Bibliography

This is an automatically generated bibliography describing the content of this study carrel.

1. cord-001079-v01vwu00
   • author: Thoden, J.
   • title: Therapy and prophylaxis of opportunistic infections in HIV-infected patients: a guideline by the German and Austrian AIDS societies (DAIG/ÖAG) (AWMF 055/066)
   • date: 2013-09-14
   • words: 12704
   • flesch: 36
   • summary: The review presented here is a translation of a short version of the German–Austrian Guidelines of opportunistic infections in HIV patients. Results of the Swiss HIV Cohort Study prove that consequent isoniazid (INH)-prophylaxis in HIV patients with latent TB significantly reduces the risk of a relapse [22] .
   • keywords: active; acute; advanced; aids; alternative; amb; antiretroviral; antiretroviral therapy; art; atovaquone; available; avium; azithromycin; blind; candidiasis; carinii; cases; cd4; cells; cerebral; choice; cidofovir; clarithromycin; clear; clinical; cmv; cohort; combination; complex; count; cryptococcal; cryptosporidiosis; cytomegalovirus; daily; data; day; days; diagnosis; discontinuation; disease; dose; double; drug; effective; effects; efficacy; encephalitis; esophageal; ethambutol; fluconazole; foscarnet; gancyclovir; genital; germany; group; guidelines; herpes; higher; hiv; hiv-1; human; immune; immunodeficiency; incidence; infected; infection; inflammatory; initiation; iris; lesions; leukoencephalopathy; long; maintenance; manifestations; members; meningitis; months; mortality; multifocal; mycobacterium; negative; ntm; oral; oropharyngeal; patients; pcp; pentamidine; pml; pneumocystis; pneumonia; positive; possible; prevention; primary; progressive; prophylaxis; prospective; pyrimethamine; randomized; recommendations; reconstitution; regimen; resistance; response; results; retinitis; rifabutin; rifampicin; risk; secondary; severe; simplex; smx; societies; specific; studies; study; sulfadiazine; sulfamethoxazole; syndrome; table; term; therapy; tmp; toxoplasmic; toxoplasmosis; treatment; trial; trimethoprim; tuberculosis; use; virus; weeks; zoster
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2. cord-001690-cn21fgug
   • author: Franceschi, Valentina
   • title: BoHV-4-Based Vector Single Heterologous Antigen Delivery Protects STAT1((-/-)) Mice from Monkeypoxvirus Lethal Challenge
   • date: 2015-06-18
   • words: 6799
   • flesch: 46
   • summary: This work demonstrated the efficacy of BoHV-4 based vectors and the use of BoHV-4 as a vaccine-vector platform. In summary, our findings have demonstrated that BoHV-4 based vectors can be used as vaccines to protect against a lethal MPXV challenge in mice.
   • keywords: -tk; a29lgd; africa; agent; animal; antigens; b6rgd; bath; bek; bohv-4; booster; bovine; cages; cells; challenge; chloramphenicol; clinical; cmv; combination; combo; confluent; congo; control; culture; cut; days; disease; dmem; dna; ef1α; experimental; expression; fbs; fig; gene; genome; herpesvirus; human; igk; induced; infected; infection; lethal; loss; m1rgd; medium; mice; min; model; monkeypox; morbidity; mortality; mouse; mpxv; mva; nhei; non; orfs; pbac; pcmv; peptide; plasmid; post; potential; promoter; protection; protein; ptk; recombinant; replication; restriction; sequence; smallpox; stat1; strain; studies; study; vaccinated; vaccination; vaccines; vaccinia; vectors; viral; virus; vivo; vp2; water; weight; δtk
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3. cord-001938-n2d5fw2f
   • author: Ong, David S. Y.
   • title: Cytomegalovirus reactivation and mortality in patients with acute respiratory distress syndrome
   • date: 2016-03-01
   • words: 4487
   • flesch: 32
   • summary: CMV reactivation CMV reactivation occurred in 74 (27 %) of the included patients (Table 1 ). We aimed to estimate the attributable effect of CMV reactivation on mortality in immunocompetent ARDS patients.
   • keywords: acute; admission; analysis; ards; care; cause; clinical; cmv; cmv reactivation; confounding; cytomegalovirus; day; days; death; dependent; disease; distress; effect; estimates; hazard; high; icu; ill; immunocompetent; infection; intensive; loads; mechanical; modeling; mortality; onset; outcome; overall; patients; possible; primary; pulmonary; ratio; reactivation; regression; respiratory; results; risk; sensitivity; seropositive; severity; shr; specific; study; subdistribution; successful; syndrome; table; time; treatment; use; ventilation; viral; weaning
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4. cord-003085-7krf1yxz
   • author: Li, Xi
   • title: Cytomegalovirus infection and outcome in immunocompetent patients in the intensive care unit: a systematic review and meta-analysis
   • date: 2018-06-28
   • words: 3797
   • flesch: 37
   • summary: However, whether CMV infection or CMV reactivation contributes to mortality of immunocompetent patients remains unclear. For CMV seropositive patients, the OR for mortality in patients with CMV reactivation as compared with patients without CMV reactivation was 1.72 (95%CI 1.04–2.85, I(2) = 29%, n = 664).
   • keywords: 95%ci; additional; analysis; antiviral; blood; care; cause; clinical; cmv; cmv infection; critically; cytomegalovirus; data; days; detection; drugs; figure; file; higher; human; i(2; icu; ill; immune; immunocompetent; incidence; infection; intensive; manuscript; mechanical; median; meta; mortality; n =; organ; outcome; patients; pcr; rate; reactivation; results; sepsis; stay; studies; study; treatment; ventilation
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5. cord-003376-2qi4aibx
   • author: van de Groep, Kirsten
   • title: Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study
   • date: 2018-12-18
   • words: 3893
   • flesch: 38
   • summary: Patients with CMV reactivation had a more pronounced increase of IP-10 (median percentage difference of 44% versus −15%) and decrease of IL-1RA (median percentage difference of −41% versus 0%) on day 7 after viremia onset compared with CMV seropositive patients without reactivation. Based on previous studies in ICU patients, there is a clear pathophysiological link between inflammation and immune suppression on the one hand and the subsequent risk of CMV reactivation on the other
   • keywords: admission; analyses; biomarkers; care; clinical; cmv; cmv reactivation; cohort; comparison; course; cytomegalovirus; day; days; differences; effect; groups; host; icu; il-1ra; il-6; ill; immune; immunocompetent; induced; infection; ip-10; iqr; levels; matching; median; mixed; model; mortality; multiple; non; observed; onset; patients; percentage; plasma; primary; prior; reactivation; response; risk; samples; secondary; sepsis; seronegative; seropositive; studies; study; table; time; trends; viremia
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6. cord-004059-furt6xcn
   • author: Hraiech, Sami
   • title: Herpes simplex virus and Cytomegalovirus reactivation among severe ARDS patients under veno-venous ECMO
   • date: 2019-12-23
   • words: 3392
   • flesch: 38
   • summary: The role of Herpesviridae pre-emptive treatment among ICU patients has been recently evaluated in a randomized controlled trial (RCT) (NCT 02152358). The coefficient designates the number of days by which the different endpoints are affected Data are presented as median and interquartile range or absolute value and percentage a p < 0.05 compared with non-reactivation group Until today, no data have been published concerning Herpesviridae reactivation in ICU patients under VV ECMO for severe ARDS.
   • keywords: acute; acyclovir; analysis; ards; care; clinical; cmv; cytomegalovirus; data; days; duration; ecmo; failure; herpesviridae; high; hospital; hsv; icu; ill; immunocompetent; infection; intensive; length; longer; mechanical; mortality; non; organ; outcomes; patients; prolonged; pulmonary; reactivation; respiratory; severe; simplex; stay; study; treatment; veno; venous; ventilation; viral; vs.
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7. cord-004591-2hchnlwb
   • author: Wicker, S.
   • title: Seroprävalenz von Antikörpern gegen schwangerschaftsrelevante virale Infektionserreger bei Mitarbeiterinnen im Gesundheitswesen
   • date: 2012-07-25
   • words: 2014
   • flesch: 45
   • summary: Nach Einführung der Rötelnimpfung sank der Anteil der Frau en im gebärfähigen Alter ohne Röteln antikörper sukzessive ab und liegt zurzeit bei unter 3% Die Seroprävalenz von VZVIgG bei Frau en im gebärfähigen Alter bewegt sich in Deutschland bei etwa 96-97%
   • keywords: als; alter; auch; auf; aus; b19; bei; care; children; cmv; congenital; cytomegalovirus; das; daten; dem; der; des; deutschland; die; diseases; eine; frauen; für; gebärfähigen; gegen; hcws; healthcare; hospital; human; infection; infektionen; ist; jahren; jedoch; kann; können; liegt; mit; muschg; mutter; nach; nicht; non; nur; nurses; occupational; oder; parvovirus; personal; physicians; population; pregnancy; pregnant; primary; risk; röteln; schwangeren; schwangerschaft; schwangerschaftsrelevante; seroprevalence; seroprävalenz; sich; sind; ssw; study; und; unter; virale; von; vor; vzv; werden; werdende; women; workers; zum; zur
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8. cord-004643-uu4uipfy
   • author: Hasan, Mohammad Rubayet
   • title: Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report
   • date: 2020-03-20
   • words: 3022
   • flesch: 32
   • summary: The case highlights both the risk of acquiring MDR superbugs and the severity of these infections in HLH patients. While these factors likely put HLH patients at high risk of infection with MDROs, no such reports has been published to date and the clinical course of such infections in these patients remains unknown.
   • keywords: antibiotic; antimicrobial; antiviral; bacteria; bleeding; blood; case; clinical; cmv; coli; course; culture; cytomegalovirus; data; day; drug; fever; ganciclovir; genes; genetic; genome; hemophagocytic; high; history; hlh; hospital; india; infection; isolate; lymphohistiocytosis; manuscript; mdros; mechanisms; metagenomic; multidrug; multiple; pandrug; patient; picu; pid; pneumoniae; positive; resistance; respiratory; risk; sequence; sequencing; therapy; treatment; urine; vancomycin; vre; wgs
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9. cord-004675-n8mlxe7p
   • author: None
   • title: 2019 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference
   • date: 2019-02-26
   • words: 86609
   • flesch: 43
   • summary: Background: Patients with primary immune deficiencies characterized by severe T lymphopenia and/or poor T cell function and patients posthematopoietic cell transplantation are at high risk of severe viral infections. In this study, we investigated effect of IL12R1 mutation in IL-12/IFNaxis by evaluation of patients whole blood cell response to IL-12 and IFN-, IL-12R1 expression in PBMCs and T cell blasts.
   • keywords: + cells; abdominal; abnormal; abnormalities; abscesses; absence; absent; absolute; acid; activation; activity; acute; ada; addition; administration; admission; adult; adult patients; advanced; adverse; affected; affected patients; afp; african; age; age patients; aged; agents; allele; allergy; allogeneic; alpha; alps; altered; alternative; american; amino; anakinra; analysis; anemia; anti; antibiotics; antibodies; antibody; antibody deficiency; antigen; antimicrobial; apeced; apoptosis; appropriate; arthritis; aspergillus; assay; assessment; associated; association; asthma; asymptomatic; ataxia; atopic; atypical; autoantibodies; autoimmune; autoimmunity; autoinflammatory; autologous; autosomal; available; average; b cells; background; bacterial; bartonella; baseline; bcl11b; beta; bilateral; binding; biopsy; birth; blood; blood cell; bone; bowel; boy; brain; broad; bronchiectasis; brother; c1q; cancer; candida; candidiasis; capacity; card11; care; carrier; case; caucasian; causes; cd19; cd27; cd3; cd34; cd4; cd40l; cd8; cd8 t; cell counts; cell development; cell function; cell lymphopenia; cell numbers; cell proliferation; cell receptor; cell transplantation; cellular; center; central; cervical; cgd; ch50; change; characteristics; chart; chest; chh; childhood; children; chimerism; chronic; class; clear; clinical; clinical diagnosis; clinicians; cmv; cohort; colitis; combined; combined immunodeficiency; common; comorbidities; comparable; complement; complete; complex; complicated; complications; compound; concentrations; concern; conclusions; conditioning; conditions; congenital; consanguineous; consistent; continued; contrast; control; conventional; copa; cord; correlation; corticosteroids; counseling; counts; course; criteria; critical; csf; ctla-4; ctla4; cultures; cvid patients; cytokine; cytometry; cytopenias; cytotoxicity; daily; damage; data; days; death; decision; decrease; defective; defects; deficiencies; deficient patients; definitive; delay; delayed; deletion; delta; demographic; department; dependent; development; dhr; diagnosis; diarrhea; differences; different; differential; differentiation; diffuse; discussion; disease; disorders; distinct; dna; dock8; domain; dominant; donor; dose; double; drug; dsdna; duffy; duration; dysfunction; dysregulation; earlier; early; ebv; ecs; eczema; effective; effects; efficacy; elevated; encodes; endocarditis; endoscopy; engraftment; enteropathy; enzyme; episodes; errors; essential; established; etanercept; etiology; evaluation; events; evidence; examination; exome; exon; expansion; expression; extl3; face; facial; factor; fadd; failure; familial; family; fas; fatigue; features; febrile; female; fever; figure; fill; findings; flow; fluid; fmf; following; foxn1; free; frequency; frequent; function; fungal; future; gain; gastrointestinal; gata2; gene; general; generation; genetic; genomic; gof; good; granulomatous; greater; group; growth; gvhd; h2ax; hair; haploinsufficiency; hct; healthy; help; hematopoietic; hepatic; hepatitis; heterozygous; hies; hies patients; high; higher; history; hla; hlh; homozygous; hospital; hospitalization; host; hours; hscs; hsct; hsct patients; hsp; human; humoral; hydroxychloroquine; hypertension; hypogammaglobulinemia; hypomorphic; ibd; identification; ifn; iga; igd; ige; igg; igg4; ighy; igm; igrt; igsc; ikaros; il-18; il-2; il-6; illness; imaging; immune; immune cell; immune deficiency; immunodeficiency; immunodeficiency patients; immunoglobulin; immunological; immunology; immunosuppression; impact; impaired; important; improved; improvement; inborn; incidence; increased; index; individuals; induced; infants; infections; inflammation; inflammatory; infliximab; information; infusion; inhibitor; initial; innate; institute; intensity; interferon; interpretation; interstitial; intracellular; intravenous; introduction; invasive; irradiation; isolated; ivig; key; kidney; knowledge; known; laboratory; lack; large; later; lead; left; lesions; leukemia; levels; life; ligand; likely; limited; literature; liver; local; long; loss; low; low t; lower; lung; lung disease; lupus; lymphadenopathy; lymphocyte; lymphoid; lymphoma; lymphopenia; lymphoproliferation; majority; male; malignancies; malignancy; management; manifestations; markers; marrow; mass; maturation; mcl; mean; mechanism; median; medical; medications; medicine; mefv; members; memory; memory b; mental; metabolic; methods; mice; mild; minimal; missense; mitogen; mm3; mmr; model; moderate; molecular; monogenic; months; mortality; mother; mouse; mri; multiple; mutant; mutations; mycobacterial; n=1; nasal; national; natural; naã¯ve; naã¯ve t; nbs; necrosis; need; negative; neurological; neutralizing; neutropenia; neutrophil; newborn; nfkb2; niaid; nih; nk cells; nodes; non; normal; normal t; northwell; novel; novo; number; oas1; objectives; old; older; ongoing; onset; oral; organs; osteomyelitis; otitis; outcomes; overall; oxidase; pad; pain; pancytopenia; panel; parameters; parents; partial; participants; particular; past; pathogenic; pathway; patient b; patients; patients clinical; pbmcs; pcr; pediatric; pediatric patients; percentile; pericarditis; period; peripheral; persistent; phase; phenotype; phenotyping; phosphorylation; physical; pid; pid patients; pidd; pids; pjp; plasma; platelet; plcg2; plt; pneumococcal; pneumonia; pneumonitis; poig; poor; population; positive; possible; post; potential; prednisone; pregnancy; presence; present; presentation; presumed; prevalence; previous; primary; primary immune; primary immunodeficiency; prior; process; production; profile; progressive; proliferation; prolonged; prophylaxis; proportion; protective; protein; protocol; providers; pulmonary; purpura; qol; quality; quantification; quantitative; radiosensitivity; rag1; range; rare; rash; rate; rationale; rdd; reactive; receiving; recent; receptor; recessive; recipient; recombination; reconstitution; recurrent; recurrent infections; reduced; reference; refractory; regimen; region; registry; regulatory; related; relative; renal; repair; repeat; repertoire; replacement; reported; reports; required; research; resolution; respiratory; response; results; retrospective; review; right; risk; rituximab; rna; role; rotavirus; routine; rvt-802; s1p; safety; samples; scid; score; screening; secondary; seizures; self; sepsis; sequence; sequencing; series; serum; setting; severe; severe t; severity; siblings; sided; signaling; signature; significant; signs; similar; single; sinopulmonary; sinusitis; sister; site; size; skin; small; specific; spectrum; splenomegaly; spontaneous; standard; state; status; stem; stem cell; steroids; stim1; stimulated; stimulation; streptococcus; studies; study; subcutaneous; subjects; submission; subsequent; subsets; successful; suggestive; summary; support; surgical; survey; survival; susceptibility; suspicion; switched; symptoms; syndrome; system; systemic; t cells; table; targeted; tcl; tcr; telangiectasia; telomere; term; terminal; testing; tests; tetanus; tfh; therapeutic; therapies; therapy; thought; threshold; thrombocytopenia; thymic; thymus; time; tissue; titers; tnf; tool; total; tract; transient; transplant; transplantation; treatment; trec; treg; trial; trough; ulcers; uncertain; underlying; understanding; underwent; undetectable; unique; university; unknown; unrelated; upper; usa; use; usidnet; vaccination; vaccine; values; variable; variant; vasculitis; viral; viremia; virus; vitro; vivo; vsts; warts; weekly; weeks; weight; wes; white; work; workup; worsening; xla; years; years old; yrs; zap70
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10. cord-004986-en7taikk
    • author: Nagy, Nathalie
    • title: Infections gastro-intestinales chez le patient immunocompromis
    • date: 2002
    • words: 6150
    • flesch: 50
    • summary: Certaines 6tudes rapportent des strongyloidoses diss6min6es chez des patients immunocompromis. Bien avant les 6pid6mies de sida, le toxoplasme 6tait reconnu comme protozoaire responsable d'infections opportunistes chez les patients immunocompromis.
    • keywords: 6galement; 6t6; 6tre; acid; agents; aids; albicans; aux; biopsies; biopsy; bowel; candida; candidiasis; candidose; cas; cases; cd4; cells; cellules; ces; cette; chez; chez les; cmv; colonisation; coloration; comme; common; cryptosporidium; d'une; d6crite; dans; des; diagnostic; diarrh6es; digestif; digestive; disease; diss6min6e; essentiellement; est; fast; fig; filaments; fois; forme; fr6quemment; fr6quente; frequent; g6n6rale; gastrique; gastro; gastrointestinal; giardia; grade; herpetique; histologique; hiv; homosexuels; identification; immunocompromis; infecte; infections; inflammation; intestinale; invasive; involvement; l'affection; lamina; les; les patients; lorsque; lymphocytes; mais; maladie; microsporidium; moins; mucosal; muqueuse; niveau; nombre; non; number; oesophageal; oesophagus; opportunistes; organismes; par; partir; pas; pathog; pathog6ne; patients; patients sida; peut; peuvent; population; pour; pr6sence; pr6sentant; prevalence; propria; pulmonaire; que; qui; r6sultant; rement; rencontre; responsable; sein; semble; sida; site; small; soit; sont; souvent; specific; spores; stain; survient; syndrome; taux; tissue; tract; tractus; tuberculosis; une; virus; ziehl; ~tre
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11. cord-005225-7uuilki4
    • author: Paduch, Darius A.
    • title: Viral lower urinary tract infections
    • date: 2008-03-26
    • words: 5703
    • flesch: 33
    • summary: The highdose chemotherapy conditioning was the best predictor of developing viral hemorrhagic cystitis Viral infections of the lower urinary tract are usually seen in immunocompromised patients, especially in solid organ and stem cell transplantation recipients, and are the most common cause of hemorrhagic cystitis in this group of patients
    • keywords: active; adenovirus; adv; allogeneic; antibodies; antigen; assay; associated; bkv; bladder; bone; cause; cell; changes; children; cidofovir; clinical; cmv; common; culture; cystitis; cytology; days; detection; diagnosis; dna; elisa; hemorrhagic; hemorrhagic cystitis; herpes; high; host; hsv; human; immune; immunocompetent; immunocompromised; important; infection; load; lower; marrow; method; molecular; mortality; organ; pathogens; patients; pcr; polyomavirus; presence; recipients; renal; results; risk; significant; simplex; solid; specimen; stem; techniques; time; tract; transplantation; treatment; type; urinary; urine; utis; viral; virus; viruses
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12. cord-005453-4057qib7
    • author: None
    • title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session
    • date: 2019-07-03
    • words: 276280
    • flesch: 51
    • summary: Goals: In the present study, we describe the frequencies of CRE colonization and analyzed its relationship with development of CRE bacteremia and mortality in two different scenarios: stem cell transplant patients (HSCT) and Leukemia patients. The aim of this study was to analyse a single centre experience with HSCT patients requiring ICU admission and the factors affecting outcome.
    • keywords: +100; +14; +180; +30; +365; +60; +90; /day; /kg; 1,2; 1st; 1x10; 2nd; 95%ci; ab0; abdominal; abnormalities; abo; absence; absolute; abstract; acceptable; access; acid; active; active disease; activity; acute graft; acute gvhd; acute leukemia; acute myeloid; addition; adenovirus; adequate; administration; admission; adolescents; adult patients; adults; advanced; advantage; adverse; advt; aes; affected; affected patients; age group; age range; aged; agents; aggressive; agvhd; aic; aim; albumin; alemtuzumab; alive patients; allele; allo hsct; allogeneic bone; allogeneic cell; allogeneic donors; allogeneic hematopoietic; allogeneic hsct; allogeneic patients; allogeneic stem; allogeneic transplantation; allogenic; allograft patients; alloreactive; alloreactivity; allosct; allosct patients; alternative; aml patients; amounts; amphotericin; analysis; analyze; anemia patients; anti; antibiotic; antibodies; antibody; antifungal; antigen; antileukemic; antithymocyte; antiviral; apheresis; aplasia; aplastic; apoptosis; application; approach; appropriate; approved; april; area; arf; ascs; asct; aspergillosis; aspergillus; assay; assessment; associated; association; atg; auc; august; authors; autograft; autoimmune; autologous; autologous hematopoietic; autologous hsct; autologous patients; autologous stem; autologous transplantation; autophagy; availability; available; average; aza; b cells; bacteremia; bacterial; bal; barr; basal; based; baseline; basis; beam; beginning; beneficial; benefit; best; beta; better; bilirubin; biomarkers; biopsies; biopsy; bkv; blasts; bleeding; blinatumomab; blood; blood cells; blood group; blood patients; blood stem; blood transplantation; bmf; bmi; bmt; body; bone; bone marrow; boost; bortezomib; bos; boys; brain; brentuximab; brincidofovir; brother; bsi; budesonide; bumel; burden; busulfan; calcineurin; calcium; calculated; cancer; cancer cell; candida; candidates; candidemia; candidiasis; capacity; car; cardiac; care; caregivers; cart; carv; cases; category; cause; ccr4; cd10; cd19; cd25; cd34; cd34 cells; cd4; cd45ra; cd52; cd56; cd66b; cd8; cdi; cell collection; cell count; cell death; cell depletion; cell disease; cell dose; cell free; cell function; cell graft; cell infusion; cell levels; cell lines; cell lymphoma; cell mobilization; cell non; cell numbers; cell population; cell products; cell proliferation; cell reconstitution; cell recovery; cell replete; cell source; cell subsets; cell therapy; cell transplantation; cell transplants; cell viability; cells; cellular; cellularity; center; central; centre; cerebral; cfdna; cfu; cgd patients; chain; changes; characterization; characterized; chemosensitive patients; chemotherapy; chest; childhood; children; chimeric; chimeric patients; chimerism; china; choice; chronic graft; chronic gvhd; cidofovir; cik cell; cir; class; classical; classification; clearance; clinical; clinical background; clinical study; clinimacs; cll; clonal; clones; close; cml; cmv; cmv disease; cmv infection; cmv prophylaxis; cmv reactivation; cns; cohort; collected; collection; colonization; colonized patients; colony; combination; combined; common; comorbidities; comparable; compare; comparison; complete; complete donor; complete response; complexity patients; complications; components; composition; concentration; conclusions; conditioning; conditioning regimen; conditions; confidence; confirmed; conflict; congenital; consecutive patients; consensus; consent; consideration; consistent; consolidation; context; continued; continuous; contrast; contribute; control; control group; conventional; conversion; copies; copy; cord; cord blood; correlate; correlation; corresponding; corticosteroid; cost; counseling; count; countries; country; course; cox; cpx-351; cr1; cr2; creatinine; criteria; critical; cross; crp; crs; crucial; cryopreservation; cryopreserved patients; csa; csf; ctls; culture; cumulative; cumulative incidence; curative; curative treatment; cure; current; cutaneous; cvc; cycles; cyclophosphamide; cyclosporine; cystitis; cytarabine; cytogenetic; cytokine; cytomegalovirus; cytometry; cytopenias; cytoreductive; cytotoxicity; daily; damage; dasatinib; data; data patients; database; date; day mortality; days; days post; dcs; death; decades; december; decision; declare; decreased; defibrotide; deficiency; degree; delayed; demographic; demyelinating; dendritic; department; depleted; desensitization; detailed patients; detectable; detection; determination; determined; developed; development; device; dexamethasone; dfs; diagnosis; diarrhea; differences; different; differentiation; difficult; diffuse; direct; discharge; disclosure; disclosure background; disclosure results; discontinuation; disease; disease control; disease free; disease patients; disease progression; disease prophylaxis; disease relapse; disease response; disease status; dismal; disorders; distinct; distribution; dlbcl patients; dli; dmso; dna; donations; donor; donor age; donor cells; donor chimerism; donor cmv; donor graft; donor group; donor lymphocyte; donor source; donor t; donor transplant; donor type; doppler; dosage; dose; dosing; double; dpb1; drug; dsa; ductopenia; duration; dysfunction; e.g.; earlier; early; easix; ebmt; ebv; ecp; ecs; eculizumab; education; effect; effective; effectiveness; effector; efficacy; efs; elafin; elderly; elevated; eligible patients; elisa; elispot; eltrombopag; employee; encephalitis; encephalopathy; encouraging; endothelial; endothelial cells; endpoint; engraftment; enhanced; enriched; enrichment; entire; enzyme; epag; episodes; epstein; equivalent; essential; established; estimate; etanercept; etoposide; european; evaluable patients; evaluation; events; evidence; evs; exact; examination; excellent; exercise; expansion; expected; experience; exposure; expression; extended; extensive; extracorporeal; extramedullary; facs; factors; failure; failure patients; family; fanconi; faster; fatal; favorable; fb2; feasibility; feasible; features; febrile; february; female; ferritin; fertility; fever; figure; final; financial; findings; flow; flt3; flubu; fluconazole; fludarabine; flumel; fluorescence; fmt; fnh; focus; fold; following; followup; forms; foundation; fractions; fractures; free; free survival; freezing; frequency; frequent; fresh; frozen; function; funding; fungal; future; gamma; ganciclovir; gastrointestinal; gcsf; gender; general; generation; genes; genetic; genotype; germany; gi gvhd; global; globulin; good; grade; grade ii; graft; graft failure; graftversus; granulocyte; gray; greater; grfs; group; group b; group patients; growth; guidelines; gut; gvhd grade; gvhd group; gvhd incidence; gvhd patients; gvhd prophylaxis; gvhd rate; gvhd therapy; gvl; hadv; haematopoietic; half; hand; haploidentical; haploidentical donor; haploidentical hsct; haploidentical patients; haploidentical stem; haploidentical transplantation; haplosct; harvest; hazard; hbv; hct; hdct; hdm; hdt; healthy; help; hematological; hematological patients; hematology; hematopoietic cell; hematopoietic stem; hemoglobin; hemolysis; hemorrhage; hepatic; hepatitis; hev; hid; high; high dose; high grade; high mortality; high risk; higher; higher median; highest; histological; historical; history; hiv; hla; hla donor; hlh patients; hma; hodgkin; home; honoraria; hospital; hospitalization; host disease; hours; hscs; hsct =; hsct background; hsct complications; hsct group; hsct methods; hsct outcome; hsct patients; hsct program; hsct recipients; hsct relapse; hsct response; hsct setting; hsct treatment; hsos; human; hypertension; hypothesis; i.v; ibrutinib; icu; identification; ifd; ifn; igg; ii patients; iii; iks; il-15; il-2; image; imaging; immediate; immune; immune cell; immunity; immunodeficiency; immunoglobulin; immunological; immunomodulatory; immunosuppressive; immunotherapy; impact; impaired; impairment; important; improved; improvement; improving; incidence; inclusion; incompatibility; increase; independent; index; india; indications; individual; individual patients; induced; induction; infants; infection; infection patients; inferior; inflammation; inflammatory; influence; information; informed; infusion; inhibition; inhibitors; initial; initiation; injury; inkt; institute; institution; intensity; intensity conditioning; intensive; interactions; interest; intermediate; international; interval; intervention; intestinal; intestinal gvhd; intracellular; intravenous; introduction; invasive; involvement; ips; iqr; iron; irradiation; isa; isolated; isolation; itd; itma; iv acute; january; japan; jazz; july; june; kaplan; karnofsky; karyotype; key; kidney; killer; killing; kinetics; kit; kits; knowledge; known; krp203; laboratory; lack; large; later; ldh; lead; leading; left; length; lesions; letermovir; leukaemia; leukapheresis; leukemia cells; leukemia patients; leukemic; leukocyte; levels; lfs; life; like; likely; limitations; limited; limiting; line; line treatment; lineage; linear; liposomal; literature; little; liver; load; local; logistic; long; longer; loss; lower; ltv; lung; lymphoblastic; lymphocyte; lymphoid; lymphoma patients; lymphomas; lymphoproliferative; main; maintenance; major; majority; making; male patients; males; malignancies; malignant; malignant disease; maltophilia; management; manifestations; mann; manufacturing; march; maria; markers; marrow; marrow transplantation; mass; matched; matching; maternal; mature; maximum; mcl; mds patients; mean; measles; measurements; mechanism; median; median age; median cd34; median cell; median day; median donor; median dose; median duration; median follow; median frequency; median group; median interval; median neutrophil; median number; median os; median overall; median pre; median survival; median time; median treatment; medical; medicine; medium; meier; melphalan; memory; mesenchymal; metabolic; methods; methotrexate; mets; mfd; mfi; mice; microbiological; microbiota; mild; miltenyi; minimal; minimum; minor; minutes; mirna; mismatched; mixed; mlc; mmf; mmud; mnc; mobilization; mobilizers; model; moderate; modified; mofetil; molecular; moment; monitoring; monoclonal; monocytes; mononuclear cells; months; months post; morbidity; mortality; mothers; motion; mpn; mrd; mrd group; mri; mscs; msd; msd hsct; mtx; mucositis; mud; multicenter; multiple; multivariate; multivariate analysis; mutations; mycophenolate; myeloablative; myeloablative conditioning; myelodysplastic; myelofibrosis; myeloid; myeloma patients; n=1; n=10; n=11; n=12; n=13; n=14 patients; n=15; n=2; n=21; n=22; n=23; n=3; n=4; n=5; n=6; n=7; n=8; n=9; national; natural; nausea; naïve; nd hsct; necessary; needed; needs; negative patients; negativity; neoplasms; neuroblastoma; neurological; neutropenia; neutrophil; new; nhl; nih; nivolumab; nk cells; nkg2d; nlr; nma; non; nonmalignant; normal; note; novel; november; novo; npm1; nrm; nucleated; number; objective; observation; observed; obstruction; obtaining; obvious; occlusive; occlusive disease; occurrence; october; offer; offspring; older patients; oncology; ones; ongoing; onset; optimal; option; oral; order; organ; origin; original; outcome; ovarian; overall; overall response; overall survival; oxygen; ozogamicin; p=0.002; p=0.01; paediatric patients; pain; pairs; panel; panobinostat; parameters; parents; partial; participants; particular; pathogenesis; pathological; pathway; patient age; patients; patients background; patients characteristics; patients chronic; patients donors; patients higher; patients median; patients recipients; pattern; pbmcs; pbsc; pcnsl patients; pcr; peak; pediatric hsct; pediatric patients; peptide; percentage; performance; period; peripheral; peripheral blood; peripheral stem; persistent; pet; pfs; pgf patients; pharmaceuticals; phase; phenotype; photopheresis; physical; planned; plasma; platelet; platform; play; plerixafor; plt; plus; pneumocystis; pneumonia; pnh; points; pooled; poor; poorer; population; posaconazole; positive cell; positive patients; positivity; possibility; possible; post; post allo; post hsct; post transplant; potential; ppx; practice; pre; predictive; predictors; prednisone; preemptive; preferred; preliminary; preparation; presence; present; presentation; pressure; pretransplant; pretreated patients; prevalence; prevention; previous; primary; primary disease; primary graft; prior; probability; probable; problems; procedure; process; processes; processing; product; profile; prognosis; program; progression; project; proliferation; prolonged; promising; properties; prophylactic; proportion; prospective; protection; protein; protocol; proven; pt#2; ptcy; ptld; pts; pubertal; pubertal patients; pulmonary; purpose; qol; qpcr; quality; quantitative; rabbit; radiological; radiotherapy; randomized; range; rank; rapid; rare; rate; ratg; ratio; rbc; reaction; reactivation; reasons; received; recent; receptor; reconstitution; records; recovered; recovery; recurrent; red cell; reduced; reduction; reference; refractory; refractory acute; refractory disease; refractory gvhd; refractory patients; regard; regimen; registry; regulation; regulatory; rejection; relapse; relapse incidence; relapse mortality; relapse rate; relapsing; related; relationship; relative; release; relevant; remaining; remission; renal; replacement; reported; reports; rescue; research; residual; residual disease; resistant; resistant patients; resolution; resolved; respect; respiratory; responders patients; response; results; retrospective; retrospective study; review; rfs; rhce; risk acute; risk aml; risk disease; risk factors; risk group; risk patients; risks; rituximab; role; romiplostim; routine; rsv; ruxolitinib; rzf; saa; safety; salvage; samples; sampling; sarcoma; sc patients; scale; scan; scd; schedule; scid; score; screening; second; second transplant; secondary; selected; selection; self; sensitivity; sepsis; september; septic; sequence; sequencing; sequential; series; serology; seropositive; serostatus; serotherapy; serum; sessions; setting; severe; severe acute; severe gvhd; severe patients; severity; sex; sga; shock; short; shorter; shows; sibling; sibling donor; sickle cell; signaling; significant; significant risk; signs; similar; single; sinusoidal; sirolimus; sister; site; size; skin; slightly; small; smx; social; society; software; sos; sources; species; specific; specificity; spectrum; spgf; spleen; splenomegaly; spontaneous; spp; spss; stable disease; stage; staining; standard; start; starting; statistical; status; stay; stem cell; step; steroid; steroid treatment; stimulated; stimulation; storage; strategies; strategy; stromal; strong; studies; study; study background; study group; study patients; study period; subgroup; subjects; suboptimal; subpopulations; subsequent; substantial; subtypes; successful; suffering; sufficient; suitable; superior; support; supportive; suppression; surface; surgical; surveillance; survival; survival rate; survive; survivors; susceptibility; sustained; symptomatic; symptoms; syndrome; system; systemic; t cells; table; tacrolimus; tandem; tapered; tapering; target; targeted; tbi; tcd; tcr; tcrαβ; team; technique; technology; term; term survival; test; testing; thalassemia; thalassemic patients; therapeutic; therapies; therapy; thiotepa; threshold; thrombocytopenia; thrombotic; thymic; thymoglobuline; tim3; times; timing; tissue; titers; tki; tma; tmp; tnc; tnf; tocilizumab; tolerability; tolerance; tolerated; tool; total; total patients; toxicities; toxicity; toxoplasma; tpo; traditional; trail; training; transduced; transduction; transfer; transformation; transformed; transfusion; transient; transplant characteristics; transplant complications; transplant conditioning; transplant cyclophosphamide; transplant disease; transplant high; transplant outcomes; transplant patients; transplant period; transplant recipients; transplant relapse; transplant therapy; transplantation background; transplantation results; transplantation unit; transplantations; transplanted; treatment; treatment option; treatment patients; trec; treg; trend; treosulfan; trial; trm; tumor; tumor cells; type; ucb; ucbt; ultrasound; umbilical; unclear; undergone; underlying; underwent; underwent hsct; unit; univariate; university; unknown; unmanipulated; unrelated; unrelated donor; unrelated hsct; untreated; upfront; upper; uric; urine; usa; use; useful; vaccination; vaccine; valganciclovir; validation; values; variables; variants; varied; variety; vascular; vector; vedotin; vein; veno; versus; vgpr; viability; viable; vip; viral; viremia; virus; viruses; visual; vitamin; vitro; vivo; vod; vod patients; volume; vomiting; voriconazole; vwf; wbc; weekly; weeks; weight; white; whitney; wide; withdrawal; women; work; working; world; worse; wt1; x10; y.o; year os; years; years old; years overall; years post; yield; younger patients; yrs
    • versions: original; plain text
13. cord-005460-ezrn8cva
    • author: None
    • title: Physicians – Poster Session
    • date: 2017-07-28
    • words: 287532
    • flesch: 53
    • summary: After three months of treatment patient showed an increase in T cells count (CD3, 411/mmc), and a decrease of toxic metabolites: AXP, 1.652 micromol/ml RBC; dAXP, 0.011 micromol/ml RBC; %dAXP, 0.7 maternal T-cell engraftment persists, despite a good response to the PEG-ADA therapy. Moreover, caspases pathway was significantly activated in thawing CD3+, CD56+ and CD14 + cells: FLICA+ cells % in thawing cells were, respectively, 16.8%, 31.1% and 6.2% vs 3%, 9.7% and o1% in fresh cells.
    • keywords: +100; +15; +28; +30; +60; 0.001; 1,2; 1st; 2nd; 6/10 patients; = ns; abdominal; abl1; abnormalities; absence; absolute; acceptable; access; account; acid; active; active disease; activity; acute graft; acute gvhd; acute leukemia; acute lymphoblastic; acute myeloid; acute patients; acyclovir; ada; addition; additional patients; adenovirus; adequate; adherence; adjusted; administration; admission; adoptive; adult patients; adults; advanced; advanced disease; advantage; adverse; affected patients; aged; agents; aggressive; agvhd grade; ahct; ahr; aic; aim; aims; akt; albumin; alc; alemtuzumab; algorithm; alive; allo hsct; allogeneic group; allogeneic hematopoietic; allogeneic hsct; allogeneic stem; allogeneic transplantation; allogenic; allograft; alloreactivity; allosct; alpha; alternative; amgen; aml patients; amphotericin; analysis; anemia; anti; antibacterial; antibiotics; antibodies; antibody; antifungal; antigen; antigenemia; antileukemic; antithymocyte; antiviral; apheresis; aplasia; aplastic; apoptosis; application; approach; appropriate; april; area; asct; asd; assay; assessment; associated; association; atg; atg group; auc; august; author; auto hsct; autoimmune; autologous; autologous hematopoietic; autologous hsct; autologous patients; autologous stem; autologous transplantation; automated; autosct; availability; available; average; b cell; bacteremia; bacterial; balanced; baltimore; based; baseline; basis; bcg; bcr; bcv; beac; beam; beam group; beam patients; bedside; bendamustine; beneficial; benefit; best; beta; better; bilirubin; biological; biomarkers; biopsies; biopsy; bkv; bladder; blasts; bleeding; blinatumomab; blood; blood cell; blood group; blood stem; blood transplant; body; bone; bone marrow; bortezomib; brain; bridge; brincidofovir; broad; bsbmt; bsi; bucy; burden; busulfan; busulphan; calcineurin; campath; cancer; cancer patients; candidates; capacity; cardiac; care; carmustine; cases; categories; catheter; cause; cbt; cbu; ccr7; ccs; cd16; cd19; cd34; cd34 cell; cd4; cd45ra; cd56; cd62l; cd8; cdi; cdv; cebpa; cell activation; cell acute; cell chimerism; cell collection; cell count; cell depletion; cell disease; cell dose; cell engraftment; cell function; cell graft; cell infusion; cell lines; cell lymphoma; cell mobilization; cell number; cell proliferation; cell recovery; cell replete; cell responses; cell source; cell survival; cell therapy; cell transplantation; cell treatment; cell viability; cells; cellular; center; central; centre; cerebral; cervical; cfu; chain; changes; characterized; chemotherapy; childhood; children; chimerism; choice; chop; chromosome; chronic graft; chronic gvhd; chspcs; ci =; cidofovir; cik; ciprofloxacin; circulating; classical; classification; classified; clearance; clinical; clinicians; clinimacs; cll; cml; cmv; cmv disease; cns; cohort; collected; collection; colony; color; combination; combined; common; comorbidities; comparable; compare; comparison; complement; complete; complete remission; complex; complicated; complications; composition; concentration; conclusion; concomitant; conditioning; conditioning regimen; conditioning therapy; conditions; confidence; confirm; conflict; consecutive days; consecutive patients; consensus; consent; consistent; consolidation; contents; context; continued; continuous; contrast; control; control group; control patients; controversial; conventional; copies; cord; cord blood; correlated; correlation; corresponding; corticosteroids; cost; count; countries; country; course; cox; cpap; cpt; cr group; cr patients; cr1; cr2; creatinine; criteria; critical; cross; crp; crs; crucial; crv; cryopreservation; cryopreserved; csa; csf; csf group; ctla4ig; ctp; culture; cumulative; cumulative incidence; curative; curative treatment; cure; current; cutaneous; cvc; cxcr3; cybor; cycle; cyclophosphamide; cyclosporine; cystitis; cytarabine; cytogenetic; cytokine; cytomegalovirus; cytometry; cytotoxic; cytotoxicity; d100; daily; damage; data; database; date; days; days patients; days post; dcs; death; decades; december; decision; decline; decontamination; decreased; deferasirox; defibrotide; deficiency; deficient patients; degree; delayed; delta; demographic; dendritic; density; dental; department; depleted; depletion; detailed; detection; determined; developed; development; device; dexamethasone; dfs; diagnose; diagnosis; diarrhea; differences; different; difficult; difficulties; diffuse; digestive; discharge; disclosure; discontinuation; disease; disease control; disease free; disease progression; disease prophylaxis; disease relapse; disease response; disease risk; disease status; disorders; disparity; distribution; divided; dlbcl patients; dli; dmso; dna; dnr; dock8 patients; donation; donor; donor cell; donor chimerism; donor engraftment; donor hematopoietic; donor hsct; donor lymphocyte; donor n; donor stem; donor transplantation; donor type; dose; dose chemotherapy; dose therapy; dosing; double; drug; dsa; durable; duration; dynamics; dysfunction; earlier; early; early hsct; ebmt; ebv; ecp; eculizumab; effect; effective; effective treatment; effectiveness; effector; efficacy; efficient; efs; elderly patients; elevated; eligible patients; elisa; eln; encouraging; endoscopy; endothelial; endpoint; engraftment; enriched; enrichment; enterovirus; entire; epidermal; episodes; equal; erythroid; essential; established; estimated; estimation; etoposide; european; evaluable patients; evaluated; evaluation; event; evidence; exact; examination; excellent; excess; existing; expansion; experience; experimental; exposure; expression; extended; extensive; extracorporeal; extramedullary; factors; failed; failure; family; family donor; faster; fatal; favorable; fdg; feam; feasibility; feasible; features; febrile; female patients; females; ferritin; fever; fewer patients; figure; filgrastim; filter; final; financial; findings; flow; flt3; fluconazole; fludarabine; fluid; fold; following; follows; form; fourth; fraction; free; free survival; frequency; frequent; fresenius; function; functioning; fungal; future; gastrointestinal; gcsf; gender; general; generation; generic; genes; germany; girl; global; globulin; goal; good; grade; grade ii; grading; graft; graft failure; graft patients; graftversus; granulocyte; greater; grfs; group; group patients; growth; guidelines; gut; gvhd; gvhd cases; gvhd grade; gvhd group; gvhd incidence; gvhd onset; gvhd patients; gvhd prevention; gvhd prophylaxis; gvhd pts; gvl; haematopoietic; half; hand; haploidentical; haploidentical donor; haploidentical hsct; haploidentical stem; haploidentical transplantation; haplosct; harvest; hazard; hcmv; hct; hdc; hdct; hdt; healing; healthy; help; hematological; hematological patients; hematology; hematopoiesis; hematopoietic cell; hematopoietic stem; hematopoietic transplantation; hemorrhagic; hepatic; hepatitis; herv; hhv-6; high; high dose; high incidence; high mortality; high rate; high relapse; high risk; higher; highest; histological; historical; history; hiv; hla; hlh; hlh patients; hma; hodgkin; home; honoraria; hospital; hospitalization; host disease; hpgv; hpl; hr =; hrt; hsct patients; hsct recipients; hsct setting; hsct treatment; hscts; hsos; hsv; human; hyperleukocytosis; hypertension; i.v; ibrutinib; icu; idelalisib; identification; ifd; ifn; igg; iii; il-2; il-6; image; imaging; imatinib; immediate; immune; immunity; immunodeficiency; immunoglobulin; immunological; immunomodulatory; immunosuppression; immunotherapy; impact; impaired; impairment; implementation; important; improved; improvement; incidence; incompatibility; increased; independent; index; indications; individual; induced; induction; infected; infection; inferior; inflammation; inflammatory; influence; information; informed; infusion; inhibitor; initial; initiation; injury; institute; institution; intensified; intensity; intensity conditioning; intensive; interactions; interest; intermediate; international; interval; intervention; intestinal; intestinal gvhd; intravenous; intravesical; introduced; introduction; invasive; investigation; involved; involvement; ips; iqr; iris; iron; irradiated; irradiation; isolated; issues; italy; itd; iv acute; january; japanese patients; july; june; kaplan; karnofsky; karyotype; kidney; killer; kinase; kinetics; kir; kit; knowledge; known; laboratory; lack; large; later; lead; leading; left; lenalidomide; length; lesions; leukaemia; leukapheresis; leukemia cells; leukemia patients; leukemias; leukemic; leukocyte; levels; lfs; life; ligands; light; like; likely; limitations; limited; line; line treatment; liposomal; literature; little; liver; load; local; logistic; london; long; longer; loss; lower; lung; lymphoblastic; lymphocyte; lymphoid; lymphoma patients; lymphomas; lymphoproliferative; m =; mac; main; maintenance; major; majority; males; malignancies; malignant; malignant disease; management; mann; mantle cell; march; marked; markers; marrow; marrow stem; marrow transplantation; mass; matched; matching; maternal; maximum; mcl; mdf; mds patients; mean; measurements; measures; mechanical; mechanism; median; median age; median cd34; median day; median disease; median dose; median duration; median follow; median hct; median interval; median neutrophil; median number; median os; median overall; median survival; median time; median total; medical; medicine; medium; meeting; meier; mel200; melphalan; memory; mesenchymal; mesenchymal stem; metabolic; method; methotrexate; methylprednisolone; mfd; micafungin; mice; microangiopathy; microbiota; micrornas; migration; mild; minimal; minimum; mir-21; mismatched; missing; mixed; mmf; mmud; mnc; mobilization; mobilizers; modality; model; moderate; modified; mofetil; molecular; moment; monitoring; monoclonal; monocytes; mononuclear; mononuclear cells; months; months post; morbidity; mortality; mouse; mpal patients; mpn; mps; mrd; mri; msc; mscs; msd; mtx; mucosal; mucositis; mud; mud hsct; multicenter; multiple; multivariate; muscle; mutated patients; mutation; mycophenolate; myeloablative; myeloablative conditioning; myelodysplastic; myelofibrosis patients; myeloid; myeloma patients; myeloproliferative; n =; naive; national; natural; nausea; necessary; need; negative; negative patients; neoplasm; nervous; neuroblastoma patients; neurological; neutropenia; neutropenic patients; neutrophil; new; newcastle; nhl; nih; nilotinib; nk cell; nkg2d; non; nonrelapse; normal; note; novel; november; novo; nrm; nucleated; number; nutritional; o0.0001; o0.05; o50; objective; observational; observed; obstruction; occlusive; occlusive disease; occurrence; october; ocular; old; older; oncology; oncology patients; ones; ongoing; onset; optimal; option; oral; organ; organization; origin; original; os p; outcome; outpatient; ovarian; overall; overall response; overall survival; overload; p =; p o0.001; p o0.05; p value; paediatric patients; pain; paneth cell; parameters; parents; partial; particular; party; past; pathogenesis; pathway; patient age; patients; patients alive; patients cd34; patients characteristics; patients median; patients post; patients relapse; pbmcs; pbsc; pcm patients; pcr; pediatric hsct; pediatric patients; peptide; percentage; performance; period; peripheral; peripheral blood; peripheral stem; persistent; pet; pfs; ph+; phase; phenotype; photopheresis; phsct; physical; physicians; picc; pirche; planned; plasma; plasma cell; platelet; platelet engraftment; platform; plerixafor; plt; plus; pneumonia; pnh; po0.01; points; polymerase; ponatinib; poor; poorer; population; positive; positive patients; positivity; possibility; possible; post; post hsct; post sct; post transplant; post treatment; posttransplantation; potential; practice; pre; predictive; predictor; preliminary; preparative; presence; present; presentation; pressure; pretransplant; pretreated; prevalence; prevention; previous; primary; priming; prior; probability; probable; problems; procedure; process; processing; product; profile; progenitor; progenitor cells; prognosis patients; prognostic; program; progression; proliferation; prolonged; promising; prompt; properties; prophylactic; prophylaxis patients; proportion; prospective; protein; protocol; proven; ptcy; ptld; ptld patients; pts; pubertal; pulmonary; purpose; qol; qpcr; quality; quantitative; questionnaire; rabbit; radiotherapy; randomized; range; rank; rapid; rare; rate; rbc; rdw; reaction; reactivation; reactive; reasons; receiving; recent; receptor; recipients; recommendations; reconstitution; records; recovered; recovery; recurrent; red cell; reduced; reduction; reference; refractory disease; refractory gvhd; refractory patients; reg3α; regimen; registry; regular; regulatory; rejection; relapse; relapse group; relapse incidence; relapse mortality; relapse post; relapse rate; relapse risk; related; relationship; relative; release; relevant; reliable; remaining; remission; renal; repeat; replacement; replete; reported; reporting; reports; required; research; residual; residual disease; resistant; resolution; respectively; respiratory; responders; responding; response; response rate; results; retrospective; retrospective study; review; rhtm; risk acute; risk factors; risk group; risk patients; risks; rituximab; role; room; routine; ruxolitinib; saa; safety; salvage; salvage patients; salvage treatment; samples; sanofi; scale; scan; scd; schedule; scheme; school; scid patients; sclerosis; score; screening; second; second hsct; second transplantation; secondary; secretion; selected; selection; self; sensitive; sensitivity; sepax; sepsis; september; septic; sequencing; sequential; series; serology; seronegative; seropositive; serotherapy; serum; setting; severe; severe acute; severe chronic; severe gvhd; severity; sex; sexual; shock; short; shorter; sibling; sickle cell; significant; significant risk; signs; similar; single; sinusoidal; sirolimus; site; situation; size; skin; small; social; society; software; sorafenib; sos; sources; special; specific; specificity; spectra; spectrum; spontaneous; st2; stable disease; stage; standard; standardized; starting; statistical; status; stay; stem cell; steroid; stimulating; stool; strategies; strategy; stratified; stromal; strong; studies; study; study group; subgroups; subjects; subpopulations; subsequent; subsets; substantial; subtype; successful; suffering; suitable; summary; superior; support; supportive; surface; surgery; surgical; surveillance; survey; survival; survival rate; survival time; survivors; sustained; symptomatic; symptoms; syndrome; syndrome patients; system; systemic; t cell; table; tacrolimus; taking; tam; tandem; target; targeted; tbf; tbi; tcd; tcr; team; technique; term; test; test p; testing; testosterone; th17; thalassemia; thalassemia patients; thalidomide; thawed; thawing; therapeutic; therapies; therapy; therapy patients; thiotepa; threatening; thrombocytopenia; thrombotic; thymocyte; thymoglobulin; times; timing; tissue; tki; tli; tma patients; tnc; tnf; tocilizumab; tolerance; topical; total; toxicities; toxicity; toxoplasmosis; tpoa; tract; training; transfusion; transient; transplant cyclophosphamide; transplant group; transplant gvhd; transplant outcomes; transplant patients; transplant treatment; transplantation group; transplantation outcomes; transplantations; transplanted; treating; treatment; treatment group; treatment option; treatment patients; treatment response; tregs; trend; treosulfan; trial; trm; tscm; tslp; tumor; type; typing; tyrosine; ucb; ucbt; ud patients; umbilical; unclear; undergone; underlying; understood; underwent; unit; univariate; universitario; university; unknown; unmanipulated; unrelated; unrelated donor; unrelated hsct; upfront; upper; urd; urine; usa; use; useful; vaccination; validation; value; variables; varied; variety; vegf; ventilation; versus; vgpr; viability; viable; viral; viremia; virus; vivo; vod; volume; voriconazole; washing; wbc; weekly; weeks; weight; white; whitney; withdrawal; women; work; working; world; worse; wound; wt1; year os; year overall; year relapse; year survival; years; years old; years post; yield; younger patients; yrs
    • versions: original; plain text
14. cord-005478-5iu38pr6
    • author: None
    • title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Oral Session
    • date: 2019-07-03
    • words: 63536
    • flesch: 53
    • summary: Commonly reported AEs (≥20% patients) were URTI, AST/ALT elevations, fatigue, nausea and diarrhea. %]) attributed to injection site-related TEAEs.
    • keywords: /kg; 0.001; 1,2; 95%ci; aba; abnormalities; abstract; active; activity; acute; acute gvhd; additional; adult; adult patients; advanced; adverse; aes; age; aged; aim; alive; allogeneic; allosct; alternative; amgen; aml; aml patients; analysis; anemia; anti; antibodies; antibody; antigen; applied; approach; arm; asct; asp0113; assays; assessment; associated; association; asxl1; atg; auc; authors; autologous; available; azacitidine; background; baseline; bcma; bcv; benefit; best; better; blood; bmf; bone; burden; busulfan; car; car t; care; cases; cause; cd19; cd34; cd4; cd8; cell; cell therapy; cell transplantation; cellular; centers; changes; characteristics; chemotherapy; children; chimeric; chimerism; chromosome; chronic; chronic gvhd; cibmtr; cik; cir; clarac; clinical; clones; cmv; cns; cohort; combination; combined; common; comparable; complement; complete; complications; conclusions; conditioning; consecutive; consecutive patients; control; conventional; cord; count; course; cox; cr1; cr2; criteria; crs; cryopreserved; csa; csf; cumulative; curative; current; cycles; cyclophosphamide; cyclosporine; cytogenetic; cytokine; cytometry; data; date; days; death; december; depletion; detectable; determined; development; diagnosis; differences; different; dipss; disclosure; disease; disease relapse; dna; donor; dose; dpb1; drug; duration; dysfunction; early; easix; ebmt; effective; effects; efficacy; eligible; endothelial; endpoint; engraftment; erbb2; european; evaluated; events; evidence; expansion; experience; expression; extensive; factors; failure; figure; findings; flamsa; flow; fludarabine; follow; following; free; free survival; frequent; fresh; function; funding; generation; globulin; good; grade; graft; grfs; group; gvhd; gvl; haplo; haploidentical; hazard; hct; hematologic; hematopoietic; hematopoietic stem; high; high risk; higher; history; hla; honoraria; hospital; host; hscs; hsct; human; hyperbilirubinaemia; ibd; ifd; ifn; igg; iii; image; immune; immunosuppressive; immunotherapy; impact; important; improved; improvement; incidence; increase; independent; index; individual; induction; infection; inflammatory; infusion; inherited; inhibitors; intensity; interest; intermediate; iqr; irradiation; january; jazz; karnofsky; kd025; killer; known; label; large; later; lentiglobin; lentiviral; leukemia; leukemia patients; levels; lfs; life; limited; line; liver; long; lower; lymphoblastic; lymphocyte; lymphoid; lymphoma; mac; main; major; majority; male; malignancies; malignant; markers; marrow; matched; mds; mean; median; median age; median follow; median time; medical; memory; methods; mfc; mice; minimal; mismatched; mll; mmf; mobilization; model; moderate; modified; mofetil; molecular; months; morbidity; mortality; mrd; msd; mud; multicenter; multiple; multivariate; murine; mutation; myc; mycophenolate; myeloablative; myelofibrosis; myeloid; myeloma; n=1; n=3; negative; neutropenia; neutrophil; nhl; nkg2dl; non; novartis; novel; nrm; number; objective; observation; observed; older; ongoing; onset; option; organ; orr; outcome; overall; overall survival; p=0.001; p=0.02; partial; patients; pbsc; pcr; pediatric; pediatric patients; performance; period; peripheral; pfs; pharma; phase; placebo; plasma; platelet; plus; points; poor; population; positive; post; posttransplant; potential; pre; present; previous; primary; prior; procedure; process; production; products; profile; progenitors; prognostic; progression; prophylaxis; proportion; prospective; protein; protocol; ptcy; pts; pulmonary; quality; randomized; range; rare; rate; ratio; reactivation; recent; receptor; recipients; recombinant; reconstitution; recovery; reduced; refractory; regimen; registry; regulatory; relapse; relapse mortality; relapse patients; related; release; remission; renal; reported; research; residual; responders; response; restricted; results; retrospective; ric; risk; risk patients; role; ruxolitinib; safety; samples; score; second; secondary; selected; serum; setting; severe; sex; short; sibling; significant; similar; single; sirolimus; skin; sos; source; specific; standard; status; stem; stem cell; steroid; strategies; strategy; studies; study; subjects; substitution; support; survival; survivors; sustained; symptoms; syndrome; system; t cell; table; target; tbf; tbi; tcr; term; test; thalassemia; therapeutic; therapies; therapy; thiotepa; thrombocytopenia; thymic; time; tki; tma; total; toxicity; transduced; transfusions; transplant; transplantation; treatment; treg; trial; trm; tumor; type; underwent; univariate; university; unrelated; use; vaccine; validation; value; variables; vector; viral; vivo; vod; weeks; years
    • versions: original; plain text
15. cord-005480-yg7salqt
    • author: None
    • title: Oral Sessions and Working Party
    • date: 2008-03-26
    • words: 72763
    • flesch: 51
    • summary: Therefore, we compared BM versus PB in patients patients transplanted after 1994: 1226 patients received BM and 4605 PB. Since transplantation patients were treated only with symptomatic therapy.
    • keywords: 1st; 2nd; 95%ci; absence; activation; activity; acute; acute gvhd; addition; adjusted; administration; adult; adult patients; advanced; adverse; age; aid; aim; alive; allogeneic; allogeneic hsct; allogeneic stem; allogeneic transplantation; allografting; allohsct; alloreactive; alloreactivity; alternative; alwp; aml; aml patients; analysis; anemia; anti; antibodies; antibody; antigen; approach; arm; arthritis; asct; assessment; associated; association; atg; auc; autoimmune; autologous; autologous stem; autologous transplantation; available; background; basis; beam; behalf; benefit; better; biopsies; blood; blood stem; blood transplantation; body; bone; busulfan; cancer; card15; cases; cause; cd34; cd4; cd8; cell; cell depletion; cell dose; cell source; cell transplantation; center; centres; characteristics; chemosensitive; chemotherapy; children; chimerism; chronic; chronic gvhd; clinical; cll; clones; cml; cmv; cohort; combination; common; comparison; complete; complex; complications; conclusion; conditioning; conditioning regimen; conditions; consecutive; consecutive patients; contrast; control; conventional; cord; countries; counts; course; cr1; cr2; criteria; csa; csf; culture; cumulative; curative; cure; current; cyclophosphamide; cyclosporine; cytogenetics; daily; data; date; day+7; days; death; december; decrease; depletion; determined; development; dfo; dfs; diagnosis; differences; different; disease; disease relapse; dli; donor; donor cell; donor t; dose; double; dpb1; drug; duration; early; ebmt; ebv; effect; effective; effector; efficacy; efs; eligible; endpoint; engraftment; episodes; established; evaluable; evaluation; event; evidence; expansion; experience; expression; extensive; factors; failure; family; feasibility; feasible; features; female; ferritin; fibrosis; findings; flt3; fludarabine; fold; follow; foxp3; free; free survival; frequent; function; gender; general; generation; genes; genetic; goal; good; grade; graft; group; gvhd; gvhd prophylaxis; gvl; gvt; haplo; haploidentical; hct; hdc; hdm; hdt; health; hematological; hematopoietic; hematopoietic stem; high; high risk; higher; hla; hodgkin; hospital; host; host disease; hsct; hsct patients; human; ibmi; icu; identical; iii; il-2; imatinib; immune; immunosuppressive; immunotherapy; impact; impairment; important; improved; improvement; incidence; increase; independent; index; indexes; indications; induction; infection; inferior; influence; information; infused; infusion; initial; intensity; intensive; intermediate; international; interval; introduction; involved; irradiation; isolated; itd; january; june; karyotype; kidney; kir; large; later; lc30; lead; leukemia; levels; lfs; likely; limited; line; liver; lmp2; load; local; long; loss; lower; lung; lymphocytes; lymphoid; lymphoma; mac; main; major; majority; malignancies; malignant; marrow; marrow transplantation; matched; matching; mds; mean; median; median age; median cell; median follow; median time; medical; meeting; melphalan; memory; mesenchymal; metastatic; methods; methotrexate; mice; miha; minimal; mismatched; mixed; mmf; mmp; mobilization; model; modified; molecular; monitoring; mononuclear; months; morbidity; mortality; mrd; msc; mscs; mt1; mucositis; mud; multicenter; multiple; multivariate; mutation; myeloablative; myeloid; myeloma; myeloma patients; n=1; n=2; n=4; need; negative; neutropenia; neutrophil; new; nhl; nod2; non; normal; novel; nrm; number; objective; observed; occurrence; older; ongoing; option; oral; organ; outcome; overall; overall survival; oxygen; p<0.001; p=0.05; pairs; parameters; partial; party; patients; patients patients; pbsc; pcr; pd-1; pediatric; percentage; period; peripheral; persistent; pet; pfs; phase; physical; physicians; platelet; pll; plus; poor; population; positive; possible; post; potential; pp65; pre; predictive; preliminary; presence; present; pretransplant; previous; primary; prior; probability; procedure; products; progenitors; prognosis; progression; proliferation; promising; properties; prophylaxis; proportion; prospective; protein; protocols; pts; quality; questionnaire; randomized; range; rapid; rate; rcc; recent; receptor; recipients; reck; reconstitution; recovery; reduced; reduction; refractory; regimen; registration; registry; regulatory; rejection; relapse; relapse mortality; relapse risk; remission; renal; report; residual; response; results; retrospective; ric; risk; risk factors; risk patients; rituximab; role; safety; samples; scan; score; search; second; secondary; selection; sepsis; series; setting; severe; severity; sex; sexual; short; sibling; significant; similar; single; sirolimus; sirolimus patients; skin; sle; snp; source; specific; ssc patients; stable; stage; standard; start; status; stem cell; stimulated; stimulation; strategies; strategy; studies; study; subcommittee; subsequent; summary; superior; surveillance; survey; survival; survivors; sustained; syndrome; system; t cells; target; tbi; tcr; term; test; therapeutic; therapies; therapy; time; total; toxicity; transplant patients; transplantation; transplanted; treatment; tregs; trend; treo; trial; trm; tumor; tumours; type; typing; ucbt; umbilical; underwent; unit; univariate; university; unknown; unrelated; unrelated donor; update; use; vaccination; vaccine; values; variables; versus; viral; vitro; vod; vs.; weeks; wt1; x10; years; yrs; zuc3
    • versions: original; plain text
16. cord-005487-vac061r8
    • author: None
    • title: Physicians Abstracts: EBMT 2010
    • date: 2010-04-07
    • words: 59087
    • flesch: 53
    • summary: Introduction: Development of leukemia or myelodysplasia derived from donor cells termed donor cell leukemia (DCL) is a rare but severe complication following allogeneic hematopoietic transplantation. Conclusion: The answers to these questions will help to further characterize donor cell derived leukemia and provide new insights into leukemogenesis in general.
    • keywords: 2nd; 95%ci; abnormalities; absence; activation; active; activity; acute; acute gvhd; addition; adoptive; adults; advanced; adverse; age; aged; aim; alive; allele; allogeneic; allogeneic hsct; allogeneic stem; allogeneic transplantation; alloreactive; allosct; alpha; alternative; aml; aml patients; ammatory; analysis; antigen; applied; approach; arms; asct; assessment; associated; atg; autoimmune; autologous; available; b cells; background; balb; benefi; best; better; blasts; blood; body; bone; brosis; busulfan; c t; cacy; care; cases; cd19; cd34; cd4; cd40; cd56; cd8; cell dose; cell transplantation; cells; centers; centres; characteristics; characterized; chemotherapy; children; chimerism; chronic; chronic gvhd; ciency; cient; cik; class; clinical; cml; cmv; cohort; collected; collection; combination; common; comparable; comparison; complete; complication; conclusion; conditioning; conditions; confi; contrast; control; conventional; cord; countries; cox; cr1; cr2; criteria; csa; csf; ctl; culture; cumulative; current; cyclophosphamide; cyclosporine; cytogenetics; cytokine; cytotoxic; data; days; death; defi; depletion; described; development; diagnosis; differences; different; disease; dli; dna; donation; donor; donor cell; donor t; dose; double; drb1; duration; early; ebmt; ebv; ecfcs; effect; effective; effector; effi; efs; elderly; elevated; endothelial; engraftment; evaluable; evaluation; events; evidence; expansion; experience; expression; extensive; factors; failure; family; feasible; female; fev1; fi rst; figure; flt3; fold; follow; following; free; frequent; functional; future; genes; grade; graft; group; gvhd; gvl; haploidentical; hct; hct2; hematological; hematopoietic; hematopoietic stem; hhv6; high; high risk; higher; hla; host; hr =; hsct; human; identical; identifi; ifn; igg; iii; immune; immunity; immunosuppression; immunotherapy; impact; important; improved; improvement; incidence; increased; independent; induced; induction; infection; infl; infusion; innate; insulin; intensity; interval; introduction; involvement; itd; karyotype; lack; large; leukemia; levels; lfs; like; limited; line; liver; long; lower; lung; lymphocytes; lymphoma; main; major; majority; male; malignancies; malignant; management; markers; marrow; matched; mds; mean; median; median age; median follow; median time; melphalan; memory; methods; mice; mismatched; mmf; mobilization; model; molecular; months; mortality; mrd; mscs; mtx; mud; multiple; multivariate; myeloablative; myeloid; myeloma; n =; naïve; ned; need; negative; neutrophil; new; nk cells; nkt; non; normal; novel; nrm; number; objective; observed; ongoing; option; order; organ; outcome; overall; overall survival; p =; p<0.001; p<0.05; parameters; partial; patients; pattern; pbsc; pdc; pediatric; peptide; period; peripheral; pfs; phase; phenotype; placebo; plus; poor; population; positive; possible; post; potential; presence; present; previous; primary; prior; probability; procedure; process; prochymal; progenitor; prognostic; progression; proliferation; prophylaxis; prospective; protocol; pts; purifi; quality; randomized; range; rate; receptor; recipients; reconstitution; recovery; reduced; refractory; regimen; registry; rejection; relapse; relapse incidence; relapse mortality; related; remission; repertoire; report; response; results; retrospective; ric; ricallo; rict; risk; risk patients; role; rst; safety; salvage; saml; samples; scm; score; sct patients; second; secondary; selection; serum; setting; severe; sibling; signifi; similar; single; skin; small; source; specifi; specifi c; stable; stage; standard; status; stem; stem cell; strategies; strategy; studies; study; subsets; summary; support; survey; survival; sustained; syndrome; system; systemic; t cells; tandem; target; tbi; tcr; term; test; thalassemia; therapeutic; therapies; therapy; time; tissues; total; toxicity; tprec; transfer; transplantation; transplanted; treatment; trend; treosulfan; trial; trm; tumor; type; ucbt; udarabine; uence; underwent; unrelated; use; velcade; viral; virus; vitro; vivo; vod; vs.; vtd; weeks; years; younger; yrs
    • versions: original; plain text
17. cord-005794-3u4iu41r
    • author: Berner, Michel E.
    • title: High frequency oscillatory ventilation for respiratory failure due to RSV bronchiolitis
    • date: 2008-05-24
    • words: 2147
    • flesch: 40
    • summary: RSV induced respiratory failure with hypercapnia can be managed with HFOV using high mean airway pressure and large pressure swings while preserving spontaneous breathing. aw pressure, peak to peak amplitude, ventilatory frequency, I:E ratio), blood gases and vital signs (infants respiratory rate, mean arterial blood pressure and heart rate) were extracted during conventional mechanical ventilation (period CMV), a mean of 3 h (±40 min) after the switch to HFOV (period HFOVi), mid course (period HFOVm), just prior stopping HFOV (period HFOVe) and after extubation either on CPAP and/or supplemental oxygen therapy (Post-Extub).
    • keywords: airway; blood; bronchiolitis; cmv; conventional; course; cpap; disease; failure; frequency; hfov; high; infants; infection; lung; mean; mechanical; obstructive; oscillatory; oxygen; pattern; peak; period; pressure; rate; respiratory; rsv; settings; small; supplemental; support; ventilation; ventilatory
    • versions: original; plain text
18. cord-006393-jcj9nqfu
    • author: Tutschka, Peter J.
    • title: The use of immunoglobulin in bone marrow transplantation
    • date: 1990
    • words: 3399
    • flesch: 42
    • summary: Bone marrow transplantation for leukemia following a new busuIfan and cyclophosphamide regimen Graft versus host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings: Beneficial effect of a protective environment Clinical Use of Intravenous Immunoglobulins Antibody therapy in gram-negative bacterial disease The role of microflora in development of graft versus host disease Graftvs-host disease and sialodacryoadenitis viral infection in bone marrow transplanted rats Cytomegalovirus (CMV) infection in bone marrow transplant recipients: On the other hand, autologous transplantation patients might provide an excellent target population in which to study more nonspecific effects, such as the reduction of infections during aplasia, because we do not have the compounding variables of GVHD, immune modulation phases, and so on.
    • keywords: antibodies; bone; cells; cmv; complications; deficiency; disease; donor; dose; effective; function; gastroenteritis; globulin; graft; gram; group; gvhd; hemorrhagic; host; igg; immune; important; incidence; infections; interstitial; ivig; marrow; number; patients; phase; pneumonia; recipients; seronegative; seropositive; severe; studies; study; subclass; system; therapy; transplantation; use; viral
    • versions: original; plain text
19. cord-006466-e1phpqes
    • author: None
    • title: 2018 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference
    • date: 2018-04-23
    • words: 92405
    • flesch: 42
    • summary: Despite defective T cell signaling responses to chemokines (i.e., GPCR stimulation), chemotaxis of patient T cell blasts in vitro was normal. Proteasome assembly and catalytic function was assessed by SDS-PAGE and native gel respectively, using patient derived cell lines.
    • keywords: abdominal; abnormal; abnormalities; abscesses; absence; absent; absolute; acid; activation; activity; acute; ada; ada2; addition; additional patients; adequate; adhesion; administration; admission; adult; adult patients; adverse; affected; age; aim; allele; allergic; allergy; allogeneic; alps; alternative; amino; analysis; anemia; antibiotics; antibodies; antibody; antigens; apoptosis; approach; appropriate; arthritis; assay; assessment; associated; association; asthma; atopic; atopy; atypical; autoantibodies; autoimmune; autoimmunity; autoinflammation; autosomal; available; average; awareness; b cells; background; bacterial; bal; baseline; bcg; benefit; beta; better; bilateral; binding; biochemical; biopsies; biopsy; birth; blood; bmt; bone; booster; bowel; boy; broad; bronchiectasis; btk; burst; busulfan; canadian; cancer; card11; cardiac; care; carriers; case; causative; cd160; cd18; cd19; cd3; cd4; cd40l; cd45; cd45ra; cd8; cd8 t; celiac; cell counts; cell deficiency; cell development; cell function; cell immunodeficiency; cell lymphopenia; cell proliferation; cell receptor; cell reconstitution; cell repertoire; cell subsets; cell transplantation; cellular; centers; central; cgd; chain; challenges; changes; characteristics; characterization; characterized; chart; chest; chh; childhood; children; chimerism; chronic; circles; class; clinical; clinical phenotype; cmc; cmv; codon; cohort; colitis; combination; combined; combined immunodeficiency; common; comparable; complement; complete; complex; complicated; complications; compound; concentrations; conclusions; conditioning; conditions; congenital; consistent; continued; control; copies; cord; correlation; cost; cough; counts; course; criteria; cross; crucial; ctla-4; ctla4; culture; curative; cutaneous; cvid patients; cybb; cytokine; cytometry; cytopenias; cytotoxic; data; database; day; days; decreased; defective; defects; deficiencies; deficient; deficient patients; delay; delayed; deletion; dermatitis; detection; developed; development; dhr; diabetes; diagnosis; diarrhea; differences; different; differential; differentiation; difficult; disease; disorders; distinct; distribution; dna; dock8; domain; dominant; donor; dose; drug; dysfunction; dysregulation; earlier; early; ebv; eczema; editing; effective; effector; effects; efficacy; elevated; encoding; engraftment; enteropathy; eosinophilia; episodes; epithelial; essential; established; evaluation; evans; events; evidence; examination; excision; exome; exon; expansion; experience; expression; extensive; factor; failure; families; family; fatigue; features; female; feno; ferritin; fever; findings; flow; following; form; foxn1; foxp3; frequency; frequent; function; fungal; future; gain; gastrointestinal; gata2; gene; gene therapy; generalized; generation; genetic; genome; genomic; genotype; girl; good; granulomas; granulomatous; greater; group; gvhd; h2ax; half; haploidentical; haploinsufficiency; hct; healthy; hematologic; hematopoietic; hematopoietic cell; hemolytic; hepatitis; heterogeneous; heterozygous; hies patients; high; higher; highly; history; hiv; hizentra; hla; hlh; home; homozygous; hospital; hospitalization; hsct; human; humoral; hyper; hypogammaglobulinemia; hypomorphic; ibd; identification; idiopathic; ifn; ifnγ; iga; ige; igg; igg levels; igg4; iggsc; igm; igrt; ikbkb; il-17; il-2; il2rg; imaging; immune; immune cell; immune deficiency; immune dysregulation; immune system; immunization; immunodeficiency; immunodeficiency disease; immunodeficiency patients; immunoglobulin; immunological; immunology; impact; impaired; important; improved; improvement; incidence; increased; individuals; induced; infancy; infants; infections; inflammation; inflammatory; influenza; information; infusions; inhibitory; initial; initiation; innate; institute; institution; intensity; interferon; intermittent; interstitial; intracellular; intravenous; introduction; invasive; investigation; involvement; ipex; irradiation; isolated; isolation; itp; ivig; january; kinase; knowledge; known; laboratory; lack; lad; large; lead; left; lesions; leukemia; levels; life; like; likely; limited; literature; little; liver; long; loss; low; low b; low igg; lower; lung; lung disease; lupus; lymphadenopathy; lymphocyte; lymphoid; lymphoma; lymphopenia; lymphoproliferative; majority; male; male patients; malignancies; malignancy; management; manifestations; marked; markers; marrow; mass; matched; maternal; maturation; mature; mbl; mcl; mean; measurement; mechanism; median; medical; medications; medicine; mellitus; memory; memory b; methods; mice; mild; missense; mitogen; mm3; models; molecular; monocytes; months; mortality; mother; mouse; mri; multiple; mutant; mutation; mycobacterial; myeloid; n=1; n=2; n=3; national; natural; naïve; naïve t; nbs; ncf1; negative; neurological; neutropenia; neutrophil; newborn; niaid; nih; nk cells; non; nonsense; normal; normal t; notable; novel; nu/+; number; objectives; observed; oit; old; older; ongoing; onset; option; organ; organism; origin; otitis; outcomes; overall; oxidase; oxide; p22phox; p47phox; pain; panel; parameters; parents; partial; pathogenic; pathway; patients; pattern; pbmcs; pcr; pediatric; pediatric patients; percentage; period; peripheral; persistent; phase; phd; phenotype; phenotyping; phosphorylation; physical; physicians; pid; pidd; pidd patients; pids; pidtc; plasma; plasma cells; platelet; pneumococcal; pneumonia; pneumovax; pnp; point; polysaccharide; poor; population; position; positive; possible; post; potential; ppsv23; pregnancy; presence; present; presentation; presenting; prevalence; previous; primary; primary immune; primary immunodeficiency; prior; proband; process; production; professor; profile; profound; prognosis; progressive; proliferation; prolonged; prominent; prophylactic; prophylaxis; proportion; protamine; protective; protein; protocol; pts; pulmonary; qol; quality; quantification; rag1; range; rapid; rare; rash; rate; reactions; reactive; recent; receptor; recessive; recipients; reconstitution; records; recurrent; recurrent infections; reduced; reference; refractory; regimen; region; regulatory; related; renal; repair; repeat; repertoire; replacement; reported; reports; research; residual; respiratory; responders; response; results; retrospective; review; right; risk; rituximab; role; routine; rubella; safety; samples; sanger; scid; scid patients; scig; scores; screening; second; secondary; selection; selective; sensitivity; sepsis; sequence; sequencing; series; serotypes; serum; setting; severe; severe infections; severe t; severity; shingles; short; showing; signaling; significant; signs; similar; single; sinopulmonary; sinus; sinusitis; sister; site; skin; skin infections; small; somatic; species; specific; spectrum; splenomegaly; splice; staining; standard; starting; stat3; statistical; status; stem; stem cell; steroids; stimulated; stimulation; studies; study; subcutaneous; subjects; submission; subsequent; subsets; substitution; successful; suggestive; support; surgery; survival; susceptibility; suspicion; switched; symptomatic; symptoms; syndrome; system; systemic; t cells; t lymphocytes; targeted; tcr; term; tested; testing; tests; tetanus; therapeutic; therapies; therapy; thi; threatening; thrombocytopenia; throughput; thymectomy; thymic; thymus; time; tissue; titers; tool; total; tract; transcription; transplant; transplant patients; transplantation; treatment; trec; treg; trial; trough; types; ucbt; umbilical; underlying; understanding; underwent; undetectable; unique; university; unknown; unrelated; upper; use; utility; vaccination; vaccine; values; variable; variant; vascular; viral; viremia; virus; vitro; vs.; weekly; weeks; weight; wes; wide; wild; women; work; workup; worsening; xiap; xla; years; years old; yield; young
    • versions: original; plain text
20. cord-006586-49btg9w7
    • author: Golfieri, R.
    • title: Pulmonary complications of liver transplantation: radiological appearance and statistical evaluation of risk factors in 300 cases
    • date: 2000
    • words: 7782
    • flesch: 34
    • summary: In addition, a highly significant correlation (p < 0.001) was observed between pneumonia-risk score and the expected survival, thus confirming pulmonary infections as a major cause of death in OLT recipients. The following clinical data were recorded and correlated to the onset of pulmonary infections and to the outcome: 1.
    • keywords: abnormalities; agents; alveolar; amv; analysis; anastomosis; appearance; ards; atelectasis; bacterial; candida; cases; caval; chest; clinical; cmv; complications; consolidation; correlation; course; cxr; days; different; diffuse; early; effusion; factors; fatal; follow; fungal; high; higher; icu; incidence; infections; infiltrates; interstitial; liver; lung; majority; month; mortality; multivariate; non; oedema; okt3; olt; onset; orthotopic; outcome; pathogens; patients; pattern; period; pleural; pneumonia; population; postoperative; posttransplant; present; prolonged; pulmonary; pulmonary infections; pulmonary oedema; radiographic; radiological; rate; recipients; risk; risk factors; risk score; score; series; severe; significant; statistical; stay; study; surgical; survival; table; therapy; time; transplantation; type; univariate; viral
    • versions: original; plain text
21. cord-006713-io9yp1y2
    • author: Wrede, C. E.
    • title: Intensivmedizinische Betreuung von Patienten nach Stammzelltransplantation
    • date: 2007
    • words: 5259
    • flesch: 24
    • summary: Bei Auftreten einer stärkeren hämorrhagischen Cystitis stehen therapeutisch die Verbesserung der Gerinnung, z. B. durch Thrombozytengabe, die Verhinderung der Blasentamponade und Ureterverlegung durch Die wichtigste Differentialdiagnose der infektiösen Gastroenteritis stellt die intestinale GvHD dar
    • keywords: abb; aber; acute; adenoviren; adäquate; akuten; allem; allogeneic; als; aspergillus; auch; auf; aufgrund; auftreten; aus; bal; behandlung; bei; beschrieben; besteht; beteiligung; bis; blood; bone; candida; cardiac; care; cell; cell transplantation; cerebrale; cmv; complications; dar; das; dass; dazu; dem; der; des; deutlich; diagnostik; diagnostische; die; diese; diffuse; disease; durch; eher; eine; einerseits; eingesetzt; einhergeht; einsatz; engraftment; erfolgen; erkrankung; erreger; ersten; extrem; failure; frühzeitigen; führen; für; gabe; gastrointestinal; gerade; grund; gvhd; haben; hat; hematologic; hematopoietic; hematopoietic stem; hepatic; heute; hhv6; hier; high; hla; host; hsv; häufig; häufiger; häufigste; immer; immunabwehr; immunologischen; infectious; infektionen; influenza; innerhalb; insbesondere; insuffizienz; intensive; intensivmedizinische; intervention; intestinale; invasive; ist; jahre; kann; kommt; komplikationen; konnte; können; leber; lunge; marrow; maßnahmen; mehrzahl; meist; mit; monate; mortalität; muss; müssen; nach; nachweis; neben; neurological; neutropenie; neutrophilen; nicht; nur; occlusive; oder; organ; outcome; parainfluenza; pathophysiologie; patienten; patients; phase; pilzinfektionen; pneumonie; post; pre; prognose; prophylaxe; pulmonale; rahmen; reaktionen; recipients; reduziert; regel; renal; respiratorische; risiko; rsv; schweren; sct; sein; selten; sepsis; sich; sie; sind; sollte; sowie; specific; spezifische; stages; stammzellen; stammzelltransplantation; stehen; stellen; stellt; stem; stem cell; syndrom; szt; tagen; therapie; therapieverfahren; therapy; transplantation; transplantierten; treatment; typische; und; unter; veno; verlauf; veränderungen; virale; viren; vod; von; vor; vordergrund; vzv; weitere; werden; wie; wird; wobei; wurde; während; wässerung; zeitraum; zum; zunächst; zur; zwischen; über
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22. cord-006841-3u56erru
    • author: Einsele, Hermann
    • title: Infectious complications after allogeneic stem cell transplantation: epidemiology and interventional therapy strategies: Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)
    • date: 2003-09-10
    • words: 5276
    • flesch: 30
    • summary: key: cord-006841-3u56erru authors: Einsele, Hermann; Bertz, Hartmut; Beyer, Jörg; Kiehl, Michael G.; Runde, Volker; Kolb, Hans-Jochen; Holler, Ernst; Beck, Robert; Schwerdfeger, Rainer; Schumacher, Ulrike; Hebart, Holger; Martin, Hans; Kienast, Joachim; Ullmann, Andrew J.; Maschmeyer, Georg; Krüger, William; Niederwieser, Dietger; Link, Hartmut; Schmidt, Christian A.; Oettle, Helmut; Klingebiel, Thomas title: Infectious complications after allogeneic stem cell transplantation: epidemiology and interventional therapy strategies: Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) date: 2003-09-10 journal: The risk of infection after allogeneic stem cell transplantation is determined by the underlying disease, the intensity of previous treatments and complications that may have occurred during that time, but above all, the risk of infection is determined by the selected transplantation modality (e.g. HLA-match between the stem cell donor and recipient, T cell depletion of the graft, and others).
    • keywords: aciclovir; adenovirus; allogeneic; allogeneic stem; amphotericin; bacteremias; blood; bone; case; cell; cell transplantation; clinical; cmv; day; diagnostic; disease; documented; donor; e.g.; early; ebv; empiric; engraftment; factors; fever; fungal; gram; gvhd; hematopoietic; high; hsv; incidence; infections; initial; invasive; late; lymphoproliferative; manifestations; marrow; mortality; neutropenic; pathogens; patients; period; pneumonia; post; procedures; prophylaxis; pulmonary; rate; reactivation; recipients; reconstitution; respiratory; risk; severe; spectrum; stem; stem cell; systemic; table; techniques; therapy; transplantation; treatment; virus; vzv
    • versions: original; plain text
23. cord-006856-b1w25ob5
    • author: None
    • title: 19th Meeting of the Austrian Society of Transplantation, Transfusion, and Genetics, October 26–28, 2005
    • date: 2005
    • words: 29728
    • flesch: 49
    • summary: The average serum creatinine after 5 years is 153.56 ± 24.65 µmol/l. Cumulative graft survival after 5 years is shown by Kaplan-Meier curve: graft survival, 75.1%; patients survival, 83.9%; graft and patients survival, 67.1%. Extracorporeal photopheresis has been shown to be beneficial in acute and chronic rejection in heart transplant patients and has also been used in lung transplant recipients with acute rejection or bronchiolitis obliterans. Methods.
    • keywords: abdominal; activation; activity; acute; addition; age; aim; alive; allogeneic; allograft; als; aml; analyse; analysis; anti; antibody; antigen; artery; ascites; assay; atg; auf; aus; autologous; average; background; bacterial; balb; basis; bei; biopsy; bleeding; blockade; blood; bmt; bnp; bone; bos; bronchial; c4d; c57bl/6; cancer; candida; cardiac; cardiomyocytes; cases; cd25; cd3; cd4; cells; cellular; center; chimerism; cholestatic; chronic; cirrhosis; clearance; clinical; cmv; cohort; cold; collection; combination; combined; common; comparable; comparison; complete; complications; conclusions; conditioning; consecutive; continuous; contrast; control; course; creatinine; criteria; csa; csf; ctla4ig; cuff; cumulative; cyclosporine; cytotect; das; data; day; days; dcm; dcs; death; decrease; dependent; der; des; diagnosis; die; dieser; different; disease; disorders; dna; donation; donor; dose; drug; dst; dysfunction; early; ecmo; effect; eine; end; episodes; ergebnisse; established; events; everolimus; excellent; expression; extended; factor; failure; female; fibrosis; follow; following; fty720; function; fungal; für; gcm; genotype; gms; good; grade; graft; graft survival; group; growth; gruppe; gvhd; h-2; hbcab; hbig; hbv; hcc; hcv; heart; hepatitis; high; higher; hl-1; ho-1; hplc; hsct; htx; human; iii; immunosuppression; impact; implantation; important; incidence; increase; induction; infection; inflammation; inhibitor; innsbruck; institution; intra; ischemia; islet; isolated; isolation; kaplan; kidney; left; levels; like; lipocalin-2; list; liver; living; long; loss; lower; lung; lung transplantation; lymphoma; majority; male; mapk; marginal; marrow; mars; mean; median; medical; meier; meld; methods; mice; microscopy; min; mit; mixed; model; moderate; mofetil; monitoring; months; mortality; multiple; mycophenolate; myeloablative; myocardial; n =; nach; negative; neoplasms; new; nicht; non; normal; number; observation; observed; organ; outcome; overall; p =; p38; pancreas; pancreatic; pap; parameters; particular; pathogens; patient survival; patienten; patients; pbsc; pcr; period; peripheral; phosphorylation; platelet; plb; population; positive; post; postoperative; posttransplant; potential; preoperative; preservation; primary; prior; probability; procedure; progression; proliferation; prophylaxis; protein; proteinuria; protocol; ptld; pts; pulmonary; quality; range; rate; ratg; ratio; recipients; recurrence; reduced; reduction; regimen; rejection; relapse; related; remission; renal; reperfusion; report; response; results; retrospective; ric; risk; role; s1p; sample; schlussfolgerungen; score; sepsis; serum; severe; sex; short; sich; significant; similar; sirolimus; skin; slpi; small; solid; solutions; specific; srl; stable; stage; standard; stem; stent; steroids; stimulation; studiengruppe; studies; study; substantial; suffering; surgical; survival; switch; system; tacrolimus; tbi; technique; term; test; tgf; therapeutic; therapy; time; tissue; tolerance; total; transplant patients; transplantation; transplanted; treatment; trm; tumor; type; underwent; university; unrelated; urine; use; values; vascular; vegf; venous; ventricular; vitro; vivo; von; waiting; war; weeks; werden; wien; wurde; years; zellen
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24. cord-007575-5ekgabx5
    • author: Luby, James P.
    • title: Southwestern Internal Medicine Conference: Pneumonias in Adults Due to Mycoplasma, Chlamydiae, and Viruses
    • date: 2016-01-14
    • words: 12010
    • flesch: 36
    • summary: Clinically, the patient with influenza virus pneumonia has the sudden onset off ever, prostration, and myalgias followed shortly by dyspnea. Influenza virus pneumonia occurred during hospitalization.
    • keywords: acute; acyclovir; adenovirus; administration; admission; adults; age; alveolar; antibiotic; antibody; antigen; associated; atypical; bacterial; blood; bone; cases; cause; cells; chest; children; chlamydia; clinical; cmv; common; community; complement; complicated; consolidation; cough; count; course; cytomegalovirus; days; development; diagnosis; diffuse; disease; dose; drug; dysfunction; dyspnea; effective; epidemic; erythromycin; etiology; evidence; examination; failure; fatal; fever; figure; fixation; group; hepatic; high; hospital; hospitalization; human; illness; immunosuppressed; infection; infiltrates; inflammatory; influenza; influenza pneumonia; interstitial; involvement; like; lobar; lower; lung; major; manifestations; marrow; measles; medical; microorganisms; mild; military; mycoplasma; mycoplasma pneumonia; nonbacterial; normal; oral; parainfluenza; patients; persons; pharyngitis; physical; pleural; pneumococcal; pneumonia; presence; present; primary; process; psittaci; pulmonary; radiograph; rash; recipients; renal; respiratory; ribavirin; rsv; rubeola; serologic; severe; specific; sputum; strain; study; suprainfection; syncytial; syndrome; temperature; test; tetracycline; therapy; time; trachomatis; tract; transplant; treatment; twar; vaccine; varicella; viral; virus; virus infections; virus pneumonia; viruses; white; year; young; zoster
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25. cord-009567-osstpum6
    • author: None
    • title: Abstracts Oral
    • date: 2008-04-23
    • words: 131515
    • flesch: 49
    • summary: This graft infiltration by recipient cells was more pronounced with vascularized skin grafts, and to a higher degree in heart transplants. Recipient cells similarly infiltrated allogeneic grafts early on and in larger numbers than for syngeneic grafts by day 4/5 post-transplantation.
    • keywords: + +; -/and; 24h; a20; a2all; ability; abmr; abo; absence; abstracts; accelerated; accepted; access; accumulation; accuracy; acid; activated; activation; activity; acute; acute rejection; addition; adherence; adjusted; administration; adoptive; adult; adverse; african; age; aged; agents; aih; aim; albumin; ald; alemtuzumab; alf; alive; alloag; alloantibody; alloantigen; allocation; allogeneic; allograft; allograft function; allograft recipients; allograft rejection; allograft survival; alloimmune; alloreactive; allospecific; american; amr; analysis; animals; anti; antibodies; antibody; antigen; apc; apcs; apolt; apoptosis; apoptotic; apoptotic cells; approach; artery; assay; assessment; associated; association; atg; atrophy; auc; available; average; aza; b cells; background; baff; balb; baseline; basiliximab; bcl; bead; benefit; best; better; bile; biliary; binding; biomarkers; biopsies; biopsy; bkv; blockade; blocking; blood; blood group; bm12; bmi; bone; bos; c mice; c4d; c57bl/6; c5ar; cadaveric; calcineurin; calculated; cam; cancer; candidates; capable; capacity; cardiac; cardiovascular; care; cases; caucasian; cause; cav; ccr5; ccr7; cd103; cd11c; cd138; cd154; cd20; cd25; cd28; cd3; cd4; cd4 t; cd4+cd25; cd40; cd45rb; cd62l; cd8; cd80; cd86; cdc; cell activation; cell function; cell levels; cell proliferation; cell response; cell survival; cells specific; cellular; cellular rejection; center; cfse; chains; changes; characteristics; characterized; chemokine; children; chimeras; chimeric; chimerism; chronic; chronic allograft; chronic rejection; cinacalcet; cirrhosis; cirrhotic; class; clinical; cmv; cni; cohort; cold; collected; combination; combined; common; community; comparable; comparison; complement; complete; complications; conclusion; confirm; consecutive; consistent; continued; contrast; control; control group; conventional; conversion; converted; correlate; correlation; cost; costimulatory; course; cox; cpg; creatinine; criteria; critical; cross; crossmatch; csa; ctla4; cultured; cumulative; current; cvd; cve; cyclosporine; cytokine; cytometry; cytotoxic; daclizumab; daily; damage; dap12; data; database; days; days post; dba/2; dcd; dcs; death; deceased donor; decline; decreased; deficient; degree; delayed; demographic; dendritic cells; department; dependent; depletion; deposition; dept; detectable; detection; determined; development; dgf; diabetes; diabetic; diagnosis; dialysis; differences; different; differentiation; diminished; discontinuation; disease; dln; dn t; dna; donation; donor; donor age; donor cd4; donor cells; donor kidney; donor liver; donor renal; donor specific; donor t; donor transplant; dose; dosing; double; draining; drug; dsa; duration; dysfunction; early; ebv; ecd; effect; effective; effector; effector cells; efficacy; egfr; elevated; elisa; elispot; emt; endothelial; engraftment; enhanced; episodes; epithelial cells; erk; es cells; esrd; established; evaluation; events; evidence; excellent; exchange; exosomes; expansion; expected; experience; exposure; expression; extent; facs; factors; failure; family; fashion; fasl; fcxm; features; female; fewer; fibrosis; figure; final; findings; flow; fold; follow; following; form; foxp3; foxp3 expression; free; frequency; function; functioning; future; galt; gender; gene; general; generation; genetic; genotype; gfp; gfr; gils; glomerular; glucose; goal; good; grade; graft; graft biopsies; graft failure; graft function; graft loss; graft outcome; graft rejection; graft survival; greater; group; grp; gtko; h-2; h60; half; hand; hcc; hcv; hdaf; health; heart; heart transplant; help; hepatic; hepatitis; hepatocellular; hepatocytes; heterotopic; high; higher; highest; histological; histology; history; hla; ho-1; hospital; host; hours; hpsc; hrqol; hrs; human; humoral; hypertension; hypothesis; i.v; iak; ibd; identical; ido; ieq; ifn; ifng; ifnγ; igg; iii; il-10; il-2; il-4; il-6; imaging; immune; immunity; immunohistochemistry; immunological; immunosuppression; impact; impaired; important; improved; improvement; incidence; incompatible; increase; independence; indeterminate; index; indirect; individual; induced; induction; infected; infection; infiltrates; infiltration; inflammation; inflammatory; influence; information; infusion; inhibited; inhibitor; inhibits; initial; injury; inkt; innate; institute; institution; insulin; insurance; interaction; interferon; interstitial; intestinal; intragraft; introduction; investigated; iri; isa247; ischemia; islet; islet allograft; islet transplant; isolated; ivig; january; john; kdr; key; kidney; kidney allograft; kidney cells; kidney function; kidney graft; kidney recipients; kidney transplant; kidney tx; kinase; kinetics; known; ktx; laboratory; lack; large; large t; later; ldlt; lead; left; length; lesions; leukocyte; levels; lfa-1; likely; limited; lipid; list; listing; little; liver; liver allografts; liver disease; liver graft; liver recipients; liver transplantation; living; lmp1; load; local; logistic; long; longer; loss; low; lower; lps; lsecs; lt recipients; ltx; luminex; lung; lung transplant; lymphocytes; lymphoid; m290; mab; machine; macrophage; maintenance; major; majority; male; marked; markers; marrow; marrow cells; mass; matches; maturation; mcp; mdc; mean; measured; mechanisms; median; medical; medications; medicine; meld; memory; memory t; mesangial; methods; mhc; mice; microarray; migration; mild; min/1.73; minimal; minutes; mismatched; mixed; mlr; mmf; model; moderate; modification; mofetil; molecular; molecules; monitoring; monoclonal; monocytes; mononuclear; monotherapy; months; months post; morbidity; mortality; mouse; mrna; mst; mths; multiple; multivariate; murine; mycophenolate; myd88; n=1; n=2; n=3; n=5; n=6; n=8; national; natural; naïve; necessary; necrosis; need; negative; nephropathy; network; neutrophil; new; nk cells; non; normal; novel; novo; number; objective; observed; occurring; older; olt; ongoing; onset; operational; operative; optimal; organ; organ transplant; orthotopic; outcomes; overall; ox40; p<0.001; p<0.05; paec; pairs; pancreas; panel; parameters; partial; particular; party; pathogenesis; pathology; pathway; patient survival; patients; patterns; pbmc; pcr; pd-1; pdc; peak; pediatric; peptide; percentage; performance; period; peripheral; persistent; pfd; phase; phenotype; physical; pig; pittsburgh; pkcθ; plasma; plasma cells; platelets; pod; point; policy; poor; population; porcine; positive; possible; post; post transplant; post transplantation; potential; pra; practice; predictive; predictors; prednisone; pregnancy; preliminary; presence; present; preservation; pressure; prevalence; prevention; previous; primary; priming; prior; procedure; process; production; profile; program; progressive; proliferation; prolonged; promoter; properties; proportion; prospective; protein; proteinuria; protocol; proven; ptdm; ptld; pts; purified; purpose; pvb19; qft; quality; quantitative; r348; race; randomized; range; rapa; rapamycin; rapid; rates; ratg; reaction; recent; receptor; recipient cells; recipients; recovery; recurrence; reduced; regimen; region; registry; regression; regulation; regulatory; regulatory cells; rejecting; rejection; rejection episodes; rejection patients; rejection rates; related; relationship; relative; relevant; relt; renal; renal allograft; renal function; renal transplant; renal transplantation; reperfusion; replication; reported; research; resistant; respect; response; results; retrospective; review; rise; risk; risk patients; rituximab; role; rtx; samples; sap; score; scr; screening; secondary; secretion; self; sensitivity; sensitized; sensitized patients; sequential; sera; serum; severe; severity; sex; short; shows; signaling; signals; significant; signs; similar; simultaneous; single; sinusoidal; sirna; sirolimus; site; size; skin; small; solid; solution; source; specific; specific cd8; specificity; spk; spleen; splenic; splenocytes; split; srl; stable; stable graft; stable patients; stage; staining; standard; stat1; statistical; status; stay; steroids; stimulated; stimulation; strain; strategies; strategy; stress; strong; studies; study; subjects; subsequent; subsets; successful; summary; superior; support; suppressive; surface; surgery; surgical; survey; survival; survival benefit; survival rates; survival time; sustained; syndrome; syngeneic; system; t antigen; t cells; tace; tacrolimus; target; targeting; tcmr; tcr; tcrβ; term; term graft; term survival; test; testing; tgf; tgfβ; th17; therapeutic; therapy; thrombosis; thymoglobulin; time; tissue; tissue cells; tlr4; tlr4ko; tnf; tnfα; tolerance; tolerant; tolerogenic; total; toxicity; transcription; transcripts; transduced; transferred; transgenic; transition; transplant; transplant centers; transplant model; transplant outcomes; transplant patients; transplant recipients; transplant rejection; transplant survival; transplant tolerance; transplantation; treated; treatment; treg; treg cells; trend; trial; trough; tst; tubular; tubular cells; tumor; tx patients; tx recipients; type; unclear; underwent; unique; united; univariate; university; unknown; untreated; upregulated; urinary; use; utility; vad; value; variables; vascular; vasculopathy; vegfr2; viral; virus; vitro; vivo; volume; vs.; waiting; waitlist; warm; weeks; weight; western; wild; withdrawal; women; work; worse; year; year graft; year post; yrs; zdcyd
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26. cord-010130-28bt3x25
    • author: Crocchiolo, R.
    • title: Infections after T‐replete haploidentical transplantation and high‐dose cyclophosphamide as graft‐versus‐host disease prophylaxis
    • date: 2015-03-26
    • words: 3519
    • flesch: 37
    • summary: GVHD prophylaxis was performed with Cy 50 mg/kg/day on days +3 and +4; tacrolimus 1 mg/day i.v. from day +5 (to reach a concentration of 5-15 ng/mL), or cyclosporine 3 mg/ kg/day i.v. from day +5 (to reach a concentration of 100-200 ng/mL), both up to day +100 and then tapered up to day +180, unless GVHD occurred; and mycophenolate mofetil 15 mg/kg 39 a day orally from day +5 to +35. When considering the timing of all episodes, bacterial infections occurred mostly between day 0 and +30, whereas viral infections/ reactivations between days +31 and +100, with 11.08 bacterial events/1000 pt-days between day 0 and +30, and 15.15 viral events/1000 pt-days between days +31 and +100 (Fig. 2) .
    • keywords: analysis; bacterial; blood; cell; cmv; conditioning; consecutive; cumulative; cyclophosphamide; data; day; days; disease; events; follow; fungal; gvhd; haplo; haploidentical; hematopoietic; high; hsct; i.v; ifis; incidence; infections; low; marrow; median; months; myeloablative; non; observed; patients; period; pneumonia; post; prophylaxis; rate; reactivation; related; replete; risk; stem; study; transplantation; viral; year
    • versions: original; plain text
27. cord-011030-o4jn5883
    • author: Hakki, Morgan
    • title: Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy
    • date: 2020-01-24
    • words: 7471
    • flesch: 34
    • summary: 11030 cord_uid: o4jn5883 PURPOSE OF REVIEW: CMV DNA polymerase inhibitors such as ganciclovir and foscarnet have dramatically reduced the burden of CMV infection in the HCT recipient. We review recent developments in CMV antivirals and immune-based approaches to mitigating CMV infection.
    • keywords: action; activity; adoptive; agent; allogeneic; analysis; antiviral; benefit; blind; bone; cell; cellular; clinical; cmv; cmv infection; combination; complex; cyclopropavir; cytomegalovirus; daily; development; disease; dna; donor; dose; double; drug; effects; efficacy; exposure; filociclovir; ganciclovir; gcv; hct; hct recipients; healthy; hematopoietic; high; human; immune; infection; inhibition; inhibitors; intravenous; kinase; letermovir; load; maribavir; marrow; mechanism; mutations; novel; oral; patients; pharmacokinetics; phase; placebo; polymerase; preemptive; prevention; primary; prophylaxis; randomized; recipients; refractory; renal; replication; resistance; risk; safety; seropositive; significant; similar; sot; specific; stem; studies; study; terminase; therapy; time; transplantation; treatment; trial; ul56; ul97; use; vaccine; valganciclovir; viral; viremia; vivo; weeks
    • versions: original; plain text
28. cord-011197-bmigh2rs
    • author: Yener, Nazik
    • title: Airway Pressure Release Ventilation as a Rescue Therapy in Pediatric Acute Respiratory Distress Syndrome
    • date: 2020-03-03
    • words: 3496
    • flesch: 44
    • summary: Airway pressure release ventilation in children Airway pressure release ventilation in pediatric acute respiratory distress syndrome: a randomized controlled trial High frequency oscillation and airway pressure release ventilation in pediatric respiratory failure Airway pressure release ventilation Current role of high frequency oscillatory ventilation and airway pressure release ventilation in acute lung injury and acute respiratory distress syndrome Severe hypoxemic respiratory failure: part 1: ventilatory strategies Airway pressure release ventilation: what do we know? The study included patients aged between 1 mo and 18 y, receiving APRV ventilation during index admission to the PICU and who fulfilled the diagnostic criteria of ARDS, according to the PALLIC definition and were refractory to conventional low tidal volume ventilation.
    • keywords: acute; airway; aprv; ards; authors; care; children; clinical; cmv; conventional; current; data; distress; failure; group; high; injury; intensive; low; lung; mandatory; mean; mechanical; mode; mortality; niv; oxygenation; patients; pediatric; peep; pressure; refractory; release; rescue; respiratory; sedation; severe; study; syndrome; tidal; ventilation; ventilatory; volume
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29. cord-014462-11ggaqf1
    • author: None
    • title: Abstracts of the Papers Presented in the XIX National Conference of Indian Virological Society, “Recent Trends in Viral Disease Problems and Management”, on 18–20 March, 2010, at S.V. University, Tirupati, Andhra Pradesh
    • date: 2011-04-21
    • words: 35463
    • flesch: 47
    • summary: The following virus isolates have been used in the analysis: GTPV-Uttarkashi, P60, vaccine virus; GTPV Mukteswar, P10, Challenge virus; GTPV (Akola), GTPV Bareilly/00, GTPV Ladakh/01 and GTPV Sambalpur/82, field isolates and SPPV Srinagar, P40; SPPV Ranipet, P50; SPPV-RF, P50, vaccine viruses and SPPV Makdhoom/07, SPPV CIRG/08, SPPV Pune/08, SPPV Bareilly, SPPV 183/03 and SPPV 125/02, field isolates. Present paper discusses about virus disease of quarantine importance affecting ornamental and fruit plants such as Chrysanthimum, Dahlia, Dianthus, Rosabengalensis, Cattleya, Cymbidium, Dendrobium, Lilium, Citrus, Vitis etc.
    • keywords: acid; activity; acute; addition; affected; amino; amplification; analysis; andhra; animals; antibodies; antibody; antigen; antigenic; approach; appropriate; aquaculture; areas; asia; assay; association; availability; available; begomovirus; bengal; bitter; blood; blot; bovine; breeding; brinjal; btv; buffaloes; capture; car; cases; cassava; cause; cells; cellular; chain; challenge; characterization; chikungunya; chikungunya virus; chikv; children; chilli; citrus; clinical; cloned; cloning; cmv; coat; coli; commercial; common; complete; conditions; contagious; control; conventional; core; cost; cotton; countries; country; cowpea; crop; ctv; cultivars; culture; curl; curl disease; curl virus; current; data; days; dcm; decades; delhi; delhi virus; dengue; dengue virus; department; detection; developed; development; diagnosis; different; disease; distinct; distribution; district; dna; dna vaccine; dose; drug; dsmv; earlier; early; economic; effective; efficiency; elisa; enteric; enzyme; essential; etc; experimental; expression; family; farmers; fever; field; findings; fluid; fmdv; food; foot; form; free; fruit; ganjv; gbnv; genbank; gene; general; generation; genetic; genome; genomic; genotype; genus; geographical; global; goats; groundnut; group; growth; gtpv; h1n1; hbsag; hcv; healthy; hepatitis; high; higher; highest; hiv; homology; hospital; host; hsv; human; humoral; identification; identity; igm; il-18; il-6; immune; immunity; immunization; important; incidence; india; induced; industry; infected; infection; information; inoculation; insect; isolates; isolation; jatropha; kit; laboratory; large; leaf; leaf curl; leaf samples; leaf virus; leaves; length; lesions; levels; like; limitations; limited; lineage; long; losses; lymphocytes; major; management; marker; material; maximum; measures; methods; mice; mmr; molecular; morbidity; mortality; mosaic; mosaic disease; mosaic virus; movement; multiple; nadu; natural; nature; necrosis; need; negative; new; non; ns1; nss; nucleic; nucleotide; number; order; orf; outbreaks; overall; page; palampur; papaya; paper; partial; particular; pathogens; patients; pcr; people; period; phase; phylogenetic; plant; planting; plasmid; polymerase; poor; population; positive; positivity; possible; post; potency; potential; potyvirus; pox; pradesh; presence; present; present study; prevalence; primers; probe; produce; production; products; progress; protein; protein gene; prsv; public; pune; purified; quality; quantification; quarantine; rabies; rapid; reaction; real; recent; recombinant; recombination; region; regulatory; related; relationship; replication; reported; research; resistance; response; responsible; results; rice; risk; rna; role; rotavirus; rtbv; rtsv; safety; samples; sap; scientific; screening; scylv; second; seed; selection; self; sensitive; sensitivity; sequence; sequence analysis; sequencing; sera; serological; serotypes; serum; severe; sheep; shrimp; significant; silencing; silkworm; single; size; small; south; species; specific; specific primers; specificity; specimens; sppv; spread; standard; states; sti; strains; strategies; strategy; structural; studies; study; sub; sugarcane; sunflower; symptoms; system; tamil; tcid; technology; temperature; tested; tests; time; tissue; tomato; tomato leaf; tool; total; traditional; transformation; transgenic; transmission; trials; tsv; tungro; typical; umbel; vaccinated; vaccination; vaccine; value; variability; variation; varieties; vector; vegetable; vein; vigs; viral; viral disease; virulent; virus; virus infection; virus resistance; virus specific; viruses; viz; vp1; vp2; water; weight; west; wide; world; yak; years; yellow
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30. cord-015139-s7ox0h4f
    • author: Stockschläder, M.
    • title: Atemwegsinfektionen bei immunsupprimierten Personen
    • date: 2003
    • words: 3927
    • flesch: 25
    • summary: Die Therapie der HSV-Pneumonie besteht in der Gabe von Intravenöses niedrig dosiertes liposomales Amphotericin B (2 mg/ kg KG/Tag, 3-mal/Woche) reduzierte weder die Zahl der Pilzinfektionen noch die Mortalität.
    • keywords: aids; allogen; als; alternative; amphotericin; ansprechen; antifungal; aspergillosis; aspergillus; aspergillusinfektion; auch; auf; aufgrund; bakterien; bal; behandelt; behandlung; bei; beobachtet; bereits; bis; blind; bone; bszt; candida; candidiasis; carinii; cell; chemotherapie; cmv; cytomegalovirus; dar; das; dauer; dem; der; des; deutlich; diagnosis; die; dieser; disease; dosen; dosierung; double; durch; effektivität; eine; empfohlen; entwickeln; eortc; erhalten; erkrankung; fever; fieber; fluconazol; fungal; für; gabe; ganciclovir; gerechnet; group; gvhd; haben; hiv; hochrisikopatienten; häufig; immunität; immunsuppression; immunsupprimierten; infections; infektionen; insbesondere; intravenous; intravenösem; invasive; ist; itraconazole; jedoch; kann; kg kg; kombination; können; liposomal; lunge; mal; management; marrow; mit; multicenter; muss; mycoses; nach; nachweis; neutropenic; nicht; nur; oder; oral; patienten; patients; pcr; pilzinfektionen; pneumocystis; pneumonie; prevention; prophylaxe; prospective; pulmonale; pulmonary; randomized; recipients; retinitis; selten; sich; sind; smz; sollte; stellt; stem; study; tag; tage; therapie; therapy; transplantation; transplantierten; treatment; trial; und; unter; von; vor; voriconazole; wegen; weniger; werden; wie; wird; wobei; zur
    • versions: original; plain text
31. cord-015365-iqdi99pd
    • author: None
    • title: 25th Annual Meeting of the Austrian Society of Transplantation, Transfusion and Genetics Graz, October 19–21, 2011
    • date: 2011
    • words: 30745
    • flesch: 44
    • summary: Die Reduktion der Sporenlast in der Umgebung von Ziel dieser Studie war es, die Rate von okkulten Karzinomen in unserem Kollektiv an äthyltoxischer Zirrhose erkrankter und für diese Indikation transplantierter Patienten der letzten 10 Jahre zu erheben und den Einfluss auf das rezidivfreie uund Gesamtüberleben nach Lebertransplantation zu untersuchen. Methodik.
    • keywords: -methoxy; /kg; 1st; aber; abo; activation; activity; acute; acute rejection; additional; adhesion; advagraf; age; agent; aim; albumin; alemtuzumab; allem; allogeneic; allograft; als; alternative; ami; aml; amphotericin; analyse; analysis; anderen; angiogenesis; angiotensin; animals; anti; antibodies; antibody; anticoagulation; antigen; anzahl; apoptosis; aposec; application; approach; area; arf; aspergillus; assoziiert; atg; auch; auf; aus; average; background; balb; bei; bei der; belatacept; betrug; better; bilateral; biopsies; biopsy; biounit; bis; bleeding; blockade; blood; bmt; bone; bos; brain; bypass; bzw; c4d; candida; capacity; cardiac; cardiac transplantation; care; cases; cause; cd25; cd34þ; cd4; cd8; cell transplantation; cells; cellular; center; central; changes; chemokines; children; chimeras; chimerism; chronic; clinical; cmv; cohort; combination; common; comparable; complement; complete; complications; component; composite; conclusions; conditioning; consecutive; control; costimulation; counts; course; cpb; creatinine; criteria; csa; current; cycles; cyclosporine; cyp3a5; cytokines; cytometry; damage; das; dass; data; days; daytime; dead; death; deletion; dem; der; des; development; diabetes; diagnosis; die; dieser; different; differentiation; disease; donation; donor; dosage; dose; drug; dsa; durch; durchgeführt; early; ecfcs; ecp; effect; effective; efficacy; eine; elevated; empfänger; endothelial; endotoxin; engraftment; ergebnisse; erhielten; essential; events; evidence; experimental; expression; factors; failure; female; fibrosis; findings; flow; follow; formation; foxp3; function; für; genotype; gfr; glucose; grade; graft; graz; group; grundlagen; gvhd; hand; haploidentical; hct; heart; hematopoietic; high; higher; histological; hla; ho-1; host; hsct; human; humoral; hyperplasia; i.s; igg; il-2; il-6; immune; immunosuppression; impact; impaired; implantation; important; improved; incidence; increased; induction; infection; infektionen; infiltration; inflammatory; influence; inhibitors; injury; insulin; intensity; intensive; intestinal; invasive; inzidenz; iri; irradiation; ischemia; isolated; ist; jahre; jedoch; kann; key; kidney; kidney transplantation; kir; klinische; komplikationen; konnte; können; lack; lcn-2; lebensqualität; lebertoxizität; leoligin; letzten; levels; like; limited; liver; long; loss; lower; lung; lymphocyte; lymphoid; macrophages; maintenance; major; male; malignancies; marrow; matched; mds; mean; mechanisms; median; membrane; memory; mesenchymal; methodik; methods; mhag; mice; mild; min/1.73; mismatch; mit; mit der; mittels; mixed; mmf; mobilization; model; mofetil; mononuclear; months; mortalität; mouse; msc; mspcs; mtor; multi; murine; mycophenolate; mycosis; myeloablative; myocardial; n ¼; n.s; nach; naïve; neben; necessary; need; new; nicht; nierentransplantation; nighttime; noch; non; normal; novel; novo; nude; number; nutrazeutika; oder; ogtt; ohne; old; ongoing; onset; option; organ; organ transplantation; outcome; overall; oxygen; p ¼; p38; pancreas; patienten; patienten mit; patients; pcr; percutaneous; period; peripheral; pharmacokinetics; phase; phl; pilzinfektionen; pioglitazone; platelet; plerixafor; pnad; point; poor; positive; possible; post; postoperative; potential; presence; present; previous; primary; prior; problem; procedures; production; progenitor; progression; proliferation; protective; protein; proteinurie; ptld; pulmonary; rahmen; randomized; range; rapamycin; rate; rats; receptor; recipients; recovery; reduced; reduktion; regeneration; regimen; regulatory; rejection; relapse; related; renal; reoperierten; repair; reperfusion; report; respiratory; response; results; retrospective; right; risk; role; routine; saa; safety; schlussfolgerungen; schweren; scid; sct; secretion; sein; selected; sepsis; serum; setting; severe; sich; signaling; significantly; signifikant; similar; sind; single; skin; small; solid; sowie; specific; spender; srl; stable; staining; stammzelltransplantation; standard; status; stem; stem cell; steroids; strategies; strategy; studies; study; subsequent; substanzen; successful; support; surgery; surgical; survival; syndrome; system; szt; t cells; tabic; tacrolimus; tag; tage; target; technique; term; test; therapeutic; therapie; therapy; time; tissue; tolerance; total; transient; transplant patients; transplant recipients; transplantation; transplantation background; transplanted; treatment; trial; type; und; und der; underwent; unrelated; unter; use; varizen; vascular; vasculogenesis; vasculopathy; vein; venous; vergleich; vessels; viral; viren; virus; vitro; vivo; von; vor; vur; waiting; war; waren; weeks; werden; wie; wien; wird; wound; wurde; während; years; young; zeigten; ziel; zur; zwischen; über
    • versions: original; plain text
32. cord-015389-vwgai4k9
    • author: None
    • title: Publication only
    • date: 2009-03-25
    • words: 23906
    • flesch: 53
    • summary: Two years overall survival and disease free survival of AML patients were 70% and 67% respectively. The use of this AMD3100 in combination with G-CSF in patients unable to collect adequate CD34+ cells with G-CSF alone was recently reported in 280 patients with lymphoma and multiple myeloma (MM) .
    • keywords: acid; acute; acute gvhd; adequate; adult; advanced; age; alive; allogeneic; allogeneic stem; amd3100; aml; analysis; anemia; anti; aphaeresis; aplastic; asct; atg; atll; autologous; background; bacteria; beam; blood; blood stem; bone; busulfan; cacy; cases; cd34; cell; cell transplantation; center; central; centre; chemotherapy; children; chimerism; chronic; clinical; cml; cmv; collected; combination; complete; complicated; complications; conclusion; conditioning; confi; control; cord; count; course; cryopreservation; csf; cycles; cyclophosphamide; cystatin; dasatinib; data; days; death; defi; dfs; diagnosis; different; disease; dlbcl; dli; donor; dose; early; effect; effective; effi; engraftment; eshap; expansion; experience; factors; failure; female; fever; fludarabine; follow; free; frequent; fungal; grade; graft; gram; group; gvhd; haploidentical; hematologic; hematopoietic; hematopoietic stem; high; higher; hla; hodgkin; hospital; host; hsct; identical; iii; immune; important; improvement; incidence; infection; infl; infusion; intensity; intestinal; introduction; invasive; large; later; leukemia; level; line; liver; long; lymphoma; major; malignancies; marrow; matched; mean; median; median age; median time; medium; melphalan; methods; mismatched; mixed; mobilization; mold; months; mortality; mscs; myeloablative; myeloid; n=1; n=2; negative; neutrophil; nhl; non; normal; number; old; onset; option; order; outcome; overall; partial; patients; pbsc; pcr; period; peripheral; phase; phs; platelets; poor; posaconazole; positive; post; presence; previous; primary; prior; prognosis; progression; prophylaxis; protocol; pst; pts; pulmonary; range; rate; reactivation; recipients; reconstitution; recovery; reduced; refractory; regimen; relapse; related; remission; renal; reported; research; resistant; response; results; risk; rituximab; rst; salvage; second; secondary; sepsis; serum; severe; sibling; signifi; single; skin; source; stage; standard; status; stem; stem cell; steroids; studies; study; successful; survival; symptoms; system; term; therapy; time; total; toxicity; tranexamic; transplantation; treatment; trm; type; umbilical; underwent; unit; university; unrelated; use; values; vivo; weeks; years
    • versions: original; plain text
33. cord-015922-5wwy0m2k
    • author: Marty, Francisco M.
    • title: Infection in the Hematopoietic Stem Cell Transplant Recipient
    • date: 2008
    • words: 10256
    • flesch: 30
    • summary: Hematology / the Education Program of the Invasive aspergillus infection: possible nonward common source within the hospital environment Septicemia and shock syndrome due to viridans streptococci: a case-control study of predisposing factors Introduction to marrow and blood stem cell transplantation Infectious complications associated with alemtuzumab use for lymphoproliferative disorders Infliximab use in patients with severe graftversus-host disease and other emerging risk factors of non-Candida invasive fungal infections in allogeneic hematopoietic stem cell transplant recipients: a cohort study Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning Invasive aspergillosis following hematopoietic cell transplantation: outcomes and prognostic factors associated with mortality Galactomannan and computed tomography-based preemptive antifungal therapy in neutropenic patients at high risk for invasive fungal infection: a prospective feasibility study Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia Antibacterial prophylaxis after chemotherapy for solid tumors and lymphomas Prophylactic antimicrobial agents and the importance of fitness Changing epidemiology of infections in patients with neutropenia and cancer: emphasis on gram-positive and resistant bacteria Outcomes of bacteremia in patients with cancer and neutropenia: observations from two decades of epidemiological and clinical trials Escherichia coli resistant to fluoroquinolones in patients with cancer and neutropenia Ceftazidime combined with a short or long course of amikacin for empirical therapy of gram-negative bacteremia in cancer patients with granulocytopenia. Infectious Diseases Society of America Disseminated trichosporonosis caused by Trichosporon loubieri Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia Breakthrough trichosporonosis in patients with hematologic malignancies receiving micafungin Epidemiology of Aspergillus infections in a large cohort of patients undergoing bone marrow transplantation Candidemia in allogeneic blood and marrow transplant recipients: evolution of risk factors after the adoption of prophylactic fluconazole Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus Should the consensus guidelines' specific criteria for the diagnosis of invasive fungal infection be changed? Reactivity of (1->3)-beta-d-glucan assay with commonly used intravenous antimicrobials Increasing volume and changing characteristics of invasive pulmonary aspergillosis on sequential thoracic computed tomography scans in patients with neutropenia Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia Empiric antifungal therapy in febrile granulocytopenic patients.
    • keywords: acute; acyclovir; addition; adult; agents; allogeneic; antibody; antifungal; antimicrobial; antiviral; approach; aspergillosis; aspergillus; associated; available; bacterial; benefit; blood; bone; cancer; candida; cases; cause; cell; cell transplantation; chronic; clinical; cmv; common; community; conditioning; control; cord; course; cytomegalovirus; diagnosis; disease; drug; duration; early; ebv; effective; effects; empiric; encephalitis; engraftment; experience; factors; fever; fluconazole; fungal; ganciclovir; gram; granulocytopenia; group; gvhd; hbv; hcv; hematopoietic; hepatitis; herpesvirus; high; host; hsct; hsct patients; hsv; human; immune; immunosuppression; important; incidence; infected; infection; influenza; invasive; liver; major; marrow; mold; monoclonal; mortality; negative; neutropenia; occurrence; oral; organisms; particular; pathogens; patients; pcp; percent; period; pneumonia; population; positive; post; preemptive; preengraftment; present; primary; prior; prophylactic; prophylaxis; ptld; reactivation; recipients; regimen; resistant; respiratory; response; risk; role; rsv; setting; severe; significant; specific; stem; stem cell; strategies; strategy; study; therapeutic; therapy; time; transplant; transplantation; treatment; use; vancomycin; viral; virus; viruses; voriconazole; vzv
    • versions: original; plain text
34. cord-016255-kkko1xne
    • author: van der Meer, J.T.M.
    • title: 14 Intravasale infecties en sepsis
    • date: 2011
    • words: 7440
    • flesch: 50
    • summary: Een goede indruk van de relevantie van een CMV-infectie is in die gevallen te verkrijgen door het meten van de hoeveelheid viraal DNA in bloed of plasma. Een bespreking van de aangrijpingspunten van antivirale therapie is te vinden in hoofdstuk 1 (paragraaf 1.7.2).
    • keywords: -cel; aangetoond; aantal; aantoonbaar; aanvankelijk; aanwezig; acute; afhankelijk; afrika; aids; als; andere; antigenen; antiretrovirale; antistoffen; antivirale; asymptomatische; atypische; barr; behulp; beide; belangrijkste; besproken; bij; bleek; blijkt; blijven; bloed; bloedcontact; bloedproducten; cd4; cellen; cellulaire; celmembraan; celrespons; chronische; cmv; combinaties; contact; cxcr-4; daarom; dan; dat; deel; deze; diarree; die; direct; dit; dna; door; doordat; drie; duidelijk; dus; ebv; echter; een; eerste; effectief; eiwitten; elkaar; epstein; ernstige; faryngitis; fase; figuur; gaan; gaande; gaat; gebruiken; gebruikt; geen; genoemd; genoom; gepaard; geproduceerd; gevallen; gevolg; gezien; geïnfecteerde; geïntroduceerd; goed; gp41; groot; haart; hebben; heeft; hepatitis; herstel; het; heterofiele; hiv; hiv-2; hoeveelheid; hoofdstuk; humaan; humane; humorale; hun; igm; immuniteit; immuunrespons; immuunsysteem; infectie; infectieuze; infectiosa; jaar; jirovecii; jonge; kan; kinderen; klinisch; komt; konden; koorts; korte; kunnen; laatste; lager; landen; leeftijd; leiden; leidt; load; lymfadenopathie; lymfeklier; lymfocyten; lymfocytose; maanden; maar; macrofagen; medicijnen; meer; meestal; meeste; men; micro; middel; middelen; minder; moeder; moeheid; mogelijk; mononucleosis; mutaties; naalden; naar; naast; niet; nieuwe; nog; nrti; nucleoside; onder; onderzoek; ongeveer; ontstaan; ook; opportunistische; optreden; organismen; overdracht; patiënten; perifere; personen; plaats; plasma; pneumocystis; pneumonie; positieve; primaire; reactivatie; receptor; reverse; risico; rna; rol; ruim; seksueel; seksuele; serologisch; snel; snelle; soms; specifieke; speeksel; speelt; spelen; sprake; steeds; sterke; symptomen; tegen; test; therapie; tijdens; toe; tot; transcriptase; transmissie; treedt; tussen; twee; tweede; uit; uiteindelijk; urine; vaak; vaccin; van; van de; van het; vanuit; vanwege; varianten; verloopt; verlopende; veroorzaakt; verticale; vervolgens; vindt; virale; virus; virusreplicatie; virussen; volwassenen; vooral; voorkomen; waarbij; waardoor; waarop; waarschijnlijk; wanneer; wat; weer; weken; wel; werd; wereldwijd; westerse; worden; wordt; zal; zes; zich; ziekte; ziektebeelden; zijn; zoals; zowel; zullen
    • versions: original; plain text
35. cord-016267-idrc1sdh
    • author: Ljungman, Per
    • title: Viral Infections in Hematopoietic Stem Cell Transplant Recipients
    • date: 2009-11-27
    • words: 7098
    • flesch: 31
    • summary: Prompt versus preemptive intervention for EBV lymphoproliferative disease Successful treatment with ganciclovir of presumed Epstein-Barr meningo-encephalitis following bone marrow transplant Risk of lymphoproliferative disorders after bone marrow transplantation: a multiinstitutional study The role of HLA mismatch, splenectomy and recipient Epstein-Barr virus seronegativity as risk factors in post-transplant lymphoproliferative disorder following allogeneic hematopoietic stem cell transplantation Marked increased risk of Epstein-Barr virus-related complications with the addition of antithymocyte globulin to a nonmyeloablative conditioning prior to unrelated umbilical cord blood transplantation Evaluation of use of Epstein-Barr viral load in patients after allogeneic stem cell transplantation to diagnose and monitor posttransplant lymphoproliferative disease Epstein-Barr virus (EBV) reactivation is a frequent event after allogeneic stem cell transplantation (SCT) and quantitatively predicts EBVlymphoproliferative disease following T-cell-depleted SCT High incidence of PTLD after non-T-cell-depleted allogeneic haematopoietic stem cell transplantation as a consequence of intensive immunosuppressive treatment Preemptive diagnosis and treatment of Epstein-Barr virus-associated post transplant lymphoproliferative disorder after hematopoietic stem cell transplant: an approach in development Prevention of Epstein-Barr virus-lymphoproliferative disease by molecular monitoring and preemptive rituximab in high-risk patients after allogeneic stem cell transplantation Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation Epstein-Barr virus (EBV) load in bone marrow transplant recipients at risk to develop posttransplant lymphoproliferative disease: prophylactic infusion of EBV-specific cytotoxic T cells The use of cytotoxic t cells for the prevention and treatment of epstein-barr virus induced lymphoma in transplant recipients Humanized anti-CD20 monoclonal antibody (Rituximab) in post transplant B-lymphoproliferative disorder: a retrospective analysis on 32 patients CD20 monoclonal antibody (rituximab) for therapy of Epstein-Barr virus lymphoma after hemopoietic stem-cell transplantation Epstein-Barr viral load in whole blood of adults with posttransplant lymphoproliferative disorder after solid organ transplantation does not correlate with clinical course Efficacy and safety of rituximab in B-cell post-transplantation lymphoproliferative disorders: results of a prospective multicenter phase 2 study Allogeneic cytotoxic T-cell therapy for EBV-positive posttransplantation lymphoproliferative disease: results of a phase 2 multicenter clinical trial Infusions of donor leukocytes to treat Epstein-Barr virus-associated lymphoproliferative disorders after allogeneic bone marrow transplantation Human herpesvirus 6 infections after bone marrow transplantation: clinical and virologic manifestations High levels of human herpesvirus 6 DNA in peripheral blood leucocytes are correlated to platelet engraftment and disease in allogeneic stem cell transplant patients Clinical outcomes of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation The prevalence of chromosomally integrated human herpesvirus 6 genomes in the blood of UK blood donors Transmission of integrated human herpesvirus 6 through stem cell transplantation: implications for laboratory diagnosis Human herpesvirus 6 DNA in cerebrospinal fluid specimens from allogeneic bone marrow transplant patients: does it have clinical significance? A virus infections among hospitalized adult bone marrow transplant recipients Influenza infections after hematopoietic stem cell transplantation: risk factors, mortality, and the effect of antiviral therapy Immunization of transplant recipients Antibody response to a two-dose regimen of influenza vaccine in allogeneic T cell-depleted and autologous BMT recipients Granulocyte-macrophage colony-stimulating factor as immunomodulating factor together with influenza vaccination in stem cell transplant patients The benefit of influenza vaccination after bone marrow transplantation Use of Oseltamivir to control influenza complications after bone marrow transplantation Brief communication: fatal human metapneumovirus infection in stem-cell transplant recipients Increasing incidence of adenovirus disease in bone marrow transplant recipients Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation Adenovirus infections in hematopoietic stem cell transplant recipients Adenovirus infections in adult recipients of blood and marrow transplants Outcome and clinical course of 100 patients with adenovirus infection following bone marrow transplantation Adenovirus infection after pediatric bone marrow transplantation Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery Adenoviral infection after allogeneic stem cell transplantation (SCT): report on 130 patients from a single SCT unit involved in a prospective multi center surveillance study Adenovirus infections in patients undergoing bone-marrow transplantation Assessment of disseminated adenovirus infections using quantitative plasma PCR in adult allogeneic stem cell transplant recipients receiving reduced intensity or myeloablative conditioning Fulminant adenovirus hepatitis following unrelated bone marrow transplantation: failure of intravenous ribavirin therapy Successful ribavirin therapy for severe adenovirus hemorrhagic cystitis after allogeneic marrow transplant from close HLA donors rather than distant donors Failure of intravenous ribavirin in the treatment of invasive adenovirus infection following allogeneic bone marrow transplantation: a case report Intravenous ribavirin therapy for adenovirus cystitis after allogeneic bone marrow transplantation Severe adenoviral nephritis following bone marrow transplantation: successful treatment with intravenous ribavirin Failure of ribavirin to clear adenovirus infections in T cell-depleted allogeneic bone marrow transplantation Intravenous ribavirin therapy for adenovirus gastroenteritis after bone marrow transplantation In vitro susceptibility of adenovirus to antiviral drugs is speciesdependent Early diagnosis of adenovirus infection and treatment with cidofovir after bone marrow transplantation in children Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation Cidofovir for the treatment of adenoviral infection in pediatric hematopoietic stem cell transplant patients Treatment of adenovirus disease in stem cell transplant recipients with cidofovir Monitoring of adenovirus infection in pediatric transplant recipients by quantitative PCR: report of six cases and review of the literature
    • keywords: acyclovir; adenovirus; allogeneic; antiviral; associated; barr; blood; bone; case; cell; children; cidofovir; clinical; cmv; complications; control; cystitis; cytotoxic; diagnosis; disease; dna; donor; early; ebv; encephalitis; epstein; factors; fatal; ganciclovir; globulin; gvhd; hbv; hematopoietic; hemorrhagic; hepatitis; herpesvirus; high; human; immune; immunocompromised; important; infections; influenza; load; long; lymphocyte; lymphoproliferative; marrow; measles; monitoring; mortality; patients; pneumonia; positive; preemptive; prophylaxis; prospective; ptld; reactivation; recipients; respiratory; ribavirin; risk; rsv; sct; seronegative; seropositive; severe; specific; stem; stem cell; studies; study; successful; term; therapy; transplantation; treatment; unrelated; use; varicella; viral; virus; viruses; zoster
    • versions: original; plain text
36. cord-016478-gpl0zbvd
    • author: Barry, Maura
    • title: Cytopenias in Transplant Patients
    • date: 2018-12-08
    • words: 5640
    • flesch: 26
    • summary: Solid organ transplant recipients are at risk for developing infections due to their medically induced immunodeficiency following transplant, required to prevent rejection of the transplanted organ. Solid organ transplant recipients are at risk for developing infections due to their immunosuppression, and viral infections in particular are a potential contributor to the development of thrombocytopenia following solid organ transplant.
    • keywords: abo; acute; anemia; antibodies; associated; blood; bone; calcineurin; cases; cause; cell; chronic; clinical; cmv; cytomegalovirus; cytopenias; development; disease; donor; drug; etiologies; etiology; graft; hemolytic; hemophagocytic; heparin; hepatitis; hit; immune; infection; inhibitors; itp; kidney; leukopenia; linezolid; literature; liver; low; lung; lymphocyte; management; marrow; microangiopathy; mofetil; mycophenolate; myelosuppression; organ; pancytopenia; patients; platelet; posttransplant; production; ptld; purpura; recipients; red; rejection; renal; result; review; risk; solid; solid organ; studies; study; symptoms; syndrome; tacrolimus; thrombocytopenia; thrombotic; tma; transplant; transplant recipients; transplantation; treatment; virus
    • versions: original; plain text
37. cord-016903-z2vqfq98
    • author: Herndler-Brandstetter, Dietmar
    • title: The Efficacy of Vaccines to Prevent Infectious Diseases in the Elderly
    • date: 2007
    • words: 6554
    • flesch: 27
    • summary: An evolutionary perspective on immunosenescence Lack of antibody produ ction following immunization in old age: association with CD8 +CD28' T-cell clonal expansions and an imbalance in the production of Thl and Th2 cyrokines Restoration of viral immunity in immunodeficient humans by the adoptive transfer ofT-cell clones The epidemiology of pertussis: a comparison of the epidemiology of the disease pertussis with the epidemiology of Bordetella pertussis infection An epidemic of pertussis among elderly people in a religious institution in The Netherlands Vaccination against tetanus in the elderly: do recommended vaccination strategies give sufficient protection No immunity for the elderly A population-based serologic survey of immunity to tetanus in the United States T-cells from elderly persons respond to neoantigenic stimulation with an unimpaired IL-2 production and an enhanced differentiation into effector cells Epidemiology and ecology of TBE relevant to the production of effectivevaccines TBE vaccination and the Austrian experience Vaccine Immunogenicity and safety of a booster vaccination against tick-borne encephalitis more than 3 years following the last immunisation Epidemiology and prevention of hepatitis A in travelers Hepatitis A and hepatitis B: risks compared with other vaccine preventable diseases and immunization recommendations A prospective,randomized, comparative US trial of a combination hepatitis A and B vaccine (Twinrix) with corresponding monovalent vaccines (Havrix and Engerix-B) in adults Immunogenicity of an inactivated hepatitis A vaccine in Dutch United Nations troops Immunogenicity of combined hepatitis A and B vaccine in elderly persons They display a high immunogenicity and a similar safety profile in elderly persons compared with inactivated influenza vaccines.
    • keywords: adjuvants; adults; age; aged; aging; antibody; attenuated; available; booster; cases; cd8; cell; changes; children; chronic; clinical; cmv; countries; coverage; deaths; decreased; development; different; diphtheria; diseases; effective; effector; efficacy; elderly; elderly persons; enhanced; environmental; epidemiology; european; fever; hay; health; hepatitis; herpes; high; human; immune; immunity; immunization; immunogenicity; immunosenescence; important; incidence; increase; individuals; infected; infectious; infectious diseases; influenza; instance; intervals; life; live; long; memory; morbidity; mortality; new; ofage; ofthe; old; people; persons; pertussis; pneumococcal; pneumonia; population; potent; presentation; profile; protection; reactivation; repertoire; reported; response; risk; role; safety; specific; states; strains; strategies; subunit; system; table; tbe; tetanus; trials; tuberculosis; united; vaccination; vaccine; varicella; viral; virus; viruses; vzv; years; zoster
    • versions: original; plain text
38. cord-016932-bej10xbf
    • author: Lum, Lawrence G.
    • title: Specific Adoptive T-Cell Therapy for Viral and Fungal Infections
    • date: 2018-06-19
    • words: 8107
    • flesch: 32
    • summary: Four major approaches were used: (1) stimulation with viral antigen(s) during ex vivo culture of donor T cells from peripheral blood mononuclear cells (PBMC), (2) direct selection of donor cells, (3) genetic modification of T cells to confer specific recognition of pathogen or pathogen-infected cells, or (4) arming of ex vivo expanded T cells with bispecific antibody to target the viral antigen ( Fig. 20.1 ). The Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation CD20 monoclonal antibody (rituximab) for therapy of Epstein-Barr virus lymphoma after hemopoietic stem-cell transplantation The history of vaccination against cytomegalovirus Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy Clinical aspects of CMV infection after stem cell transplantation Cytomegalovirus and varicellazoster virus vaccines in hematopoietic stem cell transplantation Infusions of donor leukocytes to treat Epstein-Barr virus-associated lymphoproliferative disorders after allogeneic bone marrow transplantation The use of anti-CD3 and anti-CD28 monoclonal antibodies to clone and expand human antigen-specific T cells Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones CMV pp65 and IE-1 T cell epitopes recognized by healthy subjects Identification of hexon-specific CD4 and CD8 T-cell epitopes for vaccine and immunotherapy T-cell therapy in the treatment of post-transplant lymphoproliferative disease Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation Large-scale expansion of dendritic cell-primed polyclonal human cytotoxic T-lymphocyte lines using lymphoblastoid cell lines for adoptive immunotherapy Analysis of CD8 T cell reactivity to cytomegalovirus using protein-spanning pools of overlapping pentadecapeptides Expansion of T cells targeting multiple antigens of cytomegalovirus, Epstein-Barr virus and adenovirus to provide broad antiviral specificity after stem cell transplantation Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor A phase I-II trial to examine the toxicity of CMV-and EBV-specific cytotoxic T lymphocytes when used for prophylaxis against EBV and CMV disease in recipients of CD34-selected/T cell-depleted stem cell transplants Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients Administration of neomycin-resistance-genemarked EBV-specific cytotoxic T lymphocytes to recipients of mismatched-related or phenotypically similar unrelated donor marrow grafts Immunotherapy targeting EBV-expressing lymphoproliferative diseases Autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for the treatment of persistent active EBV infection Adoptive immunotherapy for posttransplantation viral infections Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virusspecific T-cell lines Generation of CMV-specific T lymphocytes using protein-spanning pools of pp65-derived overlapping pentadecapeptides for adoptive immunotherapy Rapidly generated multivirus-specific cytotoxic T lymphocytes for the prophylaxis and treatment of viral infections Naïve T-cell-derived CTL recognize atypical epitopes of CMVpp65 with higher avidity than CMVseropositive donor-derived CTL -a basis for treatment of post-transplant viral infection by adoptive transfer of T-cells from virus-naïve donors Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets The role of virus-specific adoptive T-cell therapy in hematopoietic transplantation Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus Reversible HLA multimers (Streptamers) for the isolation of human cytotoxic T lymphocytes functionally active against tumor-and virus-derived antigens Adoptive transfer and selective reconstitution of streptamerselected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation Immunobiology : the immune system in health and disease Adoptive cellular therapy: a race to the finish line The promise and potential pitfalls of chimeric antigen receptors Tumor-specific T-bodies: towards clinical application CMV-specific TCR-transgenic T cells for immunotherapy Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity Development of genetically engineered CD4+ and CD8+ T cells expressing TCRs specific for a M. tuberculosis 38-kDa antigen Engineering T cells specific for a dominant severe acute respiratory syndrome coronavirus CD8 T cell epitope Antigen-specific CD8+ T cells respond to Chlamydia trachomatis in the genital mucosa Reconstitution of anti-HIV effector functions of primary human CD8 T lymphocytes by transfer of HIV-specific alphabeta TCR genes T-cell engineering by a chimeric T-cell receptor with antibody-type specificity for the HIV-1 gp120 Anti-HIV designer T cells progressively eradicate a latently infected cell line by sequentially inducing HIV reactivation then killing the newly gp120-positive cells Characterization of T cell-expressed chimeric receptors with antibodytype specificity for the CD4 binding site of HIV-1 gp120 Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLApeptide tetramers Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation Directly selected cytomegalovirus-reactive donor T cells confer rapid and safe systemic reconstitution of virus-specific immunity following stem cell transplantation Reconstitution of EBV-specific T cell immunity in solid organ transplant recipients Complete regression of posttransplant lymphoproliferative disease using partially HLA-matched Epstein Barr virus-specific cytotoxic T cells Treatment of Epstein-Barr-virus-positive post-transplantation lymphoproliferative disease with partly HLAmatched allogeneic cytotoxic T cells Allogeneic cytotoxic T-cell therapy for EBV-positive posttransplantation lymphoproliferative disease: results of a phase 2 multicenter clinical trial A novel haploidentical adoptive CTL therapy as a treatment for EBV-associated lymphoma after stem cell transplantation Effective and long-term control of EBV PTLD after transfer of peptide-selected T cells Successful treatment of EBV-associated posttransplantation lymphoma after cord blood transplantation using third-party EBV-specific cytotoxic T lymphocytes Successful treatment of a classic Hodgkin lymphoma-type posttransplant lymphoproliferative disorder with tailored chemotherapy and Epstein-Barr virus-specific cytotoxic T lymphocytes in a pediatric heart transplant recipient Thirdparty virus-specific T cells eradicate adenoviraemia but trigger bystander graft-versus-host disease Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV Polyomavirus JC-targeted T-cell therapy for progressive multiple leukoencephalopathy in a hematopoietic cell transplantation recipient Rapid salvage treatment with virus-specific T cells for therapyresistant disease Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation Monoculturederived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals Prophylactic infusion of cytomegalovirusspecific cytotoxic T lymphocytes stimulated with Ad5f35pp65 gene-modified dendritic cells after allogeneic hemopoietic stem cell transplantation Multicenter study of banked third-party virusspecific T cells to treat severe viral infections after hematopoietic stem cell transplantation Safety and clinical efficacy of rapidly-generated trivirus-directed T cells as treatment for adenovirus, EBV, and CMV infections after allogeneic hematopoietic stem cell transplant Donor-derived CMV-specific T cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation Activity of broad-spectrum T cells as treatment for AdV, EBV, CMV, BKV, and HHV6 infections after HSCT Targeted T-cell therapy in stage IV breast cancer: a phase I clinical trial Phase I study of anti-CD3 x anti-Her2 bispecific antibody in metastatic castrate resistance prostate cancer patients Anti-CD3 x anti-EGFR bispecific antibody redirects T cell cytolytic activity to EGFR-positive cancers in vitro and in an animal model T cells armed with anti-CD3 x anti-CD20 bispecific antibody enhance killing of CD20+ malignant B-cells and bypass complement-mediated Rituximab-resistance in vitro CD20-targeted T cells after stem cell transplantation for high risk and refractory non-Hodgkin's lymphoma Multiple infusions of CD20-targeted T cells and low-dose IL-2 after SCT for high-risk non-Hodgkin's lymphoma: a pilot study Targeting cytomegalovirus-infected cells using T cells armed with anti-CD3× anti-CMV bispecific antibody Accelerated production of antigen-specific T cells for preclinical and clinical applications using gas-permeable rapid expansion cultureware (G-Rex) T-cell therapies for HIV Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes for adoptive immunotherapy of HPV-associated malignancies Adverse events following infusion of T cells for adoptive immunotherapy: a 10-year experience Human MHC class I-restricted high avidity CD4 T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo Cord blood T cells retain early differentiation phenotype suitable for immunotherapy after TCR gene transfer to confer EBV specificity Beta-glucan recognition by the innate immune system Immunity to fungal infections Current challenges in the diagnosis and management of invasive fungal infections: report from the 15th international symposium on infections in the immunocompromised host Generation of highly purified and functionally active human TH1 cells against Aspergillus fumigatus Generation of a multipathogen-specific T-cell product for adoptive immunotherapy based on activation-dependent expression of CD154 Clinicalscale generation of multi-specific anti-fungal T cells targeting Candida, Aspergillus and mucormycetes Clinical-scale generation of human anti-Aspergillus T cells for adoptive immunotherapy Robust polyfunctional T-helper 1 responses to multiple fungal antigens from a cell population generated using an environmental strain of Aspergillus fumigatus Generation and characterization of anti-Candida T cells as potential immunotherapy in patients with Candida infection after allogeneic hematopoietic stem-cell transplant Cross-protective TH1 immunity against Aspergillus fumigatus and Candida albicans Characterization of the T-cell-mediated immune response against the Aspergillus fumigatus proteins Crf1 and catalase 1 in healthy individuals CD4+ and CD8+ T cells mediate adoptive immunity to aerosol infection of Mycobacterium bovis bacillus Calmette-Guerin Lowest numbers of primary CD8(+) T cells can reconstitute protective immunity upon adoptive immunotherapy Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen Biochemical and immunological characterization of MP65, a major mannoprotein antigen of the opportunistic human pathogen Candida albicans Characterization of the cellular immune responses to Rhizopus oryzae with potential impact on immunotherapeutic strategies in hematopoietic stem cell transplantation Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506) Generation of EBV-specific cytotoxic T cells that are resistant to calcineurin inhibitors for the treatment of posttransplantation lymphoproliferative disease Acknowledgments Special thanks to the clinical coordinators for dedicating their efforts to serve the immunotherapy patients.
    • keywords: activity; adenovirus; adoptive; adv; advances; allogeneic; anti; antibody; antigen; antiviral; approach; aspergillus; atc; autologous; barr; blood; cancer; candida; cd3; cd4; cd8; cells; clinical; clones; cmv; cord; ctls; culture; cytomegalovirus; cytotoxic; disease; donor; early; ebv; effective; effector; epitopes; epstein; expansion; following; fungal; generation; gvhd; hematopoietic; high; hiv; hla; hpv; hsct; human; ifn; immune; immunity; immunotherapy; infections; infusions; invasive; lymphocytes; lymphoma; lymphoproliferative; major; memory; modified; multiple; naive; party; pathogen; patients; peptide; phase; pools; post; pp65; products; ptld; rapid; receptor; recipients; reconstitution; responses; restricted; risk; selection; specific; specific ctls; specificity; stem; stem cell; stimulation; strategy; studies; t cells; target; targeted; targeting; tcr; therapy; transduced; transfer; transplantation; treatment; trials; use; vctl; viral; virus; vivo
    • versions: original; plain text
39. cord-016990-ot1wi3xi
    • author: Zaki, Sherif R.
    • title: Viral Infections of the Lung
    • date: 2008
    • words: 19595
    • flesch: 28
    • summary: Preceding respiratory infection predisposing for primary and secondary invasive Haemophilus influenzae type b disease Viral-bacterial synergistic interaction in respiratory disease Immune impairment of alveolar macrophage phagocytosis during influenza virus pneumonia Mechanisms of bacterial superinfect ions in viral pneumonias Impact of respiratory virus infections on persons with chronic underlying conditions Identification of a new North American hantavirus that causes acute pulmonary insufficiency Nipah virus: a recently emergent deadly paramyxovirus Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness Varicella-related mortality in California Decline in mortality due to varicella after implementation of varicella vaccination in the United States Pneumonia caused by herpesviruses in recipients of hematopoietic cell transplants Initial genetic characterization of the 1918 Spanish influenza virus Characterization of the reconstructed 1918 Spanish influenza pandemic virus Transmission of lymphocytic choriomeningitis virus by organ transplantation A morbillivirus that caused fatal disease in horses and humans Fatal West Nile virus encephalitis in a renal transplant recipient Transmission of West Nile virus from an organ donor to four transplant recipients Transmission of rabies virus from an organ donor to four transplant recipients Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture Recovery of new agent from patients with acute respiratory illness Adenoviruses: group name proposed for new respiratory-tract viruses Adenoviruses in the immunocompromised host Fatal disseminated adenovirus infections in immunocompromised patients Respiratory disease and the adenoviruses Adenoviruses from human immunodeficiency virus-infected individuals, including two strains that represent new candidate serotypes Ad50 and Ad51 of species Bl and D, respectively Infections in 18,000 infants and children in a controlled study of respiratory tract disease. 102 Multinucleated syncytial cells similar to those seen in some SARS patients can also be found in a number of virus infections, including measles, parainfluenza viruses, RSV, and Nipah virus infections.
    • keywords: acute; acute respiratory; adenovirus; adults; agent; airway; alveolar; antibodies; antibody; antigens; appearance; areas; assays; associated; autopsy; b19; bacterial; blood; bone; bronchiolitis; cases; cause; cell pneumonia; cells; cellular; certain; changes; characteristic; children; clinical; cmv; common; coronavirus; cough; counterstain; culture; cytomegalovirus; cytopathic; cytoplasmic; dad; damage; days; deaths; detection; diagnosis; diameter; different; difficult; diffuse; disease; dna; early; edema; electron; encephalitis; endothelial; envelope; eosinophilic; epidemic; epithelial; epithelial cells; evidence; extensive; family; fast; fatal; features; fever; fibrin; fig; findings; formalin; fusion; genome; genus; giant; giant cells; glycoproteins; group; h&e; hantavirus; hematoxylin; hemorrhagic; hendra; herpes; herpesviruses; herpetic; hfrs; histopathologic; history; hmpv; host; hpiv; hps; hsv; human; hybridization; ihc; illness; immune; immunoalkaline; immunocompromised; immunodeficiency; immunohistochemistry; important; inclusions; infants; infected; infection; infiltrates; inflammatory; influenza; influenza virus; interstitial; intranuclear; involvement; ish; isolated; isolation; laboratory; large; lesions; like; liver; lower; lower respiratory; lung; macrophages; manifestations; marrow; measles; measles infection; measles virus; membrane; metapneumovirus; microscopy; mononuclear; months; mortality; multinucleated; naphthol; necrosis; necrotic; necrotizing; negative; new; nipah; nipah virus; nucleic; nucleocapsid; occasional; onset; organ; outbreak; paddock; pandemic; parainfluenza; parainfluenza virus; particles; parvovirus; pathogenesis; pathogens; pathology; patients; pcr; persons; phosphatase; pneumocytes; pneumonia; pneumonitis; presence; primary; protein; pulmonary; rapid; rash; reaction; recipients; red; related; replication; respiratory; respiratory disease; respiratory syncytial; respiratory syndrome; respiratory tract; respiratory virus; risk; rna; rsv; s.r; samples; sars; secondary; serologic; serotypes; severe; severe acute; similar; simplex; simplex virus; single; situ; skin; small; specific; specimens; spread; stain; staining; states; studies; study; surface; symptoms; syncytial; syncytial virus; syndrome; techniques; tests; tissues; tract; tract disease; transplant; type; typical; ultrastructural; united; upper; useful; varicella; viral; viral antigens; virions; virus; virus infection; virus pneumonia; viruses; vzv; years; young; zaki; zoster; zoster virus
    • versions: original; plain text
40. cord-016998-6n662amh
    • author: None
    • title: Nierentransplantation
    • date: 2007
    • words: 6873
    • flesch: 35
    • summary: Im Schnitt lag die 1-Jahres-Transplantatüberlebensrate Ende der 1970er Jahre bei etwa 55%, in der ersten Hälfte der 1980er Jahre bei etwa 75% und in der zweiten Hälfte bei fast 90%. Die Plasmaspiegel von Phosphat, AP, β 2 -Mikroglo-bulin und Parathormon fallen, die Kalzifikationen nehmen ab.
    • keywords: 1980er; aber; absetzen; abstoßung; akute; allerdings; allograft; als; alter; anderen; antigene; antikörper; anzahl; atg; auch; auf; aufgrund; auftreten; aus; ausgeschlossen; ausmaß; auswirkung; azathioprin; basalmembran; bedeutet; behandlung; bei; bei der; beim; bereits; beschrieben; besser; besteht; beträgt; bezeichnet; bis; bisher; bluttransfusionen; bzw; chain; chronische; ciclosporin; cmv; crossmatch; dagegen; damit; dann; das; dass; dem; der; derjenigen; derzeit; des; deswegen; deutlich; diabetiker; diabetischen; dialysepatienten; diarrhö; die; diese; dosen; dosis; durch; durchgeführt; ebv; eine; eingesetzt; empfänger; entwickeln; entwicklung; erfolgreiche; ergebnisse; erkrankung; ersten; etwa; faktor; fieber; form; frühen; führen; führt; für; gabe; gancyclovir; gegen; gegenüber; gehäuft; gelegentlich; geringer; getestet; gibt; gilt; gleiches; gleichzeitig; glomerulonephritis; grunderkrankung; gut; haben; hat; hauptsächlich; hcv; hepatitis; histologische; hla; hoher; hus; hälfte; häufig; häufiger; häufigsten; höhere; ihre; il-2; immunsuppression; induktionstherapie; infektion; innerhalb; insgesamt; interferon; inzidenz; ist; jahren; jedoch; kann; kette; kidney; klasse; klinisch; kombination; kommen; kommt; konnte; können; langsam; lebendspende; leukopenie; leukozytenzahlen; liegen; liegt; lymphome; lymphoproliferativen; lymphozyten; mal; man; mehr; meist; meisten; menschen; mikroemulsion; mindestens; mismatch; mit; monaten; mortalität; muss; mycophenolat; möglich; nach; nach transplantation; nebenwirkungen; nekrose; nicht; niedrig; niereninsuffizienz; nierentransplantation; nierentransplantierten; noch; normalerweise; nur; oder; oft; ohne; okt; opportunistischen; organe; pancreas; panel; patienten; plasmaspiegel; polyomaviren; positiver; prophylaxe; proteinurie; rate; reaktivität; recipients; reduktion; reduziert; region; rejection; renal; rezidiv; rezidivrate; risiko; sehr; seit; selten; seltener; sensibilisierung; sich; sie; signifikant; sind; sog; sollte; sowie; sowohl; spender; spricht; steroiddosis; steroiden; stimulation; studien; syndrom; tacrolimus; test; transplantatfunktion; transplantathalbwertszeit; transplantation; transplantatverlust; transplantatüberleben; tripletherapie; tritt; trotz; typ; und; unter; unterscheidet; urin; vaskulärer; verabreicht; verlauf; vermeidung; vermutlich; versteht; verwandte; veränderungen; viele; virus; vom; von; von ciclosporin; vor; vorhandensein; war; waren; weitgehend; wenn; werden; wichtige; wird; wurde; während; zahl; zeichen; zell; zellen; zellulärer; zentren; zum; zur; zusammen; zwar; zwei; zwischen; zytokinen; über; übereinstimmung; überlebensrate
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41. cord-017012-yl0vanuh
    • author: Herberg, Jethro
    • title: Infectious Diseases and the Kidney
    • date: 2009
    • words: 23989
    • flesch: 30
    • summary: Bacterial infections associated with renal disease and the likely mechanisms causing renal dysfunction are shown in > Impaired renal function is a common occurrence in systemic sepsis (1) . The group A streptococci (GAS) are a major worldwide cause of renal disease, usually as poststreptococcal nephritis.
    • keywords: activation; acute; acute renal; addition; administration; adults; affected; africa; agents; allograft; antibiotic; antibodies; antibody; antigens; antiviral; apsgn; areas; associated; association; asymptomatic; bacterial; beta; biopsy; bkv; blood; capillary; cases; cause; cells; changes; childhood; children; chronic; circulation; clinical; cmv; coli; combination; common; complement; complexes; complication; congenital; countries; course; creatinine; damage; days; dengue; deposition; deposits; developed; development; diagnosis; dialysis; different; diffuse; direct; disease; disorder; distribution; dysfunction; early; effective; effects; electron; elevated; endocarditis; endothelial; epithelial; evidence; exposure; factors; falciparum; family; features; fever; findings; focal; forms; fulminant; function; gas; glomerular; glomerulonephritis; glomerulosclerosis; good; group; hbsag; hbv; hcv; hematuria; hemolytic; hemorrhagic; hepatic; hepatitis; high; histologic; hiv; hivan; human; hus; hypertension; hypovolemia; iga; igg; igm; illness; immune; immunocompromised; immunodeficiency; immunoglobulin; impairment; important; incidence; induced; infants; infected; infection; inflammatory; initial; injury; intensive; interferon; interstitial; intravenous; invasive; involvement; kidney; late; leptospirosis; lesions; levels; likely; liver; low; major; malaria; management; manifestations; mechanisms; membrane; meningococcal; mesangial; mgn; microscopy; mild; months; mortality; mountain; mpgn; necrosis; nephritis; nephropathy; nephrotic; nephrotic syndrome; normal; oliguria; onset; organisms; outcome; pathogenesis; pathophysiology; patients; pcr; pediatric; persistent; phase; plasma; pneumoniae; population; positive; prerenal; presence; present; primary; prognosis; proliferative; proportion; proteinuria; pulmonary; range; rash; recent; recipients; recovery; renal; renal biopsy; renal disease; renal failure; renal function; renal involvement; renal syndrome; renal transplant; renal transplantation; replacement; reported; reports; respiratory; response; results; review; ribavirin; risk; rocky; role; salmonella; secondary; segmental; sepsis; septic; serum; severe; severe cases; shock; shock syndrome; significant; similar; skin; specific; spread; stage; staphylococcal; states; strains; streptococcal; studies; study; support; symptoms; syndrome; systemic; therapy; thrombocytopenia; toxic; tract; transplant; transplantation; treatment; tubular; tubules; tubulointerstitial; united; urinary; urine; varicella; vasculitis; viral; virus; virus infection; viruses; volume; weeks; worldwide; years; yersinia
    • versions: original; plain text
42. cord-017030-tzuyo6tx
    • author: Henao-Martínez, Andrés F.
    • title: Infections in Heart, Lung, and Heart-Lung Transplantation
    • date: 2018-12-08
    • words: 11550
    • flesch: 29
    • summary: Although relatively rare in heart transplant recipients (frequency <1%), Nocardia is only second in frequency in heart transplant after lung transplant recipients Trypanosoma cruzi infection reactivation manifested by encephalitis in a Chagas heart transplant recipient Central nervous system infections in heart transplant recipients Listeria meningitis in transplant recipients Progressive multifocal leukoencephalopathy in transplant recipients Progressive multifocal leukoencephalopathy in a heart transplant recipient following rituximab therapy for antibody-mediated rejection Clinical spectrum of gram-positive infections in lung transplantation Frequency of Pseudomonas aeruginosa colonizations/infections in lung transplant recipients Non-tuberculous mycobacterial infection among lung transplant recipients: a 15-year cohort study Nocardia infection in lung transplant recipients Challenges in the diagnosis and management of Nocardia infections in lung transplant recipients Fungal infections after lung transplantation Significance of blood stream infection after lung transplantation: analysis in 176 consecutive patients Aspergillus infections after lung transplantation: clinical differences in type of transplant and implications for management The incidence of invasive aspergillosis among solid organ transplant recipients and implications for prophylaxis in lung transplants Risk factors and outcomes in lung transplant recipients with nodular invasive pulmonary aspergillosis Immune reconstitution syndrome-like entity in lung transplant recipients with invasive aspergillosis Anastomotic infections in lung transplant recipients Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America Cellulitis caused by Cryptococcus neoformans in a lung transplant recipient An immune reconstitution syndrome-like illness associated with Cryptococcus neoformans infection in organ transplant recipients Cytomegalovirus in transplantation -challenging the status quo Cytomegalovirus and lung transplantation A polymorphism linked to elevated levels of interferon-gamma is associated with an increased risk of cytomegalovirus disease among Caucasian lung transplant recipients at a single center Cytomegalovirus replication within the lung allograft is associated with bronchiolitis obliterans syndrome Ganciclovir-resistant cytomegalovirus (CMV) infections among lung transplant recipients are associated with poor outcomes despite treatment with foscarnet-containing regimens Community-acquired respiratory viral infections in lung transplant recipients Incidence and outcomes of respiratory viral infections in lung transplant recipients: a prospective study Viral infections in lung transplant recipients Antiviral agents for the treatment and chemoprophylaxis of influenza -recommendations of the Advisory Committee on Immunization Practices (ACIP)
    • keywords: abdominal; aeruginosa; allograft; antifungal; antimicrobial; aspergillosis; aspergillus; associated; aureus; bacteremia; bacterial; blood; bloodstream; candida; cardiac; cases; cause; cell; centers; chagas; chronic; clinical; cmv; cns; colonization; common; community; complications; cruzi; cryptococcus; cystic; cytomegalovirus; d+/r−; days; death; development; diagnosis; disease; donor; early; ebv; encephalitis; endemic; epidemiology; factors; failure; fibrosis; frequent; fungal; fungi; graft; gram; heart; heart transplant; heart transplantation; hepatitis; herpes; high; higher; history; hsv; immunosuppression; important; incidence; increase; infections; influenza; invasive; involvement; late; listeria; lung; lung recipients; lung transplant; lung transplantation; management; manifestations; median; mediastinitis; meningitis; months; morbidity; mortality; mycobacterium; negative; nocardia; nodules; non; nosocomial; ntm; organ; organ transplant; organisms; osteomyelitis; outcomes; patients; period; pneumonia; population; posttransplant; potential; presence; present; previous; primary; prophylaxis; pseudomonas; pulmonary; rare; rate; reactivation; recipients; rejection; reported; respiratory; review; risk; scedosporium; setting; significant; single; skin; solid; sot; species; spp; staphylococcus; surgery; surgical; survival; symptoms; syndrome; therapy; time; toxoplasma; toxoplasmosis; tract; transplant; transplant patients; transplant recipients; transplantation; treatment; trypanosoma; tuberculosis; type; viral; virus; viruses; vzv; year; zoster
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43. cord-017782-dtveihrj
    • author: Fong, I. W.
    • title: Litigations for HIV Related Complications
    • date: 2010-11-30
    • words: 6298
    • flesch: 48
    • summary: The GP(general practitioner) then initiated a regimen consisting of didanosine, lamivudine, and saquinavir for HIV infection. Specific charges were: (1) the GP should have repeated the HIV serology to confirm that the plaintiff was HIV infected, (2) the defendant was negligent in starting treatment for HIV infection without proof of disease, (3) the physician lacked knowledge of HIV infection and should have referred the patient to a specialist or HIV clinic, (4) treatment of toxic medications were given for several years without any clear indication, and (5) the GP did not adequately inform the patient on the pros and cons of therapy, nor explain the potential toxicities and side-effects.
    • keywords: aids; appointment; art; asymptomatic; blood; cd4; cell count; cells; clinical; cmv; complications; conditions; copies; count; course; defendant; disease; earlier; elisa; evidence; examination; eye; failure; false; haart; history; hiv; hiv infection; hiv-1; hospital; human; illness; immune; immunodeficiency; infected; infection; later; levels; life; long; loss; low; lymphocytes; medical; months; patients; peripheral; phone; physician; plaintiff; plasma; positive; progression; rapid; results; retinitis; risk; rna; seroconversion; serology; specialist; status; subjects; symptoms; test; testing; therapy; time; treatment; viral; virus; vision; visual; weeks; years; zone
    • versions: original; plain text
44. cord-018331-ovmtz4sb
    • author: Dancygier, Henryk
    • title: Viral Infections by Nonhepatotropic Viruses
    • date: 2010
    • words: 2986
    • flesch: 33
    • summary: CMV hepatitis in the immunocompetent host clinically resembles hepatitis of infectious mononucleosis [14] . The course of CMV hepatitis is self-limited, and chronic hepatitis does not ensue.
    • keywords: acute; adults; aminotransferases; ammatory; appearance; cases; cause; cells; clinical; cmv; dengue; disease; ebv; failure; fever; focal; fulminant; giant; hemorrhagic; hepatic; hepatitis; hepatocellular; hepatocytes; herpes; histological; hsv; human; inclusions; infection; infi; infl; injury; involvement; liver; mild; mononucleosis; necrosis; organ; parenchymal; parvovirus; patients; portal; primary; rare; rate; report; severe; simplex; steatosis; syndrome; transplantation; varicella; viral; virus; viruses
    • versions: original; plain text
45. cord-018393-5jlqn7wq
    • author: Finke, Ernst-Jürgen
    • title: Bioterrorismus, infektiologische Aspekte
    • date: 2011-12-14
    • words: 25034
    • flesch: 39
    • summary: Die CMV-Primärinfektion verläuft in der Mehrzahl der Fälle asymptomatisch. im Gegensatz zur Lymphatischen Filariose durch Wuchereria bancrofti (7 Wuchereria) nicht in der Genitalregion, entsprechend beschränken sich Lymphadenitis und Lymphangitis auf die Region der Extremitäten (gelegentlich sind die Mammae betroffen).
    • keywords: aber; aber auch; abgeschlagenheit; abhängigkeit; abortus; abs; abstrich; abszesse; abzugrenzen; adulten; aedes; affen; agar; agenzien; aids; aktive; akuten; alle; allein; allerdings; allgemeinen; als; als auch; alter; amöben; amöbiasis; anaeroben; andere; anfangs; angeboten; anschlag; anschläge; antibiotika; antibiotische; antigene; antikörper; antikörper gegen; antivirale; anzusehen; anämie; arten; arthropoden; asymptomatisch; atypische; auch; auch bei; auch der; auch die; auch durch; auf; auf das; auf der; auf eine; aufgeklärt; aufgenommen; aufgrund; aufl; aufnahme; auftreten; auge; aus; aus dem; ausbreitung; ausbrüche; ausgebracht; ausgelöst; ausschließlich; ausschluss; außerdem; bakteriellen; bakterien; barr; bauchschmerzen; bdv; bedeutung; bedingungen; befall; befinden; befunde; beginn; behandlung; bei; bei anderen; bei der; bei einer; bei infektionen; bei kindern; beim; bekannt; bekämpfung; bekämpfung der; beobachtet; bereich; bereits; beruht; beschrieben; besiedelten; besitzen; besonders; bestandteil; besteht; besteht keine; besteht nicht; bestimmte; betracht; betroffen; beträgt; bettwanzen; bevölkerung; beweglich; beweglichkeit; bezeichnet; bilden; bildung; biologische; bis; bis zu; bisher; bleiben; bleibende; blut; blutbahn; blutkultur; blutzellen; bzw; c ist; cardiobacterium; cd4; cd8; cephalosporine; chemoprophylaxe; chikungunya; chlamydien; chloramphenicol; chronisch; citrobacter; clindamycin; clinical; cmv; coli; corrodens; coxsackieviren; cyclospora; dabei; dadurch; daher; damit; danach; dann; dar; darauf; darm; darüber; das; das virus; dass; dass die; daten; davon; dekontamination; dem; den menschen; denen; dengueviren; denv; der; der als; der cmv; der erkrankung; der erreger; der h.-pylori; der haut; der hepatitis; der herzklappen; der infektion; der mensch; der nachweis; der nicht; der regel; des; deutlich; deutschland; dhf; diagnose; diagnostik; diarrhoe; die; die als; die nicht; diese; differenzialdiagnostisch; difficile; direkt; direkten; disease; diskutiert; dna; drei; dss; durch; durch andere; durch antikörper; durch das; durch den; durch die; durch eine; durchfälle; durchgeführt; early; ebenfalls; ebenso; ebolavirus; ebv; echoviren; edn; eier; eignen; eindringen; eine; eine infektion; eingesetzt; einhaltung; einige; einsatz; einschließlich; einstichstelle; einzelfällen; einzelnen; ektoparasiten; elisa; empfindlich; empfohlen; endemiegebieten; endogene; endokarditis; entamoeba; entdeckung; enteroviren; enthalten; enthält; entscheidende; entsprechend; entstehen; entsteht; entweder; entwickeln; entwicklung; entzündung; enzephalitis; epidemien; epstein; erbrechen; ereignissen; erfolgen; erfolgt; erforderlich; erheblich; erhältlich; erhöhtes; erkannt; erkennen; erkennung; erkrankten; erkrankung; erlauben; erreger; erregernachweis; erst; ersten; erwachsenen; es bei; es besteht; es ist; es nicht; es sind; es zu; escherichia; etwa; europa; europäischen; existieren; expertenlaboratorien; exponierten; exposition; expositionsprophylaxe; extrem; fakultativ; familie; fehlen; fernöstlichen; fieber; fieber und; finden; flaviviren; form; frage; frauen; frühzeitig; fsme; fungieren; fäkal; fälle; färbung; führen; führt; für; für das; für den; für die; für eine; gabe; gastritis; gastroenteritis; gbv; gebildet; geeignete; gefahr; gefunden; gegeben; gegen; gegen das; gegen die; gegensatz; gegenwärtig; gegenüber; gehirn; gehören; gekennzeichnet; gelbfiebervirus; gelegentlich; gemäß; genannten; genbank; genese; genom; genus; gestellt; gewebe; gezielte; ggf; gibt; gibt es; gilt; gleichzeitig; gramnegative; grippeähnliche; große; grundsätzlich; größer; gute; h.-pylori; haben; handelt; hantavirus; harnwegsinfektionen; hat; hauptsächlich; haut; hav; hbsag; hbv; hcv; hepatitiden; hepatitis; hepatosplenomegalie; herpes; herzklappen; heute; hev; hier; hierbei; hin; hinaus; hinweise; hinzu; histolytica; hiv; hoch; hohe; hominis; hrsg; hsv; humanen; humorale; husten; hygiene; hygienischen; häufig; häufiger; häufigsten; höher; identifizierung; ifn; ifsg; igg; igm; ihnen; ihre; ikterus; immer; immunantwort; immundefizienz; immunisierung; immunität; immunkompetenten; immunsupprimierte; immunsystem; impfstoffe; impfung; impfungen; infectious; infektiologie; infektion; infektion mit; infektion werden; infektionen durch; infektionen sind; infektionserreger; infektionskrankheiten; infektionsschutzgesetz; infektiöse; infizierten; initial; inkubationszeit; innerhalb; innerhalb von; insbesondere; insbesondere bei; insektiziden; institutionen; interferon; interstitielle; invasive; isoliert; ist; ist bei; ist das; ist der; ist die; ist durch; ist eine; ist mit; ist nicht; ist von; ist zu; jahre; jedem; jedoch; jeweiligen; juckreiz; kann; kann bei; kann der; kann die; kann eine; kann es; kann sich; kaum; kausale; keine daten; keine meldepflicht; keinen; kindern; kleidung; kleine; klinischen; koch; kolonien; kommen; kommt; kommt es; konjunktivitis; konnte; kontakt; kontaktpersonen; kontrolle; kopfschmerzen; korreliert; krankheit; krankheitsbild; krankheitserregern; krankheitsphase; krankheitsverdächtigen; krankheitsverlauf; kulturelle; können; können auch; labor; lang; larven; lassen; leber; leicht; letalität; letzten; liegen; liegt; linie; liquor; lokale; lokalisation; lunge; lymphadenitis; lymphadenopathie; lymphknoten; lymphozyten; ländern; länger; lässt; läuse; makrophagen; man; management; maßnahmen; medikamente; medizinische; mehr; mehrere; meist; meisten; melden; meldepflicht; menge; meningitis; menschen; menschlichen; metronidazol; mikrobiologie; mikrobiologischen; mikroskopie; mikroskopische; milben; mindestens; mit; mit anderen; mit c.; mit der; mit einer; mit fieber; mithilfe; mittels; monate; monozyten; moskito; multiresistenz; muskelschmerzen; muss; möglich; möglicherweise; möglichst; müssen; nach; nach der; nach einer; nach infektion; nachgewiesen; nachgewiesen werden; nachweis; nachweis aus; nachweis von; nachweisbar; nachweisverfahren; namentlich; nationale; natürliche; neben; new; nicht; nicht auf; nicht bekannt; nicht durch; nicht oder; nicht von; niedrigem; noch; noch nicht; normalen; normalflora; notwendig; nur; nur bei; oberen; oder; oder der; oder durch; oder ein; oder mit; offenbar; oft; ohne; oozysten; oral; oraler; organe; ornithose; osteomyelitis; parasitologischen; parodontitis; pathogene; pathogenität; pathophysiologie; patienten; patienten mit; pcr; peritonitis; persistieren; personal; personen; phase; plasma; pneumonie; pocken; polioviren; positiv; positiven; practice; praktisch; primaten; primär; primärinfektion; principles; proben; prognose; prophylaxe; protease; protein; prozesse; prävention; psittaci; punktat; qualifiziert; rahmen; reaktionen; rechnen; referenzzentren; regel; region; relativ; replikation; reservoir; resistent; resistenzen; respiratorische; risiko; risikogruppen; rna; robert; rolle; rrna; schlankes; schließlich; schlüsselliteratur; schmerzen; schmerzhafte; schnell; schon; schwangeren; schwangerschaft; schweinen; schweren; schäden; schützt; sehr; sein; selbst; selten; seltener; sepsis; sequenziert; sequenzierung; serologische; serotypen; serovare; serum; sich; sich bei; sich die; sich eine; sichtung; sie; siehe; simplex; sind; sind bei; sind für; sind keine; sind mit; sind nicht; sind und; sind von; sofern; sofort; sollten; somit; sondern; sowie; sowie der; sowie die; sowohl; speichel; speziellen; spezies; spezifische; spielen; spielt; sporen; spp; spricht; später; stadium; statt; stechmücken; stellen; stellt; stiche; studien; stuhl; stuhlproben; stunden; stäbchen; stäbchenbakterien; stämme; subtyp; symptomatik; symptome; syndrom; synonym(e; systemischen; tab; tage; taxonomy; teilweise; test; tetanus; therapie; therapie der; tieren; titer; tod; toxine; transmission; trinkwasser; tritt; tropenmedizinischen; trophozoiten; typischerweise; umwelteinflüsse; unbekannt; und; und auch; und auf; und bei; und der; und eine; und ist; und kann; und mit; und von; und zu; unklar; unter; unter der; unterbrechung; unterscheiden; unterschiedliche; untersucht; untersuchung; untersuchungsmaterial; unverzüglich; urin; ursache; usa; variabel; variabilität; verantwortlich; verbreitet; verbreitung; verdacht; verfahren; verfügbar; verfügung; verlauf; verlauf der; verlaufen; verläufe; vermehren; vermehrt; vermeidung; vermittelte; vermutlich; verschiedene; verursacht; verwendet; verzehr; viele; virale; virology; virulenz; virus; virusausscheidung; viruses; virusinfektion; virusreplikation; virämie; vitro; vollständig; vom; von; von anderen; von anti; von c.; von der; von infizierten; von menschen; vor; vorhanden; vorkommen; vorliegen; vorläuferprotein; wachstum; wahrscheinlich; web; weisen; weitere; welche; weltweit; weniger; wenn; werden; werden durch; werden können; werden mit; werden nicht; werden und; wichtige; wichtigsten; wie; wie bei; wird; wird durch; wird eine; wirksame; wirksamkeit; wobei; wochen; wundinfektionen; wurde; wächst; während; z. b.; zahl; zecken; zeichen; zeigen; zellen; zelluläre; zns; zu den; zu einer; zu können; zudem; zum; zumindest; zunächst; zur; zurückzuführen; zusammenhang; zusätzlich; zwar; zwei; zweiten; zwischen; ähnlich; älteren; übelkeit; über; über den; über die; übertragen werden; übertragung; überwiegend; üblichen
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46. cord-018545-fk17n2bx
    • author: Dorofaeff, Tavey
    • title: Infections in the PICU
    • date: 2012
    • words: 14182
    • flesch: 43
    • summary: Bronchiolitis and other viral respiratory infections in infants with congenital heart disease lead to operative delays and increasing complications post cardiac bypass surgery (e.g., pulmonary hypertension). The following groups are at increased risk of severe infection: • Ex-premature infants and neonates • Infants with congenital heart disease • Infants with immune deficiency • Infants with neuromuscular disease
    • keywords: acute; addition; adenovirus; admission; africa; agents; airway; amb; antibiotics; appropriate; areas; associated; aureus; bacterial; bleeding; blood; body; book; brain; broad; bronchiolitis; candida; cardiac; care; care unit; cases; catheter; causative; cause; cell; central; cerebral; chapter; chest; children; chronic; clinical; cmv; cns; common; community; congenital; countries; course; critical; csf; culture; days; deficiency; dengue; diagnosis; disease; dose; dysfunction; early; ebv; edema; endemic; epiglottitis; exposure; factors; failure; family; fever; following; fungal; fungi; general; good; gram; group; guidelines; hand; heart; high; higher; hiv; hospital; hsv; human; illness; immune; immunocompromised; important; incidence; increase; infants; infected; infections; inflammation; inflammatory; influenza; intensive; intensive care; intravenous; intubation; invasive; isolation; large; level; likely; line; liver; local; lower; lung; malaria; management; mechanical; meningitis; months; mortality; myocarditis; necrotizing; need; negative; neonates; neutropenia; non; normal; nosocomial; number; obstruction; occur; onset; organ; organisms; pain; pathogens; patients; pcr; pediatric; pericarditis; picu; place; pneumonia; pneumonitis; positive; post; present; pressure; prolonged; purulent; rate; related; renal; respiratory; review; risk; rsv; secondary; sepsis; serum; severe; severity; shock; significant; signs; similar; skin; species; specific; spectrum; streptococcus; stridor; support; supportive; surgery; surgical; symptoms; syndrome; systemic; therapy; time; tissue; toxic; tract; transplant; treatment; uao; unit; upper; urinary; ventilation; viral; virus; viruses; vomiting; weeks; world; wound; years
    • versions: original; plain text
47. cord-018659-rxzy6k3b
    • author: Danziger-Isakov, Lara
    • title: Posttransplant Complications and Comorbidities
    • date: 2018-01-08
    • words: 6906
    • flesch: 27
    • summary: Respiratory virus Bacteria account for about 50% of infections post lung transplant with pneumonia being most frequent. Obtaining cultures of respiratory, blood, urine, and wound samples with accurate identification and determination of drug sensitivity is critical in the treatment of bacterial infection post lung transplant.
    • keywords: adenovirus; adult; aeruginosa; allograft; antiviral; aspergillus; associated; bacterial; cases; cause; children; chronic; clinical; cmv; colonization; common; complications; consistent; cystic; cytomegalovirus; danziger; detection; diagnosis; disease; epidemiology; et al; factors; fibrosis; fungal; ganciclovir; human; identification; incidence; infection; influenza; international; intravenous; invasive; isakov; kotton; liu; lower; lung; lung transplant; lung transplantation; months; mortality; mrsa; multidrug; oral; organ; patients; pcr; pediatric; pediatric lung; pneumonia; population; positive; posttransplant; pretransplant; prevention; prophylaxis; pulmonary; recipients; resistant; respiratory; risk; rsv; severe; shoham; significant; solid; species; specific; studies; study; survival; symptoms; therapy; time; tract; transplant; transplant recipients; transplantation; treatment; valganciclovir; viral; viruses; years; young
    • versions: original; plain text
48. cord-018785-tcr5xlf8
    • author: Nambiar, Puja
    • title: Infection in Kidney Transplantation
    • date: 2018-06-27
    • words: 9374
    • flesch: 29
    • summary: A long national experience HIV-positive-to-HIV-positive kidney transplantation-results at 3-5 years Prevention and management of cytomegalovirus infection in solid-organ transplantation Prognosis of HTLV-I-positive renal transplant recipients Pre-emptive treatment for cytomegalovirus viraemia to prevent cytomegalovirus disease in solid organ transplant recipients Infections in solid-organ transplant patients Valganciclovir solid organ transplant study group: efficacy and safety of valganciclovir vs. oral ganciclovir for prevention of cyto-megalovirus disease in solid organ transplant recipients Fatal disseminated adenovirus infections in immunocompromised patients Polyoma nephropathy and progressive multifocal leukoencephalopathy in a renal transplant recipient CMV infection is associated with transplant renal artery stenosis Incisional surgical site infection in kidney transplantation BK virus in transplant recipients: an overview and update Transmission of human herpesvirus 8 infection from renal-transplant donors to recipients Impact of early cytomegalovirus infection and disease on longterm recipient and kidney graft survival RESITRA Network of the Spanish Study Group of Infection in Transplantation (2008) Impact of current transplantation management on the development of cytomegalovirus disease after renal transplantation Successful Treatment of Hepatitis C in Renal Transplant Recipients With Direct-Acting Antiviral Agents PHS guideline for reducing human immunodeficiency virus, hepatitis B virus, and hepatitis C virus transmission through organ transplantation Prevalence of HIV-associated nephropathy in autopsies of HIV-infected patients Human herpesvirus-6 in transplantation: an emerging pathogen Rates of first infection following kidney transplant in the United States Up to date Transmission of rabies virus from an organ donor to four transplant recipients Sirolimus for Kaposi's sarcoma in renal transplant recipients Outcomes of kidney transplantation in HIV-infected recipients Preemptive treatment for cytomegalovirus viremia to prevent cytomegalovirus disease in solid organ transplant recipients Viral infections affecting the skin in organ transplant recipients: epidemiology and current management strategies Long-term results in human T-cell leukemia virus type 1-positive renal transplant recipients Post-transplant lymphoproliferative disorders (PTLD) after solid organ transplantation The association of viral infection and chronic allograft nephropathy with graft dysfunction after renal transplantation Polyomavirus in kidney and kidney-pancreas transplant recipients Epidemiology of kidney disease in the unites states. CMV resistance to ganciclovir has been noted in renal transplant recipients due to mutations in UL 97, the gene responsible for the first phosphorylation step in ganciclovir activation and UL 54, the gene responsible for DNA polymerase (Limaye et al. 2000) .
    • keywords: active; acute; agents; allograft; antibody; antiviral; bacterial; bkv; blood; blumberg; brennan; candidates; cases; cause; cell; chronic; clinical; cmv; cmv disease; common; community; complications; cytomegalovirus; diabetes; diagnosis; disease; donor; dose; drug; early; ebv; et al; factors; following; ganciclovir; green; guidelines; hbv; hcv; hepatitis; herpesvirus; hhv; high; hiv; hsv; human; immune; immunosuppression; important; improved; incidence; infection; influenza; interactions; intravenous; karuthu; kdigo; kidney; latent; liver; lower; management; months; mortality; nat; nephropathy; nosocomial; options; oral; organ; organ transplant; organisms; outcomes; patel; pathogens; patients; paya; pneumonia; population; positive; posttransplant; preemptive; pretransplant; primary; prior; prophylaxis; ptld; reactivation; recipients; reduction; rejection; renal; renal transplant; resistant; risk; screening; solid; states; sulfamethoxazole; survival; testing; therapy; time; tract; transmission; transplant; transplant patients; transplant recipients; transplantation; treatment; trimethoprim; urinary; use; vaccination; vaccine; valganciclovir; viral; virus; viruses; vzv; weeks; weikert; wound; years
    • versions: original; plain text
49. cord-018943-5zf0eya3
    • author: Michels, Guido
    • title: Transplantationsmedizin in der Intensivmedizin
    • date: 2011-09-22
    • words: 400
    • flesch: 20
    • summary: The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients Therapeutic drug monitoring of mycophenolic acid after lung transplantation--is it clinically relevant Antifungal prophylaxis in liver transplant recipients Infection in organ-transplant recipients ACCF/AHA/ ACP/HFSA/ISHLT 2010 clinical competence statement on management of patients with advanced heart failure and cardiac transplant: a report of the ACCF/AHA/ACP Task Force on Clinical Competence and Training Consensusrecommendations for sirolimus in liver transplantation Update on lung transplantation Canadian Cardiovascular Society Consensus Conference update on cardiac transplantation 2008: Executive Summary focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation International consensus guidelines on the management of cytomegalovirus in solid organ transplantation Current concepts on cytomegalovirus infection after liver transplantation The survival benefit of liver transplantation Evaluation of the lung allocation score in highly urgent and urgent lung transplant candidates in Eurotransplant Alternatives to heart transplantation
    • keywords: cardiac; cmv; consensus; die; guidelines; heart; herztransplantation; international; liver; lung; management; nach; recipients; society; transplantation; und; von
    • versions: original; plain text
50. cord-019009-3ngfv96u
    • author: Gea-Banacloche, Juan
    • title: Risks and Epidemiology of Infections After Hematopoietic Stem Cell Transplantation
    • date: 2016-02-15
    • words: 8490
    • flesch: 23
    • summary: A multicenter, randomized trial Itraconazole versus fl uconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants Randomized, double-blind trial of fl uconazole versus voriconazole for prevention of invasive fungal infection after allogeneic hematopoietic cell transplantation Posaconazole or fl uconazole for prophylaxis in severe graft-versus-host disease Second-versus fi rstgeneration azoles for antifungal prophylaxis in hematology patients: a systematic review and meta-analysis Posaconazole vs. fl uconazole or itraconazole prophylaxis in patients with neutropenia Large-scale multiplex polymerase chain reaction assay for diagnosis of viral reactivations after allogeneic hematopoietic stem cell transplantation Intensive strategy to prevent cytomegalovirus disease in seropositive umbilical cord blood transplant recipients Long-term acyclovir for prevention of varicella zoster virus disease after allogeneic hematopoietic cell transplantation-a randomized double-blind placebo-controlled study Use of long-term suppressive acyclovir after hematopoietic stem-cell transplantation: impact on herpes simplex virus (HSV) disease and drug-resistant HSV disease Cytomegalovirus pp 65 antigenemia-guided early treatment with ganciclovir versus ganciclovir at engraftment after allogeneic marrow transplantation: a randomized double-blind study Risk factors for cytomegalovirus retinitis in patients with cytomegalovirus viremia after hematopoietic stem cell transplantation CMV central nervous system disease in stem-cell transplant recipients: an increasing complication of drug-resistant CMV infection and protracted immunodefi ciency Cytomegalovirus ventriculoencephalitis with compartmentalization of antiviral-resistant cytomegalovirus in a T cell-depleted haploidentical peripheral blood stem cell transplant recipient Transfusion-transmitted cytomegalovirus infection after receipt of leukoreduced blood products Successful modifi cation of a pp 65 antigenemia-based early treatment strategy for prevention of cytomegalovirus disease in allogeneic marrow transplant recipients Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and t-cell immunity Valganciclovir for the prevention of complications of late cytomegalovirus infection after allogeneic hematopoietic cell transplantation: a randomized trial The role of cytomegalovirus serostatus on outcome of hematopoietic stem cell transplantation Post-transplant lymphoproliferative disorders Prophylaxis of toxoplasmosis infection with pyrimethamine/sulfadoxine (fansidar) in bone marrow transplant recipients Risk factors for lymphoproliferative disorders after allogeneic hematopoietic cell transplantation EBV-associated post-transplant lymphoproliferative disorder after umbilical cord blood transplantation in adults with hematological diseases EBV-associated post-transplant lymphoproliferative disorder following in vivo t-cell-depleted allogeneic transplantation: clinical features, viral load correlates and prognostic factors in the rituximab era Impact of Epstein Barr virus-related complications after high-risk allo-SCT in the era of pre-emptive rituximab Human herpesvirus 6 infections after bone marrow transplantation: clinical and virologic manifestations High levels of human herpesvirus 6 DNA in peripheral blood leucocytes are correlated to platelet engraftment and disease in allogeneic stem cell transplant patients Clinical outcomes of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation Human herpesvirus 6 reactivation on the 30th day after allogeneic hematopoietic stem cell transplantation can predict grade 2-4 acute graft-versus-host disease Human herpesvirus-6 encephalitis after allogeneic hematopoietic cell transplantation: what we do and do not know Human herpesvirus 6 (HHV-6) reactivation and HHV-6 encephalitis after allogeneic hematopoietic cell transplantation: a multicenter, prospective study Frequent human herpesvirus-6 viremia but low incidence of encephalitis in double-unit cord blood recipients transplanted without antithymocyte globulin Foscarnet against human herpesvirus (HHV)-6 reactivation after allo-SCT: breakthrough HHV-6 encephalitis following antiviral prophylaxis Management of CMV, HHV-6, HHV-7 and kaposi-sarcoma herpesvirus (HHV-8) infections in patients with hematological malignancies and after SCT The challenge of respiratory virus infections in hematopoietic cell transplant recipients Risks and Epidemiology of Infections After Hematopoietic Stem Cell Transplantation with respiratory virus detection before allogeneic hematopoietic stem cell transplantation Respiratory syncytial virus lower respiratory disease in hematopoietic cell transplant recipients: viral RNA detection in blood, antiviral treatment, and clinical outcomes Parainfl uenza virus infections after hematopoietic stem cell transplantation: risk factors, response to antiviral therapy, and effect on transplant outcome Rhinovirus infections in hematopoietic stem cell transplant recipients with pneumonia Mortality rates of human metapneumovirus and respiratory syncytial virus lower respiratory tract infections in hematopoietic cell transplantation recipients Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients Disseminated bocavirus infection after stem cell transplant Infl uenza infections after hematopoietic stem cell transplantation: risk factors, mortality, and the effect of antiviral therapy Human parainfl uenza virus infection after hematopoietic stem cell transplantation: risk factors, management, mortality, and changes over time Airfl ow decline after myeloablative allogeneic hematopoietic cell transplantation: the role of community respiratory viruses Respiratory syncytial virus in hematopoietic cell transplant recipients: factors determining progression to lower respiratory tract disease Adenovirus infection and disease in pediatric hematopoietic stem cell transplant patients: clues for antiviral preemptive treatment Adenovirus infection rates in pediatric recipients of alternate donor allogeneic bone marrow transplants receiving either antithymocyte globulin (ATG) or alemtuzumab (campath) Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery Invasive adenoviral infections in t-celldepleted allogeneic hematopoietic stem cell transplantation: high mortality in the era of cidofovir Quantitative real-time polymerase chain reaction for detection of adenovirus after T cell-replete hematopoietic cell transplantation: viral load as a marker for invasive disease Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the infectious diseases working party of the European group for blood and marrow transplantation Polyomavirus BK infection in blood and marrow transplant recipients BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients Kidney and bladder outcomes in children with hemorrhagic cystitis and BK virus infection after allogeneic hematopoietic stem cell transplantation BK nephropathy in pediatric hematopoietic stem cell transplant recipients Pneumonitis post-haematopoeitic stem cell transplant-cytopathology clinches diagnosis JC polyomavirus reactivation is common following allogeneic stem cell transplantation and its preemptive detection may prevent lethal complications Pneumocystis carinii pneumonitis following bone marrow transplantation Occurrence of pneumocystis jiroveci pneumonia after allogeneic stem cell transplantation: a 6-year retrospective study Late onset pneumocystis carinii pneumonia following allogeneic bone marrow transplantation Infl uence of type of cancer and hematopoietic stem cell transplantation on clinical presentation of pneumocystis jiroveci pneumonia in cancer patients A randomized trial of daily and thrice-weekly trimethoprim-sulfamethoxazole for the prevention of pneumocystis carinii pneumonia in human immunodefi ciency virusinfected persons. Spanish group on infectious complications in hematopoietic transplantation Risk factors for invasive fungal infections in haematopoietic stem cell transplantation A controlled trial of fl uconazole to prevent fungal infections in patients undergoing bone marrow transplantation Effi cacy and safety of fl uconazole prophylaxis for fungal infections after marrow transplantation-a prospective, randomized, double-blind study Candidemia in allogeneic blood and marrow transplant recipients: evolution of risk factors after the adoption of prophylactic fl uconazole Epidemiology of aspergillus infections in a large cohort of patients undergoing bone marrow transplantation Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors Invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplantation after nonmyeloablative conditioning: risks and outcomes Risks, diagnosis and outcomes of invasive fungal infections in haematopoietic stem cell transplant recipients Epidemiology and outcomes of invasive fungal infections in allogeneic haematopoietic stem cell transplant recipients in the era of antifungal prophylaxis: a singlecentre study with focus on emerging pathogens Zygomycosis in a tertiary-care cancer center in the era of aspergillus-active antifungal therapy: a casecontrol observational study of 27 recent cases Micafungin versus fl uconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation Prolonged fl uconazole prophylaxis is associated with persistent protection against candidiasis-related death in allogeneic marrow transplant recipients: long-term follow-up of a randomized, placebo-controlled trial Intravenous and oral itraconazole versus intravenous and oral fl uconazole for long-term antifungal prophylaxis in allogeneic hematopoietic stem-cell transplant recipients.
    • keywords: active; acute; adenovirus; allogeneic; allogeneic hematopoietic; antifungal; aspergillosis; associated; bacteremia; bacterial; blood; bone; cancer; cases; cause; cell; cell transplantation; chronic; clinical; cmv; common; complications; conditioning; cord; cytomegalovirus; day; depletion; different; disease; donor; early; ebv; encephalitis; engraftment; epidemiology; european; factors; following; fungal; group; guidelines; gvhd; hct; hematopoietic; hematopoietic cell; hematopoietic stem; herpesvirus; high; hla; host; human; immunosuppression; infections; infl; invasive; late; leukemia; like; management; marrow; monitoring; mortality; neutropenia; outcomes; patients; period; pneumocystis; pneumonia; post; posttransplant; presence; prevention; prior; prolonged; prophylaxis; randomized; reactivation; recipients; regimen; related; resistant; respiratory; risk; role; signifi; stem; stem cell; strategy; study; t cell; term; time; toxoplasmosis; transplant recipients; transplantation; transplants; treatment; trial; uconazole; uenza; use; variety; viral; virus
    • versions: original; plain text
51. cord-021977-yu0hrg6h
    • author: Pham, Phuong-Thu T.
    • title: Medical Management of the Kidney Transplant Recipient: Infections and Malignant Neoplasms
    • date: 2010-12-27
    • words: 6931
    • flesch: 30
    • summary: CMV infection occurs primarily after the first month of transplantation and continues to be a significant cause of morbidity in the first 6 months after organ transplantation through both direct and indirect effects. CMV infection may be asymptomatic, presenting as a mononucleosis-like syndrome or influenza-like illness with fever and leukopenia or thrombocytopenia, or a severe systemic disease.
    • keywords: active; acute; acyclovir; agents; allograft; antibody; antilymphocyte; associated; bacterial; cancer; candida; cause; cell; centers; clinical; cmv; cmv infection; colonic; common; complications; cyclosporine; daily; diagnosis; diarrhea; disease; donor; dose; early; ebv; effective; effects; everyday; exposure; factors; figure; gastrointestinal; general; graft; hbv; hcv; hepatitis; high; history; hsv; human; immunosuppression; incidence; infections; intravenous; kidney; lesions; lymphoma; malignant; management; mmf; months; neoplasms; nephropathy; occur; opportunistic; oral; organ; patients; period; population; post; primary; prophylactic; prophylaxis; ptld; pylori; rates; reactivation; recipients; reduction; rejection; renal; renal transplant; response; risk; seropositive; sirolimus; skin; solid; studies; symptoms; tacrolimus; therapy; tract; transplant recipients; transplantation; treatment; urinary; use; utis; valganciclovir; viral; viremia; virus; weeks; years
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52. cord-022472-q2qtl26d
    • author: Fishman, Jay A.
    • title: Infection in Renal Transplant Recipients
    • date: 2009-05-15
    • words: 10762
    • flesch: 32
    • summary: Fever and neutropenia syndrome with features of infectious mononucleosis, including hepatitis, nephritis, leukopenia, and/or thrombocytopenia • Pneumonia • Gastrointestinal invasion with colitis, esophagitis, gastritis, ulcers, bleeding, or perforation • Hepatitis, pancreatitis, chorioretinitis With the exception of chorioretinitis, the direct clinical manifestations of CMV infection usually occur 1 to 4 months after transplantation; chorioretinitis usually does not begin until later in the transplant course. CMV infection produces a profound suppression of a variety of host defenses, predisposing to secondary invasion by such pathogens as P. jiroveci, Candida and Aspergillus species, and some bacterial infections.
    • keywords: absence; active; acute; agents; aids; allograft; antimicrobial; antiviral; aspergillus; assays; barr; blood; broad; calcineurin; candida; cells; centers; central; chest; chronic; clinical; cmv; cmv infection; common; community; cytomegalovirus; diagnosis; disease; donor; dose; drug; dysfunction; ebv; endemic; epstein; evaluation; exposures; factors; fever; fluconazole; function; fungal; general; group; guidelines; hbv; hcv; hepatitis; high; hiv; human; immune; immune suppression; immunocompromised; immunosuppressive; important; incidence; individuals; infected; infection; invasive; jiroveci; kidney; latent; levels; load; lymphoproliferative; management; months; negative; nephropathy; nosocomial; opportunistic; organ; organisms; pathogens; patients; period; pneumocystis; pneumonia; polyomavirus; positive; possible; post; presence; present; prevention; primary; prior; prolonged; prophylaxis; ptld; quantitative; radiograph; recipients; reduction; rejection; renal; renal transplant; resistant; respiratory; response; result; risk; role; routine; screening; seropositive; significant; skin; solid; species; specific; spectrum; strategies; suppression; surgery; syndrome; systemic; table; therapies; therapy; time; tissues; toxicity; transplant; transplant recipients; transplantation; treatment; trimethoprim; tuberculosis; type; urinary; urine; use; useful; variety; vascular; viral; virus; viruses
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53. cord-022752-bdve1ydv
    • author: Knuf, Markus
    • title: Infektiologie
    • date: 2019-08-09
    • words: 26045
    • flesch: 38
    • summary: Scharlach ist von der unkomplizierten Tonsillopharyngitis abzugrenzen (› Abb. 10.9). Nach Abklingen der akuten Symptome bei EHEC-Infektionen verkürzt es die Phase der asymptomatischen Ausscheidung.
    • keywords: 0,5; abb; aber; abhängig; abs; abstrich; aciclovir; actinomyces; adenoviren; aeruginosa; aim; aktive; aktivität; aktuellen; akuten; allem; allem bei; allerdings; allgemeine; allgemeinzustand; als; alternativ; ambulant; amoxicillin; amphotericin; amöbiasis; anaerobier; analyse; anamnese; anderen; angeborenen; angegeben; angestrebt; angewendet; angezeigt; anhaltendem; antibiotika; antibiotikums; antigen; antiinfektiva; antikörper; anwendung; aom; arten; arthritis; arzt; aspergillus; atemwegsinfektionen; auch; auch bei; auch mit; auch nach; auf; auf das; auf den; auf eine; aufgrund; auftreten; auftritt; aureus; aus; aus der; ausbrüche; ausgeprägten; ausmaß; ausnahme; ausschließlich; auswahl; azithromycin; b. bei; bakterielle; bakterien; bakterium; bal; basishygiene; bauchschmerzen; bedeutung; befunde; beginn; begonnen; behandelt; behandelt werden; behandlung; behandlung ist; behandlung von; bei; bei der; bei einer; bei kindern; bei neugeborenen; bei nicht; bei säuglingen; beide; beim; beispiele; bekannt; beobachten; bereich; bereits; berücksichtigen; beschrieben; besiedelung; besonders; besprochen; bestehen; besteht; besteht eine; bestimmten; betalaktam; betroffen; beträgt; bevorzugt; bevölkerungsgruppe; bezeichnet; bezug; bezüglich; bezüglich der; bild; bild der; biomarker; bioverfügbarkeit; bis; bis zu; bislang; blut; blutbild; bordetella; borrelien; bronchitis; burgdorferi; bzw; campylobacter; candida; candidiasis; cd4; cefotaxim; ceftriaxon; cephalosporine; cephalosporine der; charakteristisch; chemoprophylaxe; chirurgische; chlamydia; chronische; clarithromycin; clavulansäure; clindamycin; cmv; coli; corynebacterium; crp; daher; damit; daneben; dann; dar; darüber; das; das klinische; dass; daten; dazu; definierten; dem; denkbar; denken; der; der akuten; der einsatz; der erkrankung; der erreger; der geburt; der gruppe; der impfung; der influenza; der kinder; der mensch; der nachweis; der pädiatrie; der regel; der schleimhäute; der symptome; der wahl; dermatophyten; des; deutlich; deutschland; deutschland ist; diagnose; diagnose der; diagnose die; diagnose einer; diagnose wird; diagnostik; diagnostische; diagnostiziert; die; die behandlung; die inzidenz; die mit; die prävalenz; diese; differenzialdiagnostisch; differenzierung; diphtherie; direkten; dna; dokumentiert; dosierung; dosis; doxycyclin; drei; durch; durch den; durch die; durch eine; durchgeführt; early; ebv; echinokokkose; eine; eine akute; eine bakterielle; eine infektion; eine spezifische; eine therapie; einführung; einführung der; eingesetzt; eingesetzt werden; einher; einige; einsatz; einsatz von; einwohner; elisa; empfehlungen; empfindlichkeit; empfohlen; enterokokken; enteroviren; enthalten; entstehen; entwickelt; entzündung; enzephalitis; epidemie; epidemiologie; ereignisse; erfassung; erfolgen; erfolgt; erforderlich; ergebnisse; erhalten; erkrankte; erkrankung; ermittelt; erreger; erreger sind; erregernachweis; erreicht; ersten; erwachsenen; erworbenen; erythema; erythromycin; es bei; es besteht; es die; es ist; es sind; es wird; es zu; etwa; etwaigen; europa; exanthem; exponierten; exposition; expositionsprophylaxe; fall; familie; fazialisparese; ferner; fibrose; fieber; fieber und; findet; fluconazol; folgende; form; formen; frauen; früher; frühgeborenen; fälle; führen; für; für das; für den; für die; für eine; gabe; gas; gbs; geburt; geeignet; gegen; gegensatz; gegenüber; geht; gehören; gehört; gelingt; gemeldet; genannt; genitalen; genitalis; genotypen; gentamicin; gering; gesichert; gestellt; gewebe; ggf; gibt; gilt; gonokokken; gramnegative; grampositive; granulozyten; grundlagen; grundsätzlich; gruppe; gut; gute; haben; haemophilus; hat; hat eine; haut; hcv; hefepilze; hepatitis; hepatosplenomegalie; herbst; herpes; hervorgerufen; hib; hier; hierbei; hierfür; hierzu; hilfreich; hinsichtlich; hinsichtlich der; hiv; hoch; hohe; hpv; hsv; hsv2; humanpathogenen; husten; hämagglutinin; hämolysierende; händedesinfektion; hängt; häufig; häufigkeit; häufigsten; identifiziert; ifsg; igg; igm; ihrer; immer; immundefekte; immundefizienz; immunisierung; immunität; immunsuppression; immunsupprimierten; immunsystems; impfstoffe; impfung; impfungen; indikation; indiziert; infektiologischen; infektion; infektion bei; infektion ist; infektion kann; infektion wird; infektionen der; infektionen können; infektionen mit; infektionen werden; infektionskrankheiten; infektiosität; infektiöse; influenza; inkl; inkubationszeit; innerhalb; insbesondere; insbesondere bei; invasive; inzidenz; ist; ist als; ist auch; ist bei; ist das; ist der; ist die; ist eine; ist für; ist mit; ist möglich; ist nach; ist nicht; ist nur; ist von; ist zu; itraconazol; jahren; jedoch; jugendalter; jugendlichen; jungen; jährlich; kann; kann bei; kann der; kann die; kann durch; kann eine; kann es; kann mit; kann zu; katzenkratzkrankheit; kaum; kein; keuchhusten; kg kg; kg von; kindern; kindern mit; kindern und; kindesalter; kleinkindern; klinik; klinische; knowlesi; kombination; kombinationstherapie; kommen; kommt; kommt es; komplikationen; konjunktivitis; konnatalen; konnten; kontakt; kopfschmerzen; krankheitsbild; kutanen; können; können als; labor; lang; lassen; lebensjahr; leber; leishmania; leishmaniose; leitlinie; letalität; liegen; liegt; liegt bei; liquor; listerien; lokale; lyme; lymphadenitis; länger; läsionen; lässt; makrolide; malaria; man; manifestationen; masern; maßnahmen; maßnahmen der; media; medikamenten; medizinische; mehr; mehrere; meist; meisten; meldepflicht; meningitis; meningokokken; mensch; mensch ist; mensch zu; menschen; methoden; mikrobiologischen; mindestens; mit; mit der; mit einer; mittel der; mittels; monaten; mrsa; muss; mutter; möglich; möglichst; müssen; nach; nach der; nach einer; nachgewiesen; nachweis; nachweis von; nachweisbar; nahezu; nasen; neben; neben der; nebenwirkungen; nennen; neugeborenen; neugeborenenkonjunktivitis; neuraminidase; neuroborreliose; nicht; nicht mit; nicht zur; noch; nosokomiale; notwendig; nur; nur bei; oder; oder der; oder die; oder durch; oder einer; oder mit; oft; oftmals; ohne; onkologie; onset; orale; organe; osteomyelitis; otitis; pallidum; pandemie; parasiten; parenteral; patienten; patienten mit; pcap; pcr; penicillin; persistieren; personen; pertussis; pilzinfektionen; pneumokokken; pneumonie; positiven; praktisch; primärinfektion; prophylaxe; prävalenz; prävention; pseudomonas; pulmonale; pädiatrie; rachen; reaktionen; reaktivierung; regel; regionen; reservoir; resistente; respiratorische; risiko; risikofaktoren; rki; rolle; rsv; rötung; scharlach; schleimhäute; schutz; schwangeren; schwangerschaft; schwellung; schweren; sehr; sein; selten; seltener; sensitivität; sepsis; serologie; serologische; serotypen; serum; sexuellen; sich; sich bei; sich der; sich die; sich eine; sie; sind; sind auch; sind bei; sind eine; sind für; sind nicht; sinnvoll; sinusitis; sodass; sog; solche; sollen; sollte; sondern; sowie; sowie der; sowie die; sowohl; spezies; spezifische; spezifität; spielen; spp; spricht; später; ssw; stadium; standardimpfung; staphylococcus; staphylokokken; stationären; stehen; stellen; stiko; streptokokken; streptokokken der; strukturen; studien; stuhl; stämme; substanzen; subtypen; sulbactam; symptomatik; symptomatischen; symptome; syndrom; syphilis; systemischen; säuglingen; säuglingen und; säuglingsalter; südamerika; tab; tage; talspiegel; teicoplanin; teil; tertiana; test; therapeutisch; therapie; therapie der; therapie mit; therapie von; tinea; tod; tonsillopharyngitis; trachomatis; treponema; tritt; tropica; typen; typische; typischerweise; und; und bei; und das; und der; und die; und eine; und ist; und jugendlichen; und kann; und kleinkindern; und sind; und therapie; und wird; und zur; unspezifisch; unter; unter der; unterscheidet; unterschieden; unterschiedliche; untersuchungen; urin; ursache; vancomycin; variabel; varizellen; verabreicht; verantwortlich; verbreitet; verfahren; verfügen; verfügung; vergleich; verhinderung; verlauf; verletzung; vermehrt; verordnet; verschiedene; verursacht; verwendet; verwiesen; viele; vielzahl; viralen; viren; virostatika; virus; vom; von; von der; von einer; von mensch; vor; vor allem; voraussetzungen; vorbereitung; vordergrund; vorgehen; vorhersagewert; voriconazol; vorkommen; vorkommt; vorwiegend; vorzugsweise; vzv; wahl; wahrscheinlich; warzen; wegen der; weisen; weitere; weltweit; weniger; wenn; werden; werden bei; werden die; werden durch; werden kann; werden können; werden und; wesentlich; wichtige; wichtigsten; wieder; windpocken; winter; wird; wird auf; wird bei; wird der; wird durch; wird eine; wird mit; wird von; wirksam; wirksamkeit; wirkspektrum; wirt; wobei; wochen; wurde; während; yersinien; z. b.; zahl; zeichen; zeitpunkt; zns; zoonosen; zoster; zu den; zu einer; zugelassen; zuletzt; zum; zunächst; zur; zur behandlung; zur diagnose; zur therapie; zur verfügung; zusammenarbeit; zusammenhang; zusammenhang mit; zusätzlich; zuverlässig; zuvor; zwei; zwischen; zysten; zystische; ähnlich; über; über eine; übertragung; übertragung und; überwiegend
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54. cord-022888-dnsdg04n
    • author: None
    • title: Poster Sessions
    • date: 2009-08-19
    • words: 189173
    • flesch: 41
    • summary: Our aim is to describe how B cell lymphoma cells respond to TGF-b compared to normal peripheral B cells, to create an overview of the different signaling pathways involved, and to characterize the mechanisms behind the loss of sensitivity to TGF-b. Methods: Proliferation assays were performed on 11 different B-cell lymphoma cell lines and normal peripheral B cells to screen for TGF-b-induced effects. Using a CD3 and CD28 activation model system -TLR4 presence on CD4+ cells is found in mouse T cells, human T cells and Jurkat cell lines.
    • keywords: + +; + /+; + cells; 1,2; a*0201; a549 cells; ab t; ability; able; absence; absent; accessibility; accumulation; acid; actin; activated; active; activities; activity; acute; ad5; adaptive; adaptive immune; adaptor; addition; adenoviral; adhesion; adipocytes; adjuvant; administration; adp; adult; affect; affected; affinity; afp; agents; aggrecan; agonist; aim; aims; airway; akt; allele; allergens; allergic; alpha; alterations; altered; alternative; amino; amounts; analyse; analysis; anergy; animals; antagonist; antibodies; antibody; antibody response; antigen; antigen expression; antigen presentation; antigen receptor; antigen specific; antigenic; antiviral; apc; apcs; apoptosis; apoptotic cells; approach; appropriate; area; arthritis; asc; aspects; assay; associated; association; asthma; atherosclerosis; atp; attenuated; aureus; autoantibodies; autoantibody; autoimmune; autoimmunity; autologous; autophagy; autoreactive; available; avidity; b cells; b lymphocytes; b t; b-1 cells; b27; background; bacterial; baff; balb; basal; baseline; basis; basophils; bcg; bcl-2; bcr; berlin; beta; better; binding; biochemical; biological; biology; biopsies; blocking; blood; blood cells; blot; blotting; bone; boost; bowel; brain; breast; broad; burst; c mice; c57bl/6; caga; calcineurin; calcium; cancer cells; candidate; capable; capacity; carabin; carkl; cascade; cases; caspase; caspase-1; catalytic; cause; cbl; cd11b; cd14; cd152; cd16; cd19; cd1a; cd1d; cd25; cd28; cd3; cd36; cd4; cd40; cd45; cd5; cd56; cd69; cd8 +; cd8 cells; cd8 t; cd80; cd86; cd8a; cell activation; cell activity; cell antigen; cell biology; cell compartment; cell contact; cell culture; cell cycle; cell cytokine; cell cytotoxicity; cell death; cell degranulation; cell depletion; cell development; cell differentiation; cell epitopes; cell expansion; cell function; cell growth; cell help; cell homeostasis; cell hybridomas; cell immunity; cell influx; cell interaction; cell level; cell lines; cell lymphoma; cell lysates; cell maturation; cell membrane; cell number; cell phenotype; cell population; cell priming; cell production; cell proliferation; cell receptor; cell recognition; cell recruitment; cell repertoire; cell responses; cell signaling; cell sorting; cell stimulation; cell subsets; cell supernatant; cell surface; cell survival; cell tolerance; cell transfer; cell transplantation; cell types; cells cells; cells co; cells incubation; cells present; cells specific; cellular immune; center; central; certain; cfse; cgd; chain; challenge; changes; channels; characteristics; characterization; characterized; chemokines; chemotaxis; children; chimeric; chip; chitosan; cholesterol; chop10; chromatin; chromosome; chronic; cht; class; classical; clearance; cleavage; clinical; clones; close; cmv; cns; coated; cohort; colitis; collagen; colon; combination; combined; common; comparable; comparison; complement; complete; complex; complexes; components; composition; compounds; concentrations; conclusion; conditions; confocal; conjugate; consequences; conserved; consistent; constitutively; contact; context; contrary; contrast; contribute; contribution; control; control cells; control mice; controlling; conventional t; cord; coro1a; coronin-1; correlated; correlation; corresponding; course; cpg; criteria; critical; crohn; cross; crosstalk; crp; crt; crtam; crucial; csf; csk; ct26; ctl; ctla-4; ctls; cultured; current; cutaneous; cytokine; cytokine expression; cytokine levels; cytokine production; cytokine response; cytometry; cytoplasmic; cytoskeleton; cytosolic; cytotoxic t; damage; dasatinib; data; day; days; dcs; decreased; defective; defects; defense; deficiency; deficient cells; deficient mice; degradation; degree; delivery; delta t; dendritic cells; density; department; dependent; dependent cell; depleted; depletion; design; detail; detailed; detectable; detection; determination; determined; developmental; diabetes; diagnosis; differences; different; different cell; differential; differentiated; diminished; direct; disease; disorders; display; distinct; distribution; diverse; division; dna; domain; dominant; donors; dose; double; downregulation; downstream; draining; drb1; drugs; dsrna; dss; dynamics; early; early t; ebpb; ebv; effective; effector cells; effector t; effects; efficacy; efficient; efhd2; elements; elevated; elimination; elisa; elispot; embryonic; encoding; endosomal; endothelial; engagement; enhanced; enhancement; enhancing; enrichment; enzyme; eosinophils; epidermal; epidermis; epithelial cells; epithelium; eraap; erap1; erk1/2; erp57; erythematosus; escape; essential; ev71; evaluated; evaluation; events; evidence; example; exhibit; exogenous; exon; exosomes; expansion; experiments; exposed; exposure; expressed; expression; expression levels; expression system; extended; extent; extract; facs; factor; factor t; failure; family; far; fasl; fcgriib; features; feeding; female; ferritin; fetal; fibroblasts; fibrosis; findings; flow; fluorescence; foam cells; fold; following; formation; foxp3; fraction; fragment; free; frequencies; frequency; frequent; function; fusion; future; fviii; g t; galcer; gamma; gammadelta t; gastrointestinal; gcs; gd cells; gd t; gdcd8; gel; gene; gene expression; general; generation; genetic; genome; genomic; genotype; germany; gfp; glioma cells; glycoprotein; glycosylation; goal; good; gp120; grade; gram; grant; granules; granulocytes; granzyme; grb; greater; group; growth; gut; h5n1; ha-1; haart; hadv; half; hand; hcv; hdl; hdm; healing; healthy; heat; heavy; hek cells; helper cells; hematopoietic cells; heme; hepatitis; hi cells; high; high expression; high levels; high t; higher; highest; histamine; histological; history; hiv; hiv-1; hla; hla class; hmb; hmgb1; hospital; host; host immune; hours; hrs cells; hscs; hsp70; human b; human cd4; human cells; human peripheral; human t; humans; humoral; hybridomas; hypothesis; ibd; icam-1; icos; identification; iel; ifn; ifnar; ifnb; ifng; igg; igg1; igm; igsf4; ii t; il-10; il-12p40; il-1b expression; il-1ra; il-2; il-33; il-4; il-5; il-6; il-7; il-8; imaging; immature; immune activation; immune cells; immune regulation; immune response; immune system; immunity; immunization; immunized; immunocompetent cells; immunodeficiency; immunodominant; immunofluorescence; immunogenicity; immunoglobulin; immunological; immunology; immunomodulatory; immunoprecipitation; immunoproteasomes; immunosuppression; immunotherapy; impact; impaired; implications; important; important role; improved; inactivation; inactive; incidence; incorporation; increased; increasing; incubation; individuals; induced; induced cell; inducible; induction; infants; infected cells; infected mice; infection; infiltrates; infiltration; inflamed; inflammation; inflammatory; inflammatory cells; inflammatory cytokines; inflammatory immune; inflammatory response; influence; influenza; influx; inhibited; inhibition; inhibitory; inhibits; initial; initiation; injury; inkt; inkt cell; inkt17 cells; innate; innate immune; innate t; insights; institute; intact; intensity; interaction; interest; interesting; interference; interferon; interleukin; intermediate; internalization; intestinal; intracellular; intraepithelial; intranasal; introduction; invariant; investigation; involved; involvement; isoforms; isolated; isolation; isotype; italy; jab1; jam; jnk; jurkat cells; jurkat t; kda; keratinocytes; key; killer cells; killer t; killing; kinase; kinetics; kit; knock; knockdown; knockout; knowledge; ko mice; kupffer cells; laboratory; lack; lamina; langerhans cells; large; latent; later; lck; lcmv; leishmania; length; leprae; lesions; lethal; leukemia; leukemic cells; leukemic t; leukocytes; levels; ligand; ligation; light; like; likely; limited; lineage cells; lineages; link; lipid; listeria; little; liver; lmp2; lmp7; lnk; loaded; loading; local; localization; locus; long; loss; low cells; lower; lp(a; lpr; lps; lsec; lung; lupus; lymphoid cells; lymphoma; mab; mabs; macrophage cell; macrophages; mainly; maintenance; major; majority; malaria; male; malignant cells; manipulation; manner; mapk; marked; markers; marrow cells; mass; mast cells; matrix; maturation; mature; mature b; mature cells; mcl-1; mcmv; mcs; mdp; mdsc; mean; measles; measure; measurement; mechanisms; mediated; mediators; medical; medicine; medium; medullary; melanoma cells; members; membrane; memory b; memory cells; memory t; methods; mhc; mhc class; mhcii; mice; microarray; microbial; microcapsules; microenvironment; microglia; microscopy; migration; milk; minimal; minor; minutes; mirnas; mitochondrial; mixed; model; moderate; modified; modulation; molecular; molecules; monoclonal; monocytes; monocytic cells; monocytogenes; mononuclear cells; months; mortality; mothers; mouse; mouse t; mrna; mucosal; multiple; murine; murine t; mutant; mutations; mva; mycn; mycobacteria; myd88; myeloid cells; naive; naive t; nanoparticles; national; natural; naï; nck; ncs; necessary; necrosis; necrotic cells; need; nef; nef138; negative; neonatal; neopterin; nets; network; neuroblastoma cells; neuronal cells; neutralization; neutralizing; neutrophils; new; newborn; nfat; nfatc1; nfkb; nfxb; nitric; nk cell; nk t; nkg2d; nkt cells; nod mice; node t; nodes; normal; normal t; novel; ns3; nucleotide; null t; number; numerous; objectives; observation; observed; onset; opn; optimal; optimal t; order; organ; organization; origin; outcome; ova; ovalbumin; overall; overexpression; oxidative; oxide; p110; p14 t; p1c; p24; p38; p53; panel; parameters; parasite; parasitic; partial; participate; particles; particular; pathogenesis; pathogens; pathological; pathology; pathway; patients; pattern; pbmc; pcr; pd-1; pdc; peak; peptide; percentage; period; peripheral; peripheral blood; peritoneal; peritoneal cells; persistent; pge; pgp; phagocytes; phagocytosis; phase; phenomenon; phenotype; phosphatase; phosphorylation; physiological; pi3k; pivotal; pkc; place; placebo; plasma cells; play; plc; plus; pma; pneumoniae; point; polarization; polarized; pollen; poly(i; polyclonal; polymorphisms; pool; populations; position; positive cells; positive t; possibility; possible; post; potential; pparg; precursor; preliminary; prepared; presence; present study; presentation; presenting; pretreatment; prevents; previous; primary; primary cells; primary t; primed; priming; prior; process; processes; processing; producers; producing; production; products; profile; profound; progenitor cells; progenitors; program; progression; project; proliferative; prominent; promising; promoter; prone; properties; proportion; proteasome; protective; protein; protein expression; protein levels; protein production; proteolytic; protocol; provide; psoriasis; pta; ptx3; pulmonary; pulsed; purified; purpose; putative; pylori; quality; quantitative; quantity; question; rac1; range; rapid; rats; rbl-2h3 cells; reaction; reactive; real; rearrangements; recent; receptor expression; receptors; recipients; recognition; recombinant; recruitment; reduced; reg cells; region; regulated; regulation; regulators; regulatory cells; regulatory role; regulatory t; related; relationship; relative; release; relevance; relevant; remains; remission; repertoire; replication; reported; required; research; resident; resident cells; residues; resistance; respect; respiratory; responder; responsible; responsiveness; resting; restricted; results; reticulum; reverse; rhdv; rich; rise; risk; rma cells; rnai; robust; role; roquin; route; rsv; s1p; salivary; samples; samsn1; sarcoidosis; scanning; school; sciences; sclerosis; seasonal; second; secondary; secrete; secretion; secretory; selected; selection; selective; self; sensitive; sensitivity; separated; sepsis; sequence; sera; serum; severe; severity; sh3; shock; short; shrna; signaling; signals; significantly; similar; simultaneous; single cell; site; size; skin; slc; sle; sle patients; sly2; small; smurf2; snps; socs1; soluble; sortilin; sorting; source; spain; species; specific activation; specific antibodies; specific b; specific cd8; specific expression; specific immune; specific responses; specific role; specific t; spectrometry; spleen cells; splenic; splenocytes; splicing; spontaneous; src; ssc; stability; stable; stages; staining; standard; stat6; statistical; status; steady; stem cells; step; stimulated; stimulated cells; stimulation; stimulatory; stimuli; stimulus; strain; strategies; strategy; strength; stress; stromal cells; strong; structural; student t; studies; study; studying; subcellular; subcutaneous; subjects; subpopulations; subsequent; substantial; substrate; subtypes; subunit; successful; suffering; summary; supernatants; support; suppression; surface expression; surgery; surveillance; survival; survivin; susceptibility; susceptible; sustained; swap-70; swiprosin-1; switch; syk; symptoms; synapse; syndrome; synthesis; synthetic; system; systemic; t activation; t cells; t em; t h; t helper; t lineage; t lines; t lymphocytes; t reg; t test; tap1; tap2; tapasin; target cells; targeted; targeting; targets; tcr; tcrab; tcrgd; technique; technology; tecs; teff cells; terminal; terminus; terms; tested; tests; tgf; tgfb1; th1 cells; th17; th2; th2 cell; therapeutic; therapies; therapy; thymic; thymic cells; thymocytes; thymus; time; tissue; titers; tlr; tlr2; tlr3; tlr4; tlr7; tlr9; tlrs; tnc.1 cells; tnf; tnfa; tolerance; tolerogenic; toll; tool; total; trail; transcription; transcripts; transduction; transfer; transgenic; transgenic mice; transient; translocation; transmembrane; transport; treatment; tregs; trials; triggering; triggers; tuberculosis; tumor cells; tumors; tumour; turnover; type; type b; type mice; typical; tyrosine; u937 cells; ubiquitin; ulcerative; unclear; unconventional t; underlying; understanding; understood; uninfected; unique; united; university; unknown; untreated; upa; uptake; us3; useful; uty; vaccinated; vaccination; vaccine; vaccinia; vacv; values; variable; variants; variety; vascular; vector; vegf; venous cells; versus; vesicles; vg9vd2 t; vgamma9vdelta2 t; viral; virulent; virus; viruses; vitro; vivo; vivo t; vlps; volunteers; weeks; wehi231 cells; weight; western; whitney; wide; wild; wildtype; wnt; work; years; zfp36l1
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55. cord-023669-3ataw6gy
    • author: Masur, Henry
    • title: Critically Ill Immunosuppressed Host
    • date: 2009-05-15
    • words: 11198
    • flesch: 30
    • summary: HIV patients pose a risk to health care professionals, however. For such patients, mucormycosis and non-albicans Candida are becoming more prominent causes of morbidity.
    • keywords: aerobic; agents; ammatory; amphotericin; antibacterial; antifungal; antimicrobial; antiretroviral; appropriate; attention; bacterial; barriers; blood; broad; cancer; candida; care; carinii; catheter; causative; cause; cd4; cells/µl; certain; ciency; clinical; clinicians; cmv; cocci; combination; common; complications; corticosteroids; count; cytomegalovirus; days; diagnosis; diffuse; disease; drugs; empiric; evaluation; factors; failure; febrile; fever; frequency; function; fungal; fungi; gram; haart; health; high; hiv; hiv infection; host; human; icu; icus; identifi; immune; immunocompromised; immunodefi; immunologic; immunosuppressed; important; induced; infected; infection; infl; initial; laboratory; likely; lymphocyte; major; management; manifestations; mechanisms; multiple; need; negative; neutropenia; neutrophil; normal; number; opportunistic; opportunistic infections; oral; organ; organisms; pathogens; patients; pcp; pneumocystis; pneumonia; population; positive; present; processes; prophylactic; prophylaxis; pulmonary; recipients; regimens; resistant; respiratory; response; result; risk; severe; solid; specifi; spectrum; sputum; status; study; substantial; survival; susceptibility; susceptible; syndrome; therapy; transplant; transplantation; treatment; tuberculosis; uconazole; useful; virus; viruses
    • versions: original; plain text
56. cord-023729-dipjubn7
    • author: Serlin, Michael H.
    • title: Gastrointestinal Disorders in HIV
    • date: 2009-05-15
    • words: 5864
    • flesch: 40
    • summary: Pneumocystis jiroveci (PCP) can also be seen as the cause of diarrhea in HIV patients, but is very uncommon, especially in the setting of PCP prophylaxis for AIDS patients; treatment is with antipneumocystis therapy, 38 generally with trimethoprim-sulfamethoxazole. Patients can have both dysphagia and odynophagia, and because they also may have more than one illness concurrently, it is imperative to pursue a thorough investigation as to the etiology of esophageal complaints in HIV patients.
    • keywords: acyclovir; addition; aids; anal; anorectal; art; associated; biopsy; candida; candidiasis; cases; cause; cd4; chronic; ciency; cile; clinical; cmv; colitis; common; complaints; count; culture; daily; day; days; diagnosis; diarrhea; diffi; disease; dysphagia; endoscopy; enteritis; esophageal; esophagitis; etiologies; etiology; foscarnet; fungal; ganciclovir; gastrointestinal; history; hiv; hiv patients; human; ieu; illness; immunodefi; incidence; infections; lymphocyte; mai; medications; odynophagia; opportunistic; oral; pain; patients; physical; related; stool; studies; study; symptoms; syndrome; therapy; treatment; uconazole; ulcers; viral; virus
    • versions: original; plain text
57. cord-023854-w8kx5n8k
    • author: Schuster, V.
    • title: Virusinfektionen
    • date: 2019
    • words: 8485
    • flesch: 42
    • summary: Diese aktivierten T-Zellen bilden einen großen Anteil der typischen Pfeiffer-Zellen (syn. lymphatische Reizformen, Virozyten) und der teilweise extremen Lymphozytose im In der Mehrzahl der Fälle kommt es hierbei zu einer unterschiedlich ausgeprägten, meist isotonen, selten einer hypertonen Dehydratation.
    • keywords: abb; aciclovir; akuten; aller; als; andere; anschließend; ansonsten; antikörper; assoziierten; auch; auf; auftreten; aus; ausbruch; außerdem; b19; beginnt; behandelt; behandlung; bei; bei der; bei einer; bei kindern; beim; bereich; bereits; besteht; bestimmung; beträgt; bevölkerung; bilden; bis; bis zu; bisher; blut; bläschen; bzw; chronischer; cmv; dagegen; dann; das; dem; der; derzeit; des; diagnose; diagnostik; die; diese; durch; dürfen; ebv; effloreszenzen; eine; elisa; entlang; enzephalitis; epidemiologie; erfolgen; erfolgt; erforderlich; erkrankung; erreger; ersten; erwachsenen; es zu; etwa; exanthem; existieren; faktoren; familie; fetalen; fetalis; fieber; findet; folge; folgenden; fsme; fällen; führen; führt; für; gabe; geburt; gehen; gehören; gehört; geimpft; genitalis; gestellt; gleichzeitig; granulozyten; gruppe; haut; hav; hcv; hepatitis; herpes; herpesenzephalitis; herpesviren; hhv-6; hierbei; hierdurch; hinsichtlich; hiv; hohem; hsv; hsv-1; humane; husten; hydrops; häufig; häufigkeit; igg; igm; immer; immunität; immunkompetenten; immunsuppression; immunsupprimierten; impfung; infektion; infektiösen; infizierten; influenza; inkubationszeit; innerhalb; insgesamt; ist; ist der; jahre; jederzeit; jungen; kann; kann bei; kindern; kindesalter; kleinen; klinik; klinischen; kommen; kommt; kommt es; komplikationen; konnatale; kopfschmerzen; krankheitsbild; können; körperflüssigkeiten; labialis; labor; lassen; lebensjahr; lebenslang; leber; leicht; letalität; liegt; liquor; lymphknoten; lymphomen; lymphoproliferativen; lymphozyten; lymphozytose; masern; masernenzephalitis; meist; meisten; meldepflichtig; mit; mit der; mit einer; mittels; monaten; muss; muttermilch; möglicherweise; nach; nach einer; nachgewiesen; nachweis; nerven; neue; neugeborenen; neurologischen; nicht; noch; nur; oberen; oder; ohne; organtransplantation; parainfluenzaviren; parvovirus; patienten; pcr; peripheren; persistiert; personen; pleozytose; pneumonie; polymerasekettenreaktion; positive; primärinfektion; prognose; prophylaxe; rahmen; reaktiviert; reaktivierung; regel; rhinoviren; rna; rolle; rsv; scheint; schwangerschaft; schweren; sehr; sein; selten; seltener; sensorischen; serum; sich; sie; simplex; sind; sog; sollte; sowie; speichel; spezifische; spielt; später; steht; subitum; symptomatik; symptomatische; symptome; tage; teilweise; therapie; treten; tritt; typischen; ubiquitär; und; unspezifischen; unter; ursache; varizellen; verfügung; verhindern; verlaufen; verschiedene; virus; viruslast; virusvermehrung; virämie; vom; von; vor; vzv; wahrscheinlich; wandert; warzen; weitere; wenn; werden; wieder; wird; wochen; während; zeigen; zeigt; zellen; zellulären; zns; zoster; zu den; zu einer; zum; zur; zwischen; zytomegalie; älteren; ätiopathogenese; über; übertragen; überwiegend
    • versions: original; plain text
58. cord-103297-4stnx8dw
    • author: Widrich, Michael
    • title: Modern Hopfield Networks and Attention for Immune Repertoire Classification
    • date: 2020-08-17
    • words: 14116
    • flesch: 51
    • summary: A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding Predicting the sequence specificities of DNA-and RNA-binding proteins by deep learning Explaining and interpreting LSTMs Solving the protein sequence metric problem Rank-loss support instance machines for miml instance annotation Augmenting adaptive immunity: progress and challenges in the quantitative engineering and analysis of adaptive immune receptor repertoires Multiple instance learning: a survey of problem characteristics and applications VDJServer: a cloud-based analysis portal and data commons for immune repertoire sequences and rearrangements Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge iReceptor: a platform for querying and analyzing antibody/B-cell and T-cell receptor repertoire data across federated repositories Support-vector networks Quantifiable predictive features define epitope-specific T cell receptor repertoires On a model of associative memory with huge storage capacity BERT: pre-training of deep bidirectional transformers for language understanding Solving the multiple instance problem with axis-parallel rectangles Predicting the spectrum of TCR repertoire sharing with a data-driven model of recombination Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire Predicting antigen-specificity of single T-cells based on TCR CDR3 regions. We apply random and attention-based subsampling of repertoire sequences to reduce over-fitting and decrease computational effort.
    • keywords: aas; analysis; antigen; approach; attention; auc; average; bag; batch; burden; category; cell; characters; classification; cmv; cnn; computational; contribution; cross; data; datasets; deeprc; details; different; embedding; emerson; end; et al; features; folds; following; frequency; function; grid; high; hopfield; hyperparameter; immune; immune repertoire; immunosequencing; individual; input; instances; kernel; label; large; layer; learning; length; logistic; lstm; machine; max; mechanism; memory; methods; mil; minmax; model; modern; motif; multiple; negative; networks; neural; number; object; patterns; performance; point; pooling; position; positive; predictive; probability; problem; queries; random; range; rate; real; receptor; repertoire; repertoire classification; representation; results; rule; score; search; section; sequences; settings; signal; simulated; single; size; specific; standard; status; sub; svm; table; tcr; test; training; transformer; update; validation; values; vector; weight; witness; world
    • versions: original; plain text
59. cord-193356-hqbstgg7
    • author: None
    • title: cord-193356-hqbstgg7
    • date: None
    • words: 14115
    • flesch: 51
    • summary: A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding Predicting the sequence specificities of DNA-and RNA-binding proteins by deep learning Explaining and interpreting LSTMs Solving the protein sequence metric problem Rank-loss support instance machines for miml instance annotation Augmenting adaptive immunity: progress and challenges in the quantitative engineering and analysis of adaptive immune receptor repertoires Multiple instance learning: a survey of problem characteristics and applications VDJServer: a cloud-based analysis portal and data commons for immune repertoire sequences and rearrangements Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge iReceptor: a platform for querying and analyzing antibody/B-cell and T-cell receptor repertoire data across federated repositories Support-vector networks Quantifiable predictive features define epitope-specific T cell receptor repertoires On a model of associative memory with huge storage capacity BERT: pre-training of deep bidirectional transformers for language understanding Solving the multiple instance problem with axis-parallel rectangles Predicting the spectrum of TCR repertoire sharing with a data-driven model of recombination Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire Predicting antigen-specificity of single T-cells based on TCR CDR3 regions. We apply random and attention-based subsampling of repertoire sequences to reduce over-fitting and decrease computational effort.
    • keywords: aas; analysis; antigen; approach; attention; auc; average; bag; batch; burden; category; cell; characters; classification; cmv; cnn; computational; contribution; cross; data; datasets; deeprc; details; different; embedding; emerson; end; et al; features; folds; following; frequency; function; grid; high; hopfield; hyperparameter; immune; immune repertoire; immunosequencing; individual; input; instances; kernel; label; large; layer; learning; length; logistic; lstm; machine; max; mechanism; memory; methods; mil; minmax; model; modern; motif; multiple; negative; networks; neural; number; object; patterns; performance; point; pooling; position; positive; predictive; probability; problem; queries; random; range; rate; real; receptor; repertoire; repertoire classification; representation; results; rule; score; search; section; sequences; settings; signal; simulated; single; size; specific; standard; status; sub; svm; table; tcr; test; training; transformer; update; validation; values; vector; weight; witness; world
    • versions: original; plain text
60. cord-257114-pxmflm2c
    • author: BURGUETE, SERGIO R.
    • title: Lung transplant infection
    • date: 2012-12-26
    • words: 11402
    • flesch: 31
    • summary: Invasive lung infection with Candida is very infrequent even in the LT recipient colonized with Candida. The incidence of CMV infection has been reported to range from 30% to 86% in post-LTR, with a mortality of 2-12%.
    • keywords: activation; acute; agents; airway; allograft; amphotericin; antifungal; aspergillosis; aspergillus; associated; bacterial; basiliximab; bos; bronchial; bronchiolitis; burkholderia; candida; care; cases; cause; cell; centres; chronic; clinical; cmv; colonization; colonized; combination; common; community; complications; culture; cystic; cytomegalovirus; data; days; development; diagnosis; disease; donor; early; effects; factors; fibrosis; fungal; general; gram; group; guidelines; heart; high; human; immunosuppression; impact; important; incidence; increase; induction; infection; influenza; inhaled; international; invasive; late; life; lower; ltr; lung; lung transplantation; lymphocytes; majority; management; months; morbidity; mortality; mycophenolate; negative; obliterans; organ; organ transplant; organisms; outcomes; pathogens; patients; period; pneumonia; positive; post; present; pretransplant; prevention; prophylaxis; pulmonary; recent; recipients; reduction; regimen; rejection; resistance; respiratory; results; review; ribavirin; risk; role; rsv; screening; severe; significant; society; solid; solid organ; species; studies; study; survival; syndrome; therapy; transplant; transplant patients; transplant recipients; transplantation; treatment; use; valganciclovir; viral; virus; voriconazole; year
    • versions: original; plain text
61. cord-259194-9zllvfqb
    • author: Cupples, Sandra A.
    • title: Transplant Infectious Disease: Implications for Critical Care Nurses
    • date: 2011-11-02
    • words: 4470
    • flesch: 33
    • summary: It is important to note that treatment of donor infections itself can further increase the potential donor's risk of iatrogenic infection, for example, via the insertion of intravascular catheters for antimicrobial therapy, the administration of immunomodulating medications such as corticosteroids, and prolonged hospitalization. Thus, liver transplant recipients with CMV infections are prone to develop vanishing bile duct syndrome, heart transplants recipients are at risk for coronary artery vasculopathy, lung transplant recipients are at risk for bronchiolitis obliterans, and so forth.
    • keywords: agents; allograft; antibiotics; antimicrobial; assist; associated; bacterial; blood; candidates; care; catheters; cause; center; clinical; cmv; cns; common; critical; device; disease; donor; driveline; ebv; exposure; factors; fungal; fungi; gram; heart; hepatitis; highest; immune; immunosuppression; important; infections; kidney; left; liver; lung; major; manifestations; mechanical; mediastinitis; mortality; negative; nurses; organ; organisms; pancreas; pathogens; patient; pneumonia; posttransplant; potential; prolonged; pump; recipients; rejection; risk; setting; solid; spp; support; surgical; tests; therapy; transmission; transplant; transplant recipients; transplantation; treatment; vad; vads; ventricular; viral; virus; viruses
    • versions: original; plain text
62. cord-263276-keyu60in
    • author: Zhou, Weimin
    • title: Prevalence of Herpes and Respiratory Viruses in Induced Sputum among Hospitalized Children with Non Typical Bacterial Community-Acquired Pneumonia
    • date: 2013-11-18
    • words: 3815
    • flesch: 48
    • summary: Global burden of disease in 2002: data sources, methods and results Community-acquired pneumonia in children Etiology of community-acquired pneumonia in 254 hospitalized children Etiology of community-acquired pneumonia in hospitalized children based on WHO clinical guidelines Access to a polymerase chain reaction assay method targeting 13 respiratory viruses can reduce antibiotics: a randomised, controlled trial Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children The role of respiratory viral infections among children hospitalized for community-acquired pneumonia in a developing country Comprehensive detection of causative pathogens using real-time PCR to diagnose pediatric community-acquired pneumonia Etiology and epidemiology of viral pneumonia among hospitalized children in rural Mozambique: a malaria endemic area with high prevalence of human immunodeficiency virus Viral etiology of severe pneumonia among Kenyan infants and children Etiology of community-acquired pneumonia in hospitalized school-age children: evidence for high prevalence of viral infections Improved diagnosis of the etiology of community-acquired pneumonia with real-time polymerase chain reaction Induced sputum in the diagnosis of childhood community-acquired pneumonia Viruses and bacteria in sputum samples of children with community-acquired pneumonia Lower respiratory infections among hospitalized children in New Caledonia: a pilot study for the Pneumonia Etiology Research for Child Health project The burden of respiratory syncytial virus infection in young children Rhinovirus transmission within families with children: incidence of symptomatic and asymptomatic infections Combined cytomegalovirus prophylaxis in lung transplantation: effects on acute rejection, lymphocytic bronchitis/bronchiolitis, and herpesvirus infections Cytomegalovirus infection in critically ill patients: associated factors and consequences Herpesviruses detection by quantitative real-time polymerase chain reaction in bronchoalveolar lavage and transbronchial biopsy in lung transplant: viral infections and histopathological correlation Three new human herpesviruses (HHV6, 7, and 8) Human bocavirus infections in hospitalized children and adults Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand Update on rhinovirus and coronavirus infections Rapid and simultaneous detection of 6 types of human herpes virus (herpes simplex virus, varicella-zoster virus, Epstein-Barr virus, cytomegalovirus, human herpes virus 6A/B, and human herpes virus 7) by multiplex PCR assay Etiology and clinical characterization of respiratory virus infections in adult patients attending an emergency department in Beijing Molecular assays for detection of human metapneumovirus Epidemiological profile and clinical associations of human bocavirus and other human parvoviruses Characterization of human coronavirus etiology in Chinese adults with acute upper respiratory tract infection by real-time RT-PCR assays The role of viruses in the aetiology of community-acquired pneumonia in adults Lower respiratory tract viral infections in hospitalized adult patients Molecular monitoring of causative viruses in child acute respiratory infection in endemoepidemic situations in Shanghai Effects of coronavirus infections in children Mixed respiratory virus infections Multipathogen infections in hospitalized children with acute respiratory infections Viruses in community-acquired pneumonia in children aged less than 3 years old: high rate of viral coinfection Severe respiratory syncytial virus pneumonia associated with primary Epstein-Barr virus infection Cytomegalovirus and herpes simplex virus effect on the prognosis of mechanically ventilated patients suspected to have ventilator-associated pneumonia Cytomegalovirus pneumonia in immunocompetent host: case report and literature review CMV in critically ill patients: pathogen or bystander We thank the medical and technical staffs from the Wenling Hospital for their assistance and support. In this study, it was unable to determine whether the HHVs were reactivated from a latent reservoir after another respiratory virus infection, or if an immunosuppressed condition caused by HHV infection increases the potential risk of other respiratory virus infections.
    • keywords: addition; adv; age; agents; area; bacterial; cap; cases; children; china; clinical; cmv; community; control; data; detection; ebv; etiology; group; hbov; herpes; hhv-6; hhvs; higher; hospitalised; human; infants; infections; non; patients; pcr; pneumonia; prevalence; previous; rate; respiratory; rhinovirus; rsv; rural; samples; sputum; studies; study; typical; viral; viruses; young
    • versions: original; plain text
63. cord-266218-r6xg9zts
    • author: Law, Arjun Datt
    • title: Reduced-Intensity Conditioning and Dual T Lymphocyte Suppression with Antithymocyte Globulin and Post-Transplant Cyclophosphamide as Graft-versus-Host Disease Prophylaxis in Haploidentical Hematopoietic Stem Cell Transplants for Hematological Malignancies
    • date: 2018-08-07
    • words: 4374
    • flesch: 43
    • summary: Reduced-intensity conditioning with fludarabine, reduceddose busulfan, and TBI (200 cGy) is a low-toxicity regimen that induces sufficient immunosuppression to permit donor hematopoietic cells to consistently engraft despite the HLAhaplotype barrier. Donor memory T cells are relatively protected from PTCy and provide donor immunity in addition to immune reconstitution post-transplant [13] .
    • keywords: acute; allogeneic; atg; blood; busulfan; cases; cell; chronic; cmv; complications; conditioning; cyclophosphamide; cyclosporine; days; disease; donor; dose; ebv; engraftment; fludarabine; follow; globulin; grade; graft; gvhd; haplohsct; haploidentical; hematopoietic; high; hla; host; incidence; intensity; low; lymphoproliferative; marrow; median; months; mud; nrm; outcomes; patients; pbsc; post; prophylaxis; ptcy; ptld; range; rates; reactivation; regimen; relapse; related; ric; risk; severe; stem; therapy; time; total; transplantation; transplants; unrelated; use
    • versions: original; plain text
64. cord-267269-05mezubh
    • author: Plazolles, N.
    • title: Pivotal Advance: The promotion of soluble DC‐SIGN release by inflammatory signals and its enhancement of cytomegalovirus‐mediated cis‐infection of myeloid dendritic cells
    • date: 2010-10-12
    • words: 8854
    • flesch: 47
    • summary: The study in question shed new light on the molecular interactions that favor DC infection by CMV and especially the pivotal role played by DC-SIGN as a docking and internalizing receptor. Inter-individual variation in expression of DC-SIGN transcripts Most DC-SIGNR transcripts at mucosal HIV transmission sites are alternatively spliced isoforms DC-SIGN, but not sDC-SIGN, can modulate IL-2 production from PMAand anti-CD3-stimulated primary human CD4 T cells Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection Human cytomegalovirus labeled with green fluorescent protein for live analysis of intracellular particle movements Human cytomegalovirus impairs dendritic cell function: a novel mechanism of human cytomegalovirus immune escape Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor ␣ B lymphocytes secrete antigenpresenting vesicles Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120 Determinants in the N-terminal domains of galectin-3 for secretion by a novel pathway circumventing the endoplasmic reticulum-Golgi complex A novel secretory pathway for interleukin-1 ␤, a protein lacking a signal sequence Unconventional secretion of fibroblast growth factor 2 and galectin-1 does not require shedding of plasma membrane-derived vesicles Regulation of expression and secretion of galectin-3 in human monocyte-derived dendritic cells CD34ϩ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSFϩTNF ␣ The structure of DC-SIGNR with a portion of its repeat domain lends insights to modeling of the receptor tetramer Structural requirements for multimerization of the pathogen receptor dendritic cell-specific ICAM3-grabbing non-integrin (CD209) on the cell surface Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN DC-SIGN association with the Th2 environment of lepromatous lesions: cause or effect?
    • keywords: able; addition; aldrich; amounts; analysis; anti; antibody; bal; binding; biotechnology; blood; blot; cdna; cells; clone; cmv; cmv infection; concentrated; concentrations; conditions; control; csf; culture; cxcl-8; data; days; dcs; dendritic; dependent; detection; differentiation; domain; effect; elisa; encoding; exosome; experiments; explants; expression; fig; filtration; flag; fluids; france; functional; gel; high; hiv; human; ifn-; il-4; il-8; immature; increase; infected; infection; inflammatory; internalization; isoforms; isolated; joint; lectin; like; low; mab; macrophages; manner; mdc; medium; membrane; min; modc; monocyte; mucosa; native; patients; pcr; presence; previous; protein; receptor; recombinant; regulation; release; results; role; rsdc; samples; sdc; sdc‐sign; secretion; sequence; sera; serum; sigma; sign; sign expression; sign1at1; signal; significant; soluble; specific; study; supernatants; supplemented; tetramers; tissue; type; unable; usa; variants; viral; vitro; western
    • versions: original; plain text
65. cord-269194-b1wlr3t7
    • author: Engstrom-Melnyk, Julia
    • title: Chapter 5 Clinical Applications of Quantitative Real-Time PCR in Virology
    • date: 2015-12-31
    • words: 12555
    • flesch: 22
    • summary: Determining a patient's HIV viral load is indicated prior to entry into care, at the initiation of ART, at 2-8 weeks after ART initiation, and then typically every 3-4 months while on treatment: (1) to establish a baseline level of HIV viral load; (2) to establish viral response to the therapy to assess the virologic efficacy of ART; and (3) to monitor for abnormalities that may be associated with antiretroviral drugs (DHHS HIV, 2014) . (A) HIV viral loads will fluctuate as patients are on treatment, and, in most instances, will remain 'undetectable' (at or below dotted line); viral 'blips' are not uncommon and will result in transient 'detectable' and even quantifiable results (above the dashed line).
    • keywords: aasld; accurate; acid; acute; aids; amplification; antibody; antiretroviral; antiviral; applications; appropriate; art; assays; assessment; baseline; care; cdc; cell; chronic; clinical; clinicians; cmv; competitive; concentration; control; copies; critical; culture; cure; cytomegalovirus; decision; detectable; detection; developed; development; diagnosis; disease; dna; donor; drug; duration; early; ebola; effective; efficacy; emptive; epidemic; et al; factors; failure; fda; greater; guidelines; hbv; hcv; hcv treatment; health; hepatitis; high; higher; hiv; hiv viral; hiv-1; human; identification; idsa; immunodeficiency; increase; infected; infection; influenza; information; initial; initiation; international; introduction; laboratories; laboratory; ldts; levels; limits; liver; lloq; load; lod; long; lower; management; methods; molecular; monitoring; nat; nats; need; new; nucleic; order; organ; outcomes; patients; pcr; pcr assays; point; polymerase; positive; post; potential; practice; pre; prevention; prior; progression; quantitative; quantitative pcr; quantitative real; range; rapid; reaction; real; recipients; recommendations; regimen; reporting; resistance; response; results; risk; rna; role; sample; screening; sensitive; sensitivity; significant; solid; specific; standard; studies; suppression; svr; target; technology; testing; tests; therapeutic; therapy; time; time pcr; time quantitative; transplant; transplantation; treatment; use; value; viral; viral infections; viral levels; viral load; virologic; virology; virus; viruses; weeks
    • versions: original; plain text
66. cord-272835-6nx4f8ss
    • author: Paulsen, Grant C.
    • title: Respiratory Viral Infections in Solid Organ and Hematopoietic Stem Cell Transplantation
    • date: 2017-12-31
    • words: 10260
    • flesch: 24
    • summary: Assessment of adenovirus infection in adult lung transplant recipients using molecular surveillance Adenovirus infection in pediatric small bowel transplantation recipients Clinical characteristics and outcomes of adenovirus infection of the urinary tract after renal transplantation Association of viral genome with graft loss in children after cardiac transplantation Treatment of adenovirus pneumonia with cidofovir in pediatric lung transplant recipients Monitoring of adenovirus (ADV)-specific T cells in a boy with ADV pneumonia and disseminated disease after lung transplantation Adenovirus infection in the lung results in graft failure after lung transplantation Adenovirus pneumonia in lung transplant recipients Poor outcome of adenovirus infections in adult hematopoietic stem cell transplant patients with sustained adenovirus viremia Occurrence, risk factors and outcome of adenovirus infection in adult recipients of allogeneic hematopoietic stem cell transplantation Disseminated adenovirus infections after allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcome Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation Treatment of adenovirus disease in stem cell transplant recipients with cidofovir Intravenous ribavirin treatment for severe adenovirus disease in immunocompromised children Brincidofovir for asymptomatic adenovirus viremia in pediatric and adult allogeneic hematopoietic cell transplant recipients: a randomized placebocontrolled phase II trial Safety and efficacy of CMX001 as salvage therapy for severe adenovirus infections in immunocompromised patients Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation Adoptive T-cell therapy with hexon-specific Th1 cells as a treatment of refractory adenovirus infection after HSCT Cellular immunotherapy for viral infection after HSC transplantation Parainfluenza and influenza virus infections in pediatric organ transplant recipients Parainfluenza 3 infections early after kidney or simultaneous pancreas-kidney transplantation Parainfluenza virus infections after hematopoietic stem cell transplantation: risk factors, response to antiviral therapy, and effect on transplant outcome Parainfluenza virus respiratory infection after bone marrow transplantation Human parainfluenza virus infection after hematopoietic stem cell transplantation: risk factors, management, mortality, and changes over time Timing and severity of community acquired respiratory virus infections after myeloablative versus nonmyeloablative hematopoietic stem cell transplantation The characteristics and outcomes of parainfluenza virus infections in 200 patients with leukemia or recipients of hematopoietic stem cell transplantation Parainfluenza virus lower respiratory tract disease after hematopoietic cell transplant: viral detection in the lung predicts outcome Parainfluenza virus type 3 infections in hematopoetic stem cell transplant recipients: response to ribavirin therapy Parainfluenza virus 3 infection after stem cell transplant: relevance to outcome of rapid diagnosis and ribavirin treatment Parainfluenza virus 3 pneumonia in a kidney transplant recipient DAS181 treatment of severe parainfluenza type 3 pneumonia in a lung transplant recipient Clinical potential of DAS181 for treatment of parainfluenza-3 infections in transplant recipients Treatment of parainfluenza 3 infection with DAS181 in a patient after allogeneic stem cell transplantation DAS181 for treatment of parainfluenza virus infections in hematopoietic stem cell transplant recipients at a single center Cholesterol reducing agents inhibit assembly of type I parainfluenza viruses Human parainfluenza virus-3 can be targeted by rapidly ex vivo expanded T lymphocytes Human metapneumovirus in lung transplant recipients: characteristics and outcomes Human metapneumovirus infection in lung transplant recipients: clinical presentation and epidemiology The human metapneumovirus: a case series and review of the literature Human metapneumovirus infections in hematopoietic cell transplant recipients and hematologic malignancy patients: a systematic review Frequency of human metapneumovirus infection in hematopoietic SCT recipients during 3 consecutive years Mortality rates of human metapneumovirus and respiratory syncytial virus lower respiratory tract infections in hematopoietic cell transplantation recipients Human metapneumovirus infections following hematopoietic cell transplantation: factors associated with disease progression Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by ribavirin and immune serum globulin in vitro Singlecentre experience with oral ribavirin in lung transplant recipients with paramyxovirus infections Successful outcome of human metapneumovirus (hMPV) pneumonia in a lung transplant recipient treated with intravenous ribavirin Efficacy of oral ribavirin in hematologic disease patients with paramyxovirus infection: analytic strategy using propensity scores Adoptive T-cell therapy to prevent and treat human metapneumovirus (hMPV) infections post hematopoietic stem cell transplant (HSCT) Prophylactic and therapeutic benefits of a monoclonal antibody against the fusion protein of human metapneumovirus in a mouse model Frequent occult infection with cytomegalovirus in cardiac transplant recipients despite antiviral prophylaxis Fatal cytomegalovirus pneumonia in patients with haematological malignancies: an autopsy-based case-control study Cytomegalovirus disease is associated with higher all-cause mortality after lung transplantation despite extended antiviral prophylaxis Updated international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation Cytomegalovirus disease among donor-positive/recipientnegative lung transplant recipients in the era of valganciclovir prophylaxis Definitions of cytomegalovirus infection and disease in transplant patients for use in clinical trials Cytomegalovirus (CMV) DNA quantitation in bronchoalveolar lavage fluid from hematopoietic stem cell transplant recipients with CMV pneumonia Incidence, risk factors and outcomes of delayedonset cytomegalovirus disease in a large retrospective cohort of lung transplant recipients Airway complications after lung transplantation: contemporary survival and outcomes Lower incidence of CMV infection and acute rejections with valganciclovir prophylaxis in lung transplant recipients Reduced mortality of cytomegalovirus pneumonia after hematopoietic cell transplantation due to antiviral therapy and changes in transplantation practices Cytomegalovirus pneumonia in adult autologous blood and marrow transplant recipients Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis Use of cytomegalovirus intravenous immune globulin for the adjunctive treatment of cytomegalovirus in hematopoietic stem cell transplant recipients High incidence of ganciclovir-resistant cytomegalovirus infection among lung transplant recipients receiving preemptive therapy Cytomegalovirus disease and infection in lung transplant recipients in the setting of planned indefinite valganciclovir prophylaxis Cytomegalovirus immunoglobulin for prophylaxis and treatment of cytomegalovirus infection in the (Val)ganciclovir era: a single-center experience Cytomegalovirus diseases after hematopoietic stem cell transplantation: a mini-review Cytomegalovirus in hematopoietic stem cell transplant recipients Everolimus versus mycophenolate mofetil de novo after lung transplantation: a prospective, randomized, openlabel trial Everolimusbased immunosuppressive regimens in lung transplant recipients: impact on CMV infection Lower incidence of cytomegalovirus infection with everolimus versus mycophenolate mofetil in de novo cardiac transplant recipients: a randomized, multicenter study Everolimus is associated with a reduced incidence of cytomegalovirus infection following de novo cardiac transplantation Everolimus versus azathioprine in maintenance lung transplant recipients: an international, randomized, doubleblind clinical trial Recommendations on the use of everolimus in lung transplantation Management of cytomegalovirus infection in solid organ transplant recipients: SET/GESITRA-SEIMC/ REIPI recommendations Cytomegalovirus vaccines under clinical development Safety of ASP0113, a cytomegalovirus DNA vaccine, in recipients undergoing allogeneic hematopoietic cell transplantation: an open-label phase 2 trial Viraemia, immunogenicity, and survival outcomes of cytomegalovirus chimeric epitope vaccine supplemented with PF03512676 (CMVPepVax) in allogeneic haemopoietic stem-cell transplantation: randomised phase 1b trial Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial Oral valganciclovir is noninferior to intravenous ganciclovir for the treatment of cytomegalovirus disease in solid organ transplant recipients CMV immunoglobulins for the treatment of CMV infections in thoracic transplant recipients Letermovir for cytomegalovirus prophylaxis in hematopoietic-cell transplantation Preemptive treatment of cytomegalovirus infection in kidney transplant recipients with letermovir: results of a phase 2a study Maribavir prophylaxis for prevention of cytomegalovirus disease in recipients of allogeneic stem-cell transplants: a phase 3, double-blind, placebo-controlled, randomised trial Efficacy and safety of maribavir dosed at 100 mg orally twice daily for the prevention of cytomegalovirus disease in liver transplant recipients: a randomized, double-blind, multicenter controlled trial CMX001 to prevent cytomegalovirus disease in hematopoieticcell transplantation Adoptive T-cell therapy of a lung transplanted patient with severe CMV disease and resistance to antiviral therapy Transfer of minimally manipulated CMV-specific T cells from stem cell or third-party donors to treat CMV infection after allo-HSCT Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation Herpes simplex virus infection in heart-lung transplant recipients Herpes simplex virus (HSV) pneumonia in a heart transplant: diagnosis and therapy Acyclovirresistant herpes simplex virus pneumonia postunrelated stem cell transplantation: a word of caution Herpes simplex virus in solid organ transplantation Varicella zoster virus in solid organ transplantation Varicella-zoster virus: pathogenesis, immunity, and clinical management in hematopoietic cell transplant recipients Pneumonia due to varicella-zoster virus reinfection in a renal transplant recipient RNA respiratory viruses in solid organ transplantation Outcomes from pandemic influenza A H1N1 infection in recipients of solid-organ transplants: a multicentre cohort study The impact of pandemic influenza A H1N1 2009 on Australian lung transplant recipients Clinical characteristics and outcomes of influenza A infection in kidney transplant recipients: a singlecenter experience Differences in clinical outcomes after 2009 influenza A/H1N1 and seasonal influenza among hematopoietic cell transplant recipients Outcomes of influenza infections in hematopoietic cell transplant recipients: application of an immunodeficiency scoring index Influenza vaccination in the organ transplant recipient: review and summary recommendations Immunogenicity, reactogenicity and safety of an inactivated quadrivalent influenza vaccine candidate versus inactivated trivalent influenza vaccine: a phase III, randomized trial in adults aged !
    • keywords: activity; acute; addition; adenovirus; adoptive; adult; age; allogeneic; antiviral; asymptomatic; attributable; available; care; cause; cell; cell transplant; cell transplantation; children; cidofovir; clinical; cmv; common; cytomegalovirus; das181; days; disease; dna; dose; early; effective; efficacy; factors; gcv; h1n1; hematopoietic; high; hmpv; hsct; hsct patients; hsct recipients; human; immunocompromised; inactivated; incidence; infection; influenza; inhaled; intravenous; ivig; limited; lower; lrti; lung; lung transplant; metapneumovirus; months; morbidity; mortality; oral; organ; oseltamivir; outcomes; palivizumab; pandemic; parainfluenza; patients; pediatric; phase; piv; pneumonia; population; positive; prevention; progression; prophylaxis; randomized; recent; recipients; recommendations; rejection; renal; reported; reports; resistant; respiratory; response; results; retrospective; ribavirin; risk; rsv; rvi; rvis; severe; significant; solid; sot; specific; stem; stem cell; study; syncytial; therapy; time; transplant; transplant patients; transplant recipients; transplantation; treatment; trial; urti; use; vaccination; vaccine; viral; virus; viruses; years; zanamivir
    • versions: original; plain text
67. cord-274012-56i4sikj
    • author: Gavaldà, Joan
    • title: Infección en el trasplante de pulmón
    • date: 2007-11-30
    • words: 9589
    • flesch: 45
    • summary: El diagnóstico de la infección y de la enfermedad por CMV está establecido internacionalmente a partir de un artículo de Ljungman, Griffiths y Paya 42 y, posteriormente, a partir de un documento de consenso del Grupo de Estudio de la Infección en el Trasplante de la SEIMC 43 . En este capítulo nos centraremos en la epidemiología, la clínica, el diagnóstico, el tratamiento y la prevención de las infecciones bacterianas, víricas y fúngicas de los receptores de un trasplante de pulmón.
    • keywords: además; aeruginosa; algunos; alrededor; anfotericina; antes; anticipado; antigenemia; aspergillus; aspergilosis; aunque; aureus; año; bacteriana; bronquiectasias; bronquiolitis; cada; candida; casos; causa; cerca; chronic; cifra; clínica; cmv; colonización; como; complicaciones; complicación; con; con el; con la; crónico; cuando; cultivos; cytomegalovirus; de infección; de la; de los; de pacientes; de pulmón; de un; del; demostrado; desarrollo; descartar; después; después de; diagnóstico; diferentes; donante; dos; dosis; drenaje; duración; durante; días; el pulmón; el riesgo; el tratamiento; elevada; ellos; en el; en los; enfermedad; enfermedad por; entre; episodios; es la; es un; esta; estado; este; estos; estrategias; estudio; está; etiología; evidencia; existen; factores; fibrosis; final; forma; frecuente; frecuente de; fue; fueron; función; fúngica; gammaglobulina; ganciclovir; general; grave; grupo; han; hasta; hay; heart; impact; importante; incidencia; incidencia de; infecciones; infección; infección por; infection; inicial; inicio; injerto; inmunosupresión; insuficiencia; international; invasora; itraconazol; la enfermedad; la incidencia; la infección; la profilaxis; largo; las; liposomal; los; los pacientes; los receptores; lung; lung transplantation; mayor; mayoría; menor; meses; microorganismos; mortalidad; muerte; muy; más; más frecuente; médica; nebulizada; neumonitis; neumonía; nuestro; número; obliterante; ocasiones; oral; otros; pacientes; para; para el; para la; patients; pero; período; pesar; plazo; por; por cmv; por la; posible; posteriormente; postrasplante; presentar; prevención; primeros; probablemente; profilaxis; prophylaxis; puede; pulmón; que; que el; que la; quística; realizar; receptores; receptores de; rechazo; recientemente; recipients; rejection; relacionada; relación; respiratoria; respuesta; resto; resultados; riesgo; risk; sea; secreciones; segundo; semana; ser; series; seronegativos; seropositivo; siempre; signos; simple; sin; society; son; spp; supervivencia; sutura; séptica; sólido; también; tiene; tipo; tipo de; todos; total; transplantation; traqueobronquitis; trasplantados; trasplante; trasplante de; tratados; tratamiento; tres; tuberculosis; ulcerativa; un trasplante; una; utilización; utilizar; valganciclovir; veb; viral; virus; voriconazol; y el; y en; y la; y se; órgano; única
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68. cord-276343-sb3vd7fq
    • author: Humar, Atul
    • title: Assessment of Adenovirus Infection in Adult Lung Transplant Recipients Using Molecular Surveillance
    • date: 2006-12-31
    • words: 3532
    • flesch: 41
    • summary: Therefore, transplant patients may be at risk of adenovirus infection either from new acquisition or from re-activation of latent virus. sb3vd7fq Background Little is known about adenovirus infections in adult lung transplant recipients.
    • keywords: activation; acute; adenovirus; adult; allograft; cases; clinical; cmv; common; copies; data; detection; disease; dna; evidence; function; heart; infection; load; lung; months; patients; pcr; pediatric; plasma; pneumonitis; post; prophylaxis; pulmonary; range; recipients; rejection; respiratory; samples; study; surveillance; symptoms; testing; time; transplant; transplantation; viral; viremia; year
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69. cord-279638-jr1mbh7s
    • author: Calore, Elisabetta
    • title: Treatment of Acute Graft-versus-Host Disease in Childhood with Extracorporeal Photochemotherapy/Photopheresis: The Padova Experience
    • date: 2015-07-14
    • words: 5605
    • flesch: 51
    • summary: In conclusion, a standardized approach to ECP treatment is needed for pediatric patients. Eligibility criteria for ECP treatment were as follows: children with SR aGVHD (n ¼ 21); children with SD aGVHD (n ¼ 21); patients with aGVHD in whom IS therapy was contraindicated or who required a rapid decrease of IS therapy for increasing EBV viral load, CMV reactivation in 2 subsequent samples, systemic fungal infections, intolerable side effects (n ¼ 30).
    • keywords: acute; adv; agvhd; bkv; blood; bone; cell; children; chronic; clinical; cmv; date; day; days; difference; disease; dna; ebv; ecp; effects; experience; extracorporeal; follow; grade; graft; group; host; host disease; hsct; iii; italian; line; marrow; median; months; outcome; overall; patients; pediatric; photochemotherapy; photopheresis; primary; procedure; range; rate; reactivations; responders; response; second; stem; steroid; study; survival; therapy; transplantation; treatment; trm; viral; year
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70. cord-280374-yj0r4rwt
    • author: Jain, Richa
    • title: Hepatic sinusoidal-obstruction syndrome and busulfan-induced lung injury in a post-autologous stem cell transplant recipient
    • date: 2018-01-04
    • words: 2848
    • flesch: 38
    • summary: Marked atypia of the type II pneumocytes is a morphological clue in favour of busulfan induced lung injury in contrast to organizing bacterial pneumonia. The second pathology in this child which significantly contributed to his downhill course was busulfan induced lung injury.
    • keywords: absence; acute; bone; busulfan; candida; case; cell; child; clinical; cmv; common; day; diagnosis; disease; drug; early; features; fig; findings; fungal; hepatic; incidence; index; infections; infective; injury; ips; levels; liver; lung; marrow; neuroblastoma; normal; obstruction; occlusive; patients; pcj; pediatric; phase; pneumonia; post; presence; present; progressive; pulmonary; respiratory; right; sct; setting; sinusoidal; sos; stem; syndrome; transplantation; veno
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71. cord-282618-tjvjlyn9
    • author: Luke, J M
    • title: Improved antibiotic-free plasmid vector design by incorporation of transient expression enhancers
    • date: 2010-11-25
    • words: 6279
    • flesch: 35
    • summary: Electroporation for the delivery of DNA-based vaccines and immunotherapeutics: current clinical developments Improved antibiotic-free DNA vaccine vectors utilizing a novel RNA based plasmid selection system pDNAVACCultra vector family: high throughput intracellular targeting DNA vaccine plasmids Plasmid DNA vector design; impact on efficacy, safety and upstream production Generic plasmid DNA production platform incorporating low metabolic burden seed-stock and fed-batch fermentation processes Low metabolic burden plasmid production Plasmid DNA production combining antibiotic-free selection, inducible high yield fermentation, and novel autolytic purification Guidance for Industry: Considerations for Plasmid DNA Vaccines for Infectious Disease Indications Non-clinical Studies Required before First Clinical use of Gene Therapy Medicinal Products Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation Cryptic open reading frames in plasmid vector backbone sequences can provide highly immunogenic cytotoxic T-lymphocyte epitopes Translation from cryptic reading frames of DNA vaccines generates an extended repertoire of immunogenic, MHC class I-restricted epitopes Robust, vaccine-induced CD8+ T lymphocyte response against an out-of-frame epitope A similar mRNA translation efficiency increase was observed with plasmid vectors incorporating and expressing the protein kinase R-inhibiting adenoviral viral associated (VA)1 RNA.
    • keywords: a549; activation; activity; antibiotic; associated; backbone; binding; cell; cellular; cho; clinical; cmv; copy; cytoplasmic; delivery; design; dividing; dna; domain; downstream; effect; efficiency; egfp; electroporation; element; enhancement; enhancer; eukaryotic; expression; factor; figure; fluorescence; free; genome; genomic; gp120; gwiz; hek293; higher; htlv; human; iii; import; improved; increased; inhibition; integrated; integration; interference; kanr; levels; lines; localization; marker; mrna; nm23; non; ntc8685; nuclear; number; pcr; pkr; plasmid; pol; present; production; promoter; protein; rabbits; region; results; rna; rnai; sequences; sites; sp1; specific; supplementary; sv40; tee; therapy; total; transfection; transgene; transgene expression; transient; translation; type; upstream; usa; va1; vaccination; vaccine; vector; viral; virus
    • versions: original; plain text
72. cord-283826-lgyc3sro
    • author: Stiehm, E. Richard
    • title: Therapeutic Use of Immunoglobulins
    • date: 2010-11-05
    • words: 9757
    • flesch: 33
    • summary: A randomized double-blind trial Efficacy of intravenous immunoglobulin in the prevention of pneumonia in patients with common variable immunodeficiency High dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood Infusion of Fc gamma fragments for treatment of children with acute immune thrombocytopenic purpura Fcg receptor as regulators of immune responses Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc Identification of a receptor required for the anti-inflammatory activity of IVIG Mechanism of intravenous immune globulin therapy in antibody-mediated autoimmune diseases Accelerated autoantibody clearance by intravenous immunoglobulin therapy: Intravenous immune globulin for the prevention of bacterial infections in children with symptomatic human immunodeficiency virus infection Passive antibody therapies: progress and continuing challenges Antitoxin versus no antitoxin in scarlet fever Adjunctive treatment of streptococcal toxic shock syndrome using intravenous immunoglobulin: case report and review Different preparations of intravenous immunoglobulin vary in their efficacy to neutralize streptococcal superantigens: implications for treatment of streptococcal toxic shock syndrome Clinical usefulness of intravenous human immunoglobulins in invasive group
    • keywords: activity; acute; adhesion; administration; animal; anthrax; antibiotics; antibodies; antibody; antitoxin; autoimmune; available; bacterial; beneficial; benefit; blood; botulinum; botulism; box; category; cause; cells; certain; children; chronic; clinical; clostridium; cmv; cmvig; colleagues; committee; common; complement; complications; count; cytomegalovirus; diagnosis; difficile; diseases; disorders; donors; dose; early; effects; efficacy; encephalitis; equine; evidence; exposure; fever; frequency; health; hepatitis; high; human; humoral; hyperimmune; hypogammaglobulinemia; igg; igiv; iii; immune; immune globulin; immunodeficiency; immunoglobulin; increase; individuals; infants; infected; infection; inflammatory; infusion; intravenous; intravenous immunoglobulin; ivig; levels; liver; low; management; mechanisms; model; molecule; monoclonal; mortality; multiple; neonatal; normal; organ; parvovirus; patients; plasma; platelet; premature; preparations; prevention; primary; primary immunodeficiency; process; product; prophylaxis; purpura; quality; receptor; recurrent; replacement; report; respiratory; response; results; review; scig; sepsis; serum; severe; severity; shock; smallpox; specific; states; streptococcal; studies; study; subcutaneous; syndrome; table; tetanus; therapeutic; therapy; titers; toxic; transplantation; treatment; trial; trough; types; united; use; vaccine; value; variable; viral; virus
    • versions: original; plain text
73. cord-285433-ehnu83qe
    • author: Sun, Hongliu
    • title: Detection of Cytomegalovirus Antibodies Using a Biosensor Based on Imaging Ellipsometry
    • date: 2015-08-21
    • words: 4705
    • flesch: 50
    • summary: The key immune methods used for CMV antibody detection are: enzyme-linked immunosorbent assay (ELISA) Additionally, new immune methods for CMV antibody detection have been developed, such as the chemiluminesent microparticle immunoassay (CMIA)
    • keywords: analysis; antibodies; antibody; areas; bie; biosensor; blank; buffer; cell; clinical; cmv; cmv antibodies; cmv antibody; cmv-3a; columns; concentration; control; cytomegalovirus; detection; elisa; ellipsometry; fig; file; grayscale; grayscale value; high; human; igg; igm; imaging; infection; layer; ligand; mean; method; microfluidic; patient; pbst; protein; purified; quantitative; results; samples; second; sensitivity; serum; step; surface; table; value; wafers
    • versions: original; plain text
74. cord-288721-3bv3aak6
    • author: Schneider, Annika
    • title: Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection
    • date: 2019-06-11
    • words: 5607
    • flesch: 32
    • summary: Fig. 2 ) Taken together these data demonstrate that mitochondria which are in close physical proximity exchange information leading to changes in mitochondrial membrane potential but not in mitochondrial size. We chose the liver, and more specifically hepatocytes, as Viral infection increases size and mitochondrial fragility of liver mitochondria.
    • keywords: adenovirus; analysis; anti; antibodies; autofluorescence; bio; buffer; calcium; cells; cellular; changes; cmv; cytometry; decrease; density; dilc; dsred; dynamics; electron; expression; fig; flow; fluorescence; function; germany; glass; healthy; hepatitis; hepatocytes; ice; imaging; increase; infected; infection; influence; intensity; isolated; isolation; laboratories; level; livers; loss; mechanisms; membrane; metabolism; mice; microscopy; minutes; mitochondria; mitophagy; mitorl; non; organelle; potential; primary; protein; purified; rad; recombinant; results; scatter; scientific; single; size; supp; tbs; thermofisher; time; tissue; usa; viral; virus; viruses; vivo; www.nature.com/scientificreports/
    • versions: original; plain text
75. cord-288945-c9ow1q5c
    • author: Spengler, Ulrich
    • title: Liver Disease Associated with Non-Hepatitis Viruses
    • date: 2019-11-01
    • words: 7433
    • flesch: 31
    • summary: For certain regions simultaneous testing for dengue and Zika virus infection is recommended. Unusual manifestation of infection with Coxsackie virus group B, type 3 Reactivation of human herpesvirus 6 by infection of human herpesvirus 7 Chikungunya fever in travelers: Clinical presentation and course Pathology of fatal human infection associated with avian influenza A H5N1 virus Acyclovir for treatment of infectious mononucleosis: A metaanalysis Valacyclovir for herpes simples virus infection: Long-term safety and sustained efficacy after 20 years' experience with acyclovir Complete clinical and virological remission of refractory HIV-related Kaposi's sarcoma with pegylated interferon alpha Genetic divergence and dispersal of yellow fever virus A comparison of the pattern of liver involvement in dengue hemorrhagic fever with classic dengue fever Quantitation of Epstein-Barr virus mRNA using reverse transcription and real-time PCR Association of lymphomatoid granulomatosis with Epstein-Barr viral infection of B lymphocytes and response to interferon-alpha 2b Fever in returned travelers: Results from the GeoSentinel surveillance network Temporal pattern of hepatic dysfunction and disease severity in patients with SARS Dengue: Guidelines for diagnosis, treatment, prevention and control World Health Organization (2012) Handbook for clinical management of dengue Recovery from adenovirus pneumonia in a severe combined immunodeficiency patient with intravenous ribavirin Comparison of antiviral compounds against human herpesvirus 6 and 7 Human parvovirus B19 infection associated with acute hepatitis Acute exacerbation of autoimmune liver disease associated with hantaviral infection Human infection by avian influenza A H5N1 Disseminated herpes simplex type 2 and systemic Candida infection in a patient with previous asymptomatic HIV infection Histology slides were kindly provided by Prof. Dr. Hans-Peter Fischer, Department of Pathology, Rheinische Friedrich-Wilhelms University of Bonn, Germany.
    • keywords: acute; acyclovir; adenovirus; adults; africa; aminotransferases; antibodies; antiviral; assays; associated; asymptomatic; barr; blood; cases; castleman; cause; cell; certain; chikungunya; children; clinical; cmv; complications; coronavirus; cov; cytomegalovirus; damage; dengue; detection; diagnosis; disease; dna; ebv; elevated; epstein; et al; example; failure; fatal; features; fever; fig; fulminant; hanta; health; hemorrhagic; hepatic; hepatitis; herpesvirus; hhv-6; hhv8; high; hiv; hsv; human; illness; immune; immunocompetent; immunodeficiency; immunosuppression; individuals; infection; influenza; isolates; jaundice; kaposi; levels; limited; liver; liver disease; lymphocytes; lymphoma; lymphoproliferative; mononucleosis; multiple; necrosis; onset; organ; outbreaks; overview; pathology; patients; pcr; pneumonia; polymerase; positive; primary; rare; recipients; renal; resistant; respiratory; ribavirin; risk; sarcoma; sars; severe; simplex; solid; specific; study; symptoms; syndrome; therapy; time; transplantation; travelers; treatment; type; typical; vaccine; varicella; viral; virus; virus infection; viruses; world; yellow; zoster
    • versions: original; plain text
76. cord-290976-dhwlr2ui
    • author: Lednicky, John A
    • title: Isolation and genetic characterization of human coronavirus NL63 in primary human renal proximal tubular epithelial cells obtained from a commercial supplier, and confirmation of its replication in two different types of human primary kidney cells
    • date: 2013-06-27
    • words: 7817
    • flesch: 51
    • summary: Following 2-3 weeks of propagation without antibiotics, the plasmocin-treated cell lines and RPTEC cells were tested by PCR for the presence of mycoplasma DNA using a Takara PCR Mycoplasma Detection kit (Fisher Scientific, Pittsburgh, PA) The Art of animal cell culture for virus isolation Methods for detection and frequency of contamination of fetal calf serum with bovine viral diarrhea virus and antibodies against bovine viral diarrhea virus Bovine viral diarrhea disease associated with a contaminated vaccine Demonstration and genotyping of pestivirus RNA from mammalian cell lines Bovine viral diarrhea virus contamination of nutrient serum, cell cultures and viral vaccines Identification of pestiviruses contaminating cell lines and fetal calf sera Bovine polyomavirus, a frequent contaminant of calf serum Bovine polyomavirus, a frequent contaminant of calf sera A virus discovery method incorporating DNase treatment and its application to the identification of two bovine parvovirus species Identification of novel porcine and bovine parvoviruses closely related to human parvovirus 4 The association of calf serum with the contamination of BHK21 clone 13 suspension cells by a parvovirus serologically related to the minute virus of mice (MVM) Replication of bovine herpesvirus type 4 in human cells in vitro Bovine herpesvirus type 4: a special herpesvirus (review article)
    • keywords: acute; adventitious; amsterdam-1; assay; batch; bgm; bovine; cells; clinical; cmv; commercial; complete; contaminated; contamination; coronavirus; cpe; cultures; cv-1; cytomegalovirus; data; day; days; detection; deterioration; different; disease; dna; donor; electron; epithelial; figure; formation; free; growth; hcov; hek-293; herpesvirus; high; hre; hrs; human; identification; infected; infection; isolation; kidney; kit; laboratory; lednicky; lines; llc; mdck; media; medium; microscopy; mk2; mk2 cells; mv1; mycoplasma; new; nl63; novel; nuclei; particles; pcr; pcr1; plaque; porcine; presence; present; primary; primers; purified; renal; replication; respiratory; rna; rptec; rptec/2004; sars; sequence; serum; severe; study; sv40; syncytia; syndrome; table; titers; trypsin; type; vacuolation; vacuoles; vero; viral; virus; viruses; wi-38; work; ° c
    • versions: original; plain text
77. cord-291960-1is0rv6c
    • author: Piñana, José Luis
    • title: Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia
    • date: 2019-02-21
    • words: 5916
    • flesch: 36
    • summary: The assessment of the performance of quantitative CMV DNA PCR testing for the diagnosis of CMV pneumonia faces several difficulties including: (i) the low incidence of this clinical event, (ii) the lack of a normalized procedure for CMV DNA PCR testing on BAL fluids, (iii) the non-negligible possibility of miscategorization of pneumonia cases as either being causally linked or unrelated to CMV when using BAL fluid specimens, or even lung tissue material, for CMV diagnosis, 8 (iv) the persistence of a large variability of CMV DNA loads provided by different real-time PCR assays, 31 -33 despite their calibration to the WHO International Standard for CMV DNA 24 and, as already mentioned, (v) the relegation of virological procedures for CMV detection in clinical specimens. In 41 episodes, CMV DNA BAL detection occurred in the face of an ongoing episode of CMV DNAemia (including two episodes that occurred in the setting of autopsy-proven CMV pneumonitis), and isolately in the remaining 15 episodes.
    • keywords: allo; allogeneic; antiviral; assay; attributable; bal; bal fluid; bronchoalveolar; cases; cell; clinical; cmv; cmv dna; cmv pneumonia; cut; cytomegalovirus; data; day; days; detection; diagnosis; disease; dna; dna load; dnaemia; episodes; fluid; fluid specimens; fungal; hematopoietic; hsct; impact; incidence; infection; lavage; levels; load; lung; median; mortality; non; patients; pcr; plasma; pneumonia; preemptive; presence; probable; proven; pulmonary; quantitation; range; recipients; samples; sampling; shedding; specimens; standard; stem; study; supplementary; table; testing; therapy; time; tissue; transplant; transplantation; treatment; unlikely; usa; value
    • versions: original; plain text
78. cord-293886-gbv1ipmn
    • author: Cunha, Burke A.
    • title: Severe cytomegalovirus (CMV) community-acquired pneumonia (CAP) in a nonimmunocompromised host
    • date: 2008-10-01
    • words: 2795
    • flesch: 39
    • summary: [13] [14] In the compromised host with impaired CMI, CMV CAP pneumonia presents early (Ͻ48 hours) with fever and profound/prolonged hypoxemia with minimal or no pulmonary infiltrates. The diagnosis of CMV CAP was made serologically by demonstrating highly elevated IgM CMV titers.
    • keywords: acute; adenovirus; atypical; bacterial; cap; case; chest; clinical; cmv; community; cytomegalovirus; diagnosis; disease; elevated; function; gradient; hiv; host; immunocompetent; impaired; infection; infiltrates; influenza; lymphopenia; negative; pathogens; patients; pneumonia; present; pulmonary; ray; relative; respiratory; serum; severe; titers; transaminases; viral; virus
    • versions: original; plain text
79. cord-296402-rd5clf8h
    • author: José Castón, Juan
    • title: Efectos de la infección viral en el paciente trasplantado
    • date: 2007-10-31
    • words: 11021
    • flesch: 39
    • summary: El hecho de que la viremia desaparezca con la generación de anticuerpos, ha llevado a la inclusión de la inmunoglobulina intravenosa en el tratamiento de la enfermedad por parvovirus B-19 69 . b) Los aerosoles de ribavirina pueden emplearse en el tratamiento de la infección por VRS. c)
    • keywords: actualidad; además; administración; adn; adquisición; adultos; afectación; algunos; allograft; alto; anticipada; antiviral; aparecer; aparición; asociado; así; aunque; año; b-19; baja; barr; cada; carga; casos; cell; clínica; cmv; como; como la; complicaciones; con; con el; con la; crónica; cuales; cuando; cultivo; cytomegalovirus; células; datos; de elpt; de enfermedad; de infección; de la; de los; de un; debido; del; desarrollo; desde; después; detección; diagnóstico; diagnóstico de; disease; disfunción; disminución; disorder; donante; durante; efectos; effects; eficaz; eich; el caso; el diagnóstico; el empleo; el riesgo; el trasplante; el tratamiento; el virus; elpt; embargo; empleado; emplearse; empleo; empleo de; en el; en la; en los; en pacientes; encuentra; enfermedad; enfermedad por; entre; entre el; epstein; especialmente; específicas; esta; estado; este; estos; estrategia; estudios; evidenciado; existen; exposición; factores; forma; foscarnet; frecuente; frente; fundamentalmente; fármacos; ganciclovir; general; generalmente; grado; han; hasta; hbs; hecho; hepatitis; hepático; herpesvirus; human; igualmente; importante; incidencia; indirectos; infecciones; infección; infección por; infection; influenza; injerto; inmune; inmunoglobulina; inmunosupresión; intensidad; intravenosa; invasora; kaposi; la elpt; la enfermedad; la infección; la intensidad; la presencia; la profilaxis; lamivudina; las; latente; linfocitos; liver; los; los casos; los pacientes; los que; lymphoproliferative; manifestaciones; mayor; mayoría; mediante; menor; meses; momento; monitorización; mortalidad; más; métodos; nefropatía; ocasiones; oral; organ; otros; pacientes; pacientes trasplantados; para; para el; para la; parvovirus; patients; pautas; pcr; período; población; por; por cmv; por el; por la; por virus; postrasplante; posttransplant; precoz; presencia; presentan; prevención; primaria; primeros; profilaxis; prophylaxis; prospective; puede; que; quimioterapia; reactivación; receptores; receptores de; rechazo; reciben; recipients; recomienda; renal; renales; replicación; requiere; respecto; respuesta; resulta; ribavirina; riesgo; riesgo de; risk; rituximab; sarcoma; se ha; semanas; ser; seronegativos; seropositivos; seroprevalencia; sido; siendo; sin; sobre; solid; sometidos; son; study; supervivencia; síntomas; tanto; tardía; tasas; terapia; tipo; tph; transmisión; transplantation; trasplantados; trasplante; tratamiento; través; técnicas; una; vacunación; veb; vez; vhb; vhc; vhh-6; vhs; viral; viremia; virus; virus de; vrs; vvz; y de; y el; y la; zóster; órgano
    • versions: original; plain text
80. cord-304066-rirbdhz3
    • author: Reddehase, Matthias J.
    • title: Adverse immunological imprinting by cytomegalovirus sensitizing for allergic airway disease
    • date: 2019-05-10
    • words: 1896
    • flesch: 35
    • summary: The findings suggests that by this door opener function, CMV airway infection may broaden the spectrum of potential allergens. mCMV airway infection alone did not trigger AAD, nor did the combination of OVA-sensitization and OVA re-exposure.
    • keywords: aad; activation; airway; allergen; allergic; antigen; asthma; cdc; cells; clinical; cmv; cytomegalovirus; disease; environmental; exposure; hcmv; host; infection; inhaled; low; mcmv; metaplasia; model; mouse; mucosa; mucus; murine; ova; sensitization; specific; th-2; transmission; viral
    • versions: original; plain text
81. cord-305085-bv7udg9k
    • author: Lawrence, Robert M.
    • title: Chapter 13 Transmission of Infectious Diseases Through Breast Milk and Breastfeeding
    • date: 2011-12-31
    • words: 45867
    • flesch: 41
    • summary: Experience from the Finnish HPV family study Streptococcal toxic shock syndrome, including necrotizing fasciitis and myositis Late-onset septicemia in a Norwegian national cohort of extremely premature infants receiving very early full human milk feeding Hepatitis A outbreak in a neonatal intensive care unit: Risk factors for transmission and evidence of prolonged viral excretion among preterm infants Characterization of a novel corona virus associated with severe acute respiratory syndrome Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease Attempts to detect RNA tumour virus in human milk Is breast milk collected at home suitable for raw consumption by neonates in Brizilian public neonatal intensive care units? Prevalence of HIV-1 DNA and p24 antigen in breast milk and correlation with maternal factors Follow-up of transmission of hepatitis C to babies of human immunodeficiency virus-negative women: The role of breastfeeding in transmission Occurrence of acute diarrhea in atopic and nonatopic infants: role of prolonged breast-feeding An outbreak of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit Hospital transmission of community acquired methicillin-resistant Staphylococcus aureus among postpartum women Removal of inhibitors against RNA-directed DNA polymerase activity in human milk Effect of human milk on mouse mammary tumor virus Human papillomavirus DNA detected in breast milk Control of a cluster of a community-associated methicillin-resistant Stahpylococcus aureus in neonatology Immunoglobulin prophylaxis against milkborne transmission of human T cell leukemia virus type 1 in rabbits Chlamydial infections Pregnancy and pulmonary tuberculosis Possible breast milk transmission of group B streptococcal infection Evidence for transmission of lymphocyte responses to tuberculin by breast-feeding, Lancet I:529 Toxic shock syndrome Detection of Borrelia burgdorferi DNA by PCR in the urine and breast milk of patients with Lyme borreliosis Prevention of perinatal group B streptococcal disease. One case of brucellosis in an infant caused by breast milk transmission, with B. melitensis isolated from the breast milk, before antibiotic treatment was given to the mother has been documented.
    • keywords: absence; acceptable; acquisition; active; acute; additional; adults; africa; age; agents; airborne; analysis; antibodies; antibody; antigen; antiretroviral; appropriate; areas; associated; association; asymptomatic; aureus; authors; available; bacterial; benefits; birth; blood; bottle; botulism; breast cancer; breast infection; breast lesions; breast milk; breastfed; breastfed infants; breastfeeding; brucellosis; c virus; care; careful; cases; cause; cells; cesarean; chapter; children; chronic; clinical; close; cmv; collection; colonization; colonized; colostrum; committee; common; community; complete; congenital; congenital infection; contact; contamination; continued; control; countries; course; culture; culturing; cytomegalovirus; cytomegalovirus infection; data; days; death; decrease; delivery; dengue; dengue virus; developed; development; diagnosis; diarrhea; different; difficult; direct; discussion; disease; dna; documented; dose; droplet; duration; e.g.; early; ebv; effect; effective; empiric; endemic; epidemiologic; et al; evaluation; evidence; exclusive; exclusive breastfeeding; exposure; expressed; factors; fetus; fever; fever virus; fluids; follow; formula; free; gbs; general; greater; group; hav; hbv; hcv; hdv; health; hemorrhagic; hepatitis; herpes; hev; hgv; high; higher; history; hiv; hiv infection; hiv transmission; hiv-1; home; hospital; hospitalized; hours; household; hpv; htlv; human breast; human milk; humans; igm; illness; illnesses; immune; immunization; immunodeficiency; immunodeficiency virus; important; incidence; increased; individuals; infancy; infant transmission; infants; infants younger; infected; infection; infection control; information; intensive; interventions; intrapartum; invasive; involvement; isolation; isoniazid; laboratory; lack; lactating; lactation; large; late; lesions; leukemia; life; likely; literature; load; low; lower; lyme; lymphotropic; malaria; management; mastitis; maternal; maternal infection; measles; medical; methicillin; mild; milk samples; months; morbidity; mortality; mother; mrsa; mumps; negative; neonatal; neonates; newborn; nile; nile virus; number; nursery; observation; occurrence; older; ongoing; onset; oral; organism; outbreaks; patients; pcr; perinatal; period; person; pneumonia; poliovirus; positive; positive mothers; possible; postnatal; postnatal infection; postnatal transmission; postpartum; potential; precautions; pregnancy; pregnant; premature; premature infants; prenatal; presence; preterm; prevalence; prevention; primary; products; prolonged; prophylaxis; protective; rabies; range; rare; rash; rates; reasonable; recent; recommendations; regimens; related; relative; reported; reports; resistant; respiratory; response; results; risk; role; rotavirus; routine; rsv; saliva; samples; sars; secondary; secretions; separation; sequelae; seropositive; serum; severe; severity; shock; short; significant; similar; single; situations; skin; smallpox; source; south; species; specific; spread; standard; staphylococcus; states; streptococcal; studies; study; subsequent; support; survival; symptoms; syndrome; syphilis; term; testing; therapy; time; timing; toxin; tract; transmammary; transmission; transmission breast; transmission rate; transplacental; treatment; tst; ttv; tuberculosis; type; uncommon; united; urine; use; vaccination; vaccine; vaccine virus; vaccinia; varicella; vertical transmission; viral; virus; virus infection; virus transmission; virus type; viruses; weaning; weeks; west; women; world; years; yellow; younger; zidovudine; zoster; zoster virus
    • versions: original; plain text
82. cord-307016-4hdsb5oq
    • author: Allen, Upton
    • title: Prevention and Treatment of Infectious Complications After Solid Organ Transplantation in Children
    • date: 2010-04-30
    • words: 6747
    • flesch: 28
    • summary: The diagnosis of CMV infection and disease in organ transplant recipients can be affected by the variable lack of sensitivity and/or specificity of different diagnostic tests. Valganciclovir dosing according to body surface area and renal function in pediatric solid organ transplant recipients Epstein-Barr virus infections Epstein-Barr virus-associated multifocal leiomyosarcomas arising in a cardiac transplant recipient: autopsy case report and review of the literature Management of Epstein-Barr virus-induced posttransplant lymphoproliferative disease in recipients of solid organ transplantation New developments in the diagnosis and management of posttransplantation lympholiferative disorders in solid organ transplant recipients Adenoviral infections in pediatric transplant recipients: a hospital-based study Adenovirus infections Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation Sustained BK viruria as an early marker for the development of BKV-associated nephropathy: analysis of 4128 urine and serum samples Quantitative viral load monitoring and cidofovir therapy for the management of BK virus-associated nephropathy in children and adults Varicella Zoster infection in solid organ transplant recipients: a hospital-based retrospective study Varicella zoster virus Sustainability of humoral responses to varicella vaccine in pediatric transplant recipients following a pre-transplantation immunization strategy Varicella-zoster infections Respiratory syncytial virus infections in pediatric liver transplant recipients Parainfluenza and influenza virus infections in pediatric organ transplant recipients
    • keywords: acyclovir; agents; antimicrobial; bacterial; blood; centers; children; clinical; cmv; common; community; complications; consensus; consequences; data; diagnosis; disease; donor; ebv; evaluation; examination; experience; factors; fever; ganciclovir; general; h1n1; heart; hepatitis; immune; immunosuppression; important; incidence; individuals; infection; influenza; invasive; limited; liver; lung; major; management; months; organ; organ transplant; organ transplantation; outcomes; pandemic; pathogens; patients; pediatric; pediatric transplant; period; pneumocystis; pneumonia; posttransplant; potential; presence; prevention; prophylaxis; ptld; recipients; rejection; renal; respiratory; result; review; risk; safety; screening; solid; specific; strategies; table; testing; therapy; time; tract; transplant; transplant patients; transplant recipients; transplantation; treatment; tuberculosis; use; vaccination; vaccine; varicella; viral; virus; zoster
    • versions: original; plain text
83. cord-310217-p9nqcz5d
    • author: Nikolina, Basic-Jukic
    • title: Can hyperimmune anti-CMV globuline substitute for convalescent plasma for treatment of COVID-19?
    • date: 2020-05-31
    • words: 649
    • flesch: 29
    • summary: Data on file The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis Convalescent plasma as a potential therapy for COVID-19 Effectiveness of convalescent plasma therapy in severe COVID-19 patients Convalescent plasma therapy, has been used in treatment of numerous infectious diseases including SARS and MERS pandemic (3) .
    • keywords: anti; cmv; convalescent; covid-19; hyperimmune; infection; patients; plasma; recipients; renal; transplant; treatment
    • versions: original; plain text
84. cord-311505-akcc9oms
    • author: Geisen, Will R.
    • title: Cytomegalovirus Enterocolitis secondary to experimental COVID-19 therapy
    • date: 2020-09-22
    • words: 1359
    • flesch: 29
    • summary: With immunomodulating therapies being used in experimental protocols and clinical trials for SARS-CoV-2 J o u r n a l P r e -p r o o f infection, colonoscopy is vital to diagnose gastrointestinal opportunistic infections that are associated with these treatment modalities Clinical Characteristics of Coronavirus Disease 2019 in China A Novel Coronavirus from Patients with Pneumonia in China Tocilizumab for the treatment of severe COVID-19 Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 Clostridioides difficile in COVID-19 patients In vivo effects of the anti-interleukin-6 receptor inhibitor tocilizumab on the B cell compartment Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization Novel Coronavirus Infection: Gastrointestinal Manifestations Pooled Prevalence of Diarrhea among COVID-19 Toward an Algorithm for the Diagnosis and Management of CMV in Patients with Colitis The occurrence of diarrhea in COVID-19 patients Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology Excessive anxiety in IBD patients is unnecessary for COVID-19 Dear Editor-in-Chief,We are submitting the manuscript Cytomegalovirus Enterocolitis secondary to experimental COVID-19 therapy for consideration of publication as a Case Report. Additionally, studies have shown a significant alteration of gut microbiome and increased rates of C. difficile in COVID-19 patients, most presumably from immunomodulating therapies (6, 8) .
    • keywords: case; clinical; cmv; colitis; colonoscopy; coronavirus; cov-2; covid-19; cytomegalovirus; data; diarrhea; experimental; gastrointestinal; high; hydroxychloroquine; infectious; mortality; novel; pandemic; patients; pcr; positive; respiratory; sars; therapies; tocilizumab; worldwide
    • versions: original; plain text
85. cord-313474-1gux1gsi
    • author: None
    • title: Physicians Abstracts
    • date: 2015-03-20
    • words: 51535
    • flesch: 53
    • summary: TRM at 1 year was 9% in Arm A, and 15% in Arm B and 16% in Arm C. Two year OS and DFS for each arm are: arm A -62.2% and 56%; arm B -68% and 59% and 48% and 48% for arm C. For the 115 pts who received standard risk transplants (i.e., pts with high risk forms of AML, ALL or NHL in 1 o CR, AML in 2 o CR, MDS RA/RCMD, CML in 1 o CP or MM in CR1), 2 year OS and DFS are: arm A -60% and 59%; arm B -74% and 65%; arm C -50% and 50%, with relapse rates at 2 yrs of arm All pts engrafted promptly (median d þ 10, range þ 9 -þ 12).TRM (grade II-IV) at 12mos is 18% (95% CI: 8% -31%).
    • keywords: 4g7sdie; absence; active; activity; acute; acute gvhd; additional; administration; adult; adv; advanced; adverse; age; aim; alemtuzumab; allele; allogeneic; allosct; alternative; aml; analysis; anemia; anti; antibodies; antibody; antigen; apheresis; approach; arm; asct; assessment; association; atg; autologous; available; beam; benefit; better; blasts; blood; bone; bortezomib; brca; breast; bright; busulfan; cancer; car; cars; cases; cause; cbt; cd19; cd34; cd34 þ; cd4; cd56; cd8; cell transplantation; cells; centers; centres; characteristics; chemotherapy; children; chronic; chronic gvhd; clinical; cmv; cobe; cohort; collection; common; comparable; comparison; complete; complications; conclusion; conditioning; consecutive; control; conventional; cord; count; course; cr1; criteria; cs1; csf; cumulative; cyclophosphamide; cyclosporine; cytogenetics; cytometry; data; day þ; days; death; del(8)(p21; depletion; development; device; dfs; diagnosis; differences; different; directional; disclosure; disease; disease relapse; dli; donation; donor; dose; dsa; early; ebmt; ebv; effective; effector; effects; efficacy; engraftment; events; evidence; expansion; expression; factors; failure; feasible; female; figure; flow; fludarabine; follow; following; free; fresenius; function; genes; genotype; gpi; grade; graft; group; gvhd; hadv; haplo; haploidentical; hct; hdct; healthy; hematologic; hematopoietic; high; high risk; higher; hiv; hla; hospital; host; hr ¼; hrqol; hsct; human; iii; immune; immunosuppressive; impact; important; improved; incidence; increase; independent; induction; infections; influence; information; infusion; intensity; interest; introduction; involved; ist; ivbu; kb1; kir; lack; large; leukemia; levels; lfs; ligand; limited; line; liver; long; loss; lower; lymphocyte; lymphoma; mac; major; male; malignancies; marrow; matched; materials; mds; mean; median; median age; median follow; median time; medical; memory; methods; mice; migration; mir-155; mismatched; mm patients; mnc; mobilization; models; molecular; months; mortality; mrd; msd; mtx; mud; multiple; multivariate; mut; myeloablative; myeloid; myeloma; n ¼; need; negative; neutrophil; new; nhl; non; novel; nrm; number; observed; optia; optimal; option; order; outcome; overall; p ¼; patients; pbmc; pbsc; pcr; pdc; pediatric; performance; period; peripheral; pet; pfs; phase; phenotype; platelet; plerixafor; po0.001; points; poor; population; positive; post; potential; pre; predictive; presence; present; previous; primary; prior; probability; procedure; prognostic; progression; prophylaxis; proportion; prospective; protocol; pts; randomized; range; rate; ratio; reactivation; receptor; recipients; reconstitution; recovery; reduced; reduction; refractory; regimen; regulatory; relapse; related; remission; renal; reported; response; results; retrospective; ric; risk; risk patients; role; ruxolitinib; saa; safety; salvage; samples; score; screening; second; secondary; selection; serum; setting; severe; short; sibling; significant; similar; single; skin; small; source; specific; spectra; standard; statistical; status; stem; stem cell; strategies; strategy; studies; study; subgroups; subjects; subsequent; subsets; survival; survivors; sustained; syndrome; system; t cells; t ¼; table; target; tbi; tcr; term; test; thalassemia; therapeutic; therapy; thiotepa; time; tma; tnfr2; total; toxicity; transduced; transplantation; transplants; treatment; tregs; trend; trial; trm; tumor; type; ucb; unit; university; unrelated; urd; use; variables; versus; viability; viral; virus; vitro; vivo; vod; vs.; weeks; weight; wt1; y.o; years; yrs; þ cell; þ t
    • versions: original; plain text
86. cord-315304-pge45105
    • author: Kotton, C.N.
    • title: Organ Transplantation, Risks
    • date: 2015-03-06
    • words: 4213
    • flesch: 26
    • summary: Studies of viral latency, reactivation, and of the cellular effects of viral infection will provide clues for future strategies in prevention and treatment of viral infections. Viral infection is associated with both direct (invasive disease) and indirect (immune modulation) effects affecting susceptibility to other infections and promoting allograft rejection.
    • keywords: active; allograft; antiviral; assays; blood; cell; cellular; clinical; cmv; common; diagnosis; disease; donor; ebv; effects; expression; factors; fever; general; graft; hepatitis; hhv-6; hiv; host; hsct; illness; immune; immunity; immunosuppression; impact; indirect; infection; injury; latency; latent; level; major; molecular; organ; patients; post; primary; prophylaxis; reactivation; recipients; rejection; renal; replication; respiratory; responses; risk; significant; solid; sot; specific; therapy; tissue; transplantation; treatment; viral; viral infection; virus; viruses; vzv
    • versions: original; plain text
87. cord-323691-5s5almd2
    • author: Mishin, Vasiliy P
    • title: A ‘minimal’ approach in design of flavivirus infectious DNA
    • date: 2001-12-04
    • words: 5068
    • flesch: 41
    • summary: Hum Intron insertion facilitates amplification of cloned virus cDNA in Escherichia coli while biological activity is reestablished after transcription in vivo An enhancer in the first intron of the human purine nucleoside phosphorylase-encoding gene Synthesis and characterization of an infectious dengue virus type-2 RNA genome Phylogeny of the genus Flavivirus Construction of a stable and highly infectious intron-containing cDNA clone of plum pox potyvirus and its use to infect plants by particle bombardment An artificial enhancer with multiple response elements stimulates prokaryotic transcriptional activation medicated by various regulatory proteins Nucleotide sequence of the virulent SA-14 strain of Japanese encephalitis virus and its attenuated vaccine derivative, SA-14-14-2 Nucleotide sequence and infectious cDNA clone of the L1 isolate of Pea seed-borne mosaic potyvirus Infectious RNA transcripts from full-length dengue virus type 2 cDNA clones made in yeast In vitro processing of dengue virus type 2 nonstructural proteins NS2A, NS2B, and NS3 Cloned poliovirus complementary DNA is infectious in mammalian cells Flaviviridae: the viruses and their replication Transcription of infectious yellow fever RNA from fulllength cDNA templates produced by in vitro ligation Modulations of the in vitro translational efficiencies of Yellow Fever virus mRNAs: interactions between coding and noncoding regions Assaying the polyadenylation state of mRNAs Molecular Cloning: A Laboratory Manual Alphavirus vectors for gene expression and vaccines Production of infectious poliovirus from cloned cDNA is dramatically increased by SV40 transcription and replication signals Infectious Japanese encephalitis virus RNA can be synthesized from in vitro-ligated cDNA templates Complete nucleotide sequence of the Japanese encephalitis virus genome RNA Promoter-regulatory region of the major immediate early gene of human cytomegalovirus Stable high-level expression of heterologous genes In vitro and In vivo by noncytopathic DNA-based kunjin virus replicon vectors A new strategy in design of +RNA virus infectious clones enabling their stable propagation in E. coli We thank Dr S. Schlesinger for BHK-21 cells, Dr D. Trent for pM343 and pH756 plasmids, and Jennifer Ascañ o for help in manuscript preparation. key: cord-323691-5s5almd2 authors: Mishin, Vasiliy P; Cominelli, Fabio; Yamshchikov, Vladimir F title: A ‘minimal’ approach in design of flavivirus infectious DNA date: 2001-12-04 journal: Virus Research DOI: 10.1016/s0168-1702(01)00371-9 sha: doc_id: 323691 cord_uid: 5s5almd2 Abstract The ‘infectious DNA’ approach, which is based on in vivo transcription of (+)RNA virus genome cDNA cassettes from eukaryotic promoters in transfected cells, became a popular alternative to the classical scheme in the infectious clone methodology.
    • keywords: 5%-utr; activity; analysis; approach; bhk; cassette; cdna; cells; characteristics; clone; cmv; coli; construct; control; design; dna; effect; encephalitis; enhancer; et al; eukaryotic; expression; extension; fig; flavivirus; fragment; gene; genome; growth; infectious; infectivity; isolated; johansen; lopez; luciferase; manufacturer; minimal; parent; pcmvmpje(bghtt; pfu; plaques; plasmid; pos; primer; production; products; promoter; proteins; recovered; reverse; rna; sequence; specific; spurious; stability; substantial; transcription; transfection; viral; virus; viruses; yamshchikov
    • versions: original; plain text
88. cord-335692-5uxtua9o
    • author: Kilic, A.
    • title: Evaluation of the performance of DiaSorin molecular Pneumocystis jirovecii-CMV multiplex real-time PCR assay from bronchoalveolar lavage samples
    • date: 2020-01-31
    • words: 2400
    • flesch: 45
    • summary: PJIR kit, progenie molecular, to an in-house real-time PCR assay for the diagnosis of Pneumocystis jirovecii infections A Pneumocystis jirovecii pneumonia outbreak in a single kidney-transplant center: role of cytomegalovirus co-infection Cytomegalovirus in the bronchoalveolar lavage fluid of patients with AIDS Outcomes of non-HIV-infected patients with Pneumocystis pneumonia and concomitant pulmonary cytomegalovirus infection Diagnosis and management of pneumocystis pneumonia in resource-poor settings Pneumocystis jirovecii Pneumonia in Human Immunodeficiency Virus Infection Prevalence of Pneumocystis jirovecii among immunocompromised patients in hospitals of Tehran city Metaanalysis of diagnostic procedures for Pneumocystis carinii pneumonia in HIV-1-infected patients PCR diagnosis of Pneumocystis pneumonia: a bivariate meta-analysis Pneumocystis jirovecii pneumonia in non-HIVinfected patients: new risks and diagnostic tools prospective clinical evaluation of respiratory samples from subjects at risk for Pneumocystis jirovecii infection by use of a commercial realtime PCR assay Pneumocystis jirovecii testing by real-time polymerase chain reaction and direct examination among immunocompetent and immunosuppressed patient groups and correlation to disease specificity Assessment of cytomegalovirus and cell-mediated immunity for predicting outcomes in non-HIV-infected patients with Pneumocystis jirovecii pneumonia Medicine (Baltimore Human herpes virus co-infection is associated with mortality in HIV-negative patients with Pneumocystis jirovecii pneumonia Prognostic markers of short-term mortality in AIDS-associated Pneumocystis carinii pneumonia The PJ-CMV PCR assay detects both of these pathogens in a single sample, eliminating the need for a separate assay for CMV PCR testing in respiratory specimens.
    • keywords: assay; bal; clinical; cmv; detection; diasorin; direct; hiv; ifa; infection; jirovecii; molecular; negative; non; patients; pcr; pjp; pneumocystis; pneumonia; positive; real; samples; sensitivity; specificity; study; time
    • versions: original; plain text
89. cord-340228-mvqoyror
    • author: Al-Herz, Waleed
    • title: Spectrum of Viral Infections Among Primary Immunodeficient Children: Report From a National Registry
    • date: 2019-05-29
    • words: 2932
    • flesch: 34
    • summary: While most PIDs predispose to a wide spectrum of viral infections, certain diseases enhance vulnerability to specific viral infections (11) . Front Immunol DOI: 10.3389/fimmu.2019.01231 sha: doc_id: 340228 cord_uid: mvqoyror Objective: To present the frequency and spectrum of viral infections in primary immunodeficient children.
    • keywords: adenovirus; associated; cellular; children; clinical; cmv; combined; committee; common; diseases; disorders; dysregulation; ebv; group; health; hpv; humoral; immune; immunity; immunodeficiencies; immunodeficient; important; infections; kuwait; national; number; organisms; parainfluenza; patients; period; pid; pids; pneumonia; primary; registry; report; samples; significant; stool; study; viral; viremia; virus
    • versions: original; plain text
90. cord-340489-yo3cp5vs
    • author: None
    • title: KAPITEL 13 Infektionskrankheiten
    • date: 2008-12-31
    • words: 26587
    • flesch: 38
    • summary: ASL spielt in der Diagnostik des rheumatischen Fiebers nur eine geringe Rolle, ADB hat in der Diagnostik der akuten Glomerulonephritis größere Bedeutung. Antikörpernachweisverfahren (Mikroagglutination, ELISA, Westernblot) spielen in der Diagnostik der akuten Enterokolitiden keine wesentliche Rolle.
    • keywords: abb; aber; aber auch; abgenommen; abgrenzung; abhängig; ablauf; absetzen; abstand; abwehr; abwehrgeschwächten; abzugrenzen; acv; adb; adenoviren; aids; aktive; akuten; alle; allem bei; allerdings; allgemeine; als; als bei; alternative; alveoläre; aminosäuren; amphotericin; anderen; andererseits; angesichts; anhaltenden; ansonsten; anteil; antibakterielle; antibiotika; antibiotikatherapie; antigen; antikörper; antikörpernachweis; antiretroviralen; antiretroviralen therapie; antivirale; antivirale therapie; anwendung; art; asl; aspergillus; assoziiert; auch; auch bei; auch die; auch durch; auch für; auch nach; auch von; auf; auf der; auf eine; auf und; auffrischimpfungen; aufgrund; aufnahme; auftreten; auftritt; aus; aus dem; ausgelöst; ausgeschlossen; ausmaß; ausreichend; ausschließlich; ausschluss; außerdem; b. bei; b. die; bakterielle; bakterien; bauchschmerzen; bazilläre; bedeutung; bedingt; befall; befindet; befunde; beginn; begonnen; behandelt; behandelt werden; behandlung; behandlung der; bei; bei aids; bei denen; bei der; bei einer; bei einigen; bei erwachsenen; bei hiv; bei kindern; bei patienten; bei schweren; beide; beim; beispiel; bekannt; bekannten; beläge; beobachtet; bereich; bereits; berichtet; beruht; beschreibung; beschrieben; beschwerden; besitzen; besonderheit; besonders; besserung; bestehen; besteht; bestimmte; bestimmung; bestätigt; betroffen; beträgt; beurteilung; bezeichnet; bild; bilden; bildung; bis; bisher; bislang; bkv; bleiben; bleibt; blut; blutkultur; bse; bvdu; bzw; candida; carinii; cd4; ceftriaxon; cephalosporine; charakteristisch; chemische; chemotherapeutika; chemotherapie; chronische; cidofovir; cjd; cmv; coli; creutzfeldt; d.h; dabei; dadurch; dagegen; daher; damit; dann; dar; darm; das; dass; dazu; definition; dellwarzen; dem; denen; denkbar; der; der auch; der erkrankung; der erreger; der hiv; der infektion; der infizierten; der lunge; der nachweis; der regel; der therapie; der verlauf; der wahl; derzeit; des; deutlich; deutschland; diabetes; diagnose; diagnose einer; diagnostik; diagnostik der; diagnostik die; diagnostisches; die; die diagnose; die hiv; die von; die zur; diese; differentialdiagnose; diphtherie; disease; disseminierte; dna; doppelsträngige; dosierung; dosis; durch; durch den; durch die; durch eine; durchaus; durchfällen; durchführung; durchgeführt; durchgeführt werden; durchmesser; durchseuchung; ebenfalls; ebenso; ebv; effektiv; effektorzellen; eher; eigenschaften; eindringen; eine; eine antivirale; eine der; eine infektion; eine therapie; einfluss; einführung; eingesetzt; einige; einmal; einsetzbare; einteilung; einzelne; elisa; empfehlungen; empfohlen; empirische; endemiegebiete; entdeckt; enterica; enteroviren; entfernt; enthalten; enthält; entscheidend; entsprechende; entstehung; entweder; entwicklung; enzephalitis; enzephalopathie; epidemiologie; epidemiologischen; erfolgen; erfolgreich; erfolgt; erforderlich; erfordert; ergeben; erheblich; erhöht; erhöhung; erkennen; erkrankten; erkrankung ist; erkrankungen; ermöglicht; erprobt; erreger; erregernachweis; erreichen; erreicht; ersten; erwachsenen; erworbene; es bei; es nach; es nicht; es sich; es zur; etwa; europa; evtl; exanthem; exposition; expression; extrem; faktoren; familie; fast; fehlen; ferner; fieber; findet; fluconazol; folgenden; form; foscarnet; frage; frau; früher; frühzeitig; fähigkeit; fällen; führen; führt; für; für das; für den; für die; für eine; gabe; gabe von; ganciclovir; gastrointestinalen; gastrointestinaltraktes; gattung; gattungen; gcjd; gebildet; gefahr; gefunden; gegeben; gegen; gegensatz; gegenüber; gehirn; geht; gehäuft; gekennzeichnet; gelbfieber; gelegentlich; gelingt; generation; generell; genetischen; genitale; genom; genotypen; geringer; geschieht; gestellt; gewichtsabnahme; geworden; gezeigt; gezielte; ggf; gibt; gibt es; gilt; gleichzeitig; gramnegative; granulozyten; großbritannien; großen; grundsätzlich; gruppe; gss; gut; gute; haart; haben; hat; haut; hautveränderungen; hbv; hcv; helferzellen; hemmen; hemmung; hemmung der; hepatitis; hergestellt; herpesviren; hervorgerufen; heute; hhv-6; hier; hierfür; hierzu; hinweise; hinzu; histologisch; hiv; hoch; hodgkin; hoher; hpv; hsv; hsv-2; htlv-1; humane; hängt; häufig; häufiger; häufigste; i.v; ifn; igg; igm; ihrer; immer; immunantwort; immundefekten; immunfluoreszenz; immungesunden; immunisierung; immunität; immunkompetenten; immunschwäche; immunsuppression; immunsupprimierten; immunsystems; impfschutz; impfstoff; impfung; impfungen; indikationen; indiziert; induktion; infektion; infektion ist; infektion und; infektionen bei; infektionen durch; infektionen mit; infektionskrankheiten; infektiösen; infizierten; influenza; infolge; inkubationszeit; innerhalb; insbesondere; insgesamt; interferone; interstitielle; intravenös; intrazelluläre; invasiven; inzidenz; isolieren; isoliert; ist; ist aber; ist auch; ist bei; ist das; ist der; ist die; ist durch; ist eine; ist es; ist für; ist mit; ist nicht; jahren; jakob; jcv; je nach; jeder; jedoch; jähriger; jährlich; kann; kann bei; kann der; kann die; kann eine; kann es; kap; kaposi; katheter; kaum; kbr; kein; kenntnis; kindern; klassischen; klinischen; kombinationstherapie; kommen; kommt; kommt es; komplikationen; konjugat; konnte; kontakt; kontrolle; kopfschmerzen; kranken; krankheitsbild; kriterien; kulturelle; kuru; kurzen; können; labor; lang; lassen; latente; latenz; ldh; lebensjahr; lebensmonat; leber; leicht; leider; letalität; letzten; letztlich; leukopenie; leukozyten; liegt; liquor; lues; lunge; lymphadenopathie; lymphknoten; lymphknotenschwellungen; lymphome; lymphozyten; ländern; läsionen; lässt; macht; makrophagen; malaria; man; manifestation; masern; material; materialien; maßnahmen; mechanismen; medikamente; mehr; mehrere; meist; meist bei; meisten; meningitis; meningokokken; menschen; mikrobiologische; mindestens; mit; mit der; mit einer; mit sehr; mittel; mittlerweile; moleküle; monate; mononukleose; monozyten; mumps; muss; muss eine; mutanten; mutationen; möglich; möglicherweise; möglichkeit; möglichst; müssen; nach; nach der; nach einer; nach infektion; nachgewiesen; nachtschweiß; nachweis; nachweis von; natürliche; neben; neben der; nebenwirkungen; neisseria; nervensystems; neugeborenen; neurologische; nicht; nicht von; noch; non; normalen; notwendig; nukleosidanaloga; nur; nur bei; nur durch; nvcjd; nötig; oben; obligat; obwohl; oder; oder als; oder die; oder durch; oder mit; offenbar; oft; ohne; opportunistische; orale; organe; organismus; papillomaviren; parameter; pathogenese; pathogenität; pathogenitätsfaktoren; patienten; patienten mit; pcp; pcr; pcv; peg; penicillin; penicillinallergie; peripheren; persistierende; personen; pertussis; pharyngitis; phase; picornaviren; pilze; pilzinfektionen; pml; pneumocystis; pneumokokken; pneumonie; poliomyelitis; polymerase; positiv; primäre; primärinfektion; prinzip; prionen; prnp; probleme; produktive; prognose; prophylaktische; prophylaxe; proteine; prp; quantitative; rahmen; rasch; raschen; rate; reaktionen; reaktivierung; regel; reihe; reisen; relativ; replikation; resistenz; retroviren; reverse; ribavirin; rind; risiko; rna; rolle; salmonella; sarkom; scheint; schleimhaut; schleimhäuten; schmerzen; schon; schutz; schweren; sehr; sein; seit; sekundäre; selektion; selten; seltener; sensitivität; sepsis; serologie; serologisch; serotypen; serovare; serum; sich; sich auf; sich bei; sich der; sich die; sich durch; sich eine; sich nach; sicher; sie; sie ist; siehe; simplex; sind; sind bei; sind eine; sind für; sind häufig; sind von; sinnvoll; situationen; sofort; sog; sogar; solche; sollte; somit; sondern; sowie; spcjd; speichel; spektrum; spezielle; spezies; spezifische; spielen; spielt; sputum; später; stadium; standard; standardimpfungen; staphylokokken; stark; stehen; stellen; stiko; streptokokken; struktur; studien; stuhl; stunden; stämme; störungen; subsp; substanzen; symptomatische; symptome; syndrom; systemisch; säuglinge; tab; tage; teils; teilweise; test; therapeutisch; therapie; therapie ist; therapie nicht; therapie und; therapie von; therapie zu; therapiedauer; titer; tod; tode; transaminasen; transkriptase; transport; trimoxazol; tritt; tropica; trotz; tse; tuberkulose; tumoren; typhus; typische; typischerweise; u.u; umfasst; und; und auch; und bei; und der; und die; und eine; und für; und ist; und mit; und nach; und nicht; und sind; und von; und werden; unklar; unspezifischen; unter; unterscheiden; unterschiedlich; untersuchung; urin; usa; valacv; varizellen; verabreicht; verantwortlich; verbesserung; verbreitet; verdacht; vereinzelt; verfahren; verfügung; verlauf; verlaufen; verletzung; verläuft; vermehrt; vermeidung; vermindert; verminderung; verschiedene; verträglichkeit; verursacht; veränderungen; viele; vielfach; viraler; viren; virus; viruserkrankungen; virusinfektionen; viruslast; viruspartikel; virusvermehrung; vollständig; vom; von; von aids; von der; von einer; von hiv; vor; vordergrund; vorgehen; vorhanden; vorkommen; vorkommenden; vorliegen; vzv; wahl; wahrscheinlichkeit; war; waren; wegen der; weitere; welche; weltweit; weniger; wenn; werden; werden als; werden bei; werden die; werden durch; werden kann; werden können; werden nach; werden von; wert; wesentlich; wichtige; wichtigsten; wie; wie bei; wieder; wird; wird bei; wird durch; wird eine; wirken; wirksame; wirksamkeit; wirtszelle; wobei; wochen; wurde; während; während der; z. b.; zahl; zeichen; zeigen; zeigt; zeitliche; zeitpunkt; zellen; zellulären; zentrale; ziel; zns; zoster; zu den; zu einer; zu sein; zugelassen; zum; zumindest; zunehmende; zunächst; zur; zurzeit; zurück; zusammenhang; zustand; zusätzlich; zwar; zwei; zwischen; zystische; ähnlich; ätiologie; äußert; über; übertragung; überwiegend; übrigen
    • versions: original; plain text
91. cord-342000-h4jo2bir
    • author: Aggarwal, Ashim
    • title: Early Cardiac Allograft Vasculopathy: Are the Viruses to Blame?
    • date: 2012-05-31
    • words: 1834
    • flesch: 34
    • summary: The Registry of the International Society for Heart and Lung Transplantation: twenty-seventh official adult heart transplant report-2010 Cardiac allograft vasculopathy: advances in diagnosis Cardiac allograft vasculopathy: pathology, prevention and treatment Cardiac allograft vasculopathy: recent developments The role of viruses in cardiac allograft vasculopathy Viral infection induces de novo lesions of coronary allograft vasculopathy through a natural killer cell-dependent pathway Prophylaxis versus preemptive anti-cytomegalovirus approach for prevention of allograft vasculopathy in heart transplant recipients Positive pretransplantation cytomegalovirus serology is a risk factor for cardiac allograft vasculopathy in children Does cytomegalovirus serology impact outcome after pediatric heart transplantation? Coronary heart disease, Helicobacter pylori, dental disease, Chlamydia pneumoniae, and cytomegalovirus: metaanalyses of prospective studies Chlamydia pneumoniae IgG titres and coronary heart disease: prospective study and meta-analysis Effects of total pathogen burden on coronary artery disease risk and Creactive protein levels Prospective study of pathogen burden and risk of myocardial infarction or death Impact of viral and bacterial infectious burden on long-term prognosis in patients with coronary artery disease A prospective molecular surveillance study evaluating the clinical impact of community-acquired respiratory viruses in lung transplant recipients CAV and graft failure are the leading cause of death in patients who survive the first year after transplant.
    • keywords: allograft; burden; cardiac; case; cav; cmv; coronary; death; disease; early; ebv; evidence; failure; heart; herpes; history; infection; months; multiple; negative; patient; positive; rejection; respiratory; risk; symptoms; term; transplant; transplantation; vasculopathy; ventricular; viral; viruses; year
    • versions: original; plain text
92. cord-347064-ljd121no
    • author: José, Ricardo J.
    • title: Opportunistic bacterial, viral and fungal infections of the lung
    • date: 2016-05-05
    • words: 2953
    • flesch: 27
    • summary: Opportunistic lung infections are a major cause of morbidity and mortality for patients immunocompromised because of HIV infection, haematological malignancy, aplastic anaemia or chemotherapy treatment, or who are recipients of solid-organ or stem cell transplants, and also can complicate treatment with the new biological therapies for inflammatory conditions. In selected patients, early bronchoscopy increases the yield of microbiological identification of a potential pathogen C Prolonged high-dose glucocorticoids (>20 mg/day for >21 days) predispose to Pneumocystis jirovecii pneumonia (PJP) C Biological agents are associated with specific immune defects that increase the risk of opportunistic lung infections (e.g. tumour necrosis factor-a inhibitors and risk of mycobacterial disease, endemic fungi and Legionella pneumophila; anti-CD20 drugs and mycobacterial disease, cytomegalovirus pneumonitis and PJP
    • keywords: antigen; aspergillosis; aspergillus; bacterial; balf; blood; candida; cause; cell; chest; chronic; clinical; cmv; common; consolidation; conventional; cough; culture; defects; diagnosis; disease; fever; fungi; high; hosts; immune; immunity; immunocompromised; infection; infiltrates; invasive; ipa; jirovecii; likely; lung; mortality; non; opportunistic; pathogens; patients; pcr; pneumonia; pneumonitis; positive; prolonged; pulmonary; radiological; respiratory; risk; samples; severe; species; specific; symptoms; treatment; viral
    • versions: original; plain text
93. cord-347761-wgodcsav
    • author: Cant, Andrew
    • title: Infections in the Immunocompromised
    • date: 2009-10-24
    • words: 5993
    • flesch: 35
    • summary: Pneumonitis and bronchiolitis are the most common presentations of respiratory infection, but lobar pneumonia may also occur. A review of respiratory viral infection in children with primary immune deficiencies in a HSCT unit found 22 of 73 patients admitted for HSCT had respiratory viral infection.
    • keywords: adenovirus; agents; antibiotic; appropriate; aspergillus; associated; bacteria; bal; biopsy; blood; cases; catheter; cause; cell; children; clinical; cmv; cryptosporidium; cvc; cvcs; diagnosis; different; difficult; disease; ebv; example; febrile; fungal; ganciclovir; gastrointestinal; hhv6; high; hiv; host; hsct; identification; immune; immunocompetent; immunocompromised; important; infection; influenza; intravenous; management; marrow; mortality; negative; neutropenia; non; number; organisms; patients; pcp; pcr; pneumocystis; pneumonia; primary; prophylaxis; recent; respiratory; review; ribavirin; risk; rsv; secretions; significant; signs; species; specific; stream; study; symptoms; therapy; tract; transplant; transplantation; treatment; unit; useful; viral; virus; viruses; vzv
    • versions: original; plain text
94. cord-348130-t9tysvr8
    • author: Cho, Sung-Yeon
    • title: Infectious complications after hematopoietic stem cell transplantation: current status and future perspectives in Korea
    • date: 2018-02-27
    • words: 9721
    • flesch: 31
    • summary: A prospective study on the predictive value of plasma BK virus-DNA load for hemorrhagic cystitis in pediatric patients after stem cell transplantation Late-onset hemorrhagic cystitis in children after hematopoietic stem cell transplantation for thalassemia and sickle cell anemia: a prospective evaluation of polyoma (BK) virus infection and treatment with cidofovir BK polyomavirus-associated hemorrhagic cystitis among pediatric allogeneic bone marrow transplant recipients: treatment response and evidence for nosocomial transmission Treatment of BK virus-associated hemorrhagic cystitis in pediatric hematopoietic stem cell transplant recipients with cidofovir: a single-center experience Low dosage cidofovir without probenecid as treatment for BK virus hamorrhagic cystitis after hemopoietic stem cell transplant Low-dose cidofovir in the treatment of symptomatic BK virus infection in patients undergoing allogeneic hematopoietic stem cell transplantation: a retrospective analysis of an algorithmic approach Treatment of BK virus-associated hemorrhagic cystitis with low-dose intravenous cidofovir in patients undergoing allogeneic hematopoietic cell transplantation Low-dose cidofovir treatment of BK virus-associated hemorrhagic cystitis in recipients of hematopoietic stem cell transplant Brincidofovir (CMX001) inhibits BK polyomavirus replication in primary human urothelial cells Respiratory viral infections in hematopoietic stem cell and solid organ transplant recipients Respiratory viral infections in transplant and oncology patients Utilization of the respiratory virus multiplex reverse transcription-polymerase chain reaction test for adult patients at a Korean tertiary care center Lower respiratory tract diseases caused by common respiratory viruses among stem cell transplantation recipients: a single center experience in Korea Management of RSV infections in adult recipients of hematopoietic stem cell transplantation ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus The characteristics and outcomes of parainfluenza virus infections in 200 patients with leukemia or recipients of hematopoietic stem cell transplantation Parainfluenza virus infections after hematopoietic stem cell transplantation: risk factors, response to antiviral therapy, and effect on transplant outcome Outcome of pandemic H1N1 infections in hematopoietic stem cell transplant recipients Risk factors for pneumonia in immunocompromised patients with influenza European guidelines for prevention and management of influenza in hematopoietic stem cell transplantation and leukemia patients: summary of ECIL-4 Upper and lower respiratory tract infections by human enterovirus and rhinovirus in adult patients with hematological malignancies Rhinovirus as a cause of fatal lower respiratory tract infection in adult stem cell transplantation patients: a report of two cases BCSH/BSBMT/ UK clinical virology network guideline: diagnosis and management of common respiratory viral infections in patients undergoing treatment for haematological malignancies or stem cell transplantation Guideline on the prevention and control of seasonal influenza in healthcare setting Clinical practice guideline for antiviral treatment and chemoprophylaxis of seasonal influenza Community acquired respiratory virus infections in cancer patients-guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology Immunodeficiency scoring index to predict poor outcomes in hematopoietic cell transplant recipients with RSV infections Palivizumab treatment of respiratory syncytial virus infection after allogeneic hematopoietic stem cell transplantation Oral GS-5806 activity in a respiratory syncytial virus challenge study Severe influenza treatment guideline The risk of tuberculosis in transplant candidates and recipients: a TBNET consensus statement The demanding attention of tuberculosis in allogeneic hematopoietic stem cell transplantation recipients: high incidence compared with general population Long-term risk of tuberculosis in haematopoietic stem cell transplant recipients: a 10-year nationwide study Infections caused by mycobacterium tuberculosis in recipients of hematopoietic stem cell transplantation Tuberculosis in hematopoietic stem cell transplant recipients in Korea Vaccinations in patients with hematological malignancies A comprehensive review of immunization practices in solid organ transplant and hematopoietic stem cell transplant recipients Vaccination of hematopoietic stem cell transplantation recipients: perspective in Korea BKV-associated hemorrhagic cystitis is predominant in allogeneic HSCT patients, and BKV-associated nephropathy in KT patients.
    • keywords: acute; addition; agents; allogeneic; antimicrobial; antiviral; aspergillosis; aspergillus; autologous; bacteria; bkv; blood; bloodstream; cancer; carbapenem; cases; cell; cell transplantation; center; chronic; cidofovir; clinical; cmv; common; complications; crv; cystitis; cytomegalovirus; data; days; diagnosis; diseases; drug; early; engraftment; epidemiology; factors; fever; fluoroquinolone; fungal; guidelines; gvhd; hematologic; hematopoietic; hematopoietic stem; hemorrhagic; herpes; high; higher; hsct; hsct patients; hsct recipients; human; immune; immunocompromised; immunosuppressive; important; incidence; infection; influenza; invasive; jirovecii; korea; leukemia; low; lrti; malignancies; management; marrow; months; mortality; neutropenia; non; onset; outcomes; pathogens; patients; pcp; period; phase; pneumocystis; pneumonia; positive; post; pre; prevention; progression; prophylaxis; range; rate; reactivation; recent; recipients; recovery; reduced; related; resistance; respiratory; retrospective; risk; rsv; single; solid; specific; spectrum; stem; stem cell; studies; study; table; therapy; time; transplant recipients; transplantation; treatment; use; vaccine; virus; voriconazole; year; zoster
    • versions: original; plain text
95. cord-348547-wmvqvbqi
    • author: Desmons, Aurore
    • title: Post-mortem diagnosis, of cytomegalovirus and varicella zoster virus co-infection by combined histology and tissue molecular biology, in a sudden unexplained infant death
    • date: 2013-10-31
    • words: 2319
    • flesch: 39
    • summary: Contribution of bacteriology and virology in sudden unexpected death in infancy Virological investigations in sudden unexpected death in infancy (SUDI) Virological analysis in the diagnosis of sudden children death: a medico-legal approach Microbiology in sudden infant death syndrome (SIDS) and other childhood deaths Identification and characterization of persistent human erythrovirus infection in blood donor samples Assessment of automated DNA extraction coupled with real-time PCR for measuring Epstein-Barr virus load in whole blood, peripheral mononuclear cells and plasma Real-time PCR for rapid diagnosis of entero-and rhinovirus infections using LightCycler Pring-Akerblom P. Rapid and quantitative detection of human adenovirus DNA by real-time PCR Development of a real-time polymerase chain reaction assay for the diagnosis of human herpesvirus-6 infection and application to bone marrow transplant patients Development of a real-time PCR procedure including an internal control for the measurement of HCMV viral load Sudden death in a toddler with laryngotracheitis caused by human parainfluenza virus-1 Sudden death in toddlers with viral meningitis, massive cerebral edema, and neurogenic pulmonary edema and hemorrhage: report of two cases Sudden death from human parainfluenza virus 2 Viruses and sudden infant death Detection of RNA viruses in sudden infant death (SID) Detection of respiratory syncytial virus using immunohistochemistry Detection and significance of adenoviruses in cases of sudden infant death Role of respiratory viral infection in SIDS: detection of viral nucleic acid by in situ hybridization Detection of human herpesvirus-6, Epstein-Barr virus and cytomegalovirus in formalin-fixed tissues from sudden infant death: a study with quantitative real-time PCR Cytomegalovirus-induced pneumonia and myocarditis in three cases of suspected sudden infant death syndrome (SIDS): diagnosis by immunohistochemical techniques and molecularpathologic methods PCR-based diagnosis of enterovirus and parvovirus B19 in paraffin-embedded heart tissue of children with suspected sudden infant death syndrome Coxsackie B3 myocarditis in 4 cases of suspected sudden infant death syndrome: diagnosis by immunohistochemical and molecular-pathologic investigations CMV-DNA detection in parenchymatous organs in cases of sudden infant death syndrome Cytomegalic inclusion disease of the salivary glands in sudden infant death syndrome Enterovirus in sudden unexpected deaths in infants Varicella-zoster virus replication site in internal organs of an otherwise healthy child with varicella and sudden death Paediatric varicella hospitalisations in France: a nationwide survey Neonatal antibody titers against varicella-zoster virus in relation to gestational age, birth weight, and maternal titer Transplacental transport of IgG antibodies to preterm infants: a review of the literature Varicellazoster virus gE escape mutant VZV-MSP exhibits an accelerated cell-to-cell spread phenotype in both infected cell cultures abd SCID-hu mice Antigenic variation of varicella zoster virus Fc receptor gE: loss of major B cell epitope in the ectodomain Potent immunosuppressive activities of cytomegalovirus-encoded interleukin-10 Role of virus-induced myocardial affections in sudden infant death syndrome: a prospective postmortem study Morphological quality and nucleic acid preservation in cytopathology Previous studies have demonstrated the major role of viral diseases in the pathogenesis of sudden unexpected infant death (SUID)
    • keywords: antibodies; case; cmv; combination; cytomegalovirus; days; death; detection; diagnosis; enterovirus; frozen; histology; human; immunohistochemistry; infant; infection; investigations; lungs; molecular; month; negative; nucleic; organs; paraffin; pcr; present; quantitative; real; respiratory; role; samples; sudden; suid; syndrome; time; tissues; varicella; viral; virological; virus; viruses; vzv; zoster
    • versions: original; plain text
96. cord-350807-qdq96723
    • author: Reckziegel, Maria
    • title: Viruses and atypical bacteria in the respiratory tract of immunocompromised and immunocompetent patients with airway infection
    • date: 2020-05-27
    • words: 4659
    • flesch: 37
    • summary: Seminars in respiratory and critical care medicine Respiratory syncytial virus: infection, detection, and new options for prevention and treatment Human metapneumovirus infection after allogeneic hematopoietic stem cell transplantation Laboratory diagnosis of infections in cancer patients: challenges and opportunities Impact of viral multiplex real-time PCR on management of respiratory tract infection: a retrospective cohort study Burden of human metapneumovirus infections in patients with cancer: risk factors and outcomes Infection in organ transplantation Antiviral therapy for respiratory viral infections in immunocompromised patients Respiratory viral infections in solid organ and hematopoietic stem cell transplantation Treatment of alpha and beta herpesvirus infections in solid organ transplant recipients Herpesvirus respiratory infections in immunocompromised patients: epidemiology, management, and outcomes Multiple viral infections after haploidentical hematopoietic stem cell transplantation in a child with acute lymphoblastic leukemia Virus-bacteria interactions: an emerging topic in human infection Viral-bacterial co-infections in the respiratory tract Bacterial pneumonia as an influenza complication An official American Thoracic Society research statement: noninfectious lung injury after hematopoietic stem cell transplantation: idiopathic pneumonia syndrome Metagenomic sequencing detects respiratory pathogens in hematopoietic cellular transplant patients Effective use of oral ribavirin for respiratory syncytial viral infections in allogeneic haematopoietic stem cell transplant recipients Consecutive yearly outbreaks of respiratory syncytial virus in a haemato-oncology ward and efficacy of infection control measures Parainfluenza 3 infections early after kidney or simultaneous pancreas-kidney transplantation In vivo persistence of human rhinoviruses in immunosuppressed patients The Virome of the human respiratory tract Generation of multipotent cell lines from a distinct population of male germ line stem cells Lack of p73 mutations and late occurrence of p73 allelic deletions in melanoma tissues and cell lines Establishment of PCR for the early diagnosis of herpes simplex encephalitis HSV-2 DNA persistence in astrocytes of the trigeminal root entry zone: double labeling by in situ PCR and immunohistochemistry Detection of varicella-zoster virus DNA by polymerase chain reaction in the cerebrospinal fluid of patients suffering from neurological complications associated with chicken pox or herpes zoster Evaluation of the polymerase chain reaction for diagnosis of herpes simplex virus encephalitis Monitoring of patients for cytomegalovirus after organ transplantation by centrifugation culture and PCR Laboratory diagnosis of herpes zoster Detection of herpes simplex virus (types 1 and 2) and human herpesvirus 6 DNA in human brain tissue by polymerase chain reaction Detection by PCR of HHV-6 and EBV DNA in blood and oropharynx of healthy adults and HIV-seropositives Comparison of a LightCyclerbased real-time PCR for quantitation of Epstein-Barr viral load in different clinical specimens with semiquantitative PCR Human parechovirus infections in Dutch children and the association between serotype and disease severity Prevalence, types, and RNA concentrations of human parechoviruses, including a sixth parechovirus type, in stool samples from patients with acute enteritis Screening respiratory samples for detection of human rhinoviruses (HRVs) and enteroviruses: comprehensive VP4-VP2 typing reveals high incidence and genetic diversity of HRV species C MEGA6: molecular evolutionary genetics analysis version 6.0 Viruses as sole causative agents of severe acute respiratory tract infections in children Seroprevalence of herpes simplex virus type 1 and type 2 in Thuringia Seroprevalence of varicella-zoster virus in the German population Evolution of EBV seroprevalence and primary infection age in a French hospital and a city laboratory network Cytomegalovirus seroprevalence among children and adolescents in Germany: data from the German health interview and examination survey for children and adolescents (KiGGS) Human herpesvirus 6 Herpesvirus infections in organ transplant recipients Clinical impact of HSV-1 detection in the lower respiratory tract from hospitalized adult patients Quantitative detection of Epstein-Barr virus in bronchoalveolar lavage from transplant and nontransplant patients Detection of herpesvirus EBV DNA in the lower respiratory tract of ICU patients: a marker of infection of the lower respiratory tract? Epstein-Barr virus-associated pneumonia in patients with posttransplant lymphoproliferative disease after hematopoietic stem cell transplantation The role of infection in interstitial lung diseases: a review Epstein-Barr virus-associated pneumonia and bronchiolitis obliterans syndrome in a lung transplant recipient Detection of Epstein-Barr virus DNA in peripheral blood is associated with the development of bronchiolitis obliterans syndrome after lung transplantation Chromosomally integrated human herpesvirus 6: questions and answers Human herpesvirus-6 infections in kidney, liver, lung, and heart transplantation: review Varicella pneumonia in adults Detection of respiratory viruses using a multiplex real-time PCR assay in Germany Respiratory syncytial virus infection-associated hospitalization in adults: a retrospective cohort study Human bocaviruses: possible etiologic role in respiratory infection Human bocavirus infection as a cause of severe acute respiratory tract infection in children Frequent detection of bocavirus DNA in German children with respiratory tract infections Current understanding of human enterovirus D68 Enterovirus and parechovirus infection in children: a brief overview A method to identify respiratory virus infections in clinical samples using next-generation sequencing Capnetz Study G (2015)
    • keywords: acute; addition; adults; age; authors; bacteria; barr; bov; c.p; cell; children; cmv; contribution; data; detection; development; diagnosis; disease; dna; ebv; epstein; equivalents; fig; genome; germany; hematopoietic; herpesviruses; hhv-6; higher; hmpv; hrv; human; immunocompetent; immunocompromised; immunosuppression; infections; influenza; kit; like; line; lung; m.p; observed; organ; pathogens; patients; pcr; pneumoniae; polymerase; positive; presence; prevalence; qiagen; reactivation; recipients; relevant; respiratory; rsv; rti; samples; solid; specimens; stem; study; supplementary; symptoms; syncytial; table; time; tract; transplant; transplantation; viral; viruses; years
    • versions: original; plain text
97. cord-354325-r73datur
    • author: Berger, Mitchell
    • title: Therapeutic Applications of Monoclonal Antibodies
    • date: 2002-07-31
    • words: 12352
    • flesch: 35
    • summary: Prevention of respiratory syncytial virus infections: indications for the use of palivizumab and update on the use of RSV-IGIV Respiratory syncytial virus (RSV) immune globulin and palivizumab for prevention of RSV infection Directed selection of recombinant human monoclonal antibodies to herpes simplex virus glycoproteins from phage display libraries Effective antibody therapy in herpes simplex virus ocular infection: characterization of recipient immune response Use of monoclonal antibody directed against herpes simplex virus glycoproteins to protect mice against acute virus-induced neurological disease Ability of monoclonal antibody to herpes simplex virus glycoprotein gB to promote healing of herpetic skin lesions in nude mice Protection against herpetic ocular disease by immunotherapy with monoclonal antibodies to herpes simplex virus glycoprotein Passive immunization with monoclonal antibodies against herpes simplex virus glycoproteins protects mice against herpetic ocular disease Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential Topically applied human recombinant monoclonal IgG 1 antibody and its Fab and F(ab')2 fragments protect mice from vaginal transmission of HSV-2 Epitopes involved in antibody-mediated protection from Ebola virus Isolation and characterization of human monoclonal antibodies to digoxin Drug-specific antibodies as antidotes for tricyclic antidepressant overdose Automated Immunosensing system for 3,5,6-trichloro-2-pyridinol application to surface water samples Exploiting antibody-based technologies to manage environmental pollution Pharmacokinetic mechanisms for obtaining high renal coelimination of phencyclidine and a monoclonal antiphencyclidine antigen-binding fragment of immunoglobulin G in the rat Prevention of paraquat toxicity in suspensions of alveolar type II cells by paraquatspecific antibodies Production and characterization of a monoclonal antibody against domoic acid and its application to enzyme immunoassay Antiphencyclidine monoclonal antibody therapy significantly changes phencyclidine concentrations in brain and other tissues in rats Pharmacodynamics of a monoclonal antiphencyclidine Fab with broad selectivity for phencyclidine-like drugs Antibodies as pharmacokinetic and metabolic modifiers of neurotoxicity Antibodies may treat overdoses, addiction Phencyclidine-specific Fab fragments alter phencyclidine disposition in dogs Crystal structure of monoclonal 6B5 Fab complexed with phencyclidine Disposition of a monoclonal anti-phencyclidine Fab fragment of immunoglobulin G in rats Drug-fighting drugs Reactive immunization A catalytic antibody against cocaine attenuates cocaine's cardiovascular effects in mice: a dose and time course analysis Natural and artificial enzymes against cocaine. The vectors will replicate in the COS cells and transiently express and secrete reshaped human antibodies.
    • keywords: acid; active; adcc; affinity; agents; amino; animals; antibodies; antibody; antibody fragments; antibody therapy; antigen; applications; asthma; bacteria; binding; blood; breast; cancer; cause; cells; center; chain; characterization; chimeric; clinical; cmv; cocaine; coding; complement; complexes; constant; cross; culture; cytomegalovirus; cytotoxic; development; different; difficult; digoxin; disease; display; disulfide; domain; dose; drug; effective; effector; effects; enzyme; epitopes; erythrocyte; evaluation; expression; fab; factor; fda; fragments; fusion; ganciclovir; generation; genes; glycoprotein; group; growth; hat; heavy; herpes; high; higher; host; hsv; human; human antibodies; human mabs; human monoclonal; human variable; hybridoma; idiotype; igg; immune; immunization; immunogenic; immunotherapy; infection; instance; light; lymphocytes; lymphoma; mabs; mice; model; molecules; monoclonal; monoclonal antibodies; mouse; murine; myeloma; natural; negative; neutralizing; new; patients; pcp; phage; phencyclidine; plants; points; potential; production; promising; protein; rate; rats; recent; receptor; recombinant; regions; renal; research; researchers; reshaped; response; risk; rodent; rsv; selection; sequences; simplex; single; site; specific; specificity; spleen; study; surface; system; target; testing; theory; therapeutic; therapy; time; tissues; tobacco; toxin; transgenic; transplant; treatment; trial; tumor; use; variable; variable regions; vectors; virus; vivo
    • versions: original; plain text
98. cord-354374-rtgjjglc
    • author: C.G. Pollok, Richard
    • title: Enteric viruses in HIV-related diarrhoea
    • date: 2000-12-01
    • words: 3491
    • flesch: 32
    • summary: CMV infection of the GI tract, in patients with AIDS have diminished greatly. The pathogenic role of CMV infection is well established.
    • keywords: adenovirus; aids; antiretroviral; association; cause; chronic; clinical; cmv; colitis; colleagues; common; culture; cytomegalovirus; development; diagnosis; diarrhoea; disease; dna; endoscopic; enteric; ganciclovir; group; haart; hiv; immune; immunodeficiency; infection; intestinal; introduction; levels; microscopy; opportunistic; oral; pathogens; patients; positive; randomized; response; retinitis; role; specific; stool; study; syndrome; therapy; tract; treatment; viraemia; viral; viruses
    • versions: original; plain text