# bib

id: cord-254224-123nwaxy
author: Sato, Kunihiko
title: Neutralizing Antibody to Calf Diarrhea Coronavirus in Various Animal Species in Japan
date: 2013-11-14
extension: .txt
mime: text/plain
words: 779
sentence: 26
flesch: 36
cache: cache/cord-254224-123nwaxy.txt
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summary:
  Coronavirus and gastroenteritis in foals Recovery and characterization of a coronavirus from military dogs with diarrhea Feline infectious peritonitis virus Replication of bovine coronavirus in cell line BEK-I culture Coronaviruses: a comparative review Neonatal calf diarrhea: propagation, attenuation and characteristics of a coronavirus-like agent Characteristics of a coronavirus (strain 67N) of pigs Morphologic and physical characteristics of feline infectious peritonitis virus and its growth in autochthonous peritoneal cell cultures Antigenic relationship of the feline infectious peritonitis virus to coronaviruses of other species Electron microscopy of coronavirus-like particles characteristic of turkey bluecomb disease Serological relation between calf diarrhea coronavirus and hemagglutinating encephalomyelitis virus Characterization of a calf diarrheal coronavirus In this paper we report on the presence of neutralizing antibodies against calf diarrhea coronavirus (6, 12) in serum specimens from various animal species.


id: cord-280518-2tl0mtb8
author: Xia, Jianhua
date: 2020-03-12
extension: .txt
mime: text/plain
words: 1370
sentence: 67
flesch: 53
cache: cache/cord-280518-2tl0mtb8.txt
txt: txt/cord-280518-2tl0mtb8.txt
title:
  Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS‐CoV‐2 infection

summary:
  In 2004, some researchers found that the tears of SARS patients tested positive for viral nucleic acid, some patients only showed positive results with tear samples, 8 and the chromosome of SARS-CoV-2 was 82% similar to that of SARS-CoV. 9 On 11 February 2020, the WHO officially named infection due to the virus as coronavirus disease 2019 (COVID- 19) 5 Study Group of the International Committee on Taxonomy of Viruses named 2019-nCoV severe acute respiratory syndrome-related coronavirus 2, or SARS-CoV-2.


id: cord-293166-gkzebyda
author: Hoz, Samer S.
date: 2020-11-03
extension: .txt
mime: text/plain
words: 1350
sentence: 51
flesch: 45
cache: cache/cord-293166-gkzebyda.txt
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title:
  Letter to the Editor: “Beyond Containment: Tracking the Impact of Coronavirus Disease 2019 (COVID-19) on Neurosurgery Services in Iraq”

summary:
  In addition, national public education plans for the de-stigmatization of the disease are needed, since many reports of transmission to hospital personnel have been traced back to patients who have denied their symptoms or exposure status. However, these measures are far from adequate and the hospital remains a full-house at all times, with at least 4 patients per hospital room, challenging the proper implementation of social distancing guidelines.


id: cord-024942-udhajlx2
author: Tang, Lei
title: Severe COVID-19 Pneumonia: Assessing Inflammation Burden with Volume-rendered Chest CT
date: 2020-03-06
extension: .txt
mime: text/plain
words: 226
sentence: 15
flesch: 42
cache: cache/cord-024942-udhajlx2.txt
txt: txt/cord-024942-udhajlx2.txt
summary:
  The patient was diagnosed with severe COVID-19 pneumonia. To order printed copies, contact reprints@rsna.org Severe COVID-19 Pneumonia:


id: cord-259949-ewcv8m06
author: Xiao, Shu‐Yuan
date: 2020-02-17
extension: .txt
mime: text/plain
words: 967
sentence: 37
flesch: 42
cache: cache/cord-259949-ewcv8m06.txt
txt: txt/cord-259949-ewcv8m06.txt
title:
  Evolving status of the 2019 novel coronavirus infection: Proposal of conventional serologic assays for disease diagnosis and infection monitoring

summary:
  Update on the epidemic of novel coronavirus (2019-nCoV) SARS and common viral infections Detection of specific antibodies to severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein for serodiagnosis of SARS coronavirus pneumonia F I G U R E 1 CT images of patients with novel coronavirus pneumonia.


id: cord-266989-n040i865
author: Ioannidis, John P. A.
title: Coronavirus disease 2019: The harms of exaggerated information and non‐evidence‐based measures
date: 2020-04-09
extension: .txt
mime: text/plain
words: 2574
sentence: 134
flesch: 48
cache: cache/cord-266989-n040i865.txt
txt: txt/cord-266989-n040i865.txt
summary:
  The fact that containment measures do seem to work, means that the basic reproduction number is probably in the lower bound of the 1.3-6.5 range, and can decrease below 1 with proper measures. The proportion of undetected infections is unknown but probably varies across countries and may be very large overall • Reported epidemic curves are largely affected by the change in availability of test kits and the willingness to test for the virus over time • Of the multiple measures adopted, a few have strong evidence, and many may have obvious harms • Panic shopping of masks and protective gear and excess hospital admissions may be highly detrimental to health systems without offering any concomitant benefit • Extreme measures such as lockdowns may have major impact on social life and the economy (and those also lives lost), and estimates of this impact are entirely speculative • Comparisons with and extrapolations from the 1918 influenza pandemic are precarious, if not outright misleading and harmful pandemic suggest that early adoption of social distancing measures was associated with lower peak death rates.


id: cord-289680-pjcskj4m
author: Piazza, Kelly Senters
title: Light in the midst of chaos: COVID-19 and female political representation()
date: 2020-09-02
extension: .txt
mime: text/plain
words: 3119
sentence: 101
flesch: 32
cache: cache/cord-289680-pjcskj4m.txt
txt: txt/cord-289680-pjcskj4m.txt
summary:
  Research on gender and politics shows that exceptional environments can activate stereotypes of women as honest, trustworthy, and competent lawmakers in public health and, in doing so, can generate increased public support for female political candidates. Such unique environments may promote female candidates either because they increase the demand for desirable qualities associated with women or because they focus voters' attention on issues that women are perceived to be especially competent in addressing.


id: cord-294651-iy0h2pyf
author: Nasrallah, Ali A.
date: 2020-06-08
extension: .txt
mime: text/plain
words: 3366
sentence: 155
flesch: 42
cache: cache/cord-294651-iy0h2pyf.txt
txt: txt/cord-294651-iy0h2pyf.txt
title:
  A large number of COVID-19 interventional clinical trials were registered soon after the pandemic onset: a descriptive analysis

summary:
  A major limitation of our study is that the pool of COVID-19 registered trials is rapidly growing, hence the data would need to be periodically updated. key: cord-294651-iy0h2pyf authors: Nasrallah, Ali A.; Farran, Sarah H.; Nasrallah, Zainab A.; Chahrour, Mohamad A.; Salhab, Hamza A.; Fares, Mohammad Y.; Khachfe, Hussein H.; Akl, Elie A. title: A large number of COVID-19 interventional clinical trials were registered soon after the pandemic onset: a descriptive analysis date: 2020-06-08 journal: J Clin Epidemiol DOI: 10.1016/j.jclinepi.2020.06.005 sha: doc_id: 294651 cord_uid: iy0h2pyf Abstract Background There is a pressing need for evidence-based interventions to address the devastating clinical and public health effects of the Coronavirus disease 2019 (COVID-19) pandemic.


id: cord-255603-quuju9h4
author: Kumar, Aishwarya
title: A review of modern technologies for tackling COVID-19 pandemic
date: 2020-05-07
extension: .txt
mime: text/plain
words: 3302
sentence: 148
flesch: 42
cache: cache/cord-255603-quuju9h4.txt
txt: txt/cord-255603-quuju9h4.txt
summary:
  COVID-Net an artificial intelligence application is created to analyze COVID-19 symptoms in chest x-rays utilizing information of different lung conditions and COVID-19 from patients [10] . In a diagnostic study, an AI platform was established using inception migration neural network for extracting COVID-19 symptoms using CT images, achieving 89.5% accuracy


id: cord-034351-5br4faov
author: Xu, Shuang-Fei
date: 2020-10-02
extension: .txt
mime: text/plain
words: 3454
sentence: 142
flesch: 46
cache: cache/cord-034351-5br4faov.txt
txt: txt/cord-034351-5br4faov.txt
title:
  Cross-Sectional Seroepidemiologic Study of Coronavirus Disease 2019 (COVID-19) among Close Contacts, Children, and Migrant Workers in Shanghai

summary:
  Participants must meet the following inclusion criteria: Close contacts: The definition of close contacts is based on Prevention and Control of Novel Coronavirus Pneumonia (6th edition), which refers to people who had unprotected close contact (within 1 meter) with a confirmed or suspect case within two days before illness onset, or with an asymptomatic infected person within two days before sampling [10] . Three categories of study participants will be recruited in the study as they are important for case finding in communities.


id: cord-274416-bmvazgj7
author: Trevisanuto, Daniele
date: 2020-04-24
extension: .txt
mime: text/plain
words: 3769
sentence: 178
flesch: 45
cache: cache/cord-274416-bmvazgj7.txt
txt: txt/cord-274416-bmvazgj7.txt
title:
  Neonatal Resuscitation Where the Mother Has a Suspected or Confirmed Novel Coronavirus (SARS-CoV-2) Infection: Suggestion for a Pragmatic Action Plan

summary:
  Lancet Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn A case report of neonatal COVID-19 infection in China Neonati ricoverati con infezione sospetta o accertata da SARS-CoV-2. Urgent questions that need to be addressed promptly include whether pregnant women who have confirmed COVID-19 infection are more likely to experience lifethreatening events, and whether SARS-CoV-2 could spread vertically and pose risks to the fetus and neonate [12, 13] .


id: cord-303523-m16vlv1q
author: Ogundokun, R. O.
title: MACHINE LEARNING PREDICTION FOR COVID 19 PANDEMIC IN INDIA
date: 2020-05-26
extension: .txt
mime: text/plain
words: 3894
sentence: 180
flesch: 44
cache: cache/cord-303523-m16vlv1q.txt
txt: txt/cord-303523-m16vlv1q.txt
summary:
  The results showed that COVID-19 disease can correctly be predicted. Figure of recorded COVID-19 crises as of January 2020 to April 2020 As a substitute for epidemiologic spread procedure, the study employed 3 aggregated methods SVR, NN, and LR to predict the instantaneous movement of the conveyance dynamics and generate the real-time predictions of COVID-19 disease transversely the metropolises of India.


id: cord-281754-auqh3vtr
title: EMERGING RESPIRATORY DISEASE - CORONAVIRUSES
date: 2017-09-12
extension: .txt
mime: text/plain
words: 3627
sentence: 182
flesch: 45
cache: cache/cord-281754-auqh3vtr.txt
txt: txt/cord-281754-auqh3vtr.txt
summary:
  By the end of 2003, according to the CDC report of WHO data, reports of SARS infections from 29 countries and regions revealed 8,096 persons with probable SARS resulting in 774 deathswith an estimated case fatality rate just below 10% (higher in elderly, infirm patients). SARS CoV


id: cord-292751-tk1oggi9
author: Hosseini, Elahe Seyed
date: 2020-09-24
extension: .txt
mime: text/plain
words: 3817
sentence: 170
flesch: 42
cache: cache/cord-292751-tk1oggi9.txt
txt: txt/cord-292751-tk1oggi9.txt
title:
  The novel coronavirus Disease-2019 (COVID-19): Mechanism of action, detection and recent therapeutic strategies

summary:
  The Lancet infectious diseases Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Coronaviruses-drug discovery and therapeutic options Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections Comparative effectiveness of combined favipiravir and oseltamivir therapy versus oseltamivir monotherapy in critically ill patients with influenza virus infection The Novel Chinese Coronavirus (2019-nCoV) Infections: challenges for fighting the storm Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses A randomized, controlled trial of Ebola virus disease therapeutics Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease Therapeutic options for the 2019 novel coronavirus (2019-nCoV). MedRxiv Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis Sex-based differences in susceptibility to severe acute respiratory syndrome coronavirus infection Sexual dimorphism in innate immunity An ultrasensitive, rapid, and portable coronavirus SARS-CoV-2 sequence detection method based on CRISPR-Cas12.


id: cord-297168-t6zf5k99
author: Brüssow, Harald
title: The Novel Coronavirus – A Snapshot of Current Knowledge
date: 2020-03-06
extension: .txt
mime: text/plain
words: 4151
sentence: 166
flesch: 45
cache: cache/cord-297168-t6zf5k99.txt
txt: txt/cord-297168-t6zf5k99.txt
summary:
  Therapeutics directed against immunopathological host responses might have a treatment value in view of the 'cytokine storm' seen in some patients with novel coronavirus infections. Vaccines against MERS and SARS are currently not available. Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients Outside Wuhan, China Protecting health-care workers from subclinical coronavirus infection Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study A new transmission route for the propagation of the SARS-CoV-2 coronavirus.


id: cord-264296-0x90yubt
author: Sawmya, Shashata
title: Analyzing hCov genome sequences: Applying Machine Intelligence and beyond
date: 2020-06-03
extension: .txt
mime: text/plain
words: 5017
sentence: 251
flesch: 56
cache: cache/cord-264296-0x90yubt.txt
txt: txt/cord-264296-0x90yubt.txt
summary:
  Thus, every resulting time-step represents a date (Tk for Cluster k) and contains the clusters of genome sequences of the countries/states. Notably, we do not consider any alignmentbased method since it is not computationally feasible for us to align thousands of viral sequences for analysis and clustering purposes [4] .


id: cord-297323-l3f12hg4
author: Amor, Sandra
date: 2020-09-26
extension: .txt
mime: text/plain
words: 4990
sentence: 151
flesch: 26
cache: cache/cord-297323-l3f12hg4.txt
txt: txt/cord-297323-l3f12hg4.txt
title:
  Innate immunity during SARS‐CoV‐2: evasion strategies and activation trigger hypoxia and vascular damage

summary:
  All rights reserved the Acute COVID-19 Cardiovascular Syndrome Neurological associations of COVID-19 The Proteins of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2 or n-COV19), the Cause of COVID-19 Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19 Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding 3D Models of glycosylated SARS-CoV-2 spike protein suggest challenges and opportunities for vaccine development Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy Neuropilin-1 is a host factor for SARS-CoV-2 infection Accessory proteins of SARS-CoV and other coronaviruses Extreme genomic CpG deficiency in SARS-CoV-2 and evasion of host antiviral defense Identification of Residues of SARS-CoV nsp1 That Differentially Affect Inhibition of Gene Expression and Antiviral Signaling Severe Acute Respiratory Syndrome Coronavirus Evades Antiviral Signaling: Role of nsp1 and Rational Design of an Attenuated Strain Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation Like many viruses, SARS‐CoV‐2 has evolved strategies to circumvent innate immune detection including low CpG levels in the genome, glycosylation to shield essential elements including the receptor binding domain, RNA shielding and generation of viral proteins that actively impede anti‐viral interferon responses.


id: cord-268939-ws74xprt
author: Ozoner, Baris
title: Neurosurgery Practice During Coronavirus Disease 2019 (COVID-19) Pandemic
date: 2020-05-28
extension: .txt
mime: text/plain
words: 5145
sentence: 273
flesch: 41
cache: cache/cord-268939-ws74xprt.txt
txt: txt/cord-268939-ws74xprt.txt
summary:
  Screening is crucial in all patients since the surgical outcome is highly mortal in COVID-19 patients. In this way, hub hospitals are available to manage neurosurgical emergencies, whereas spoke hospitals concentrate on COVID-19 patients.


id: cord-279363-4almssg6
author: Crespo, Roland Mojica
title: Pandemia COVID-19, la nueva emergencia sanitaria de preocupación internacional: una revisión
date: 2020-05-16
extension: .txt
mime: text/plain
words: 5186
sentence: 214
flesch: 44
cache: cache/cord-279363-4almssg6.txt
txt: txt/cord-279363-4almssg6.txt
summary:
  Estas estructuras están constituidas por complejos triméricos de la glicoproteína viral S (Spike) 5,14,15 . Concretamente la RNVE en su informe n°29 del día 7 de mayo enumera los principales síntomas presentados por el conjunto de la población española, hasta la fecha y a base de una muestra de 217,543 casos, de la siguiente manera: Entre estos hallazgos, es comúnmente observar la leucopenia y linfopenia, siendo esta última característica de COVID-19.


id: cord-268822-o86zpu92
author: Anser, Muhammad Khalid
date: 2020-08-18
extension: .txt
mime: text/plain
words: 5514
sentence: 198
flesch: 44
cache: cache/cord-268822-o86zpu92.txt
txt: txt/cord-268822-o86zpu92.txt
title:
  Communicable Diseases (Including COVID-19)—Induced Global Depression: Caused by Inadequate Healthcare Expenditures, Population Density, and Mass Panic

summary:
  Thus, the impact of COVID-19 in the given study is negatively impacting countries' economic growth that converts into a global depression. Thus, the impact of COVID-19 in the given study is negatively impacting countries' economic growth that converts into a global depression.


id: cord-282977-kmj8hj78
author: Babbar, S.
title: Battle with COVID-19 Under Partial to Zero Lockdowns in India
date: 2020-07-04
extension: .txt
mime: text/plain
words: 6078
sentence: 309
flesch: 61
cache: cache/cord-282977-kmj8hj78.txt
txt: txt/cord-282977-kmj8hj78.txt
summary:
  Medical researchers all over the world are busy experimenting right vaccine for the virus, academic researchers are making predictions based on machine learning and time series models and astrologers are forecasting the end of disease based on planetary position and more. The key motivation to integrate two methods for the predictive task is to use benefits of SEIR model by making its key parameters learn using historical data of confirmed cases under full and partial to zero lockdowns in India.


id: cord-267436-mivxm8oh
author: Groneberg, David A
title: Treatment and vaccines for severe acute respiratory syndrome
date: 2005-03-10
extension: .txt
mime: text/plain
words: 5918
sentence: 229
flesch: 36
cache: cache/cord-267436-mivxm8oh.txt
txt: txt/cord-267436-mivxm8oh.txt
summary:
  The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen A cluster of cases of severe acute respiratory syndrome in Hong Kong A major outbreak of severe acute respiratory syndrome in Hong Kong Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR China Severe acute respiratory syndromerelated coronavirus is inhibited by interferon-alpha Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus Severe acute respiratory syndrome-associated coronavirus in lung tissue Common adverse events associated with the use of ribavirin for severe acute respiratory syndrome in Canada Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Novel peptide inhibitors of angiotensin-converting enzyme 2 Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors Cloaked similarity between HIV-1 and SARS-CoV suggests an anti-SARS strategy Inhibiting severe acute respiratory syndrome-associated coronavirus by small interfering RNA Modulation of HIV-1 replication by RNA interference Interference of hepatitis C virus RNA replication by short interfering RNAs Short interfering RNA-directed inhibition of hepatitis B virus replication Silencing SARS-CoV spike protein expression in cultured cells by RNA interference Inhibition of SARS-associated coronavirus infection and replication by RNA interference Effect of glycyrrhizin, an active component of licorice roots, on HIV replication in cultures of peripheral blood mononuclear cells from HIV-seropositive patients Long-term treatment of chronic hepatitis C with glycyrrhizin [stronger neo-minophagen C (SNMC)] for preventing liver cirrhosis and hepatocellular carcinoma Lamivudine and glycyrrhizin for treatment of chemotherapy-induced hepatitis B virus (HBV) hepatitis in a chronic HBV carrier with non-Hodgkin lymphoma Induction of inducible nitric oxide synthase and proinflammatory cytokines expression by o,pЈ-DDT in macrophages Inhibition of SARS-CoV infection in vitro by S-nitroso-Nacetylpenicillamine, a nitric oxide donor compound Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness Role of nitric oxide in chronic allergen-induced airway cell proliferation and inflammation Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide Small molecules targeting severe acute respiratory syndrome human coronavirus Pro/con clinical debate: steroids are a key component in the treatment of SARS Lung pathology of fatal severe acute respiratory syndrome Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area Severe acute respiratory syndrome (SARS) in Singapore: clinical features of index patient and initial contacts High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome Fatal aspergillosis in a patient with SARS who was treated with corticosteroids SARS: prognosis, outcome and sequelae Avascular necrosis of bone in severe acute respiratory syndrome Role of interferons in the treatment of severe acute respiratory syndrome Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs Interferon-beta 1a and SARS coronavirus replication Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques How the SARS vaccine effort can learn from HIVspeeding towards the future, learning from the past Treatment of severe acute respiratory syndrome with convalescent plasma Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets Caution urged on SARS vaccines A review of feline infectious peritonitis virus: molecular biology, immunopathogenesis, clinical aspects, and vaccination Effects of a SARS-associated coronavirus vaccine in monkeys Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice Nucleic acid vaccines: an overview A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice Generation and characterization of DNA vaccines targeting the nucleocapsid protein of severe acute respiratory syndrome coronavirus Induction of SARS-nucleoproteinspecific immune response by use of DNA vaccine SARS-one year later Seasonality of infectious diseases and severe acute respiratory syndrome-what we don't know can hurt us Clinical trials and novel pathogens: lessons learned from SARS Preparing to prevent severe acute respiratory syndrome and other respiratory infections Collateral damage: the unforeseen effects of emergency outbreak policies Support from the Deutsche Atemwegsliga and the German Research Foundation (DFG GR2014/2-1) to DAG is gratefully acknowledged. 13, 14 Evidence suggests that SARS coronavirus originated from SARS-like viruses in animals in the southern Chinese province of Guangdong; the most frequently implicated animal is the Himalayan palm civet, an animal found in food markets and eaten as a delicacy.


id: cord-276951-di5n4wyd
author: Venturini, Elisabetta
date: 2020-05-19
extension: .txt
mime: text/plain
words: 614
sentence: 26
flesch: 42
cache: cache/cord-276951-di5n4wyd.txt
txt: txt/cord-276951-di5n4wyd.txt
title:
  Severe neutropenia in infants with severe acute respiratory syndrome caused by the novel coronavirus 2019 infection

summary:
  Novel coronavirus (COVID-19) situation Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China Laboratory abnormalities in children with novel coronavirus disease 2019 Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating personto-person transmission: a study of a family cluster A case series of children with 2019 novel coronavirus infection: clinical and epidemiological features Analysis of CT features of 15 children with 2019 novel coronavirus infection A well infant with coronavirus disease 2019 (COVID-19) with high viral load Clinical analysis of 31 cases of 2019 novel coronavirus infection in children from six provinces (autonomous region) of northern China Novel coronavirus infection in a three-month-old baby China's first neonatal coronavirus pneumonia Twin girls infected with SARS-CoV-2 A case of children with 2019 novel Coronavirus Infection Chinese Pediatric Novel Coronavirus Study Team. key: cord-276951-di5n4wyd authors: Venturini, Elisabetta; Palmas, Giordano; Montagnani, Carlotta; Chiappini, Elena; Citera, Francesco; Astorino, Valeria; Trapani, Sandra; Galli, Luisa title: Severe neutropenia in infants with severe acute respiratory syndrome caused by the novel coronavirus 2019 infection date: 2020-05-19 journal: J Pediatr DOI: 10.1016/j.jpeds.2020.04.051 sha: doc_id: 276951 cord_uid: di5n4wyd nan To the Editor: Infection with severe acute respiratory syndrome caused by the novel coronavirus 2019 (SARS-CoV-2) and resulting coronavirus disease 2019 (COVID-19) is a global pandemic.


id: cord-299093-zp07aqpm
author: Harrison, Andrew G.
title: Mechanisms of SARS-CoV-2 transmission and pathogenesis
date: 2020-10-14
extension: .txt
mime: text/plain
words: 6401
sentence: 220
flesch: 34
cache: cache/cord-299093-zp07aqpm.txt
txt: txt/cord-299093-zp07aqpm.txt
summary:
  A first step in understanding SARS pathogenesis A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues Atlas of ACE2 gene expression in mammals reveals novel insights in transmission of SARS-CoV-2 A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry Single-cell RNA expression profiling of ACE2, the receptor of SARS-CoV-2 Angiotensin-converting enzyme 2 protects from severe acute lung failure Endocytosis of the receptor-binding domain of SARS-CoV spike protein together with virus receptor ACE2 Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract Furin cleavage of the SARS coronavirus spike glycoprotein enhances cell-cell fusion but does not affect virion entry SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa Virological assessment of hospitalized patients with COVID-2019 Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes High Prevalence of Concurrent Gastrointestinal Manifestations in Patients with SARS-CoV-2: Early Experience from California Evidence for Gastrointestinal Infection of SARS-CoV-2 Enteric involvement of severe acute respiratory syndromeassociated coronavirus infection Evidence of Airborne Transmission of the Severe Acute Respiratory Syndrome Virus Transmission of SARS and MERS coronaviruses and influenza virus in healthcare settings: the possible role of dry surface contamination Role of air distribution in SARS transmission during the largest nosocomial outbreak in Hong Kong Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients Viral load of SARS-CoV-2 in clinical samples Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia at admission in Wuhan Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany The clinical feature of silent infections of novel coronavirus infection (COVID-19) in Wenzhou Possible modes of transmission of Novel coronavirus SARS-CoV-2: a review SARS: experience at Prince of Wales Hospital, Hong Kong Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1 Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19) Clinical Characteristics and Outcomes of Hospitalized and Critically Ill Children and Adolescents with Coronavirus Disease 2019 (COVID-19) at a Tertiary Care Medical Center The Twilight of Immunity: Emerging Concepts in Aging of the Immune System Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2 Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Clinical characteristics of COVID-19 in 104 people with SARS-CoV-2 infection on the Diamond Princess cruise ship: a retrospective analysis Clinical characteristics of 82 cases of death from COVID-19 Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses Cellular Immune Responses to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection in Senescent BALB/c Mice: CD4+ T Cells Are Important in Control of SARS-CoV Infection Evasion by Stealth: Inefficient Immune Activation Underlies Poor T Cell Response and Severe Disease in SARS-CoV-Infected Mice Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 Dysregulation of immune response in patients with COVID-19 in Wuhan, China Imbalanced host response to SARS-CoV-2 drives development of COVID-19 SARS-CoV-2 activates lung epithelia cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients by single-cell sequencing The clinical pathology of severe acute respiratory syndrome (SARS): a report from China Lung pathology of fatal severe acute respiratory syndrome Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China Cytokine release syndrome in severe COVID-19 Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology C-reactive protein: Ligands, receptors and role in inflammation Neutrophil extracellular traps in COVID-19 Endothelial cell infection and endotheliitis in COVID-19 Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients Regulation of IRF-3 dependent innate immunity by the Papainlike protease domain of the SARS coronavirus Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease Ubiquitin-Like Domain and Catalytic Domain Regulate Antagonism of IRF3 and NF-κB Signaling Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling Activation and evasion of type I interferon responses by SARS-CoV-2 Severe acute respiratory syndrome coronavirus protein nsp1 is a novel eukaryotic translation inhibitor that represses multiple steps of translation initiation Middle East Respiratory Syndrome Coronavirus nsp1 Inhibits Host Gene Expression by Selectively Targeting mRNAs Transcribed in the Nucleus while Sparing mRNAs of Cytoplasmic Origin Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2 Evasion of type- Indeed, similar inflammatory milieux have been associated with severe lung pathology in SARS patients, along with the notable 'cytokine storm' that can present in critically ill COVID-19 patients [83, 84]


id: cord-254446-yxqbe1dj
author: Ren, Yunzhao R.
title: A Comprehensive Updated Review on SARS‐CoV‐2 and COVID‐19
date: 2020-05-29
extension: .txt
mime: text/plain
words: 6750
sentence: 205
flesch: 32
cache: cache/cord-254446-yxqbe1dj.txt
txt: txt/cord-254446-yxqbe1dj.txt
summary:
  One study reported that IFN-γ, TNF-α, IL-1β, and IL-8 plasma concentrations in COVID-19 patients were significantly higher compared to results from four healthy In addition to the consistent trend of lower lymphocyte counts observed in severe cases of COVID-19 (Table 3 ) from different studies, total T cells, CD4 + T cells, and CD8 + T cells also were significantly lower in severe/critical COVID-19 cases than in non-severe cases 124, 127, 128 . They also found that CD8 + T cells in COVID-19 patients exhibit many aspects of exhaustion and reduced function, such as Once in the cell, the virus is not killed or neutralized; instead, it may continue to replicate, and/or stimulate or kill the target cells, causing more inflammation and damage.


id: cord-139097-deuvq0wf
author: Sahasranaman, Anand
title: Network structure of COVID-19 spread and the lacuna in India's testing strategy
date: 2020-03-21
extension: .txt
mime: text/plain
words: 1827
sentence: 57
flesch: 43
cache: cache/cord-139097-deuvq0wf.txt
txt: txt/cord-139097-deuvq0wf.txt
summary:
  One COVID-19 positive infects 1.7 in India, lower than in hot zones India needs a more aggressive testing regimen for coronavirus: Experts Public-health experts raise concerns about India's restricted testing for COVID-19 Is India testing enough for coronavirus cases? Will know if India is going through community transmission of Covid-19: ICMR Worldometers Strategy of COVID19 testing in India Impact of non-pharmaceutical interventions (NPIs) to reduce COVID-19 mortality and healthcare demand Because case numbers in India are still close to 200, we find that newspapers are still tracking individual case histories; and we use these newspaper reports and Wikipedia to construct the data set on individual transmission


id: cord-266260-t02jngq0
author: Ramshaw, Rebecca E.
title: A database of geopositioned Middle East Respiratory Syndrome Coronavirus occurrences
date: 2019-12-13
extension: .txt
mime: text/plain
words: 7243
sentence: 243
flesch: 30
cache: cache/cord-266260-t02jngq0.txt
txt: txt/cord-266260-t02jngq0.txt
summary:
  Vector Borne Zoonotic Dis Arabia: an index case investigation Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Stillbirth During Infection With Middle East Respiratory Syndrome Coronavirus Antibodies against MERS Coronavirus in Dromedary Camels MERS-CoV Antibodies in Humans, Africa No Serologic Evidence of Middle East Respiratory Syndrome Coronavirus Infection Among Camel Farmers Exposed to Highly Seropositive Camel Herds: A Household Linked Study Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County Occurrence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) across the Gulf Corporation Council countries: Four years update Emergence of MERS-CoV in the Middle East: origins, transmission, treatment, and perspectives Laboratory-confirmed case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in Malaysia: preparedness and response Dromedary camels in northern Mali have high seropositivity to MERS-CoV Middle East respiratory syndrome coronavirus (MERS-CoV) infections in two returning travellers in the Netherlands Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria Lack of serological evidence of Middle East respiratory syndrome coronavirus infection in virus exposed camel abattoir workers in Nigeria Asymptomatic MERS-CoV Infection in Humans Possibly Linked to Infected Dromedaries Imported from Oman to United Arab Emirates Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels The Middle East Respiratory Syndrome Coronavirus (MERS-COV) Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE Imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection from Oman to Thailand Serologic Evidence for MERS-CoV Infection in Dromedary Camels Contact tracing the first Middle East respiratory syndrome case in the Philippines Effectiveness of the Middle East respiratory syndrome-coronavirus protocol in enhancing the function of an Emergency Department in Qatar High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases Isolation of MERS coronavirus from a dromedary camel MERS-CoV Infection of Alpaca in a Region Where MERS-CoV is Endemic Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels Occupational Exposure to Dromedaries and Risk for MERS-CoV Infection Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Infection in Camel Workers in Qatar During 2013-2014: A Case-Control Study MERS-CoV outbreak in Jeddah-a link to health care facilities A case of long-term excretion and subclinical infection with Middle East respiratory syndrome coronavirus in a healthcare worker A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other Causes A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case Acute Management and Long-Term Survival Among Subjects With Severe Middle East Respiratory Syndrome Coronavirus Pneumonia and ARDS Acute Middle East Respiratory Syndrome Coronavirus: Temporal Lung Changes Observed on the Chest Radiographs of 55 Patients Acute myocarditis associated with novel Middle east respiratory syndrome coronavirus An outbreak of Middle East Respiratory Syndrome (MERS) due to coronavirus in Al-Ahssa Region, Saudi Arabia Antibody Response and Disease Severity in Healthcare Worker MERS Survivors Brief Report: Family Cluster of Middle East Respiratory Syndrome Coronavirus Infections Characteristics and Outcomes of Middle East Respiratory Syndrome Coronavirus Patients Admitted to an Intensive Care Unit in Jeddah, Saudi Arabia Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a singlecenter experience in Saudi Arabia Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia Descriptive epidemiology and characteristics of confirmed cases of Middle East respiratory syndrome coronavirus infection in the Makkah Region of Saudi Arabia Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Evidence for camel-to-human transmission of MERS coronavirus Exposures among MERS Case-Patients First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities Hospital outbreak of Middle East respiratory syndrome coronavirus Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Identified Transmission Dynamics of Middle East Respiratory Syndrome Coronavirus Infection During an Outbreak: Implications of an Overcrowded Emergency Department Impact of Middle East Respiratory Syndrome coronavirus (MERS-CoV) on pregnancy and perinatal outcome Lack of middle East respiratory syndrome coronavirus transmission from infected camels Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study Spread, circulation, and evolution of the Middle East A cluster analysis with implications for global management of suspected cases Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: Demographic, clinical and survival data Middle East respiratory syndrome coronavirus in children Middle East Respiratory Syndrome Coronavirus Infection During Pregnancy: A Report of 5 Cases From Saudi Arabia Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Molecular Epidemiology of Hospital Outbreak of Middle East Respiratory Syndrome Notes from the Field: Nosocomial Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital-Riyadh, Saudi Arabia Outbreak of Middle East Respiratory Syndrome at Tertiary Care Hospital Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, crosssectional, serological study Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients Report of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection in Four Patients with Hematological Malignancies Treated at King Fahad Medical City Risk Factors for Middle East Respiratory Syndrome Coronavirus Infection among Healthcare Personnel Spontaneous intracranial hemorrhage in a patient with Middle East respiratory syndrome corona virus Successful recovery of MERS CoV pneumonia in a patient with acquired immunodeficiency syndrome: a case report Surveillance and Testing for Middle East Respiratory Syndrome Coronavirus, Saudi Arabia The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study The first case of the 2015 Korean Middle East Respiratory Syndrome outbreak Travel-related MERS-CoV cases: an assessment of exposures and risk factors in a group of Dutch travellers returning from the Kingdom of Saudi Arabia Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Middle East respiratory syndrome coronavirus transmission among health care workers: Implication for infection control Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection -clinicopathological and ultrastructural study The calm before the storm: clinical observations of Middle East respiratory syndrome (MERS) patients The prevalence of Middle East respiratory Syndrome coronavirus (MERS-CoV) infection in livestock and temporal relation to locations and seasons Assessing the Detection of Middle East Respiratory Syndrome Coronavirus IgG in Suspected and Proven Cases of Middle East Respiratory Syndrome Coronavirus Infection Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia A cohort-study of patients suspected for MERS-CoV in a referral hospital in Saudi Arabia Conveyance Contact Investigation for Imported Middle East Respiratory Syndrome Cases Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses Outbreak of Middle East Respiratory Syndrome-Coronavirus Causes


id: cord-278325-ykcd7d59
author: Cheung, Carmen Ka Man
title: Coronavirus Disease 2019 (COVID-19): A Haematologist's Perspective
date: 2020-07-28
extension: .txt
mime: text/plain
words: 7682
sentence: 312
flesch: 35
cache: cache/cord-278325-ykcd7d59.txt
txt: txt/cord-278325-ykcd7d59.txt
summary:
  Thrombocytopenia, coagulation abnormalities, and disseminated intravascular coagulation were observed in COVID-19 patients, especially those with critical illness and non-survivors. [45] evaluated lymphocyte subsets in 103 patients, which revealed that CD3+, CD4+, and CD8+ T cells and NK cells were significantly decreased in COVID-19 patients with a more severe decrease in CD8+ T cells compared with CD4+ T cells.


id: cord-300170-s2qthxx4
author: Aven, Terje
date: 2020-10-15
extension: .txt
mime: text/plain
words: 8228
sentence: 298
flesch: 43
cache: cache/cord-300170-s2qthxx4.txt
txt: txt/cord-300170-s2qthxx4.txt
title:
  Globalization and global risk: How risk analysis needs to be enhanced to be effective in confronting current threats

summary:
  Disaster risk management seeks to identify and adopt adequate measures of prevention, mitigation, preparedness, emergency response and recovery (Pettit and Beresford 2005) . Various studies have shown that risk management of disasters can save lives and offer relief to those hit by the disaster (Pettit and Beresford 2005, Akgün et al 2015) .


id: cord-104420-b67xpq12
author: Mungmunpuntipantip, Rujittika
title: Frequency of diarrhea in novel coronavirus 2019 infection
date: 2020
extension: .txt
mime: text/plain
words: 277
sentence: 15
flesch: 48
cache: cache/cord-104420-b67xpq12.txt
txt: txt/cord-104420-b67xpq12.txt
summary:
  Emerging new coronavirus infection in Wuhan, China: situation in early 2020 Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical features of patients infected with 2019 novel coronavirus in Wuhan Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia Wiwanitkit V Diarrhoea as a presentation of bird flu infection: a summary on its correlation to outcome in Thai cases key: cord-104420-b67xpq12 authors: Mungmunpuntipantip, Rujittika; Wiwanitkit, Viroj title: Frequency of diarrhea in novel coronavirus 2019 infection date: 2020 journal:


id: cord-263672-iuo7ukaz
author: Engström, Gustav
title: What Policies Address Both the Coronavirus Crisis and the Climate Crisis?
date: 2020-07-31
extension: .txt
mime: text/plain
words: 8379
sentence: 376
flesch: 51
cache: cache/cord-263672-iuo7ukaz.txt
txt: txt/cord-263672-iuo7ukaz.txt
summary:
  We show that, among climate policies, labor-intensive green infrastructure projects, planting trees, and in particular pricing carbon coupled with reduced labor taxation boost economic recovery. Yet, for climate policies to have a chance of implementation at this moment, they cannot be at odds with addressing the current crisis.


id: cord-257824-qz6yxuph
author: Fuertes, Víctor
title: Current impact of Covid-19 pandemic on Spanish plastic surgery departments: a multi-center report
date: 2020-05-19
extension: .txt
mime: text/plain
words: 3488
sentence: 171
flesch: 51
cache: cache/cord-257824-qz6yxuph.txt
txt: txt/cord-257824-qz6yxuph.txt
summary:
  In two of the centers we have contacted, the staff has been properly trained on the medical management of Covid-19 patients. key: cord-257824-qz6yxuph authors: Fuertes, Víctor; Monclús, Enrique; Agulló, Alberto title: Current impact of Covid-19 pandemic on Spanish plastic surgery departments: a multi-center report date: 2020-05-19 journal: Eur J Plast Surg DOI: 10.1007/s00238-020-01686-0 sha: doc_id: 257824 cord_uid: qz6yxuph BACKGROUND: After its initial description in China, Covid-19 is hitting nations across the world, with Spain as the third country in number of deaths, after the USA and Italy.


id: cord-255284-ffh1jl40
author: Guery, B
title: Syndrome respiratoire aigu sévère
date: 2003-06-30
extension: .txt
mime: text/plain
words: 2811
sentence: 155
flesch: 57
cache: cache/cord-255284-ffh1jl40.txt
txt: txt/cord-255284-ffh1jl40.txt
summary:
  Cette hypothèse était étayée par la survenue de cas, mortels, de grippe aviaire à Hong Kong le 17 février. De novembre 2002 à février 2003, dans la province de Guangdong (sud de la Chine), 305 cas de pneumonies étaient signalés.


id: cord-004992-tvpo1kxb
author: Russell, R. G.
title: Coronavirus-like particles andCampylobacter in marmosets with diarrhea and colitis
date: 1985
extension: .txt
mime: text/plain
words: 2506
sentence: 107
flesch: 41
cache: cache/cord-004992-tvpo1kxb.txt
txt: txt/cord-004992-tvpo1kxb.txt
summary:
  Whereas no attempt has yet been made to react marmoset serum with the coronavirus-like particles observed in marmoset feces, marmoset serum was used to identify serological reactivity to the bovine enteric coronavirus and to the porcine tranmissible gastroenteritis coronavirus, each a representative of the two antigenic subfamilies of mammalian coronaviruses (12) . (2) Serum from a variety of colony animals should be used to attempt precipitation of viral particles by immune electron microscopy (10) .


id: cord-294677-l1b4mw9d
author: Prashantha, C.N.
date: 2020-10-13
extension: .txt
mime: text/plain
words: 2414
sentence: 95
flesch: 39
cache: cache/cord-294677-l1b4mw9d.txt
txt: txt/cord-294677-l1b4mw9d.txt
title:
  Molecular screening of antimalarial, antiviral, anti-inflammatory and HIV protease inhibitors against spike glycoprotein of Coronavirus

summary:
  SAVES is used to understand the complexity of protein structure based on atom-to-atom interaction of Ψ versus Φ conformational angels of 3D macromolecule measures the torsion angels of Cα (ideal) -N-Cβ (obs) and the results were represented in Ramachandran Plot. Prediction of protein structure is important in molecular docking, using I-TASSER to build three dimensional protein structure and used for homology modeling using SwissPDBViewer (SPDBV) software.


id: cord-268483-joiajgs4
author: Shah, Vibhuti Kumar
title: Overview of Immune Response During SARS-CoV-2 Infection: Lessons From the Past
date: 2020-08-07
extension: .txt
mime: text/plain
words: 10674
sentence: 311
flesch: 31
cache: cache/cord-268483-joiajgs4.txt
txt: txt/cord-268483-joiajgs4.txt
summary:
  A randomized trial of hydroxychloroquine as postexposure prophylaxis for covid-19 Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial Cinanserin is an inhibitor of the 3c-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro Inhibition of SARS-CoV 3CL protease by flavonoids Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2 Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia Treatment with convalescent plasma for influenza A (H5N1) infection The convalescent sera option for containing COVID-19 Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19 Effectiveness of convalescent plasma therapy in severe COVID-19 patients Use of convalescent plasma therapy in SARS patients in Hong Kong Available online at SARS vaccines: where are we? Neutralizing antibody against severe acute respiratory syndrome (SARS)-coronavirus spike is highly effective for the protection of mice in the murine SARS model SARS corona virus peptides recognized by antibodies in the sera of convalescent cases Severe acute respiratory syndrome (SARS) coronavirus: application of monoclonal antibodies and development of an effective vaccine Subunit vaccines against emerging pathogenic human coronaviruses Development of an inactivated vaccine candidate for SARS-CoV-2 ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus Effects of toll-like receptor stimulation on eosinophilic infiltration in lungs of BALB/c mice immunized with UV-inactivated severe acute respiratory syndrome-related coronavirus vaccine Neutralizing antibodies against SARS-CoV-2 and other human coronaviruses Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody Detection of SARS-CoV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals A human monoclonal antibody blocking SARS-CoV-2 infection Identification of human single-domain antibodies against SARS-CoV-2 Microneedle array delivered recombinant coronavirus vaccines: immunogenicity and rapid translational development SARS-CoV-2 vaccines: status report Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies Mast cells contribute to coronavirus-induced inflammation: new anti-inflammatory strategy Clinical features of patients infected with 2019 novel coronavirus in Wuhan A phase 3, single-arm, prospective study of remestemcel-l, ex vivo culture-expanded adult human mesenchymal stromal cells for the treatment of pediatric patients who failed to respond to steroid treatment for acute graft-versus-host disease Remestemcel-L: Human mesenchymal stem cells as an emerging therapy for Crohn's disease Transplantation of ACE2-mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia (2020) Immune responses in COVID-19 and potential vaccines: lessons learned from SARS and MERS epidemic People Who Are at Higher Risk for Severe Illness | Coronavirus | COVID-19 Severe acute respiratory syndrome-associated coronavirus in lung tissue Multiple organ infection and the pathogenesis of SARS SARS-CoV-2 Infection in Children Vulnerability of children with COVID-19 infection and ACE2 profiles in lungs Possible causes for decreased susceptibility of children to coronavirus Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus Characteristics and outcomes of children with coronavirus disease 2019 (COVID-19) infection admitted to US and canadian pediatric intensive care units Outbreak of Kawasaki disease in children during COVID-19 pandemic: a prospective observational Features of COVID-19 post-infectious cytokine release syndrome in children presenting to the emergency department Links between innate and adaptive immunity via type I interferon Interferon and cytokine responses to SARScoronavirus infection SARS-CoV regulates immune function-related gene expression in human monocytic cells Profiles of antibody responses against severe acute respiratory syndrome coronavirus recombinant proteins and their potential use as diagnostic markers Early detection of antibodies against various structural proteins of the SARSassociated coronavirus in SARS patients Serological assays for emerging coronaviruses : challenges and pitfalls Profile of specific antibodies to the SARS-associated coronavirus T cell responses to whole SARS coronavirus in humans Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2 : an observational cohort study Profiling early humoral response to diagnose novel coronavirus disease (COVID-19) Viral kinetics and antibody responses in patients with COVID-19 Protective humoral immunity in SARS-CoV-2 infected pediatric patients The potential danger of suboptimal antibody responses in COVID-19 Medical countermeasures analysis of 2019-nCoV and vaccine risks for antibody-dependent enhancement (ADE) Antibody-dependent enhancement of SARS coronavirus infection and its role in the pathogenesis of SARS Molecular mechanism for antibody-dependent enhancement of coronavirus entry Avoiding pitfalls in the pursuit of a COVID-19 vaccine Novel immunodominant peptide presentation strategy: a featured HLA-A * 2402-restricted cytotoxic t-lymphocyte epitope stabilized by intrachain hydrogen bonds from severe acute respiratory syndrome coronavirus nucleocapsid protein Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population Epidemiological and genetic correlates of severe acute respiratory syndrome coronavirus infection in the hospital with the highest nosocomial infection rate in Taiwan in 2003 Humanleukocyte antigen class


id: cord-289588-n61gz7pi
author: Samudrala, Pavan Kumar
title: Virology, pathogenesis, diagnosis and in-line treatment of COVID-19
date: 2020-07-17
extension: .txt
mime: text/plain
words: 3903
sentence: 130
flesch: 41
cache: cache/cord-289588-n61gz7pi.txt
txt: txt/cord-289588-n61gz7pi.txt
summary:
  The Journal 849 of hospital infection Nsp3 of coronaviruses: Structures and functions of a 851 large multi-domain protein Functional assessment of cell entry and receptor 853 usage for SARS-CoV-2 and other lineage B betacoronaviruses Structure of SARS coronavirus spike 856 receptor-binding domain complexed with receptor Molecular immune pathogenesis and 862 diagnosis of COVID-19 Development and Clinical Application of 866 A Rapid IgM-IgG Combined Antibody Test for SARS-CoV-2 Infection Diagnosis Potential preanalytical and analytical 869 vulnerabilities in the laboratory diagnosis of coronavirus disease 2019 (COVID-19) Receptor usage and cell entry of porcine epidemic diarrhea coronavirus Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting 876 SARS-CoV-2 infection in vitro Overlapping and discrete aspects of the pathology and pathogenesis of the 879 emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV COVID-19 vaccines: knowing the unknown Neurological Manifestations of Hospitalized Patients with China: a retrospective case series study Coronavirus (COVID-19): managing stress and anxiety Trypsin Treatment Unlocks Barrier for Zoonotic Bat This The clinical symptoms of COVID-19 infection can be seen after 5 to 6 days of incubation 272 which mainly differs from age and immune system of the person.


id: cord-031113-moekkw2x
author: Grace, Sara
title: Policing Social Distancing: Gaining and Maintaining Compliance in the Age of Coronavirus
date: 2020-07-12
extension: .txt
mime: text/plain
words: 11052
sentence: 422
flesch: 47
cache: cache/cord-031113-moekkw2x.txt
txt: txt/cord-031113-moekkw2x.txt
summary:
  This tension between PNDs on the one hand, providing an awareness of the possibility of being punished, whilst on the other, not necessarily affecting behaviour was highlighted in Interview 6 (on-the-spot, s5 PND for public urination, paid): I haven't done it again, I er, that's a lie [sounds incredulous, as though he is surprised at himself] I have done it again, I'm just really careful to look out for police officers beforehand . . Whether this will promote future cooperation with the police and long-term compliance with the law in general-as seen in other police legitimacy research (Reisig et al., 2007)


id: cord-026937-92836tr1
author: Benjamin, Elliot
title: Progressive Politics and Humanistic Psychology in the Trump/Coronavirus Era
date: 2020-06-15
extension: .txt
mime: text/plain
words: 4721
sentence: 149
flesch: 42
cache: cache/cord-026937-92836tr1.txt
txt: txt/cord-026937-92836tr1.txt
summary:
  And much of the answer to this question is related to my involvement with the grass roots progressive politics Resisting Trump Indivisible movement, 3 which like everything else in these Coronavirus times, has currently transformed into virtual connections. In the concluding section of one of my articles (Benjamin, 2019) , I summarized my view that many of the statements and policies of United States President Donald Trump are completely antithetical to the basic premises of humanistic psychology that involve engaging in genuine and empathic relationships with people: Under the current dangerous leadership and rhetoric of US President Donald Trump, the destructive effects on the mental health of much of our country's population are becoming increasingly apparent.


id: cord-303917-2tu707ng
author: Zhang, Lei
title: Potential interventions for novel coronavirus in China: A systematic review
date: 2020-03-03
extension: .txt
mime: text/plain
words: 5438
sentence: 219
flesch: 36
cache: cache/cord-303917-2tu707ng.txt
txt: txt/cord-303917-2tu707ng.txt
summary:
  The effect of ascorbic acid on infection chick-embryo ciliated tracheal organ cultures by coronavirus Nutrients and their role in host resistance to infection Vitamin C intake and susceptibility to pneumonia Vitamin D insufficiency among free-living healthy young adults Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease Acute phase response elicited by experimental bovine diarrhea virus (BVDV) infection is associated with decreased vitamin D and E status of vitamin-replete preruminant calves Vitamin E metabolic effects and genetic variants: a challenge for precision nutrition in obesity and associated disturbances Vitamin E deficiency intensifies the myocardial injury of coxsackievirus B3 infection of mice Increased virulence of coxsackievirus B3 in mice due to vitamin E or selenium deficiency Macrophage-derived extracellular vesicles induce long-lasting immunity against hepatitis C virus which is blunted by polyunsaturated fatty acids Plasma fatty acid levels in patients with acquired immune deficiency syndrome and in controls The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza Anti-HCV activities of selective polyunsaturated fatty acids Selenium and human health Micronutrients and host resistance to viral infection Review: micronutrient selenium deficiency influences evolution of some viral infectious diseases Selenium deficiency increases the pathology of an influenza virus infection Rapid genomic evolution of a non-virulent coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates Combined adjuvant effect of ginseng stem-leaf saponins and selenium on immune responses to a live bivalent vaccine of Newcastle disease virus and infectious bronchitis virus in chickens Zinc and immunity: an essential interrelation Zinc deficiency Zinc supplementation for the treatment of measles in children Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture Crossing the iron gate: why and how transferrin receptors mediate viral entry Childhood iron deficiency anemia leads to recurrent respiratory tract infections and gastroenteritis Chicken interferon type I inhibits infectious bronchitis virus replication and associated respiratory illness Prevention of experimental coronavirus colds with intranasal alpha-2b interferon Ribavirin and interferon-beta synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activation Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques Proposal for vaccination against SARS coronavirus using avian infectious bronchitis virus strain H from The Netherlands Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study Current treatment options and the role of peptides as potential therapeutic components for Middle East Respiratory Syndrome (MERS): a review Uses of intravenous gammaglobulin in immune hematologic disease Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome Strokes, thromboembolic events, and IVIg: rare incidents blemish an excellent safety record Thymosin alpha 1 and HIV-1: recent advances and future perspectives A reappraisal of thymosin alpha1 in cancer therapy Serum thymosin alpha 1 levels in normal and pathological conditions Thymosin alpha 1 antagonizes dexamethasone and CD3-induced apoptosis of CD4+ CD8+ thymocytes through the activation of cAMP and protein kinase C dependent second messenger pathways Clinical investigation of outbreak of nosocomial severe acute respiratory syndrome Anti-SARS coronavirus agents: a patent review (2008-present) Modulation of immune response in aged humans through different administration modes of thymopentin Phase variation in the modulation of the human immune response Thymopentin as adjuvant in non-responders or hyporesponders to hepatitis B vaccination The general immunopharmacology of levamisole Lymphocyte subsets in measles. Depressed helper/inducer subpopulation reversed by in vitro treatment with levamisole and ascorbic acid Systemic cyclosporine and corneal transplantation Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A Factor in virus replication and potential target for anti-viral therapy The SARS-coronavirus-host interactome: identification of cyclophilins as target for pancoronavirus inhibitors Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro Flavonoids: an overview Flavonoids from pterogyne nitens inhibit hepatitis C virus entry Inhibition of SARS-CoV 3CL protease by flavonoids Characteristics of flavonoids as potent MERS-CoV 3C-like protease inhibitors Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition Angiotensin-converting enzyme-2: a molecular and cellular perspective Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus The secret life of ACE2 as a receptor for the SARS virus Characterization of severe acute respiratory syndromeassociated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry Severe acute respiratory syndrome coronavirus entry into host cells: Opportunities for therapeutic intervention Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association Effects of chloroquine on viral infections: an old drug against today's diseases? Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Membrane-related effects underlying the biological activity of the anthraquinones emodin and barbaloin Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction Old drugs as lead compounds for a new disease?


id: cord-274231-2s7ki6g7
author: Ziebuhr, John
title: SARS – Unprecedented global response to a newly emerging disease
date: 2003-12-31
extension: .txt
mime: text/plain
words: 1215
sentence: 39
flesch: 41
cache: cache/cord-274231-2s7ki6g7.txt
txt: txt/cord-274231-2s7ki6g7.txt
summary:
  A novel coronavirus associated with severe acute respiratory syndrome The genome sequence of the SARS-associated coronavirus Lung pathology of fatal severe acute respiratory syndrome HKU/UCH SARS Study Group: Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study SARS study group: Coronavirus as a possible cause of severe acute respiratory syndrome Characterization of a novel coronavirus associated with severe acute respiratory syndrome Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection Mechanisms and enzymes involved in SARS coronavirus genome expression A 3D model of SARS-CoV 3CL proteinase and its inhibitors design by virtual screening key: cord-274231-2s7ki6g7 authors: Ziebuhr, John title: SARS – Unprecedented global response to a newly emerging disease date: 2003-12-31 journal: International Journal of Medical Microbiology DOI: 10.1078/1438-4221-00270 sha: doc_id: 274231 cord_uid: 2s7ki6g7


id: cord-256688-yy7abob9
author: Chavez, Summer
title: Coronavirus Disease (COVID-19): A primer for emergency physicians
date: 2020-03-24
extension: .txt
mime: text/plain
words: 6440
sentence: 342
flesch: 47
cache: cache/cord-256688-yy7abob9.txt
txt: txt/cord-256688-yy7abob9.txt
summary:
  COVID-19 pushing Italian ICUs toward collapse Novel Coronavirus (2019-nCoV) flowchart for healthcare professionals A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster Clinical characteristics of Coronavirus Disease 2019 in China Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected COVID-19) Interim Infection Prevention and Control Recommendations Novel Coronavirus (2019-nCoV) healthcare infection prevention and control FAQs for COVID-19 COVID-19: what is next for public health? COVID-19): evaluating and testing persons for Coronavirus Disease 2019 (COVID-19) Novel Coronavirus (2019-nCoV) evaluating and reporting PUI COVID-19) Interim Guidance for Emergency Medical Services (EMS) Systems and 911 Public Safety Answering Points (PSAPs) for COVID-19 in the United States Novel Coronavirus (2019-nCoV) infection control Surviving sepsis campaign: guidelines on the management of critically ill adults with Coronavirus Disease Infection prevention and control for coronavirus disease (COVID-19): interim guidance for acute healthcare settings Anesthesia Patient Safety Foundation Novel Coronavirus (2019-nCoV) Testing Novel Coronavirus (2019-nCoV) information for laboratories COVID-19 requests for diagnostic panels and virus COVID-19) interim guidelines for collecting, handling, and testing clinical specimens from persons under investigation (PUIs) for Coronavirus Disease 2019 (COVID-19) Detection of SARS-CoV-2 in different types of clinical specimens Correlation of chest CT and RT-PCR testing in Coronavirus Disease 2019 (COVID-19) in China: a report of 1014 cases. Up to 94% of COVID-19 cases were reported to originate from Hubei Province in December 2019; as of March 2020, the greatest number of new cases are now being reported in Italy, Spain, Germany, and the United States (U.S.) (Figs. 3 and 4)


id: cord-018078-clxzp1ph
author: Weber, Olaf
title: Coronavirus infections in veterinary medicine
date: 2005
extension: .txt
mime: text/plain
words: 4436
sentence: 226
flesch: 39
cache: cache/cord-018078-clxzp1ph.txt
txt: txt/cord-018078-clxzp1ph.txt
summary:
  As for other coronavirus infections, only a virological examination, mainly based on serological techniques, can lead to the appropriate diagnosis. key: cord-018078-clxzp1ph authors: Weber, Olaf; Schmidt, Axel title: Coronavirus infections in veterinary medicine date: 2005 journal: Coronaviruses with Special Emphasis on First Insights Concerning SARS DOI: 10.1007/3-7643-7339-3_2 sha: doc_id: 18078 cord_uid: clxzp1ph nan tion is high frequency RNA recombination [4] .


id: cord-104500-m0kfom0x
author: Kyriakopoulos, Anthony M.
title: The Potential Role of Super Spread Events in SARS-COV-2 Pandemic; a Narrative Review
date: 2020-09-21
extension: .txt
mime: text/plain
words: 6850
sentence: 247
flesch: 31
cache: cache/cord-104500-m0kfom0x.txt
txt: txt/cord-104500-m0kfom0x.txt
summary:
  Lessons from SARS epidemic taught us that the key to control is minimizing the time from the diagnosis of infection to prompt hospital isolation and diminishing the probability Table 3 : Key clinical and laboratory screening functions to appropriately forecast, prevent, and confront SARS! SARS epidemic taught us that control programs were inefficient in controlling the epidemic within a population, and failed to identify and provide a targeted infection diagnosis in groups causing potential SSEs (5, 17) .


id: cord-021152-6znmkvy9
author: Montecino-Latorre, Diego
title: Reproduction of East-African bats may guide risk mitigation for coronavirus spillover
date: 2020-02-07
extension: .txt
mime: text/plain
words: 8069
sentence: 323
flesch: 44
cache: cache/cord-021152-6znmkvy9.txt
txt: txt/cord-021152-6znmkvy9.txt
summary:
  Because CoVs are found in bat species that have adapted to be in close contact with humans, such as the straw-colored fruit bat (Eidolon helvum) and the Brazilian free-tailed bat (Tadarida brasiliensis [44, 45] ), high contact bat-human interfaces currently exist around the world. Therefore, assessment of the CoV dynamics in a broader range of bat species that show different life history traits, as well as in diverse geographic and ecological circumstances, could be extremely useful.


id: cord-294468-0v4grqa7
author: Kasilingam, Dharun
date: 2020-08-04
extension: .txt
mime: text/plain
words: 7493
sentence: 353
flesch: 48
cache: cache/cord-294468-0v4grqa7.txt
txt: txt/cord-294468-0v4grqa7.txt
title:
  Exploring the Growth of COVID‐19 Cases using Exponential Modelling Across 42 Countries and Predicting Signs of Early Containment using Machine Learning

summary:
  Data associated with the variables were collected from different official sources for a total of 42 counties with respect to COVID-19 infections as on 26 th March 2020. In line with the objectives of the study, classifiers were built based on a set of independent variables to predict if a country that has COVID-19 infections showed early signs of infection containment as a reflection of policy implementations and behaviour changes.


id: cord-294696-pm6pfeeb
author: Kunz, Y.
date: 2020-10-13
extension: .txt
mime: text/plain
words: 3243
sentence: 206
flesch: 36
cache: cache/cord-294696-pm6pfeeb.txt
txt: txt/cord-294696-pm6pfeeb.txt
title:
  Was sollte ein Urologe zu SARS-Cov-2 wissen? Risikoanalyse für urologische Operationen und Handlungsempfehlungen im klinischen Alltag

summary:
  Dieser Rauch besteht zu 95 % aus Wasser und 5 % aus Zellmaterial in der Größe von 0,007 -0,31 μm. In der Früherkennung einer drohenden Niereninsuffizienz kommt deshalb einer Urinanalyse eine wichtige Rolle zu


id: cord-286958-e1ey31eo
author: Patel, Urvish
date: 2020-08-15
extension: .txt
mime: text/plain
words: 5040
sentence: 206
flesch: 45
cache: cache/cord-286958-e1ey31eo.txt
txt: txt/cord-286958-e1ey31eo.txt
title:
  Early epidemiological indicators, outcomes, and interventions of COVID-19 pandemic: A systematic review

summary:
  All studies that compared outcomes of interest in COVID-19 patients were included. Few studies [18, 91] , have reported abnormal liver function in COVID-19 patients, and we found 20% of patients had elevated ALT and AST.


id: cord-028618-kn87q7nb
author: Flinders, Matthew
title: Democracy and the Politics of Coronavirus: Trust, Blame and Understanding
date: 2020-06-23
extension: .txt
mime: text/plain
words: 7322
sentence: 188
flesch: 38
cache: cache/cord-028618-kn87q7nb.txt
txt: txt/cord-028618-kn87q7nb.txt
summary:
  But what is also interesting about this seam of scholarship on pandemic crisis management is the manner in which it is infused with discourses not only of political blame and counter-blame, but also with discussions of self-blame, notions of shame and an awareness of the cultural apportionment of blame to specific countries or communities that is generally not discussed within the fields of public administration, executive studies or mainstream public policy (see, e.g. Abeysinghe and White, 2011; Nerlich and Koteyko, 2012) . The first section focusses on public trust in politics before the pandemic emerged and how the outbreak appears to have affected public attitudes.


id: cord-031840-k9l91unc
author: Lu, Li
title: Forum: COVID-19 Dispatches
date: 2020-09-11
extension: .txt
mime: text/plain
words: 15690
sentence: 603
flesch: 50
cache: cache/cord-031840-k9l91unc.txt
txt: txt/cord-031840-k9l91unc.txt
summary:
  Viruses are viruses are viruses. With the similar control of cases less than 20,000, Japan and South Korea remain at the heart of this imagined safe zone in company with China even though the reality has seen even fewer confirmed cases in other parts of Asia as well as the recent resurgence of virus spreading in all these three countries.


id: cord-272902-kdkyzfjv
author: Naghibzadeh, Mahmoud
date: 2020-05-21
extension: .txt
mime: text/plain
words: 5415
sentence: 243
flesch: 55
cache: cache/cord-272902-kdkyzfjv.txt
txt: txt/cord-272902-kdkyzfjv.txt
title:
  Developing an ultra-efficient microsatellite discoverer to find structural differences between SARS-CoV-1 and Covid-19

summary:
  Kmer-SSR is a package which detects simple sequence repeats of all sizes. For example, when a microsatellite with core subsequence TCG with 20 times repetition is reported, geneticists can easily interpret that for example, there is a microsatellite with core sequence CGT which is repeated 19 (or 20) times, and there is no need to highly increase the number of reported microsatellites.


id: cord-283215-dgysimh5
author: Al-Jabir, Ahmed
date: 2020-05-12
extension: .txt
mime: text/plain
words: 9062
sentence: 408
flesch: 40
cache: cache/cord-283215-dgysimh5.txt
txt: txt/cord-283215-dgysimh5.txt
title:
  Impact of the coronavirus (COVID-19) pandemic on surgical practice - Part 2 (surgical prioritisation)

summary:
  An anaesthetic guideline for COVID-19 positive patients is required. For more at risk patients (such as the elderly or immunosuppressed) with a low tumour burden, a reduced dose (≥85% of the standard dose) is recommended.


id: cord-300817-cxc00k0d
author: Saha, Jay
date: 2020-07-15
extension: .txt
mime: text/plain
words: 3254
sentence: 88
flesch: 37
cache: cache/cord-300817-cxc00k0d.txt
txt: txt/cord-300817-cxc00k0d.txt
title:
  Indoor air pollution (IAP) and pre-existing morbidities among under-5 children in India: are risk factors of coronavirus disease (COVID-19)?()

summary:
  So, compared to the other previous studies in India, this type of study is yet not done, considering this huge research gap and novelty, this study also aims to find out the risk factors associated with the Coronavirus disease (COVID-19) among under-five children using pre-existing morbidity conditions and indoor air pollution environmental factors which are solid biomass cooking fuel and indoor smoking cigarettes and also with current case fatality ratio (CFR) and recovery rate (RR) of the COVID-19 disease in the high focusing states and union territories of India which are in a risk zone. key: cord-300817-cxc00k0d authors: Saha, Jay; Chouhan, Pradip title: Indoor air pollution (IAP) and pre-existing morbidities among under-5 children in India: are risk factors of coronavirus disease (COVID-19)?


id: cord-305266-fuaq4ujb
author: Gong, Yue
title: Early Research on COVID-19: A Bibliometric Analysis
date: 2020-08-05
extension: .txt
mime: text/plain
words: 2134
sentence: 47
flesch: 16
cache: cache/cord-305266-fuaq4ujb.txt
txt: txt/cord-305266-fuaq4ujb.txt
summary:
  Chin Research advances of novel coronavirus disease (COVID-19) Current status of research on coronavirus Cross-species transmission of the newly identified coronavirus 2019-nCoV Bioinformatics analysis of the 2019 novel coronavirus genome Analysis of myocardial injury in patients with COVID-19 and association between concomitant cardiovascular diseases and severity of COVID-19 Quantifying the association between domestic travel and the exportation of novel coronavirus (2019-nCoV) cases from Wuhan, China in 2020: a correlational analysis Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges Insights into the Recent 2019 Novel Coronavirus (SARS-CoV-2) in Light of Past Human Coronavirus Outbreaks Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China Emerging novel coronavirus (2019-nCoV)-current scenario, evolutionary perspective based on genome analysis and recent developments Cross-species transmission of the newly identified coronavirus 2019-nCoV First respiratory transmitted food borne outbreak? Enteric involvement of coronaviruses: is faecal-oral transmission of SARS-CoV-2 possible? Advances on presymptomatic or asymptomatic carrier transmission of COVID-19. The Coronavirus Study Group 4 (CSG) of the International Committee on Taxonomy of Viruses designated the causative 5 virus as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the disease, 6 which subsequently spread globally, was named coronavirus disease of 2019 7 COVID-19, covering topics such as etiology, diagnosis, epidemiology, treatment, 24 prognosis, nursing, prevention and control, were available in the PubMed and China 25 national knowledge infrastructure (CNKI) databases.


id: cord-268561-vq1uhj5i
author: da Silva, Severino Jefferson Ribeiro
title: Clinical and Laboratory Diagnosis of SARS-CoV-2, the Virus Causing COVID-19
date: 2020-08-04
extension: .txt
mime: text/plain
words: 9935
sentence: 366
flesch: 36
cache: cache/cord-268561-vq1uhj5i.txt
txt: txt/cord-268561-vq1uhj5i.txt
summary:
  Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein Novel antibody epitopes dominate the antigenicity of spike glycoprotein in SARS-CoV-2 compared to SARS-CoV Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections Lack of cross-neutralization by SARS patient sera towards SARS-CoV-2 Analysis of the first cluster of cases in a family of novel coronavirus pneumonia in Gansu Province Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19) SARS-CoV-2 Seroconversion in Humans: A Detailed Protocol for a Serological Assay, Antigen Production, and Test Setup Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Test performance evaluation of SARS-CoV-2 serological assays Diagnostic performance of 7 rapid IgG/IgM antibody tests and the Euroimmun IgA/IgG ELISA in COVID-19 patients Development and Clinical Application of A Rapid IgM-IgG Combined Antibody Test for SARS-CoV-2 Infection Diagnosis Clinical Performance of Two SARS-CoV-2 Serologic Assays Serological immunochromatographic approach in diagnosis with SARS-CoV-2 infected COVID-19 patients Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease Clinical performance of different SARS-CoV-2 IgG antibody tests Evaluation of two automated and three rapid lateral flow immunoassays for the detection of anti-SARS-CoV-2 antibodies Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2 Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV Evaluation of novel antigen-based rapid detection test for the diagnosis of SARS-CoV-2 in respiratory samples Evaluation of rapid antigen test for detection of SARS-CoV-2 virus Development of a Portable, Ultra-Rapid and Ultra-Sensitive Cell-Based Biosensor for the Direct Detection of the SARS-CoV-2 S1 Microfluidic Immunoassays for Sensitive and Simultaneous Detection of IgG/IgM/Antigen of SARS-CoV-2 within 15 min 2020) In addition, several studies have been used to evaluate the clinical sensitivity of serological tests with COVID-19 patient samples collected on different days after the onset of symptoms.


id: cord-278668-v530u7h0
author: Walls, Alexandra C.
date: 2016-09-12
extension: .txt
mime: text/plain
words: 5601
sentence: 179
flesch: 38
cache: cache/cord-278668-v530u7h0.txt
txt: txt/cord-278668-v530u7h0.txt
title:
  Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy

summary:
  Because many of the observed glycosylation sites are topologically conserved among coronavirus S proteins, we suggest that the glycan footprint observed here may be representative of those of other S proteins. The lack of strict amino acid sequence conservation at the S 2 ′ cleavage site among coronavirus S proteins reflects the usage of different proteases found in distinct cellular compartments for fusion activation 15, 17 .


id: cord-279691-v5kpmk0b
author: Hagemeijer, Marne C.
title: Biogenesis and Dynamics of the Coronavirus Replicative Structures
date: 2012-11-21
extension: .txt
mime: text/plain
words: 9053
sentence: 354
flesch: 36
cache: cache/cord-279691-v5kpmk0b.txt
txt: txt/cord-279691-v5kpmk0b.txt
summary:
  [151] [152] [153] can all be applied to investigate the CoV RTCs and the membranous replicative structures at the ultrastructural level using fluorescently-tagged proteins, while EU-labeling of viral RNA in combination with correlative light-electron microscopy may provide the resolution to indisputably pinpoint the exact location of viral RNA synthesis [154] . Organelle-Like Membrane Compartmentalization of Positive-Strand RNA Virus Replication Factories Cytoplasmic Viral Replication Complexes Modification of Intracellular Membrane Structures for Virus Replication SARS-Coronavirus Replication is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum Identification of a Novel Coronavirus in Patients with Severe Acute Respiratory Syndrome A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China Bats are Natural Reservoirs of SARS-Like Coronaviruses Evolving the Largest RNA Virus Genome A Contemporary View of Coronavirus Transcription Coronaviruses use Discontinuous Extension for Synthesis of Subgenome-Length Negative Strands Sequence Motifs Involved in the Regulation of Discontinuous Coronavirus Subgenomic RNA synthesis Coronavirus Minus-Strand RNA Synthesis and Effect of Cycloheximide on Coronavirus RNA Synthesis The RNA Structures Engaged in Replication and Transcription of the A59 Strain of Mouse Hepatitis Virus The Primary Structure and Expression of the Second Open Reading Frame of the Polymerase Gene of the Coronavirus MHV-A59; a Highly Conserved Polymerase is Expressed by an Efficient Ribosomal Frameshifting Mechanism Characterization of an Efficient Coronavirus Ribosomal Frameshifting Signal: Requirement for an RNA Pseudoknot Virus-Encoded Proteinases and Proteolytic Processing in the Nidovirales Processing of Open Reading Frame 1a Replicase Proteins nsp7 to nsp10 in Murine Hepatitis Virus Strain A59 Replication Functional and Genetic Analysis of Coronavirus Replicase-Transcriptase Proteins The RNA Polymerase Activity of SARS-Coronavirus nsp12 is Primer Dependent Non-Canonical RNA-Dependent RNA Superfamily 1 Helicase has RNA and DNA Duplex-Unwinding Activities with 5'-to-3' Polarity The Severe Acute Respiratory Syndrome (SARS) Coronavirus NTPase/helicase Belongs to a Distinct Class of 5' to 3' Viral Helicases Multiple Enzymatic Activities Associated with Severe Acute Respiratory Syndrome Coronavirus Helicase Human Coronavirus 229E Nonstructural Protein 13: Characterization of Duplex-Unwinding, Nucleoside Triphosphatase, and RNA 5'-Triphosphatase Activities Functional Screen Reveals SARS Coronavirus Nonstructural Protein nsp14 as a Novel Cap N7 Methyltransferase Coronavirus Nonstructural Protein 16 is a Cap-0 Binding Enzyme Possessing (Nucleoside-2'O)-Methyltransferase Activity In Vitro Reconstitution of SARS-Coronavirus mRNA Cap Methylation Molecular Mapping of the RNA Cap 2'-O-Methyltransferase Activation Interface between Severe Acute Respiratory Syndrome Coronavirus nsp10 and nsp16 Discovery of an RNA Virus 3'→5' Exoribonuclease that is Critically Involved in Coronavirus RNA Synthesis Major Genetic Marker of Nidoviruses Encodes a Replicative Endoribonuclease RNA Recognition and Cleavage by the SARS Coronavirus Endoribonuclease Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication is Revealed by Complete Genome Sequencing An RNA Proofreading Machine Regulates Replication Fidelity and Diversity RNA 3'-End Mismatch Excision by the Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein nsp10/nsp14 Exoribonuclease Complex Identification of Severe Acute Respiratory Syndrome Coronavirus Replicase Products and Characterization of Papain-Like Protease Activity Topology and Membrane Anchoring of the Coronavirus Replication Complex:


id: cord-260225-bc1hr0fr
author: Sirpilla, Olivia
date: 2020-07-20
extension: .txt
mime: text/plain
words: 8938
sentence: 328
flesch: 32
cache: cache/cord-260225-bc1hr0fr.txt
txt: txt/cord-260225-bc1hr0fr.txt
title:
  SARS-CoV-2-Encoded Proteome and Human Genetics: From Interaction-Based to Ribosomal Biology Impact on Disease and Risk Processes

summary:
  Superfamily 1 Helicase Has RNA and DNA Duplex-Unwinding Activities with 5′-to-3′ Polarity Structure-Function Analysis of Severe Acute Respiratory Syndrome Coronavirus RNA Cap Guanine-N7-Methyltransferase Functional Screen Reveals SARS Coronavirus Nonstructural Protein Nsp14 as a Novel Cap N7 Methyltransferase Characterization of the Guanine-N7 Methyltransferase Activity of Coronavirus Nsp14 on Nucleotide GTP The Cellular RNA Helicase DDX1 Interacts with Coronavirus Nonstructural Protein 14 and Enhances Viral Replication Crystal Structure and Mechanistic Determinants of SARS Coronavirus Nonstructural Protein 15 Define an Endoribonuclease Family Crystal Structure of a Monomeric Form of Severe Acute Respiratory Syndrome Coronavirus Endonuclease Nsp15 Suggests a Role for Hexamerization as an Allosteric Switch Structural and Biochemical Characterization of Endoribonuclease Nsp15 Encoded by Middle East Respiratory Syndrome Coronavirus Binding of the Methyl Donor S-Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2′-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10 Coronavirus Nonstructural Protein 16 Is Group 2 Bat Coronaviruses A Two-Pronged Strategy to Suppress Host Protein Synthesis by SARS Coronavirus Nsp1 Protein Severe Acute Respiratory Syndrome Coronavirus Protein Nsp1 Is a Novel Eukaryotic Translation Inhibitor That Represses Multiple Steps of Translation Initiation Severe Acute Respiratory Syndrome Coronavirus Evades Antiviral Signaling: Role of Nsp1 and Rational Design of an Attenuated Strain Unique SARS-CoV Protein Nsp1: Bioinformatics, Biochemistry and Potential Effects on Virulence Coronavirus Nonstructural Protein 1: Common and Distinct Functions in the Regulation of Host and Viral Gene Expression Protein Structure and Sequence Reanalysis of 2019-NCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1


id: cord-302471-all5j2od
author: Clark, M. A.
title: Bovine coronavirus
date: 1993-12-31
extension: .txt
mime: text/plain
words: 8167
sentence: 234
flesch: 38
cache: cache/cord-302471-all5j2od.txt
txt: txt/cord-302471-all5j2od.txt
summary:
  Vaccine administration by the respiratory route has been proposed as an alternative method of stimulating active intestinal immunity without the need for primary infection of the gut, but there is still a danger that the virus is neutralized by maternal antibodies which have been absorbed systemically (Reynolds et al., 1985; Saif et al., 1986) . Activation of this enzyme causes the virus to elute from erythrocytes when the temperature is raised to 37°C (Vlasak et al., 1988a, b; Parker et al., 1990a; Vautherot et al., 1990; Schultze et al., 1991b; Storz et al., 1991) .


id: cord-256051-87alqfkd
author: Revzin, Margarita V.
date: 2020-10-01
extension: .txt
mime: text/plain
words: 8866
sentence: 300
flesch: 29
cache: cache/cord-256051-87alqfkd.txt
txt: txt/cord-256051-87alqfkd.txt
title:
  Multisystem Imaging Manifestations of COVID-19, Part 1: Viral Pathogenesis and Pulmonary and Vascular System Complications

summary:
  The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome Hypercoagulability of COVID-19 patients in intensive care unit: A report of thromboelastography findings and other parameters of hemostasis Thromboinflammation and the hypercoagulability of COVID-19 Advance in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic Indirect CT Venography at 80 kVp with Sinogram-Affirmed Iterative Reconstruction Compared to 120 kVp with Filtered Back Projection: Assessment of Image Quality and Radiation Dose Combined Direct and Indirect CT Venography (Combined CTV) in Detecting Lower Extremity Deep Vein Thrombosis Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia Incidence of venous thromboembolism in hospitalized patients with COVID-19 D-dimer is Associated with Severity of Coronavirus Disease 2019: Chest radiography is a less sensitive modality for the detection of COVID-19 lung disease when compared with that CT, with a reported baseline chest radiography sensitivity of 69% (64).


id: cord-286683-mettlmhz
author: Ortiz-Prado, Esteban
date: 2020-05-30
extension: .txt
mime: text/plain
words: 13331
sentence: 500
flesch: 37
cache: cache/cord-286683-mettlmhz.txt
txt: txt/cord-286683-mettlmhz.txt
title:
  Clinical, molecular and epidemiological characterization of the SARS-CoV2 virus and the Coronavirus disease 2019 (COVID-19), a comprehensive literature review

summary:
  medRxiv Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Temporal dynamics in viral shedding and transmissibility of COVID-19 Presumed asymptomatic carrier transmission of COVID-19 Potential presymptomatic transmission of SARS-CoV-2 Interferon-stimulated genes and their antiviral effector functions RIG-I in RNA virus recognition RNA recognition and signal transduction by RIG-I-like receptors Recognition of viral single-stranded RNA by Toll-like receptors Mechanisms of innate immune evasion in re-emerging RNA viruses Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus Infections Immunopathogenesis of coronavirus infections: implications for SARS Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology Middle East respiratory syndrome Interaction of SARS and MERS coronaviruses with the antiviral interferon response SARS and MERS: recent insights into emerging coronaviruses Dysregulation of immune response in patients with COVID-19 in Wuhan Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of the macrophage activation syndrome: Re-analysis of a prior Phase III trial A multicenter, randomized controlled trial for the efficacy and safety of tocilizumab in the treatment of new coronavirus pneumonia (COVID-19) Effects of chloroquine on viral infections: an old drug against today's diseases Chloroquine is a potent inhibitor of SARS coronavirus infection and spread In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Baricitinib as potential treatment for 2019-nCoV acute respiratory disease COVID-19: consider cytokine storm syndromes and immunosuppression. Three recent examples of these viral jumps include SARS CoV, MERS-CoV and SARS CoV-2 virus.


id: cord-258679-rlfsqgm7
author: Rha, Brian
title: Update: Severe Respiratory Illness Associated with a Novel Coronavirus — Worldwide, 2012–2013
date: 2013-03-15
extension: .txt
mime: text/plain
words: 1004
sentence: 39
flesch: 42
cache: cache/cord-258679-rlfsqgm7.txt
txt: txt/cord-258679-rlfsqgm7.txt
summary:
  Persons who develop severe acute lower respiratory illness of known etiology within 10 days after traveling from the Arabian Peninsula or neighboring countries but who do not respond to appropriate therapy may be considered for evaluation for novel coronavirus infection. In addition, persons who develop severe acute lower respiratory illness who are close contacts † of a symptomatic traveler who developed fever and acute respiratory illness within 10 days of traveling from the Arabian Peninsula or neighboring countries may be considered for evaluation for novel coronavirus infection.


id: cord-262735-xj9md751
author: Li, Lian Yong
date: 2020-05-12
extension: .txt
mime: text/plain
words: 1287
sentence: 45
flesch: 33
cache: cache/cord-262735-xj9md751.txt
txt: txt/cord-262735-xj9md751.txt
title:
  Digestive system involvement of novel coronavirus infection: Prevention and control infection from a gastroenterology perspective

summary:
  key: cord-262735-xj9md751 authors: Li, Lian Yong; Wu, Wei; Chen, Sheng; Gu, Jian Wen; Li, Xin Lou; Song, Hai Jing; Du, Feng; Wang, Gang; Zhong, Chang Qing; Wang, Xiao Ying; Chen, Yan; Shah, Rushikesh; Yang, He Ming; Cai, Qiang title: Digestive system involvement of novel coronavirus infection: Prevention and control infection from a gastroenterology perspective date: 2020-05-12 journal: J Dig Dis DOI: 10.1111/1751-2980.12862 sha: doc_id: 262735 cord_uid: xj9md751 An epidemic of an acute respiratory syndrome caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in Wuhan, China, now known as coronavirus disease 2019 (COVID‐19), beginning in December 2019, has attracted an intense amount of attention worldwide. Diagnosis and clinical management of 2019 novel coronavirus infection: an operational recommendation of Peking Union Medical College Hospital (V2.0) Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China Potent neutralization of 2019 novel coronavirus by recombinant ACE2-Ig Three cases of novel coronavirus pneumonia with viral nucleic acids still positive in stool after throat swab detection turned negative Digestive system involvement of novel coronavirus infection: Prevention and control infection from a gastroenterology perspective


id: cord-321670-f2d4bykp
author: Longardt, Ann Carolin
title: Perinatale Aspekte der SARS-CoV-2 Infektion
date: 2020-08-24
extension: .txt
mime: text/plain
words: 2938
sentence: 203
flesch: 48
cache: cache/cord-321670-f2d4bykp.txt
txt: txt/cord-321670-f2d4bykp.txt
summary:
  Da das Frühgeborene unmittelbar nach der Entbindung durch Sectio von der Mutter isoliert und nicht durch die Mutter gestillt wurde, erscheint eine postpartale Infektion nach Angaben der Autoren unwahrscheinlich und damit eine vertikale Transmission naheliegend [37] . Abgesehen davon, dass das Virus selten im Blut detektiert wurde, stellt sich auch die Frage nach der Expres sion des SARS-CoV-2-Rezeptors ACE2 im Bereich der maternofetalen Grenzfläche beziehungsweise in der Plazenta.


id: cord-298156-d0pb1kik
author: Cheval, Sorin
title: Observed and Potential Impacts of the COVID-19 Pandemic on the Environment
date: 2020-06-10
extension: .txt
mime: text/plain
words: 11035
sentence: 444
flesch: 42
cache: cache/cord-298156-d0pb1kik.txt
txt: txt/cord-298156-d0pb1kik.txt
summary:
  Supplementary Materials: The following are available online at http://www.mdpi.com/1660-4601/17/11/4140/s1, List S1: Calendar of events relevant for COVID-19 impact on environment (31 December 2019-30 April 2020), Figure S1 : The examination of the relationship between climate and Coronavirus focuses on two queries: (a) how the climate can modulate the spread and persistence of the virus, and (b) the extent of the impact of the virus on economic policies taken to offset climate impacts.


id: cord-253077-61fmul8c
author: Vabret, Nicolas
title: Immunology of COVID-19: current state of the science
date: 2020-05-06
extension: .txt
mime: text/plain
words: 20264
sentence: 601
flesch: 30
cache: cache/cord-253077-61fmul8c.txt
txt: txt/cord-253077-61fmul8c.txt
summary:
  Tan et al. proposed a prognostic model based on lymphocyte counts at two time points: patients with less than 20% lymphocytes at days 10-12 from the onset of symptoms and less than 5% at days 17-19 had the worst outcomes in this study (Tan et al., 2020a) . Antibodies binding the SARS-CoV-2 internal N protein and the external S glycoprotein are commonly detected (Amanat et al., 2020; Ju et al., 2020; .


id: cord-030934-t7akdu6x
author: Bahrami, Afsane
title: Genetic and pathogenic characterization of SARS-CoV-2: a review
date: 2020-08-26
extension: .txt
mime: text/plain
words: 6490
sentence: 235
flesch: 36
cache: cache/cord-030934-t7akdu6x.txt
txt: txt/cord-030934-t7akdu6x.txt
summary:
  SARS-CoV-2 shares 80% nucleotide identity to SARS-CoV. The S, E, M, N and ORF3a genes of SARS-CoV-2 are predicted to be 3822, 228, 669, 1260 and 828 nucleotides in length, respectively.


id: cord-292912-ufcvecwo
author: Qiu, Ruijin
date: 2020-03-08
extension: .txt
mime: text/plain
words: 1886
sentence: 88
flesch: 42
cache: cache/cord-292912-ufcvecwo.txt
txt: txt/cord-292912-ufcvecwo.txt
title:
  Outcome reporting from protocols of clinical trials of Coronavirus Disease 2019 (COVID-19): a review

summary:
  key: cord-292912-ufcvecwo authors: Qiu, Ruijin; Wei, Xuxu; Zhao, Mengzhu; Zhong, Changming; Zhao, Chen; Hu, Jiayuan; Li, Min; Huang, Ya; Han, Songjie; He, Tianmai; Chen, Jing; Shang, Hongcai title: Outcome reporting from protocols of clinical trials of Coronavirus Disease 2019 (COVID-19): a review date: 2020-03-08 journal: nan DOI: 10.1101/2020.03.04.20031401 sha: doc_id: 292912 cord_uid: ufcvecwo Objectives: To examine heterogeneity of outcomes in protocols of clinical trials of Coronavirus Disease 2019 (COVID-19) and to identify outcomes for prioritization in developing a core outcome set (COS) in this field. Conclusion: Outcome reporting in protocols of clinical trials of COVID-19 is inconsistent.


id: cord-319983-e4f2sfl4
author: Tripathi, Shweta
title: The COVID-19: Current understanding
date: 2020-09-26
extension: .txt
mime: text/plain
words: 4301
sentence: 208
flesch: 48
cache: cache/cord-319983-e4f2sfl4.txt
txt: txt/cord-319983-e4f2sfl4.txt
summary:
  Recent studies from China and France observed that the administration of this drug in COVID-19 patients produced significant results in both clinical outcomes as well as in viral clearance Recently a medical practitioner from Shanghai used plasma therapy to treat COVID-19 patients and yielded positive results with rapid recovery, suggesting it could be a potential treatment for COVID-19 patients.


id: cord-312178-tojgojjf
author: Segars, James
title: Prior and Novel Coronaviruses, COVID-19, and Human Reproduction: What Is Known?
date: 2020-04-16
extension: .txt
mime: text/plain
words: 5366
sentence: 221
flesch: 41
cache: cache/cord-312178-tojgojjf.txt
txt: txt/cord-312178-tojgojjf.txt
summary:
  An in silico analysis Structure, Function, and Evolution of Coronavirus Spike Proteins Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptorbinding site in spike protein domain A Structural insights into coronavirus entry Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains Ezrin interacts with the SARS coronavirus Spike protein and restrains infection at the entry stage Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2 Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways In a 2005 study of eight postmortem SARS-CoV patients, testicular tissue contained focal atrophy despite lacking identifiable SARS viral RNA (24) .


id: cord-287221-oh7lnxwt
author: Kock, Florian
title: Understanding the COVID-19 tourist psyche: The Evolutionary Tourism Paradigm
date: 2020-09-09
extension: .txt
mime: text/plain
words: 8389
sentence: 321
flesch: 35
cache: cache/cord-287221-oh7lnxwt.txt
txt: txt/cord-287221-oh7lnxwt.txt
summary:
  Yet, despite its potential, the application of evolutionary psychology in tourism research is scant. We postulate that the investigation of tourists' COVID-19 psyche and the paradigm shift in tourists' behavior demands new theory-based mindsets to be leveraged in tourism research.


id: cord-329454-69z28yli
author: Humar, Atul
title: Severe acute respiratory syndrome and the liver
date: 2004-01-30
extension: .txt
mime: text/plain
words: 1890
sentence: 76
flesch: 36
cache: cache/cord-329454-69z28yli.txt
txt: txt/cord-329454-69z28yli.txt
summary:
  Reverse transcriptase polymerase chain reaction (RT-PCR) was positive for SARS coronavirus in liver tissue from all three patients, although virions could not be detected either by plaque assay on Vero cells or by electron microscopy. Defining the basis for susceptibility to severe inflammatory outcomes after coronavirus infection has obvious implications for the study and treatment of clinical SARS.


id: cord-331822-rsnzyheu
author: Hu, Yuli
title: Prevention of fogging of protective eyewear for medical staff during the COVID-19 pandemic
date: 2020-05-08
extension: .txt
mime: text/plain
words: 376
sentence: 11
flesch: 34
cache: cache/cord-331822-rsnzyheu.txt
txt: txt/cord-331822-rsnzyheu.txt
summary:
  The Anti-fogging treatments 118 of medical goggles during the Covid-19 The experience of using goggles The observation of the application and effect 125 of using different anti-fogging methods in the intensive care isolation 126 units during Covid-19 The anti-fogging application of the 129 antibacterial hand gel to the reuse goggles during the protection 130 against Covid-19 Not applicable. 97 Interim guidance The epidemics of myopia Aetiology and prevention Lack of Middle East respiratory syndrome coronavirus infection in Thailand Application effect of 106 several anti-fogging methods on medical Anti-fog skills for medical goggles during the 110 period of prevention and control of Coronavirus disease 2019 Two simple methods dealing with the 114 problem of fogged goggles during the protection against Coronavirus 115 disease 2019 Ling Lie etal.


id: cord-306465-7kevsl1z
author: Agarwal, Krishna Mohan
title: Study and Overview of the Novel Corona Virus Disease (COVID-19)
date: 2020-09-06
extension: .txt
mime: text/plain
words: 2649
sentence: 83
flesch: 43
cache: cache/cord-306465-7kevsl1z.txt
txt: txt/cord-306465-7kevsl1z.txt
summary:
  key: cord-306465-7kevsl1z authors: Agarwal, Krishna Mohan; Mohapatra, Swati; Sharma, Prairit; Sharma, Shreya; Bhatia, Dinesh; Mishra, Animesh title: Study and Overview of the Novel Corona Virus Disease (COVID-19) date: 2020-09-06 journal: nan DOI: 10.1016/j.sintl.2020.100037 sha: doc_id: 306465 cord_uid: 7kevsl1z In December 2019, a new disease with pneumonia-like symptoms was spreading throughout Wuhan in China which was entitled as novel coronavirus disease or COVID -19 caused by the virus SARS CoV-2. India coronavirus numbers explained: Cases in four states growing faster than the national average Nearly 7 Lakh Coronavirus Cases In India Recent Advancements in the Diagnosis, Prevention, and Prospective Drug Therapy of COVID-19.


id: cord-303517-8971aq02
author: Cajamarca-Baron, Jairo
title: SARS-CoV-2 (COVID-19) in Patients with some Degree of Immunosuppression
date: 2020-10-16
extension: .txt
mime: text/plain
words: 9107
sentence: 288
flesch: 33
cache: cache/cord-303517-8971aq02.txt
txt: txt/cord-303517-8971aq02.txt
summary:
  In this review, we will focus on describing the literature on SARS-COV-2 infection in patients with some degree of immunosuppression, other than rheumatological diseases, among these, cancer patients, transplant recipients, primary immunodeficiency, and HIV patients. Therefore, special recommendations should be considered for these patients, such as postponing adjuvant chemotherapy or elective surgery in people with stable cancer, especially in endemic areas, adopting stricter personal protection measures for cancer patients or cancer survivors, and considering stricter surveillance or treatment when cancer patients are infected with SARS-CoV-2.


id: cord-262119-s6hc7fxs
author: Ostaszewski, Marek
date: 2020-10-27
extension: .txt
mime: text/plain
words: 12366
sentence: 519
flesch: 31
cache: cache/cord-262119-s6hc7fxs.txt
txt: txt/cord-262119-s6hc7fxs.txt
title:
  COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms

summary:
  COVID-19 pathways featured in the previous section cover mechanisms reported so far. By aligning our efforts, we strive to provide COVID-19 specific pathway models, synchronize content with similar resources and encourage discussion and feedback at every stage of the curation process.


id: cord-345503-52kq2u8a
author: Keyhan, Seied Omid
date: 2020-03-30
extension: .txt
mime: text/plain
words: 960
sentence: 32
flesch: 35
cache: cache/cord-345503-52kq2u8a.txt
txt: txt/cord-345503-52kq2u8a.txt
title:
  Dysosmia and dysgeusia due to the 2019 Novel Coronavirus; a hypothesis that needs further investigation

summary:
  Routes intended for central nervous system infection with coronaviruses are peripheral trigeminal or olfactory nerves following intranasal inoculation [6, 7] . These studies suggest that the human central nervous system (CNS) may be susceptible to coronavirus infection


id: cord-287758-da11ypiy
author: Mônica Vitalino de Almeida, Sinara
title: COVID-19 therapy: what weapons do we bring into battle?
date: 2020-09-10
extension: .txt
mime: text/plain
words: 17493
sentence: 650
flesch: 35
cache: cache/cord-287758-da11ypiy.txt
txt: txt/cord-287758-da11ypiy.txt
summary:
  More preclinical and clinical studies are required to prove whether dasatinib is really promising for COVID-19 patient treatment. SBV is also combined with other antiviral drugs, such as ledipasvir, velpatasvir and voxilaprevir.


id: cord-311847-2czqs84q
author: Pennisi, Manuela
title: SARS-CoV-2 and the Nervous System: From Clinical Features to Molecular Mechanisms
date: 2020-07-31
extension: .txt
mime: text/plain
words: 9018
sentence: 356
flesch: 36
cache: cache/cord-311847-2czqs84q.txt
txt: txt/cord-311847-2czqs84q.txt
summary:
  The differences in the sequence of spike proteins between SARS-CoV and SARS-CoV-2 will enable scientists to identify epitopes in COVID-19 patients for the development of monoclonal antibodies against this virus. COVID-19: Consider cytokine storm syndromes and immunosuppression Analysis of clinical characteristics and laboratory findings of 95 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A retrospective analysis The interface between stroke and infectious disease: Infectious diseases leading to stroke and infections complicating stroke The clinical pathology of severe acute respiratory syndrome (SARS): A report from Progression in migraine: Role of mast cells and pro-inflammatory and anti-inflammatory cytokines The pathogenesis and treatment of the 'Cytokine Storm' in COVID-19 Analysis of the clinical effect of olfactory training on olfactory dysfunction after upper respiratory tract infection Anosmia in COVID-19: A Bumpy Road to Establishing a Cellular Mechanism Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters Olfactory transmucosal SARS-CoV-2 invasion as port of Central Nervous System entry in COVID-19 patients A Mouse Model of SARS-CoV-2 Infection and Pathogenesis Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences Smell and taste dysfunction in patients with SARS-CoV-2 infection: A review of epidemiology, pathogenesis, prognosis, and treatment options.


id: cord-323618-d09b65gd
author: Vabret, A.
title: Coronavirus humains (HCoV)
date: 2008-05-05
extension: .txt
mime: text/plain
words: 6306
sentence: 281
flesch: 52
cache: cache/cord-323618-d09b65gd.txt
txt: txt/cord-323618-d09b65gd.txt
summary:
  développées à partir des souches circulant en 2003, elles devront être réévaluées en cas de résurgence de ce virus. L'apparente plasticité de la protéine S et du RBD permettrait aux coronavirus de s'adapter à différents récepteurs protéiques ou à des récepteurs hétérologues dans différentes espèces et serait un atout pour émerger chez de nouveaux hôtes.


id: cord-259229-e8m8m4ut
author: Samidurai, Arun
title: Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic Strategies
date: 2020-09-16
extension: .txt
mime: text/plain
words: 10793
sentence: 383
flesch: 30
cache: cache/cord-259229-e8m8m4ut.txt
txt: txt/cord-259229-e8m8m4ut.txt
summary:
  While the ACE2 gene is located on the X-chromosome, gender has an impact among COVID-19 patients, where men are at increased risk of susceptibility to COVID-19 infection and CVD complications due to their hemizygous allele for ACE2 compared to heterozygous allele in female [28] . Several promising therapeutics are under investigation to the overall prognosis of COVID-19 patients with high risk of cardiovascular impairment, nevertheless to date, none have shown proven clinical efficacy.


id: cord-328644-odtue60a
author: Comandatore, Francesco
title: Insurgence and worldwide diffusion of genomic variants in SARS-CoV-2 genomes
date: 2020-05-28
extension: .txt
mime: text/plain
words: 6537
sentence: 187
flesch: 37
cache: cache/cord-328644-odtue60a.txt
txt: txt/cord-328644-odtue60a.txt
summary:
  If a functional role for this mutation will be demonstrated, this pattern seems to indicate that different variants might have different fitness when interacting with different host's haplotypes, i.e. in case Asian and European have different haplotypes concerning some of the proteins interacting with the Spike, like for instance Furin. When focusing on single Clades across all macro-regions previously defined, we find a heterogeneous situation with different variants increasing in time in different countries.


id: cord-327454-o1mrpgvj
author: Hemmati-Dinarvand, Farshad
title: Mysterious Virus: A Review on Behavior and Treatment Approaches of the Novel Coronavirus, 2019-nCoV
date: 2020-05-06
extension: .txt
mime: text/plain
words: 3231
sentence: 103
flesch: 36
cache: cache/cord-327454-o1mrpgvj.txt
txt: txt/cord-327454-o1mrpgvj.txt
summary:
  respiratory syndrome coronavirus TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV Emergence of novel coronavirus 2019-nCoV: need for rapid vaccine and biologics development Recent apprise on coronavirus and its terrible insinuations Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study A familial cluster of infection associated with the 2019 novel coronavirus indicating possible person-to-person transmission during the incubation period Initial public health response and interim clinical guidance for the 2019 novel coronavirus outbreak-United States Persons evaluated for 2019 novel coronavirus-United States Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records Pathological findings of COVID-19 associated with acute respiratory distress syndrome Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster A new coronavirus associated with human respiratory disease in China Importation and human-to-human transmission of a novel coronavirus in Vietnam A locally transmitted case of SARS-CoV-2 infection in Taiwan National Recommendations for Diagnosis and Treatment of pneumonia caused by 2019-nCoV (the 4th edition). It is worth noting that J. x-x Running title: 2019-nCoV; Behavior and Treatment Approaches Outbreak of Pneumonia of Unknown Etiology in Wuhan China: the Mystery and the Miracle Emerging coronaviruses: genome structure, replication, and pathogenesis Recent insights into 2019-nCoV: a brief but comprehensive review Origin and evolution of pathogenic coronaviruses Coronavirus infections and immune responses A novel coronavirus from patients with pneumonia in China Severe acute respiratory syndrome-related coronavirus-The species and its viruses, a statement of the Coronavirus Study Group 50 years of the International Committee on Taxonomy of Viruses: progress and prospects A new emerging zoonotic virus of concern: the 2019 novel Coronavirus (COVID-19) Family coronaviridae A47 Origin and possible genetic recombination of the middle east respiratory syndrome coronavirus from the first imported case in china: phylogenetics and coalescence analysis Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding A pneumonia outbreak associated with a new coronavirus of probable bat origin The molecular biology of coronaviruses Emerging novel coronavirus (2019-nCoV)-current scenario, evolutionary perspective based on genome analysis and recent developments Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Structure of SARS coronavirus spike receptor-binding domain complexed with receptor Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin Immunohistochemical, in situ hybridization, and ultrastructural localization of SARS-associated coronavirus in lung of a fatal case of severe acute respiratory syndrome in Taiwan Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus.


id: cord-320955-xhp96abg
author: Allam, Zaheer
date: 2020-07-24
extension: .txt
mime: text/plain
words: 4759
sentence: 165
flesch: 51
cache: cache/cord-320955-xhp96abg.txt
txt: txt/cord-320955-xhp96abg.txt
title:
  The First 50 days of COVID-19: A Detailed Chronological Timeline and Extensive Review of Literature Documenting the Pandemic

summary:
  Researchers Develop First Diagnostic Test for Novel Coronavirus in China Cluster of Pneumonia Cases Caused by a Novel Coronavirus Event Background COVID-19 Update: Cluster of Pneumonia Cases Associated With Novel Coronavirus e Wuhan, China -2019 China's New SARS-like Virus Has Spread to Japan, But we Still Know Very Little About it Clinical Features of Patients Infected With 2019 Novel Coronavirus in Wuhan Report 1: Estimating the Potential Total Number of Novel Coronavirus Cases in Wuhan City Wuhan Wet Market WeChat Saw Spikes in the Terms 'SARS,' 'Coronavirus,' and 'Shortness of Breath Japan Confirms First Case of Infection From Wuhan Coronavirus;


id: cord-349923-cja8i0hw
author: Habibzadeh, Parham
title: The Novel Coronavirus: A Bird's Eye View
date: 2020-02-05
extension: .txt
mime: text/plain
words: 2467
sentence: 82
flesch: 38
cache: cache/cord-349923-cja8i0hw.txt
txt: txt/cord-349923-cja8i0hw.txt
summary:
  The coronavirus has infected more than 870 people Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia Dynamically modeling SARS and other newly emerging respiratory illnesses: past, present, and future Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical features of patients infected with 2019 novel coronavirus in Wuhan Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome Functions and regulation of T cell-derived interleukin-10 Transmission of 2019-nCoV infection from an asymptomatic contact in Germany Sexual dimorphism in innate immunity The X chromosome in immune functions: when a chromosome makes the difference Chinese researchers reveal draft genome of virus implicated in Wuhan pneumonia outbreak Available from www.who.int/publications-detail/laboratorytesting-for-2019-novel-coronavirus-in-suspectedhuman-cases-20200117 Available from www.niaid.nih.gov/diseases-conditions/mers-sars-therapeutics-vaccines First case of 2019 novel coronavirus in the United States A randomized, open-label, blank-controlled trial for the efficacy and safety of lopinavir-ritonavir and interferon-alpha 2b in hospitalization patients with novel coronavirus infection. In contrast to re v i e w patients with typical human coronavirus infections, few of those affected with the novel coronavirus had upper respiratory tract signs and symptoms (eg, sore throat, rhinorrhea).


id: cord-349417-vn7q8wc4
author: Ziebuhr, John
title: The Coronavirus Replicase: Insights into a Sophisticated Enzyme Machinery
date: 2006
extension: .txt
mime: text/plain
words: 3389
sentence: 107
flesch: 33
cache: cache/cord-349417-vn7q8wc4.txt
txt: txt/cord-349417-vn7q8wc4.txt
summary:
  A detailed sequence analysis by Gorbalenya, Snijder and colleagues of the SARS-CoV genome revealed that the enzymology of coronavirus RNA synthesis may be significantly more complex than previously thought. It will be of particular interest to identify those proteins that are involved in the specific mechanisms of coronavirus RNA synthesis, such as the production of a nested set of subgenome-length RNAs and the replication of RNA genomes of unprecedented size.


id: cord-344646-wvx6q999
title: Note from the editors: novel coronavirus (2019-nCoV)
date: 2020-01-23
extension: .txt
mime: text/plain
words: 568
sentence: 22
flesch: 43
cache: cache/cord-344646-wvx6q999.txt
txt: txt/cord-344646-wvx6q999.txt
summary:
  Interim guidance Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 In order to support public health action, viral genome sequences were released by Chinese researchers on 10 January [4] and 2 days later, four further sequences were also made available on the Global Initiative on Sharing All Influenza Data (GISAID) (https://www.gisaid.org/).


id: cord-308857-otsrexqu
author: Goel, Saurav
date: 2020-05-28
extension: .txt
mime: text/plain
words: 10617
sentence: 435
flesch: 43
cache: cache/cord-308857-otsrexqu.txt
txt: txt/cord-308857-otsrexqu.txt
title:
  Resilient and Agile Engineering Solutions to Address Societal Challenges such as Coronavirus Pandemic

summary:
  Antibodies help prevent future infections by detecting the virus and binding to their surfaces signalling the body's immune system to destroy such viruses or virus-infected cells. PSS organic electrochemical transistors for chemical and biological sensors: a mini review COVID-19: A Risk Assessment Perspective Phylogenetic network analysis of SARS-CoV-2 genomes Anti-HIV drug repurposing against SARS-CoV-2 Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Fast Identification of Possible Drug Treatment of Coronavirus Disease-19 (COVID-19) through Computational Drug Repurposing Study Structure of Mpro from COVID-19 virus and discovery of its inhibitors Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals COVID-19:


id: cord-312434-yx24golq
author: Deng, Ziqin
date: 2020-09-23
extension: .txt
mime: text/plain
words: 6227
sentence: 204
flesch: 40
cache: cache/cord-312434-yx24golq.txt
txt: txt/cord-312434-yx24golq.txt
title:
  Bibliometric and Visualization Analysis of Human Coronaviruses: Prospects and Implications for COVID-19 Research

summary:
  Leading researchers from various fields of human coronavirus research are listed to facilitate collaboration and promote effective disease prevention and control. This is partially due to the unclear knowledge map of human coronavirus research and an inadequate understanding of the present research status, hotspots and development trends.


id: cord-291916-5yqc3zcx
author: Hozhabri, Hossein
date: 2020-08-05
extension: .txt
mime: text/plain
words: 16799
sentence: 651
flesch: 39
cache: cache/cord-291916-5yqc3zcx.txt
txt: txt/cord-291916-5yqc3zcx.txt
title:
  The Global Emergency of Novel Coronavirus (SARS-CoV-2): An Update of the Current Status and Forecasting

summary:
  This form of adaptation required a series of amino acid changes in the RBD within the S protein of SARS viruses that circulated in bats [56, 68] . Strategies for controlling emerging coronaviruses A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice Cross-species transmission of the newly identified coronavirus 2019-nCoV Towards a solution to MERS:


id: cord-351707-u8t7h6ri
author: Dammeyer, Jesper
date: 2020-12-01
extension: .txt
mime: text/plain
words: 3700
sentence: 164
flesch: 51
cache: cache/cord-351707-u8t7h6ri.txt
txt: txt/cord-351707-u8t7h6ri.txt
title:
  An explorative study of the individual differences associated with consumer stockpiling during the early stages of the 2020 Coronavirus outbreak in Europe

summary:
  Significant associations were found, with high scores on SDO-E and high total SDO scores associated with Action reasons for extra shopping. High scores on Conscientiousness were also associated with a lower tendency to engage in extra shopping.


id: cord-319578-n1ee1688
author: Kakhki, Reza Kamali
title: COVID-19 target: A specific target for novel coronavirus detection
date: 2020-05-30
extension: .txt
mime: text/plain
words: 762
sentence: 24
flesch: 32
cache: cache/cord-319578-n1ee1688.txt
txt: txt/cord-319578-n1ee1688.txt
summary:
  The modified comparative genomics approach helps us to find novel specific targets by comparing two or more sequences on the nucleotide collection database. Although molecular methods such as RT-PCR and real-time PCR are among the most common procedures in detecting coronavirus, the use of specific targets still is the first critical step in the accurate diagnosis of the agent.


id: cord-279488-oc0edgd2
author: Nguyen, Trieu
date: 2020-03-14
extension: .txt
mime: text/plain
words: 3243
sentence: 157
flesch: 52
cache: cache/cord-279488-oc0edgd2.txt
txt: txt/cord-279488-oc0edgd2.txt
title:
  2019 Novel Coronavirus Disease (COVID-19): Paving the Road for Rapid Detection and Point-of-Care Diagnostics

summary:
  For virus detection, for example, influenza [40] or human norovirus, LAMP assay offers one-step detection [38] (Veterinary, Portable, Onsite Detection), in the VIVALDI project, detection time can be less than 1 h.


id: cord-321259-wio2b49i
author: Carmona-Gutierrez, Didac
title: Digesting the crisis: autophagy and coronaviruses
date: 2020-05-04
extension: .txt
mime: text/plain
words: 4365
sentence: 165
flesch: 26
cache: cache/cord-321259-wio2b49i.txt
txt: txt/cord-321259-wio2b49i.txt
summary:
  lifespan extension by the natural polyamine spermidine Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes Polyamines and Their Role in Virus Infection Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses The Interplay Between Pattern Recognition Receptors and Autophagy in Inflammation Pathogen recognition and innate immunity Autophagy Promotes MHC Class II Presentation of Peptides from Intracellular Source Proteins Autophagy Beyond Intracellular MHC Class II Antigen Presentation Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection The relationship between autophagy and the immune system and its applications for tumor immunotherapy Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance Autophagy is a critical regulator of memory CD8+ T cell formation Polyamines Control eIF5A Autophagy and inflammasomes Secretory autophagy Human placental trophoblasts confer viral resistance to recipient cells Human TANK-binding kinase 1 is required for early autophagy induction upon herpes simplex virus 1 infection A discovery platform for the identification of caloric restriction mimetics with broad health-improving effects Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential Given the devastating consequences of the current COVID-19 pandemic, the question arises whether manipulating autophagy might be an expedient approach to fight the novel coronavirus SARS-CoV-2.


id: cord-318392-r9bbomvk
author: Woo, Patrick CY
date: 2017-06-21
extension: .txt
mime: text/plain
words: 3781
sentence: 130
flesch: 45
cache: cache/cord-318392-r9bbomvk.txt
txt: txt/cord-318392-r9bbomvk.txt
title:
  Coronavirus HKU15 in respiratory tract of pigs and first discovery of coronavirus quasispecies in 5′-untranslated region

summary:
  The presence of the virus in respiratory samples provides an alternative clinical sample to confirm the diagnosis of Coronavirus HKU15 infection. Third, the presence of the virus in respiratory samples provides an alternative clinical sample to confirm the diagnosis of Coronavirus HKU15 infection.


id: cord-340357-gyvvcnuf
author: Fallahi, Hamid Reza
title: Being a front-line dentist during the Covid-19 pandemic: a literature review
date: 2020-04-24
extension: .txt
mime: text/plain
words: 3825
sentence: 163
flesch: 42
cache: cache/cord-340357-gyvvcnuf.txt
txt: txt/cord-340357-gyvvcnuf.txt
summary:
  In: Roles of Host Gene and Non-coding RNA Expression in Virus Infection Understanding of COVID-19 based on current evidence Transmission of 2019-nCoV infection from an asymptomatic contact in Germany A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats Risk of hepatitis B virus transmission via dental handpieces and evaluation of an antisuction device for prevention of transmission The severe acute respiratory syndrome Chinese researchers reveal draft genome of virus implicated in Wuhan pneumonia outbreak Laboratory testing of 2019 novel coronavirus ( 2019-nCoV) in suspected human cases: interim guidance ADA releases coronavirus handout for dentists based on CDC guidelines: American Dental Association CDC reminds clinicians to use standard precautions, recommends isolating patients with coronavirus symptoms: American Dental Association Maxillofacial Plastic and Reconstructive Surgery Novel Coronavirus: American Dental Association 2019-nCoV transmission through the ocular surface must not be ignored Consistent detection of 2019 novel coronavirus in saliva Ocular tropism of respiratory viruses First case of 2019 novel coronavirus in the United States Transmission routes of 2019-nCoV and controls in dental practice Going global-Travel and the 2019 novel coronavirus Functional assessment of cell entry and receptor usage for lineage B Î²-coronaviruses A pneumonia outbreak associated with a new coronavirus of probable bat origin Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques Persistence of coronaviruses on inanimate surfaces and its inactivation with biocidal agents Pathogenicity and Transmissibility of 2019-nCoV-A Quick Overview and Comparison with Other Emerging Viruses Transmission of blood-borne pathogens in US dental health care settings: 2016 update Aerosols and splatter in dentistry: a brief review of the literature and infection control implications Transmission routes of 2019-nCoV and controls in dental practice Transmission of SARS and MERS coronaviruses and influenza virus in healthcare settings: the possible role of dry surface contamination Transmission routes of 2019-nCoV and controls in dental practice Office of State Administration of Traditional Chinese Medicine. ACE2+ epithelial cells present in the salivary glands were considered one of the main targets of SARS coronavirus infection.


id: cord-308537-i6um5iu2
author: Hoskins, Johnny D.
title: Coronavirus Infection in Cats
date: 1993-01-31
extension: .txt
mime: text/plain
words: 5270
sentence: 241
flesch: 35
cache: cache/cord-308537-i6um5iu2.txt
txt: txt/cord-308537-i6um5iu2.txt
summary:
  28 Most cats subsequently do not show clinical evidence of FIP coronavirus infection. Removal of healthy coronavirus antibodypositive cats from catteries or multicat household is justified only if strong evidence that the cat is a source of FIP coronavirus infection for other cats exists.


id: cord-344486-iu5flbcl
author: Chiotos, Kathleen
title: Multicenter interim guidance on use of antivirals for children with COVID-19/SARS-CoV-2
date: 2020-09-12
extension: .txt
mime: text/plain
words: 8619
sentence: 254
flesch: 24
cache: cache/cord-344486-iu5flbcl.txt
txt: txt/cord-344486-iu5flbcl.txt
summary:
  Antiviral Activity and Safety of Darunavir/Cobicistat for the Treatment of COVID-19 Comparison of hydroxychloroquine, lopinavir/ritonavir, and standard of care in critically ill patients with SARS-CoV-2 pneumonia: an opportunistic retrospective analysis Stopping lopinavir/ritonavir in COVID-19 patients: duration of the drug interacting effect Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study Guidance statement: Remdesivir is suggested for children with severe COVID-19.


id: cord-322456-5at1euqm
author: Rokohl, Alexander C.
title: Die Rolle der Augenheilkunde in der COVID-19-Pandemie
date: 2020-06-09
extension: .txt
mime: text/plain
words: 1849
sentence: 119
flesch: 40
cache: cache/cord-322456-5at1euqm.txt
txt: txt/cord-322456-5at1euqm.txt
summary:
  Zudem soll die Rolle der Ophthalmologie bei der Therapie von COVID-19 erörtert werden. key: cord-322456-5at1euqm authors: Rokohl, Alexander C.; Loreck, Niklas; Wawer Matos, Philomena A.; Mor, Joel M.; Zwingelberg, Sarah; Grajewski, Rafael S.; Cursiefen, Claus; Heindl, Ludwig M. title: Die Rolle der Augenheilkunde in der COVID-19-Pandemie date: 2020-06-09 journal: Ophthalmologe DOI: 10.1007/s00347-020-01148-9 sha: doc_id:


id: cord-325377-g68onkjt
author: Dey, Anusree
title: COVID-19: Scientific Overview of the global Pandemic
date: 2020-10-28
extension: .txt
mime: text/plain
words: 1518
sentence: 54
flesch: 45
cache: cache/cord-325377-g68onkjt.txt
txt: txt/cord-325377-g68onkjt.txt
summary:
  A novel coronavirus from 290 patients with pneumonia in China Evolutionary Trajectory for the Emergence of 292 Novel Coronavirus SARS-CoV-2 A pneumonia outbreak 294 associated with a new coronavirus of probable bat origin COVID-19 Disease due to 296 SARS-CoV-2 (Novel Coronavirus) Clinical Characteristics 302 and Differential Clinical Diagnosis of Novel Coronavirus Disease Coronavirus Disease 2019 (COVID-19) Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Pathophysiological Comorbidity and its 309 impact on 1590 patients with COVID-19 in China: a nationwide analysis COVID-19) From Publicly Reported Confirmed 313 Cases: Estimation and Application Evidence Supporting Transmission of Severe 315 Acute Respiratory Syndrome Coronavirus 2 While Presymptomatic or Asymptomatic Receptor Recognition by the Novel 318 Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of 319 SARS Coronavirus COVID-19 infection: Origin The trinity of COVID-19: 323 immunity, inflammation and intervention Viral and host factors related to the 325 clinical outcome of COVID-19 Geographic and Genomic Distribution of SARS-CoV-2 An interpretable 329 mortality prediction model for COVID-19 patients Large 331 scale genomic analysis of 3067 SARS-CoV-2 genomes reveals a clonal geo-332 distribution and a rich genetic variations of hotspots mutations Cas12-based detection of SARS-CoV-2 Laboratory diagnosis of COVID-336 19: current issues and challenges Development and clinical application 338 of a rapid IgM IgG combined antibody test for SARS CoV 2 infection diagnosis Drug targets for 341 corona virus: According to the global data as well as the early estimates from China, both old 69 J o u r n a l P r e -p r o o f age and comorbidities may render the patients at higher risk of developing severe disease or 70 death due to COVID-19 infection, perhaps due to a weaker immune functioning [8, 10] .


id: cord-327063-ea7a1xfl
author: Dhama, Kuldeep
date: 2020-08-02
extension: .txt
mime: text/plain
words: 11075
sentence: 456
flesch: 42
cache: cache/cord-327063-ea7a1xfl.txt
txt: txt/cord-327063-ea7a1xfl.txt
title:
  SARS-CoV-2 jumping the species barrier: zoonotic lessons from SARS, MERS and recent advances to combat this pandemic virus

summary:
  CORONAVIRUS DISEASE 2019 UPDATE (22): COMPANION ANIMAL, DOG SUSPECTED, REQUEST FOR INFORMATION Infection of dogs with SARS-CoV-2 Coronavirus can infect cats -dogs, not so much First detection and genome sequencing of SARS-CoV-2 in an infected cat in France Virology: SARS virus infection of cats and ferrets Belgian cat infected by owner. key: cord-327063-ea7a1xfl authors: Dhama, Kuldeep; Patel, Shailesh Kumar; Sharun, Khan; Pathak, Mamta; Tiwari, Ruchi; Yatoo, Mohd Iqbal; Malik, Yashpal Singh; Sah, Ranjit; Rabaan, Ali A.; Panwar, Parmod Kumar; Singh, Karam Pal; Michalak, Izabela; Chaicumpa, Wanpen; Martinez-Pulgarin, Dayron F.; Bonilla-Aldana, D. Katterine; Rodriguez-Morales, Alfonso J. title: SARS-CoV-2 jumping the species barrier: zoonotic lessons from SARS, MERS and recent advances to combat this pandemic virus date: 2020-08-02 journal:


id: cord-345014-qp13h0un
author: Stein, Richard Albert
title: The 2019 coronavirus: Learning curves, lessons, and the weakest link
date: 2020-03-13
extension: .txt
mime: text/plain
words: 2282
sentence: 86
flesch: 46
cache: cache/cord-345014-qp13h0un.txt
txt: txt/cord-345014-qp13h0un.txt
summary:
  Here's what it's like in the isolated city Nonpharmaceutical measures for pandemic influenza in nonhealthcare settings-international travel-related measures The influenza pandemic of 1918-1919 in two remote island nations: Iceland and New Zealand Modeling the impact of air, sea, and land travel restrictions supplemented by other interventions on the emergence of a new influenza pandemic virus Quarantine for pandemic influenza control at the borders of small island nations Lessons from the history of quarantine, from plague to influenza A Design of non-pharmaceutical intervention strategies for pandemic influenza outbreaks Predicting support for non-pharmaceutical interventions during infectious outbreaks: a four region analysis Effectiveness of workplace social distancing measures in reducing influenza transmission: a systematic review Social measures may control pandemic flu better than drugs and vaccines Public health interventions and epidemic intensity during the 1918 influenza pandemic Fears are rising over the spread of China's deadly Wuhan virus, which has now reached the US. Pneumonia of unknown origin -China Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome Cross-species transmission of the newly identified coronavirus 2019-nCoV Reconstitution of the receptor-binding motif of the SARS coronavirus Receptor recognition and cross-species infections of SARS coronavirus ACE2 gene expression is up-regulated in the human failing heart A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus.


id: cord-304295-3mpymd8a
author: Khan, Muhammad Muzamil
title: Emergence of novel coronavirus and progress toward treatment and vaccine
date: 2020-06-04
extension: .txt
mime: text/plain
words: 2944
sentence: 128
flesch: 39
cache: cache/cord-304295-3mpymd8a.txt
txt: txt/cord-304295-3mpymd8a.txt
summary:
  It can inhibit chymotrypsin-like (3C-like) protease and has shown promising results against SARS coronavirus. Mild/Moderate 2019-nCoV Remdesivir RCT Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Approved antiviral drugs over the past 50 years Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from Effect of chloroquine on the growth of animal viruses In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine An evaluation of chloroquine as a broad-acting antiviral against hand, foot and mouth disease FDA-approved drug, prevents Zika virus infection and its associated congenital microcephaly in mice Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Dose refinements in long-term therapy of rheumatoid arthritis with antimalarials Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies Discovering drugs to treat coronavirus disease 2019 (COVID-19) Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8 Cutting edge: antimalarial drugs inhibit IFN-β production through blockade of cyclic GMP-AMP synthase-DNA interaction Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferongamma production by peripheral blood mononuclear cells In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro Emerging coronaviruses: genome structure, replication, and pathogenesis Flavonoids: an overview Flavonoids from Pterogyne nitens inhibit hepatitis C virus entry Inhibition of SARS-CoV 3CL protease by flavonoids


id: cord-315619-gowtohr8
author: Cox, Rebecca C.
date: 2020-09-22
extension: .txt
mime: text/plain
words: 4272
sentence: 159
flesch: 39
cache: cache/cord-315619-gowtohr8.txt
txt: txt/cord-315619-gowtohr8.txt
title:
  Pre-pandemic disgust proneness predicts increased coronavirus anxiety and safety behaviors: Evidence for a diathesis-stress model

summary:
  It was hypothesized that pre-pandemic disgust proneness would predict increases in coronavirus anxiety and safety behaviors during the pandemic, and those with high current perceived stress and high disgust proneness 4 years prior to the pandemic would report the highest coronavirus anxiety and safety behaviors. When number of COVID-19 cases by state and pre-pandemic disgust proneness were included in the model, pre-pandemic disgust proneness predicted a small increase in coronavirus safety behaviors, B = .27,  = .19, p <


id: cord-322980-rembksdr
author: Talwar, Shivangi
title: Ayurveda and Allopathic Therapeutic Strategies in Coronavirus Pandemic Treatment 2020
date: 2020-10-22
extension: .txt
mime: text/plain
words: 4546
sentence: 180
flesch: 42
cache: cache/cord-322980-rembksdr.txt
txt: txt/cord-322980-rembksdr.txt
summary:
  Therefore, Arsenicum album may be considered as a suitable remedy for COVID-19 treatment. This short review summarizes the role of allopathic and Ayurveda in coronavirus infections.


id: cord-344217-kci4uw7u
author: Majid, Sabhiya
date: 2020-08-25
extension: .txt
mime: text/plain
words: 5657
sentence: 228
flesch: 39
cache: cache/cord-344217-kci4uw7u.txt
txt: txt/cord-344217-kci4uw7u.txt
title:
  Managing the COVID-19 Pandemic: Research Strategies Based on the Evolutionary and Molecular Characteristics of Coronaviruses

summary:
  mSphere Multibasic cleavage site in the spike protein of SARS-CoV-2 is essential for infection of human lung cells Structure of SARS coronavirus spike receptor binding domain complexed with the receptor Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4 The bittersweet promise of glycobiology The novel coronavirus2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Human coronavirus NL63employs the severe acute respiratory syndrome coronavirus receptor for cellular entry ACE2 of the heart: from angiotensin I to angiotensin (1-7) Identification of a coronavirus hemagglutinin-esterase with a substrate specificity different from those of influenza C virus and bovine coronavirus COVID-19 infection: origin, transmission, and characteristics of human coronaviruses Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China The Association of Cardiovascular Diseases and Diabetes Mellitus with COVID-19 (SARS-CoV-2) and their possible mechanisms Crystal structure of NL63 respiratory coronavirus receptor-binding complexed with its human receptor Structural basis of receptor recognition by SARS-CoV-2 Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with ACE Clinical management of adult coronavirus infection disease 2019 (COVID-19) positive in the setting of low and medium intensity of care: a short practical review Master regulator analysis of the SARS-CoV-2 /human interactome COVID-19 outbreak: an update on therapeutic options Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations SN Compr Clin Med Cryo-electron tomography of mouse hepatitis virus: insights into the structure of the coronavirion The molecular biology of coronaviruses Coronavirus: organization, replication and expression of genome Mechanisms and enzymes involved in SARS coronavirus genome expression Pre-fusion structure of a human coronavirus spike protein The M, E, and N structural proteins of the severe acute respiratory syndrome coronavirus are required for efficient assembly, trafficking, and release of virus-like particles


id: cord-325700-f102uk2m
author: Fraser, Douglas D.
date: 2020-10-21
extension: .txt
mime: text/plain
words: 5712
sentence: 221
flesch: 33
cache: cache/cord-325700-f102uk2m.txt
txt: txt/cord-325700-f102uk2m.txt
title:
  Metabolomics Profiling of Critically Ill Coronavirus Disease 2019 Patients: Identification of Diagnostic and Prognostic Biomarkers

summary:
  Although plasma kynurenine effectively discriminated COVID19+ patients from healthy control subjects, determination of COVID19 status in ICU patients required further specificity that was optimally provided by an arginine/kynurenine ratio. None. MEASUREMENTS AND MAIN RESULTS: Age- and sex-matched healthy controls and ICU patients that were either coronavirus disease 2019 positive or coronavirus disease 2019 negative were enrolled.


id: cord-352985-5ccrkfsa
author: Putter, Jeffrey S.
date: 2020-09-04
extension: .txt
mime: text/plain
words: 2138
sentence: 83
flesch: 34
cache: cache/cord-352985-5ccrkfsa.txt
txt: txt/cord-352985-5ccrkfsa.txt
title:
  An Update on COVID-19 Infection Control Measures, Plasma-Based Therapeutics, Corticosteroid Pharmacotherapy and Vaccine Research

summary:
  Transfus Apher Sci DOI: 10.1016/j.transci.2020.102934 sha: doc_id: 352985 cord_uid: 5ccrkfsa This communication provides a compilation on aspects of COVID-19 infection control measures, describes the potential role of therapeutic plasma exchange to reduce fatality rates, addresses precautions concerning dexamethasone pharmacotherapy and updates the current status on the availability of vaccines. The early uses of therapeutic plasma exchange and low molecular weight heparin, for any clinical trial in development is warranted, in order to interdict the intense inflammatory/kinin driven cascade.


id: cord-293082-fw7deem8
author: Zhang, Guangzhi
title: Animal coronaviruses and SARS‐CoV‐2
date: 2020-08-16
extension: .txt
mime: text/plain
words: 2077
sentence: 54
flesch: 22
cache: cache/cord-293082-fw7deem8.txt
txt: txt/cord-293082-fw7deem8.txt
summary:
  All rights reserved of SARS-CoV-2 Genetic diversity and selection regulates evolution of infectious bronchitis virus Structural basis for human coronavirus attachment to sialic acid receptors Mutational analysis of aminopeptidase N, a receptor for several group 1 coronaviruses, identifies key determinants of viral host range Early death after feline infectious peritonitis virus challenge due to recombinant vaccinia virus immunization Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses Pathogenic characteristics of persistent feline enteric coronavirus infection in cats Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry Development of an Inactivated Vaccine Candidate SARS-CoV-2 invades host cells via a novel route: CD147-spike protein Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape Emerging and re-emerging coronaviruses in pigs As for the receptors utilized by SARS-CoV-2, biophysical and structural data showed that the S 374 protein engages with ACE2 with at least 10 times higher affinity compared to that of SARS-CoV 375 (Wrapp et al. 2020 ).


id: cord-352379-q5inrxcm
author: Lai, Michael M. C.
title: SARS virus: The beginning of the unraveling of a new coronavirus
date: 2003-10-17
extension: .txt
mime: text/plain
words: 7005
sentence: 319
flesch: 45
cache: cache/cord-352379-q5inrxcm.txt
txt: txt/cord-352379-q5inrxcm.txt
summary:
  key: cord-352379-q5inrxcm authors: Lai, Michael M. C. title: SARS virus: The beginning of the unraveling of a new coronavirus date: 2003-10-17 journal: J Biomed Sci DOI: 10.1007/bf02256318 sha: doc_id: 352379 cord_uid: q5inrxcm Severe acute respiratory syndrome (SARS) virus caused a severe outbreak in several regions of the world in 2003. The comparative studies of other coronaviruses offer insights into the understanding of SARS virus.


id: cord-318492-uu1p1rgi
author: Mansueto, Gelsomina
title: COVID-19: Brief Check Point Through The Pathologist's Eye (autopsy archive)
date: 2020-08-28
extension: .txt
mime: text/plain
words: 1973
sentence: 63
flesch: 29
cache: cache/cord-318492-uu1p1rgi.txt
txt: txt/cord-318492-uu1p1rgi.txt
summary:
  The test is primarily used to detect SARS-CoV-2 and to distinguish it from other viral agents responsible for similar types of pneumonia. This shows that although Sars-CoV-2 has high virulence, it behaves like other viruses, that in the population the symptoms occur in subjects often with comorbidities and that deaths are due to complications in the same way as it happens for other viral agents.


id: cord-343001-a6xrs0jy
author: Sahu, Kamal Kant
title: Novel coronavirus (2019-nCoV): Update on 3rd Coronavirus Outbreak of 21st Century
date: 2020-03-03
extension: .txt
mime: text/plain
words: 574
sentence: 15
flesch: 35
cache: cache/cord-343001-a6xrs0jy.txt
txt: txt/cord-343001-a6xrs0jy.txt
summary:
  key: cord-343001-a6xrs0jy authors: Sahu, Kamal Kant; Mishra, Ajay Kumar; Lal, Amos title: Novel coronavirus (2019-nCoV): Update on 3rd Coronavirus Outbreak of 21st Century date: 2020-03-03 journal: QJM DOI: 10.1093/qjmed/hcaa081 sha: doc_id: 343001 cord_uid: a6xrs0jy nan Dear Editor, We read with great interest the recent article by Fang et al on novel coronavirus infection (2019-nCoV) published in February issue (1) . Interesting to note that as compared to previous coronavirus outbreaks, diarrhea is rarely reported with 2019-nCoV infection (8-10).


id: cord-331022-tek4u751
author: Sinderewicz, Emilia
title: Immune Response to COVID-19: Can We Benefit from the SARS-CoV and MERS-CoV Pandemic Experience?
date: 2020-09-09
extension: .txt
mime: text/plain
words: 8489
sentence: 326
flesch: 40
cache: cache/cord-331022-tek4u751.txt
txt: txt/cord-331022-tek4u751.txt
summary:
  A comparison of the content of proinflammatory Th1 and Th2 cytokines in the serum of SARS patients with healthy controls documented a significantly greater concentration of TNF-α, IL-6, IL-8, IL-10, and IL-12 in the early stage of the SARS-CoV infection [32, 40] . It has been documented that increased IL-6 concentration in plasma of SARS patients was significantly increased in severe cases, but not in convalescent or control subjects, suggesting a positive correlation between serum IL-6 level and disease severity [61] .


id: cord-326584-io2f52kn
author: Killeen, G.
date: 2020-04-20
extension: .txt
mime: text/plain
words: 8787
sentence: 277
flesch: 37
cache: cache/cord-326584-io2f52kn.txt
txt: txt/cord-326584-io2f52kn.txt
title:
  Why lockdown? Simplified arithmetic tools for decision-makers, health professionals, journalists and the general public to explore containment options for the novel coronavirus

summary:
  Note, however, that the expected failure of contact tracing, and indeed testing generally, is just one more good reason to contain national COVID-19 epidemics before they progress from emergencies (Figures 1 and 4) into outright catastrophes (Figure 2 ). . Here we present simplified arithmetic models of COVID-19 transmission, control and elimination in user-friendly Shiny and Excel formats that allow non-specialists to explore, query, critique and understand the containment decisions facing their country and the world at large.


id: cord-241146-j0qperwz
author: Lallie, Harjinder Singh
date: 2020-06-21
extension: .txt
mime: text/plain
words: 9941
sentence: 402
flesch: 46
cache: cache/cord-241146-j0qperwz.txt
txt: txt/cord-241146-j0qperwz.txt
title:
  Cyber Security in the Age of COVID-19: A Timeline and Analysis of Cyber-Crime and Cyber-Attacks during the Pandemic

summary:
  A Look at Fake FIFA World Cup-themed Lotteries and Giveaways Blackmailing and passwords leaks Compromised linkedin accounts used to send phishing links via private message and inmail 10 tips to help if you are worried about coronavirus Facing down the myriad threats tied to covid-19 Threat spotlight: Coronavirus-related phishing Protecting businesses against cyber threats during covid-19 and beyond Covid aid scams and dodgy 2020 A systematic approach toward description and classification of cybercrime incidents A cyber attack modeling and impact assessment framework A taxonomy and survey of intrusion detection system design techniques, network threats and datasets Extracting narrative timelines as temporal dependency structures Classification of cyber attacks in south africa Sony's nightmare before christmas: The 2014 north korean cyber attack on sony and lessons for us government actions in cyberspace Naming the coronavirus disease (COVID-19) and the virus that causes it Cybercrime -prosecution guidance Vietnamese threat actors apt32 targeting wuhan government and chinese ministry of emergency management in latest example of covid-19 related espionage Skype phishing attack targets remote workers' passwords Fake Coronavirus Tracking Apps Are Really Malware That Stalks You How to design browser security and privacy alerts Bayesian network models in cyber security: a systematic review Google Translate Coronavirus disease (COVID-19) pandemic Latest information on Coronavirus disease 2019 (COVID-19) Research on computer network attack modeling based on attack graph Who reports fivefold increase in cyber attacks, urges vigilance search (Accessed Municipal:massive computer attack at the town hall of marseille Cyber attack on easyjet, compromised the data of nine million customers An extended model of cybercrime investigations A taxonomy of operational cyber security risks A taxonomy of technical attribution techniques for cyber attacks A taxonomy of network threats and the effect of current datasets on intrusion detection systems Chapter 1: Cyberdependent crimes Cyber-enabled crimes -fraud and theft Research Reveals Hacker Tactics: Cybercriminals Use DDoS as Smokescreen for Other Attacks on Business From cybersecurity deception to manipulation and gratification through gamification Recent ransomware attacks define the malware's new age 2020 state of malware report Social engineering attacks and covid-19 Chinese hackers 'weaponize' coronavirus data for new cyber attack: Here's what they did Coronavirus email attacks evolving as outbreak spreads Coronavirus phishing Threat Intel:Cyber Attacks Leveraging the COVID-19/CoronaVirus Pandemic Hackers are using the coronavirus fear for phishing, please pay attention to prevention Take advantage of the fire! Companies and verticals at risk for cyber attacks The implications of the COVID-19 pandemic for cybercrime policing in Scotland: a rapid review of the evidence and future considerations, ser.


id: cord-355758-tk7eturq
author: Berrio, Alejandro
date: 2020-09-22
extension: .txt
mime: text/plain
words: 2181
sentence: 62
flesch: 28
cache: cache/cord-355758-tk7eturq.txt
txt: txt/cord-355758-tk7eturq.txt
title:
  Positive selection within the genomes of SARS-CoV-2 and other Coronaviruses independent of impact on protein function

summary:
  The first is Nsp4, which encodes a similarities to, but also notable differences from, that of SARS-Cov-2 (Fig 1) . In the case of Nsp4 protein, two nearly adjacent nonsynonymous substitutions at residues 380 430 and 382 occurred on the branch leading to SARS-CoV-2 ( Fig 3B) .


id: cord-312741-0au4nctt
author: Lin, Panpan
title: Coronavirus in human diseases: Mechanisms and advances in clinical treatment
date: 2020-10-01
extension: .txt
mime: text/plain
words: 14692
sentence: 507
flesch: 30
cache: cache/cord-312741-0au4nctt.txt
txt: txt/cord-312741-0au4nctt.txt
summary:
  The 9-kDa hydrophobic protein encoded at the 3' end of the porcine transmissible gastroenteritis coronavirus genome is membrane-associated Mouse hepatitis virus gene 5b protein is a new virion envelope protein Infectious bronchitis virus E protein is targeted to the Golgi complex and directs release of virus-like particles A comprehensive comparison of transmembrane domains reveals organelle-specific properties Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein Induction of apoptosis in murine coronavirus-infected cultured cells and demonstration of E protein as an apoptosis inducer Assembly of the coronavirus envelope: homotypic interactions between the M proteins SARS coronavirus E protein forms cation-selective ion channels Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E Bcl-xL inhibits T-cell apoptosis induced by expression of SARS coronavirus E protein in the absence of growth factors The transmembrane domain of the infectious bronchitis virus E protein is required for efficient virus release Biochemical evidence for the presence of mixed membrane topologies of the severe acute respiratory syndrome coronavirus envelope protein expressed in mammalian cells Role of the coronavirus E viroporin protein transmembrane domain in virus assembly Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis Heterologous gene expression from transmissible gastroenteritis virus replicon particles Generation of a replication-competent, propagation-deficient virus vector based on the transmissible gastroenteritis coronavirus genome The small envelope protein E is not essential for murine coronavirus replication A severe acute respiratory syndrome coronavirus that lacks the E gene is attenuated in vitro and in vivo Absence of E protein arrests transmissible gastroenteritis coronavirus maturation in the secretory pathway Characterization of severe acute respiratory syndrome coronavirus membrane protein Sequence and topology of a model intracellular membrane protein, E1 glycoprotein, from a coronavirus Genetic evidence for a structural interaction between the carboxy termini of the membrane and nucleocapsid proteins of mouse hepatitis virus The molecular biology of coronaviruses A structural analysis of M protein in coronavirus assembly and morphology Envelope glycoprotein interactions in coronavirus assembly Efficient assembly and release of SARS coronavirus-like particles by a heterologous expression system Coronaviruses: an overview of their replication and pathogenesis Nucleocapsidindependent assembly of coronavirus-like particles by co-expression of viral envelope protein genes Coronavirus pseudoparticles formed with recombinant M and E proteins induce alpha interferon synthesis by leukocytes The cytoplasmic tails of infectious bronchitis virus E and M proteins mediate their interaction The missing link in coronavirus assembly. syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization Identification of in vivointeracting domains of the murine coronavirus nucleocapsid protein Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication Oligomerization of the carboxyl terminal domain of the human coronavirus 229E nucleocapsid protein Solution structure of the c-terminal dimerization domain of SARS coronavirus nucleocapsid protein solved by the SAIL-NMR method High affinity interaction between nucleocapsid protein and leader/intergenic sequence of mouse hepatitis virus RNA The nucleocapsid protein of SARS coronavirus has a high binding affinity to the human cellular heterogeneous nuclear ribonucleoprotein A1 Theoretical aspects of virus capsid assembly Analysis of multimerization of the SARS coronavirus nucleocapsid protein Mass spectroscopic characterization of the coronavirus infectious bronchitis virus nucleoprotein and elucidation of the role of phosphorylation in RNA binding by using surface plasmon resonance Mapping of the coronavirus membrane protein domains involved in interaction with the spike protein Envelope protein palmitoylations are crucial for murine coronavirus assembly The hydrophobic domain of infectious bronchitis virus E protein alters the host secretory pathway and is important for release of infectious virus The coronavirus E protein: assembly and beyond Mouse hepatitis virus replicase proteins associate with two distinct populations of intracellular membranes The intracellular sites of early replication and budding of SARS-coronavirus Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer Glycan shield and epitope masking of a coronavirus spike protein observed by cryoelectron microscopy Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains A human homolog of angiotensin-converting enzyme.


id: cord-322908-e3gok0ot
author: Huang, Fangfang
title: A review of therapeutic agents and Chinese herbal medicines against SARS-COV-2 (COVID-19)
date: 2020-05-20
extension: .txt
mime: text/plain
words: 5067
sentence: 158
flesch: 28
cache: cache/cord-322908-e3gok0ot.txt
txt: txt/cord-322908-e3gok0ot.txt
summary:
  Analysis on the application of Traditional Chinese Medicine in the treatment of COVID-19 by suppressing cytokine storm One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute Ischemic Stroke Baicalin ameliorates oxidative apoptosis by restoring mitochondrial dynamics in the spleen of chickens via the opposite modulation of NF-kappaB and Nrf2/HO-1 signaling pathway during Mycoplasma gallisepticum infection In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds Inhibitory activities of baicalin against renin and angiotensin-converting enzyme Availability, Pharmaceutics, Security, Pharmacokinetics, and Pharmacological Activities of Patchouli Alcohol, Evid Based Complement Alternat Med Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis Inhibition effects of patchouli alcohol against influenza a virus through targeting cellular PI3K/Akt and ERK/MAPK signaling pathways Oral administration of patchouli alcohol isolated from Pogostemonis Herba augments protection against influenza viral infection in mice Novel extraction techniques and pharmaceutical activities of luteolin and its derivatives Therefore, it can be reasonably speculated that baicalin is one of the potential drugs for COVID-19 treatment.


id: cord-274802-7ioiwsd8
author: Varghese, Praveen Mathews
date: 2020-08-19
extension: .txt
mime: text/plain
words: 19710
sentence: 642
flesch: 31
cache: cache/cord-274802-7ioiwsd8.txt
txt: txt/cord-274802-7ioiwsd8.txt
title:
  Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies

summary:
  Unlike SARS, COVID-19 patients had the highest viral load near presentation, which could account for the fast-spreading nature of this epidemic. In a study involving COVID-19 patients in Hong Kong recorded high viral load on presentation with the onset of symptoms and also when the symptoms are mild (83) .


id: cord-352781-aqh9zxgh
author: El Homsi, Maria
title: Review of Chest CT Manifestations of COVID-19 Infection
date: 2020-06-07
extension: .txt
mime: text/plain
words: 3810
sentence: 166
flesch: 41
cache: cache/cord-352781-aqh9zxgh.txt
txt: txt/cord-352781-aqh9zxgh.txt
summary:
  Here, we review the pertinent clinical findings and the current published data describing chest CT findings in COVID-19 pneumonia, the diagnostic performance of CT for diagnosis, including differential diagnosis, as well the evolving role of imaging in this disease. In their statement, they also note that with further research, information gained from a baseline CT in COVID-19 patients may play an important role in predicting who will have poor outcomes or need ventilation.


id: cord-354536-c9v9kbw8
author: Han, Yan-Jie
title: Advances and challenges in the prevention and treatment of COVID-19
date: 2020-07-09
extension: .txt
mime: text/plain
words: 5277
sentence: 236
flesch: 41
cache: cache/cord-354536-c9v9kbw8.txt
txt: txt/cord-354536-c9v9kbw8.txt
summary:
  61, 62 Chloroquine phosphate can block virus infection by up-regulating the pH of endosomes, required low for virus-cell fusion, and inhibiting glycosylation of cellular receptors. 73 Blood-derived immunotherapy based on recovered patients can be used to treat infections including measles virus, Lhasa virus, SARS coronavirus and influenza A H5N1 virus.


id: cord-349099-s33nd9hz
author: Gaffney, Adam W.
title: Home Sick with Coronavirus Symptoms: a National Study, April–May 2020
date: 2020-09-10
extension: .txt
mime: text/plain
words: 1141
sentence: 42
flesch: 46
cache: cache/cord-349099-s33nd9hz.txt
txt: txt/cord-349099-s33nd9hz.txt
summary:
  29.2% of those out-sick with coronavirus symptoms were uninsured, vs. 8% in each comparison group; 36.2% were food insecure, vs. 7.5% among those working and 20.8% among those out-sick for non-coronavirus symptoms/disability. Finally, we observed an association between states' prevalence of coronavirus and being out-sick with coronavirus symptoms: 45.1% of Americans out-sick with coronavirus symptoms resided in a state in the top quartile of coronavirus prevalence, while only 15.2% lived in a bottom-quartile state.


id: cord-279255-v861kk0i
author: Dhama, Kuldeep
title: Coronavirus Disease 2019–COVID-19
date: 2020-06-24
extension: .txt
mime: text/plain
words: 23944
sentence: 827
flesch: 36
cache: cache/cord-279255-v861kk0i.txt
txt: txt/cord-279255-v861kk0i.txt
summary:
  Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein Animal models for SARS and MERS coronaviruses Recent advances in the vaccine development against Middle East respiratory syndromecoronavirus Virology: SARS virus infection of cats and ferrets A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in golden Syrian hamsters Animal models and vaccines for SARS-CoV infection Infection with MERS-CoV causes lethal pneumonia in the common marmoset Vaccines for the prevention against the threat of MERS-CoV Molecular basis of coronavirus virulence and vaccine development Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection Genetically engineering a susceptible mouse model for MERS-CoV-induced acute respiratory distress syndrome Prospects for a MERS-CoV spike vaccine A mouse model for MERS coronavirus-induced acute respiratory distress syndrome Replicative capacity of MERS coronavirus in livestock cell lines Entry of human coronavirus NL63 into the cell China's response to a novel coronavirus stands in stark contrast to the 2002 SARS outbreak response Novel coronavirus is putting the whole world on alert Early epidemiological analysis of the coronavirus disease 2019 outbreak based on crowdsourced data: a population-level observational study Estimation of the transmission risk of the 2019-nCoV and its implication for public health interventions The mental health of medical workers in Wuhan, China dealing with the 2019 novel coronavirus The progress of 2019 novel coronavirus (2019-nCoV) event in China Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study Response to the emerging novel coronavirus outbreak Potential for global spread of a novel coronavirus from China Novel coronavirus, poor quarantine, and the risk of pandemic Novel Coronavirus outbreak in Wuhan, China, 2020: intense surveillance is vital for preventing sustained transmission in new locations Risk for transportation of 2019 novel coronavirus disease from Wuhan to other cities in China Infections without borders: a new coronavirus in Wuhan, China An interactive web-based dashboard to track COVID-19 in real time Limiting spread of COVID-19 from cruise ships-lessons to be learnt from Japan Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records A case of 2019 novel coronavirus in a pregnant woman with preterm delivery Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study A pregnant woman with COVID-19 in Central America Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19). CEPI to fund three programmes to develop vaccines against the novel coronavirus, nCoV-2019 Moderna announces funding award from CEPI to accelerate development of messenger RNA (mRNA) vaccine against novel coronavirus Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms Treatment with interferon-␣2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics Potential antiviral therapeutics for 2019 novel coronavirus A novel coronavirus outbreak of global health concern Coronavirusesdrug discovery and therapeutic options Treatment with lopinavir/ritonavir or interferon-␤1b improves outcome of MERS-CoV infection in a nonhuman primate model of common Marmoset Treatment of Middle East respiratory syndrome with a combination of lopinavir-ritonavir and interferon-␤1b (MIRACLE trial): study protocol for a randomized controlled trial Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein Characterization of novel monoclonal antibodies against MERScoronavirus spike protein Crossneutralization of SARS coronavirus-specific antibodies against bat SARS-like coronaviruses New coronavirus threat galvanizes scientists Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody Cell-based antiviral screening against coronaviruses: developing virus-specific and broad-spectrum inhibitors Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection Potential interventions for novel coronavirus in China: a systemic review Human transbodies that interfere with the functions of Ebola virus VP35 protein in genome replication and transcription and innate immune antagonism Inhibitors of RAS might be a good choice for the therapy of COVID-19 pneumonia Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture


id: cord-336775-d4hi9myk
author: Kirtipal, Nikhil
date: 2020-08-13
extension: .txt
mime: text/plain
words: 8621
sentence: 237
flesch: 29
cache: cache/cord-336775-d4hi9myk.txt
txt: txt/cord-336775-d4hi9myk.txt
title:
  From SARS to SARS-CoV-2, insights on structure, pathogenicity and immunity aspects of pandemic human coronaviruses

summary:
  bat-SL-CoVZX45 and bat-SL-CoVZX2 from bats Zhou et al., 2020b) . (E), nucleocapsid (N) proteins, and hemagglutinin (HA), where S, M, and E proteins are embedded in viral envelop while N protein protects viral RNA genome located as core of virus ( Fig. 3 ) (Zhou et al., 2020b) .


id: cord-324198-b8f99z8r
author: Allam, Zaheer
date: 2020-07-24
extension: .txt
mime: text/plain
words: 6793
sentence: 183
flesch: 39
cache: cache/cord-324198-b8f99z8r.txt
txt: txt/cord-324198-b8f99z8r.txt
title:
  Underlining the Role of Data Science and Technology in Supporting Supply Chains, Political Stability and Health Networks During Pandemics

summary:
  All the data collected from these platforms and numerous others that are actively being used elsewhere across the globe would remain its usefulness, even post-COVID-19, but this will require a superior statistical modeling tools to manage the increasing magnitude of such data. This far, in the medical field, with such technologies, there is evidence that it is now possible to perform noninvasive surgeries that reduce fatalities and also reduce healing time for patients, and such have proven beneficial (Elrod, 2014) , especially during this period of COVID-19.


id: cord-352322-tsjwnvkk
author: Khamassi Khbou, Médiha
title: Coronaviruses in farm animals: Epidemiology and public health implications
date: 2020-09-25
extension: .txt
mime: text/plain
words: 8119
sentence: 226
flesch: 31
cache: cache/cord-352322-tsjwnvkk.txt
txt: txt/cord-352322-tsjwnvkk.txt
summary:
  Molecular evolutionary genetics analysis version 7.0 for bigger datasets Coronavirus: How a large RNA viral genome is replicated and transcribed First genome sequences of buffalo coronavirus from water buffaloes in Bangladesh Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits Porcine respiratory coronavirus: Molecular features and virus-host interactions Detection and phylogenetic analysis of porcine deltacoronavirus in Korean swine farms Causative agents and epidemiology of diarrhea in Korean native calves Structure, function, and evolution of coronavirus spike proteins Full-length genome sequence of porcine deltacoronavirus strain USA/IA/2014/8734 Complete genome sequence of a novel swine acute diarrhea syndrome coronavirus Susceptibility of chickens to porcine deltacoronavirus infection Mutation in spike protein cleavage site and pathogenesis of feline coronavirus Infectious bronchitis virus variants: Molecular analysis and pathogenicity investigation Bovine coronavirus in neonatal calf diarrhoea in Iran Role of transportation in spread of porcine epidemic diarrhea virus infection. Vector-Borne and Zoonotic Diseases Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections:


id: cord-321194-xi4zy5ow
author: Allam, Zaheer
date: 2020-07-24
extension: .txt
mime: text/plain
words: 17937
sentence: 583
flesch: 52
cache: cache/cord-321194-xi4zy5ow.txt
txt: txt/cord-321194-xi4zy5ow.txt
title:
  The Third 50 Days: A Detailed Chronological Timeline and Extensive Review of Literature Documenting the COVID-19 Pandemic From Day 100 to Day 150

summary:
  For instance, as of 28th, the total number of reported cases in Africa (35,676) was far much less than the total number of deaths (59,266) reported in the United States on the same day. By April 28, it became official that the number of COVID-19 infection cases had exceeded the 3 million (the WHO reported 2.95 million cases and 202,597 deaths) people and caused the death of over 211,000 people globally.


id: cord-349313-2gupfqnl
author: Martinez-Perez, Clara
title: Citation Network Analysis of the Novel Coronavirus Disease 2019 (COVID-19)
date: 2020-10-21
extension: .txt
mime: text/plain
words: 7155
sentence: 327
flesch: 48
cache: cache/cord-349313-2gupfqnl.txt
txt: txt/cord-349313-2gupfqnl.txt
summary:
  Alterations in the digestive system as a result of COVID-19 Blood clotting alterations in COVID-19 patients. It has been shown that digestive symptoms are common in COVID-19 patients.


id: cord-347289-3yi5tz04
author: Poon, L. . C.
date: 2020-06-01
extension: .txt
mime: text/plain
words: 8045
sentence: 300
flesch: 35
cache: cache/cord-347289-3yi5tz04.txt
txt: txt/cord-347289-3yi5tz04.txt
title:
  ISUOG Interim Guidance on coronavirus disease 2019 (COVID‐19) during pregnancy and puerperium: information for healthcare professionals – an update

summary:
  Although not yet validated in COVID-19 pregnant patients, a modified early obstetric warning score (MEOWS) can be used to enable early recognition of critical illness 50, 51 . Miscarried embryos/fetuses and placentae of COVID-19 pregnant women should be treated as infectious tissues and should be disposed of appropriately.


id: cord-337825-ujq9mxk7
author: Chen, Bin
title: Overview of lethal human coronaviruses
date: 2020-06-10
extension: .txt
mime: text/plain
words: 13457
sentence: 535
flesch: 43
cache: cache/cord-337825-ujq9mxk7.txt
txt: txt/cord-337825-ujq9mxk7.txt
summary:
  lung injury Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patients Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14 +CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus Characterization of novel monoclonal antibodies against MERScoronavirus spike protein Discovery of hydrocarbon-stapled short α-helical peptides as promising Middle East respiratory syndrome coronavirus (MERS-CoV) fusion inhibitors A systematic review of therapeutic agents for the treatment of the Middle East respiratory syndrome coronavirus (MERS-CoV) Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay Current treatment options and the role of peptides as potential therapeutic components for Middle East respiratory syndrome (MERS): a review Cell therapy in acute respiratory distress syndrome Challenges and responses in human vaccine development Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine Expression of B subunit of E. coli heat-labile enterotoxin in the progenies of transgenic tobacco bred by crossing nuclear-and chloroplast-transgenic lines Immunogenicity of an adenoviral-based Middle East respiratory syndrome coronavirus vaccine in BALB/c mice One-Health: a safe, efficient, dual-use vaccine for humans and animals against Middle East respiratory syndrome coronavirus and rabies virus Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation DNA vaccine of SARS-Cov S gene induces antibody response in mice ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments-the importance of immunofocusing in subunit vaccine design Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody An emerging role of dipeptidyl peptidase 4 (DPP4) beyond glucose control: potential implications in cardiovascular disease Structural modeling of 2019-novel coronavirus (nCoV) spike protein reveals a proteolytically-sensitive activation loop as a distinguishing feature compared to SARS-CoV and related SARS-like coronaviruses Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV Disulfiram can inhibit MERS and SARS coronaviruspapain-like proteases via different modes De novo design of α-helical lipopeptides targeting viral fusion proteins: a promising strategy for relatively broad-spectrum antiviral drug discovery Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor New vaccine technologies to combat outbreak situations Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial Potent binding of 2019 novelcoronavirus spike protein by a SARS coronavirus-specific human monoclonalantibody Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies Exceptionally potent neutralizationof Middle East respiratory syndrome coronavirus by human monoclonalantibodies Interaction between heptad repeat 1 and 2 regions inspike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors Fusion mechanism of 2019-nCoV andfusion inhibitors targeting HR1 domain in spike protein The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (Grant No. 31870836), and the 1.3.5 Project for Disciplines Excellence, West China Hospital, Sichuan University (ZYYC20005 to W.C.). Epidemiology, genetic recombination, and pathogenesis of coronaviruses Origins and evolution of the global RNA virome Classify viruses-the gain is worth the pain Detection of a group 2 coronavirus in dogs with canine infectious respiratory disease Human coronaviruses: what do they cause? Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS A pneumonia outbreak associated with a new coronavirus of probable bat origin Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV On the origin and continuing evolution of SARS-CoV-2 Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Mutations, recombination and insertion in the evolution of 2019-nCoV SARS and MERS: recent insights into emerging coronaviruses Global epidemiology of bat coronaviruses From SARS to MERS, thrusting coronaviruses into the spotlight Challenges presented by MERS corona virus, and SARS corona virus to global health Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease MERS-CoV as an emerging respiratory illness: a review of prevention methods The Middle East respiratory syndrome (MERS)


id: cord-355238-wl53z9l7
author: Putrino, Alessandra
date: 2020-07-10
extension: .txt
mime: text/plain
words: 5433
sentence: 218
flesch: 47
cache: cache/cord-355238-wl53z9l7.txt
txt: txt/cord-355238-wl53z9l7.txt
title:
  Coronavirus (COVID-19) in Italy: knowledge, management of patients and clinical experience of Italian dentists during the spread of contagion

summary:
  Scientific bases for the development of questions about the new coronavirus came from consultation of the scientific literature available on this subject, more specifically addressed to virologists, specialists, biologists, and general practitioners and epidemiological content that traced the data on coronavirus infection since its first appearance in China [2] [3] [4] [5] According to the clinicians who participated in the study, the majority of patients (more than 61%) would not be worried about getting coronavirus infection during dental treatment.


id: cord-326017-qw4qynqv
author: Laskar, Partha
date: 2020-08-06
extension: .txt
mime: text/plain
words: 14817
sentence: 566
flesch: 35
cache: cache/cord-326017-qw4qynqv.txt
txt: txt/cord-326017-qw4qynqv.txt
title:
  “Tomorrow Never Dies”: Recent Advances in Diagnosis, Treatment, and Prevention Modalities against Coronavirus (COVID-19) amid Controversies

summary:
  Thus, early, rapid, and accurate diagnosis of COVID-19 patients is becoming very crucial to control the sources of infection and to prevent further community spread. Such tests have proven lung histology (lung damage or holes/honeycomb-like appearance) of COVID-19 patients [70] .


id: cord-353484-q7d0ysbo
author: Liu, Xue
title: COVID-19: Progress in diagnostics, therapy and vaccination
date: 2020-06-19
extension: .txt
mime: text/plain
words: 8584
sentence: 316
flesch: 33
cache: cache/cord-353484-q7d0ysbo.txt
txt: txt/cord-353484-q7d0ysbo.txt
summary:
  medRxiv Coronaviruses -drug discovery and therapeutic options Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro First Case of 2019 Novel Coronavirus in the United States Compassionate Use of Remdesivir for Patients with Severe Covid-19 Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial Effects of chloroquine on viral infections: an old drug against today's diseases? Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies Treating COVID-19 with Chloroquine Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial Comparative efficacy and safety of second-line antiretroviral therapy for treatment of HIV/AIDS: a systematic review and network meta-analysis Optimizing use of theranostic nanoparticles as a life-saving strategy for treating COVID-19 patients Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Consideration of highly active antiretroviral therapy in the prevention and treatment of severe acute respiratory syndrome Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase A phase 1/2 trial to evaluate the pharmacokinetics, safety, and efficacy of NI-03 in patients with chronic pancreatitis: study protocol for a randomized controlled trial on the assessment of camostat treatment in chronic pancreatitis (TACTIC) Experimental drugs poised for use in Ebola outbreak Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir Chloroquine is a potent inhibitor of SARS coronavirus infection and spread SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and Other Drugs for the Treatment of the New Coronavirus Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study. Revised 18 Engineering DNA vaccines against infectious diseases Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial Immunogenicity of a DNA vaccine candidate for COVID-19 Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques Safety of trivalent inactivated influenza vaccines in adults: background for pandemic influenza vaccine safety monitoring Inactivated poliovirus vaccine: past and present experience Safety and Immunogenicity Study of Inactivated Vaccine for Prophylaxis of SARS CoV-2 Infection (COVID-19) Novavax Initiates Phase 1/2 Clinical Trial of COVID-19 Vaccine.


id: cord-324324-8ybfiz8f
author: Decaro, Nicola
title: Novel human coronavirus (SARS-CoV-2): A lesson from animal coronaviruses
date: 2020-04-14
extension: .txt
mime: text/plain
words: 14950
sentence: 415
flesch: 34
cache: cache/cord-324324-8ybfiz8f.txt
txt: txt/cord-324324-8ybfiz8f.txt
summary:
  After 2002-2003 SARS epidemic, the renovated interest in HCoVs allowed the discovery of two additional viruses, the alphacoronavirus HCoV-NL63 and the betacoronavirus HCoV-HKU1, derived from bats and rodents, respectively (Tao et al., 2017) . NL63 (Tao et al., 2017) .


id: cord-305422-t8azymo7
author: Yi, Ye
title: COVID-19: what has been learned and to be learned about the novel coronavirus disease
date: 2020-03-15
extension: .txt
mime: text/plain
words: 8317
sentence: 339
flesch: 47
cache: cache/cord-305422-t8azymo7.txt
txt: txt/cord-305422-t8azymo7.txt
summary:
  In SARS patients, it has been demonstrated that fever (99%-100%), dry cough (29%-75%), dyspnea (40%-42%), diarrhea (20-25%), and sore throat (13-25%) were the major symptoms and ventilation support was required for approximately 14%-20% of the patients [45] . Cardiac events were also the main reason for death in SARS patients [55, 65, 99] .


id: cord-343021-gqem6bxj
author: Allam, Zaheer
date: 2020-07-24
extension: .txt
mime: text/plain
words: 6026
sentence: 171
flesch: 42
cache: cache/cord-343021-gqem6bxj.txt
txt: txt/cord-343021-gqem6bxj.txt
title:
  Oil, Health Equipment, and Trade: Revisiting Political Economy and International Relations During the COVID-19 Pandemic

summary:
  Similar measures have been advanced in different other countries, which adds to the protectionism shown through border restrictions and banning of flights and exportation of medical supplies. Other countries imposed nationwide lockdowns and curfews, only exempting essential service providers.


id: cord-349287-mwj2qby4
author: Mackay, Ian M.
title: MERS coronavirus: diagnostics, epidemiology and transmission
date: 2015-12-22
extension: .txt
mime: text/plain
words: 14293
sentence: 570
flesch: 47
cache: cache/cord-349287-mwj2qby4.txt
txt: txt/cord-349287-mwj2qby4.txt
summary:
  There are human MERS cases that do not fall into either category of source and it is unclear if these acquired infection through some entirely separate route, or from cases that escaped diagnosis. However, on occasion, even LRT specimens from MERS cases may initially be negative, only to later become positive by RT-PCR [95] .


id: cord-352230-8mazd3eu
author: Beeraka, Narasimha M.
title: Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors—The Current Status
date: 2020-09-18
extension: .txt
mime: text/plain
words: 9423
sentence: 274
flesch: 23
cache: cache/cord-352230-8mazd3eu.txt
txt: txt/cord-352230-8mazd3eu.txt
summary:
  A second, non-canonical RNA-dependent RNA polymerase in SARS Coronavirus Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins Molecular cloning, expression, and purification of SARS-CoV nsp13 Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase Inhibition of SARS coronavirus helicase by bismuth complexes Bismuth complexes inhibit the SARS coronavirus Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model Interferon alfacon 1 inhibits SARS-CoV infection in human bronchial epithelial Calu-3 cells A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models Nonstructural proteins 7 and 8 of feline coronavirus form a 2: 1 heterotrimer that exhibits primer-independent RNA polymerase activity New nsp8 isoform suggests mechanism for tuning viral RNA synthesis Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies A trial of lopinavirritonavir in adults hospitalized with severe Covid-19 The proximal origin of SARS-CoV-2 Trypsin treatment unlocks barrier for zoonotic bat coronavirus infection Twoyear prospective study of the humoral immune response of patients with severe acute respiratory syndrome Hydrolysis of biological peptides by human angiotensinconverting enzyme-related carboxypeptidase Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism ACE2: from vasopeptidase to SARS virus receptor Structure-based pharmacophore design and virtual screening for novel angiotensin converting enzyme 2 inhibitors Role of the ACE2/angiotensin 1-7 axis of the renin-angiotensin system in heart failure Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function Clinical characteristics of coronavirus disease 2019 in China Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission Hypothesis: angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may increase the risk of severe COVID-19 Evaluation of interferon inducers, ribavirin and mouse hyperimmune serum in a pathogenesis/lethal mouse model using a mouse-adapted SARS-CoV Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin Is the anti-psychotic, 10-(3-(dimethylamino) propyl) phenothiazine (promazine), a potential drug with which to treat SARS infections?: The molecular biology of SARS coronavirus An overall picture of SARS coronavirus (SARS-CoV) genome-encoded major proteins: structures, functions and drug development M and N proteins of SARS coronavirus induce apoptosis in HPF cells The SARS-Coronavirus Membrane protein induces apoptosis through modulating the Akt survival pathway Ribonucleocapsid formation of severe acute respiratory syndrome coronavirus through molecular action of the N-terminal domain of N protein Structure of the SARS coronavirus nucleocapsid protein RNA-binding dimerization domain suggests a mechanism for helical packaging of viral RNA Severe acute respiratory syndrome coronavirus 7a accessory protein is a viral structural protein SARS coronavirus 7a protein blocks cell cycle progression at G0/G1 phase via the cyclin D3/pRb pathway SARS coronavirus protein 7a interacts with human Ap 4 A-hydrolase Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque siRNA targeting the leader sequence of SARS-CoV inhibits virus replication Inhibition of genes expression of SARS coronavirus by synthetic small interfering RNAs Inhibition of severe acute respiratory syndrome virus replication by small interfering RNAs in mammalian cells Inhibition of SARS-CoV replication by siRNA Prophylactic and therapeutic effects of small interfering RNA targeting SARS coronavirus Screening of drugs by FRET analysis identifies inhibitors of SARS-CoV 3CL protease Recent developments in anti-severe acute respiratory syndrome coronavirus chemotherapy Deubiquitinating activity of the SARS-CoV papain-like protease Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease Drug design targeting the main protease, the Achilles' heel of coronaviruses Characterization and inhibition of SARScoronavirus main protease Enzymatic activity of the SARS coronavirus main proteinase dimer


id: cord-315598-qwh72inx
author: Mendoza, Jose Luis Accini
date: 2020-10-06
extension: .txt
mime: text/plain
words: 69660
sentence: 2114
flesch: 31
cache: cache/cord-315598-qwh72inx.txt
txt: txt/cord-315598-qwh72inx.txt
title:
  ACTUALIZACION DE LA DECLARACIÓN DE CONSENSO EN MEDICINA CRITICA PARA LA ATENCIÓN MULTIDISCIPLINARIA DEL PACIENTE CON SOSPECHA O CONFIRMACIÓN DIAGNÓSTICA DE COVID-19

summary:
  y los que tienen menos probabilidades de beneficiarse (él «demasiado enfermo»), no prestan suficiente atención a las diferencias entre grupos en términos de la duración de los cuidados intensivos necesarios para lograr resultados. Se recomienda aplicar la escala SOFA al menos cada 48 horas sumado al criterio de fragilidad y años de vida saludables salvados estos criterios podrían ser válidos en pacientes con fallo terapéutico a las medidas óptimas y orientar decisiones de deescalamiento de medidas y de nivel de complejidad de atención cuando la demanda potencial supera la oferta (capacidad y capacidades), estas decisiones deben ser tomadas idealmente en junta médica.


id: cord-338189-j4hnldk4
author: Saadat, Saeida
title: Environmental perspective of COVID-19
date: 2020-08-01
extension: .txt
mime: text/plain
words: 3977
sentence: 159
flesch: 54
cache: cache/cord-338189-j4hnldk4.txt
txt: txt/cord-338189-j4hnldk4.txt
summary:
  For instance, in Hong Kong, where COVID-19 infection started in late January/2020 the medical wastes have already polluted the environment. Coronavirus disease 19 (COVID-19): implications for clinical dental care Presumed asymptomatic carrier transmission of COVID-19 Pneumonia of unknown aetiology in Wuhan, China: potential for international spread via commercial air travel Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: an evaluation of the evidence The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Comparison of air quality in some of the biggest cities around the world before the COVID-19 pandemic and while the lockdown Climate Affects Global Patterns of COVID-19 Early Outbreak Dynamics Coagulation disorders in coronavirus infected patients:


