mx4lp
    • author: Mansbach, Jonathan M.
    • title: Hospital course and discharge criteria for children hospitalized with bronchiolitis
    • date: 2015-01-28
    • words: 3703
    • flesch: 40
    • summary: Although the inability to include these children in the analysis may be seen as a limitation, this practice variability underscores the need for more data about discharging hospitalized children with bronchiolitis. Of the total, 1702 (88%) met clinical improvement criteria, with 4% worsening (3% required intensive care).
    • keywords: admission; age; apnea; average; bronchiolitis; care; children; clinical; clinical improvement; clinicians; course; criteria; current; daily; data; days; difficulty; discharge; distress; factors; hospital; hospitalized; icu; illness; improvement; infants; inpatient; los; months; multicenter; oxygen; pediatric; prospective; rao2; rate; recovery; respiratory; retractions; saturation; severe; site; study; threshold; time; variability; ward; worsening; years
    • versions: original; plain text
43. cord-258281-gxwk8jq9
    • author: Wenling, Yao
    • title: Pregnancy and COVID-19: management and challenges
    • date: 2020-08-31
    • words: 5024
    • flesch: 39
    • summary: Considering that SARS-CoV-2, SARS-CoV, and MERS-CoV are all β-coronaviruses, and their genomes, pathogenesis and clinical symptoms have certain similarities, this article draws lessons from previous studies on SARS-CoV and MERS-CoV infecting pregnant women to predict the impact of SARS-CoV-2 on pregnant women and fetuses and make some suggestions. In the same hospital, another newborn had confirmed COVID-19 infection 17 days after birth and a history of close contact with two confirmed cases 55 , the infant's mother and the maternity matron.
    • keywords: ace2; acute; alveolar; birth; brazil; cases; cells; cesarean; changes; characteristics; china; clinical; coronavirus; cough; cov-2; covid-19; days; deaths; delivery; disease; distress; east; evidence; features; february; fetal; fever; functional; higher; hospital; hypoxia; immune; infants; infection; intrauterine; lung; maternal; mers; middle; myalgia; n=2; neonates; newborns; novel; outcomes; patients; placental; pneumonia; pregnancy; pregnant; pregnant women; preterm; rate; receptor; report; respiratory; review; sars; severe; small; study; symptoms; syndrome; throat; transmission; trimester; vertical; women; wuhan
    • versions: original; plain text
44. cord-260993-udajtsmm
    • author: Youssef, Mohanad
    • title: COVID‐19 and Liver Dysfunction: a systematic review and meta‐analysis of retrospective studies
    • date: 2020-05-23
    • words: 2059
    • flesch: 45
    • summary: On comparison between the two groups, severe patients were nearly three times more likely to receive steroids (OR = 3.17, 95%CI = 3.02-4.97, p <0.001) and immunoglobulins (OR = 2.75, 95%CI = 1.09-6.94, p = 0.032). A total of 20 eligible retrospective cohort studies, including 3428 positively confirmed COVID-19 patients, were enrolled in the current meta-analysis.
    • keywords: analysis; article; bias; cases; characteristics; china; clinical; copyright; coronavirus; covid-19; disease; dysfunction; figure; heterogeneity; higher; infection; injury; levels; liver; meta; outcomes; patients; publication; quality; results; retrospective; rights; sample; sars; severe; significant; size; studies; study; treatment; wuhan
    • versions: original; plain text
45. cord-262784-r9gq2oan
    • author: Tian, Suochen
    • title: Clinical Characteristics and Reasons for Differences in Duration From Symptom Onset to Release From Quarantine Among Patients With COVID-19 in Liaocheng, China
    • date: 2020-05-12
    • words: 3755
    • flesch: 45
    • summary: Patients in the >20-day group were older, and the time from onset to admission was longer, suggesting that although there was no specific antiviral drug for COVID-19, systematic supportive treatment administered after admission could improve outcomes, even among patients with mild and moderate disease. Front Med (Lausanne) DOI: 10.3389/fmed.2020.00210 sha: doc_id: 262784 cord_uid: r9gq2oan Objective: This study aimed to identify additional characteristics and features of coronavirus disease (COVID-19) by assessing the clinical courses among COVID-19 patients in a region outside Hubei province.
    • keywords: acid; admission; average; blood; cases; characteristics; china; chinese; clinical; coronavirus; count; covid-19; day; days; differences; disease; duration; group; lymphocyte; medicine; mild; moderate; novel; nucleic; number; onset; outcomes; patients; pneumonia; province; quarantine; release; respiratory; results; study; symptom; test; time; treatment; white; wuhan; ≤20
    • versions: original; plain text
46. cord-262843-i0cy7467
    • author: Suzumoto, Masaki
    • title: A scoring system for management of acute pharyngo-tonsillitis in adults
    • date: 2008-09-05
    • words: 3342
    • flesch: 42
    • summary: Numbers of total white blood cells and levels of C-reactive protein showed a significant positive correlation with clinical scores (p < 0.001) and were also higher in cases with S. pyogenes. Correlation between clinical scores and numbers of WBC or levels of CRP were assessed Pearson regression analysis.
    • keywords: acute; adults; antibiotics; antimicrobial; bacteria; cases; clinical; crp; diagnosis; disease; group; illness; infections; isolates; levels; management; mild; moderate; numbers; patients; pharyngitis; pharyngo; pyogenes; scores; scoring; severe; severities; severity; sore; streptococci; study; system; test; throat; tonsillar; tonsillitis; total; use; virus; viruses; wbc
    • versions: original; plain text
47. cord-263936-8yud5o6c
    • author: Wang, Gary X.
    • title: Opportunities for Radiology Trainee Education Amid the COVID-19 Pandemic: Lessons from an Academic Breast Imaging Program
    • date: 2020-10-03
    • words: 2814
    • flesch: 29
    • summary: While reduced clinical imaging volume and mandates to maintain physical distancing presented new challenges to traditional medical education during this period, new opportunities developed to support our division in providing high-quality training for residents and fellows. While all senior residents had already fulfilled ACGME breast imaging requirements prior to implementation of the virtual curriculum, the schedule for the next academic year (2020-2021) was constructed to ensure remaining junior residents fulfilled their required 12 weeks of clinical breast imaging rotations prior to graduation.
    • keywords: attending; breast; care; cases; challenges; clinical; conferences; continued; core; covid-19; daily; day; diagnostic; division; educational; fellows; imaging; learning; mammography; measures; medical; mitigation; new; oncology; opportunities; pandemic; patients; peak; period; procedures; processes; radiology; residents; review; risk; screening; site; support; trainees; training; ultrasound; use; virtual; volumes; work
    • versions: original; plain text
48. cord-266469-n484zqq1
    • author: King, Michael J.
    • title: Lung base CT findings in COVID-19 adult patients presenting with acute abdominal complaints: case series from a major New York City health system
    • date: 2020-07-04
    • words: 4135
    • flesch: 39
    • summary: key: cord-266469-n484zqq1 authors: King, Michael J.; Lewis, Sara; El Homsi, Maria; Hernandez Meza, Gabriela; Bernheim, Adam; Jacobi, Adam; Chung, Michael; Taouli, Bachir title: Lung base CT findings in COVID-19 adult patients presenting with acute abdominal complaints: case series from a major New York City health system date: 2020-07-04 journal: To describe demographic, clinical, and lung base CT findings in COVID-19 patients presenting with abdominal complaints.
    • keywords: abdomen; abdominal; ace2; acute; admission; age; base; cases; chest; china; clinical; complaints; conditions; coronavirus; cov-2; covid-19; ct findings; data; days; demographic; difference; discharged; disease; features; findings; following; frequent; gastrointestinal; health; hospitalisation; hospitalised; imaging; infection; iqr; laboratory; lung; lung base; median; medical; multifocal; n =; opacities; outcomes; pain; patients; peripheral; population; positive; range; reports; respiratory; review; sars; study; symptoms; system; underlying; values; viral; years
    • versions: original; plain text
49. cord-266730-mio282vy
    • author: Li, Long‐quan
    • title: COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis
    • date: 2020-03-23
    • words: 1311
    • flesch: 46
    • summary: key: cord-266730-mio282vy authors: Li, Long‐quan; Huang, Tian; Wang, Yong‐qing; Wang, Zheng‐ping; Liang, Yuan; Huang, Tao‐bi; Zhang, Hui‐yun; Sun, Weiming; Wang, Yuping title: COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis date: 2020-03-23 journal: J Med Virol DOI: 10.1002/jmv.25757 sha: doc_id: 266730 cord_uid: mio282vy The aim of this study was to analyze the clinical data, discharge rate, and fatality rate of COVID‐19 patients for clinical help. The clinical data of COVID‐19 patients from December 2019 to February 2020 were retrieved from four databases.
    • keywords: analysis; bias; cases; characteristics; china; clinical; coronavirus; covid‐19; data; discharge; disease; fatality; features; meta; model; novel; patients; pneumonia; rate; results; studies; study; wang
    • versions: original; plain text
50. cord-267608-0odu8lus
    • author: Chen, Daohong
    • title: Innovative highlights of clinical drug trial design
    • date: 2020-06-03
    • words: 4167
    • flesch: 23
    • summary: Clinical trial plays an indispensable role in evaluating efficacy and safety of therapeutic agents prior to marketing for human use, and has been constantly co-evolving along with the dynamic interactions between cutting-edge scientific discoveries and regulatory policy updating [2, 3] . In this light, the article herein highlights an array of outstanding developments in the perspective of drug trial design, being corroborated by notable successes in the clinical settings.
    • keywords: accelerated; adaptive; analysis; approach; approval; basket; bio; biosimilar; cancer; cell; certain; clinical; compound; contemporary; design; development; disease; dose; dosing; drug; efficacious; efficacy; efficiency; fda; field; fusion; generic; human; imatinib; indication; inhibitor; innovative; interim; investigation; kinase; larotrectinib; lung; medicine; new; non; novel; nsclc; orphan; orr; patients; phase; policy; prior; processing; products; rare; rcts; regulatory; safety; scientific; seamless; spectrum; stage; studies; study; subjects; targeted; therapeutic; traditional; treat; treatment; trial; trk; tumor; types
    • versions: original; plain text
51. cord-272727-a5ngjuyz
    • author: Bertsimas, D.
    • title: From predictions to prescriptions: A data-drivenresponse to COVID-19
    • date: 2020-06-29
    • words: 3599
    • flesch: 47
    • summary: We have 206 therefore initiated a multi-institution collaboration to collect 207 electronic medical records from COVID-19 patients and de-208 velop clinical risk calculators. Once the 223 burden on hot spots has ebbed, hospitals began to aggregate 224 rich data on COVID-19 patients.
    • keywords: america; appendix; available; average; calculators; care; clinical; cohort; coronavirus; count; covid-19; data; database; decisions; demand; disease; disparities; distancing; elevated; erent; europe; features; figure; gatherings; healthcare; hospitals; impact; infection; information; insights; lab; level; major; management; mass; model; mortality; new; number; pandemic; patients; policies; prevalence; rate; reports; results; risk; severe; shortages; social; spread; state; study; support; symptoms; system; triage; use; values; ventilators
    • versions: original; plain text
52. cord-273973-3uxg97tu
    • author: Guenette, Alexis
    • title: Infectious Complications Following Solid Organ Transplantation
    • date: 2019-01-31
    • words: 5625
    • flesch: 22
    • summary: Italian Study Group of Fungal Infections in Thoracic Organ Transplant Recipients Aspergillus infection in single and double lung transplant recipients Opportunistic mycelial fungal infections in organ transplant recipients: emerging importance of non-Aspergillus mycelial fungi CNS infections in solid organ transplant recipients Infections of the central nervous system in transplant recipients Central nervous system syndromes in solid organ transplant recipients Infectious complications more than 1 year after liver transplantation: a 3-decade nationwide experience The importance of late infections for the long-term outcome after liver transplantation Biliary complications following liver transplantation Etiology and management of hepatic artery thrombosis after adult liver transplantation Infections in solid-organ transplant recipients Hepatitis G virus in patients with cryptogenic liver disease undergoing liver transplantation Life-threatening infection in transplant recipients Fungal infections in transplant and oncology patients Epidemiology and risk factors for infection after living donor liver transplantation Infections after living donor liver transplantation in children Infectious complications in living-donor liver transplant recipients: a 9-year single-center experience Abnormal liver tests after liver transplantation Diagnostic yields in solid organ transplant recipients admitted with diarrhea Severe diarrhea in renal transplant patients: results of the DIDACT study Incidence and risk factors for diarrhea following kidney transplantation and association with graft loss and mortality Gastrointestinal complications in liver transplant recipients: MITOS study Gastrointestinal complications in renal transplant recipients: MITOS study Gastrointestinal complications in renal transplant patients: a large, single-center experience Diarrhoea following renal transplantation Diarrhea in organ transplant recipients Clinical practice. Changing pattern of microbial etiologies Infectious complications after kidney transplantation: current epidemiology and associated risk factors Pneumonia Infection In Organ Transplant Recipients Pneumonia in solid organ recipients: spectrum of pathogens in 217 episodes Microbiologic features and outcome of pneumonia in transplanted patients Infectious pulmonary complications in lung transplant recipients A standardized protocol for the treatment of severe pneumonia in kidney transplant recipients Pneumonia in solid organ transplant recipients: a prospective multicenter study The diagnosis of pneumonia in renal transplant recipients using invasive and noninvasive procedures Pulmonary complications in cardiac transplant recipients Nocardiosis following solid organ transplantation: a single-centre experience RNA respiratory viruses in solid organ transplantation Respiratory viral infections in immunocompetent and immunocompromised persons Clinical implications of respiratory virus infections in solid organ transplant recipients: a prospective study Respiratory viral infections in transplant recipients Respiratory viruses and chronic rejection in lung transplant recipients
    • keywords: antibiotic; aspergillus; asymptomatic; bacterial; blood; bloodstream; broad; candida; care; cause; clinical; clostridium; cmv; common; community; complications; coverage; data; diagnosis; diarrhea; difficile; disease; donor; early; empiric; epidemiology; factors; failure; fig; fungal; graft; gram; hepatic; higher; immunosuppression; incidence; infections; invasive; kidney; likely; liver; liver transplant; local; lung; lung transplant; management; microbiological; mortality; negative; nosocomial; organ; organ transplant; organisms; outcome; overall; pathogens; patients; pcr; period; pneumonia; positive; previous; prophylaxis; range; recipients; regards; renal; resistant; respiratory; risk; sepsis; single; solid; solid organ; sot; sot recipients; species; study; therapy; tract; transplant; transplant patients; transplant recipients; transplantation; treatment; urinary; uti; viral; virus
    • versions: original; plain text
53. cord-274283-ukhgs6z1
    • author: Goel, Sunny
    • title: Clinical Characteristics and In-Hospital Mortality for COVID-19 Across The Globe
    • date: 2020-07-18
    • words: 1999
    • flesch: 31
    • summary: Washington Risk of QT interval prolongation associated with use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease Characteristics of hospitalized adults with COVID-19 in an integrated health care system in California Epidemiological characteristics of coronavirus disease 2019 (COVID-19) patients in IRAN: a single center study Initial experiences from patients with COVID-19 on ventilatory support in Denmark Prevalence and characteristics of gastrointestinal symptoms in patients with SARS-CoV-2 Infection in the United States: a multicenter cohort study Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York city area High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation Clinical impact of renin-angiotensin system inhibitors on in-hospital mortality of patients with hypertension hospitalized for COVID-19 Clinical features and treatment of COVID-19 patients in northeast Chongqing Suppressed T cellmediated immunity in patients with COVID-19: a clinical retrospective study in Wuhan Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): a multi-center study in Wenzhou city Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore Analysis of clinical characteristics and laboratory findings of 95 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a retrospective analysis Risk factors for disease severity, unimprovement, and mortality in COVID-19 patients in Wuhan. Apart from cardiovascular diseases, respiratory conditions [lung disease, COPD, or asthma], CKD, and immunosuppression/HIV were also prevalent among COVID-19 patients.
    • keywords: america; article; asia; baseline; care; case; characteristics; china; clinical; coronavirus; covid-19; disease; europe; features; globe; higher; hospital; hospital mortality; laboratory; mortality; novel; outcomes; patients; region; retrospective; sars; severe; significant; studies; study; wuhan
    • versions: original; plain text
54. cord-274481-k1dp1ilv
    • author: Falavigna, Maicon
    • title: Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology
    • date: 2020
    • words: 6979
    • flesch: 33
    • summary: COVID-19 Treatment Guidelines Zhejiang Da Xue Xue Bao Yi Xue Ban Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: openlabel, randomized, controlled trial Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19 Observational study of hydroxychloroquine in hospitalized patients with Covid-19 Risk of QT interval prolongation associated with use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19) Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: a pilot observational study Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: a retrospective analysis of 1061 cases in Marseille, France A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19. Zhejiang Da Xue Xue Bao Yi Xue Ban Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open-label, randomized, controlled trial Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Risk of QT interval prolongation associated with use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19) Observational study of hydroxychloroquine in hospitalized patients with Covid-19 Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: a retrospective analysis of 1061 cases in Marseille, France Safety of hydroxychloroquine, alone and in combination with azithromycin, in light of rapid wide-spread use for COVID-19: a multinational, network cohort and self-controlled case series study Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: a pilot observational study No evidence of rapid antiviral clearance or clinical benefit with the combination of hydroxychloroquine and azithromycin in patients with severe COVID-19 infection The QT interval in patients with SARS-CoV-2 infection treated with hydroxychloroquine/ azithromycin Early description of coronavirus 2019 disease in kidney transplant recipients in New York Inpatient use of mobile continuous telemetry for COVID-19 patients treated with hydroxychloroquine and azithromycin.
    • keywords: -we; 95%ci; adverse; agents; analysis; anti; antibiotics; appropriate; assessment; available; azithromycin; bacterial; benefit; case; china; clinical; cohort; combination; comments; confidence; coronavirus; corticosteroids; covid-19; covid-19 patients; daily; data; days; development; disease; document; dose; drug; effect; estimate; et al; events; evidence; grade; group; guidelines; hcq; health; heparin; high; hydroxychloroquine; infection; influenza; interval; interventions; level; lopinavir; low; mesh; moderate; mortality; negativation; non; observational; oseltamivir; outcomes; panel; patients; potential; protocols; quality; randomized; rapid; recommendations; respiratory; results; retrospective; risk; ritonavir; routine; sars; series; severe; significant; studies; study; summary; syndrome; systematic; therapies; therapy; tocilizumab; treatment; trials; use; viral; weak
    • versions: original; plain text
55. cord-274802-7ioiwsd8
    • author: Varghese, Praveen Mathews
    • title: Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies
    • date: 2020-08-19
    • words: 19710
    • flesch: 31
    • summary: Unlike SARS, COVID-19 patients had the highest viral load near presentation, which could account for the fast-spreading nature of this epidemic. In a study involving COVID-19 patients in Hong Kong recorded high viral load on presentation with the onset of symptoms and also when the symptoms are mild (83) .
    • keywords: ace2; activation; activity; acute; acute respiratory; addition; adults; adverse; alveolar; analysis; antibodies; antibody; antiviral; ards; associated; association; asymptomatic; autoimmune; binding; blood; btk; c5a; cancer; candidate; care; case; cd4; cd8; cells; centre; chadox1; changes; characteristics; children; china; clinical; coagulation; cohort; combination; complement; complex; complications; control; convalescent; coronavirus; coronavirus disease; cov-2; covid-19; covid-19 infection; covid-19 patients; cytokines; damage; day; days; death; development; differences; different; disease; distress; dose; drug; dysfunction; early; effects; efficacy; elevated; endothelial; enhanced; entry; evidence; expression; factor; failure; fda; features; findings; form; fusion; healthy; heart; high; higher; hospital; host; human; hydroxychloroquine; icu; igg; il-6; ill; immune; immunity; immunogenicity; increase; individuals; infected; infection; inflammation; inflammatory; inhibitor; injury; innate; interferon; ivig; kawasaki; key; kidney; kinase; label; leads; levels; like; likely; liver; load; lopinavir; lower; lung; mac; macrophages; manifestations; mechanical; mechanism; membrane; memory; mers; mice; microangiopathy; mild; moderate; mortality; mrna; multi; multisystem; ncov; neutralizing; neutrophils; new; non; novel; observational; older; onset; open; organ; outcomes; pathogenesis; pathways; patients; period; person; phase; plasma; pneumonia; population; positive; possible; post; pregnancy; pregnant; present; production; protease; protective; protein; pulmonary; randomized; rate; rbd; reactive; receptor; recovery; release; remdesivir; replication; reported; reports; respiratory; respiratory syndrome; response; results; retrospective; review; rhesus; risk; ritonavir; rna; role; safety; samples; sars; sars coronavirus; series; serum; severe; severe acute; severe covid-19; severity; significant; similar; single; small; specific; spike; standard; state; storm; studies; study; surface; symptoms; syndrome; syndrome coronavirus; system; systematic; t cells; therapeutic; therapy; thrombin; thrombotic; time; titres; tmprss2; tnf; transcriptome; transmission; treatment; trial; type; tyrosine; use; vaccination; vaccine; vascular; ventilation; viral; virions; volunteers; women; wuhan; years
    • versions: original; plain text
56. cord-276255-0ofsa40u
    • author: Cheong, Mark Wing Loong
    • title: ‘To be or not to be in the ward’: The Impact of Covid‐19 on the Role of Hospital‐Based Clinical Pharmacists ‐ A Qualitative Study
    • date: 2020-08-12
    • words: 3677
    • flesch: 49
    • summary: Three main themes were developed: ‘Reassignment and other changes in clinical pharmacist roles’, ‘Adapting clinical pharmacy services to COVID‐19’, and ‘The need for clinical pharmacists in the ward’. The coding and subsequent analysis of the findings of this study led to the development of 3 main themes: 'Reassignment and other changes in clinical pharmacist roles', 'Adapting clinical pharmacy services to COVID-19', and 'The need for clinical pharmacists in the ward'.
    • keywords: ability; article; care; clinical; clinical pharmacists; copyright; covid-19; essential; health; health care; hospital; impact; malaysia; medication; pandemic; participants; patients; pharmaceutical; pharmaceutical care; pharmacists; pharmacy; pharmacy services; ppe; practice; reserved; rights; role; services; study; supply; support; team; use; ward; workers
    • versions: original; plain text
57. cord-276495-q22jnkn2
    • author: Belizário, José Ernesto
    • title: Trained innate immunity, COVID-19 therapeutic dilemma, and fake science
    • date: 2020-07-06
    • words: 2771
    • flesch: 37
    • summary: The objective is to demonstrate whether immunization with BCG vaccines produced using different strains and titers of the bacillus Calmette-Guérin-the vaccine against tuberculosis-can protect these professionals against SARS-CoV-2 infection (3). Clinical trials BRACE (www.clinicaltrialgov, number NCT04327206) and BCG-corona (www.clinicaltrial.gov, number NCT04328 441) are employing large cohorts of health professionals in the Netherlands, Denmark, Germany, England, France, Tanzania, Uganda, Colombia, and Uruguay (3).
    • keywords: arrhythmia; bcg; brazil; cells; chloroquine; clinical; clones; countries; covid-19; disease; effects; evidence; genes; group; health; history; human; hydroxychloroquine; immunity; immunological; infection; innate; knowledge; lymphocytes; medical; memory; monocytes; mortality; non; number; pathogen; patients; proteins; response; results; sars; scientific; second; specific; studies; study; therapeutic; treatment; trials; types; vaccination; vaccine; ventricular
    • versions: original; plain text
58. cord-276740-4wwo9tho
    • author: Overholser, James C.
    • title: Roll Out the Red Carpet: The 3rd Annual Awards for the Most Valuable Contributions to Psychotherapy
    • date: 2020-05-20
    • words: 5332
    • flesch: 38
    • summary: There is a risk that the field of psychotherapy will deteriorate if the people who write the books, chapters, and research articles are faculty members who no longer provide clinical services themselves. Many articles were excluded because their subjects were limited to analogue samples, such as healthy college students, anonymous online surveys, or mTurk recruitment.
    • keywords: approach; article; assessment; authors; award; best; case; category; clients; clinical; clinical practice; cognitive; colleagues; communication; comprehensive; contributions; depression; different; disorder; experience; exposure; field; health; highlights; ideas; important; individuals; integration; interoceptive; journal; limited; maltreatment; march; measures; mental; need; nominees; overholser; papers; patients; personal; personality; practice; professional; project; prospective; psychiatric; psychological; psychologists; psychology; psychotherapy; recent; research; retrospective; review; role; samples; scholarly; science; sessions; single; strategies; studies; study; technology; treatment; use; useful; valuable; value; winner; work; year
    • versions: original; plain text
59. cord-277528-t0tglg0a
    • author: Tay, Yi Xiang
    • title: Clinical placements for undergraduate diagnostic radiography students amidst the COVID-19 pandemic in Singapore: Preparation, challenges and strategies for safe resumption
    • date: 2020-08-18
    • words: 3255
    • flesch: 42
    • summary: SIT prepared students by emphasising compliance to all risk measures, addressing concerns of risk transmission, meeting learning objectives, and reassessing infection control competencies. In tandem, SGH prepared an orientation program and used technology for open communication among faculty, clinical educators and students which included monitoring of well-being and rapid dissemination of updates.
    • keywords: areas; breaker; cases; circuit; clinical; compliance; concerns; control; covid-19; department; distancing; education; educators; experience; faculty; hcis; health; healthcare; high; infection; learning; measures; national; orientation; outcomes; pandemic; physical; placements; practice; radiography; radiology; ratio; resumption; risk; safe; sgh; singapore; sit; strategies; students; support; survey; technology; temperature; training; use; year
    • versions: original; plain text
60. cord-279255-v861kk0i
    • author: Dhama, Kuldeep
    • title: Coronavirus Disease 2019–COVID-19
    • date: 2020-06-24
    • words: 23944
    • flesch: 36
    • summary: Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein Animal models for SARS and MERS coronaviruses Recent advances in the vaccine development against Middle East respiratory syndromecoronavirus Virology: SARS virus infection of cats and ferrets A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in golden Syrian hamsters Animal models and vaccines for SARS-CoV infection Infection with MERS-CoV causes lethal pneumonia in the common marmoset Vaccines for the prevention against the threat of MERS-CoV Molecular basis of coronavirus virulence and vaccine development Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection Genetically engineering a susceptible mouse model for MERS-CoV-induced acute respiratory distress syndrome Prospects for a MERS-CoV spike vaccine A mouse model for MERS coronavirus-induced acute respiratory distress syndrome Replicative capacity of MERS coronavirus in livestock cell lines Entry of human coronavirus NL63 into the cell China's response to a novel coronavirus stands in stark contrast to the 2002 SARS outbreak response Novel coronavirus is putting the whole world on alert Early epidemiological analysis of the coronavirus disease 2019 outbreak based on crowdsourced data: a population-level observational study Estimation of the transmission risk of the 2019-nCoV and its implication for public health interventions The mental health of medical workers in Wuhan, China dealing with the 2019 novel coronavirus The progress of 2019 novel coronavirus (2019-nCoV) event in China Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study Response to the emerging novel coronavirus outbreak Potential for global spread of a novel coronavirus from China Novel coronavirus, poor quarantine, and the risk of pandemic Novel Coronavirus outbreak in Wuhan, China, 2020: intense surveillance is vital for preventing sustained transmission in new locations Risk for transportation of 2019 novel coronavirus disease from Wuhan to other cities in China Infections without borders: a new coronavirus in Wuhan, China An interactive web-based dashboard to track COVID-19 in real time Limiting spread of COVID-19 from cruise ships-lessons to be learnt from Japan Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records A case of 2019 novel coronavirus in a pregnant woman with preterm delivery Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study A pregnant woman with COVID-19 in Central America Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19). CEPI to fund three programmes to develop vaccines against the novel coronavirus, nCoV-2019 Moderna announces funding award from CEPI to accelerate development of messenger RNA (mRNA) vaccine against novel coronavirus Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms Treatment with interferon-␣2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics Potential antiviral therapeutics for 2019 novel coronavirus A novel coronavirus outbreak of global health concern Coronavirusesdrug discovery and therapeutic options Treatment with lopinavir/ritonavir or interferon-␤1b improves outcome of MERS-CoV infection in a nonhuman primate model of common Marmoset Treatment of Middle East respiratory syndrome with a combination of lopinavir-ritonavir and interferon-␤1b (MIRACLE trial): study protocol for a randomized controlled trial Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein Characterization of novel monoclonal antibodies against MERScoronavirus spike protein Crossneutralization of SARS coronavirus-specific antibodies against bat SARS-like coronaviruses New coronavirus threat galvanizes scientists Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody Cell-based antiviral screening against coronaviruses: developing virus-specific and broad-spectrum inhibitors Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection Potential interventions for novel coronavirus in China: a systemic review Human transbodies that interfere with the functions of Ebola virus VP35 protein in genome replication and transcription and innate immune antagonism Inhibitors of RAS might be a good choice for the therapy of COVID-19 pneumonia Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture
    • keywords: ace2; acid; activity; acute; advanced; agents; amino; analysis; animal; antibodies; antibody; antiviral; assessment; associated; asymptomatic; available; barrier; bat; bat sars; bats; betacoronavirus; binding; blood; broad; care; cases; cats; cause; cell; changes; characterization; chest; china; chinese; chloroquine; clinical; close; cluster; combination; common; contact; control; coronavirus; coronavirus disease; coronavirus infection; coronavirus outbreak; countries; cov infection; cov-2; covid-19; covid-19 coronavirus; covid-19 infection; covid-19 outbreak; covid-19 patients; covid-19 pneumonia; covs; critical; cross; cruise; current; data; days; designing; detection; developing; development; diagnosis; different; disease; dogs; domain; drugs; early; east; ebola; effective; efficacy; efficient; efforts; emergence; entry; epidemic; epitopes; evidence; evolution; experience; fecal; ferrets; fig; findings; food; fusion; future; genetic; genome; genomic; global; glycoprotein; health; high; higher; host; human; human coronavirus; human transmission; hydroxychloroquine; hygiene; ideal; identification; ill; immune; increase; individuals; infected; infection; inflammatory; inhibitors; initial; interaction; international; isolates; ivermectin; lack; later; level; like; live; load; lopinavir; lower; lung; mabs; major; management; manifestations; markets; measures; medicine; mers; mice; microbiology; middle; models; molecular; ncov; need; negative; neutralizing; new; novel; novel coronavirus; novel sars; nucleic; nucleocapsid; nucleotide; number; occurrence; oral; origin; outbreak; pandemic; pathogenesis; pathogens; patients; pcr; people; period; pigs; plasma; pneumonia; population; positive; possibility; possible; potential; practices; pregnant; present; prevention; previous; primary; protective; protein; public; range; rapid; rbd; real; recent; receptor; regions; remdesivir; replication; reports; research; reservoir; respiratory; respiratory syndrome; response; results; reviews; risk; ritonavir; rna; role; routes; samples; sars; sars coronavirus; sars outbreak; screening; sequence; severe; significant; similarity; single; small; species; specific; spectrum; spike; spillover; spread; stool; strains; strategies; strategy; structural; studies; study; substitutions; susceptible; swabs; symptoms; syndrome; syndrome coronavirus; system; target; test; therapeutic; therapy; threat; time; tract; transmission; treatment; trials; vaccine; veterinary; viral; viruses; vivo; wastewater; wet; wild; wildlife; workers; world; wuhan; years; zoonotic
    • versions: original; plain text
61. cord-279559-mob8dbcr
    • author: Coleman, Carl H.
    • title: Equitably Sharing the Benefits and Burdens of Research: Covid‐19 Raises the Stakes
    • date: 2020-05-14
    • words: 1378
    • flesch: 36
    • summary: The question of where Covid-19 clinical trials will be conducted is relevant to both the burdens and benefits of research. For example, in the United States, there is substantial evidence that African American and Hispanic and Latinx patients are underrepresented among clinical trial participants.
    • keywords: access; african; benefits; burdens; clinical; companies; covid-19; development; disparities; equity; health; homes; important; medical; needs; participants; products; questions; recruitment; research; treatments; trials; vaccines; world
    • versions: original; plain text
62. cord-280093-w71e0ex9
    • author: Jung, So-Young
    • title: Monitoring in clinical trials of complementary and alternative medicine
    • date: 2020-09-23
    • words: 2251
    • flesch: 38
    • summary: Integr Med Res DOI: 10.1016/j.imr.2020.100666 sha: doc_id: 280093 cord_uid: w71e0ex9 BACKGROUND: Clinical trial monitoring is an essential activity for quality assurance (QA) to ensure the protection of human rights and the reliability and transparency of the data collection process. key: cord-280093-w71e0ex9 authors: Jung, So-Young; Kang, Jung Won; Kim, Tae-Hun title: Monitoring in clinical trials of complementary and alternative medicine date: 2020-09-23 journal:
    • keywords: cam; clinical; clinical trials; conduct; consent; data; documents; gcp; human; ich; medical; monitoring; necessary; need; participants; process; protection; protocol; purpose; quality; relevant; research; rights; site; source; sponsor; study; trials; visit
    • versions: original; plain text
63. cord-280431-tuzdng4h
    • author: Alinier, Guillaume
    • title: 5 Basing a Nonclinician's Career upon Simulation The Personal Experience of a Physicist
    • date: 2008-12-31
    • words: 3509
    • flesch: 37
    • summary: This chapter concerns the breed of people who start by selecting a nonclinician path and eventually work in clinical simulation. There are many different opportunities and responsibilities in the domain of clinical simulation, and nonclinicians could occupy almost any one of them.
    • keywords: able; available; care; center; clinical; colleagues; communication; development; different; education; engineering; environment; equipment; experience; faculty; field; flight; health; health care; job; learning; manager; medical; need; new; opportunities; participants; patient; payers; people; range; reality; research; role; scenarios; simulation; simulation center; simulators; skills; students; teaching; technical; technology; today; training; university; useful; work
    • versions: original; plain text
64. cord-281391-0qkku2jd
    • author: Miller-Handley, Hilary
    • title: Treatment Options for COVID-19 in Patients with Reduced or Absent Kidney Function
    • date: 2020-09-17
    • words: 4721
    • flesch: 41
    • summary: Janssen Medical Information Face Sheet The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China Clinical Features of 69 Cases with Coronavirus Disease ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells FDA Approval Summary: Tocilizumab for Treatment of Chimeric Antigen Receptor T Cell-Induced Severe or Life-Threatening Cytokine Release Syndrome Effective treatment of severe COVID-19 patients with tocilizumab Tocilizumab therapy reduced intensive care unit admissions and/or mortality in COVID-19 patients ACTEMRA® (tocilizumab) injection, for intravenous or subcutaneous use JAK-inhibitors. Corticosteroids usage in COVID-19 was originally controversial, because some data in SARS patients found no difference between steroid usage and no steroid usage in clinical outcomes; although studies were small, and mostly non-randomized [40] .
    • keywords: activity; acute; antiviral; azithromycin; benefit; case; cell; china; chronic; clearance; clinical; control; convalescent; coronavirus; cov-2; covid-19; cytokine; data; disease; drug; early; hydroxychloroquine; idsa; improved; infection; influenza; inhibitors; jak; kidney; lopinavir; mers; mortality; multiple; ongoing; outcomes; pandemic; patients; plasma; pneumonia; prophylaxis; randomized; release; remdesivir; respiratory; risk; ritonavir; rna; sars; severe; studies; study; syndrome; therapy; tocilizumab; treatment; trials; usage; use; vaccine; viral
    • versions: original; plain text
65. cord-282131-wap7lo05
    • author: Chen, Haixia
    • title: Clinical and imaging features of COVID-19
    • date: 2020-04-27
    • words: 3386
    • flesch: 43
    • summary: [6] specifically formulated clinical diagnosis standards for patients in Hubei Province, and defined suspected cases with pneumonia imaging manifestations as clinical diagnostic cases, which reduced the risk of further spread. The central distribution of the lesion is different from the characteristic subpleural distribution of new coronavirus pneumonia.
    • keywords: acid; basis; cases; cells; central; changes; chest; china; clinical; common; consolidation; coronavirus; coronavirus disease; covid-19; detection; diagnosis; disease; early; examination; fig; glass; ground; imaging; infection; laboratory; lesions; lung; manifestations; mild; multiple; ncov; new; novel; nucleic; patients; pneumonia; pulmonary; respiratory; scheme; severe; shadow; stage; symptoms; tests; thickening; treatment; trial; type; version; viral; wuhan
    • versions: original; plain text
66. cord-282202-q2q4vies
    • author: Banerjee, Amitava
    • title: Clinical academic research in the time of Corona: A simulation study in England and a call for action
    • date: 2020-08-13
    • words: 4111
    • flesch: 41
    • summary: Dissemination: across UK and internationally to those considering COVID-19 clinical research. key: cord-282202-q2q4vies authors: Banerjee, Amitava; Katsoulis, Michail; Lai, Alvina G.; Pasea, Laura; Treibel, Thomas A.; Manisty, Charlotte; Denaxas, Spiros; Quarta, Giovanni; Hemingway, Harry; Cavalcante, João L.; Noursadeghi, Mahdad; Moon, James C. title: Clinical academic research in the time of Corona: A simulation study in England and a call for action date: 2020-08-13 journal: PLoS One DOI: 10.1371/journal.pone.0237298 sha: doc_id: 282202 cord_uid: q2q4vies OBJECTIVES:
    • keywords: academic; analysis; approaches; april; available; basic; capacity; care; cases; china; clinical; clinical academics; coronavirus; countries; covid-19; data; days; delivery; different; doctors; emergency; england; frontline; funding; global; hcw; health; healthcare; high; hospital; impact; infection; intensive; italy; key; learning; medical; mitigation; model; needs; new; nhs; nightingale; normal; number; pandemic; patients; population; rate; recommendations; relaxed; research; response; scenarios; science; simple; staff; statistics; strain; studies; study; system; time; web; weeks; workforce
    • versions: original; plain text
67. cord-282261-wcmc5mh6
    • author: Rhodus, Elizabeth K.
    • title: COVID-19 and geriatric clinical trials research
    • date: 2020-09-16
    • words: 2258
    • flesch: 31
    • summary: Further, older adults are substantially underrepresented in clinical trials research, and this situation may worsen this discrepancy. Attention to clinical trial development with special attention to need for inclusion of older adults and precautions is greatly needed to sustain current efforts, at minimum, and ideally, enhance recognition of the value of including older adults in clinical trial research.
    • keywords: adults; aging; authors; challenges; clinical; cognitive; community; conduct; covid-19; crisis; critical; current; design; disasters; disruption; effects; efficacy; efforts; engagement; future; geriatric; healthcare; imaging; impact; long; measures; need; older; ongoing; pandemic; participants; recruitment; research; researchers; safety; scientific; social; studies; study; support; trials
    • versions: original; plain text
68. cord-282298-8tcw3cll
    • author: Wang, Jie
    • title: Current Situation and Perspectives of Clinical Study in Integrative Medicine in China
    • date: 2012-02-21
    • words: 8025
    • flesch: 29
    • summary: Aiming at the hot issues and knotty problems confronted in clinical medicine, we could put forward scientific hypotheses in exploring the etiology and pathogenesis of the disease and seek for the effective therapeutic principles and classical prescriptions. With medical science transforming from traditional experience medicine into evidence-based medicine, fundamental changes have taken place in clinical medicine.
    • keywords: academician; achievements; acute; analysis; apl; application; arsenic; attention; bacteria; basis; blood; blood circulation; blood stasis; capsule; cardiovascular; cases; china; chinese; chinese medicine; chronic; circulation; classical; clinical; combination; complementary; compound; control; coronary; coronary heart; corresponding; curative; decoction; deficiency; development; diagnosis; differentiation; disease; dysfunction; effect; effective; efficacy; evaluation; evidence; expression; factors; fibrosis; formula; function; great; group; health; heart; heart disease; herbs; indications; injection; injury; integrative; integrative medicine; international; intervention; leukemia; level; liver; lung; mechanism; medical; medicine; method; mode; modern; mortality; myocardial; new; organ; patients; percutaneous; practice; prescriptions; prevention; progress; promyelocytic; purgation; rate; reperfusion; research; restenosis; science; severe; stasis; stasis syndrome; studies; study; syndrome; syndrome differentiation; system; tablets; tcm; technology; theory; therapeutic; therapy; toxin; traditional; treating; treatment; type; western; world; xsc; yin
    • versions: original; plain text
69. cord-283202-5fq1wxz8
    • author: Kent, Marc
    • title: The cat with neurological manifestations of systemic disease. Key conditions impacting on the CNS
    • date: 2009-05-31
    • words: 7334
    • flesch: 36
    • summary: Unfortunately, very few references provide detailed descriptions of large cohorts of affected cats. 18 Hematology in affected cats usually reveals a normocytic, normochromic, nonregenerative anemia, leukocytosis consisting of a neutrophilia, and lymphopenia.
    • keywords: acids; active; acute; affected; amlodipine; ammonia; animals; antibodies; antibody; blood; blood pressure; brain; cases; cats; central; cerebrospinal; chain; changes; chronic; clindamycin; clinical; clinical signs; cns; common; concentrations; congenital; consequence; coronavirus; csf; damage; definitive; detection; diagnosis; disease; dogs; effect; encephalopathy; enteric; experimental; failure; fcov; feline; feline infectious; findings; fip; fipv; fluid; function; gondii; healthy; hepatic; high; hypertension; identification; igg; igm; immune; increase; infected; infection; lactulose; liver; management; metabolism; mutation; nervous; neurological; non; normal; oral; organ; pathogenesis; pcr; peritonitis; portosystemic; pressure; prevalence; process; production; protein; renal; response; result; risk; secondary; serum; severe; shunts; signs; similar; systemic; systolic; therapy; tissue; titers; toxoplasma; toxoplasmosis; treatment; underlying; virus; weeks
    • versions: original; plain text
70. cord-283545-vu8lt3w6
    • author: Brabb, Thea
    • title: Infectious Diseases
    • date: 2011-12-16
    • words: 28881
    • flesch: 42
    • summary: Otitis media, conjunctivitis, and an inflamed prostate gland are signs that have been associated with Pseudomonas in other reports of guinea pig infection (Fox, 2002) . key: cord-283545-vu8lt3w6 authors: Brabb, Thea; Newsome, Denise; Burich, Andrew; Hanes, Martha title: Infectious Diseases date: 2011-12-16 journal: The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents DOI: 10.1016/b978-0-12-380920-9.00023-7 sha: doc_id: 283545 cord_uid: vu8lt3w6 Although guinea pigs are sensitive and susceptible to the development of lesions from a wide range of viruses, bacteria, protozoa, and parasites, only a small number of organisms cause natural infection and only a portion of that group cause clinical disease.
    • keywords: actinobacillus; acute; addition; adenovirus; administration; affected; agar; agent; anaerobic; analysis; animals; anorexia; antibiotic; antibodies; appearance; areas; assay; associated; asymptomatic; aureus; background; bacteria; baker; barthold; bedding; blood; boot; bordetella; bovine; brain; breeding; bronchiseptica; c. caviae; carrier; cases; causative; cause; caviae; cecum; cells; cervical; chronic; citrobacter; clinical; clinical signs; clostridium; coli; colonies; colony; coman et; common; conjunctiva; conjunctivitis; contact; contaminated; contamination; contents; control; corynebacterium; culture; cuniculi; cunningham; cysts; cytomegalovirus; days; death; dermatitis; dermatophytes; detection; development; diagnosis; diarrhea; difficile; direct; discharge; disease; distinct; dna; domestic; dorrestein; early; elisa; encephalitozoon; enteritis; entry; environment; epithelial; epizootic; epizootiology; equi; et al; etiology; experimental; family; fatal; fauquet; fecal; feces; flora; food; fox; free; fungi; ganaway; genome; genus; gondii; gpcmv; gram; greenwood; group; guinea pigs; hair; harkness; herpes; herpesvirus; high; histopathology; hoosier; host; hours; human; hyperplasia; identification; iii; ileum; immune; immunity; important; induced; infected; infected animals; infection; infestation; infiltration; inflammation; inflammatory; ingestion; inoculation; intestinal; intracellular; isolation; kidney; kim; kim et; laboratory; laboratory animals; laboratory guinea; large; lcmv; leptospira; lesions; leukemia; lice; like; likely; liver; loss; lung; lutz; lymph; lymphadenitis; lymphocytic; mammals; manifestations; means; media; members; mentagrophytes; mice; microscopy; microsporidia; mites; model; moniliformis; monitoring; months; mortality; mucosal; multocida; nasal; natural; necropsy; necrosis; necrotizing; negative; new; nodes; nodules; non; normal; numerous; oral; order; organisms; organs; otitis; outbreak; parainfluenza; parainfluenza virus; parasites; particles; pathogenesis; pathogenic; pathology; pcr; percy; perfringens; period; pet; pet guinea; piliforme; pneumonia; pododermatitis; positive; possible; post; potential; present; prevalence; prevention; primary; prior; protozoa; pseudomonas; pseudotuberculosis; pvm; rabbits; rare; rats; recovered; reovirus; report; research; resistance; respiratory; result; rigby; rodentium; rodents; salmonella; samples; schonfelder et; secondary; sendai; septicemia; sequence; sequencing; serological; severe; short; significant; signs; similar; simmons et; single; skin; small; smears; songer; species; specific; spleen; spontaneous; spore; spp; spread; stages; strain; streptobacillus; streptococcus; studies; study; subsp; successful; susceptible; sv5; system; therapy; time; tissue; tract; transmission; treatment; trichophyton; trixacarus; type; tyzzer; ulcerative; urine; van; vanbronswijk; variety; viral; virus; viruses; wagner; wagner et; wall; water; weeks; white et; wild; wohlgroth et; wrairi; year; yersinia; young; young guinea; zooepidemicus; zoonotic
    • versions: original; plain text
71. cord-283779-mudwcypl
    • author: Lauretani, Fulvio
    • title: Assessment and treatment of older individuals with COVID-19 multi-system disease: clinical and ethical implications
    • date: 2020-05-11
    • words: 9739
    • flesch: 35
    • summary: As a consequence of multimorbidity, polypharmacy defined as the number of drugs reported at hospital admission and the potential drug-drug interactions require a careful evaluation in older COVID-19 patients. These principles have been often ignored, especially in older COVID-19 patients.
    • keywords: activation; activity; acute; admission; adults; adverse; age; anti; antiviral; ards; assessment; associated; azithromycin; balance; body; cardiac; care; case; cell; china; chronic; clinical; common; coronavirus; corticosteroids; cov-2; covid-19; covid-19 infection; critical; damage; data; day; days; diagnosis; different; dimer; disease; distress; drug; early; effects; endothelial; energy; evaluation; events; exercise; failure; fever; following; functional; heparin; high; higher; home; hospital; hospitalization; host; hydroxychloroquine; icu; il-6; immune; important; increased; individuals; infected; infection; inflammatory; influenza; inhibitors; intestinal; italy; levels; lower; lung; malnutrition; management; mechanical; mortality; msec; muscle; needs; non; novel; number; nutritional; obesity; older; older patients; outcomes; oxygen; patients; people; persons; phase; physical; pneumonia; possible; potential; presence; protein; pulmonary; qtc; randomized; rate; recent; recovery; remdesivir; renal; respiratory; response; review; risk; ritonavir; sars; score; serum; severe; severity; specific; status; studies; study; subjects; support; swab; symptoms; syndrome; system; systematic; table; therapy; thrombotic; treatment; trials; use; ventilation; viral; virus; weight
    • versions: original; plain text
72. cord-287607-d3k26aar
    • author: Emamaullee, Juliet
    • title: Rapid Adaptation of a Surgical Research Unit to Conduct Clinical Trials during the Coronavirus-19 Pandemic.
    • date: 2020-06-29
    • words: 3273
    • flesch: 30
    • summary: Ongoing ‘Stay at Home’ orders and institutional policies mandating ‘Work from Home’ for non-essential employees, which includes most research personnel, have impacted the ability to implement and conduct clinical studies. By centralizing the clinical trials process within the department and under the guidance of an experienced Chief and seasoned research team, the capacity for clinical studies has increased substantially while maintaining a stable number of study personnel (Figure 1) .
    • keywords: adjustments; amendments; approach; clinical; collection; conduct; contact; coordinators; covid-19; data; department; division; enrollment; financial; home; hospital; implementation; institutional; irb; march; need; new; non; number; ongoing; pandemic; participants; patient; personnel; potential; protocol; related; remote; research; safety; specific; sponsor; staff; studies; study; surgical; team; time; timely; trials; unit; viability; work
    • versions: original; plain text
73. cord-289520-i6pv90s9
    • author: Harris, Carlyn
    • title: An evidence-based framework for priority clinical research questions for COVID-19
    • date: 2020-03-31
    • words: 4709
    • flesch: 42
    • summary: Three bibliographic databases were searched to identify clinical studies published on SARS-CoV and MERS-CoV in the outbreak setting. Overall, clinical characterisation studies commonly found bilateral involvement with ground glass opacity, though a range of presentations were reported [8] [9] [10] 15] .
    • keywords: acute; available; care; case; characterisation; china; clinical; cohort; control; coronavirus; covid-19; data; death; designs; diagnostic; disease; early; epidemic; factors; health; illness; infected; infection; information; international; isaric; key; laboratory; mers; ncov; novel; organization; outbreak; patients; pneumonia; presentation; prevention; protocol; public; questions; report; research; respiratory; review; risk; samples; sars; setting; severe; shedding; specimens; standardised; studies; study; syndrome; systematic; theme; transmission; treatment; trials; understanding; viral; workers; world; wuhan
    • versions: original; plain text
74. cord-293151-g3758oes
    • author: Nemzek, Jean A.
    • title: Biology and Diseases of Dogs
    • date: 2015-07-10
    • words: 30311
    • flesch: 42
    • summary: Dogs have well developed olfactory glands, vision, and auditory and tactile senses that allow them to gain environmental cues and information from other dogs and humans (Field and Jackson, 2006; Joint Working Group on Refinement, 2004) . For example, from 3 to 8 weeks of age, puppies are most capable of learning about how to interact with other dogs.
    • keywords: abdominal; abnormalities; access; acral; acute; addition; administration; adult; affected; age; aggressive; anesthesia; angarano; animal; anorexia; antibiotic; appropriate; area; aspiration; associated; association; available; avgeris; bacterial; beagles; behavior; benign; best; biomedical; biopsy; bitch; bite; blood; body; bone; bph; breeding; breeds; bronchiseptica; burn; campylobacter; cancer; canine; canis; cardiovascular; care; cases; catheter; cats; cause; cavity; cell; cell tumors; chapter; chemotherapy; choice; chronic; classification; clean; clinical; clinical signs; closure; colony; common; comparison; complete; complications; composition; condition; congenital; contact; contaminated; contamination; control; corneal; cough; culture; cysts; damage; data; days; death; debridement; decrease; deep; deeper; definitive; delivery; development; diagnosis; diarrhea; diets; differential; differential diagnosis; direct; discharge; disease; disorder; dogs; drugs; early; edema; effective; effects; eggs; elbow; energy; enlarged; enterohepatic; environment; epizootiology; estrogen; estrus; et al; etiology; evaluation; examination; experimental; exposure; extensive; external; eye; facilities; factors; failure; fat; features; female; ferguson; fetal; fever; findings; flea; fluid; food; formula; free; gastric; gastrointestinal; general; gland; glandular; golden; good; grade; gram; granuloma; group; growth; guide; guidelines; hair; healing; health; heat; helicobacter; hemorrhagic; high; hormone; host; housing; human; hygromas; hyperplasia; hypothyroidism; identification; illness; important; increase; individuals; indwelling; infected; infection; infestation; inflammation; inflammatory; information; initial; injury; insemination; intake; interdigital; intestinal; isolation; jejuni; johnson; jps; known; laboratory; laboratory animal; large; leptospirosis; lesions; levels; lick; life; likely; local; location; long; loss; lung; lymphoma; macewen; majority; male; malignant; mammary; management; masses; mast; material; medicine; metabolic; mild; models; months; movement; multiple; muscle; national; necessary; necrosis; needle; negative; neoplasia; nodes; normal; number; nutrient; nutrition; obesity; onset; oral; order; organisms; origin; pain; palpation; panciera; paralysis; parturition; parvovirus; pathogenesis; pathologic; pcr; peterson; pneumonia; point; poor; population; ports; positive; possible; potential; pregnancy; presence; present; pressure; prevention; primary; problem; production; proestrus; progesterone; proper; prostate; prostatic; protein; pulmonary; puppies; pups; purpose; radiation; random; rapid; rate; recurrence; red; regulations; removal; reported; reproductive; requirements; research; respiratory; response; result; review; risk; secondary; self; semen; sensitivity; sepsis; serovars; serum; setting; severe; severity; significant; signs; similar; simple; site; size; skin; small; source; species; specific; sperm; spontaneous; spp; stage; status; streptococcus; studies; study; subclinical; subcutaneous; superficial; surface; surgery; surgical; swaim; swelling; syndrome; systemic; systems; term; testing; therapy; thermal; thickness; tick; time; tissue; topical; total; tract; transmissible; transmission; trauma; treatment; trevor; tsh; tumors; type; ulceration; ulcers; underlying; use; uterine; uterus; vaccinated; vaginal; vascular; vasculitis; veterinary; virus; volume; vomiting; vulva; waldron; water; weeks; weight; welfare; wound; years; young; zooepidemicus
    • versions: original; plain text
75. cord-296692-t5p09le8
    • author: Elgin, T.G.
    • title: The changing landscape of SARS-CoV-2: Implications for the maternal-infant dyad
    • date: 2020-09-07
    • words: 5331
    • flesch: 42
    • summary: The development of international registries to enable risk profiling of COVID-19 positive pregnant mothers and/or their offspring may facilitate the development of enhanced mitigation strategies, medical treatments and effective vaccinations. The authors concluded increased risk of preterm birth in COVID-19 positive pregnant mothers.
    • keywords: ace2; age; analysis; asymptomatic; birth; care; case; china; clinical; coronavirus; cov-2; covid-19; current; days; delivery; development; disease; distress; early; elevated; evidence; fetal; fetus; fever; findings; gestation; health; high; illness; immune; impact; infant; infected; infection; italy; likely; maternal; mild; mothers; negative; neonatal; neonates; non; novel; outcomes; pandemic; patients; perinatal; phenotype; pneumonia; positive; potential; pregnancy; pregnant; preterm; rapid; report; respiratory; review; risk; sars; section; series; severe; specific; spread; strategies; studies; study; swabs; symptoms; syndrome; system; testing; transmission; treatment; vertical; viral; weeks; women; workers; wuhan
    • versions: original; plain text
76. cord-298899-lkrmg5qr
    • author: Xie, Yewei
    • title: Epidemiologic, clinical, and laboratory findings of the COVID-19 in the current pandemic: systematic review and meta-analysis
    • date: 2020-08-31
    • words: 6251
    • flesch: 50
    • summary: Download today's data on geographic distribution of COVID-19 cases worldwide Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: retrospective case series Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: a retrospective cohort study Ethnicity and COVID-19: an urgent public health research priority COVID-19 sex-disaggregated data tracker-Sex, gender and COVID-19 Clinical features and outcomes of 98 patients hospitalized with SARS-CoV-2 infection in Daegu, South Korea: a brief descriptive study Early epidemiological and clinical manifestations of COVID-19 in Japan Clinical, radiological and therapeutic characteristics of patients with COVID-19 in Saudi Arabia Clinical course and potential predicting factors of pneumonia of adult patients with coronavirus disease 2019 (COVID-19): a retrospective observational analysis of 193 confirmed cases in Thailand Characteristics, risk factors and outcomes among the first consecutive 1096 patients diagnosed with COVID-19 in Kuwait Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO clinical characterization protocol: prospective observational cohort study Clinical characteristics of patients hospitalized with COVID-19 in Spain: results from the SEMI-COVID-19 network Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: an observational retrospective study COVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis Clinical characteristics of coronavirus disease (COVID-19) early findings from a teaching hospital in Pavia Clinical and epidemiological characteristics of patients diagnosed with COVID-19 in a tertiary care center in Mexico CITY: a prospective cohort study Early experience with COVID-19 patients at academic hospital in southwestern United States Clinical characteristics and morbidity associated with coronavirus disease 2019 in a series of patients in metropolitan Detroit Clinical characteristics of Covid-19 in New York city Epidemiological and clinical characteristics of the early phase of the COVID-19 epidemic in Brazil Acute-onset smell and taste disorders in the context of COVID-19: a pilot multicentre polymerase chain reaction based case-control study Utility of hyposmia and hypogeusia for the diagnosis of COVID-19 Selfreported olfactory and taste disorders in patients with severe acute respiratory coronavirus 2 infection: a cross-sectional study COVID-19 anosmia reporting tool: initial findings Features of anosmia in COVID-19 Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China Smell dysfunction: a biomarker for COVID-19. In the US for example, the reasons that turned hospitals into infection hotspots included the overload of COVID-19 patients and inappropriate management against the pandemic in hospitals [29] .
    • keywords: acute; additional; analysis; asymptomatic; cases; cfr; characteristics; china; clinical; closed; common; community; conditions; control; coronavirus; countries; country; course; cov-2; covid-19; data; days; death; disease; early; epidemic; epidemiological; exposure; factors; features; file; findings; health; higher; hospital; household; hsm; icu; incubation; infected; infection; italy; july; korea; male; march; medical; meta; mortality; multiple; ncov; novel; novel coronavirus; number; outbreak; outcomes; pandemic; patients; pcr; people; period; pneumonia; population; potential; prevention; proportion; rate; records; research; results; retrospective; review; risk; sars; severe; south; spread; stage; states; studies; study; super; symptoms; time; transmission; united; workers; wuhan; years
    • versions: original; plain text
77. cord-299082-s8bm40vy
    • author: Wang, Yueying
    • title: Cardiac arrhythmias in patients with COVID‐19
    • date: 2020-07-26
    • words: 3724
    • flesch: 31
    • summary: An example of reversible electrical storm Incessant monomorphic ventricular tachycardia during febrile illness in a patient with Brugada syndrome: fatal electrical storm Fhf2 gene deletion causes temperature-sensitive cardiac conduction failure Fever increases the risk for cardiac arrest in the Brugada syndrome Hyperthermia influences the effects of sodium channel blocking drugs in human-induced pluripotent stem cell-derived cardiomyocytes Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic Antihypertensive treatment with ACEI/ARB of patients with COVID-19 complicated by hypertension Angiotensin II and angiotensin 1-7: which is their role in atrial fibrillation? CaMKII as a target for arrhythmia suppression Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology COVID-19-related severe hypercoagulability in patients admitted to intensive care unit for acute respiratory failure Cardiac and arrhythmic complications in patients with COVID-19 Cardiac arrhythmias in acute coronary syndromes: position paper from the joint EHRA, ACCA, and EAPCI task force Calcium-calmodulin dependent protein kinase II (CaMKII): a main signal responsible for early reperfusion arrhythmias Acute regional left atrial ischemia causes acceleration of atrial drivers during atrial fibrillation Mechanisms of atrial tachyarrhythmias associated with coronary artery occlusion in a chronic canine model Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro Electrophysiologic studies on the risks and potential mechanism underlying the proarrhythmic nature of azithromycin Azithromycin causes a novel proarrhythmic syndrome Toxicity of macrolide antibiotics on isolated heart mitochondria: a justification for their cardiotoxic adverse effect Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan Multilead QT screening is necessary for QT measurement: implications for management of patients in the COVID-19 era Inpatient use of mobile continuous telemetry for COVID-19 patients treated with hydroxychloroquine and azithromycin Expert recommendations for clinical management of myocardial injury associated with coronavirus disease Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies COVID-19) This is followed by a discussion on the underlying mechanisms, with proposals of preventative and therapeutic strategies for treating cardiac arrhythmias in COVID-19 patients.
    • keywords: acute; addition; ang; angiotensin; arrhythmias; associated; atrial; azithromycin; block; cardiac; cardiomyocytes; cardiovascular; cases; channel; characteristics; clinical; common; complications; coronavirus; covid-19; critical; current; disease; ecg; effects; fibrillation; guan; hcq; heart; high; hua; hydroxychloroquine; incidence; infection; injury; interval; mechanisms; myocardial; novel; outcomes; patients; pneumonia; potential; previous; prolongation; qtc; respiratory; risk; role; sars; severe; studies; study; syndrome; tachycardia; treatment; underlying; ventricular; wuhan; xin; xue; zhi; zhong
    • versions: original; plain text
78. cord-300325-f3eomugb
    • author: Ferguson, Nadia C.
    • title: Clinical Pharmacists: An Invaluable Part of the Coronavirus Disease 2019 Frontline Response
    • date: 2020-10-15
    • words: 2475
    • flesch: 25
    • summary: key: cord-300325-f3eomugb authors: Ferguson, Nadia C.; Quinn, Nicholas J.; Khalique, Saira; Sinnett, Mark; Eisen, Lewis; Goriacko, Pavel title: Clinical Pharmacists: While literature reports on the experiences of many frontline staff, there is a scarcity of reports on the role of clinical pharmacists during this crisis.
    • keywords: acute; addition; administration; agents; areas; available; care; cases; clinical; clinical pharmacists; clinicians; coronavirus; covid-19; crisis; critical; daily; data; direct; disease; drug; effective; epicenter; fentanyl; fig; frontline; health; healthcare; ill; increase; investigational; management; march; medical; medication; medicine; new; pandemic; patients; pharmacists; rapid; respiratory; response; role; safety; sedation; severe; shortages; supply; system; use; work; york
    • versions: original; plain text
79. cord-304479-uxp1kg86
    • author: Goodarzi, Pedram
    • title: Coronavirus disease 2019 (COVID-19): Immunological approaches and emerging pharmacologic treatments
    • date: 2020-08-08
    • words: 8115
    • flesch: 35
    • summary: Furthermore, there are some open clinical trials for the therapeutic assessment of methylprednisolone on COVID-19 patients [57] . [58] , shows that at least six different published studies on the effect of corticosteroids on COVID-19 patients.
    • keywords: ace2; activity; acute; agent; analysis; angiotensin; antibodies; antibody; antiviral; approaches; arbidol; associated; azithromycin; blood; cases; cells; china; clinical; colleagues; control; convalescent; coronavirus; corticosteroids; cov-2; covid-19; covid-19 patients; current; cytokine; days; dengue; disease; drugs; early; ebola; effective; effects; efficacy; favipiravir; figure; group; hcq; high; hucmscs; human; hydroxychloroquine; il-6; immune; improved; infected; infection; inflammatory; influenza; inhibits; ivermectin; load; lopinavir; mabs; mers; mesenchymal; mild; monoclonal; mortality; ncov; neutralizing; new; non; novel; nuclear; pandemic; patients; placebo; plasma; pneumonia; possible; potential; protein; randomized; rate; recent; receptor; remdesivir; replication; report; respiratory; results; review; ribavirin; risk; ritonavir; rna; safety; sars; severe; severe covid-19; severity; soluble; stem; storm; studies; study; symptoms; syndrome; systematic; table; therapeutic; therapy; treatment; trials; viral; viruses
    • versions: original; plain text
80. cord-306351-ka6asw3m
    • author: Alsuliman, Tamim
    • title: A review of potential treatments to date in COVID-19 patients according to the stage of the disease
    • date: 2020-05-30
    • words: 6067
    • flesch: 42
    • summary: key: cord-306351-ka6asw3m authors: Alsuliman, Tamim; Alasadi, Lugien; Alkharat, Banan; Srour, Micha; Alrstom, Ali title: A review of potential treatments to date in COVID-19 patients according to the stage of the disease date: 2020-05-30 journal: Curr Res Transl Med DOI: 10.1016/j.retram.2020.05.004 sha: doc_id: 306351 cord_uid: ka6asw3m Abstract Introduction and motivation: Since the end of 2019, the COVID-19 pandemic has affected millions of people worldwide. Since human safety data for Remdesivir are available from several clinical trials that tested Remdesivir's efficacy against Ebola virus, several clinical trials are already being held in the United States and China to investigate its efficacy treating COVID-19 patients [7, 26, 32] .
    • keywords: ace2; activity; adults; angiotensin; antiviral; bcg; cases; cells; china; chinese; clinical; cohort; combination; confirmed; control; coronavirus; countries; cov-2; covid-19; cytokine; data; day; days; different; disease; dose; drug; early; effective; efficacy; group; guidance; guidelines; hcq; human; hydroxychloroquine; iii; il-6; illness; immune; improvement; infection; inflammation; inflammatory; inhibitor; ivermectin; key; lopinavir; lpv; lung; management; mortality; negative; new; novel; ongoing; patients; phase; pneumonia; potential; pulmonary; randomized; rapid; receptor; remdesivir; replication; respiratory; results; review; ritonavir; safety; sars; severe; severity; stage; states; studies; study; therapeutic; therapies; therapy; tocilizumab; treatment; trials; use; vaccine; viral; vitro
    • versions: original; plain text
81. cord-308284-r546ypur
    • author: Simpson, Shmona
    • title: Navigating facilitated regulatory pathways during a disease X pandemic
    • date: 2020-10-23
    • words: 7033
    • flesch: 33
    • summary: To mitigate this, national and regional regulatory agencies generally should engage with their global regulatory counterparts and WHO Prequalification in a collaborative approach to product assessment and oversight under emergency circumstances, especially when novel outbreak etiologies and novel therapeutic and prophylactic modalities are being proffered. For products manufactured in, or used in, countries that cannot assure quality standards, WHO Prequalification is a system developed to help procurers of Prequalification eligible products determine if the products they are procuring meets international regulatory standards for product efficacy, safety and manufacturing quality.
    • keywords: accelerated; access; administration; agencies; agency; animal; application; approaches; approval; article; assessment; authorities; authorization; available; benefit; candidates; clinical; clinical trials; conditional; countermeasures; countries; data; designation; development; disease; drug; early; efficacy; ema; emergencies; emergency; epidemic; eul; european; example; facilitated; fda; food; health; health emergency; human; income; investigational; key; manufacturing; marketing; medical; medicines; model; national; need; new; novel; nras; outbreak; pathways; phase; post; potential; prequalification; process; product; program; public; public health; regulatory; review; risk; rule; safety; scientific; situations; specific; states; studies; support; therapy; time; trials; united; unmet; use; vaccine; world
    • versions: original; plain text
82. cord-308421-22rcptor
    • author: Perez-Gracia, Jose Luis
    • title: ESMO Clinical Research Observatory (ECRO): improving the efficiency of clinical research through rationalisation of bureaucracy
    • date: 2020-05-10
    • words: 3368
    • flesch: 21
    • summary: ECRO will aim to provide the views of ESMO on clinical research procedures based on the feedback from clinical investigators, under complete adherence to the Declaration of Helsinki, the GCP guidelines and any other applicable legal regulations, while at the same time showing profound respect for all the stakeholders involved in clinical research. ECRO will aim to provide the views of ESMO on clinical research procedures based on the feedback from clinical investigators, under complete adherence to the Declaration of Helsinki, the GCP guidelines and any other applicable legal regulations, while at the same time showing profound respect for all the stakeholders involved in clinical research.
    • keywords: adherence; administrative; analysis; burden; bureaucracy; cancer; care; clinical; clinical investigators; clinical research; complexity; current; declaration; development; ecro; esmo; events; experienced; gcp; guidelines; helsinki; informed; interference; investigators; legal; medical; non; number; patients; physicians; practice; procedures; protocols; recommendations; regulations; relevant; research; safety; stakeholders; study; teams; time; trials; years
    • versions: original; plain text
83. cord-309080-1r8t8yxv
    • author: Tay, Yi Xiang
    • title: The needs and concerns of clinical educators in radiography education in the face of COVID-19 pandemic
    • date: 2020-10-19
    • words: 2533
    • flesch: 31
    • summary: During clinical training, students are supported by clinical educators who are usually registered professionals who facilitate clinical education alongside clinical and J o u r n a l P r e -p r o o f academic colleagues 8 . key: cord-309080-1r8t8yxv authors: Tay, Yi Xiang; Cai, Sihui; Chow, Hwei Chuin; Lai, Christopher title: The needs and concerns of clinical educators in radiography education in the face of COVID-19 pandemic date: 2020-10-19 journal: J Med Imaging Radiat Sci DOI: 10.1016/j.jmir.2020.10.004 sha: doc_id: 309080 cord_uid: 1r8t8yxv nan It has been more than 8 months since Singapore reported its first COVID-19 case on January 23 rd , 2020 1 .
    • keywords: academic; challenges; clinical; clinical educators; community; covid-19; distancing; education; educators; encouragement; experience; face; generation; global; health; healthcare; impact; learning; measures; medical; needs; outbreak; pandemic; perspectives; placement; practice; professional; psychological; radiographers; radiography; risk; sars; singapore; students; support; teaching; training; ways; work
    • versions: original; plain text
84. cord-310027-846vp7ii
    • author: Ma, Lin-Lu
    • title: Coronavirus Disease 2019 Related Clinical Studies: A Cross-Sectional Analysis
    • date: 2020-09-02
    • words: 4252
    • flesch: 43
    • summary: We did an electronic search of COVID-19 related clinical studies registered between December 1, 2019 and February 21, 2020 (updated to May 28, 2020) from the ClinicalTrials.gov, and collected registration information, study details, recruitment status, characteristics of the subjects, and relevant information about the trial implementation process. Registration of COVID-19 related clinical studies is ongoing.
    • keywords: analysis; antibody; authors; characteristics; clinical; clinical studies; clinical trials; coronavirus; cov-2; covid-19; data; design; diagnosis; disease; drugs; effective; et al; guidelines; hcq; health; high; hydroxychloroquine; infected; infection; insufficient; interventional; lopinavir; ncov; new; novel; number; observational; open; patients; pneumonia; potential; prevention; quality; randomized; recruitment; registered; registration; research; researchers; respiratory; results; review; ritonavir; sample; sars; size; status; studies; study; test; time; treatment; trials; use
    • versions: original; plain text
85. cord-310150-j1mvr9r9
    • author: Wei, Wei
    • title: Identification of common and severe COVID-19: the value of CT texture analysis and correlation with clinical characteristics
    • date: 2020-07-01
    • words: 3113
    • flesch: 50
    • summary: This retrospective study was performed to analyze the correlations among CT texture features, clinical features, and clinical subtypes of COVID-19 and to explore the value of CT texture analysis in determining the severity of COVID-19. The prediction model based on CT text features achieved a sensitivity of 0.80 and a specificity of 0.95, which means that CT texture analysis can early accurately assess disease severity.
    • keywords: accuracy; analysis; auc; cases; characteristics; clinical; clinical features; common; coronavirus; correlations; covid-19; diagnosis; disease; features; fig; ggo; good; gray; images; imaging; lesions; level; logistic; matrix; model; moderate; novel; patients; pneumonia; predictive; radiomics; results; score; sensitivity; severe; severity; significant; specificity; study; test; textural; texture; values; wuhan
    • versions: original; plain text
86. cord-310205-j57x9ke6
    • author: Alcaide, Maria L.
    • title: Pharyngitis and Epiglottitis
    • date: 2007-06-08
    • words: 7569
    • flesch: 39
    • summary: The role of streptococcus in the pathogenesis of rheumatic fever Rapid diagnosis of pharyngitis caused by group A streptococci Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis Management of acute pharyngitis in adults: reliability of rapid streptococcal tests and clinical findings Treatment failures and carriers: perception or problems? Antibiotics for sore throat Are cephalosporins superior to penicillin for treatment of acute streptococcal pharyngitis? Principles of appropriate antibiotic use of acute pharyngitis in adults Antibiotic treatment of children with sore throat Antibiotic treatment of adults with sore throat by community primary care physicians: a national survey Clinical significance and pathogenesis of viral respiratory infections A collaborative study of the aetiology of acute respiratory infection in Britain 1961-4.
    • keywords: acute; acute pharyngitis; adenovirus; adults; agents; airway; american; amoxicillin; antibiotics; antimicrobial; antiretroviral; associated; available; beta; care; cases; cause; cervical; children; clinical; clinician; common; complications; culture; days; diagnosis; diphtheria; discussion; disease; duration; early; ebv; effective; efficacy; epidemiologic; epiglottitis; fever; findings; gas; gas pharyngitis; group; haemolyticum; hemolytic; high; hiv; human; illness; immunization; important; infection; laboratory; limited; lymphadenopathy; management; manifestations; mononucleosis; months; negative; onset; oral; organism; outbreaks; patients; penicillin; peritonsillar; pharyngeal; pharyngitis; pharynx; pneumoniae; positive; practice; presence; present; presentation; primary; radt; rare; rash; respiratory; results; rheumatic; risk; self; severe; sore; specific; states; streptococcal; streptococcal pharyngitis; studies; study; symptomatic; symptoms; syndrome; table; test; therapy; throat; treatment; type; united; upper; viral; virus; weeks; years; young
    • versions: original; plain text
87. cord-311806-3zy5kgo5
    • author: Leoni, Chiara
    • title: The dark side of COVID‐19: The need of integrated medicine for children with special care needs
    • date: 2020-06-24
    • words: 765
    • flesch: 35
    • summary: Valentina Giorgio acquired clinical data on Case 1 (first patient), reviewed, and revised the manuscript. LuigiTarani acquired clinical data on Case 3, reviewed, and revised the manuscript.
    • keywords: affected; care; case; children; clinical; complications; covid-19; data; disease; manuscript; medical; patients; rare; selicorni; syndrome; zampino
    • versions: original; plain text
88. cord-312677-rwznqiib
    • author: Razmi, Mahdieh
    • title: Immunomodulatory-Based Therapy as a Potential Promising Treatment Strategy against Severe COVID-19 Patients: A Systematic Review
    • date: 2020-08-29
    • words: 6565
    • flesch: 33
    • summary: A single center experience Tocilizumab treatment in severe COVID-19 patients attenuates the inflammatory storm incited by monocyte centric immune interactions revealed by single-cell analysis Favorable changes of CT findings in a patient with COVID-19 pneumonia after treatment with tocilizumab Off-label use of tocilizumab in patients with SARS-CoV-2 infection Pilot prospective open, single-arm multicentre study on off-label use of tocilizumab in severe patients with COVID-19 Tocilizumab therapy reduced intensive care unit admissions and/or mortality in COVID-19 patients Interleukin-6 blockade for severe COVID-19 Tocilizumab for the treatment of severe coronavirus disease 2019 Use of Tocilizumab for COVID-19-Induced Cytokine Release Syndrome: A Cautionary Case Report Acute hypertriglyceridemia in patients with COVID-19 receiving tocilizumab Tocilizumab for cytokine storm syndrome in COVID-19 pneumonia: an increased risk for candidemia? Use of siltuximab in patients with COVID-19 pneumonia requiring ventilatory support, medRxiv preprint Use of anakinra in severe COVID-19: a case report Targeting the inflammatory cascade with anakinra in moderate to severe COVID-19 pneumonia: case series Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells Treatment of Severe COVID-19 with human Umbilical Cord Mesenchymal Stem Cells Intravenous infusion of human umbilical cord Wharton's jellyderived mesenchymal stem cells as a potential treatment for patients with COVID-19 pneumonia Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19 Effectiveness of convalescent plasma therapy in severe COVID-19 patients Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma Treatment With Convalescent Plasma for Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection Treatment with convalescent plasma for COVID-19 patients in Wuhan, China Use of Convalescent Plasma Therapy in Two COVID-19 Patients with Acute Respiratory Distress Syndrome in Korea High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease Recovery of severely ill COVID-19 patients by intravenous immunoglobulin (IVIG) treatment: A case series Effect of regular intravenous immunoglobulin therapy on prognosis of severe pneumonia in patients with COVID-19 Clinical Efficacy of Intravenous Immunoglobulin Therapy in Critical Patients with COVID-19: WHO, Coronavirus disease 2019 (COVID-19) Situation Report -92 Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target Characteristics of and Public Health Responses to the Coronavirus Disease 2019 Outbreak in China Epidemiology, Pathogenesis, and Control of COVID-19 Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in COVID-19: immunopathology and its implications for therapy Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study COVID-19, immune system response, hyperinflammation and repurposing antirheumatic drugs Influence factors of death risk among COVID-19 patients in Wuhan, China: a hospital-based case-cohort study Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients Clinical features of patients infected with 2019 novel coronavirus in Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China Effective treatment of severe COVID-19 patients with tocilizumab COVID-19 infection: the perspectives on immune responses Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure Clinical features and treatment of COVID-19 patients in northeast Chongqing Transplantation of ACE2(-)
    • keywords: acute; administration; adverse; anakinra; analysis; anti; blood; case; cells; characteristics; china; clinical; cohort; control; convalescent; coronavirus; corticosteroid; cov-2; covid-19; covid-19 patients; cytokine; days; disease; dosage; dose; drugs; effective; efficacy; factors; findings; group; hcq; high; hydroxychloroquine; il-6; ill; immune; immunomodulatory; infected; infection; inflammatory; intravenous; ivig; medicines; mesenchymal; mortality; mscs; ncp; non; novel; outcomes; patients; plasma; pneumonia; potential; publications; purification; recovery; report; respiratory; responses; results; retrospective; review; risk; sars; search; severe; severe covid-19; single; storm; studies; study; syndrome; systematic; therapeutic; therapies; therapy; tocilizumab; treatment; trials; use; viral; wuhan
    • versions: original; plain text
89. cord-315598-qwh72inx
    • author: Mendoza, Jose Luis Accini
    • title: ACTUALIZACION DE LA DECLARACIÓN DE CONSENSO EN MEDICINA CRITICA PARA LA ATENCIÓN MULTIDISCIPLINARIA DEL PACIENTE CON SOSPECHA O CONFIRMACIÓN DIAGNÓSTICA DE COVID-19
    • date: 2020-10-06
    • words: 69660
    • flesch: 31
    • summary: y los que tienen menos probabilidades de beneficiarse (él «demasiado enfermo»), no prestan suficiente atención a las diferencias entre grupos en términos de la duración de los cuidados intensivos necesarios para lograr resultados. Se recomienda aplicar la escala SOFA al menos cada 48 horas sumado al criterio de fragilidad y años de vida saludables salvados estos criterios podrían ser válidos en pacientes con fallo terapéutico a las medidas óptimas y orientar decisiones de deescalamiento de medidas y de nivel de complejidad de atención cuando la demanda potencial supera la oferta (capacidad y capacidades), estas decisiones deben ser tomadas idealmente en junta médica.
    • keywords: 2019; 2020; acceso; acerca de; actual; actualmente; acuerdo con; acute; acute respiratory; adecuación de; adecuado; adecuado de; además de; adicional; adición de; adquirida en; adultos; adultos con; adversos; aguda; aguda en; aire; ajustar; ajustar el; al día; alguno de; algunos; altas; alteraciones; alteración; alto; alveolar; amci; americano de; analysis; antes; antes de; anticoagulación; antivirales; análisis de; aparición de; aplicación de; aquellos; aquellos con; ards; arterial de; asignación de; asistencial; asociada; asociado con; asociados; asoció con; assessment; associated; association; así; ataque; aumenta el; aumentar la; aumento de; aunque; ausencia de; aérea; años; aún; bajo; bajo la; basado en; base en; beneficio de; beneficios; bien; biomarcadores; bloqueo; bolsa; cadena de; cadáver; calidad de; camas; camas de; cambio en; cambios; cannula; cardiaca; cardiovascular; care; cases; casos de; casos y; catéter; central; cerebral; characteristics; choque; citoquinas; ciudad de; claro; clinical; clínica; clínica de; clínico en; clínicos; cohorte; colombia; combinación de; combinado de; comité de; como el; como la; como los; como se; como una; comorbilidades; comparación con; comparado con; compararon; complejidad de; complicaciones; componentes; compromiso; con alta; con amci; con aumento; con baja; con base; con comorbilidades; con compromiso; con covid-19; con dosis; con el; con enfermedad; con esta; con evidencia; con falla; con frecuencia; con hipoxemia; con ic; con infección; con la; con lopinavir; con los; con mayor; con mejoría; con menor; con más; con neumonía; con otros; con peep; con plasma; con presión; con que; con respecto; con riesgo; con sars; con sdra; con shock; con solución; con sospecha; con su; con síndrome; con tcz; con todo; con un; con uso; conciencia; condiciones de; condición; confirmación de; confirmado de; consenso; consensus; considerar la; considere; contagio; contar con; contenido de; continua; continuo de; contra; contra la; contra para; control; controles; convaleciente; convalescent; convertidora de; coronavirus; coronavirus covid-19; course; cov-2; covid-19 acute; covid-19 al; covid-19 covid-19; covid-19 infection; covid-19 pandemic; covid-19 pneumonia; crb-65; criterios de; critical; crítica; crítica y; críticamente; crítico con; cuadros de; cual se; cuales el; cuales se; cuando el; cuando la; cuando se; cuanto; cuenta con; cuenta la; cuenta que; cursan con; curso de; células; dados de; datos; de 1; de 3; de 7; de abril; de acuerdo; de aerosoles; de aerosolización; de aislamiento; de alerta; de alta; de amci; de anakinra; de anticuerpos; de antimaláricos; de apoyo; de arritmias; de atención; de baja; de base; de bioseguridad; de bioética; de cada; de capacitación; de citocinas; de clasificación; de cohorte; de consciencia; de consenso; de contacto; de contaminación; de control; de coronavirus; de corticoides; de corticosteroides; de covid-19; de cq; de crisis; de cuidados; de de; de desarrollar; de detección; de dexametasona; de dificultad; de disfunción; de disminuir; de dímero; de elementos; de emergencia; de encefalitis; de enfermedad; de ensayos; de entre; de epp; de esta; de estancia; de estos; de estudios; de evaluación; de expansión; de expertos; de falla; de fiebre; de fluidos; de flujo; de forma; de gasto; de hbpm; de hcq; de hipoxemia; de hospitalización; de igiv; de il-6; de infecciones; de infección; de ingreso; de interdependencia; de interferón; de intervención; de intubación; de la; de lactato; de letalidad; de linfocitos; de lopinavir; de los; de mal; de manera; de manos; de marzo; de menor; de monitoreo; de muerte; de norepinefrina; de novo; de obtener; de origen; de oxígeno; de pacientes; de paro; de pcr; de plasma; de protección; de recursos; de referencia; de respiración; de rutina; de salud; de segunda; de ser; de shock; de sobrevida; de sodio; de soporte; de su; de tcz; de tocilizumab; de trabajo; de transmisión; de triaje; de tórax; de un; de ventilación; de vida; de vista; de volumen; de wuhan; de ácidos; de ética; de éxito; de óxido; deben; deber de; deberá; debido; decisiones; decisiones de; definición de; definida; definir el; del; del sistema; del tracto; del virus; delirium; delphi; demostrado; dentro; dentro del; dependerá de; dependiente de; descrito; desde el; desde la; desenlaces; desinfectante; después de; deterioro; determinar la; diagnosis; diagnóstico covid-19; diagnóstico de; diciembre de; diferencias; diferentes; difícil; directa; disease; disminución de; disminución en; disminuir el; disminuye la; disponibilidad de; disponible; dispositivos; distress; documento; dolor; donde; dosis; dosis de; duración de; durante la; día por; días; días de; días en; días y; dímero; early; echocardiography; ecmo; edema; efectividad; efectos de; effect; eficacia; egreso; el acceso; el agente; el alta; el apoyo; el balance; el cadáver; el caso; el circuito; el colegio; el comité; el compromiso; el conocimiento; el consentimiento; el contexto; el contrario; el crb-65; el cual; el cuidado; el curso; el daño; el de; el deber; el desarrollo; el destete; el diagnóstico; el documento; el día; el ecmo; el efecto; el equipo; el espacio; el estudio; el examen; el familiar; el fin; el flujo; el grado; el grupo; el hospital; el impacto; el inicio; el lugar; el lóbulo; el manejo; el marco; el mayor; el menor; el mismo; el momento; el más; el médico; el nivel; el número; el paciente; el papel; el perfil; el plan; el plasma; el primer; el procedimiento; el pronóstico; el punto; el qsofa; el remdesivir; el rendimiento; el resultado; el retiro; el riesgo; el rigor; el sars; el score; el sdra; el seguimiento; el segundo; el tcz; el tiempo; el tipo; el transporte; el traslado; el uso; el ventilador; el área; el índice; elementos; elevación de; elevados de; elisa; embargo; emitir; emitir una; en algunos; en cada; en china; en contra; en cuenta; en donde; en el; en estado; en este; en falla; en la; en los; en otro; en quien; en salud; en su; en uci; en un; en wuhan; encima de; encontraron; enfermedad por; enfermedades; enfermería; enfermo; enfermo con; enteral; entre el; entre la; entre los; entrenamiento; epidemia de; epilépticas de; epp; equipo de; equipos; es importante; es una; escala; escasez de; escenarios; esfuerzo; española de; especialmente; especificidad; específico; espontánea; establecer; establecer el; estado de; estas; este; esteroides; esto se; estos pacientes; estrategia de; estrategias; estudio con; estudios para; está; estándar; esté; et al; evaluación; evaluar; evaluaron; evaluaron la; evaluó la; eventos; evidence; evidencia de; evidencia que; evitar el; evitar la; existe; extracorporeal; extubación; factores; failure; familiar; fase; fase de; favor; favor o; fenotipos; fin de; final de; finalmente; fio2; flow; flujo; frecuencia; frente; fue de; fue en; fue la; fuera de; fueron; fueron de; fuerte en; fundamento; fundamento el; fármacos; garanticen la; garantizar la; generación de; generador de; general; generales; generales de; gestión de; global; grado de; gran; gravedad de; graves; graves de; grupo de; grupos; guidance; guidelines; guía de; guías; h1n1; hacer; hacia; hallazgos; hallazgos de; hasta el; hasta la; hay; hcq y; health; hemodinámica; herramienta; high; higiene de; horas; hospitalaria; hospitales; hospitalizados; hubo; humano; huésped; hydroxychloroquine; ic del; identificación de; identificar; igm; igual; ill; implementación; implementar; importante; importante que; incidencia de; incluir; incluso; incluyendo; incremento; independientemente de; infección por; infected; infection; inferior; influenza; información; informado; inhibidor de; inicial; iniciales; inicio de; injury; inspirada de; institucional; insuficiencia; integridad de; intensidad; intensive; intensivista; intensivos en; intensivos y; intervenciones; intravenosa; intubados; intubation; invasiva; invasiva en; investigación; italia; kidney; la actualidad; la administración; la admisión; la adopción; la alta; la amci; la anatomía; la asociación; la cabecera; la capacidad; la carga; la ciudad; la compliance; la comunidad; la condición; la cual; la cánula; la decisión; la definición; la demanda; la detección; la dexametasona; la dificultad; la disnea; la disponibilidad; la distribución; la dosis; la duración; la ecografía; la edad; la eficacia; la elevación; la eliminación; la emergencia; la enfermedad; la entrada; la epidemia; la estabilidad; la estancia; la evidencia; la evolución; la experiencia; la exposición; la falla; la familia; la fase; la fda; la fecha; la fiebre; la función; la gestión; la gravedad; la guía; la habitación; la hcq; la hidroxicloroquina; la higiene; la hipoxemia; la historia; la hospitalización; la identificación; la igiv; la il-6; la incidencia; la infección; la influenza; la información; la inmunoglobulina; la institución; la intubación; la liberación; la literatura; la mayor; la mecánica; la membrana; la monitoria; la monitorización; la mortalidad; la muerte; la muestra; la n95; la neumonía; la nutrición; la opción; la oxigenación; la pandemia; la perfusión; la población; la posición; la presencia; la presión; la prevención; la primera; la probabilidad; la procalcitonina; la pronación; la proteína; la prueba; la radiografía; la reanimación; la recomendación; la recuperación; la relación; la respuesta; la rt; la sala; la salud; la saturación; la seguridad; la sensibilidad; la supervivencia; la tasa; la telesalud; la terapia; la tolerancia; la toma; la transfusión; la traqueostomía; la troponina; la técnica; la uci; la unidad; la utilización; la valoración; la variabilidad; la vasopresina; la vida; la vmni; la vía; laboratorio; las; las medidas; las personas; lesiones; lesión; leve; limitaciones; limitación de; limitar el; litro de; lograr; lopinavir; los biomarcadores; los cambios; los casos; los criterios; los cuales; los cuidados; los diferentes; los días; los efectos; los elementos; los epp; los equipos; los estudios; los factores; los familiares; los grupos; los hallazgos; los medicamentos; los médicos; los niveles; los participantes; los primeros; los procedimientos; los protocolos; los recursos; los residuos; los respiradores; los resultados; los servicios; los síntomas; los valores; los índices; luego de; lugar; lung; líderes de; línea de; líquidos; management; manejo con; manejo de; manifestaciones; mantener; mantener la; mascarilla; mayor; mayores; mayoría de; mechanical; mecánica; mediante; mediante la; medicamentos; medicina; medición de; medidas de; mejora de; mejorar la; mejoría; membrana; menor; mental; mental de; mers; meta; metaanálisis; metas de; ministerio de; minutos; miocárdica; mismo; mmhg; modalidades de; modelo de; modelos; moderado; moral de; mortality; mostraron; mostró; muerte; muestras; multicenter; multicéntrico; murieron; muy; más de; médica; múltiples; n95; n95 de; nacional; nasal; necesario; necesidad de; negativa; negativos; nervioso; neumonía por; neurological; neuromuscular; new; news-2; ninguno de; ningún; nivel de; niveles; noninvasive; novel; nutrition; número de; o las; o muerte; o más; o por; o que; o se; o sin; objetivo de; objetivos; observacional; ofrecer; opción; organización; orotraqueal; otra; otros; outcomes; oxigenación y; oxigenoterapia; oxygenation; oxígeno y; paciente por; pacientes adultos; pacientes con; pacientes covid-19; pacientes críticamente; pacientes críticos; pacientes fueron; pacientes infectados; pacientes que; pacientes recibieron; pacientes sin; pacientes tratados; pacientes y; pafi; page; paliativos; pao2; para el; para este; para evitar; para la; para los; para manejo; para pacientes; para que; para sars; para su; para una; paro; parte de; parámetros; pasiva de; patients; patologías; pcr; pcr para; peep; perfil de; permite; pero; pero en; pero se; personal de; personal y; personas; personas con; pesar de; peso; plan de; plantea la; plasma; pneumonia; podrían; por covid-19; por el; por esto; por la; por los; por sars; por su; por un; posibilidad de; posible; position; positioning; positiva; posterior; potencial; predecir la; predictores; preoxigenación; presenta; presentación; presentaron; pressure; prestación de; previamente; primeras; probable; procedimientos; proceso de; procesos; profesionales de; progresión; promedio de; promover la; prone; propone; protectora; protocolo de; protocolos; prueba de; pruebas; práctica; publicaciones; publicación; publicado; pueden; pulmonar; pulmonar en; puntaje; punto de; puntos; pérdida de; pública; qsofa; que; que el; que esta; que la; que los; que puede; que recibieron; que requieren; que se; que una; quien se; quienes; qué; randomized; razonable; realización de; realizado; realizar; recambio de; receptor de; recibieron; reclutamiento; recomendaciones de; recomendación se; recomienda como; recomienda la; recomienda que; recommendations; recuperado de; recursos; reducción de; reduce; reducir; reducir el; refiere; refractaria; relacionadas con; relacionados; relación con; renal; renal en; renal y; reportaron; reportes de; requerimiento; requiere; residuos; residuos de; resistencia; resolución de; respiratoria con; respiratoria y; respiratory; responsable; resultados; retiro de; retraso en; retrospectivo; review; revisión de; ribavirina; riesgo de; riesgo para; riesgos; risk; ritonavir; rutina la; rutinaria; rutinaria la; rutinario de; rápida; safety; salas; salud y; sanitario; sars; sars y; score; sdra y; se asoció; se debe; se encuentran; se han; se puede; se realiza; se recomienda; se sugiere; secuelas; sedación; segura; seguridad del; según la; sepsis; ser; ser el; ser una; serie de; series; servicios; servicios de; será; severa en; severe; severe covid-19; severidad de; severo de; shock; si el; si la; si los; si se; sido; siempre; siendo; siendo el; significativa de; significativamente; signos; signos de; siguientes; similar; simple de; sin; sin embargo; sin que; sintomatología; sistema; sistemática de; situaciones; situación de; sobre el; sobre la; sobre los; sobrevivientes; social; society; solo; solo el; son de; son el; son la; son los; sospecha de; spo2; study; su uso; suficiente; sugiere; superior; support; sus; syndrome; systematic; síndrome de; síntomas y; sólo; tabla; tamaño de; también; también se; tanto; tasa de; tasas; tcz; temperatura de; temprana; temprana de; tener; tener en; teniendo en; tenían; terapia con; terapéutico; therapy; tiempo de; tiempo y; tiempos; tiene; tienen el; time; tipo de; tocilizumab; todas; todo el; todos los; toma de; tomar; tomografía de; tormenta de; total de; trabajadores de; tracto; transmission; tras el; trastorno de; trata de; tratados con; tratamiento de; través; través de; treatment; trial; trombosis; troponina; tuvieron; técnicas; técnicas de; términos; uci con; uci de; uci y; ultrasound; un estudio; un grupo; un manejo; un mayor; un paciente; un protocolo; un tiempo; un uso; una; una estrategia; una o; una presión; una reducción; una revisión; una serie; una vez; unidad de; unidades; unit; usar; uso de; uso y; utilidad de; utilizando; utilizar; utilizar el; valorar la; valores; variables; varias; veces; ventilación mecánica; ventilador; ventilation; ventilatorio; versus; vez; vez se; vida y; viral; viral y; virus y; vitro; vmni; volumen; weaning; wuhan; y al; y bajo; y cols; y como; y con; y cuando; y de; y debe; y el; y en; y entre; y es; y estudios; y fueron; y la; y los; y manejo; y mayor; y mortalidad; y otros; y para; y por; y protección; y puede; y que; y riesgo; y se; y seguridad; y shock; y si; y soporte; y su; y tratamiento; y una; y ventilación; ® el; ® la; áreas; áreas de; ésta; éticos; índice de; óptimo; último; útil; útil para
    • versions: original; plain text
90. cord-315730-fzgxuak7
    • author: Penman, Sophie L.
    • title: Safety perspectives on presently considered drugs for the treatment of COVID‐19
    • date: 2020-07-17
    • words: 12087
    • flesch: 30
    • summary: As such, it is likely that many of the AEs observed in the Ebola study will translate to COVID-19 patients treated with remdesivir. However, a recent study found that only 4.1 % of COVID-19 patients receiving remdesivir treatment suffered serious (grade 3 or 4) transaminase elevations, with there being no significant difference between the remdesivir-and placebo-treated groups (Beigel et al., 2020) .
    • keywords: active; acute; administration; adverse; aes; agents; anakinra; analysis; anti; antiviral; arm; arthritis; article; associated; azithromycin; baricitinib; benefit; beta; biovitrum; cardiac; cardiovascular; care; cases; cause; cell; channel; clinical; cmax; combination; common; compounds; concentrations; concern; control; copyright; coronavirus; corticosteroids; cov-2; covid-19; covid-19 patients; cytokines; daily; data; days; dependent; dexamethasone; disease; dose; drug; ebola; effect; efficacy; enzyme; et al; events; evidence; example; excellence; exposure; favipiravir; following; function; gilead; group; health; high; higher; human; hydroxychloroquine; ifn; il-6; immune; inadequate; increase; induced; infection; inflammatory; inhibition; inhibitors; injury; institute; interactions; interferon; intravenous; kidney; known; lancet; levels; life; likely; liver; long; lopinavir; low; ltd; management; medicines; mers; methotrexate; moderate; mortality; multiple; national; need; novel; number; order; orphan; outcomes; patients; phase; placebo; plasma; pneumonia; post; potential; prolongation; prophylaxis; protein; randomized; reactions; recent; receptor; recovery; related; remdesivir; renal; replication; respiratory; response; results; review; rheumatoid; rheumatoid arthritis; rights; risk; ritonavir; rna; safety; sarilumab; sars; severe; short; siltuximab; single; site; small; studies; study; subcutaneous; swedish; symptoms; syndrome; systematic; term; therapeutic; therapies; therapy; thrombotic; time; tocilizumab; toxicity; treatment; trial; use; viral; vitro; world; β-1
    • versions: original; plain text
91. cord-316029-z708c3ex
    • author: Brunsdon, Priya
    • title: Clinical Pharmacology Considerations for Developing Small‐Molecule Treatments for COVID‐19
    • date: 2020-07-12
    • words: 4969
    • flesch: 32
    • summary: A systematic review Gentamicin volume of distribution in critically ill septic patients Antimicrobial pharmacokinetic and pharmacodynamic issues in the critically ill with severe sepsis and septic shock Effect of alpha-1-acid glycoprotein binding on pharmacokinetics and pharmacodynamics Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Impact of infectious and inflammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics The Impact of Renal Impairment on Patient Drug Response -Assessing the Need for a Consensus Approach Acute kidney injury in patients hospitalized with COVID-19 Kidney involvement in COVID-19 and rationale for extracorporeal therapies COVID-19 and kidney failure in the acute care setting: our experience from Seattle Pharmacokinetic principles during continuous renal replacement therapy: drugs and dosage Assessment of the impact of renal impairment on systemic exposure of new molecular entities: evaluation of recent new drug applications Hydroxychloroquine as an aerosol might markedly reduce and even prevent severe clinical symptoms after SARS-CoV-2 infection Virological assessment of hospitalized patients with COVID-2019 Working to supply remdesivir for COVID-19 Inhalation drug delivery devices: technology update A review of nebulized drug delivery in COPD Determination of the relative bioavailability of salbutamol to the lungs and systemic circulation following nebulization Practical strategies for a safe and effective delivery of aerosolized medications to patients with COVID-19 A guide to drug therapy in patients with enteral feeding tubes: dosage form selection and administration methods Therapeutic concerns when oral medications are administered nasogastrically Clogged feeding tubes: a clinician's thorn Medication administration through enteral feeding tubes Estimates of the severity of coronavirus disease 2019: a model-based analysis A call for the appropriate application of clinical pharmacological principles in the search for safe and efficacious COVID-19 (SARS-COV-2) treatments Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease Rates of Cases, Hospitalizations and Deaths by Race/Ethnicity Group COVID-19: They are based on the major observed disease complications that impact drug absorption, distribution, metabolism, and elimination.
    • keywords: absorption; acute; addition; administration; binding; blood; care; cases; changes; clinical; complications; concentrations; considerations; coronavirus; cov-2; covid-19; delivery; development; disease; distribution; dose; dosing; drug; efficacy; exposure; feeding; gastric; hemodialysis; ill; impact; impairment; increase; infection; inhalation; interactions; intravenous; investigational; kidney; medications; need; new; oral; patients; pharmacokinetic; pharmacology; population; potential; remdesivir; renal; respiratory; response; risk; sars; sepsis; septic; severe; shock; site; stage; studies; study; subjects; symptoms; systemic; therapeutic; therapies; therapy; time; treatment; tubes; use; viral
    • versions: original; plain text
92. cord-316432-xemz7zn9
    • author: Talaie, Haleh
    • title: Is there any potential management against COVID-19? A systematic review and meta-analysis
    • date: 2020-08-18
    • words: 5097
    • flesch: 33
    • summary: National Institutes of Health Drug-eluting stents versus bare metal stents for saphenous vein graft revascularisation: a meta-analysis of randomised trials Immunosuppressive drugs to reduce the mortality rate in patients with moderate to severe paraquat poisoning: a meta-analysis Legionella prevalence and risk of legionellosis in Japanese households Quantifying heterogeneity in a metaanalysis Bioaccumulation of potentially toxic elements (PTEs) in muscleTilapiaspp fish: a systematic review, meta-analysis, and non-carcinogenic risk assessment Toxocara eggs in public places worldwide-a systematic review and meta-analysis The global seroprevalence of toxoplasma gondii in pigs: a systematic review and meta-analysis The global seroprevalence of toxoplasma DARU J Pharm Sci gondii among wild boars: a systematic review and meta-analysis Seroprevalence estimates for toxocariasis in people worldwide: A systematic review and meta-analysis Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial Lopinavir-ritonavir versus hydroxychloroquine for viral clearance and clinical improvement in patients with mild to moderate coronavirus disease 2019 Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with COVID-19 in New York state Full-length title: Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France Lack of viral clearance by the combination of hydroxychloroquine and azithromycin or lopinavir and ritonavir in SARS-CoV-2-related acute respiratory distress syndrome Treatment Response to Hydroxychloroquine, Lopinavir/Ritonavir, and Antibiotics for Moderate COVID 19: A First Report Pharmacol Outcomes South Korea. medRxiv Effect of convalescent plasma therapy on time to clinical improvement in patients with severe and life-threatening COVID-19: a randomized clinical trial Treatment of 5 critically ill patients with COVID-19 with convalescent plasma Treatment with convalescent plasma for COVID-19 patients in Wuhan Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Convalescent Plasma Mortality reduction in 46 severe Covid-19 patients treated with hyperimmune plasma.
    • keywords: acute; administration; agents; analysis; antiviral; arbidol; articles; azithromycin; cases; clinical; cochrane; cohort; convalescent; conversion; coronavirus; cov-2; covid-19; current; disease; drug; effect; effective; efficacy; hcq; health; hydroxychloroquine; i(2; icu; illness; immunomodulatory; improvement; infection; interventions; lopinavir; mechanical; medications; meta; mortality; negative; outcomes; pandemic; patients; plasma; pneumonia; potential; quality; randomized; rate; rcts; remdesivir; respiratory; results; retrospective; review; risk; ritonavir; sars; severe; significant; single; studies; study; syndrome; systematic; systematic review; therapeutic; therapy; time; tocilizumab; treatment; trial; value; ventilation
    • versions: original; plain text
93. cord-316647-jj8anf5g
    • author: Shang, You
    • title: Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China
    • date: 2020-06-06
    • words: 13606
    • flesch: 35
    • summary: However, considering the suggestion that restrictive fluid volume management strategy should be adopted for COVID-19 patients complicated by ARDS based on the premise of sufficient tissue perfusion, we suggest CRRT initiation in severe patients within 24 h when they show rank 2 AKI under KDIGO criteria or accompanied with cytokine storm syndrome. There are still no targeted therapies for COVID-19 patients.
    • keywords: acute; acute respiratory; adults; aerosol; airway; aki; analysis; anxiety; ards; associated; available; bronchoscopy; cardiac; care; cases; cells; china; chinese; clinical; coagulation; cohort; common; confirmed; control; convalescent; coronavirus; covid-19; covid-19 patients; criteria; critical; crrt; data; day; deep; delirium; diagnosis; disease; disposable; distress; dysfunction; early; ecmo; effect; equipment; evidence; experience; expert; factors; failure; fluid; gas; grade; guidelines; health; healthcare; heparin; hfnc; high; higher; hospital; hypoxemia; icu; ill; ill covid-19; ill patients; immune; improved; incidence; increase; indications; infection; influenza; injury; intensive; intubation; invasive; kidney; level; low; lower; lung; management; mechanical; medical; meta; mild; mmhg; mortality; myocardial; need; niv; non; novel; nutrition; opinion; outbreak; outcomes; oxygen; oxygenation; pain; pandemic; pao; patients; plasma; pneumonia; points; poor; positioning; positive; possible; pressure; prevention; previous; procedures; prognosis; prone; randomized; rate; rationale; recommendation; recruitability; recruitment; related; remdesivir; removal; renal; resources; respiratory; response; responsiveness; review; risk; sars; secondary; sedation; sepsis; severe; severe covid-19; severity; sleep; society; stage; standard; statement; stay; strategy; strong; studies; study; support; symptoms; syndrome; systematic; therapy; time; treatment; trial; unit; use; ventilation; volume; weak; workers; wuhan
    • versions: original; plain text
94. cord-316886-qzka2dqm
    • author: Machin, L. L.
    • title: Making the (Business) Case for Clinical Ethics Support in the UK
    • date: 2020-07-21
    • words: 9312
    • flesch: 32
    • summary: We conclude that there is a real need for investment in clinical ethics in the UK in order to build the evidence base required to support the wider introduction of clinical ethics support into UK hospitals. A review of the research evidence Twelve tips for running teaching programmes for newly qualified doctors When healthcare professionals cannot do the right thing: A systematic review of moral distress and its correlates Paediatrics at the cutting edge: Do we need clinical ethics committees Managing the threat to reflective writing Nursing ethics and the ethical nurse Ethical dilemmas: A focus of discussion for junior doctors Educational needs of foundation doctors caring for dying patients Amenable to reason: Aristotle's Rhetoric and the moral psychology of practical ethics Ethics in the medical undergraduate curriculum: Encouraging thinking in the midst of cramming facts s/Other -Topic s/QS-chall enge-repor ts/Clini cal-Ethic s-Netwo rk-Final -Repor t.pdf Interprofessional education and practice guide: Designing ethics-orientated interprofessional education for health and social care students Exploring the perceived medical ethics and law training needs of UK foundation doctors Clinical ethics and systems thinking Novel paths to relevance: How clinical ethics committees promote ethical reflection Clinicians need better access to ethics advice, report says Health policy, patient-centred care and clinical ethics Can UK clinical ethics committees improve quality of care?
    • keywords: application; approach; association; available; benefits; board; business; business case; case; cess; challenges; clinical; clinical ethics; clinicians; colleagues; committees; community; conflicts; consultation; cost; culture; decision; development; dilemmas; discussions; distress; doctors; education; emotional; et al; ethical; ethicists; ethics; ethics committees; ethics support; everyday; evidence; example; exist; experiences; financial; focus; foundation; great; healthcare; hospital; individual; influence; institutional; introduction; issues; key; lack; law; leaders; legal; level; life; literature; making; medical; meeting; members; moral; need; nhs; order; organisation; paper; particular; patients; practice; problem; professionals; proposal; quality; reflection; reports; research; role; school; senior; service; setting; shift; staff; support; system; time; training; trust; ukcen; uncertainty; use; value; work
    • versions: original; plain text
95. cord-317952-4oa9hfb4
    • author: Bourgonje, Arno R.
    • title: Angiotensin‐converting enzyme‐2 (ACE2), SARS‐CoV‐2 and pathophysiology of coronavirus disease 2019 (COVID‐19)
    • date: 2020-05-17
    • words: 12115
    • flesch: 33
    • summary: Safety concerns of clinical images and skin biopsies Urticarial eruption in COVID-19 infection A case of COVID-19 pneumonia in a young male with full body rash as a presenting symptom Reply to COVID-19 can present with a rash and be mistaken for Dengue: Petechial rash in a patient with COVID-19 infection COVID-19 can present with a rash and be mistaken for Dengue Immune thrombocytopenic purpura in a patient with Covid-19 A distinctive skin rash associated with Coronavirus Disease Cutaneous manifestations in COVID-19: a first perspective Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study A case report of neonatal COVID-19 infection in China Novel coronavirus infection and pregnancy Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn Unlikely SARS-CoV-2 vertical transmission from mother to child: A case report Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China Vertical transmission of coronavirus disease 2019 (COVID-19) from infected pregnant mothers to neonates: Possible explanations of male predominance among COVID-19 patients may be differences in exposure, smoking behaviour, other lifestyle factors, differences in chromosomal ACE2 expression, ACE2 expression in testicular tissue, sex hormone-driven immune system regulation, or gender differences in RAAS regulation [37, [42]
    • keywords: ace2; ace2 expression; aceis; activity; acute; addition; aki; alveolar; analysis; angiotensin; anti; antiviral; arbs; article; associated; available; binding; blockade; blood; cardiac; cardiovascular; case; cells; changes; characteristics; china; chronic; clinical; complications; converting; copyright; coronavirus; coronavirus disease; course; cov-2; covid-19; covid-19 patients; crucial; cytokine; damage; death; development; differences; different; direct; disease; drugs; effects; elevated; endothelial; entry; enzyme; epithelial; events; evidence; expression; factors; failure; findings; function; future; gastrointestinal; genetic; hcq; heart; higher; host; human; hydroxychloroquine; hypertension; ibd; icu; ill; immune; important; infected; infection; inflammation; inflammatory; inhibition; inhibitors; initial; injury; involvement; kidney; leptin; levels; liver; lung; management; manifestations; mechanisms; mice; mortality; myocardial; ncov; novel; obesity; observed; organs; pandemic; pathogenesis; pathological; pathology; pathophysiology; patients; phase; plasma; pneumonia; populations; potential; present; protein; pulmonary; raas; recent; receptor; regulation; related; renal; renin; report; respiratory; response; results; review; rights; risk; rna; role; sars; severe; severity; sex; single; skin; small; specific; spike; storm; strategies; studies; study; susceptibility; symptoms; syndrome; system; systemic; target; therapeutic; therapy; thrombosis; time; tissue; tocilizumab; tract; transmission; treatment; trials; type; use; vertical; viral; vitro; women; wuhan
    • versions: original; plain text
96. cord-318209-llucxztc
    • author: Öztürk, Selçuk
    • title: Therapeutic Applications of Stem Cells and Extracellular Vesicles in Emergency Care: Futuristic Perspectives
    • date: 2020-08-24
    • words: 13636
    • flesch: 29
    • summary: A phase-1 clinical trial investigating autologous BM-derived mononuclear cell (BM-MNC) infusion in pediatric TBI patients indicated that Fig. 1 Main pathological conditions requiring acute emergency care that can benefit from stem cell therapies or extracellular vesicle therapies in the future harvesting and infusion of stem cells is safe in children with no infusion related toxicity or death A recently published systematic review of 76 studies testing stem cells in rodent ischemic stroke models and 4 randomized human clinical trials encompassing ischemic stroke patients treated with autologous stem cells with at least one year follow-up period demonstrated that stem cell therapies show beneficial effects in terms of behavior and histological outcomes in rodents.
    • keywords: activity; acute; addition; adipose; administration; agents; allogeneic; analysis; angiogenesis; animal; applications; approaches; ards; ars; autologous; beneficial; biological; bone; brain; burn; capacity; cardiac; cardiovascular; care; cargo; cell therapies; cell therapy; cells; characteristics; clinical; comparative; conditions; cord; covid-19; cutaneous; damage; data; death; delivery; different; differentiation; diseases; distress; diverse; dose; effective; effects; efficacy; emergency; encouraging; evidence; evs; example; exosomes; extracellular; factors; failure; free; functions; future; group; growth; hand; healing; heart; high; human; immune; improved; induced; inflammation; inflammatory; infusion; injection; injuries; injury; ipscs; ischemic; isolation; issues; large; limitations; limited; local; lung; management; marrow; medicine; medium; mesenchymal; mesenchymal stem; meta; mice; microvesicles; mirnas; models; mortality; mscs; need; neurological; new; novel; order; organ; outcomes; paracrine; patients; phase; pluripotent; pneumonia; possible; potential; preclinical; previous; process; processes; progenitor; promise; promising; radiation; recent; recovery; regenerative; related; repair; research; respiratory; response; results; review; risk; role; route; safety; sci; sepsis; severe; significant; similar; skin; small; sources; specific; stem; stem cells; strategies; stroke; stromal; studies; study; superior; survival; syndrome; systemic; tbi; terms; therapeutic; therapies; therapy; time; tissue; translation; transplantation; trauma; traumatic; treatment; trials; types; use; vesicles; wound
    • versions: original; plain text
97. cord-319805-b6ypt5d0
    • author: Siepmann, Timo
    • title: Association of history of cerebrovascular disease with severity of COVID-19
    • date: 2020-08-06
    • words: 5102
    • flesch: 36
    • summary: Investigation of early cohorts of COVID-19 patients in China focused on the effects of classic cardiovascular risk factors such as arterial hypertension and coronary heart disease or comorbidity in general [6, 7] . To approach this question, we assessed individual multicenter data from three cohorts of COVID-19 patients treated during the first months of the pandemic in Germany.
    • keywords: analysis; april; articles; association; available; cardiovascular; care; cerebrovascular; characteristics; china; clinical; clusters; cohort; commission; coronavirus; course; cov-2; covid-19; covid-19 patients; critical; cvd; data; death; diagnosis; disease; evidence; factors; failure; germany; health; heterogeneity; history; hospital; icu; individual; intensive; laboratory; literature; moderate; multicenter; national; necessity; non; observational; order; outcomes; pandemic; parameters; past; patients; pneumonia; pooled; previous; respiratory; retrospective; risk; sars; search; severe; severe covid-19; severity; stroke; studies; study; systematic; treatment; wuhan
    • versions: original; plain text
98. cord-319933-yp9ofhi8
    • author: Ruiz, Sara I.
    • title: Chapter 38 Animal Models of Human Viral Diseases
    • date: 2013-12-31
    • words: 28862
    • flesch: 41
    • summary: Wild-type C57BL/6 adult mice are not permissive to chikungunya virus infection by intradermal inoculation. [Comparative Study Research Support Characterization of clinical and immune response in a rotavirus diarrhea model in suckling Lewis rats Development of a heterologous model in germfree suckling rats for studies of rotavirus diarrhea Studies of oral rehydration solutions in animal models Induction of mucosal immune responses and protection against enteric viruses: rotavirus infection of gnotobiotic pigs as a model Developmental immunity in the piglet Swine in biomedical research Neonatal calf diarrhea induced by rotavirus Characterisation of the primary local and systemic immune response in gnotobiotic lambs against rotavirus infection Experimental infection of non-human primates with a human rotavirus isolate Development of a rotavirus-shedding model in rhesus macaques, using a homologous wild-type rotavirus of a new P genotype Reflections on 30 years of AIDS HIVs and their replication The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice Hematopoietic stem cell-engrafted NOD/ SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses HIV-1 infection and CD4 T cell depletion in the humanized Rag2Ã�/Ã� gamma cÃ�/Ã� (RAG-hu) mouse model HIV-1 infection and pathogenesis in a novel humanized mouse model Induction of robust cellular and humoral virusspecific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(þ) T cell decline in humanized mice Mucosal immunity and vaccines Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1 Propagation and dissemination of infection after vaginal transmission of simian immunodeficiency virus Limited dissemination of pathogenic SIV after vaginal challenge of rhesus monkeys immunized with a live Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase SIV-induced impairment of neurovascular repair: a potential role for VEGF Therapeutic DNA vaccine induces broad T cell responses in the gut and sustained protection from viral rebound and AIDS in SIV-infected rhesus macaques A Nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcgammaRIIIamediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: implications for treatment and postexposure prophylaxis Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection SHIV-1157i and passaged progeny viruses encoding R5 HIV-1 clade C env cause AIDS in rhesus monkeys Update on animal models for HIV research Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody Macaque studies of vaccine and microbicide combinations for preventing HIV-1 sexual transmission Vpx is Critical for SIVmne infection of pigtail macaques Impact of short-term HAART initiated during the chronic stage or shortly post-exposure on SIV infection of male genital organs The rhesus macaque pediatric SIV infection modeld a valuable tool in understanding infant HIV-1 pathogenesis and for designing pediatric HIV-1 prevention strategies Perinatal transmission of SHIV-SF162P3 in Macaca nemestrina Immune and genetic correlates of vaccine protection against mucosal infection by SIV in monkeys Chronic administration of tenofovir to rhesus macaques from infancy through adulthood and pregnancy: summary of pharmacokinetics and biological and virological effects Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the step study): a double-blind, randomised, placebo-controlled, test-of-concept trial Human papillomavirus in cervical cancer Human papillomavirus research: do we still need animal models? Animal models of papillomavirus pathogenesis Evidence of human papillomavirus vaccine effectiveness in reducing genital warts: an analysis of California public family planning administrative claims data The rabbit viral skin papillomas and carcinomas: a model for the immunogenetics of HPV-associated carcinogenesis Protection of beagle dogs from mucosal challenge with canine oral papillomavirus by immunization with recombinant adenoviruses expressing codon-optimized early genes Naturally occurring, nonregressing canine oral papillomavirus infection: host immunity, virus characterization, and experimental infection Regression of canine oral papillomas is associated with infiltration of CD4þ and CD8þ lymphocytes Characterization and experimental transmission of an oncogenic papillomavirus in female macaques A multimeric L2 vaccine for prevention of animal papillomavirus infections Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7 US doctors investigate more than 50 possible cases of monkeypox Isolation of monkeypox virus from wild squirrel infected in nature Reemergence of monkeypox: prevalence, diagnostics, and countermeasures Human monkeypox infection: a family cluster in the midwestern United States Human monkeypox and other poxvirus infections of man The confirmation and maintenance of smallpox eradication Human monkeypox Identification of wild-derived inbred mouse strains highly susceptible to monkeypox virus infection for use as small animal models A prairie dog animal model of systemic orthopoxvirus disease using west African and Congo Basin strains of monkeypox virus Comparison of monkeypox viruses pathogenesis in mice by in vivo imaging Comparative pathology of North American and central African strains of monkeypox virus in a ground squirrel model of the disease Experimental infection of an African dormouse (Graphiurus kelleni) with monkeypox virus A mouse model of lethal infection for evaluating prophylactics and therapeutics against monkeypox virus Experimental infection of ground squirrels (Spermophilus tridecemlineatus) with monkeypox virus Experimental infection of prairie dogs with monkeypox virus Experimental infection of cynomolgus macaques (Macaca fascicularis) with aerosolized monkeypox virus The pathology of experimental aerosolized monkeypox virus infection in cynomolgus monkeys (Macaca fascicularis) Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox Smallpox vaccine does not protect macaques with AIDS from a lethal monkeypox virus challenge Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus Virulence and pathophysiology of the Congo Basin and west African strains of monkeypox virus in non-human primates
    • keywords: able; activity; acute; adapted; adult; aerosol; african; age; aids; analysis; animal; animal models; anorexia; antibodies; antibody; antiviral; asymptomatic; attenuated; avian; b virus; balb; bats; birds; blood; brain; cases; cause; cells; central; challenge; changes; characterization; characterized; chikungunya; children; chimpanzees; chronic; clinical; clinical disease; clinical signs; cns; common; comparative; congo; contact; coronavirus; cotton; course; cov; cov infection; crimean; cynomolgus; damage; days; death; dengue; dengue virus; dependent; develop; development; diarrhea; different; disease; disease model; distribution; dogs; dose; drug; early; ebov; eeev; effective; efficacy; encephalitis; encephalitis virus; encephalomyelitis; enzymes; equine; experimental; experimental infection; exposure; failure; fatal; fatality; features; ferrets; fever; fever virus; filovirus; form; guinea; h5n1; hamsters; hantavirus; health; heart; hemorrhagic; hendra; hendra virus; hepatitis; high; histopathological; hiv; hiv-1; horses; host; human; human disease; human infection; illness; immune; immunity; important; individuals; induced; infant; infected; infection; infection model; inflammation; influenza; influenza infection; influenza virus; initial; inoculation; interferon; interstitial; intracerebral; intranasal; intraperitoneal; intratracheal; involvement; isolate; knockout; laboratory; lack; lassa; lesions; lethal; lethality; lethargy; levels; like; limited; liver; loss; low; lower; lungs; lymph; macaca; macaques; major; manifestations; marmosets; mice; mild; model; monkeypox; monkeypox virus; monkeys; mortality; mosquitoes; mouse; mouse model; mpxv; mucosal; natural; necrosis; nervous; neurological; new; nhps; nile; nile virus; nipah; nipah virus; nodes; nonhuman; norovirus; novel; number; old; onset; oral; outbreak; papillomavirus; paralysis; passaged; pathogenesis; pathogenic; pathology; patients; period; peripheral; person; phase; pigs; pneumonia; pneumonitis; poliovirus; possible; postexposure; postinfection; potential; present; prevention; primary; primates; progression; protection; pulmonary; rabies; rabies virus; range; rate; rats; receptor; recombinant; related; replication; reported; research; respiratory; respiratory disease; response; responsible; results; rhesus; rhesus macaques; rift; role; rotavirus; route; sars; severe; severe disease; shedding; signs; similar; siv; small; smallpox; species; spleen; spread; states; strains; studies; study; subcutaneous; susceptibility; susceptible; symptoms; syncytial; syncytial virus; syndrome; syrian; system; test; testing; therapeutics; time; tissues; tract; transmission; treatment; type; understanding; united; upper; useful; vaccine; vaginal; valley; veev; venezuelan; viral; viremia; virulence; virus; virus experimental; virus infection; virus pathogenesis; viruses; weeks; weev; weight; west; western; wild; wnv; world; years; young
    • versions: original; plain text
99. cord-323940-ubazgvov
    • author: Cafiero, Concetta
    • title: Pharmacogenomics and Pharmacogenetics: In Silico Prediction of Drug Effects in Treatments for Novel Coronavirus SARS-CoV2 Disease
    • date: 2020-10-13
    • words: 7372
    • flesch: 26
    • summary: • PharmGKB website provides a diverse array of PGx information, from annotations of the primary literature to guidelines for adjusting drug treatment based on genetic information. To our knowledge, although a considerable number of ADR episodes in Covid-19 patients have to date been described in the literature, there has been no pharmacogenetic study attempting to correlate the clinical outcomes of drug treatment with gene variants.
    • keywords: ace2; activity; acute; administration; adrs; adverse; agents; allele; analysis; antiretroviral; antiviral; associated; association; atazanavir; blood; cases; cell; clinical; cohort; combination; complications; conjunctivitis; coronavirus; cov2; covid-19; covid-19 patients; covid-19 therapy; covid-19 treatment; cyp3a5; cytokine; data; date; development; disease; dose; drug; early; effects; efficacy; evidence; factors; favipiravir; findings; genes; genetic; genome; group; hcq; high; hiv; hydroxychloroquine; identification; il6; individual; infection; inflammatory; information; inhibitors; interaction; international; literature; lopinavir; lung; management; medicine; novel; nucleotide; ocular; outcomes; patients; personalized; pharmacogenetic; pharmacological; pharmgkb; pneumonia; polymerase; polymorphisms; possible; potential; presence; present; protease; reactions; receptor; related; remdesivir; respiratory; response; retinal; review; ribavirin; risk; ritonavir; rna; sars; screening; sequence; severe; silico; single; snps; specific; stage; studies; study; symptoms; syndrome; system; table; testing; tests; therapeutic; therapy; tissue; toxicity; treatment; trials; use; useful; utility; variants; variations; viral; wide
    • versions: original; plain text
100. cord-324388-onc441uw
     • author: Siddiqui, Urooj
     • title: Same-Day Consent for Regional Anesthesia Clinical Research Trials: It’s About Time
     • date: 2020-08-12
     • words: 3589
     • flesch: 28
     • summary: Unfortunately, however, this long-standing workaround is fraught with challenges in appropriate recruitment of participants in that patients attending PACs are likely to be sicker and thus ineligible for study inclusion than those fitter patients who do not attend PAC 15 and are more likely eligible for regional anesthesia clinical research. Yet, our current understanding of patients' ability to provide same-day consent, 16, 17 the lack of evidence of perceived or actual coercion, the perceived value of the fiduciary relationship with the physician performing the procedure, [16] [17] [18] and its low-risk nature would seem to mandate a reconsideration of the absolute prohibition on obtaining same-day consent for regional anesthesia clinical research instead of seeking to create more workaround solutions which may be more disruptive to patients and generate more patient anxiety.
     • keywords: anesthesia; anesthesia clinical; anesthesia research; anxiety; approach; autonomy; benefits; care; clinical; clinical research; clinical trials; coercion; consent; covid-19; day; day consent; decision; ethical; guidelines; health; information; informed; investigators; low; nhs; pac; pandemic; participants; participation; patients; perioperative; potential; practice; process; proportionate; radiology; rebs; recruitment; regional; regional anesthesia; research; research trials; risk; setting; study; surgery; time; trials
     • versions: original; plain text
101. cord-324607-rpwccvqi
     • author: Rojek, Amanda M
     • title: Core Minimal Datasets to Advance Clinical Research for Priority Epidemic Diseases
     • date: 2020-02-15
     • words: 1261
     • flesch: 29
     • summary: Among the noteworthy successes of vaccine trials, and the commendable efforts to implement clinical treatment trials during Ebola outbreaks, we should also focus on strengthening the collection and curation of epidemiological and observational data that can improve the conception and design of clinical research. Any diagnostics, drugs, or vaccines that are developed as a result of this and other initiatives, such as the Coalition for Epidemic Preparedness Innovation, will need to be fully evaluated in diagnostic evaluation studies or phase II and III clinical trials.
     • keywords: analysis; available; care; case; clinical; collection; core; data; design; development; disease; ebola; epidemic; health; heterogeneity; laboratory; minimal; need; outbreaks; outcome; patient; priority; research; systematic; treatment; trial; virus
     • versions: original; plain text
102. cord-325559-di8lljoi
     • author: Cappello, Francesco
     • title: Does SARS-CoV-2 Trigger Stress-Induced Autoimmunity by Molecular Mimicry? A Hypothesis
     • date: 2020-06-29
     • words: 5212
     • flesch: 36
     • summary: By resorting to previously known information on genome sequences and protein structures and functions as well, bioinformaticians have been successfully assisting virologists by structurally characterizing proteins of the novel virus, determining the evolutionary trajectories, identifying interactions with host proteins, and providing other important biological insights. Alphavirus Sequence alignment of structural polyproteins belonging to arthritogenic alphaviruses revealed conserved regions which share homology with human proteins implicated in rheumatoid arthritis.
     • keywords: activation; acute; ade; aminotransferase; analysis; antibodies; antigens; autoantibodies; autoimmunity; available; blood; body; cases; cells; chaperones; chemokine; clinical; clues; coronavirus; cov-2; covid-19; cross; damage; data; dic; disease; drugs; epitopes; example; factors; generalized; higher; host; hsp; hsp60; human; hypothesis; il6; immune; infection; inflammatory; information; innate; laboratory; levels; lower; mechanism; medical; membrane; mimicry; molecular; motif; novel; pathogenesis; pathogenic; patients; phenomena; plasma; platelet; pneumonia; proteins; research; researchers; respiratory; response; sars; scientific; severe; spike; step; stress; structural; syndrome; system; systemic; table; time; upper; viral; virus
     • versions: original; plain text
103. cord-326331-g4o3forj
     • author: Rai, Ansaar T
     • title: Neuroendovascular clinical trials disruptions due to COVID-19 potential future challenges and opportunities
     • date: 2020-06-30
     • words: 3463
     • flesch: 39
     • summary: All were involved in neurovascular clinical trials as site principal investigators and six were leading clinical trials as national principal investigators. Similar guidelines were issued by the European Medicines Agency on the management of clinical trials during the COVID-19 pandemic on April 28, 2020 (https:// ec.
     • keywords: acute; aneurysm; arm; care; challenges; clinical; clinical trials; conduct; consent; coordinators; covid-19; disease; disruption; effect; endovascular; enrollment; figure; follow; future; group; guidance; impact; institutional; investigators; majority; missed; neurointerventional; neurovascular; pandemic; patients; physician; potential; procedures; questions; rcts; remote; research; response; review; single; sites; sponsors; stroke; studies; study; survey; suspension; time; trials; writing
     • versions: original; plain text
104. cord-327738-i400ynjp
     • author: Milner, Ross
     • title: Is it Ethically Appropriate to Continue Surgical Clinical Trials During the COVID-19 Pandemic? EDITED BY DR SARR
     • date: 2020-04-27
     • words: 1754
     • flesch: 32
     • summary: We discuss here the ethics of clinical trial care within the surgical specialties and the the pros and cons of participation in clinical trial during the COVID-19 pandemic, with a specific focus on surgical oncology and vascular surgery. The status of surgical clinical trials during this pandemic has not been addressed.
     • keywords: cancer; care; clinical; clinical trials; covid-19; decision; devices; disease; ethical; focus; health; hospital; issues; novel; operative; outcomes; pandemic; patients; potential; procedures; resources; risk; status; surgeons; surgery; surgical; time; treatment; trials; vascular
     • versions: original; plain text
105. cord-331268-kzy33hdb
     • author: Lynch, Sharon G.
     • title: Multiple sclerosis
     • date: 1996-01-31
     • words: 13858
     • flesch: 43
     • summary: Multiple sclerosis and human Tcell lymphotrophic retroviruses Amplification and molecular cloning of HTLV-I sequences from DNA of multiple sclerosis patients HTLV1 and tropical spastic paraparesis The G and Brahic M analysis of human Tlymphotrophic virus sequences in multiple sclerosis tissue Serologic studies of MS patients, controls, and patients with other neurologic diseases: antibodies to HTLV I Human T lymphotrophic virus type I may not be associated with multiple sclerosis in Japan Detection of human T-cell lymphoma virus type I DNA and antigen in spinal fluid and blood of patients with chronic progressive myelopathy Detection of coronavirus RNA and antigen in multiple sclerosis brain Bacterial toxin superantigens activate human T lymphocytes reactive with myelin autoantigens V-Beta specific stimulation of human T cells by staphylococcal toxins Findings in multiple sclerosis Problems of experimental trials of therapy in multiple sclerosis: report by the panel on evaluation of experimental trials of therapy in multiple sclerosis Influenza1 encephalopathy and post-influenza1 encephalitis Lyme disease: recommendations for diagnosis and treatment Human T-lymphocyte virus type I antibodies in the serum of patients with tropical spastic paraparesis in the Seychelles The diagnosis of childhood neurodegenerative disorders presenting as dementia in adults Textbook of child neurology Risk of developing multiple sclerosis after uncomplicated optic neuritis: a long-term prospective study Transverse myelitis: retrospective analysis of 33 cases, with differentiation of cases associated with multiple sclerosis and parainfectious events Long-term follow-up of acute partial transverse myelopathy Early risk of multiple sclerosis following isolated acute syndromes of the brainstem and spinal cord Prognostic significance of brain MRI at presentation with a clinically isolated syndrome suggestive of MS: a five-year follow-up study neuromyelitis optica and Schilder's myelinoclastic diffuse sclerosis Prognostic factors in a multiple sclerosis incidence cohort with twenty-five years of follow-up Multiple sclerosis: early prognostic guidelines Studies on the natural history of multiple sclerosis: eight early prognostic features of the later course of the illness Cardiovascular testing and exercise prescription in multiple sclerosis patients Multiple sclerosis.
     • keywords: abnormalities; activity; acute; administration; agents; antibodies; antigen; areas; autoimmune; azathioprine; baclofen; bands; basic; benefit; betaseron; bladder; blood; brain; brainstem; careful; cause; cell; central; cerebral; chronic; clinical; cns; cognitive; common; condition; control; copolymer; cord; correlate; course; criteria; csf; days; demyelination; depression; diagnosis; diazepam; disability; disease; dose; double; drug; dysfunction; early; effects; encephalomyelitis; environmental; episode; examination; exercise; experience; experimental; exposure; factors; fatigue; features; findings; fluid; follow; frequency; genetic; helpful; high; history; human; iii; images; imaging; important; infection; inflammation; inflammatory; interferon; intermittent; intravenous; investigations; january; known; lesions; level; long; low; lymphocytes; magnetic; matter; medications; methylprednisolone; mhc; mild; mri; multiple; multiple sclerosis; myelin; neuritis; neurologic; new; number; numbness; oligoclonal; onset; optic; oral; pain; paraparesis; pathogenesis; pathologic; patients; phase; physical; plaques; pregnancy; presence; present; primary; problems; progressive; protein; receptor; relapses; resonance; response; results; risk; sclerosis; severe; sign; spasms; spasticity; specific; spinal; steroid; studies; study; subacute; symptoms; syndrome; system; table; techniques; testing; therapy; time; transverse; treatment; tremor; trials; type; urinary; use; useful; vertigo; viral; virus; weakness; white; women; years
     • versions: original; plain text
106. cord-331557-8axi74nn
     • author: Raoult, Didier
     • title: What does the future hold for clinical microbiology?
     • date: 2004
     • words: 6513
     • flesch: 28
     • summary: key: cord-331557-8axi74nn authors: Raoult, Didier; Fournier, Pierre Edouard; Drancourt, Michel title: What does the future hold for clinical microbiology? date: 2004 journal: Nat Rev Microbiol DOI: 10.1038/nrmicro820 sha: doc_id: 331557 cord_uid: 8axi74nn In the past decade, clinical microbiology laboratories have undergone important changes with the introduction of molecular biology techniques and laboratory automation. Worldwide -mainly because of the cost of containment measures for infectious diseases -there has been a general tendency over the past 10 years to centralize clinical microbiology laboratories such that they serve several hospitals, therefore maximizing the efficiency of testing at the lowest cost 4 .
     • keywords: 16s; agents; amplification; analysis; antibiotic; antibodies; antigens; antimicrobial; application; approach; assays; availability; available; bacteria; bioterrorism; blood; cells; changes; clinical; clinical microbiology; complex; control; culture; databases; detection; development; diagnosis; different; digital; diseases; dna; electron; example; fcm; flow; future; gene; genome; hiv; human; identification; images; important; infected; infectious; isolates; laboratories; laboratory; large; mass; methods; microarrays; microbiology; microbiology laboratories; microorganisms; microscopy; molecular; new; non; number; particular; pathogens; patients; pcr; pictures; polymerase; possible; present; probes; products; protein; rapid; resistance; rickettsia; rna; rrna; samples; search; sequence; serum; spacer; specific; specimens; spectrometry; strategy; studies; susceptibility; systems; techniques; technology; testing; tests; time; tools; typing; universal; useful; viral; viruses
     • versions: original; plain text
107. cord-332078-vl309ss7
     • author: Cipollaro, Lucio
     • title: Musculoskeletal symptoms in SARS-CoV-2 (COVID-19) patients
     • date: 2020-05-18
     • words: 1422
     • flesch: -17
     • summary: Allergy Published Online First: 2 Clinical features and treatment of COVID-19 patients in northeast Chongqing Coronavirus disease 2019 in elderly patients: characteristics and prognostic factors based on 4-week follow-up Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China Clinical features and dynamics of viral load in imported and non-imported patients with COVID-19 Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Delivery of infection from asymptomatic carriers of COVID-19 in a familial cluster Risk factors associated with acute respiratory distress syndrome and death in patients with Coronavirus Disease Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis Clinical features of 85 fatal cases of COVID-19 from Wuhan: a retrospective observational study Clinical features of 69 cases with Coronavirus Disease Clinical characteristics of Coronavirus Disease 2019 in China Clinical characteristics of pregnant women with Covid-19 in Wuhan, China Clinical characteristics of non-critically ill patients with novel coronavirus infection (COVID-19) in a Fangcang Hospital Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection Epidemiological characteristics and clinical features of 32 critical and 67 noncritical cases of COVID-19 in Chengdu Epidemiological and initial clinical characteristics of patients with family aggregation of COVID-19 Clinical characteristics and outcomes of hospitalised patients with COVID-19 treated in Hubei (epicenter) and outside Hubei (non-epicenter): a nationwide analysis of China High-resolution chest CT features and clinical characteristics of patients infected with COVID-19 in Jiangsu, China Clinical characteristics of 25 death cases with COVID-19: a retrospective review of medical records in a single medical center Clinical characteristics of 54 medical staff with COVID-19: a retrospective study in a single center in Wuhan Multicenter analysis of clinical characteristics and outcome of COVID-19 patients with liver injury Rapid asymptomatic transmission of COVID-19 during the incubation period demonstrating strong infectivity in a cluster of youngsters aged 16-23 years outside Wuhan and characteristics of young patients with COVID-19: a prospective contact-tracing study Characteristics of COVID-19 infection in Beijing Clinical characteristics of Covid-19 in New York City Analysis of epidemiological and clinical features in older patients with Corona Virus Disease 2019 (COVID-19) out of Wuhan Clinical and CT features in pediatric patients with COVID-19 infection: different points from adults Relation between chest CT findings and clinical conditions of coronavirus disease (COVID-19) Pneumonia: A systematic review of COVID-19 epidemiology based on current evidence Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: a systematic review and meta-analysis Clinical value of immune-inflammatory parameters to assess the severity of coronavirus disease 2019 Symptom pathogenesis during acute influenza: interleukin-6 and other cytokine responses Rheumatologists' perspective on coronavirus disease 19 (COVID-19) and potential therapeutic targets Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures Clinical characteristics of older patients: the experience of a geriatric short-stay unit dedicated to patients with COVID-19 in France Clinical characteristics of laboratory confirmed positive cases of SARS-CoV-2 infection in Wuhan, China: A retrospective single center analysis Clinical features and short-term outcomes of 102 patients with Corona Virus Disease Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms Clinical characteristics of 161 cases of corona virus disease 2019 (COVID-19) in Changsha Clinical characteristics of 80 hospitalized frontline medical workers infected with COVID-19 in Wuhan Clinical characteristics and outcomes of older patients with coronavirus disease 2019 (COVID-19) in Wuhan, China (2019): a single-centered, retrospective study Clinical and autoimmune characteristics of severe and critical cases with COVID-19 Evaluation of SARS-CoV-2 RNA shedding in clinical specimens and clinical characteristics of 10 patients with COVID-19 in Macau Clinical features of patients infected with 2019 novel coronavirus in Wuhan Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings Clinical progression of patients with COVID-19 in Shanghai COVID-19 with different severity: a multi-center study of clinical features Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study COVID-19 in a designated infectious diseases hospital outside Hubei Province, China.
     • keywords: analysis; cases; center; characteristics; china; clinical; coronavirus; coronavirus disease; covid-19; disease; epidemiological; factors; features; findings; infection; inflammatory; musculoskeletal; novel; outcomes; outside; patients; pneumonia; retrospective; sars; single; study; symptoms; wuhan
     • versions: original; plain text
108. cord-333285-0s6dnm9i
     • author: Noonan, Devon
     • title: Navigating Nonessential Research Trials During COVID19: The Push We Needed For Using Digital Technology To Increase Access For Rural Participants?
     • date: 2020-04-13
     • words: 1082
     • flesch: 24
     • summary: Establishing remote access to clinical trials will serve to not only decrease rural clinical trial disparities, but also to promote rural health equity into the next decade and beyond. For example, universities could collaborate with satellite Internet cooperatives to increase access to rural broadband that would support a wide range of public health and clinical care initiatives beyond clinical trial research that would benefit rural areas.
     • keywords: access; activities; areas; barriers; cancer; care; clinical; covid-19; health; lack; need; participation; populations; recruitment; remote; research; researchers; residents; rural; strategies; study; trials
     • versions: original; plain text
109. cord-333340-ekok0mp5
     • author: Graf, Erin H.
     • title: Appropriate Use and Future Directions of Molecular Diagnostic Testing
     • date: 2020-02-06
     • words: 5779
     • flesch: 24
     • summary: Another randomized controlled trial found no difference in length of stay or antibiotic usage, including duration, comparing adult patients who received syndromic panel testing with those who received conventional microbiologic testing [16] . However, retrospective analyses have the benefit of knowing the final diagnosis while at the time of clinical presentation, it may have been appropriate to order syndromic panel testing [43] .
     • keywords: advances; analyses; analytical; antibiotic; antimicrobial; approach; appropriate; assay; authors; bacterial; blood; care; central; clinical; conventional; cost; csf; culture; data; detection; diagnosis; diarrhea; difficile; direct; disease; encephalitis; fda; filmarray; future; generation; hospital; hsv; human; identification; impact; implementation; infectious; influenza; interpretation; intervention; laboratory; length; limited; meningitis; metagenomics; molecular; multiplex; negative; new; panel; pathogen; patients; pcr; platforms; poc; point; positive; potential; rapid; resistance; respiratory; results; review; sample; sensitivity; sequencing; significant; single; speed; stay; stewardship; studies; study; syndromic; system; targets; testing; tests; time; tract; treatment; types; use; utility; utilization; viral; virus
     • versions: original; plain text
110. cord-333581-icp0xwhx
     • author: Aziz, Muhammad
     • title: Gastrointestinal predictors of severe COVID-19: systematic review and meta-analysis
     • date: 2020-07-30
     • words: 4314
     • flesch: 38
     • summary: Given the association of diarrhea with severe COVID-19 disease, based on our meta-analysis results, COVID-19 patients with diarrhea should be stratified into a high-risk group for developing severe disease as described above and managed accordingly. Articles were selected if they reported data on COVID-19 patients with respect to gastrointestinal symptoms (diarrhea, abdominal pain, and nausea/vomiting) or laboratory findings (serum AST, ALT, or TB).
     • keywords: admission; alt; america; analysis; bias; cases; characteristics; china; clinical; cohort; coronavirus; covid-19; data; diarrhea; disease; distress; elevated; et al; factors; features; fig; findings; gastrointestinal; group; infected; infection; laboratory; liver; manifestations; mean; meta; nausea; novel; outcomes; patients; pneumonia; prevalence; reported; respiratory; results; retrospective; review; risk; sars; search; serum; severe; severity; studies; study; symptoms; systematic; total; vomiting; wuhan
     • versions: original; plain text
111. cord-334433-oudvxb4d
     • author: Beane, Joal D.
     • title: Conducting Clinical Trials in the Time of a Pandemic
     • date: 2020-06-08
     • words: 1884
     • flesch: 41
     • summary: Responses to mitigate the effects of the pandemichave included: 1) thedevelopment of strategies to support research programs during unforeseen economic loss, 2)establishment of institutionalguidelines for clinical trials, 3)measures to ensure a healthy clinical research team, 4) useof innovative technologies to maintain access to clinical trials, 5) amendment of protocols to avoid costly trial closures, and 6) the strategic reopening of suspended clinical trials. key: cord-334433-oudvxb4d authors: Beane, Joal D.; Dedhia, Priya H.; Ejaz, Aslam; Contreras, Carlo M.; Cloyd, Jordan M.; Tsung, Allan; Pawlik, Timothy M. title: Conducting Clinical Trials in the Time of a Pandemic date: 2020-06-08 journal: Ann Surg DOI: 10.1097/sla.0000000000004114 sha: doc_id: 334433 cord_uid: oudvxb4d nan Mini Abstract: The novel human coronavirus (SARS-CoV-2) has created formidable challenges to the conduct of clinical trials and research.
     • keywords: addition; amendment; article; challenges; clinical; copyright; costly; covid-19; data; device; efforts; guidelines; health; important; inc; kluwer; pandemic; patients; protocol; reproduction; research; review; safety; staff; studies; team; telemedicine; trials; unauthorized; wolters
     • versions: original; plain text
112. cord-334773-yw2qgv13
     • author: Lisco, Giuseppe
     • title: Hypothesized mechanisms explaining poor prognosis in type 2 diabetes patients with COVID-19: a review
     • date: 2020-08-10
     • words: 7912
     • flesch: 27
     • summary: Unfortunately, inconclusive deductions are currently available for considering concomitant medications favourable (as well as detrimental) factors in COVID-19 patients with T2D. Despite some putative mechanisms have been identified and some speculative hypothesis have also been formulated indicating that some anti-diabetes medications may improve clinical course in COVID-19 (pioglitazone, gliflozins, DPP-IV inhibitors, GLP-1RA), further studies are needed to clarify the issue. Considering that pancreatic islets express ACE 2 , glucose impairment in COVID-19 diabetic patients could be attributable to a partial insulin deficiency
     • keywords: ace; ace2; activation; activity; acute; addition; adipose; analysis; angiotensin; animal; attributable; baseline; cardiovascular; care; case; cells; characteristics; china; chronic; clinical; comorbidities; complications; control; coronavirus; course; cov-2; covid-19; cytokine; data; death; diabetes; diabetic; disease; distress; dysfunction; effects; elderly; endothelial; epidemiological; expression; factor; failure; glucose; greater; heart; high; higher; hospitalization; hospitalized; human; hyperglycaemia; hypertension; ill; immune; increase; infected; infection; inflammation; inflammatory; injury; innate; insulin; intensive; kidney; leading; levels; like; low; lower; lung; management; mechanisms; medications; mellitus; mortality; novel; obese; obesity; outcomes; pandemic; patients; people; pneumonia; poor; potential; prevalence; prognosis; progression; pulmonary; rate; receptor; renal; respiratory; response; retrospective; review; risk; role; sars; severe; study; syndrome; system; systemic; t2d; tissue; transmission; treatment; type; use; viral; worse; wuhan
     • versions: original; plain text
113. cord-336554-n8n5ii5k
     • author: Singh, Thakur Uttam
     • title: Drug repurposing approach to fight COVID-19
     • date: 2020-09-05
     • words: 13068
     • flesch: 39
     • summary: Further, darunavir has been used (600 mg tablet every 12 h) along with other anti-viral drugs and supportive therapy in the clinical management of COVID-19 patients presented with a range of MEWS from less than 3 to more than 4 in Italy [33] . Hydroxychloroquine phosphate (400 mg tablet every 12 h as a loading dose followed 200 mg tablet every 12 h for 10 days) or chloroquine phosphate (250 mg of two tablet every 12 h for 10 days) along with other anti-viral drugs and supportive therapy have been used in the clinical management of COVID-19 patients presented with a range of MEWS from less than 3 to more than 4 in Italy
     • keywords: ace2; aceis; action; activity; acute; administration; adverse; agents; alpha; analysis; angiotensin; animal; antiviral; approach; approved; arbidol; arbs; arthritis; available; binding; bioavailability; body; broad; cardiovascular; case; cells; chemical; china; chronic; clinical; combination; common; computational; concentration; condition; coronavirus; cov2; covid-19; covid-19 patients; darunavir; data; day; days; dependent; development; dexamethasone; discovery; disease; dose; drug; east; ebola; effective; effects; efficacy; entry; enzyme; events; experimental; expression; failure; favipiravir; fda; fig; fusion; group; half; health; hepatitis; high; higher; hiv; host; https; human; hydroxychloroquine; ifnα-2b; il-6; improvement; infection; influenza; inhibition; inhibitors; interactions; interferon; intravenous; known; level; life; like; liver; long; lopinavir; low; lung; main; management; mechanisms; mers; metabolism; middle; mild; model; molecular; mortality; ncov; new; novel; number; old; oral; pathways; patients; peg; pharmacokinetics; phase; plasma; pneumonia; polymerase; potential; process; protease; protein; randomized; rate; rdrp; recent; receptor; recovery; reduction; related; remdesivir; renal; replication; repurposing; respiratory; response; results; review; rheumatoid; ribavirin; risk; ritonavir; rna; route; safety; sars; screening; severe; spectrum; spike; statins; studies; study; syndrome; table; targets; therapeutic; therapy; time; tocilizumab; toxicity; treatment; trial; use; vero; viral; viruses; vitro; vivo; year
     • versions: original; plain text
114. cord-336563-hwemigk7
     • author: Bhimraj, Adarsh
     • title: Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19
     • date: 2020-04-27
     • words: 8317
     • flesch: 36
     • summary: A Randomized Control Trial (THDMS-COVID19) High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection Compassionate Use of Remdesivir for Patients with Severe COVID-19 SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor Vascular and upper gastrointestinal effects of nonsteroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials Non-steroidal anti-inflammatory drug induced acute kidney injury in the community dwelling general population and people with chronic kidney disease: systematic review and meta-analysis Nonsteroidal antiinflammatory drugs may affect the presentation and course of community-acquired pneumonia Risks Related to the Use of Non-Steroidal Anti-Inflammatory Drugs in Community-Acquired Pneumonia in Adult and Pediatric Patients Efficacy of Addition of Naproxen in the Treatment of Critically Ill Patients Hospitalized for COVID-19 Infection (ENACOVID) HFSA/ACC/AHA statement addresses concerns re: using RAAS antagonists in COVID-19 Treating COVID-19-Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics Editorial Concern-Possible Reporting of the Same Patients With COVID-19 in Different Reports Steroid therapy and the risk of osteonecrosis in SARS patients: a dose-response meta-analysis The Ebola clinical trials: a precedent for research ethics in disasters Clinical research ethics for critically ill patients: a pandemic proposal Early observational research and registries during the 2009-2010 influenza A pandemic Choosing outcomes for clinical trials: a pragmatic perspective In an open label treatment trial, lopinavir-ritonavir with ribavirin reduced the mortality and requirement of intensive care support of hospitalized SARS patients compared with historical control
     • keywords: acute; additional; adverse; agents; antiviral; available; azithromycin; bias; c r; care; case; certainty; clearance; clinical; combination; concerns; context; control; convalescent; coronavirus; cov-2; covid-19; critical; data; determined; development; disease; drugs; effect; efficacy; events; evidence; failure; findings; grade; group; guideline; hcq; health; high; hospital; hydroxychloroquine; idsa; illness; important; imprecision; improvement; infection; inhibitors; limited; literature; lopinavir; low; management; members; mers; mortality; n u; need; non; nsaids; observational; outcomes; p t; panel; patients; plasma; pneumonia; potential; process; prolongation; questions; randomized; rapid; rate; rcts; recommendations; remdesivir; research; respiratory; review; risk; ritonavir; s c; safety; sars; severe; studies; study; support; systematic; table; therapeutic; tocilizumab; treatment; trials; u s; use; viral; virologic
     • versions: original; plain text
115. cord-340028-6oicmeam
     • author: Zhavoronkov, Alex
     • title: Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections
     • date: 2020-03-31
     • words: 7232
     • flesch: 30
     • summary: However, it may be possible to conduct clinical trials on the efficacy of geroprotectors previously tested in human clinical trials in treating COVID-19 and other gerophilic and gerolavic infections. Substantial pre-clinical validation would be required to apply these compounds to specific age-associated diseases and to explore clinical applications of these compounds in human clinical trials.
     • keywords: additional; age; agents; aging; analysis; antiviral; article; associated; available; benefit; biological; biomarkers; burden; cancer; cells; china; clinical; clinical trials; clocks; combination; compounds; coronavirus; cov-2; covid-19; data; death; decrease; deep; development; different; disease; drugs; effective; effects; efficacy; elderly; everolimus; evidence; function; gerolavic; gerophilic; geroprotective; geroprotectors; global; human; immune; immunosenescence; increase; individuals; infection; influenza; inhibitors; interventions; lethality; levels; lifespan; like; major; medical; medicine; metformin; mice; multiple; nad; new; nicotinamide; older; pandemic; patients; population; possible; potential; prevention; rad001; rapalogs; rapamycin; rates; research; respiratory; response; riboside; risk; role; sars; season; senolytics; senoremediative; severe; severity; sirolimus; specific; strategies; studies; study; substantial; supplementation; symptom; targeting; thymus; treatment; treg; trials; use; vaccination; vaccine; validation; viral; years
     • versions: original; plain text
116. cord-340415-6fte7krp
     • author: Thevarajan, Irani
     • title: Clinical presentation and management of COVID‐19
     • date: 2020-07-17
     • words: 4292
     • flesch: 36
     • summary: The majority of patients presenting with coronavirus disease 2019 (COVID‐19) experience a mild illness that can usually be managed in the community. Patients require careful monitoring and early referral to hospital if any signs of clinical deterioration occur.
     • keywords: able; acute; admission; agents; appropriate; associated; asymptomatic; care; cases; characteristics; china; clinical; community; comorbidities; complications; context; coronavirus; cov-2; covid-19; days; disease; early; evidence; features; guidelines; health; high; hospital; hydroxychloroquine; illness; infected; infection; interim; lopinavir; management; median; monitoring; mortality; need; novel; outcomes; oxygen; pandemic; patients; people; pneumonia; positive; possible; potential; present; randomised; rate; respiratory; risk; ritonavir; sars; severe; specific; symptoms; syndrome; therapy; time; treatment; trials; use; ventilation; viral; wuhan; years
     • versions: original; plain text
117. cord-340656-ltd6ueoi
     • author: Grant, Michael C.
     • title: The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries
     • date: 2020-06-23
     • words: 3443
     • flesch: 38
     • summary: Analysis of clinical symptoms in adult patients Clinical and Laboratory Profiles of 75 Hospitalized Patients with Novel Coronavirus Disease Clinical features and outcomes of 197 adult discharged patients with COIVD-19 in Yichang Optimizing diagnostic strategy for novel coronavirus pneumonia The necessity to address deficiencies in current literature and potential to substantially improve the precision of estimates of symptom prevalence using both indexed and (the more voluminous and up-to-date) preprint literature from multiple geographical regions, represents the rational for this review.
     • keywords: a1111111111; adults; analysis; articles; authors; bias; biorxiv; cases; characteristics; china; clinical; coronavirus; cough; countries; cov-2; covid-19; data; disease; early; epidemiological; estimates; features; fever; findings; heterogeneity; hospital; infected; infection; laboratory; likely; medrxiv; meta; non; novel; outcomes; patients; pneumonia; prevalence; retrospective; review; risk; sars; severe; single; studies; study; symptoms; test; wuhan
     • versions: original; plain text
118. cord-341801-n11ilz6l
     • author: Wintraub, Lauren
     • title: Wearable technology and live video conferencing: The development of an affordable virtual teaching platform to enhance clinical skills education during the COVID-19 pandemic
     • date: 2020-09-23
     • words: 1176
     • flesch: 38
     • summary: key: cord-341801-n11ilz6l authors: Wintraub, Lauren; Xie, Mary; Issa, Mariam; Jeyakumar, Yaanu; Nelms, Matthew; Sharma, Deepanshu; Teitelbaum, Daniel; Otremba, Mirek; Sirianni, Giovanna; Nyhof-Young, Joyce; Leung, Fok-Han title: Wearable technology and live video conferencing: The development of an affordable virtual teaching platform to enhance clinical skills education during the COVID-19 pandemic date: 2020-09-23 journal: Can Med Educ J DOI: 10.36834/cmej.70554 sha: doc_id: 341801 cord_uid: n11ilz6l nan The novel coronavirus disease 2019 (COVID-19) pandemic has forced physical distancing, compelling most medical programs to move their entire preclerkship curricula online. These exams are central to undergraduate clinical skills education and have notable shortcomings in traditional pre-recorded learning aids (e.g. poor visualization of physical exam maneuvers).
     • keywords: accessory; chest; clinical; conferencing; covid-19; device; education; exam; group; learning; medical; online; pandemic; physical; platform; pre; skills; students; teaching; technology; use; video; wearable; zoom
     • versions: original; plain text
119. cord-342756-rgm9ffpk
     • author: Senger, Mario Roberto
     • title: COVID-19: molecular targets, drug repurposing and new avenues for drug discovery
     • date: 2020-10-02
     • words: 16157
     • flesch: 39
     • summary: Structure-based virtual screening and molecular dynamics simulation of SARS-CoV-2 Guanine-N7 methyltransferase (nsp14) for identifying antiviral inhibitors against COVID-19 Virtual screening, ADME/T, and binding free energy analysis of anti-viral, anti-protease, and anti-infectious compounds against NSP10/ NSP16 methyltransferase and main protease of SARS CoV-2 Targeting SARS-COV-2 non-structural protein 16: a virtual drug repurposing study Ready, set, fuse! (148) Other targets -Apart from SARS-CoVs infection, some relevant molecular targets of other viral diseases and host metabolism have also been investigated in COVID-19 drug discovery, such as viral neuraminidases and the DPP4 cell receptor.
     • keywords: abbott; ace2; acid; activities; activity; acute; addition; analysis; angiotensin; animal; antiviral; approaches; associated; authors; available; baricitinib; beta; binding; blind; broad; cathepsin; cells; cellular; chemical; china; chloroquine; cleavage; clinical; combination; company; compounds; computational; confirmation; coronavirus; cost; cov-2; covid-19; covid-19 treatment; covs; cycle; cytoplasm; data; days; deep; dependent; development; diabetes; different; discovery; disease; docking; domain; double; dpp4; drug; early; effectiveness; effects; efficacy; entry; envelope; enzyme; essential; expression; family; fda; fig; final; form; function; fusion; gilead; glycoprotein; graph; grna; group; hcq; health; helicase; high; host; human; hydrolysis; hydroxychloroquine; il-6; immune; important; infected; infection; inflammatory; influenza; information; inhibition; inhibitors; interaction; intermediate; kda; key; knowledge; large; learning; like; lopinavir; lower; mechanism; membrane; mers; methods; methyltransferase; models; molecular; molecules; natural; ncov; need; network; new; non; novel; nsp14; number; options; overall; pandemic; patent; pathogenesis; pathway; patients; phase; plasma; pneumonia; polymerase; polyproteins; possible; post; potential; pp1ab; process; production; promising; protease; protein; randomised; rdrp; reaction; recent; receptor; related; release; remdesivir; replication; repurposing; research; respiratory; response; responsible; results; review; risk; ritonavir; rna; role; safety; sars; sars coronavirus; severe; similar; site; small; spectrum; spike; steps; strategies; strategy; structure; studies; study; syndrome; synthesis; synthetic; system; target; terminal; therapeutic; time; tmprss2; transmembrane; treatment; trials; type; use; viral; virion; viruses; vivo; wuhan; yield
     • versions: original; plain text
120. cord-343715-y594iewi
     • author: Gavriatopoulou, Maria
     • title: Organ-specific manifestations of COVID-19 infection
     • date: 2020-07-27
     • words: 8776
     • flesch: 34
     • summary: Cerebrovascular disease represents another mechanism explaining neurological signs and symptoms in COVID-19 patients, although the rate of acute stroke admissions has been significantly reduced over the COVID-19 pandemic [125] . Among COVID-19 patients who suffered a stroke, the rate of cryptogenic and embolic strokes was higher, and events were more severe and affected younger patients [126, 129] .
     • keywords: abnormalities; ace2; acute; alveolar; analysis; angiotensin; ards; arrhythmias; associated; binding; blood; brain; cardiovascular; cases; cells; characteristics; chest; china; clinical; common; comorbidities; complications; coronavirus; coronavirus disease; cortisol; course; cov-2; covid-19; covid-19 patients; cytokine; damage; data; days; death; diarrhoea; different; digestive; direct; disease; distress; dysfunction; early; effect; endothelial; expression; failure; features; findings; gastrointestinal; heart; high; higher; hospitalized; host; hypoxia; ill; immune; increase; infected; infection; inflammation; inflammatory; injury; involvement; kidney; levels; liver; low; lung; manifestations; mechanisms; meta; mild; moderate; mortality; myocardial; myocarditis; nervous; neurological; non; novel; olfactory; organ; outcomes; pandemic; patients; pneumonia; poor; presentation; prevalence; pulmonary; recent; receptors; reported; respiratory; response; results; retrospective; review; risk; rna; role; sars; series; severe; severity; single; specific; storm; stroke; studies; study; symptoms; syndrome; system; systemic; time; tissue; tract; treatment; tropism; type; underlying; viral; wuhan
     • versions: original; plain text
121. cord-344705-co0nk7pt
     • author: Eichler, Hans‐Georg
     • title: Clinical trials for Covid‐19: can we better use the short window of opportunity?
     • date: 2020-05-14
     • words: 2990
     • flesch: 38
     • summary: key: cord-344705-co0nk7pt authors: Eichler, Hans‐Georg; Cavaleri, Marco; Enzmann, Harald; Scotti, Francesca; Sepodes, Bruno; Sweeney, Fergus; Vamvakas, Spiros; Rasi, Guido title: Clinical trials for Covid‐19: can we better use the short window of opportunity? date: 2020-05-14 journal: Clin Pharmacol Ther DOI: 10.1002/cpt.1891 sha: doc_id: 344705 cord_uid: co0nk7pt This is not surprising; in the context of epidemics, academic groups, public health authorities, and funding bodies generally step up in their contribution to the crisis including design and conduction of clinical trials.
     • keywords: academic; article; authorities; clinical; community; conduct; coordination; copyright; covid-19; development; disease; drug; early; ema; established; european; health; high; interventions; large; level; mechanisms; national; need; opportunity; pandemic; patients; plan; platform; public; rapid; regulatory; research; researchers; reserved; results; rights; scientific; severe; single; small; studies; subjects; support; treatment; trials; use; vaccines
     • versions: original; plain text
122. cord-345371-pjbviagq
     • author: Lisi, Lucia
     • title: Approaching Coronavirus Disease 2019: mechanisms of action of repurposed drugs with potential activity against SARS-CoV-2
     • date: 2020-07-23
     • words: 10674
     • flesch: 18
     • summary: Among them, the international Solidarity trial launched by the WHO on March 2020 with the aim to find an effective treatment for COVID-19 patients by comparing four different treatments (i.e., lopinavir/ritonavir, lopinavir/ritonavir plus interferon-β, chloroquine/hydroxychloroquine or remdesivir) against standard of care (see also sections 2 and 3). Besides exerting potential direct antiviral effects, baricitinib might prevent the dysregulated production of pro-inflammatory cytokines typically observed in COVID-19 patients via the inactivation of interleukin-6 (IL6)-JAK-signal transducer and activator of transcription (STAT) pathway (this activity will be more deeply discussed in section 3, especially regarding the JAK inhibitor ruxolitinib).
     • keywords: able; ace2; activation; activity; acute; agents; anakinra; analysis; angiotensin; antiviral; ards; associated; azithromycin; baricitinib; benefit; binding; cardiovascular; care; case; cells; china; clinical; coagulation; cohort; combination; compassionate; complications; control; converting; coronavirus; cov-2; covid-19; covid-19 patients; cytokine; damage; data; days; dependent; different; disease; distress; dose; drugs; early; effective; effects; efficacy; endothelial; entry; enzyme; epithelial; failure; fibrinolytic; fingolimod; fusion; group; heart; heparin; high; host; human; hydroxychloroquine; icu; il6; ill; immune; improvement; infected; infection; inflammation; inflammatory; inhibition; inhibitors; injury; interaction; interferon; levels; like; lopinavir; low; lung; mechanisms; membrane; mers; mesenchymal; molecule; mortality; multiple; nafamostat; new; non; novel; number; oral; patients; pharmacological; pneumonia; polymerase; potential; production; protease; protein; pulmonary; randomized; receptor; related; release; remdesivir; replication; reported; respiratory; response; results; retrospective; review; risk; ritonavir; rna; role; safety; sars; sclerosis; severe; severe covid-19; single; small; storm; studies; study; symptoms; syndrome; system; target; targeting; therapeutic; therapy; tocilizumab; transmission; treatment; trials; type; umifenovir; use; vegf; viral; viruses
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123. cord-346539-kxnrf5g5
     • author: Riggioni, Carmen
     • title: A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2
     • date: 2020-06-14
     • words: 15806
     • flesch: 41
     • summary: All rights reserved hypersensitivity reactions to drugs may occur more often during the pandemic due to the increased use of drugs and drug interactions, which can result in morbilliform rash, erythroderma, Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia Effect of changing case definitions for COVID-19 on the epidemic curve and transmission parameters in mainland China: a modelling study Presumed Asymptomatic Carrier Transmission of COVID-19 Eleven faces of coronavirus disease 2019 The proximal origin of SARS-CoV-2 Phylogenetic network analysis of SARS-CoV-2 genomes Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2 SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor Distribution of ACE2, CD147, cyclophilins, CD26 and other SARS-CoV-2 associated molecules in various human tissues and immune cells in health and disease SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses Distribution of ACE2, CD147, CD26 and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes The potential danger of suboptimal antibody responses in COVID-19 Resistance to coronavirus infection in amino peptidase N-deficient pigs Mammalian Glutamyl Aminopeptidase Genes (ENPEP) and Proteins: Comparative Studies of a Major Contributor to Arterial Hypertension Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26 ACE1 polymorphism and progression of SARS Longitudinal profile of antibodies against SARS-coronavirus in SARS patients and their clinical significance Antibody responses to SARS-CoV-2 in patients with COVID-19 Long-term coexistence of SARS-CoV-2 with antibody response in COVID-19 patients Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients The Multifaceted B Cell Response in Allergen Immunotherapy COVID-19 Autopsies EAACI position paper on how to classify cutaneous manifestations of drug hypersensitivity Lung eosinophils-A novel virus sink that is defective in asthma? On the other hand, a retrospective study on SARS patients in Hong Kong suggested a better survival rate in patients treated with prednisolone for milder pneumonia or methylprednisolone in more severe cases.
     • keywords: ace2; activation; acute; addition; adults; ait; allergic; allergy; analysis; antibodies; antibody; antiviral; ards; article; associated; asthma; asthmatic; asymptomatic; atopic; available; azithromycin; barrier; bcg; care; cases; cd147; cd4; cells; change; characteristics; children; china; clinical; common; contact; control; convalescent; copyright; coronavirus; corticosteroids; countries; country; counts; cov-2; covid-19; covid-19 pandemic; covid-19 patients; css; current; cytokine; data; date; days; deaths; dermatitis; detection; development; diagnosis; different; disease; distancing; dose; drug; dupilumab; early; effect; effective; eosinophil; epidemic; epithelial; evidence; example; exposure; expression; face; factor; features; fever; figure; gene; general; hand; health; healthcare; high; higher; human; hydroxychloroquine; ifn; iga; ill; illness; immune; immunity; impact; important; individuals; infected; infection; inflammation; inhibitors; initial; innate; international; isolation; levels; likely; low; lower; lung; lymphopenia; management; manifestations; measures; mechanisms; mers; mild; mortality; nasal; natural; need; negative; non; novel; number; obesity; observational; onset; outbreak; outcomes; pandemic; patients; pcr; phase; plasma; pneumonia; population; positive; possible; post; potential; primary; progression; protection; protein; randomized; receptor; reduction; related; remdesivir; research; reserved; respiratory; responses; results; review; rhinitis; rights; risk; rna; role; safety; samples; sars; seroconversion; serum; severe; severe covid-19; severity; shedding; single; skin; small; social; specific; spike; spread; studies; study; susceptibility; symptoms; syndrome; systemic; testing; tests; therapy; time; tmprss2; tocilizumab; tract; transmission; treatment; trials; type; unknown; use; vaccination; vaccine; viral; viruses; week; wuhan; years
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124. cord-347189-i9rzo3j0
     • author: Lorusso, Domenica
     • title: Clinical research disruption in the post-COVID-19 era: will the pandemic lead to change?
     • date: 2020-10-13
     • words: 3313
     • flesch: 33
     • summary: Moreover, less than 5% of cancer clinical trials adequately accrue ethnic minorities (OR 0.7 with respect to white patients in cancer clinical trials) 10 and a potential explanation is that travel burden to centres mandated by specific trials (eg, rare cancers) implies time off from work and family commitments for both patients and careers leading to financial repercussions. The effect of telehealth interventions on quality of life of cancer patients: a systematic review and meta-analysis Participation in cancer clinical trials: race-, sex-, and age-based disparities At what cost to clinical trial enrollment?
     • keywords: access; activities; approval; cancer; care; centres; challenges; changes; clinical; clinical research; clinical trials; community; contract; cost; covid-19; covid-19 pandemic; data; days; drug; electronic; era; face; global; health; implementation; important; international; local; median; medical; monitoring; national; new; pandemic; participation; patients; person; phase; procedures; process; quality; remote; research; review; safety; scientific; sharing; site; study; telemedicine; tests; time; tomorrow; trial; visits; work; world
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125. cord-348137-dzmbfp2g
     • author: Bi, Qifang
     • title: Characterization of clinical progression of COVID-19 patients in Shenzhen, China
     • date: 2020-04-27
     • words: 4554
     • flesch: 43
     • summary: Using data from Shenzhen, China, where all cases were monitored in hospital and symptom profiles and clinical and lab results were available starting from early stages of clinical course, we characterized clinical progression of COVID-19 cases and determined important predictors for faster clinical progression to key clinical events and longer use of medical resources. We estimate time from symptom onset to key clinical events, such as first clinical diagnosis, progression to severe clinical stages, development of acute respiratory distress syndrome (ARDS), admission to the critical care unit (ICU), and discharge.
     • keywords: 95%ci; admission; april; ards; available; average; cases; characteristics; clinical; covid-19; critical; cumulative; data; date; days; discharge; duration; events; faster; figure; group; hospital; icu; incidence; initial; license; low; males; medical; medrxiv; mild; moderate; onset; patients; preprint; progression; results; risk; severe; severity; shenzhen; stage; symptom; table; time; use; ventilator; version
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126. cord-348244-1py0k53e
     • author: Buyse, Marc
     • title: Central statistical monitoring of investigator-led clinical trials in oncology
     • date: 2020-06-23
     • words: 4053
     • flesch: 37
     • summary: A Risk-Based Approach to Monitoring Data-driven risk identification in phase III clinical trials using central statistical monitoring Available at https ://trans celer atebi ophar mainc .com/asset s/rbm-asset s/ (Accessed 14 A statistical approach to central monitoring of data quality in clinical trials Linear mixed-effects models for central statistical monitoring of multicenter clinical trials Use of the betabinomial model for central statistical monitoring of multicenter clinical trials A hercule poirot of clinical research Detection of atypical data in multicenter clinical trials using unsupervised statistical monitoring Statistical monitoring of data quality and consistency in the Stomach Cancer Adjuvant Multi-institutional The control of the false discovery rate in multiple testing under dependency Sequential paclitaxel followed by tegafur and uracil (UFT) or S-1 vs. UFT or S-1 monotherapy as adjuvant chemotherapy for T4a/b gastric cancer (SAMIT): a phase 3 factorial randomised controlled trial Fraud in clinical trials The role of biostatistics in the prevention, detection and treatment of fraud in clinical trials Guidance for industry, investigators, and institutional review boards. The contribution of clinical trials to the overall costs of drug development is not known with precision, but recent estimates suggest that pivotal clinical trials leading to FDA approval have a median cost of US$ 19 million; such costs are even higher in oncology and cardiovascular medicine, as well as in trials with a long-term clinical outcome, such as survival
     • keywords: agencies; approach; approval; assessment; cancer; centers; central; clinical; clinical trials; cost; csm; data; drug; errors; evidence; fig; focus; impact; important; industry; investigator; issues; key; large; management; monitoring; multicenter; new; oncology; paper; patients; practice; pragmatic; quality; randomized; research; results; risk; safety; site; source; statistical; study; tests; time; treatment; trials; types; use; verification; visits
     • versions: original; plain text
127. cord-349210-8t4a5qqo
     • author: Ji, Ping
     • title: Immunomodulatory Therapeutic Proteins in COVID‐19: Current Clinical Development and Clinical Pharmacology Considerations
     • date: 2020-08-10
     • words: 7716
     • flesch: 34
     • summary: About 5-10% of COVID-19 patients developed lung injury and respiratory distress that progressed to acute respiratory distress syndrome (ARDS). A minority of COVID-19 patients will transition into the severe and critical stages of the illness, which manifest as an extrapulmonary systemic hyperinflammation syndrome.
     • keywords: activation; acute; anakinra; analysis; anti; antibodies; antibody; ards; article; associated; benefit; biologics; care; cell; china; clinical; control; copyright; coronavirus; cov-2; covid-19; covid-19 patients; critical; cytokine; daily; data; days; development; disease; distress; dose; dosing; drug; efficacy; elevated; experience; expression; factor; fda; group; higher; il-6; illness; immune; immunomodulatory; infected; infection; inflammation; inflammatory; inhibitor; injury; innate; levels; lung; management; moderate; monoclonal; multiple; novel; pandemic; pathway; patients; pharmacology; phase; pneumonia; potential; prevention; proteins; randomized; regimen; respiratory; response; retrospective; review; rights; risk; role; route; safety; sars; secondary; severe; severity; single; stages; study; symptoms; syndrome; system; therapeutic; therapies; therapy; tissue; tnf; tocilizumab; treatment; trial; use; viral; week; wuhan
     • versions: original; plain text
128. cord-350571-6tapkjb6
     • author: None
     • title: 45th ESCP-NSF international symposium on clinical pharmacy: clinical pharmacy tackling inequalities and access to health care. Oslo, Norway, 5–7 October 2016
     • date: 2017-01-10
     • words: 106086
     • flesch: 45
     • summary: Clinical pharmacists have a role to evaluate and optimize the appropriateness and effectiveness of patient's medications. DTSIs interventions (treatment group) consist in: motivational interview, sharing and delivery of printed, explanatory material in the patient's native language, reconciliation of patients medications at hospital admission and at discharge; identification of potential risks due to drug-drug interactions; monitoring of compliance to drug therapy, and finally detection of adverse drug reactions (ADRs) occurring in the course of care.
     • keywords: 0.001; 1st; absence; abstract background; abstract type; acceptance; access; account; active; activities; activity; acute; adapted; addition; adherence; adherent; adjusted; adjustment; administration; admission; adolescents; adrs; adult patients; adults; adverse; adverse drug; advice; affected; age; aged; agency; agents; aim; ambulatory; amphotericin; analysed; analysis; anne; antibiotics; anticholinergic; anticoagulants; anticoagulation; antihypertensive; antimicrobial; antiplatelet; antipsychotics; apixaban; application; approach; approval; april; areas; articles; assessment; associated; association; audit; available; average; awareness; barriers; baseline; beds; beliefs; benefit; benzodiazepines; best; better; biosimilar; bleeding; blood; bmq; broad; burden; bzd; calcium; cancer; cancer patients; cardiac; cardiology; cardiovascular; care; cases; cause; cd4; cell; central; centre; changes; characteristics; check; chemotherapy; children; chlormethine; choice; chosen; chronic; classes; clearance; clinical; clinical impact; clinical pharmacist; clinical practice; clinical response; clinicians; close; cognitive; cohort; collaboration; collection; combination; committee; common; communication; community; community pharmacy; complete; complexity; compliance; complications; concentrations; concerned; conclusion; concomitant; conditions; consequences; consisted; consumption; contact; context; continuous; contribution; control; copd; correct; correlation; cost; counselling; countries; country; course; creatinine; criteria; critical; cross; current; daily; daptomycin; data; database; date; day; days; dbi; december; decreased; degree; delirium; delivery; demographic; department; depression; descriptive abstract; descriptive study; design; detection; development; device; diabetes; diabetic; diagnosis; differences; different; digestive; digoxin; direct; discharge; discontinuation; discrepancies; discrepancy; discussion; disease; disorders; dispensation; dispensing; distribution; doctors; documented; dosage; dose; dosing; drps; drug; drug background; drug interactions; drug prescription; drug therapy; drug treatment; drug use; drv; duration; e.g.; early; economic; educational; effectiveness; effects; efficacy; efficiency; elderly patients; electronic; eligible; emergency; errors; essential; establishment; european; evaluated; evaluation; events; evidence; excel; expected; experience; exposure; eye; face; factors; failure; february; female; fibrosis; findings; focus; following; formulary; formulation; fragile patients; framework; france; french; frequency; frequent; function; future; gastrointestinal; gel; gender; general; genetic; genotype; geriatric; good; greater; group; guidance; guidelines; haemodialysis; half; hcv; head; health; health care; healthcare; help; hepatic; herbal; high; higher; highest; history; hiv; home; home medication; home patients; hospital; hospital medication; hospital pharmacy; hospitalization; hospitalized; hypertension; iatrogenic; ibd; icu; identification; ids; impact; impairment; implementation; implemented; important; improved; improvement; inappropriate; increase; index; indicated; indications; individual; infected; infection; infective; inflammatory; infliximab; influence; influenza; information; informed; infusion; inhibitors; initial; insulin; integrated; intensive; interactions; interdisciplinary; internal; international; interventions; interview; intravenous; introduction; involved; issues; items; january; july; june; key; kidney; knowledge; known; label; laboratory; lack; large; later; lead; learning; level; life; like; likely; limited; liquid; list; literature; liver; loading; local; long; longer; lower; lung; main; main objective; main outcome; maintenance; major; majority; males; management; march; market; marketing; maximum; mdd; mds; mean; measures; median; medical; medical treatment; medication; medication adherence; medication changes; medication data; medication discrepancies; medication errors; medication history; medication information; medication knowledge; medication lists; medication management; medication reconciliation; medication review; medication safety; medication use; medicines; medium; meeting; melatonin; member; mentioned; metastatic; methadone; method; methodology; metoclopramide; mmol; model; moderate; modified; monitoring; monotherapy; months; morbidity; mortality; mrps; multidisciplinary; multiple; mur; n =; national; nausea; necessary; necessity; need; negative; neurology; new; nintedanib; noacs; non; norway; norwegian; notes; november; nsaids; number; nurses; nursing; objective; observational; observational study; old; omission; oncology; online; operating; optimal; optimization; oral; order; organization; original; oslo; outcome; outcome measures; outpatient; overall; p =; paediatric; pain; parameters; paris; partial; participants; participation; particular; patient adherence; patient care; patient education; patient safety; patients; pcz; people; percentage; period; pharmaceutical; pharmaceutical care; pharmacist intervention; pharmacists; pharmacokinetic; pharmacotherapy; pharmacy; pharmacy service; phase; phosphorus; physical; physicians; pill; pilot; pilot study; pims; pip; pirfenidone; place; plasma; plus; points; polypharmacy; poor; population; posaconazole; positive; possible; post; potential; potential medication; ppis; practical; practice; practitioners; pregnancy; preparation; prescribed; prescribing; prescription; presence; present; pressure; prevalence; prevention; previous; primary; primary care; prior; problems; procedure; process; products; professionals; profile; program; projects; proper; proportion; prospective; prospective study; protocol; psychiatric; psychotropic; public; purpose; qol; qualitative; quality; questionnaire; questions; range; rate; reactions; reasons; recent; recommendations; recorded; records; reduced; reduction; reference; regimen; regional; regorafenib; regular; related; relationship; relevance; relevant; relief; renal; repackaged; report; reporting; research abstract; residents; resistance; respiratory; respondents; response; responsibility; responsible; results; retrospective; review; ribavirin; risk; risk patients; ritonavir; role; safety; sample; satisfaction; satisfied; scale; score; screening; second; secondary; sedative; self; semi; september; serum; service; sessions; setting; severe; severity; sex; short; significant; single; sites; situation; skills; skin; slovenia; social; society; sofosbuvir; software; solid; solutions; sources; specialty; specific; spss; staff; standard; standardized; start; state; statistical; status; stay; step; stock; stopp; storage; strategies; strategy; structured; students; studies; study; study group; study period; subjects; sufficient; summary; supply; support; surgery; surgical; survey; svr; switch; symptoms; syndrome; system; systematic; t =; tablets; taking; targeted; tasks; tdm; team; term; tertiary; test; themes; therapeutic; therapies; therapy; time; tool; total; training; transfer; transition; transplant; transplant patients; transplantation; treatment; treatment adherence; trials; trough; trp; types; unintentional; units; university; university hospital; urinary; use; useful; users; usual; utility; validation; valproate; value; vancomycin; variables; viral; voriconazole; vs.; ward; warfarin; weeks; weight; women; work; working; world; wpme; wrong; years
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129. cord-350793-bftztg0e
     • author: Nizami, Shermeen
     • title: Implementation of Artifact Detection in Critical Care: A Methodological Review
     • date: 2018-04-30
     • words: 7223
     • flesch: 37
     • summary: This shall promote (a) reusability of algorithms across different CCU domains; (b) evaluation on different OEM monitor data; (c) fair comparison through formalised SQIs; (d) meaningful integration with other AD, CED and PD algorithms; and (e) real-time implementation in clinical workflows. This limits their use with different OEM monitor data.
     • keywords: alarms; algorithms; analysis; apnea; approach; artifact; automatic; blood; care; ccu; ced; centric; characteristics; clinical; comparison; condition; continuous; criteria; critical; data; decision; detection; development; different; domain; early; ecg; estimation; evaluation; event; example; false; fig; framework; frequency; fusion; generation; groups; heart; icu; identification; implementation; independent; infants; information; input; integration; intensive; masimo; medical; methodological; metrics; models; monitored; monitoring; monitors; multiple; multivariate; neonatal; new; novel; oem; output; oxygen; parameter; patient; performance; philips; physiologic; pressure; processing; publications; pulse; quality; rate; real; research; respiratory; results; review; robust; section; sepsis; set; signal; sleep; specific; spo; sqis; standalone; stream; studies; study; support; system; table; taxonomy; techniques; technology; theme; time; tool; types; unit; usa; use; value; variability; workflows
     • versions: original; plain text
130. cord-352177-05sku8a8
     • author: Pahus, Laurie
     • title: Patient distrust in pharmaceutical companies: an explanation for women under-representation in respiratory clinical trials?
     • date: 2020-08-13
     • words: 4118
     • flesch: 31
     • summary: Specifically, we sought to evaluate if distrust in pharmaceutical companies and associated psychosocial factors could represent a recruitment bias in clinical trials and thus threaten the applicability of their results. The recruitment and retention of patients in clinical trials is challenging, but necessary, because it is the cornerstone of medical evidence production.
     • keywords: access; age; approval; associated; bias; categories; chronic; clinical; clinical trials; companies; consent; different; disease; distrust; drug; employment; ethics; factors; french; group; health; healthcare; inactive; industry; knowledge; level; marketing; media; medical; membership; new; participate; participation; patients; pharmaceutical; pharmaceutical companies; physicians; poor; potential; pre; private; profile; public; questionnaire; rates; recruitment; refusal; research; respiratory; results; specific; studies; study; survey; trials; variables; willingness; women
     • versions: original; plain text
131. cord-353330-j00jj2og
     • author: Rej, Robert
     • title: Clinical Chemistry through Clinical Chemistry: A Journal Timeline
     • date: 2004-12-01
     • words: 5659
     • flesch: 53
     • summary: key: cord-353330-j00jj2og authors: Rej, Robert title: Clinical Chemistry through Clinical Chemistry: A Journal Timeline date: 2004-12-01 journal: Clin Chem DOI: 10.1373/clinchem.2004.042820 sha: doc_id: 353330 cord_uid: j00jj2og The establishment of the modern discipline of clinical chemistry was concurrent with the foundation of the journal Clinical Chemistry and that of the American Association for Clinical Chemistry in the late 1940s and early 1950s. Clin Chem 1957;
     • keywords: aacc; abstracts; access; accuracy; acute; advances; analyses; analytical; antibody; applications; articles; assays; authors; automation; available; calcium; cardiac; chem; chemistry; chromatography; citation; clin; clin chem; clinical; clinical chemistry; computer; conference; content; countries; current; data; day; days; decades; detection; determination; development; diagnostics; dna; editor; electronic; enzyme; field; future; general; high; history; immunoassay; information; instruments; iodine; journal; king; laboratories; laboratory; large; line; major; measurement; medicine; method; new; pages; papers; patients; period; president; profession; protein; quality; rapid; rate; reaction; readers; reference; report; results; review; role; samples; science; scientific; screening; serum; specific; standardization; study; system; time; today; topics; troponin; urea; use; useful; variability; volume; way; work; world; years
     • versions: original; plain text
132. cord-353528-8a3f5hxu
     • author: Levy, Oren
     • title: Shattering barriers toward clinically meaningful MSC therapies
     • date: 2020-07-22
     • words: 13111
     • flesch: 24
     • summary: Safety of cell therapy with mesenchymal stromal cells (SafeCell): A systematic review and meta-analysis of clinical trials Effective treatment of steroid and therapy-refractory acute graft-versushost disease with a novel mesenchymal stromal cell product (MSC-FFM) Safety of repeated transplantations of neurotrophic factors-secreting human mesenchymal stromal stem cells Plasticity of mesenchymal stem cells in immunomodulation: K.S. has been a consultant for stem cell and oncology companies including Mesoblast, Cynata, and Merrimack.
     • keywords: acute; addition; administration; allogeneic; alofisel; analysis; anti; approach; associated; better; bioengineering; biologics; blood; bone; cancer; capacity; cardiac; cells; challenges; clinical; complement; control; cord; cqas; critical; cryopreservation; culture; cxcr4; cytokines; cytotoxic; days; delivery; dependent; development; different; disease; drug; ecm; effect; effective; efficacy; engineered; engineering; enhanced; example; expansion; expression; factors; fig; fistulas; function; gene; graft; growth; gvhd; heterogeneity; higher; homing; host; hours; human; hydrogels; hypoxia; ibmir; ido; immune; immunomodulatory; impact; improved; increase; indications; infarcted; inflammation; inflammatory; infusion; injection; innate; insufficient; intravenous; j.m.k; k.s; key; large; local; low; magnetic; major; manufacturing; marrow; mesenchymal; mesenchymal stem; mesenchymal stromal; model; molecules; mouse; msc product; msc therapies; mscs; multiple; myocardium; new; non; novel; number; oncolytic; outcome; passage; patients; perianal; phase; placebo; population; potency; potential; preclinical; priming; process; product; proliferation; promising; properties; quality; recent; regenerative; related; residence; response; results; retention; safety; secretion; simple; single; site; small; stage; stem; stem cells; strategies; strategy; stromal; stromal cells; studies; study; success; suppression; surface; survival; systemic; target; thawing; therapeutic; therapies; therapy; time; tissue; treatment; trial; tumor; use; viability; viral; virus; vitro; vivo
     • versions: original; plain text
133. cord-353887-f4yd7guj
     • author: Tang, Yujun
     • title: Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies
     • date: 2020-07-10
     • words: 8554
     • flesch: 36
     • summary: medRxiv Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis Tocilizumab, an anti-IL6 receptor antibody, to treat Covid-19-related respiratory failure: a case report First case of COVID-19 in a patient with multiple myeloma successfully treated with tocilizumab A case of novel coronavirus disease 19 in a chronic hemodialysis patient presenting with gastroenteritis and developing severe pulmonary disease Dramatic improvement after Tocilizumab of a severe COVID-19 in a child with sickle cell disease and acute chest syndrome Tocilizumab treatment in COVID-19: a single center experience Effective treatment of severe COVID-19 patients with tocilizumab Pilot prospective open, single-arm multicentre study on off-label use of tocilizumab in severe patients with COVID-19 Use of tocilizumab for COVID-19 infection-induced cytokine release syndrome: a cautionary case report EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update Safety of synthetic and biological DMARDs: a systematic literature review informing the 2019 update of the EULAR recommendations for the management of rheumatoid arthritis Negative regulation of nuclear factor-kappaB activation and function by glucocorticoids Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation Kelley's Textbook of Rheumatology E-Book The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province Corticosteroid treatment of patients with coronavirus disease 2019 ( Besides, corticosteroids, programmed cell death protein (PD)-1/PD-L1 checkpoint inhibition, cytokine-adsorption devices, intravenous immunoglobulin, and antimalarial agents could be potentially useful and reliable approaches to counteract cytokine storm in COVID-19 patients.
     • keywords: activation; acute; analysis; anti; antimalarial; artemisinin; artesunate; blood; cases; cause; ccl2; cd8; cells; characteristics; checkpoint; chemokines; china; chinese; clinical; colleagues; concentration; coronavirus; corticosteroids; cov-2; covid-19; covid-19 patients; current; cxcl10; cytokine storm; cytokines; dcs; death; disease; drugs; evidence; exhaustion; expression; factor; family; features; function; high; human; ifn; il-10; il-6; il-8; ill; immune; increase; induced; infection; inflammatory; inflammatory cytokines; inhibitor; innate; interferon; kinase; lead; levels; like; lung; lymphocytes; macrophages; malaria; manuscript; medicine; mers; meta; mice; model; monocytes; mortality; novel; pathway; patients; pd-1; pneumonia; potential; pro; production; protein; receptor; regulation; release; respiratory; response; results; safety; sars; sepsis; severe; shock; signaling; storm; studies; study; survival; syndrome; t cells; target; tcz; th17; therapy; tlr2; tnf; tocilizumab; transcription; treatment; use; viral; viruses
     • versions: original; plain text
134. cord-354216-4khdcjed
     • author: Sultan, Shahnaz
     • title: AGA Institute Rapid Review of the GI and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19
     • date: 2020-05-11
     • words: 5643
     • flesch: 38
     • summary: Therefore, in high prevalence settings, among patients presenting with new onset diarrhea, monitoring for the development of COVID-19 symptoms and considering referring patients for COVIDtesting is reasonable especially if testing capacity is not limited. In a handful of studies, diarrhea and nausea preceded the development of other COVID-19 related symptoms.
     • keywords: abdominal; abnormalities; acute; additional; admission; adverse; aga; analysis; bias; care; cases; certainty; characteristics; china; clinical; cohort; common; comorbidities; coronavirus; cov-2; covid-19; data; diarrhea; disease; drug; effects; elevations; evidence; gi symptoms; high; hospital; inclusion; infection; information; initial; injury; institute; lfts; liver; lopinavir; majority; management; manifestations; meta; nausea; number; outcomes; outpatients; pain; pandemic; patients; pneumonia; practice; presence; prevalence; process; reported; respiratory; review; risk; ritonavir; sars; severe; severity; stool; studies; study; symptoms; testing; time; treatment; unique; vomiting
     • versions: original; plain text