# bib

id: cord-280629-vb0002nx
author: Liu, Kuan-Ting
date: 2008-05-31
extension: .txt
mime: text/plain
words: 2149
sentence: 105
flesch: 50
cache: cache/cord-280629-vb0002nx.txt
txt: txt/cord-280629-vb0002nx.txt
title:
  Characteristics of Febrile Patients with Normal White Blood Cell Counts and High C-Reactive Protein Levels in an Emergency Department

summary:
  Bedside procalcitonin and C-reactive protein tests in children with fever without localizing signs of infection seen in a referral center Correlation between serum interleukin 6 and C-reactive protein concentrations in patients with adenoviral respiratory infection C-reactive protein and erythrocyte sedimentation rate in differential diagnosis between infections and neoplastic fever in patients with solid tumours and lymphomas An analysis of interleukin-8, interleukin-6 and C-reactive protein serum concentrations to predict fever, gram-negative bacteremia and complicated infection in neutropenic cancer patients IL-1 beta and IL-6 plasma levels in neutropenic patients after onset of fever and correlation with the C-reactive protein (CRP) kinetic values Interleukin-6 and acute-phase protein concentrations in surgical intensive care unit patients: diagnostic signs in nosocomial infection Assessment of measuring circulating levels of interleukin-6, interleukin-8, C-reactive protein, soluble Fc gamma receptor type III, and mannose-binding protein in febrile children with cancer and neutropenia Fever, leucocytosis and C-reactive protein after open-heart surgery and their value in the diagnosis of postoperative infections The clinical usefulness of C-reactive protein measurements C-reactive protein as an indicator of sepsis C-reactive protein during chemotherapy for acute leukemia with special reference to non-infective causes of fever C-reactive protein and fever in neutropenic patients Serum C-reactive protein levels in disease C reactive protein in the evaluation of febrile illness C-reactive protein for detection and follow-up of bacterial and fungal infections in Value of C-reactive protein determination in the initial diagnostic evaluation of the febrile, neutropenic child with cancer Value of measurement of C-reactive protein in febrile patients with hematological malignancies C-reactive protein: a valuable aid for the management of febrile children with cancer and neutropenia Endotoxaemia and inflammatory mediators in febrile patients with haematological disease A prospective study of daily measurement of C-reactive protein in serum of adults with neutropenia Levels of C-reactive protein in patients with hematologic malignancies C reactive protein rapid assay techniques for monitoring resolution of infection in immunosuppressed patients Interleukin-6 and its relationship to C-reactive protein and fever in children with febrile neutropenia Acute phase reactants and risk of bacterial meningitis among febrile infants and children Usefulness of procalcitonin and C-reactive protein rapid tests for the management of children with urinary tract infection C-reactive protein in febrile children 1 to 36 months of age with clinically undetectable serious bacterial infection Systemic inflammatory response syndrome in the trauma intensive care unit: who is infected? 01234'#5 /012345 67819$:;<= It was not rare in febrile patients who visited the ED to have a high CRP level but normal WBC count.


id: cord-286544-ipmcqz8n
author: Cheng, Biao
title: Predictors of progression from moderate to severe COVID-19: a retrospective cohort
date: 2020-07-02
extension: .txt
mime: text/plain
words: 1984
sentence: 92
flesch: 48
cache: cache/cord-286544-ipmcqz8n.txt
txt: txt/cord-286544-ipmcqz8n.txt
summary:
  CONCLUSIONS: Higher levels of NLR and CRP at admission were associated with poor prognosis of moderate COVID-19 patients. However, randomized controlled trials (RCTs) are required to confirm the impact of drug treatment on moderate COVID-19 patients.


id: cord-340433-h86cufyp
author: Sahu, Bikash R
title: C-reactive protein: a promising biomarker for poor prognosis in COVID-19 infection
date: 2020-06-05
extension: .txt
mime: text/plain
words: 1368
sentence: 53
flesch: 34
cache: cache/cord-340433-h86cufyp.txt
txt: txt/cord-340433-h86cufyp.txt
summary:
  Based on these observations, various studies were carried out in COVID-19 patients hypothesizing CRP as one of the possible biomolecules linked with the death of the infected patients. retrospective study Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study COVID-19 in persons with haematological cancers Clinical Characteristics of Deceased Patients Infected with SARS-CoV-2 in Prognostic value of C-reactive protein in patients with COVID-19 Correction to: Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan Clinical features of 95 sequential hospitalised patients with novel coronavirus 2019 disease (COVID-19), the first UK cohort Clinicolaboratory study of 25 fatal cases of COVID-19 in Wuhan Clinical and laboratory predictors of in-hospital mortality in patients with COVID-19: a cohort study in Wuhan, China Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up Clinical Course and Outcomes of 344 Intensive Care Patients with COVID-19 Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease Clinical characteristics and outcomes of patients with severe covid-19 with diabetes Characteristics, treatment, outcomes and cause of death of invasively ventilated patients with COVID-19 of The clinical data from 19 critically ill patients with coronavirus disease 2019: a single-centered, retrospective, observational study Predictive factors for disease progression in hospitalized patients with coronavirus disease 2019 in Wuhan CRP level is elevated in COVID-19 patients.


id: cord-291140-8c8lsy8g
author: Yufei, Yan
date: 2020-08-17
extension: .txt
mime: text/plain
words: 2363
sentence: 100
flesch: 47
cache: cache/cord-291140-8c8lsy8g.txt
txt: txt/cord-291140-8c8lsy8g.txt
title:
  Utility of the neutrophil-to-lymphocyte ratio and C-reactive protein level for coronavirus disease 2019 (COVID-19)

summary:
  Clinical characteristics of coronavirus disease 2019 in China Role of neutrophil to lymphocyte and monocyte to lymphocyte ratios in the diagnosis of bacterial infection in patients with fever Neutrophil-to-lymphocyte ratio as a prognostic marker in infective endocarditis: in-hospital and long-term clinical results A manual of laboratory and diagnostic tests WHO: clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected Clinical manifestations, laboratory findings, and treatment outcomes of SARS patients Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Mechanisms of lymphocyte loss in SARS coronavirus infection Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are predictors of heart failure The role of the systemic inflammatory response in predicting outcomes in patients with operable cancer: systematic review and meta-analysis The neutrophillymphocyte count ratio in patients with community-acquired pneumonia Elevated CRP levels were also observed in COVID-19 patients [9] .


id: cord-353116-7t1prfkr
author: Bhargava, Ashish
title: Predictors for Severe COVID-19 Infection
date: 2020-05-30
extension: .txt
mime: text/plain
words: 2636
sentence: 134
flesch: 50
cache: cache/cord-353116-7t1prfkr.txt
txt: txt/cord-353116-7t1prfkr.txt
summary:
  Predictors for severe COVID-19 infection have not been well defined. Severe COVID-19 infection was noted in 74 (37.6%) patients, requiring intubation.


id: cord-330411-hg1cxcs7
author: Keddie, S.
title: Laboratory biomarkers associated with COVID-19 severity and management
date: 2020-10-22
extension: .txt
mime: text/plain
words: 2409
sentence: 93
flesch: 38
cache: cache/cord-330411-hg1cxcs7.txt
txt: txt/cord-330411-hg1cxcs7.txt
summary:
  Neurological cases had lower levels of COVID-19 disease severity markers, which may be accounted for in part by selection bias, where patients were hospitalised due to neurological disease with concurrent, less severe COVID-19 infection compared to those admitted primarily due to COVID-19 respiratory failure. This study comprehensively explored clinical disease features and routine laboratory tests against specialist cytokine biomarkers associated with COVID-19 disease and its complications, to address their association with disease severity, respiratory intervention and outcome.


id: cord-317605-s9vv7rw4
author: Zhou, Y.
title: A New Predictor of Disease Severity in Patients with COVID-19 in Wuhan, China
date: 2020-03-27
extension: .txt
mime: text/plain
words: 2939
sentence: 135
flesch: 53
cache: cache/cord-317605-s9vv7rw4.txt
txt: txt/cord-317605-s9vv7rw4.txt
summary:
  The outcomes of patients with severe pneumonia and those with non-severe pneumonia were compared using the Statistical Package for the Social Sciences (IBM Corp., Armonk, NY, USA) to explore clinical characteristics and risk factors. Results: A total of 377 patients diagnosed with COVID-19 were enrolled in this study, including 117 with severe pneumonia and 260 with non-severe pneumonia.


id: cord-348348-vt87zwfr
author: Semmekrot, B. A.
date: 2008
extension: .txt
mime: text/plain
words: 3012
sentence: 157
flesch: 42
cache: cache/cord-348348-vt87zwfr.txt
txt: txt/cord-348348-vt87zwfr.txt
title:
  Vermindering van diagnostiek en overbehandeling bij RS-virus-bronchiolitis na geprotocolleerde behandeling

summary:
  Wij vonden geen significante invloed van het maken van een thoraxfoto en het op basis hiervan geven van antibiotica op de opnameduur, dit kwam overeen met een eerdere studie. We wilden vooral weten wat de invloed is van het verrichten van CRP en X-thorax op het verstrekken van antibiotica.


id: cord-000753-gowyfu55
author: Kafkas, Nikolaos
date: 2012-09-04
extension: .txt
mime: text/plain
words: 3232
sentence: 133
flesch: 39
cache: cache/cord-000753-gowyfu55.txt
txt: txt/cord-000753-gowyfu55.txt
title:
  Serum Levels of Gelatinase Associated Lipocalin as Indicator of the Inflammatory Status in Coronary Artery Disease

summary:
  Increase in serum NGAL resulting from activation of neutrophils may reflect an acute systemic inflammatory response to events such as stroke, renal failure, or infection As far as the gradual increase of serum-NGAL, according to the seriousness of unstable coronary clinical syndrome, this could reflect the intensity of the inflammatory reaction, as it is expressed by the incremental increase of hs-CRP and neutrophil count and their combination with serum NGAL.


id: cord-258108-l9nzq9rv
author: Kim, Hwan Soo
title: Pentraxin 3 as a clinical marker in children with lower respiratory tract infection
date: 2015-04-01
extension: .txt
mime: text/plain
words: 3301
sentence: 149
flesch: 45
cache: cache/cord-258108-l9nzq9rv.txt
txt: txt/cord-258108-l9nzq9rv.txt
summary:
  PTX-3 levels showed a significant correlation with PCT levels, but not with the levels of CRP (Table 3) . To compare PTX-3 levels in different types of viral infection, the Mann-Whitney U-test was performed for continuous variables that did not follow a parametric distribution, and the Wilcoxon signed-ranks test was used to compare categorical variables.


id: cord-297093-ld89vmct
author: Clark, Kristina E N
title: Safety of intravenous Anakinra in COVID-19 with evidence of hyperinflammation, a case series
date: 2020-08-04
extension: .txt
mime: text/plain
words: 3245
sentence: 152
flesch: 41
cache: cache/cord-297093-ld89vmct.txt
txt: txt/cord-297093-ld89vmct.txt
summary:
  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Clinical features of patients infected with 2019 novel coronavirus in Wuhan The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist Tocilizumab may be the key to reduce the mortality COVID-19: Immunology and treatment options Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients A Dynamic Immune Response Shapes COVID-19 Progression. Our aim is to report our experience on the beneficial effects of intravenous anakinra in patients with SARS-CoV-2 and evidence of hyperinflammation.


id: cord-348053-s0ijzyaq
author: Mueller, Alisa A.
title: Inflammatory biomarker trends predict respiratory decline in COVID-19 patients
date: 2020-10-29
extension: .txt
mime: text/plain
words: 3734
sentence: 143
flesch: 41
cache: cache/cord-348053-s0ijzyaq.txt
txt: txt/cord-348053-s0ijzyaq.txt
summary:
  Our work suggests that close, serial monitoring of early CRP values may aid clinical prognostication and consideration of immunomodulatory therapy in COVID-19 patients. Prior studies typically stratify COVID-19 patients into either noncritical or critical categories and do not distinguish patients that were critically ill at admission versus those patients that initially had non-critical illness and then deteriorated.


id: cord-277879-7ftu9b9q
author: Martinez-Sanz, J.
date: 2020-06-09
extension: .txt
mime: text/plain
words: 4021
sentence: 162
flesch: 39
cache: cache/cord-277879-7ftu9b9q.txt
txt: txt/cord-277879-7ftu9b9q.txt
title:
  Effects of Tocilizumab on Mortality in Hospitalized Patients with COVID-19: A Multicenter Cohort Study

summary:
  Tocilizumab targets the IL-6 receptor, and thus using baseline IL-6 levels instead of CRP in the interaction term with tocilizumab use could have helped to better discriminate the population benefiting most from tocilizumab treatment. 5 Tocilizumab is not currently approved for use by the FDA in COVID-19 patients.


id: cord-289832-092dtzrd
author: Villard, Orianne
date: 2020-07-21
extension: .txt
mime: text/plain
words: 3950
sentence: 152
flesch: 35
cache: cache/cord-289832-092dtzrd.txt
txt: txt/cord-289832-092dtzrd.txt
title:
  The Plasmatic Aldosterone and C-Reactive Protein Levels, and the Severity of Covid-19: The Dyhor-19 Study

summary:
  In univariate analyses, aldosterone levels at inclusion were significantly higher in patients with severe clinical course (OS ≥ 5) (median (min-max), 304.7 (102.5-1360.1) pmol/L) as compared to those with mild or moderate course (OS ≤ 4) (102.5 (102.5-540.2) pmol/L) (p < 0.01). At inclusion, aldosterone levels were not clearly associated with a specific clinical status (p = 0.61) (Figure 2A) .


id: cord-030277-x9zvx3fp
author: Ohta, Yoshinori
date: 2020-08-10
extension: .txt
mime: text/plain
words: 4083
sentence: 169
flesch: 47
cache: cache/cord-030277-x9zvx3fp.txt
txt: txt/cord-030277-x9zvx3fp.txt
title:
  Effect of dexmedetomidine on inflammation in patients with sepsis requiring mechanical ventilation: a sub-analysis of a multicenter randomized clinical trial

summary:
  The percentage of patients with three or more SIRS characteristics did not differ significantly between the DEX vs. non-DEX group (range, 12-71 vs. 19-74%; P = 0.15). The DESIRE trial was a multicenter randomized clinical trial in which adult patients with sepsis were sedated with (DEX group) or without (non-DEX group) dexmedetomidine while on mechanical ventilators.


id: cord-000268-480d3yfv
author: Porfyridis, Ilias
date: 2010-09-29
extension: .txt
mime: text/plain
words: 4277
sentence: 169
flesch: 39
cache: cache/cord-000268-480d3yfv.txt
txt: txt/cord-000268-480d3yfv.txt
title:
  Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: an observational study

summary:
  Imaging of pneumonia: trends and algorithms Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia TREM-1(triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses TREM-1 amplifies inflammation and is a crucial mediator of septic shock Does soluble triggering receptor expressed on myeloid cells-1 play any role in the pathogenesis of septic shock? Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia Serum of patients with septic shock stimulates the expression of Trem-1 on U937 monocytes Clinical review: Role of triggering receptor expressed on myeloid cells-1 during sepsis Triggering receptor expressed on myeloid cells-1 (TREM-1) is regulated post-transcriptionally and its ligand is present in the sera of some septic patients Soluble triggering receptor expressed on myeloid cells-1: a biomarker for bacterial meningitis Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis Triggering receptor expressed on myeloid cells-1 expression on monocytes is associated with inflammation but not with infection in acute pancreatitis Soluble triggering receptor expressed on myeloid cells-1(sTREM-1): a new mediator involved in the pathogenesis of peptic ulcer disease Role of soluble triggering receptor expressed on myeloid cells-1 in inflammatory bowel disease TREM-1 expression in tumor-associated macrophages and clinical outcome in lung cancer Activation of triggering receptor expressed on myeloid cells-1 on human neutrophils by Marburg and ebola viruses Soluble triggering receptor expressed on myeloid cells 1 is released in patients with stable chronic obstructive pulmonary disease Increased plasma levels of soluble triggering receptor expressed on myeloid cells 1 and procalcitonin after cardiac surgery and cardiac arrest without infection The increased expression of TREM-1 on monocytes is associated with infectious and non-infectious inflammatory processes Soluble TREM-1 is not suitable for distinguishing between systemic inflammatory response syndrome and sepsis survivors and nonsurvivors in the early stage of acute inflammation Prognosis of community acquired pneumonia(CAP): value of triggering receptor expressed on myeloid cells-1 (TREM-1) and other mediators of the inflammatory response Timecourse of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis Diagnosing pneumonia during mechanical ventilation: the clinical pulmonary infection score revisited Infectious Diseases Society of America Guidelines for the management of adult lower respiratory track infections Acute pulmonary embolism focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of chronic heart failure in adults: A Report of the American College of Cardiology Foundation European Respiratory Society international multidisciplinary consensus classification of idiopathic interstitial pneumonias Early changes of CD4-positive lymphocytes and NK cells in patients with severe Gram-negative sepsis The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network: Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome TREM and TREM-like receptors in inflammation and disease The TREM receptor family and signal integration Monocytes as a site of production of soluble triggering receptor expressed on myeloid cells -1(sTREM-1) in the septic host Soluble triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis Soluble triggering receptor expressed on myeloid cells-1 as an antiinflammatory mediator in sepsis Soluble triggering receptor expressed on myeloid cells -1 key: cord-000268-480d3yfv authors: Porfyridis, Ilias; Plachouras, Diamantis; Karagianni, Vasiliki; Kotanidou, Anastasia; Papiris, Spyridon A; Giamarellou, Helen; Giamarellos-Bourboulis, Evangelos J title: Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: an observational study date: 2010-09-29 journal: BMC Infect Dis DOI: 10.1186/1471-2334-10-286 sha: doc_id: 268 cord_uid: 480d3yfv BACKGROUND: Differential diagnosis of patients with lung infiltrates remains a challenge.


id: cord-343986-mneil7gn
author: Aronen, Matti
title: Respiratory tract virus infections in the elderly with pneumonia
date: 2019-04-16
extension: .txt
mime: text/plain
words: 4414
sentence: 185
flesch: 46
cache: cache/cord-343986-mneil7gn.txt
txt: txt/cord-343986-mneil7gn.txt
summary:
  What is the real role of respiratory viruses in severe community-acquired pneumonia? Evaluating the evidence for the implementation of C-reactive protein measurement in adult patients with suspected lower respiratory tract infection in primary care: a systematic review Biomarkers in lower respiratory tract infections Inflammatory parameters predict etiologic patterns but do not allow for individual prediction of etiology in patients with CAP: results from the German competence network CAPNETZ C-reactive protein mediating Immunopathological lesions: a potential treatment option for severe influenza a diseases Albumin and C-reactive protein have prognostic significance in patients with communityacquired pneumonia Diagnostic and prognostic value of interleukin-6 and C-reactive protein in communityacquired pneumonia Occurrence of respiratory virus: time, place and person The number of over 80-year-old patients with weaning immune system is rising rapidly in Western societies, but the clinical significance of respiratory virus infections among this group remains unclear.


id: cord-024631-yvek5vjz
author: Althaus, T.
date: 2020-05-11
extension: .txt
mime: text/plain
words: 4330
sentence: 164
flesch: 35
cache: cache/cord-024631-yvek5vjz.txt
txt: txt/cord-024631-yvek5vjz.txt
title:
  Causes of fever in primary care in Southeast Asia and the performance of C-reactive protein in discriminating bacterial from viral pathogens

summary:
  We thank all primary care patients and health workers from Chiang Rai primary care centres and Hlaing Tha Yar public hospital and MAM clinics for taking part in the study. C-reactive protein (CRP) is one of the most studied host-response biomarkers of bacterial infection, consistently showing high sensitivity and moderate specificity, and CRP POCTs have been shown to be cost-effective in resource-poor environments


id: cord-334047-xwjwt2be
author: Ruppert, Christoph
date: 2020-09-10
extension: .txt
mime: text/plain
words: 4752
sentence: 193
flesch: 46
cache: cache/cord-334047-xwjwt2be.txt
txt: txt/cord-334047-xwjwt2be.txt
title:
  Duplex Shiny app quantification of the sepsis biomarkers C-reactive protein and interleukin-6 in a fast quantum dot labeled lateral flow assay

summary:
  key: cord-334047-xwjwt2be authors: Ruppert, Christoph; Kaiser, Lars; Jacob, Lisa Johanna; Laufer, Stefan; Kohl, Matthias; Deigner, Hans-Peter title: Duplex Shiny app quantification of the sepsis biomarkers C-reactive protein and interleukin-6 in a fast quantum dot labeled lateral flow assay date: 2020-09-10 journal: J Nanobiotechnology DOI: 10.1186/s12951-020-00688-1 sha: doc_id: 334047 cord_uid: xwjwt2be Fast point-of-care (POC) diagnostics represent an unmet medical need and include applications such as lateral flow assays (LFAs) for the diagnosis of sepsis and consequences of cytokine storms and for the treatment of COVID-19 and other systemic, inflammatory events not caused by infection. Indeed, several other molecules, such as procalcitonin, are frequently described as potential biomarkers for sepsis [7, 14] and therefore may be included in further development of lateral flow assays, to increase the specificity of such point of care (POC) devices.


id: cord-347014-88zmtky7
author: Esposito, Susanna
date: 2016-11-15
extension: .txt
mime: text/plain
words: 5520
sentence: 206
flesch: 39
cache: cache/cord-347014-88zmtky7.txt
txt: txt/cord-347014-88zmtky7.txt
title:
  Sensitivity and Specificity of Soluble Triggering Receptor Expressed on Myeloid Cells-1, Midregional Proatrial Natriuretic Peptide and Midregional Proadrenomedullin for Distinguishing Etiology and to Assess Severity in Community-Acquired Pneumonia

summary:
  When PCT was considered, the cut-off values with the highest combined sensitivity and specificity were ≥0.188 ng/mL for bacterial CAP and ≤0.07 ng/mL for viral CAP. Furthermore, the differentiation of viral from bacterial CAP is necessary for the rational use of antibiotics and the consequent reduction in the emergence of bacterial resistance and drug-related adverse events [3] .


id: cord-004378-g1rxygef
author: Leinisch, Fabian
date: 2020-02-20
extension: .txt
mime: text/plain
words: 5850
sentence: 228
flesch: 48
cache: cache/cord-004378-g1rxygef.txt
txt: txt/cord-004378-g1rxygef.txt
title:
  UV oxidation of cyclic AMP receptor protein, a global bacterial gene regulator, decreases DNA binding and cleaves DNA at specific sites

summary:
  Recent advances in the analysis of oxidized proteins Persulfoxide: key intermediate in reactions of singlet oxygen with sulfides Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): unique resources for biological research Scanning calorimetric study of the thermal unfolding of catabolite activator protein from Escherichia coli in the absence and presence of cyclic mononucleotides Dissecting direct and indirect readout of cAMP receptor protein DNA binding using an inosine and 2,6-diaminopurine in vitro selection system Peroxyl radical-and photo-oxidation of glucose 6-phosphate dehydrogenase generates cross-links and functional changes via oxidation of tyrosine and tryptophan residues Quantification of protein modification by oxidants Structural and functional changes in RNAse Purified CRP protein was then dialyzed twice against 5 L dialysis buffer (50 mM sodium phosphate, 200 mM KCl, 5 mM β-mercaptoethanol, pH 8.0) and stored at −80 °C.


id: cord-256154-i6bs536s
author: Cheng, Chao-Wen
title: New markers in pneumonia
date: 2013-04-18
extension: .txt
mime: text/plain
words: 6399
sentence: 247
flesch: 33
cache: cache/cord-256154-i6bs536s.txt
txt: txt/cord-256154-i6bs536s.txt
summary:
  The common clinical symptoms of pneumonia patients include cough, fever, chills, fatigue, dyspnea, rigors, and pleuritic chest pain CRP was first identified in 1930 from the serum of pneumonia patients.


id: cord-103653-hgnz0fkv
author: Wyse, C.
date: 2020-10-27
extension: .txt
mime: text/plain
words: 6247
sentence: 216
flesch: 31
cache: cache/cord-103653-hgnz0fkv.txt
txt: txt/cord-103653-hgnz0fkv.txt
title:
  Seasonal and Daytime Variation in Multiple Immune Parameters in Humans: Evidence from 329,261 Participants of the UK Biobank Cohort

summary:
  Science (80-. ) Circadian Misalignment Increases C-Reactive Protein and Blood Pressure in Chronic Shift Workers Diurnal, seasonal, and blood-processing patterns in levels of circulating fibrinogen, fibrin D-dimer, Creactive protein, tissue plasminogen activator, and von Willebrand factor in a 45-yearold population Seasonal and Sex variation of high-sensitivity C-reactive protein in healthy adults: A longitudinal study Circadian clock proteins and immunity Seasonal Variations of Complete Blood Count and Inflammatory Biomarkers in the US Population -Analysis of NHANES Data Host and Environmental Factors Influencing Individual Human Cytokine Responses Seasonal variation in whole blood cytokine production after LPS stimulation in normal individuals Seasonal variation of C-reactive protein in apparently healthy Koreans Study of J / ψ Production in Jets Influenza Seasonality: Underlying Causes and Modeling Theories Human rhinovirus species and season of infection determine illness severity Epidemic influenza and vitamin D Serum 25-hydroxyvitamin D was not associated with influenza virus infection in children and adults in Hong Kong Shortcomings of vitamin Dbased model simulations of seasonal influenza Widespread seasonal gene expression reveals annual differences in human immunity and physiology Seasonal variation in host susceptibility and cycles of certain infectious diseases Time of day is represented by 2 linear splines, to account for non-linear relationships with the independent variables Data are expressed as regression coefficients (b), with 95% confidence intervals in parentheses. Seasonal patterns were evident in lymphocyte and neutrophil counts, and CRP, but not monocytes, and these were independent of lifestyle, demographic and environmental factors.


id: cord-297138-t8b3914h
author: Duijker, G.
date: 2015-04-02
extension: .txt
mime: text/plain
words: 6835
sentence: 256
flesch: 43
cache: cache/cord-297138-t8b3914h.txt
txt: txt/cord-297138-t8b3914h.txt
title:
  Reporting effectiveness of an extract of three traditional Cretan herbs on upper respiratory tract infection: Results from a double-blind randomized controlled trial

summary:
  The distributions of the daily WURSS-21 scores in virus-positive intervention and control group patients are depicted in Fig. Even in the sub-sample of virus positive patients, our sample was very heterogeneous as several types of viruses were identified.


id: cord-014516-r59usk02
title: Research Communications of the 24th ECVIM‐CA Congress
date: 2015-01-10
extension: .txt
mime: text/plain
words: 55086
sentence: 2641
flesch: 49
cache: cache/cord-014516-r59usk02.txt
txt: txt/cord-014516-r59usk02.txt
summary:
  Method specificity was confirmed by the absence of matrix effect in six serum specimen obtained from clinical dogs. Stage C dogs had lower SRs (p = 0.0005), higher SRe (p = 0.0029) and SRa (p = 0.0004) than other dogs.


id: cord-005727-li8pwigg
title: ESICM 2010 MONDAY SESSIONS 11 October 2010
date: 2010-08-31
extension: .txt
mime: text/plain
words: 102900
sentence: 5541
flesch: 50
cache: cache/cord-005727-li8pwigg.txt
txt: txt/cord-005727-li8pwigg.txt
summary:
  Postoperative sedation with both midazolam and dexmedetomidine were effective in suppressing oxidative stress in ICU patients. Poorly controlled pain in the postoperative period can lead to slow recovery and life threatening complications, especially in elderly patients. The use of a tidal volume of 6 ml/kg of predicted body weight is part of the management of patients presenting with ARDS (1) and prevents ventilator induced lung injury in ICU patients undergoing mechanical ventilation (2) .


id: cord-005497-w81ysjf9
date: 2020-03-24
extension: .txt
mime: text/plain
words: 103795
sentence: 5338
flesch: 50
cache: cache/cord-005497-w81ysjf9.txt
txt: txt/cord-005497-w81ysjf9.txt
title:
  40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020

summary:
  Conclusions: This is one of the first studies to demonstrate that abnormal RV function is associated with an increased mortality in ICU patients with pneumonia. The fast efficacy of targeted therapies led some intensivists to use them as rescue therapy for ICU patients.


id: cord-023157-0lqlx2rv
title: Poster Sessions
date: 2013-04-18
extension: .txt
mime: text/plain
words: 128609
sentence: 6093
flesch: 50
cache: cache/cord-023157-0lqlx2rv.txt
txt: txt/cord-023157-0lqlx2rv.txt
summary:
  Results: Mean values of WC, blood pressure (BP), fasting plasma glucose (FPG), triglycerides (TG), HDL-Cholesterol and BMI were significantly higher in men than in women who had higher %BF (28% vs. 21%). Results: During IvGTT GBP-pigs displayed lower glucose and higher insulin levels compared to controls.


id: cord-015021-pol2qm74
date: 1994
extension: .txt
mime: text/plain
words: 162543
sentence: 7248
flesch: 45
cache: cache/cord-015021-pol2qm74.txt
txt: txt/cord-015021-pol2qm74.txt
title:
  Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches

summary:
  Ever since we know the role of endotoxins in the pathophysiology of sepsis, antibodies against the S-and R-LPS have also been detected in sepsis patients. In sepsis patients, the CD]4+/CD16+ cells can become a major population with more than 50% of all monocytes in 3 of 18 patients and with more than 500 cells/mm 3 in 4 of 18 cases.


id: cord-015324-y44sfr0c
title: Scientific Programme
date: 2007-09-01
extension: .txt
mime: text/plain
words: 197844
sentence: 10138
flesch: 49
cache: cache/cord-015324-y44sfr0c.txt
txt: txt/cord-015324-y44sfr0c.txt
summary:
  In the group I, consisted of 63 infants (35 males and 28 females) PCD increased during the time in 3,2% infants, remained unchanged in 11,1%, decreased in 14,3%, and disappeared in 71,4% patients. There was no significant difference between renal transplant patients and healthy controls in genotype distribution of allelic frequencies of IL-6, FAS and MCP-1 polymorphisms.


# url

id: cord-340433-h86cufyp
domain: www.euro.who.int
url:
  http://www.euro.who.int/en/health-topics/health-emergencies/coronavirus-covid-19/news/news/2020/3/who-announces-covid-19-outbreak-a-pandemic)


# ent

id: cord-000268-480d3yfv
sid: 148
eid: 20
type: ORG
entity:
  the american college of cardiology foundation european respiratory society international multidisciplinary consensus classification


# pos

id: cord-340433-h86cufyp
sid: 15
tid: 11
pos: PROPN
token:
  http://www.euro.who.int/en/health-topics/health-emergencies/coronavirus-covid-19/news/news/2020/3/who-announces-covid-19-outbreak-a-pandemic

lemma:
  http://www.euro.who.int/en/health-topics/health-emergencies/coronavirus-covid-19/news/news/2020/3/who-announces-covid-19-outbreak-a-pandemic


