# bib

id: cord-344020-8poerd09
author: Vermeulen, Tom D
title: Autochthonous dengue in two Dutch tourists visiting Département Var, southern France, July 2020
date: 2020-10-01
extension: .txt
mime: text/plain
words: 1828
sentence: 87
flesch: 50
cache: cache/cord-344020-8poerd09.txt
txt: txt/cord-344020-8poerd09.txt
summary:
  Interestingly, one of her family members upon our clinical suspicion of dengue virus infection spontaneously acknowledged having seen tiger mosquitoes (Aedes albopictus) around their holiday home. Autochthonous DENV infection was first reported in France in 2010 and has since been reported at an almost yearly basis [12, 13] .


id: cord-307219-okvvajms
author: Lazzarini, Luca
title: First autochthonous dengue outbreak in Italy, August 2020
date: 2020-09-10
extension: .txt
mime: text/plain
words: 1888
sentence: 79
flesch: 51
cache: cache/cord-307219-okvvajms.txt
txt: txt/cord-307219-okvvajms.txt
summary:
  Between 2010 and 2019, autochthonous cases of dengue fever in Europe were reported in 2010 from France The surveillance, active between June and November, aims to increase the detection rate of DENV and CHIKV (since 2015, also ZIKV) infection in travellers from endemic areas and to promptly identify potential autochthonous cases.


id: cord-002085-e7xwb03g
author: Yamashita, Akifumi
title: DGV: Dengue Genographic Viewer
date: 2016-06-07
extension: .txt
mime: text/plain
words: 2457
sentence: 93
flesch: 40
cache: cache/cord-002085-e7xwb03g.txt
txt: txt/cord-002085-e7xwb03g.txt
summary:
  Here, we constructed the website Dengue Genographic Viewer (DGV), which presents DENV information based on the genotype and epidemiological data by using the geographic tool Google Maps © to update the recent dissemination of DENV genotypes from a global perspective. A comprehensive database of DENV sequences containing both serotype and genotype data and epidemiological data is crucial to trace DENV outbreak isolates and promptly respond to outbreaks.


id: cord-326840-piv6h7oq
author: Paemanee, Atchara
date: 2018-05-16
extension: .txt
mime: text/plain
words: 3010
sentence: 124
flesch: 47
cache: cache/cord-326840-piv6h7oq.txt
txt: txt/cord-326840-piv6h7oq.txt
title:
  Screening of melatonin, α-tocopherol, folic acid, acetyl-l-carnitine and resveratrol for anti-dengue 2 virus activity

summary:
  After 2 h of virus infection, medium was replaced with 2 concentrations of each compound in DMEM with 10% FBS and then incubated at 37 °C, 5% CO 2 . Overall, an estimated 3.9 billion people are at risk of dengue virus infection in almost 128 countries in tropical and subtropical regions [5] .


id: cord-319174-pbqjg7hf
author: Song, Ke-Yu
title: A novel reporter system for neutralizing and enhancing antibody assay against dengue virus
date: 2014-02-18
extension: .txt
mime: text/plain
words: 3529
sentence: 172
flesch: 48
cache: cache/cord-319174-pbqjg7hf.txt
txt: txt/cord-319174-pbqjg7hf.txt
summary:
  Identity of blood and tissue leukocytes supporting in vitro infection Infection-enhancing and -neutralizing activities of mouse monoclonal antibodies against dengue type 2 and 4 viruses are controlled by complement levels Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cells Flow cytometry-based assay for titrating dengue virus Enzyme-linked immunosorbent assay-format tissue culture infectious dose-50 test for titrating dengue virus Development of an antibody-dependent enhancement assay for dengue virus using stable BHK-21 cell lines expressing Fc gammaRIIA Role of dendritic cells in antibody-dependent enhancement of dengue virus infection Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • I. Infection enhancement by non-neutralizing antibody Dengue virus identification by the plaque reduction neutralization test Dengue vaccine development and dengue viral neutralization and enhancement assays Development and characterization of a stable luciferase dengue virus for high-throughput screening Dengue virus-specific and flavivirus group determinants identified with monoclonal antibodies by indirect immunofluorescence A broadly flavivirus cross-neutralizing monoclonal antibody that recognizes a novel epitope within the fusion loop of E protein Rapid detection of anti-Vaccinia virus neutralizing antibodies Comparison of plaque-and flow cytometry-based methods for measuring dengue virus neutralization Studies of neutralising antibodies to SV40 in human sera An infectious West Nile virus that expresses a GFP reporter gene Doms RW: A rapid and quantitative assay for measuring antibody-mediated neutralization of West Nile virus infection Comparative evaluation of three assays for measurement of dengue virus neutralizing antibodies Enzyme-linked immunosorbent assay-format microneutralization test for dengue viruses Comparison of plaque-and enzyme-linked immunospot-based assays to measure the neutralizing activities of monoclonal antibodies specific to domain III of dengue virus envelope protein Dengue reporter virus particles for measuring neutralizing antibodies against each of the four dengue serotypes Illumination of parainfluenza virus infection and transmission in living animals reveals a tissue-specific dichotomy Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses A novel HIV-1 reporter virus with a membrane-bound Gaussia princeps luciferase Reverse genetics of SARS-related coronavirus using vaccinia virus-based recombination Biomineralization-based virus shell-engineering: towards neutralization escape and tropism expansion Dengue virus capsid protein usurps lipid droplets for viral particle formation A simple assay system for infectionenhancing and -neutralizing antibodies to dengue type 2 virus using layers of semi-adherent K562 cells Human skin Langerhans cells are targets of dengue virus infection A real-time PCR procedure for detection of dengue virus serotypes 1, 2, and 3, and their quantitation in clinical and laboratory samples Dengue viruses and mononuclear phagocytes.


id: cord-303818-z3js3mr4
author: Chen, Huixin
date: 2015-10-11
extension: .txt
mime: text/plain
words: 3849
sentence: 135
flesch: 43
cache: cache/cord-303818-z3js3mr4.txt
txt: txt/cord-303818-z3js3mr4.txt
title:
  Development and Evaluation of a SYBR Green–Based Real-Time Multiplex RT-PCR Assay for Simultaneous Detection and Serotyping of Dengue and Chikungunya Viruses

summary:
  I. Infection enhancement by non-neutralizing antibody Enhancement of dengue virus infection in monocytes by flavivirus antisera Dengue typing assay based on real-time PCR using SYBR Green I Standardization of immunoglobulin M capture enzymelinked immunosorbent assays for routine diagnosis of arboviral infections Development of group-and serotype-specific one-step SYBR green I-based real-time reverse transcription-PCR assay for dengue virus Development of real-time reverse transcriptase PCR assays to detect and serotype dengue viruses The pair of DEst1 and CHK1 (Figure 2 ) (the specific Tm of CHIKV PCR amplicon was 88.28 C, with coefficient of variation of 0.46%) was selected because not only was it able to detect DENV and CHIKV but also it had a similar annealing temperature and low tendency of forming heterodimers.


id: cord-317169-qlqavi4t
author: Chiow, K.H.
date: 2015-12-19
extension: .txt
mime: text/plain
words: 4317
sentence: 167
flesch: 44
cache: cache/cord-317169-qlqavi4t.txt
txt: txt/cord-317169-qlqavi4t.txt
title:
  Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection

summary:
  Challenge to molecular biology Molecular evolution of dengue type 2 virus in Thailand Dengue viremia titer, antibody response pattern, and virus serotype correlate with severity Virucidal effects of the steam distillate from Houttuynia cordata and its components on HSV-1, influenza virus, and HIV The constituents and their bioactivities of Houttuynia cordata Houttuynia cordata blocks HSV infection through inhibition of NF-kB activation A current update on the phytopharmacological aspects of Houttuynia cordata Thunb Houttuynia cordata targets the beginning stage of herpes simplex virus infection Houttuynia cordata extracts and constituents inhibit the infectivity of dengue virus type 2 in vitro Establishment of HPLC-DAD-MS fingerprint of fresh Houttuynia cordata Flavonoids, a class of natural products of high pharmacological potency Antiviral effect of flavonoids on the dengue virus Antiviral effect of catechins in green tea on influenza virus A seroprevalence survey of dengue virus infection in healthy Singapore university undergraduates by enzyme immunoassay and plaque reduction neutralization test Differential dengue cross-reactive and neutralizing antibody responses in BALB/c and Swiss albino mice induced by immunization with flaviviral vaccines and by infection with homotypic dengue-2 virus strains Mapping of a region of dengue virus type-2 glycoprotein required for binding by a neutralizing monoclonal antibody Structural basis for antiviral activity of flavonoidsnaturally occurring compounds High-performance liquid chromatographic determination of selected flavonols in Ginkgo biloba solid oral dosage forms Antiviral effect of flavonoids on human viruses Antiviral activity of flavones and potentiation by ascorbate Present status and prospects of flavonoids as anti-viral agents Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5) Inhibitory effects of quercetin 3-rhamnoside on influenza A virus replication Flavonoids as noncompetitive inhibitors of dengue virus NS2B-NS3 protease: inhibition kinetics and docking studies Combined antiviral effects of flavonoids and 5-ethyl-2 0 -deoxyuridine on the multiplication of herpesviruses Inhibition of fowlpox virus by an aqueous acetone extract from galls of Guiera senegalensis J. F. Gmel (Combretaceae) Design and synthesis of cinanserin analogs as severe acute respiratory syndrome coronavirus 3CL protease inhibitors Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris Atlas of coronavirus replicase structure Chemical composition and hepatoprotective effects of polyphenol-rich extract from Houttuynia cordata tea Immunomodulatory and anti-SARS activities of Houttuynia cordata In vitro and in vivo effects of Houttuynia cordata on infectious bronchitis virus The inhibitory actions of Houttuynia cordata aqueous extract on dengue virus and dengueinfected cell Development of animal models against emerging coronaviruses: from SARS to MERS coronavirus Houttuynia cordata Thunb: a review of phytochemistry and pharmacology and quality control We thank Annie Hsu and S.H. Lau for laboratory assistance, T. Narasaraju for helpful advice, and Mary Ng for providing the dengue virus strain. (Saururaceae) and three of its constituent flavonoids (quercetin, quercitrin and rutin) against murine coronavirus and dengue virus (DENV).


id: cord-353241-ityhcak7
author: Zhu, Hanliang
title: IoT PCR for pandemic disease detection and its spread monitoring
date: 2020-01-15
extension: .txt
mime: text/plain
words: 4302
sentence: 153
flesch: 46
cache: cache/cord-353241-ityhcak7.txt
txt: txt/cord-353241-ityhcak7.txt
summary:
  Data transfer between the BT unit and PCR system is conducted bi-directionally via a universal asynchronous receiver-transmitter interface. His research interests include microfluidics and miniaturization and application of PCR systems


id: cord-355489-tkvfneje
author: Mendez, Jairo A
title: Phylogenetic history demonstrates two different lineages of dengue type 1 virus in Colombia
date: 2010-09-14
extension: .txt
mime: text/plain
words: 4616
sentence: 194
flesch: 43
cache: cache/cord-355489-tkvfneje.txt
txt: txt/cord-355489-tkvfneje.txt
summary:
  Clinical Investigations Genetic variation and microevolution of dengue 2 virus in Southeast Asia Molecular evolution and distribution of dengue viruses type 1 and 2 in nature Phylogenetic relationships of dengue-2 viruses Molecular epidemiology of dengue-1 and dengue-4 viruses Molecular evolution and phylogeny of dengue-4 viruses Molecular evolution of dengue type 2 virus in Thailand Molecular epidemiology of dengue viruses in Brazil Molecular epidemiology of dengue type 2 virus in Venezuela: evidence for in situ virus evolution and recombination Phylogenetic relationships and differential selection pressures among genotypes of dengue-2 virus Molecular evolution and phylogeny of dengue type 4 virus in the Caribbean The origin, emergence and evolutionary genetics of dengue virus Molecular epidemiological study of dengue virus type 1 in Taiwan Genotipificación y análisis filogenético de cepas colombianas del virus dengue tipo 2 Molecular epidemiology of dengue virus type 3 in Venezuela Phylogeography and molecular evolution of dengue 2 in the Caribbean basin Introduction of the American/Asian genotype of dengue 2 virus into the Yucatan State of Mexico Dengue virus 3 genotype 1 assosiated with dengue fever and dengue hemorrhagic fever Use of a Short Fragment of the C-Terminal E Gene for Detection and Characterization of Two New Lineages of Dengue Virus 1 in India Simultaneous circulation of genotypes I and III of dengue virus 3 in Colombia Phylogenetic studies reveal existence of multiple lineages of a single genotype of DENV-1 (genotype III) in India during 1956-2007 Dengue virus structural differences that correlate with pathogenesis Effect of age on outcome of secondary dengue 2 infections Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study Race: a risk factor for dengue hemorrhagic fever Dengue virus evolution and virulence models Microevolution and virulence of dengue viruses Lineage extinction and replacement in dengue type 1 virus populations are due to stochastic events rather than to natural selection Invasion and maintenance of dengue virus type 2 and type 4 in the Americas Molecular epidemiology of dengue 2 viruses in the Philippines: genotype shift and local evolution Molecular evolution of dengue 2 virus in Puerto Rico: Positive selection in the viral envelope accompanies clade reintroduction CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions specific gap penalties and weight matrix choice MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0 BEAST: Bayesian evolutionary analysis by sampling trees Estimating the rate of molecular evolution: incorporating non-contemporaneous sequences into maximum likelihood phylogenies Bayesian inference of phylogeny: a non-technical primer Relaxed phylogenetics and dating with confidence RNA virus mutations and fitness for survival The causes and consequences of genetic variation in dengue virus Phylogenetic evidence for adaptive evolution of dengue viruses in nature Selection-driven evolution of emergent dengue virus Patterns of intra-and interhost nonsynonymous variation reveal strong purifying selection in dengue virus


id: cord-330743-o11d0aa1
author: Yu, Xi
date: 2020-05-25
extension: .txt
mime: text/plain
words: 4488
sentence: 178
flesch: 47
cache: cache/cord-330743-o11d0aa1.txt
txt: txt/cord-330743-o11d0aa1.txt
title:
  Broad-spectrum virucidal activity of bacterial secreted lipases against flaviviruses, SARS-CoV-2 and other enveloped viruses

summary:
  Incubation of the culture supernatant but not the bacterial lysates resulted in significant suppression of DENV ( Figure 1B ) and ZIKV ( Figure 1C ) infectivity in Vero cells, indicating that an extracellular effector(s) secreted by Csp_BJ was responsible for viral inhibition. Either the upper retentate (proteins and large peptides) or the lower liquid filtrate (small molecule compounds and short peptides) was mixed with the viruses for incubation in Vero cells ( Figure 1D ).


id: cord-355179-wmfwl2bh
author: Jung, Eunhye
date: 2019-06-18
extension: .txt
mime: text/plain
words: 5317
sentence: 181
flesch: 34
cache: cache/cord-355179-wmfwl2bh.txt
txt: txt/cord-355179-wmfwl2bh.txt
title:
  Neutralization of Acidic Intracellular Vesicles by Niclosamide Inhibits Multiple Steps of the Dengue Virus Life Cycle In Vitro

summary:
  To rule out the possibility that virus infected cells were more sensitive to niclosamide treatment resulting in synergistic cytotoxicity compared to mock-infected cells, the percentages of live and dead cells from mock-and DENV-2 infected cultures with increasing concentrations of niclosamide were determined by FACS analysis. Dengue/dengue haemorrhagic fever: history and current status The global distribution and burden of dengue Dengue: a continuing global threat Fields Virology Zika Virus Associated with Microcephaly Zika Virus and Birth Defects-Reviewing the Evidence for Causality Rapid Spread of Zika Virus in The Americas-Implications for Public Health Preparedness for Mass Gatherings at the 2016 Brazil Olympic Games Guillain-Barre Syndrome outbreak associated with Zika virus infection in French Polynesia: a casecontrol study Guillain-Barre syndrome associated with the Zika virus outbreak in Brazil Magnetic resonance imaging findings in Guillain-Barre syndrome caused by Zika virus infection The dengue viruses NS3 protease from flavivirus as a target for designing antiviral inhibitors against dengue virus Flavivirus infection enhancement in macrophages: radioactive and biological studies on the effect of antibody on viral fate Morphogenesis of yellow fever virus 17D in infected cell cultures Dissecting the cell entry pathway of dengue virus by single-particle tracking in living cells Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking The entry machinery of flaviviruses Receptors and routes of dengue virus entry into the host cells Molecular basis of endosomal-membrane association for the dengue virus envelope protein The flavivirus precursor membrane-envelope protein complex: structure and maturation New insights into the immunopathology and control of dengue virus infection Structure of the immature dengue virus at low pH primes proteolytic maturation Rodenhuis-Zybert, I. & Wilschut, J. Flavivirus cell entry and membrane fusion Acidotropic amines inhibit proteolytic processing of flavivirus prM protein Fusion activity of flaviviruses: comparison of mature and immature (prM-containing) tick-borne encephalitis virions Structural changes and functional control of the tick-borne encephalitis virus glycoprotein E by the heterodimeric association with protein prM Cleavage of protein prM is necessary for infection of BHK-21 cells by tickborne encephalitis virus Functional importance of dengue virus maturation: infectious properties of immature virions pH-Dependent entry of chikungunya virus fusion into mosquito cells Proteolytic activation of tick-borne encephalitis virus by furin Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity Worm cure without tears.


id: cord-011026-iapgkz0p
author: El-Bitar, Alaa M. H.
date: 2019-07-06
extension: .txt
mime: text/plain
words: 5255
sentence: 204
flesch: 45
cache: cache/cord-011026-iapgkz0p.txt
txt: txt/cord-011026-iapgkz0p.txt
title:
  Smp76, a Scorpine-Like Peptide Isolated from the Venom of the Scorpion Scorpio maurus palmatus, with a Potent Antiviral Activity Against Hepatitis C Virus and Dengue Virus

summary:
  Smp76 antiviral activity was evaluated using a cell culture technique utilizing Huh7it-1, Vero/SLAM, HCV (JFH1, genotype 2a) and DENV (Trinidad 1751, type 2). The present data clearly showed that smp76 inhibits the ability of HCV virus to infect the host cells.


id: cord-011968-abd891ej
author: Lai, Yen-Chung
date: 2020-06-12
extension: .txt
mime: text/plain
words: 5735
sentence: 207
flesch: 32
cache: cache/cord-011968-abd891ej.txt
txt: txt/cord-011968-abd891ej.txt
title:
  Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target

summary:
  However, infection of macrophages with Sindbis virus resulted in MIF release from intracellular pools without a significant increase in MIF transcription or cell death [48] . In this paper, the pathogenic roles of MIF and the regulation of MIF secretion during DENV infection are reviewed.


id: cord-328661-spxgox52
author: Yu, Jianhai
date: 2019-08-05
extension: .txt
mime: text/plain
words: 5838
sentence: 220
flesch: 42
cache: cache/cord-328661-spxgox52.txt
txt: txt/cord-328661-spxgox52.txt
title:
  Epidemiological and Evolutionary Analysis of Dengue-1 Virus Detected in Guangdong during 2014: Recycling of Old and Formation of New Lineages

summary:
  The driving force for 2014 dengue outbreak in Guangdong Multiple sources of infection and potential endemic characteristics of the large outbreak of dengue in Guangdong in 2014 Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou Phylogenetic history demonstrates two different lineages of dengue type 1 virus in Colombia Population dynamics of DENV-1 genotype V in Brazil is characterized by co-circulation and strain/lineage replacement Phylodynamics of DENV-1 reveals the spatiotemporal co-circulation of two distinct lineages in 2013 and multiple introductions of dengue virus in Goiás, Brazil Dengue virus surveillance in Singapore reveals high viral diversity through multiple introductions and in situ, evolution Dengue in Singapore from 2004 to 2016: cyclical epidemic patterns dominated by serotypes 1 and 2 Molecular characterization of the E gene of dengue virus type 1 isolated in Guangdong province The origin of dengue viruses caused the DF outbreak in Guangdong province, China Spatial and temporal distribution characteristics of dengue fever in Guangdong province, China during Current infection status and epidemic risk analysis of dengue fever and chikungunya in Guangdong province Distribution of dengue virus serum type I in Guangdong The epidemiological characteristics and molecular phylogeny of the dengue virus in Guangdong, China Evolutionary and phylodynamic analyses of, dengue virus, serotype I in Guangdong province, China, between Molecular surveillance of dengue in semarang, Indonesia revealed the circulation of an old genotype of dengue virus serotype-1 Continuous dengue type 1 virus genotype shifts followed by co-circulation, clade shifts and subsequent disappearance in Surabaya Molecular epidemiology of dengue viruses in three provinces of Lao PDR Dengue viruses in Papua New Guinea: evidence of endemicity and phylogenetic variation, including the evolution of new genetic lineages Temporal distribution of dengue virus serotypes in Colombian endemic area and dengue incidence. The role of models in reconstructing evolutionary trees Molecular evolution and phylogeny of dengue-4 viruses Phylogeny and molecular evolution of the hepatitis C virus Molecular phylogeny and evolutionary dynamics of influenza A nonstructural (NS) gene Non Fc receptor-mediated infection of human macrophages by dengue virus serotype 2 Identification of a major determinant of mouse neurovirulence of dengue virus type 2 using stably cloned genomiclength cDNA Molecular genotyping of dengue viruses by phylogenetic analysis of the sequences of individual genes Dengue fever in mainland China Spatial analysis of dengue fever in Guangdong province Epidemic situation of dengue fever in Guangdong province Molecular epidemiology of dengue viruses in southern China from 1978 to The prevalence and endemic nature of dengue infections in Guangdong, south China: an epidemiological, serological, and etiological study from Characterizing a large outbreak of dengue fever in Guangdong province Epidemiology and characteristics of the dengue outbreak in Guangdong, southern China, in 2014 DNASTAR's Lasergene sequence analysis software Basic local alignment search tool (BLAST)


id: cord-342157-qjyooq68
author: King, Chwan-Chuen
title: Comparative analysis of full genomic sequences among different genotypes of dengue virus type 3
date: 2008-05-21
extension: .txt
mime: text/plain
words: 5869
sentence: 215
flesch: 42
cache: cache/cord-342157-qjyooq68.txt
txt: txt/cord-342157-qjyooq68.txt
summary:
  Sequence diversity and selection pressure of different genomic regions among DENV-3 different genotypes was further examined to understand the global DENV-3 evolution. With different DENV-3 genotypes imported into Taiwan from Southeast Asia and other parts of the world, this virus collection provides an excellent opportunity to examine the sequence diversity of different genes of the full-length DENV-3 viral RNA genome for genotypes other than genotype IV.


id: cord-345898-a6vt8kso
author: Ren, Linzhu
title: Live Cell Reporter Systems for Positive-Sense Single Strand RNA Viruses
date: 2016-01-04
extension: .txt
mime: text/plain
words: 6005
sentence: 225
flesch: 32
cache: cache/cord-345898-a6vt8kso.txt
txt: txt/cord-345898-a6vt8kso.txt
summary:
  Moreover, the replicon-defective reporter gene assay could detect a variety of Alphaviruses from tissue cultures with a limit of detection between one and ten (plaque-forming unit) PFU for SINV while other RNA viruses, such as the Japanese encephalitis virus and Tahyna virus, displayed negative results with this system [44] . Cell-based reporter systems have enhanced our understanding of the molecular mechanisms of virus replication and pathogenesis as well as virus interactions with host cells. N pro of CSFV was not only involved with virus RNA translation in the cytoplasm [27] but also counteracted double-stranded RNAmediated apoptosis and IFN-α/β induction


id: cord-025181-eg108wcd
author: Zheng, Zhihang
date: 2020-05-25
extension: .txt
mime: text/plain
words: 5990
sentence: 227
flesch: 50
cache: cache/cord-025181-eg108wcd.txt
txt: txt/cord-025181-eg108wcd.txt
title:
  Establishment of Murine Infection Models with Biological Clones of Dengue Viruses Derived from a Single Clinical Viral Isolate

summary:
  Our research here provides two kinds of dengue virus infection mouse models, which reproduce both severe and self-limited manifestations of human diseases, expanding the current choice of dengue viral infection small animal models. As type I/II interferon deficient mice are more susceptible to dengue virus infection, we determined the in vivo infectivity of these two viruses in type I and type II IFN receptors double knock-out AG6 mice.


id: cord-002413-795wuqz5
author: Balinsky, Corey A.
date: 2017-02-14
extension: .txt
mime: text/plain
words: 5495
sentence: 173
flesch: 35
cache: cache/cord-002413-795wuqz5.txt
txt: txt/cord-002413-795wuqz5.txt
title:
  IRAV (FLJ11286), an Interferon-Stimulated Gene with Antiviral Activity against Dengue Virus, Interacts with MOV10

summary:
  A Mascot (Matrix Science, Beachwood, OH) search of the data was performed against a concatenated sequence file containing dengue virus proteins found in the UniProtKB TrEMBL database, human protein UniProtKB Swiss-Prot, and the common contaminant proteins found in the GPM.org's cRAP database, all downloaded in March 2014. MOV10 provides antiviral activity against RNA viruses by enhancing RIG-I-MAVS-independent IFN induction Host protein Moloney leukemia virus 10 (MOV10) acts as a restriction factor of influenza A virus by inhibiting the nuclear import of the viral nucleoprotein Up-frameshift protein 1 (UPF1): multitalented entertainer in RNA decay The host nonsense-mediated mRNA decay pathway restricts mammalian RNA virus replication UPF1 is crucial for the infectivity of human immunodeficiency virus type 1 progeny virions Dysregulation of TTP and HuR plays an important role in cancers Changes in cellular mRNA stability, splicing, and polyadenylation through HuR protein sequestration by a cytoplasmic RNA virus HuR displaces polypyrimidine tract binding protein to facilitate La binding to the 3= untranslated region and enhances hepatitis C virus replication Hepatitis B virus X upregulates HuR protein level to stabilize HER2 expression in hepatocellular carcinoma cells HuR and Ago2 bind the internal ribosome entry site of enterovirus 71 and promote virus translation and replication Vaccine candidates derived from a novel infectious cDNA clone of an American genotype dengue virus type 2 Epidemiologic, clinical, and virologic observations on dengue in the Kingdom of Tonga Modulation of Dengue virus infection in human cells by alpha, beta, and gamma interferons Nucleolin interacts with the dengue virus capsid protein and plays a role in formation of infectious virus particles


id: cord-306204-rkher4ly
author: Pong, Lian Yih
title: Anti-dengue virus serotype 2 activity of tannins from porcupine dates
date: 2020-05-20
extension: .txt
mime: text/plain
words: 6073
sentence: 254
flesch: 49
cache: cache/cord-306204-rkher4ly.txt
txt: txt/cord-306204-rkher4ly.txt
summary:
  The antiviral activity of sulfated polysaccharides against dengue virus is dependent on virus serotype and host cell Study by infrared spectroscopy and thermogravimetric analysis of tannins and tannic acid Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate Analysis of the steps involved in dengue virus entry into host cells Heparin inhibits dengue-2 virus infection of five human liver cell lines Antiviral activity of lanatoside C against dengue virus infection Evaluation of antiviral activities of Houttuynia cordata Thunb. It is caused by dengue virus (DENV) which is circulated as four distinct serotypes that are antigenic closely related, DENV-1, -2, -3 and -4.


id: cord-276718-3lujp0oy
author: Neeraja, M.
date: 2014-10-24
extension: .txt
mime: text/plain
words: 6153
sentence: 206
flesch: 45
cache: cache/cord-276718-3lujp0oy.txt
txt: txt/cord-276718-3lujp0oy.txt
title:
  Rapid detection and differentiation of dengue virus serotypes by NS1 specific reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay in patients presenting to a tertiary care hospital in Hyderabad, India

summary:
  b RT-LAMP and CDC real time RT-PCR assay detected 8 samples which were negative for NS1 Ag by ELISA and NS1 RT PCR assay. All the primers were assessed for specificity before use in LAMP assays with a BLAST search with sequences in the Gen Bank (Table 1) .


id: cord-355610-7xy4s483
author: Hu, Dan
date: 2019-06-26
extension: .txt
mime: text/plain
words: 6192
sentence: 250
flesch: 48
cache: cache/cord-355610-7xy4s483.txt
txt: txt/cord-355610-7xy4s483.txt
title:
  A broadly neutralizing germline-like human monoclonal antibody against dengue virus envelope domain III

summary:
  Homology modeling of variable regions of heavy (V H ) and light (V L ) chains for m366.6 scFv antibody was carried out using the SWISS-MODEL workspace How to increase the neutralization breadth is a key issue in developing anti-DENV antibodies.


id: cord-295191-xu26mvc3
author: Avirutnan, Panisadee
title: Complement and its role in protection and pathogenesis of flavivirus infections
date: 2008-12-30
extension: .txt
mime: text/plain
words: 6127
sentence: 219
flesch: 23
cache: cache/cord-295191-xu26mvc3.txt
txt: txt/cord-295191-xu26mvc3.txt
summary:
  lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex Identification of a 145,000 Mr membrane protein as the C3d receptor (CR2) of human B lymphocytes Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19 C3d of complement as a molecular adjuvant: bridging innate and acquired immunity Enhancement of antibodies to the human immunodeficiency virus type 1 envelope by using the molecular adjuvant C3d C3d enhancement of antibodies to hemagglutinin accelerates protection against influenza virus challenge Fusion to C3d enhances the immunogenicity of the E2 glycoprotein of type 2 bovine viral diarrhea virus Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen Antibody response to a T-dependent antigen requires B cell expression of complement receptors Regulation of the B cell response to T-dependent antigens by classical pathway complement Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2 B lymphocyte memory: role of stromal cell complement and FcgammaRIIB receptors Dependence of germinal center B cells on expression of CD21/CD35 for survival Impaired affinity maturation in Cr2−/− mice is rescued by adjuvants without improvement in germinal center development Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte Complement receptor 1/CD35 is a receptor for mannan-binding lectin Complement receptor type 1 (CR1 CD35) is a receptor for C1q Expression of C3b receptors on human be cells and myelomonocytic cells but not natural killer cells Both Kupffer cells and liver endothelial cells play an important role in the clearance of IgA and IgG immune complexes Clearance of antidouble-stranded DNA antibodies: the natural immune complex clearance mechanism Their use in a distribution study showing that mouse erythrocytes and platelets are CR1-negative The murine complement receptor gene family. Evidence for a single gene model of mouse complement receptors 1 and 2 Humoral immune responses in Cr2−/− mice: enhanced affinity maturation but impaired antibody persistence Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection Complement component 3 is required for optimal expansion of CD8 T cells during a systemic viral infection Expression of complement receptors 1 and 2 on follicular dendritic cells is necessary for the generation of a strong antigen-specific IgG response Evidence for an important interaction between a complement-derived CD21 ligand on follicular dendritic cells and CD21 on B cells in the initiation of IgG responses Local synthesis of complement component C3 regulates acute renal transplant rejection Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses C3b covalently associated to tetanus toxin modulates TT processing and presentation by U937 cells Covalent binding of C3b to tetanus toxin: influence on uptake/internalization of antigen by antigen-specific and non-specific B cells Antigen-bound C3b and C4b enhance antigenpresenting cell function in activation of human T-cell clones Modulation of antigen processing and presentation by covalently linked complement C3b fragment B cell receptors and complement receptors target the antigen to distinct intracellular compartments Complement C3b fragment covalently linked to tetanus toxin increases lysosomal sodium dodecyl sulfate-stable HLA-DR dimer production C3b complexation diversifies naturally processed T cell epitopes Maturation of dendritic cells abrogates C1q production in vivo and in vitro Complement protein C1q induces maturation of human dendritic cells Immune modulation of human dendritic cells by complement T cell-dependent immune response in C1q-deficient mice: defective interferon gamma production by antigen-specific T cells Immune complex processing in C1q-deficient mice A novel role of complement factor C1q in augmenting the presentation of antigen captured in immune complexes to CD8+ T lymphocytes Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens Antigen-antibody immune complexes empower dendritic cells to efficiently prime specific CD8+ CTL responses in vivo Immune complex-loaded dendritic cells are superior to soluble immune complexes as antitumor vaccine Protective immune responses against West Nile virus are primed by distinct complement activation pathways Complement contributes to protective immunity against reinfection by Plasmodium chabaudi chabaudi parasites HIV and human complement: inefficient virolysis and effective adherence Viral mimicry of the complement system Role of complement in immune regulation and its exploitation by virus Virus complement evasion strategies Complement evasion by human pathogens Cutting edge: productive HIV-1 infection of dendritic cells via complement receptor type 3 (CR3, CD11b/CD18)


id: cord-273065-peqz7okh
author: Girard, Marc
title: Arboviruses: A global public health threat
date: 2020-04-24
extension: .txt
mime: text/plain
words: 5575
sentence: 212
flesch: 45
cache: cache/cord-273065-peqz7okh.txt
txt: txt/cord-273065-peqz7okh.txt
summary:
  Nevertheless, the substantial public health benefits of even a moderately effective dengue vaccine continue to drive all the efforts at developing dengue vaccines [29, 30] , hoping that safety concerns may be adequately addressed. Dr Joao Bosco Siqueira reported that Brazil had suffered from a shortage of yellow fever vaccine.


id: cord-282742-eyukbot7
author: Diosa-Toro, Mayra
title: Arthropod-Borne Flaviviruses and RNA Interference: Seeking New Approaches for Antiviral Therapy
date: 2013-02-20
extension: .txt
mime: text/plain
words: 6502
sentence: 226
flesch: 37
cache: cache/cord-282742-eyukbot7.txt
txt: txt/cord-282742-eyukbot7.txt
summary:
  Stepwise processing and subcellular localization MicroRNA genes are transcribed by RNA polymerase II Utilizing liver-specific microRNA-122 to modulate replication of dengue virus replicon Flaviviridae: The viruses and their replication Inhibition of Japanese encephalitis virus NS1 protein expression in cell by small interfering RNAs Nuclear export of microRNA precursors Markers for trans-Golgi membranes and the intermediate compartment localize to induced membranes with distinct replication functions in flavivirus-infected cells Detection of small RNAs containing the 5'-and the 3'-end sequences of viral genome during West Nile virus replication 5'-and 3'-noncoding regions in flavivirus RNA The utility of siRNA transcripts produced by RNA polymerase i in down regulating viral gene expression and replication of negative-and positive-strand RNA viruses Overview: Japanese encephalitis RNA interference modulates replication of dengue virus in Drosophila melanogaster cells Developing arbovirus resistance in mosquitoes Expression of vector-based small interfering RNA against West Nile virus effectively inhibits virus replication Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression RNA interference inhibits yellow fever virus replication in vitro and in vivo RNA interference mediated silencing of Hsp60 gene in human monocytic myeloma cell line U937 revealed decreased dengue virus multiplication Six RNA viruses and forty-one hosts: Viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems Structural proteomics of dengue virus Impact of microRNAs for pathogenesis and treatment of hepatitis C virus infection Identification of microRNAs of the herpesvirus family Effective inhibition of Japanese encephalitis virus replication by small interfering RNAs targeting the NS5 gene siRNA and innate immunity Functional microRNA generated from a cytoplasmic RNA virus Dengue virus type 2 infections of Aedes aegypti are modulated by the mosquito's RNA interference pathway Evidence that RNA silencing functions as an antiviral defense mechanism in fungi Inhibition of genes expression of SARS coronavirus by synthetic small interfering RNAs Efficient and targeted delivery of siRNA in vivo Endogenous antiviral mechanisms of RNA interference: A comparative biology perspective Viruses, microRNAs, and host interactions Identification of microRNAs expressed in two mosquito vectors, Aedes albopictus and Culex quinquefasciatus Flavivirus cell entry and membrane fusion Induction of the cellular microRNA, Hs_154, by West Nile virus contributes to virusmediated apoptosis through repression of antiapoptotic factors Cellular microRNAs inhibit replication of the H1N1 influenza A virus in infected cells Inhibition of dengue virus infections in cell cultures and in AG129 mice by a small interfering RNA targeting a highly conserved sequence Molecular mechanisms of flavivirus membrane fusion Targeted delivery of small interfering RNA to human dendritic cells to suppress dengue virus infection and associated proinflammatory cytokine production RNA interference targeted to the conserved dimerization initiation site (DIS) of HIV-1 restricts virus escape mutation Suppression of hepatitis C virus replicon by RNA interference directed against the NS3 and NS5B regions of the viral genome How innate immune mechanisms contribute to antibodyenhanced viral infections West Nile virus: The complex biology of an emerging pathogen Recent developments in understanding dengue virus replication Ecology and geographical expansion of Japanese encephalitis virus Genome cyclization as strategy for flavivirus RNA replication RNA silencing as a plant immune system against viruses Water-related diseases. The genus Flavivirus of the family Flaviviridae comprises more than 70 enveloped RNA viruses and depending on the virus can cause disease and mortality in humans and animals.


id: cord-355906-yeaw9nr8
author: Nedjadi, Taoufik
title: Tackling dengue fever: Current status and challenges
date: 2015-12-09
extension: .txt
mime: text/plain
words: 6825
sentence: 270
flesch: 40
cache: cache/cord-355906-yeaw9nr8.txt
txt: txt/cord-355906-yeaw9nr8.txt
summary:
  Development, characterization and application of monoclonal antibodies against Brazilian dengue virus isolates A simple one-step real-time RT-PCR for diagnosis of dengue virus infection Current advances in dengue diagnosis Reliable classifier to differentiate primary and secondary acute dengue infection based on IgG ELISA Human genetic susceptibility to intracellular pathogens Host genetic susceptibility to severe dengue infection Impact of dengue virus infection on feeding behavior of Aedes aegypti Dengue virus infection of the Aedes aegypti salivary gland and chemosensory apparatus induces genes that modulate infection and blood-feeding behavior A novel amino acid substitution in a voltage gated sodium channel is associated with knockdown resistance to permethrin in Aedes aegypti Widespread distribution of newly found point mutation in voltage-gated sodium channel in pyrethroid-resistant Aedes aegypti populations in Vietnam Detection of the V1016G mutation in the voltage-gated sodium channel gene of Aedes aegypti (Diptera: Culicidae) by allele-specific PCR assay, and its distribution and effect on deltamethrin resistance in Thailand Race: A risk factor for dengue hemorrhagic fever Asymptomatic dengue infection in a Cuban population confirms the protective role of the RR variant of the FcgammaRIIa polymorphism A variant in the CD209 promoter is associated with severity of the disease Dengue and dengue haemorrhagic fever: Implications of host genetics Polymorphisms of the TAP 1 and 2 gene may influence clinical outcome of primary dengue viral infection All serotypes of dengue virus induce HLA-A2 major histocompatibility complex class I promoter activity in human liver cells Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection Cell type specificity and host genetic polymorphisms influence antibodydependent enhancement of dengue virus infection The 1a, 25-dihydroxy-vitamin D3 reduces dengue virus infection in human myelomonocyte (U937) and hepatic (Huh-7) cell lines and cytokine production in the infected monocytes Association of vitamin D receptor gene polymorphisms with clinical outcomes of dengue virus infection Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1 Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity Genetic variants of MICB and PLCE1 and associations with non-severe dengue Host gene expression profiling of dengue virus infection in cell lines and patients Common variants of chemokine receptor gene CXCR3 and its ligands CXCL10 and CXCL11 associated with vascular permeability of dengue infection in peninsular Malaysia Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome Two other compounds have also been shown to qualify as potent inhibitors of dengue virus infection are imino-sugars deoxynojirimycin and castanospermine


id: cord-276364-zyw5aukk
author: Wong, Ho Him
title: Manipulation of autophagy by (+) RNA viruses
date: 2019-08-08
extension: .txt
mime: text/plain
words: 6910
sentence: 278
flesch: 27
cache: cache/cord-276364-zyw5aukk.txt
txt: txt/cord-276364-zyw5aukk.txt
summary:
  Cytochemical localization of lysosomal enzymes in infected cells Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virus HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein Autophagy protects against Sindbis virus infection of the central nervous system PLA2G16 represents a switch between entry and clearance of Picornaviridae CALCOCO2/NDP52 and SQSTM1/p62 differentially regulate coxsackievirus B3 propagation Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A Inflammation-induced, STING-dependent autophagy restricts Zika virus infection in the drosophila brain Amino acid substitutions in the non-structural proteins 4A or 4B modulate the induction of autophagy in West Nile virus infected cells independently of the activation of the unfolded protein response The role of secretory autophagy in Zika virus transfer through the placental barrier Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3-I-and EDEM1-containing membranes Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy Hepatitis C virus upregulates Beclin1 for induction of autophagy and activates mTOR signaling The autophagy elongation complex (ATG5-12/16L1) positively regulates HCV replication and is required for wild-type membranous web formation Coronavirus membraneassociated papain-like proteases induce autophagy through interacting with Beclin1 to negatively regulate antiviral innate immunity Coronaviruses hijack the LC3-I-positive EDEMosomes, ER-derived vesicles exporting short-lived ERAD regulators, for replication Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate Cleavage of sequestosome 1/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling Protein 2B of coxsackievirus B3 induces autophagy relying on its transmembrane hydrophobic sequences Enteroviruses remodel autophagic trafficking through regulation of host SNARE proteins to promote virus replication and cell exit Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1 Viroporin activity of the foot-and-mouth disease virus non-structural 2B protein Modification of cellular autophagy protein LC3 by poliovirus Double-membraned liposomes sculpted by poliovirus 3AB protein This work was supported by Health and Medical Research Funds (16150592 and 17161202 and 17161032), and partially by Research Grants Council-General research funds (17112617). A similar finding was reported more recently with rotavirus where virus replication benefited from induction of autophagy while blocking degradation [34] .


id: cord-285538-3ah05ijf
author: Halstead, Scott B.
title: Chapter 19 Pathogenic Exploitation of Fc Activity
date: 2014-12-31
extension: .txt
mime: text/plain
words: 7649
sentence: 310
flesch: 32
cache: cache/cord-285538-3ah05ijf.txt
txt: txt/cord-285538-3ah05ijf.txt
summary:
  Crossreacting antibodies enhance dengue virus infection in humans Dengue virus (DENV) antibody-dependent enhancement of infection upregulates the production of anti-inflammatory cytokines, but suppresses anti-DENV free radical and pro-inflammatory cytokine production, in THP-1 cells Mechanisms of immune evasion induced by a complex of dengue virus and preexisting enhancing antibodies Differences in global gene expression in peripheral blood mononuclear cells indicate a significant role of the innate responses in progression of dengue fever but not dengue hemorrhagic fever Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients Patterns of host genomewide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles Interferon-dependent immunity is essential for resistance to primary dengue virus infection in mice, whereas T-and B-cell-dependent immunity are less critical Critical roles for both STAT1-dependent and STAT1-independent pathways in the control of primary dengue virus infection in mice Innate immune responses to dengue virus Shift from a Th1-type response to Th1-type in dengue haemorrhagic fever Cell type specificity and host genetic polymorphisms influence antibody dependent enhancement of dengue virus infection Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytes Ligation of Fc gamma receptor IIB inhibits antibody-dependent enhancement of dengue virus infection Infant dengue hemorrhagic fever: research opportunities ignored Analysis of repeat hospital admissions for dengue to estimate the frequency of third or fourth dengue infections resulting in admissions and dengue hemorrhagic fever, and serotype sequences Enhancement of dengue virus infection in monocytes by flavivirus antisera Absence of dengue 2 infection enhancement in human sera containing Japanese encephalitis antibodies Preexisting Japanese encephalitis virus neutralizing antibodies and increased symptomatic dengue illness in a schoolbased cohort in Thailand Protection against Japanese encephalitis by inactivated vaccines Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand. Identity of blood and tissue leukocytes supporting in vitro infection Immune enhancement of viral infection Flavivirus infection enhancement in macrophages: radioactive and biological studies on the effect of antibody on virus fate Flavivirus infection enhancement in macrophages: an electron microscopic study of viral cellular entry Evaluation of antibody-dependent enhancement of feline infectious peritonitis virus infectivity using in situ hybridization Complement-mediated, antibodydependent enhancement of HIV-1 infection in vitro is characterized by increased protein and RNA syntheses and infectious virus release Specific ablation of antiviral gene expression in macrophages by antibodydependent enhancement of ross river virus infection Suppression of antiviral responses by antibody-dependent enhancement of macrophage infection The role of IL-10 in promoting disease progression in leishmaniasis Interleukin 10-and Fcgamma receptor-deficient mice resolve Leishmania mexicana lesions Antibody-dependent enhancement of infection: a mechanism for indirect virus entry into cells Antibody-dependent enhancement of virus infection and disease Neutralization and antibody dependent enhancement of dengue viruses Antibody-mediated enhancement of viral disease Vaccine-induced enhancement of viral infections Antibodies determine virulence in dengue Persistence of circulating B memory cell clones with potential for dengue virus disease enhancement for decades following infection In-depth analysis of the antibody response of individuals exposed to primary dengue virus infection The human immune response to dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity Dengue virus neutralization by human immune sera: role of envelope protein domain III-reactive antibody Antibody-dependent Observations related to pathogenesis of dengue hemorrhagic fever Relation of disease severity to antibody response and virus recovered Evidence that maternal dengue antibodies are important in the development of dengue hemorrhagic fever in infants A prospective nested case-control study of dengue in infants: rethinking and refining the antibody-dependent enhancement dengue hemorrhagic fever model Maternal antibody and viral factors in the pathogenesis of dengue virus in infants Clinical and virological features of dengue in Vietnamese infants Dengue virus infections and maternal antibody decay in a prospective birth cohort study of Vietnamese infants Dengue in Vietnamese infants-results of infection-enhancement assays correlate with agerelated disease epidemiology, and cellular immune responses correlate with disease severity Shock associated with dengue infection.


id: cord-290385-0smnl70i
author: Chan, Jasper F.W.
title: Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease
date: 2016-03-03
extension: .txt
mime: text/plain
words: 8262
sentence: 319
flesch: 36
cache: cache/cord-290385-0smnl70i.txt
txt: txt/cord-290385-0smnl70i.txt
summary:
  Domain III peptides from flavivirus envelope protein are useful antigens for serologic diagnosis and targets for immunization A single mutation in chikungunya virus affects vector specificity and epidemic potential Spread of the pandemic Zika virus lineage is associated with NS1 codon usage adaptation in humans Biology of Zika virus infection in human skin cells Autophagy and viral diseases transmitted by Aedes aegypti and Aedes albopictus Zika virus infection of the central nervous system of mice Zika virus: further isolations in the Zika area, and some studies on the strains isolated Persistence of arboviruses and antiviral antibodies in vertebrate hosts: its occurrence and impacts Incubation periods of mosquito-borne viral infections: a systematic review Rapid risk assessment: Zika virus infection outbreak, French Polynesia Current Zika virus epidemiology and recent epidemics Zika virus outbreak Zika virus infection in man Zika virus infection, Cambodia Fatal Zika virus infection in girl with sickle cell disease, Colombia. Zika situation report e neurological syndrome and congenital anomalies Zika virus infection acquired during brief travel to Indonesia First case of Zika virus infection in a returning Canadian traveler Two cases of Zika fever imported from French Polynesia to Japan First case of laboratory-confirmed Zika virus infection imported into Europe Zika virus infection after travel to Tahiti Zika virus infection in a traveller returning to Europe from Brazil Zika virus infections imported to Italy: clinical, immunological and virological findings, and public health implications Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase Zika virus in an American recreational traveler Acute Zika virus infection after travel to Malaysian Borneo Zika fever imported from Thailand to Japan, and diagnosed by PCR in the urines Zika virus infection in a traveller returning from the Maldives Epidemiological alert e neurological syndrome, congenital malformations, and Zika virus infection.


id: cord-320091-2lrqubdl
author: Badawi, Alaa
date: 2018-07-10
extension: .txt
mime: text/plain
words: 8525
sentence: 366
flesch: 44
cache: cache/cord-320091-2lrqubdl.txt
txt: txt/cord-320091-2lrqubdl.txt
title:
  Prevalence of chronic comorbidities in dengue fever and West Nile virus: A systematic review and meta-analysis

summary:
  ORs of severe flavivirus diseases were about 2 to 4 in infected patients with comorbidities such as diabetes, hypertension and heart diseases. Currently, our knowledge of the host-related factors that influence the pathogenesis of severe disease is inadequate to allow prediction of who will develop severe clinical illness.


id: cord-282204-j1slaefb
author: Silva, José V.J.
date: 2018-12-31
extension: .txt
mime: text/plain
words: 8022
sentence: 224
flesch: 25
cache: cache/cord-282204-j1slaefb.txt
txt: txt/cord-282204-j1slaefb.txt
title:
  A scoping review of Chikungunya virus infection: epidemiology, clinical characteristics, viral co-circulation complications, and control

summary:
  Empirically-or reverse-engineered attenuated live vaccines, however, have been shown to be capable of inducing both cellular and humoral immune responses and have also been suggested to prevent CHIKV infection (Levitt et al., 1986; Wang et al., 2008 Wang et al., , 2011 Plante et al., 2011; Gorchakov et al., 2012; García-Arriaza et al., 2014) . In addition to classical attenuation via serial viral passage in cells, reverse genetics strategies have been employed as platforms for construction of recombinant attenuated viruses or vaccine chimeras (Wang et al., 2008; Plante et al., 2011; Wang et al., 2011; García-Arriaza et al., 2014; van den Doel et al., 2014; Erasmus et al., 2017 ).


id: cord-278260-3o91v72a
author: Halstead, Scott B
title: COVID 19 Vaccines: Should we fear ADE?
date: 2020-08-12
extension: .txt
mime: text/plain
words: 2334
sentence: 88
flesch: 31
cache: cache/cord-278260-3o91v72a.txt
txt: txt/cord-278260-3o91v72a.txt
summary:
  I. Clinical and physiologic manifestations of dengue hemorrhagic fever in Thailand Immunologic enhancement of dengue virus replication In vivo enhancement of dengue virus infection in Rhesus monkeys by passively transferred antibody Pathologic highlights of dengue hemorrhagic fever in 13 autopsy cases from Myanmar The Good, the Bad, and the Shocking: The Multiple Roles of Dengue Virus Nonstructural Protein 1 in Protection and Pathogenesis Association of Endothelial Glycocalyx and Tight and Adherens Junctions with Severity of Plasma Leakage in Dengue Infection Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components Dengue in Vietnamese infants--results of infectionenhancement assays correlate with age-related disease epidemiology, and cellular immune responses correlate with disease severity A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice Pathogenesis of feline infectious peritonitis: nature and development of viremia Atypical measles in children previously immunized with inactivated measles virus vaccines Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population Production of atypical measles in rhesus macaques: evidence for disease mediated by immune complex formation and eosinophils in the presence of fusion-inhibiting antibody Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins Anti-SARS-CoV IgG response in relation to disease severity of severe acute respiratory syndrome Anti-severe acute respiratory syndrome coronavirus spike antibodies trigger infection of human immune cells via a pH-and cysteine protease-independent FcgammaR pathway Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand.


id: cord-270495-2u072mtp
author: Lokida, Dewi
title: Diagnosis of COVID-19 in a Dengue-Endemic Area
date: 2020-08-05
extension: .txt
mime: text/plain
words: 1750
sentence: 82
flesch: 48
cache: cache/cord-270495-2u072mtp.txt
txt: txt/cord-270495-2u072mtp.txt
summary:
  A novel coronavirus from patients with pneumonia in China Coinfection between dengue and COVID-19: need for approach in endemic zones Covert COVID-19 and false-positive dengue serology in Singapore Force of infection and true infection rate of dengue in Singapore: implications for dengue control and management Dengue viral infection in Indonesia: epidemiology, diagnostic challenges, and mutations from an observational cohort study Clinical and laboratory diagnosis of dengue virus infection The epidemiology, virology and clinical findings of dengue virus infections in a cohort of Indonesian adults in western Java Prolonged persistence of IgM against dengue virus detected by commonly used commercial assays Accuracy of dengue clinical diagnosis with and without NS1 antigen rapid test: comparison between human and Bayesian network model decision COVID-19 and dengue co-infection in a returning traveller To estimate the extent of this problem, we evaluated sera from 42 confirmed COVID-19 patients for evidence of DENV infection.


id: cord-272459-w14finxf
author: Heaton, Nicholas S.
title: Dengue Virus and Autophagy
date: 2011-08-04
extension: .txt
mime: text/plain
words: 3118
sentence: 152
flesch: 37
cache: cache/cord-272459-w14finxf.txt
txt: txt/cord-272459-w14finxf.txt
summary:
  Regulation mechanisms and signaling pathways of autophagy Autophagy: Basic principles and relevance to disease Autophagy: Process and function A comprehensive glossary of autophagyrelated molecules and processes The origin of the autophagosomal membrane The beclin 1-vps34 complex-At the crossroads of autophagy and beyond LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing Physiological role of autophagy as an intracellular recycling system: With an emphasis on nutrient metabolism Viruses and autophagy MyD88 and Trif target beclin 1 to trigger autophagy in macrophages Toll-like receptors in control of immunological autophagy Multiple regulatory and effector roles of autophagy in immunity Autophagy-dependent viral recognition by plasmacytoid dendritic cells Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy Autophagy promotes mhc class ii presentation of peptides from intracellular source proteins Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes Subversion of the cellular autophagy pathway by viruses Modification of cellular autophagy protein LC3 by poliovirus Potential subversion of autophagosomal pathway by picornaviruses Autophagosome supports coxsackievirus B3 replication in host cells Coronaviruses Hijack the LC3-I-positive edemosomes, ER-derived vesicles exporting short-lived ERAD regulators, for replication Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response The autophagy machinery is required to initiate hepatitis C virus replication Activation of the unfolded protein response and autophagy after hepatitis c virus infection suppresses innate antiviral immunity in vitro Dengue and dengue hemorrhagic fever Dengue-Clinical and public health ramifications Dissecting the cell entry pathway of dengue virus by single-particle tracking in living cells Dengue virus ensures its fusion in late endosomes using compartment-specific lipids Recent advances in deciphering viral and host determinants of dengue virus replication and pathogenesis Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis Autophagic machinery activated by dengue virus enhances virus replication A role for autophagolysosomes in dengue virus 3 production in HepG2 cells Co-localization of constituents of the dengue virus translation and replication machinery with amphisomes Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication Composition and three-dimensional architecture of the dengue virus replication and assembly sites Modification of intracellular membrane structures for virus replication Dikic, I. A role for ubiquitin in selective autophagy Autophagy regulates lipid metabolism Dengue virus-induced autophagy regulates lipid metabolism Multifaceted roles for lipids in viral infection We would like to thank Kristi Berger for critical reading of the manuscript. Autophagy can act as an anti-viral component of the innate immune system, presumably by sequestering and degrading viral structures in the cells to help reduce viral replication.


id: cord-253480-qchrw337
author: Pu, Jieying
title: Antiviral activity of Carbenoxolone disodium against dengue virus infection
date: 2016-12-23
extension: .txt
mime: text/plain
words: 5320
sentence: 242
flesch: 49
cache: cache/cord-253480-qchrw337.txt
txt: txt/cord-253480-qchrw337.txt
summary:
  Here, we found that the production of infectious DENV particles was significantly decreased by CBX treatment in DENV‐permissive cells, while the viral RNA and viral protein synthesis were not affected. Furthermore, DENV RNA from progeny virions in the supernatants was significantly decreased by CBX treatment in a dose‐dependent manner.


id: cord-002426-5e1xn7kj
author: Falcón-Lezama, Jorge Abelardo
date: 2017-02-22
extension: .txt
mime: text/plain
words: 5948
sentence: 211
flesch: 43
cache: cache/cord-002426-5e1xn7kj.txt
txt: txt/cord-002426-5e1xn7kj.txt
title:
  Analysis of spatial mobility in subjects from a Dengue endemic urban locality in Morelos State, Mexico

summary:
  There was no significant difference between cases and population controls, regardless of age. b) Cases vs. population controls.


id: cord-294842-aesiff1f
author: Romero-Brey, Inés
title: Membranous Replication Factories Induced by Plus-Strand RNA Viruses
date: 2014-07-22
extension: .txt
mime: text/plain
words: 11053
sentence: 419
flesch: 35
cache: cache/cord-294842-aesiff1f.txt
txt: txt/cord-294842-aesiff1f.txt
summary:
  In addition, after multiple rounds of virus replication, tubular structures were also observed in the vicinity of VPs. As discussed earlier [119] , amongst these viruses two main architectures of remodeled membranes (morphotypes) can be found that may reflect two alternative strategies to induce the membranous microenvironments required to allow virus replication (summarized in Table 1 ).


id: cord-297662-slmlhqnb
author: Yap, Sally S. L.
title: Dengue Virus Glycosylation: What Do We Know?
date: 2017-07-25
extension: .txt
mime: text/plain
words: 11150
sentence: 341
flesch: 36
cache: cache/cord-297662-slmlhqnb.txt
txt: txt/cord-297662-slmlhqnb.txt
summary:
  Finally, N153 deglycosylated (N153 − ) DENV mutant displayed reduced infectivity (10-fold lower) in both mammalian and mosquito cells compared to WT, possibly due to impaired virus entry process (Lee et al., 1997; Hacker et al., 2009) , whereby loss of the N153-glycan affected the conformational stability of E proteins and led to premature exposure of the fusion peptide (Yoshii et al., 2013) . Instead, loss of the N67glycosylation site through site directed mutagenesis (N67Q) in E protein was sufficient to render DENV2 (strain 16681) growth defective in BHK-21 cells, a DC-SIGN(−) cell line (Bryant et al., 2007) .


id: cord-011012-5mev3otu
author: Rathore, Abhishek Singh
title: Production and immunogenicity of Fubc subunit protein redesigned from DENV envelope protein
date: 2020-03-30
extension: .txt
mime: text/plain
words: 6735
sentence: 217
flesch: 42
cache: cache/cord-011012-5mev3otu.txt
txt: txt/cord-011012-5mev3otu.txt
summary:
  It was observed by ELISA that Fubc fusion protein elicited higher serum IgG antibody response either in the presence or in absence of Freund’s adjuvant in comparison to the immune response of Fu and bc peptides separately. In this study, an alignment of the domain II amino acid sequences of DENV1-4 envelope proteins spanning residues from 61 to 120 was used to find optimum conserved sequence for the development of Fubc fusion protein (Fig. 1a) .


id: cord-011390-98xyie7s
author: Darcy, Andrew Waleluma
title: Multiple arboviral infections during a DENV-2 outbreak in Solomon Islands
date: 2020-05-15
extension: .txt
mime: text/plain
words: 4551
sentence: 201
flesch: 49
cache: cache/cord-011390-98xyie7s.txt
txt: txt/cord-011390-98xyie7s.txt
summary:
  Molecular Evolutionary Genetics Analysis Version 7.0 for bigger datasets Estimates of dengue force of infection in children in Colombo Estimation of infectious disease parameters from serological survey data: the impact of regular epidemics Contribution of dengue fever to the burden of acute febrile illnesses in Papua New Guinea: an age-specific prospective study Dengue seroprevalence, seroconversion and risk factors in Dhaka Incidence of dengue virus infection in adults and children in a prospective longitudinal cohort in the Philippines Seroprevalence of antibodies to dengue and chikungunya viruses in Thailand Interactions between serotypes of dengue highlight epidemiological impact of cross-immunity Cross-protective immunity can account for the alternating epidemic pattern of dengue virus serotypes circulating in Bangkok Prior dengue virus infection and risk of Zika: a pediatric cohort in Nicaragua Isolation of Zika virus imported from Tonga into Australia Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection DHF Epidemics in Cuba, 1981 and 1997: some interesting observations: WHO Regional Office for South-East Asia Molecular mechanisms involved in antibodydependent enhancement of dengue virus infection in humans Comparison of two rapid diagnostic tests during a large dengue virus serotype 3 outbreak in the Solomon Islands in 2013 The diagnostic and prognostic value of dengue non-structural 1 antigen detection in a hyper-endemic region in Indonesia Evaluation of dengue NS1 antigen detection tests with acute sera from patients infected with dengue virus in Venezuela Dengue viruses in Papua New Guinea: evidence of endemicity and phylogenetic variation, including the evolution of new genetic lineages Analysis of genotype diversity and evolution of dengue virus serotype 2 using complete genomes Increasing airline travel may facilitate co-circulation of multiple dengue virus serotypes in Asia Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations


id: cord-277547-2vim1wno
author: Zandi, Keivan
title: Antiviral activity of four types of bioflavonoid against dengue virus type-2
date: 2011-12-28
extension: .txt
mime: text/plain
words: 4387
sentence: 193
flesch: 47
cache: cache/cord-277547-2vim1wno.txt
txt: txt/cord-277547-2vim1wno.txt
summary:
  Anti-dengue activity of these compounds was determined at different stages of DENV-2 infection and replication cycle. Although there was no significant direct virucidal activity against DENV-2 by quercetin, continuous treatment of cells from 5 h before virus infection up to 4 days post-infection exhibited anti-dengue activity with IC 50 = 28.9 μg mL -1


id: cord-274129-vaygaqe5
author: Cheng, Ming Soon
date: 2015-08-15
extension: .txt
mime: text/plain
words: 4670
sentence: 173
flesch: 44
cache: cache/cord-274129-vaygaqe5.txt
txt: txt/cord-274129-vaygaqe5.txt
title:
  Impedimetric cell-based biosensor for real-time monitoring of cytopathic effects induced by dengue viruses

summary:
  Cells were allowed to proliferate in an incubator at 37°C with 5% CO 2 for 18 h. Subsequently, 500 μL of DENV-2 stock solution was added and mixed gently with cell medium. Cells were washed once with 5 mL of 1 Â DPBS, 3 mL of 1 Â trypsin-EDTA was added, and incubated at 37°C with 5% CO 2 for 5 min until cells detached.


id: cord-318614-518giv0m
author: Tsai, Jih-Jin
date: 2019-07-10
extension: .txt
mime: text/plain
words: 4829
sentence: 162
flesch: 42
cache: cache/cord-318614-518giv0m.txt
txt: txt/cord-318614-518giv0m.txt
title:
  A fully automated sample-to-answer PCR system for easy and sensitive detection of dengue virus in human serum and mosquitos

summary:
  The semi-automated POCKIT combo system includes an automated taco mini for nucleic acid extraction and a POCKIT device for PCR detection. Sample info and test results of mosquito samples with pan-DENV RT-iiPCR on fully automated POCKIT Central system and semi-automated POCKIT combo system.


id: cord-300648-ixiam7qr
author: Zhu, Xun
title: IFITM3‐containing exosome as a novel mediator for anti‐viral response in dengue virus infection
date: 2014-08-30
extension: .txt
mime: text/plain
words: 8303
sentence: 273
flesch: 40
cache: cache/cord-300648-ixiam7qr.txt
txt: txt/cord-300648-ixiam7qr.txt
summary:
  In the context, therefore, it would be of great interest to further investigate the biogenesis of IFITM3 exosome as well as its regulation, which might provide important clues for a rationale development of optimal anti-viral strategies. To evaluate the role of IFITM proteins in DENV infection, we generated permanent cell lines stably overexpressing human IFITM 1, 2 or 3, or control vector, respectively, with U937 and HeLa cells ( Fig.


id: cord-318120-vfznyyz6
author: Dauner, Allison L.
date: 2015-05-15
extension: .txt
mime: text/plain
words: 5272
sentence: 193
flesch: 39
cache: cache/cord-318120-vfznyyz6.txt
txt: txt/cord-318120-vfznyyz6.txt
title:
  Development of a pan-serotype reverse transcription loop-mediated isothermal amplification assay for the detection of dengue virus

summary:
  Wallingford: CAB International Dengue and dengue hemorrhagic fever Development of simple and rapid assay to detect viral RNA of tick-borne encephalitis virus by reverse transcription-loop-mediated isothermal amplification Rapid identification of dengue virus isolates by using monoclonal antibodies in an indirect immunofluorescence assay Development and evaluation of a novel loop-mediated isothermal amplification method for rapid detection of severe acute respiratory syndrome coronavirus Highly sensitive detection of malaria parasitemia in a malaria-endemic setting: performance of a new loop-mediated isothermal amplification kit in a remote clinic in Uganda Loop-mediated isothermal amplification for direct detection of Mycobacterium tuberculosis complex, M. avium, and M. intracellulare in sputum samples Rapid detection of dengue viral RNA in mosquitoes by nucleic acid-sequence based amplification (NASBA) Tolerance of loop-mediated isothermal amplification to a culture medium and biological substances Laboratory diagnosis of dengue virus infection: current and future perspectives in clinical diagnosis and public health Comparison of methods for extraction of nucleic acid from hemolytic serum for PCR amplification of hepatitis B virus DNA sequences A real-time reverse transcription loop-mediated isothermal amplification assay for the rapid detection of yellow fever virus A simple, inexpensive device for nucleic acid amplification without electricity-toward instrument-free molecular diagnostics in low-resource settings Simultaneous detection and differentiation of dengue virus serotypes 1-4, Japanese encephalitis virus, and West Nile virus by a combined reverse-transcription loop-mediated isothermal amplification assay Rapid identification of dengue virus by reverse transcription-polymerase chain reaction using field-deployable instrumentation The Direct Boil-LAMP method: a simple and rapid diagnostic method for cutaneous leishmaniasis Detection of loop-mediated isothermal amplification reaction by turbidity derived from magnesium pyrophosphate formation Real-time turbidimetry of LAMP reaction for quantifying template DNA Loop-mediated isothermal amplification reaction using a nondenatured template Accelerated reaction by loop-mediated isothermal amplification using loop primers Rapid detection and differentiation of dengue virus serotypes by NS1 specific reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay in patients presenting to a tertiary care hospital in Loopmediated isothermal amplification of DNA Real-time reverse transcription loopmediated isothermal amplification for rapid detection of West Nile virus Rapid detection and differentiation of dengue virus serotypes by a real-time reverse transcription-loopmediated isothermal amplification assay Development and evaluation of reverse transcription-loop-mediated isothermal amplification assay for rapid and real-time detection of Japanese encephalitis virus Rapid and sensitive detection of Macrobrachium rosenbergii nodavirus in giant freshwater prawns by reverse transcription loop-mediated isothermal amplification combined with a lateral flow dipstick Microevolution and virulence of dengue viruses Loop-mediated isothermal amplification assay for rapid diagnosis of malaria infections in an area of endemicity in Thailand Current advances in dengue diagnosis Simultaneous multiple target detection in real-time loop-mediated isothermal amplification Trends in dengue diagnosis Detection of dengue viruses using reverse transcription-loop-mediated isothermal amplification Rapid detection and quantification of Japanese encephalitis virus by real-time reverse transcription loop-mediated isothermal amplification The molecular epidemiology of Dengue viruses, genetic variation and microevolution The molecular epidemiology of dengue viruses, genetic variation and microevolution Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity This work would not have been possible without the generous support of the Ministry of Health Peru, Direccion General de Epidemiologia and DIRESA Piura, Tumbes, Madre de Dios, and Iquitos. In conclusion, this work adds to the growing body of isothermal amplification assays available to detect DENV.


id: cord-002581-r7mskri0
author: Magnani, Diogo M.
title: A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus
date: 2017-06-12
extension: .txt
mime: text/plain
words: 5299
sentence: 240
flesch: 50
cache: cache/cord-002581-r7mskri0.txt
txt: txt/cord-002581-r7mskri0.txt
summary:
  Ultrasound Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise Possible Association Between Zika Virus Infection and Microcephaly-Brazil Interim Guidelines for the Evaluation and Testing of Infants with Possible Congenital Zika Virus Infection-United States Interim Guidelines for Pregnant Women During a Zika Virus Outbreak-United States Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning IgBLAST: an immunoglobulin variable domain sequence analysis tool IMGT/V-QUEST: Zika virus (ZIKV) belongs to the genus Flavivirus of the Flaviviridae family and is related to dengue virus (DENV), yellow fever virus (YFV), Japanese encephalitis virus (JEV), and west Nile virus (WNV)


id: cord-273388-615acz0l
author: He, Miao
title: The Impact of Emerging Infectious Diseases on Chinese Blood Safety()
date: 2016-11-04
extension: .txt
mime: text/plain
words: 7071
sentence: 326
flesch: 49
cache: cache/cord-273388-615acz0l.txt
txt: txt/cord-273388-615acz0l.txt
summary:
  Novel approach for detection of hepatitis E virus infection in German blood donors Transmission of hepatitis E virus by transfusion: what is the risk? Seroprevalence of hepatitis E virus infection, rural southern People's Republic of China Swine as a principal reservoir of hepatitis E virus that infects humans in eastern China Serological and molecular study of hepatitis E virus among illegal blood donors Prevalence of hepatitis E virus in Chinese blood donors The global distribution and burden of dengue Dengue viremia in blood donors identified by RNA and detection of dengue transfusion transmission during the 2007 dengue outbreak in Puerto Rico Probable and possible transfusion-transmitted dengue associated with NS1 antigen-negative but RNA confirmed-positive red blood cells Detection of dengue virus in sera of Brazilian blood donors Prevalence of antidengue immunoglobulin G antibodies among American Red Cross blood donors in Puerto Rico Dynamic spatiotemporal trends of dengue transmission in the Asia-Pacific region Dengue fever in mainland China A study of seroprevalence and rates of asymptomatic viremia of severe fever with thrombocytopenia syndrome virus among Chinese blood donors Seroprevalence and risk factors for severe fever with thrombocytopenia syndrome virus infection in Severe fever with thrombocytopenia syndrome virus Antibodies against severe fever with thrombocytopenia syndrome virus in healthy persons, China Science, medicine, and the future: leishmaniasis Leishmania braziliensis in blood 30 years after cure Leishmania donovani transmission by packed RBC transfusion to anemic dogs in the United States Transmission of visceral leishmaniasis through blood transfusions from infected English foxhounds to anemic dogs Cutaneous leishmaniasis, cutaneous-ganglionic leishmaniasis, and transfusional kala-azar Visceral leishmaniasis in an infant in Brittany: discussion on the modes of transmission out endemic zones Visceral leishmaniasis after cardiac surgery Survivability and infectivity of viscerotropic Leishmania tropica from operation desert storm participants in human blood products maintained under blood bank conditions Asymptomatic infection by Leishmania infantum in blood donors from the Balearic Islands (Spain) Detection of Leishmania infantum cryptic infection in asymptomatic blood donors living in an endemic area (Eivissa, Balearic Islands, Spain) by different diagnostic methods Asymptomatic Leishmania infantum/chagasi infection in blood donors of western Sicily Serological screening for Leishmania infantum in asymptomatic blood donors living in an endemic area Occurrence of Leishmania infantum parasitemia in asymptomatic blood donors living in an area of endemicity in southern France Current epidemiological profile and features of visceral leishmaniasis in people's Republic of China Major trends in human parasitic diseases in China Q fever as a biological weapon Q fever: a biological weapon in your backyard Chronic Q fever: diagnosis and follow-up Host factors in the severity of Q fever Q fever and HIV infection Postinfection fatigue syndrome following Q fever Q fever in the Netherlands: an update on the epidemiology and control measures Coxiella burnetii infection among blood donors during the 2009 Q-fever outbreak in the Netherlands Screening of blood donors for chronic Coxiella burnetii infection after large Q fever outbreaks Progress of Q-fever epidemiological research in China Molecular epidemiology investigation for Q-fever in northeast of China Sero-investigation of Q-fever among different population and livestock in Anhui Province Q-fever detection on antibody of one causal fever Blood donation in China: sustaining efforts and challenges in achieving safety and availability Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China Probable limited person-to-person transmission of highly pathogenic avian influenza a (H5N1) virus in China Transfusion-transmitted dengue and associated clinical symptoms during the 2012 epidemic in Brazil Evidence for transmission of Zika virus by platelet transfusion Survey of blood collection centers and implementation of guidance for prevention of transfusion-transmitted Zika virus infection-Puerto Rico First case of laboratoryconfirmed Zika virus infection imported into China Early detection of Zika virus infection among travellers from areas of ongoing transmission in China Clearance of dengue virus in the plasma-derived therapeutic proteins Nile virus and the safety of plasma derivatives: verification of high safety margins, and the validity of predictions based on model virus data Quantitative evaluation of plasma after methylene blue and white light treatment in four Chinese blood centers The authors acknowledge Dr Hua Shan and Dr Ling Shi for their careful review of the paper.


id: cord-002179-v8lpw4r7
author: Viktorovskaya, Olga V.
date: 2016-08-24
extension: .txt
mime: text/plain
words: 8043
sentence: 301
flesch: 41
cache: cache/cord-002179-v8lpw4r7.txt
txt: txt/cord-002179-v8lpw4r7.txt
title:
  Identification of RNA Binding Proteins Associated with Dengue Virus RNA in Infected Cells Reveals Temporally Distinct Host Factor Requirements

summary:
  [13] exploited a cross-linking label-free MS approach to identify DENV RNA associating proteins in cell culture by cross-linking the RNA to the proteins using short wavelength UV light and isolating DENV RNA bound proteins by anti-sense DNA affinity capture [74] . The overall down-regulation of RNA binding proteins appears to be driven by changes in cytoplasmic and mitochondrial ribosomal subunits, and proteins involved in RNA degradation and processing (S5 Fig).


id: cord-286255-ded5t1ai
author: Tomashek, Kay M.
date: 2017-09-13
extension: .txt
mime: text/plain
words: 6148
sentence: 263
flesch: 50
cache: cache/cord-286255-ded5t1ai.txt
txt: txt/cord-286255-ded5t1ai.txt
title:
  Clinical and epidemiologic characteristics of dengue and other etiologic agents among patients with acute febrile illness, Puerto Rico, 2012–2015

summary:
  A higher proportion of participants with dengue reported having a household member with dengue at enrollment than participants with other diagnoses (11.8% of dengue cases versus 5% in other diagnostic groups, p <0.001). Participants with laboratory-positive dengue presented later (median = 3 days), and a higher proportion were admitted at enrollment than participants with other laboratory diagnoses; nearly half (46.6%) of dengue cases were admitted compared with 27.3% of participants with ORV illness, 18.8% with influenza, and 11.2% with chikungunya.


id: cord-033331-giku34r9
author: Manrique-Saide, Pablo
date: 2020-10-08
extension: .txt
mime: text/plain
words: 9926
sentence: 444
flesch: 43
cache: cache/cord-033331-giku34r9.txt
txt: txt/cord-033331-giku34r9.txt
title:
  The TIRS trial: protocol for a cluster randomized controlled trial assessing the efficacy of preventive targeted indoor residual spraying to reduce Aedes-borne viral illnesses in Merida, Mexico

summary:
  Poorly designed evaluations, a historical lack of focus on quantifying intervention impact using epidemiological endpoints, and limited funding for large-scale randomized controlled trials with epidemiological endpoints have all contributed to the lack of rigorous, evidence-based, assessments of ABV vector control interventions [10, 15] . The analysis will adopt recently developed methods for cluster randomized vector control trials


id: cord-256732-md1u51va
author: Shrivastava, Gaurav
title: Inflammasome Fuels Dengue Severity
date: 2020-09-10
extension: .txt
mime: text/plain
words: 8891
sentence: 284
flesch: 28
cache: cache/cord-256732-md1u51va.txt
txt: txt/cord-256732-md1u51va.txt
summary:
  Transcriptome meta-analysis reveals a dysregulation in extra cellular matrix and cell junction associated gene signatures during Dengue virus infection Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation Cutting edge: NF-κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination The global distribution and burden of dengue Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity Refining the global spatial limits of dengue virus transmission by evidence-based consensus Microbial translocation is a cause of systemic immune activation in chronic HIV infection Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus Spleen tyrosine kinase (Syk) mediates IL-1β induction by primary human monocytes during antibody-enhanced dengue virus infection Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2 Production of interleukin-l (il-l) and ill inhibitor by human monocytes exposed to dengue virus Dengue virus nonstructural protein 1 induces vascular leakage through macrophage migration inhibitory factor and autophagy Response of host inflammasomes to viral infection Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps CLEC5A is critical for dengue-virus-induced lethal disease Activation of terminally differentiated human monocytes/macrophages by dengue virus: productive infection, hierarchical production of innate cytokines and chemokines, and the synergistic effect of lipopolysaccharide Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-α production by mononuclear phagocytes Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection Inflammatory monocytes drive influenza Lipopolysaccharide acts synergistically with the dengue virus to induce monocyte production of platelet activating factor and other inflammatory mediators Altered monocyte response to the dengue virus in those with varying severity of past dengue infection Antibody-dependent enhancement of severe dengue disease in humans Dengue virus envelope protein domain III induces pro-inflammatory signature and triggers activation of inflammasome Infection with the dengue RNA virus activates TLR9 signaling in human dendritic cells Mechanisms and functions of inflammasomes Increased circulating soluble cd14 is associated with high mortality in gram-negative septic shock The inflammasomes: mechanisms of activation and function Recombinant Dengue virus protein NS2B alters membrane permeability in different membrane models Role of nonstructural protein NS2A in flavivirus assembly High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever The helical domains of the stem region of dengue virus envelope protein are involved in both virus assembly and entry Interleukin-18 improves the early defence system against influenza virus infection by augmenting natural killer cell-mediated cytotoxicity Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease Inflammasome control of viral infection Converging roles of caspases in inflammasome activation, cell death and innate immunity Mosquito saliva: the hope for a universal arbovirus vaccine? The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease Aedes aegypti salivary protein aegyptin coinoculation modulates dengue virus infection in the vertebrate host Dengue virus serotype-2 interferes with the formation of neutrophil extracellular traps The flavivirus NS1 protein: Molecular and structural biology, immunology, role inpathogenesis and application asadiagnostic biomarker Immune response to dengue virus and prospects for a vaccine Elevated levels of interleukin-13 and IL-18 in patients with dengue hemorrhagic fever RIG-i, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection IL-1β production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease Circulating cytokines as mediators of fever Hyperactivation of the NLRP3 inflammasome protects mice against influenza A virus infection via IL-1β mediated neutrophil recruitment Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock Neutrophil activation and early features of net formation are associated with dengue virus infection in human Dengue virus M protein promotes NLRP3 inflammasome activation to induce vascular leakage in mice Dengue virus infection activates interleukin-1β to induce tissue injury and vascular leakage Of cascades and perfect storms:


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type: PERSON
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