item: #1 of 196 id: cord-000182-ni6iyzdn author: He, Zhisong title: Predicting Drug-Target Interaction Networks Based on Functional Groups and Biological Features date: 2010-03-11 words: 6042 flesch: 37 summary: All the detailed information for the genes and drugs listed here can be found in A guide to drug discovery: Target selection in drug discovery Predicting human safety: screening and computational approaches Assessment of chemical libraries for their druggability Review: Progress in computational approach to drug development against SARS 3D structure modeling of cytochrome P450 2C19 and its implication for personalized drug design Molecular modeling of two CYP2C19 SNPs and its implications for personalized drug design Review: Pharmacogenomics and personalized use of drugs Review: Structure of cytochrome P450s and personalized drug Structure-based maximal affinity model predicts small-molecule druggability A fast flexible docking method using an incremental construction algorithm Review: Structural bioinformatics and its impact to biomedical science Binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against SARS A probabilistic model for mining implicit 'chemical compound-gene' relations from literature Prediction of drug-target interaction networks from the integration of chemical and genomic spaces Statistical prediction of protein chemical interactions based on chemical structure and mass spectrometry data Integrating statistical predictions and experimental verifications for enhancing protein-chemical interaction predictions in virtual screening Alignment-free prediction of a drug-target complex network based on parameters of drug connectivity and protein sequence of receptors A vectorized sequence-coupling model for predicting HIV protease cleavage sites in proteins Review: Prediction of HIV protease cleavage sites in proteins GPCR-CA: A cellular automaton image approach for predicting G-protein-coupled receptor functional classes GPCR-GIA: a web-server for identifying Gprotein coupled receptors and their families with grey incidence analysis Signal-CF: a subsite-coupled and window-fusing approach for predicting signal peptides Using functional domain composition and support vector machines for prediction of protein subcellular location Cell-PLoc: A package of web-servers for predicting subcellular localization of proteins in various organisms Euk-mPLoc: a fusion classifier for large-scale eukaryotic protein subcellular location prediction by incorporating multiple sites A sequence-coupled vector-projection model for predicting the specificity of GalNAc-transferase ProtIdent: A web server for identifying proteases and their types by fusing functional domain and sequential evolution information Prediction of protease types in a hybridization space Prediction of membrane protein types and subcellular locations Low-frequency Fourier spectrum for predicting membrane protein types MemType-2L: A Web server for predicting membrane proteins and their types by incorporating evolution information through Pse-PSSM Support vector machines for predicting membrane protein types by using functional domain composition Review: recent advances in developing web-servers for predicting protein attributes A k-nearest neighbor classification rule based on Dempster-Shafer theory PredAcc: prediction of solvent accessibility Prediction of protein cellular attributes using pseudo amino acid composition Using amphiphilic pseudo amino acid composition to predict enzyme subfamily classes Digital coding of amino acids based on hydrophobic index Feature selection based on mutual information: criteria of max-dependency, max-relevance, and min-redundancy Insights from modelling three-dimensional structures of the human potassium and sodium channels The structure of phospholamban pentamer reveals a channel-like architecture in membranes Mechanism of drug inhibition and drug resistance of influenza A M2 channel Structure and mechanism of the M2 proton channel of influenza A virus Prediction of G-protein-coupled receptor classes Coupling interaction between thromboxane A2 receptor and alpha-13 subunit of guanine nucleotide-binding protein LIGAND: chemical database for enzyme reactions From genomics to chemical genomics: new developments in KEGG Predicting networking couples for metabolic pathways of Evaluating the statistical significance of multiple distinct local alignments A novel approach to predicting protein structural classes in a (20-1)-D amino acid composition space Prediction of protein secondary structure content by using the concept of Chou's pseudo amino acid composition and support vector machine Use of fuzzy clustering technique and matrices to classify amino acids and its impact to Chou's pseudo amino acid composition Using the concept of Chou's pseudo amino acid composition to predict apoptosis proteins subcellular location: an approach by approximate entropy Predicting protein subcellular location using Chou's pseudo amino acid composition and improved hybrid approach The modified Mahalanobis discriminant for predicting outer membrane proteins by using Chou's pseudo amino acid composition Predicting subcellular localization of mycobacterial proteins by using Chou's pseudo amino acid composition Prediction of Subcellular Localization of Apoptosis Protein Using Chou's Pseudo Amino Acid Composition Prediction of G-protein-coupled receptor classes based on the concept of Chou's pseudo amino acid composition: an approach from discrete wavelet transform Using the augmented Chou's pseudo amino acid composition for predicting protein submitochondria locations based on auto covariance approach Predicting the cofactors of oxidoreductases based on amino acid composition distribution and Chou's amphiphilic pseudo amino acid composition Predicting lipase types by improved Chou's pseudo-amino acid composition Using Chou's amphiphilic pseudoamino acid composition and support vector machine for prediction of enzyme subfamily classes Using Chou's pseudo amino acid composition to predict subcellular localization of apoptosis proteins: an approach with immune genetic algorithm-based ensemble classifier Prediction of cell wall lytic enzymes using Chou's amphiphilic pseudo amino acid composition Medicinal chemistry and bioinformatics -current trends in drugs discovery with networks topological indices Proteomics, networks, and connectivity indices Application of pseudo amino acid composition for predicting protein subcellular location: stochastic signal processing approach Weighted-support vector machines for predicting membrane protein types based on pseudo amino acid composition SLLE for predicting membrane protein types Using pseudo amino acid composition to predict protein structural classes: approached with complexity measure factor Using pseudo amino acid composition to predict protein subcellular location: approached with Lyapunov index, Bessel function, and Chebyshev filter Using cellular automata to generate Image representation for biological sequences Using cellular automata images and pseudo amino acid composition to predict protein subcellular location Using pseudo amino acid composition to predict transmembrane regions in protein: cellular automata and Lempel-Ziv complexity Using Pseudo Amino Acid Composition to Predict Protein Structural Class: Approached by Incorporating 400 Dipeptide Components Predicting protein structural classes with pseudo amino acid composition: an approach using geometric moments of cellular automaton image Using grey dynamic modeling and pseudo amino acid composition to predict protein structural classes Predicting membrane protein type by functional domain composition and pseudo amino acid composition Hum-PLoc: A novel ensemble classifier for predicting human protein subcellular localization Large-scale plant protein subcellular location prediction Predicting membrane protein types by the LLDA algorithm Predicting eukaryotic protein subcellular location by fusing optimized evidence-theoretic K-nearest neighbor classifiers Pseudo amino acid composition and its applications in bioinformatics, proteomics and system biology Recognition of a protein fold in the context of the Structural Classification of Proteins (SCOP) classification The classification and origins of protein folding patterns Seventy-five percent accuracy in protein secondary structure prediction Predicting protein folding types by distance functions that make allowances for amino acid interactions A fuzzy k-nearest neighbours algorithm Discriminant Analysis; Chapter 12 Multivariate analysis of variance On the generalized distance in statistics Although there are more features for target than those for drug in the original feature set, more drug features were selected, showing the important role of drugs. keywords: acid; amino; composition; drug; feature; information; interactions; prediction; protein; pseudo; sequence; set; structure; target cache: cord-000182-ni6iyzdn.txt plain text: cord-000182-ni6iyzdn.txt item: #2 of 196 id: cord-000204-hd12p867 author: Wu, Han-Chung title: Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy date: 2010-05-05 words: 4436 flesch: 28 summary: Coupling liposomes with peptides targeted to tumor cells or tumor vasculature further enhances the specificity and accumulation of liposomes in the tumor. On arrival in the tumor tissues, the liposomes are bound and internalized by tumor cells or tumor-associated endothelial cells through receptor-mediated endocytosis, fused with the low pH compartments of the endosomes, and subsequently broken down the liposomes and to release encapsulated drugs into the intracellular space of the cells. keywords: blood; cancer; cells; delivery; doxorubicin; drug; liposomes; peptide; tumor; vessels cache: cord-000204-hd12p867.txt plain text: cord-000204-hd12p867.txt item: #3 of 196 id: cord-001072-pjv3wy80 author: Hong, Xiaoyun title: Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine date: 2013-09-04 words: 4120 flesch: 31 summary: key: cord-001072-pjv3wy80 authors: Hong, Xiaoyun; Wei, Liangming; Wu, Fei; Wu, Zaozhan; Chen, Lizhu; Liu, Zhenguo; Yuan, Weien title: Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine date: 2013-09-04 journal: Drug Des Devel Ther DOI: 10.2147/dddt.s44401 sha: doc_id: 1072 cord_uid: pjv3wy80 Microneedles were first conceptualized for drug delivery many decades ago, overcoming the shortages and preserving the advantages of hypodermic needle and conventional transdermal drug-delivery systems to some extent. 8 Microneedle technologies, which were first conceptualized for drug delivery many decades ago, overcome the shortages and preserve the advantages of hypodermic needles and conventional transdermal drug-delivery systems to some extent. keywords: delivery; dissolving; dna; drug; microneedles; release; skin; transdermal; vaccine cache: cord-001072-pjv3wy80.txt plain text: cord-001072-pjv3wy80.txt item: #4 of 196 id: cord-001151-mdej7nhj author: Kumar De, Amit title: Application of an Amine Functionalized Biopolymer in the Colonic Delivery of Glycyrrhizin: A Design and In Vivo Efficacy Study date: 2013-05-18 words: 5117 flesch: 47 summary: In the simulated gastric and intestinal fluid, minimum drug release was observed and the rate of drug release was also very slow. The increase in drug release in the simulated colonic fluid was facilitated by the enzymatic degradation of the polymer and by the colonic microflora present in the rat cecal contents. keywords: colitis; colonic; delivery; drug; drug release; gam; group; guar; polymer; release; tissue cache: cord-001151-mdej7nhj.txt plain text: cord-001151-mdej7nhj.txt item: #5 of 196 id: cord-001244-qdld7hdc author: Fan, Yue-Nong title: iNR-Drug: Predicting the Interaction of Drugs with Nuclear Receptors in Cellular Networking date: 2014-03-19 words: 6509 flesch: 35 summary: A subcellular location predictor by incorporating term-frequency gene ontology into the general form of Chou's pseudo-amino acid composition Predicting protein subchloroplast locations with both single and multiple sites via three different modes of Chou's pseudo amino acid compositions Predicting membrane protein types by incorporating protein topology, domains, signal peptides, and physicochemical properties into the general form of Chou's pseudo amino acid composition A multilabel model based on Chou's pseudo-amino acid composition for identifying membrane proteins with both single and multiple functional types Genetic programming for creating Chou's pseudo amino acid based features for submitochondria localization Predicting protein submitochondria locations by combining different descriptors into the general form of Chou's pseudo amino acid composition Multi-kernel transfer learning based on Chou's PseAAC formulation for protein submitochondria localization Using the augmented Chou's pseudo amino acid composition for predicting protein submitochondria locations based on auto covariance approach Prediction of GABA(A) receptor proteins using the concept of Chou's pseudo-amino acid composition and support vector machine Using Chou's amphiphilic pseudo-amino acid composition and support vector machine for prediction of enzyme subfamily classes Predicting antibacterial peptides by the concept of Chou;s pseudo-amino acid composition and machine learning methods Supersecondary structure prediction using Chou's pseudo amino acid composition Identifying bacterial virulent proteins by fusing a set of classifiers based on variants of Chou's pseudo amino acid composition and on evolutionary information A novel feature representation method based on Chou's pseudo amino acid composition for protein structural class prediction Predicting the cofactors of oxidoreductases based on amino acid composition distribution and Chou's amphiphilic pseudo amino acid composition Prediction of metalloproteinase family based on the concept of Chou's pseudo amino acid composition using a machine learning approach SecretP: Identifying bacterial secreted proteins by fusing new features into Chou's pseudo-amino acid composition Prediction of allergenic proteins by means of the concept of Chou's pseudo amino acid composition and a machine learning approach Using Chou's pseudo amino acid composition to predict protein quaternary structure: A sequence-segmented PseAAC approach Identifying protein quaternary structural attributes by incorporating physicochemical properties into the general form of Chou's PseAAC via discrete wavelet transform Using the concept of Chou's pseudo amino acid composition for risk type prediction of human papillomaviruses Prediction of cyclin proteins using Chou's pseudo amino acid composition Discriminating outer membrane proteins with fuzzy K-nearest neighbor algorithms based on the general form of Chou's PseAAC Use of fuzzy clustering technique and matrices to classify amino acids and its impact to Chou's pseudo amino acid composition Protein remote homology detection by combining Chou's pseudo amino acid composition and profile-based protein representation Identification of colorectal cancer related genes with mRMR and shortest path in protein-protein interaction network Hepatitis C virus network based classification of hepatocellular cirrhosis and carcinoma Signal propagation in protein interaction network during colorectal cancer progression PseAAC-Builder: A cross-platform stand-alone program for generating various special Chou's pseudo-amino acid compositions Propy: A tool to generate various modes of Chou's PseAAC PseAAC: A flexible web-server for generating various kinds of protein pseudo amino acid composition The folding type of a protein is relevant to the amino acid composition An optimization approach to predicting protein structural class from amino acid composition Monte Carlo simulation studies on the prediction of protein folding types from amino acid composition Predicting protein folding types by distance functions that make allowances for amino acid interactions Monte Carlo simulation studies on the prediction of protein folding types from amino acid composition. To acquire the 3D structural information in a timely manner, one has to resort to various structural bioinformatics tools (see, e.g., [37] ), particularly the homologous modeling approach as utilized for a series of protein receptors urgently needed during the process of drug development [19, [52] keywords: acid; acid composition; amino; amino acid; approach; chou; composition; drug; pairs; prediction; protein; pseudo; pseudo amino; sequence cache: cord-001244-qdld7hdc.txt plain text: cord-001244-qdld7hdc.txt item: #6 of 196 id: cord-001470-hn288o97 author: Pivette, Mathilde title: Drug sales data analysis for outbreak detection of infectious diseases: a systematic literature review date: 2014-11-18 words: 4424 flesch: 48 summary: Most studies compared drug sales data to reference surveillance data using correlation measurements or indicators of outbreak detection performance (sensitivity, specificity, timeliness of the detection). Nineteen studies retrospectively compared drug sales data to reference clinical data, and significant correlations were observed in 17 of them. keywords: data; detection; disease; drug; health; outbreak; review; sales; studies; surveillance cache: cord-001470-hn288o97.txt plain text: cord-001470-hn288o97.txt item: #7 of 196 id: cord-002774-tpqsjjet author: None title: Section II: Poster Sessions date: 2017-12-01 words: 83566 flesch: 48 summary: The CHIP framework drives the complex inter-relationships between community-hospital engagement, reciprocal capacity-building, integration initiatives, and community-based research and evaluation, to create an interconnected network of health care services. Those living in urban centers should have the best ava1l~b1hty, chmce, and access to a variety of health care services because of the distribution of health care services, fac1lmes, and health professionals in concentrated in urban centers. keywords: access; address; age; aids; analysis; approach; areas; barriers; canada; cancer; care services; care system; case; child health; children; cities; city; clients; clinic; communities; community health; community services; conclusion; conditions; current; data; demographic; depression; development; disease; drug; education; effects; environmental; ethnic; experience; factors; family; findings; focus; food; government; group; health care; health centre; health education; health information; health insurance; health issues; health needs; health outcomes; health policy; health problems; health promotion; health research; health services; health status; health survey; health system; healthcare; help; hiv; homeless; hospital; housing; immigrants; impact; income; individuals; information; interventions; interviews; introduction; issues; key; knowledge; lack; level; life; living; low; medical; methods; model; mortality; national; neighborhood; new; non; number; paper; participants; patients; people; physical; poor; population; population health; poster; poverty; prevalence; prevention; primary; process; program; project; provide; providers; public; quality; rates; relationship; research; residents; resources; results; risk; role; sample; self; sessions; sexual; social; strategies; street; street health; studies; study; substance; support; survey; system; time; toronto; treatment; urban; use; users; women; work; workers; years; youth cache: cord-002774-tpqsjjet.txt plain text: cord-002774-tpqsjjet.txt item: #8 of 196 id: cord-003118-58ta20fg author: Van Norman, Gail A. title: Expanding Patient Access to Investigational New Drugs: Overview of Intermediate and Widespread Treatment Investigational New Drugs, and Emergency Authorization in Public Health Emergencies date: 2018-06-25 words: 2205 flesch: 28 summary: While these pathways provide potential access for individual patients to investigational drugs, different EA pathways permit entire groups of certain patients to access investigational drugs prior to FDA approval. This review focuses on special categories of EA INDs intended for multiple patients—the intermediate-group IND and the widespread-treatment IND—as well as emergency authorization for use of investigational drugs and biological products (e.g., vaccines) in public health emergencies. keywords: access; drug; fda; patients; treatment; use cache: cord-003118-58ta20fg.txt plain text: cord-003118-58ta20fg.txt item: #9 of 196 id: cord-004501-guiy89x8 author: Cojocaru, Florina-Daniela title: Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers date: 2020-02-18 words: 14004 flesch: 30 summary: A reality for diagnosis of HCV infectious disease HIV biosensors for early diagnosis of infection: The intertwine of nanotechnology with sensing strategies Chitosan as a bioactive polymer: Processing, properties and applications Anti-Herpes Simplex Virus (HSV-1 and HSV-2) activity of biogenic gold and silver nanoparticles using seaweed Sargassum wightii A novel extracellular synthesis of monodisperse gold nanoparticles using marine alga, Sargassum wightii Greville Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism Inhibition of Human Metapneumovirus Binding to Heparan Sulfate Blocks Infection in Human Lung Cells and Airway Tissues Pathogen Inhibition by Multivalent Ligand Architectures Surface-structureregulated cell-membrane penetration by monolayer-protected nanoparticles Antiherpes evaluation of soybean isoflavonoids Topical Delivery of Coumestrol from Lipid Nanoemulsions Thickened with Hydroxyethylcellulose for Antiherpes Treatment Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation Reverse Transcriptase Inhibitors Nanosystems Designed for Drug Stability and Controlled Delivery Novel dendritic structure of alginate hybrid nanoparticles for effective anti-viral drug delivery Design of antiretroviral drug-polymeric nanoparticles laden buccal films for chronic HIV therapy in paediatrics Influence of Solvent Evaporation Technique Parameters on Diameter of Submicron Lamivudine-Poly-ε-Caprolactone Conjugate Particles Nanoencapsulation of water-soluble drug, lamivudine, using a double emulsion spray-drying technique for improving HIV treatment Formulation and characterisation of chitosan based lamivudine nanoparticles The Antiretroviral Agent Nelfinavir Mesylate: A Potential Therapy for Systemic Sclerosis Inhibition of HIV Fusion with Multivalent Gold Nanoparticles Gold Nanoparticles as an HIV Entry Inhibitor Gold nanoparticles to improve HIV drug delivery The role of nanotechnology in the treatment of viral infections Epaxal ® : A virosomal vaccine to prevent hepatitis A infection Pharmacokinetics and Pharmacodynamics Modeling and Simulation Systems to Support the Development and Regulation of Liposomal Drugs Eleven years of Inflexal ® V-A virosomal adjuvanted influenza vaccine Package Insert PEG-IntronTM (Peginterferon alfa-2b) Powder for Injection, Schering Corporation Progress in Nanomedicine: Approved and Investigational Nanodrugs Tolerability and Immune Response to LC002, an Experimental Therapeutic Vaccine Bioavailability of MK-1439 Experimental Nano Formulations in Healthy Adults (MK-1439-046)-ClinicalTrials.gov There are several factors that hinder the development of antiviral drugs: • Dependence of viruses replication on host cell biosynthetic machinery keywords: activity; acv; antiviral; barrier; bbb; blood; brain; cell; costs; delivery; dna; drug; drug delivery; hiv; impact; infection; inhibitors; mechanism; membrane; nanoparticles; nanotechnology; nps; review; skin; studies; therapy; treatment; virus; viruses; vitro cache: cord-004501-guiy89x8.txt plain text: cord-004501-guiy89x8.txt item: #10 of 196 id: cord-006226-fn7zlutj author: None title: Abstracts of the 4th annual meeting of the German Society of Clinical Pharmacology and Therapy: Hannover, 14–17 September 1994 date: 1994 words: 25130 flesch: 47 summary: The effects were correlated with the %-~l-adrenoceptor occupancies estimated using a standard Emax-model (sigmoidicity=l) from the concentrations of active substrate in plasma determined by I~l-adrenoceptor specific radioreceptor assay. With regard to group I) the highest expenditures nccured in hospitals A and B whereas drug costs in C -E were 1/3 less and came to only 20% in hospital F. keywords: acid; activity; aggregation; blood; cell; clinical; concentrations; cost; data; disease; dose; drug; effects; excretion; function; group; hours; human; inhibition; mean; metabolites; method; min; patients; placebo; plasma; platelet; products; protein; rate; release; results; samples; serum; studies; study; therapy; time; total; treatment; urinary; urine; use; vitro; volunteers cache: cord-006226-fn7zlutj.txt plain text: cord-006226-fn7zlutj.txt item: #11 of 196 id: cord-006229-7yoilsho author: None title: Abstracts of the 82(nd) Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) and the 18(th) Annual Meeting of the Network Clinical Pharmacology Germany (VKliPha) in cooperation with the Arbeitsgemeinschaft für Angewandte Humanpharmakologie e.V. (AGAH) date: 2016-02-06 words: 134020 flesch: 40 summary: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC) and is characterized by a metabolic shift towards enhanced aerobic glycolysis and hence, increased lactate production. Further studies will be performed to clarify whether silver ions and/or silver nanoparticles could affect the specific N-acetylation of arylamines in human cells. keywords: acid; activation; activity; addition; agents; agonist; aim; analysis; animal; anti; approach; assay; assessment; background; barrier; binding; blood; body; brain; camp; cancer; cancer cells; cardiac; cell death; cell line; cells; cgmp; changes; channels; chemical; chronic; clinical; complex; compounds; concentrations; conclusion; conditions; contrast; control; culture; current; damage; data; days; death; development; differences; different; differentiation; disease; dna; dose; drug; e.g.; effects; endothelial; enzyme; experiments; exposure; expression; factor; fibroblasts; findings; flow; fold; food; formation; fret; function; g protein; gene; germany; group; growth; health; heart; human; impact; increase; induction; inflammation; influence; inhibition; inhibitors; insulin; interaction; intracellular; kidney; levels; line; liver; loss; low; lung; mcpd; mechanisms; membrane; metabolism; metabolites; methods; mice; migration; model; mouse; mrna; nanoparticles; neurons; new; non; novel; number; oct1; order; p<0.05; parameters; pathways; patients; phosphorylation; plasma; platelet; potential; presence; present; primary; processes; products; proliferation; properties; protein; protein expression; rats; receptor; receptor activation; reduced; reduction; regulation; release; research; resistance; response; results; risk; role; samples; set; signaling; skin; small; specific; stimulation; stress; studies; study; substances; system; target; test; testing; therapy; time; tissue; total; toxicity; transcription; treatment; tumor; type; uptake; vitro; vivo; vs.; weight cache: cord-006229-7yoilsho.txt plain text: cord-006229-7yoilsho.txt item: #12 of 196 id: cord-006479-iaocovf2 author: Schreiber, J. title: Medikamenteninduzierte parenchymatöse Lungenerkrankungen date: 2009-08-01 words: 1829 flesch: 28 summary: Die Therapie besteht in einer Medikamentenkarenz und der Applikation von Glukokortikosteroiden. In der BAL ist eine Lymphozytose (CD4+ oder CD8+) und im Lungenparenchym sind histologisch eine Alveolitis, Hyperplasie der Typ-II-Pneumozyten und granulomatöse Entzündung sowie eine geringe, nicht obligate Gewebseosinophilie nachweisbar. keywords: den; der; die; disease; drug; eine; ist; lung; mit; nebenwirkungen; oder; sind; therapie; und; von cache: cord-006479-iaocovf2.txt plain text: cord-006479-iaocovf2.txt item: #13 of 196 id: cord-007511-5d5authn author: Gil, JP title: CYP2C8 and antimalaria drug efficacy date: 2007-02-07 words: 6640 flesch: 42 summary: The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects The impact of CYP2C8 polymorphism and grapefruit juice on the pharmacokinetics of repaglinide Association of CYP2C8, CYP3A4, CYP3A5, and ABCB1 polymorphisms with the pharmacokinetics of paclitaxel The effects of human CYP2C8 genotype and fluvoxamine on the pharmacokinetics of rosiglitazone in healthy subjects Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y An integrated model of chloroquine action Physicochemical properties correlated with drug resistance and the reversal of drug resistance in Plasmodium falciparum Susceptibility of Colombian Plasmodium falciparum isolates to 4-aminoquinolines and the definition of amodiaquine resistance in vitro Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitro In vitro demonstration of the synergy between AQ and its main metabolite, desethylamodiaquine High-performance liquid chromatographic method for determination of amodiaquine, chloroquine and their monodesethyl metabolites in biological samples In vitro susceptibility of Gabonese wild isolates of Plasmodium falciparum to artemether, and comparison with chloroquine, quinine, halofantrine and amodiaquine In vitro activity of pyronaridine and amodiaquine against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial agents Evaluation under field conditions of the colourimetric DELI-microtest for the assessment of Plasmodium falciparum drug resistance In vitro activities of ferrochloroquine against 55 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs In vitro sensitivity of Plasmodium falciparum to amodiaquine compared with other major antimalarials in Madagascar The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria Plasmodium falciparum: in vitro interactions of artemisinin with amodiaquine, pyronaridine, and chloroquine Pharmacodynamic interactions of amodiaquine and its major metabolite desethylamodiaquine with artemisinin, quinine and atovaquone in Plasmodium falciparum in vitro Amodiaquine induced agranulocytosis and liver damage Systematic review of amodiaquine treatment in uncomplicated malaria • Review on the use of AQ for treatment Detection of antidrug IgG antibodies in patients with adverse drug reaction to amodiaquine Role of hepatic metabolism in the bioactivation and detoxification of amodiaquine The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: chemical mechanisms and the effects of fluorine substitution Amodiaquine for treating malaria • Authorative review of the use of AQ to treat malaria Artemisinin-based combination therapies (ACTs), best hope for malaria treatment but inaccessible to the needy! Induction of CYP2C genes in human hepatocytes in primary culture • Seminal paper on in vitro CYP2C induction driven by pregnane X receptor (PXR) and constitutive androstane receptor (CAR) ligands Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor • Artemisinin and its derivatives are in vitro PXR and CAR ligands In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin Examination of 209 drugs for inhibition of cytochrome P450 2C8 On the question of dose-dependent chloroquine elimination of a single oral dose Single dose pharmacokinetics of chloroquine and its main metabolite in healthy volunteers Pharmacokinetics of chloroquine and some of its metabolites in healthy volunteers: a single dose study Renal dysfunction in children with uncomplicated, Plasmodium falciparum malaria in Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial Chlorproguanil/dapsone for uncomplicated Plasmodium falciparum malaria in young children: pharmacokinetics and therapeutic range Mutations in dhfr in Plasmodium falciparum infections selected by chlorproguanildapsone treatment Development of dapsone toxicity in patients with inflammatory dermatoses: activity of acetylation and hydroxylation of dapsone as risk factors CYP2C8 polymorphism frequencies among malaria patients in Zanzibar • By combining it with published in vitro pharmacodynamic and drug metabolism information, we review and predict the possible relevance, or lack of, of CYP2C8 polymorphisms in the present and future efficacy of amodiaquine. keywords: amodiaquine; combination; cyp2c8; deaq; drug; efficacy; falciparum; malaria; resistance; vitro cache: cord-007511-5d5authn.txt plain text: cord-007511-5d5authn.txt item: #14 of 196 id: cord-007798-9ht7cqhu author: Smith, Silas W. title: Drugs and pharmaceuticals: management of intoxication and antidotes date: 2010-02-25 words: 22607 flesch: 29 summary: Similarly, restricting activated charcoal (AC) administration to patients presenting to health care within the first hour post ingestion would exclude up to 90% of poisoned patients from the potential benefits of AC when administered beyond an hour [24, 33] . A small retrospective chart review found no adverse effects or allergic reactions in VPA overdose patients administered carnitine keywords: acetaminophen; acid; acute; administration; benefit; bicarbonate; calcium; cardiac; carnitine; case; channel; charcoal; concentrations; digoxin; doses; drug; effects; glucose; hours; hypoglycemia; i.v; infusion; ingestion; insulin; intoxication; leucovorin; management; methotrexate; mtx; naloxone; octreotide; oral; overdose; patients; poisoning; serum; sodium; studies; study; therapy; toxicity; treatment; use cache: cord-007798-9ht7cqhu.txt plain text: cord-007798-9ht7cqhu.txt item: #15 of 196 id: cord-009763-44fexcpt author: Reddy, Mynampati Akshitha title: Internet-of-Things-Enabled Dual-Channel Iontophoretic Drug Delivery System for Elderly Patient Medication Management date: 2020-03-01 words: 5229 flesch: 52 summary: With the advent of technological advancements, it is quite feasible to develop electronically-controlled drug delivery systems, including iontophoretic drug delivery systems, at a cheap price. The main advantage of iontophoretic drug delivery is its ability to deliver drugs within the deeper layer of the skin tissue and/or systemic circulation in a noninvasive manner keywords: circuit; current; delivery; device; drug; drug delivery; fig; output; signal; system cache: cord-009763-44fexcpt.txt plain text: cord-009763-44fexcpt.txt item: #16 of 196 id: cord-014687-0am4l5ms author: None title: SPR 2012 date: 2012-03-29 words: 98702 flesch: 39 summary: Image Gently has succeeded not only in raising awareness of the great diagnostic benefits we can offer to pediatric patients but also directs us to acknowledge the downside of overzealous diagnostic efforts where excessive radiation becomes a risk. Methods & Materials: Pediatric patients who had high temporal resolution cine Steady State Free Precession sequence (50 frames acquired across a single cardiac cycle) performed as part of a MRI/MRA of the heart from 2005-2011 were included. keywords: abnormalities; acute; age; airway; anatomy; anomalies; appearance; approach; assessment; average; blood; body; bone; bowel; brain; brain mri; cardiac; care; case report; cases; center; chest; children; complications; conclusions; conditions; contrast; correlation; ct imaging; data; days; development; diagnosis; diffusion; disease; disorders; dose; evaluation; exhibit; fat; fetal; flow; follow; following; fractures; group; head; heart; high; hospital; images; imaging; imaging features; imaging findings; imaging modalities; imaging studies; infants; information; injury; institution; left; lesions; level; literature; liver; low; lung; malformations; management; mass; masses; materials; mean; medical; methods; months; mr imaging; mri; mri findings; neck; neonatal; new; noise; non; obstruction; pathology; patients; pediatric; population; post; posterior; potential; prenatal; present; presentation; protocol; pulmonary; purpose; quality; radiation; radiographs; radiologists; radiology; range; renal; resolution; resonance imaging; results; review; right; role; scan; size; spectrum; spinal; spine; spr; studies; study; surgery; syndrome; system; technique; time; tissue; treatment; tumor; ultrasound; university; use; value; vascular; venous; years cache: cord-014687-0am4l5ms.txt plain text: cord-014687-0am4l5ms.txt item: #17 of 196 id: cord-014875-xhzxhwgo author: None title: Book Reviews date: 2003 words: 7146 flesch: 44 summary: Having read a few of these type of books, the first thing that struck me about this book was the title. I strongly recommend this book to labs that are working on membrane transporter based drug delivery, design, and discovery. keywords: book; cell; chapters; delivery; dna; drug; field; gene; hplc; information; membrane; methods; polymers; section; technology; transporters cache: cord-014875-xhzxhwgo.txt plain text: cord-014875-xhzxhwgo.txt item: #18 of 196 id: cord-015334-8p124rwp author: None title: ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts date: 2008-06-11 words: 51170 flesch: 47 summary: The main off-label indications were prevention of hemorrhagic risk of antiplatelet agent (23%), hemoglobin decrease(16%), anticoagulant co-prescription(13%), steroids co-prescription(6%). A rinse volume of 10 ml improved significantly the transit of Mopral Ò , Ogast Ò and Ogastoro Ò (+4.8%, keywords: administration; age; analysis; background; blood; care; cases; community; conclusions; control; criteria; data; days; department; design; disease; dosage; dose; drug; effects; errors; group; guidelines; health; hospital; information; interventions; level; management; mean; measures; medical; medication; months; new; non; number; nurses; objective; oral; order; outcome; outcome measures; pain; patients; period; pharmaceutical; pharmacists; pharmacy; physicians; practice; prescriptions; problems; quality; questionnaire; recommendations; results; risk; safety; setting; studies; study; therapy; time; total; treatment; use; years cache: cord-015334-8p124rwp.txt plain text: cord-015334-8p124rwp.txt item: #19 of 196 id: cord-015684-q10sx1dm author: Cacabelos, Ramón title: Pharmacogenomic Biomarkers in Neuropsychiatry: The Path to Personalized Medicine in Mental Disorders date: 2009 words: 17012 flesch: 35 summary: 4th Edn Pharmacogenomics: the inherited basis for interindividual differences in drug response Pharmacogenetics and pharmacogenomics: development, science, and translation Pharmacogenomics and therapeutic prospect in dementia Pharmacogenetic basis for therapeutic optimization in Alzheimer's disease Infl uence of pharmacogenetic factors on Alzheimer's disease therapeutics Pharmacogenetic aspects of therapy with cholinesterase inhibitors: the role of CYP2D6 in Alzheimer's disease pharmacogenetics From pharmacogenetics and ecogenetics to pharmacogenomics Inheritance and drug response Pharmacogenomics-Drug disposition, drug targets, and side effects National estimates of medication use in nursing homes Medicare Current Benefi ciary Survey and the 1996 Medical Expenditure Survey Antidepressant drugs prescribing among elderly subjects: a population-based study Potentially inappropriate medication use among elderly home care patients in Europe Potentially inappropriate medication use by elderly persons in U.S. Health Maintenance Organizations The Metabolic & Molecular Bases of Inherited Disease Catalog of 680 variants among eight cytochrome P450 (CYP) genes: nine esterase genes, and two other genes in the Japanese population DNA sequence variations in a 3.7-kb noncoding sequence 5-prime of the CYP1A2 gene: implications for human population history and natural selection PM frequencies of major CYPs in Asians and Caucasians Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population CYP2C9 allelic variants: ethnic distribution and functional signifi cance Identifi cation and functional characterization of a new CYP2C9 variant (CYP2C9 * 5 1 ) expressed among African Americans Molecular basis of ethnic differences in drug disposition and response Isolation, sequence and genotyping of the drug metabolizer CYP2D6 gene in the Colombian population Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes Cytochrome P450 in the brain: a review The expression of CYP2B6, CYP2C9 and CYP2A4 genes: a tangle of networks of nuclear and steroid receptors Regulation of cytochrome P450 (CYP) genes by nuclear receptors The CYP2C19 enzyme polymorphism Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences Clinically signifi cant drug interactions with cholinesterase inhibitors: a guide for neurologists Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population Ten percent of North Spanish individuals carry duplicated or triplicated CYP2D6 genes associated with ultrarapid metabolism of debrisoquine Clinical pharmacokinetics of galantamine Impact of the CYP2D6 polymorphism on steady-state plasma concentrations and clinical outcome of donepezil in Alzheimer's disease patients Molecular pathology and pharmacogenomics in Alzheimer's disease: polygenic-related effects of multifactorial treatments on cognition, anxiety, and depression Pharmacogenomic studies with a combination therapy in Alzheimer's disease Interethnic differences in genetic polymorphisms of CYP2D6 in the U.S. population: clinical implications Donepezil use in Alzheimer disease Effects of cholinergic markers in rat brain and blood after short and prolonged administration of donepezil Treatment with MPEP and MTEP can induce gene expression related to ATP synthesis, hydrolase activity, and signaling pathways associated with mitogen-activated protein kinase (MAPK) in the frontal cortex, this constituting another potential therapeutic target in some neuropsychiatric disorders. keywords: activity; alzheimer; apoe; brain; carriers; cns; cyp2d6; dementia; disease; disorders; drug; enzymes; expression; factors; genes; genotype; infl; levels; metabolism; patients; pharmacogenomics; pms; profi; receptor; response; schizophrenia; studies; treatment; ums; variants cache: cord-015684-q10sx1dm.txt plain text: cord-015684-q10sx1dm.txt item: #20 of 196 id: cord-016283-b6yywn9f author: Hasan, Ashfaq title: Clinical Aspects and Principles of Management of Tuberculosis date: 2019-08-07 words: 6934 flesch: 41 summary: Disseminated TB Disseminated TB should always raise suspicion for an accompanying immune deficiency such as HIV disease. In a recent study done on TB patients requiring ICU admission, mortality was 72.5% (Tatar et al. 2018 ). keywords: agents; children; diagnosis; disease; drug; hiv; mdr; patients; resistance; rifampicin; therapy; treatment; tuberculosis cache: cord-016283-b6yywn9f.txt plain text: cord-016283-b6yywn9f.txt item: #21 of 196 id: cord-016309-6mw8okmt author: Bule, Mohammed title: Antivirals: Past, Present and Future date: 2019-06-06 words: 8230 flesch: 27 summary: Therefore, the major concern in antiviral drug development is the identification of specific targets with increased selectivity and reduced side effects, which limit the therapeutic use of antiviral drugs in comparison to antibacterial agents (Dal Pozzo and Thiry 2014) . Antiviral drugs not just penetrate to disrupt the virus’ cellular divisions but also have a negative impact on normal physiological pathways in the host. keywords: activity; acyclovir; agents; antiviral; cats; compounds; diseases; dna; drug; et al; feline; herpes; infection; replication; rna; treatment; virus; viruses; vitro cache: cord-016309-6mw8okmt.txt plain text: cord-016309-6mw8okmt.txt item: #22 of 196 id: cord-016460-39yniw0t author: Ben-Chetrit, Eldad title: Colchicine date: 2018-07-31 words: 9583 flesch: 39 summary: The pharmacologic basis of treatment with colchicine in children with familial Mediterranean fever Mechanism of the anti-inflammatory effect of colchicine in rheumatic diseases: a possible new outlook through microarray analysis Gout-associated uric acid crystals activate the NALP3 inflammasome Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: a rationale for use of low-dose colchicine Innate immune sensing of bacterial modifications of Rho GTPases by the pyrin inflammasome Interaction of pyrin with 14.3.3 in an isoform-specific and phosphorylation-dependent manner regulates its translocation to the nucleus Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS Technical advance: inhibition of neutrophil chemotaxis by colchicine is modulated through viscoelastic properties of subcellular compartments Colchicine attenuates renal injury in a model of hypertensive chronic kidney disease Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells The effects of colchicine on the progression and regression of encapsulating peritoneal sclerosis Colchicine use in children and adolescents with familial Mediterranean fever: literature review and consensus statement Colchicine is a safe drug in children with familial Mediterranean fever Current trends in colchicine treatment in familial Mediterranean fever Colchicine intoxication clinical pharmacology, risk factors, features and management Colchicine: old and new Estimation of colchicine in a poisoned patient by using high performance liquid chromatography Treatment of severe colchicine overdose with colchicine specific fab fragments Vos FR high flux dialysis membranes improve lipid profile in chronic hemodialysis patients Colchicine clearance by high-flux polysulfone dialyzers ABC drug transporters as molecular targets for the prevention of multidrug resistance and drug-drug interactions Colchicine myotoxicity: case reports and literature review Colchicine use in cyclosporine treated transplant recipients: how little is too much? MDR-and CYP3A4-mediated drug-drug interactions Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4 Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions Acute myopathy in a patient with concomitant use of pravastatin and colchicine Fatal interaction between clarithromycin and colchicine in patients with renal insufficiency: a retrospective study Cytoskeletal myotoxicity from simvastatin and colchicine Rhabdomyolysis in a patient treated with colchicine and atorvastin Possible colchicine rhabdomyolysis in a fluvastatin-treated patient Novel evidence-based colchicine dosereduction algorithm to predict and prevent colchicine toxicity in the presence of cytochrome P450 Effect of colchicine on guinea pig intrinsic factor-vitamin B12 receptor Colchicineinduced lactose malabsorption in patients with familial Mediterranean fever Azoospermia caused by colchicine-a case report The effect of colchicine on the spermatogenesis of rabbits A cytogenetic evaluation of long term colchicines therapy in the treatment of familial Mediterranean fever (FMF) Testicular function in patients with familial Mediterranean fever, long-term colchicine treatment Fertility and obstetric history in patients with familial Mediterranean fever on long term colchicine therapy The effect of colchicine on human spermatozoal motility in vitro Colchicine and testicular function in man Urological evaluation of Behçet patients and the effect of colchicine on fertility Azoospermia in FMF patients-the role of colchicine and amyloidosis Daily prophylactic colchicines in familial Mediterranean fever The effect of FMF and colchicine on pregnancies outcome of wives of patients with FMF Familial Mediterranean fever and menstruation Effects of hormone therapy on inflammatory cell adhesion molecules in postmenopausal healthy women Qualitative study of the interaction mechanism of estrogenic drugs with tubulin Safety of colchicine therapy during pregnancy Familial Mediterranean fever and its implications for fertility and pregnancy Colchicine treatment in conception and pregnancy: two hundred and thirty one pregnancies in patients with familial Mediterranean fever Pregnancy outcome after in utero exposure to colchicine Outcome of pregnancies in FMF women with colchicine Breast feeding during colchicine therapy for familial Mediterranean fever Colchicine in breast-milk of patients with FMF Colchicine treatment in familial Mediterranean fever (FMF)-reappraisal after 15 years Colchicine therapy of children with FMF (abstract) Growth and IGF-1 levels of children with familial Mediterranean fever on colchicine treatment EULAR recommendations for the management of familial Mediterranean fever Familial Mediterranean fever is no longer a rare disease in Japan Evidencebased recommendations for the practical management of familial Mediterranean fever Comparison of the efficacy of once-and twice-daily colchicine dosage in pediatric patients with familial Mediterranean fever-a randomized controlled non-inferiority trial High versus low dosing of oral colchicine for early acute gout flare: twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine study American College of Rheumatology guidelines for management of gout. When abdominal cramps persist, lowering colchicine dose may be effective. keywords: acute; cells; colchicine; disease; dose; drug; effect; fever; fmf; gout; liver; mediterranean; microtubules; patients; pyrin; study; therapy; treatment; tubulin cache: cord-016460-39yniw0t.txt plain text: cord-016460-39yniw0t.txt item: #23 of 196 id: cord-017062-dkw2sugl author: Singh, Indu title: Delivery Systems for Lymphatic Targeting date: 2013-10-08 words: 9780 flesch: 31 summary: Colloidal materials, for example, liposomes, activated carbon particles, emulsions, lipids and polymeric particulates, are highly taken up by the lymphatics; that's why nowadays these substances are emerging as potential carriers for lymphatic drug targeting [ 29 ] . Nanocapsules coated with hydrophobic polymers could be easily captured by lymphatic cells in the body, when administered, because the hydrophobic particle is generally recognised as a foreign substance. keywords: administration; cancer; carriers; cells; delivery; drug; injection; liposomes; lymph nodes; lymphatic; nodes; particles; site; system; targeting; treatment; tumour; uptake; vessels cache: cord-017062-dkw2sugl.txt plain text: cord-017062-dkw2sugl.txt item: #24 of 196 id: cord-017583-72mbsib7 author: Devarajan, Padma V. title: Infectious Diseases: Need for Targeted Drug Delivery date: 2014-09-01 words: 8881 flesch: 22 summary: The chapter thus provides an overview on important aspects of infectious diseases and the challenges therein, while stressing on the promise of targeted drug delivery in augmenting therapy of infectious diseases. of the microorganism. Targeted drug delivery for the therapy of veterinary infections assumes immense importance not only for improved animal health but due to the challenges posed by zoonotic diseases. keywords: cells; delivery; diseases; drug; endocytosis; infections; infl; intracellular; lipid; liposomes; macrophages; mechanisms; membrane; mycobacterium; nanocarriers; nanoparticles; phagocytosis; receptors; resistance; role; specifi; surface; targeting; treatment; tuberculosis; uptake cache: cord-017583-72mbsib7.txt plain text: cord-017583-72mbsib7.txt item: #25 of 196 id: cord-017702-v46ye328 author: Ganguly, Nirmal Kumar title: Pharmacogenomics and Personalized Medicine for Infectious Diseases date: 2013-06-11 words: 16571 flesch: 34 summary: From the several RNAi screenings in human and in fruit fl y cells, only 300 host factors were validated from about 10,000 and 20,000 targets identifi ed in the initial screen (Agaisse et al. 2005 ; Brass et al. 2008 ; Konig et al. 2008 ; Krishnan et al. 2008 ; Zhou et al. 2008 ) . It has been observed in the case of measles vaccination that only 10 % of the population was seronegative and clustered in family (Poland 1999a , b ; Poland et al. 1999c ). keywords: acetylators; activity; discovery; disease; drug; enzymes; et al; gene; genome; hepatotoxicity; hla; host; human; infection; isoniazid; leishmaniasis; major; malaria; nat2; pathogen; patients; polymorphism; population; protein; resistance; response; risk; slow; studies; study; susceptibility; technologies; treatment; tuberculosis cache: cord-017702-v46ye328.txt plain text: cord-017702-v46ye328.txt item: #26 of 196 id: cord-018595-x3tleomb author: Dodiuk-Gad, Roni P. title: Adverse Medication Reactions date: 2017-04-25 words: 16329 flesch: 37 summary: In view of the large diversity of cutaneous drug reactions, it is helpful to approach them as clinicopathologic entities and to base the diagnosis on a combination of clinical, histo- logical and disease course data [89] . Heightened awareness of the possible mimicry of other skin diseases and of the suspicious histopathological clues pointing to drug etiology are key elements to the appropriate histological diagnosis of drug reactions in the skin [85, 88, 89] . keywords: acute; adrs; carbamazepine; cases; cells; diagnosis; dress; drug; drug hypersensitivity; drug reactions; epidermal; eruption; hla; hypersensitivity; involvement; johnson; lesions; necrolysis; patients; reactions; sjs; skin; specific; stevens; study; symptoms; syndrome; treatment; type; urticaria cache: cord-018595-x3tleomb.txt plain text: cord-018595-x3tleomb.txt item: #27 of 196 id: cord-018714-i291z2ju author: Criado, Paulo Ricardo title: Adverse Drug Reactions date: 2016-12-31 words: 23933 flesch: 36 summary: This group of drug reactions includes anaphylaxis, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and, depending on the systemic involvement, erythroderma. This group of drug reactions includes anaphylaxis, SJS, TEN, drug hypersensitivity, and, depending on the systemic involvement, erythroderma, acute generalized exanthematous pustulosis (AGEP), cutaneous necrosis induced by anticoagulants, druginduced vasculitis, and reactions such as serum disease [4] . keywords: acute; agents; cases; cells; chemotherapeutic; chemotherapy; corticosteroids; days; diagnosis; dihs; disease; dress; drug; drug reactions; eccrine; edema; epidermal; eruption; erythema; fig; hla; immune; involvement; lesions; necrosis; onset; patients; reactions; reactivation; sjs; skin; symptoms; syndrome; treatment; type; use; vasculitis; weeks cache: cord-018714-i291z2ju.txt plain text: cord-018714-i291z2ju.txt item: #28 of 196 id: cord-020766-0gacqii4 author: Murthy, Sreekant title: Nanotechnology: Towards the detection and treatment of inflammatory diseases date: 2006 words: 7185 flesch: 32 summary: Biological nanostructures used in drug delivery systems include lipid-, silica-, polymer-, fullerene (carbonbased buckyballs, bucky tubes)-based nanostructures such as liposomes, micelles and nanoparticle systems. Liposomes have been widely used as drug delivery systems, but current knowledge extends the use of any nanoparticle as an efficient carrier with necessary modifications. keywords: agents; cancer; cells; delivery; detection; drug; imaging; inflammation; liposomal; liposomes; molecules; nanoparticles; nanotubes; properties; qds; size; systems cache: cord-020766-0gacqii4.txt plain text: cord-020766-0gacqii4.txt item: #29 of 196 id: cord-022082-1dq623oe author: Greaves, Peter title: Respiratory Tract date: 2007-09-28 words: 19712 flesch: 22 summary: ^^^ Plasticembedded sections also show the inclusions in other pulmonary cells including pneumocytes attached to the alveolar walls, from which they can be seen discharging into the alveolar spaces. In contrast to findings in people, squamous cell lung tumours are only occasionally seen arising spontaneously in laboratory animals. keywords: administration; agents; airways; alveolar; animals; bronchial; cells; changes; drug; effects; epithelium; fibrosis; humans; hyperplasia; inhalation; laboratory; laboratory animals; lesions; lung; macrophages; mice; mucosa; nasal; olfactory; pulmonary; rats; respiratory; species; studies; study; tissue; toxicity; tract; type cache: cord-022082-1dq623oe.txt plain text: cord-022082-1dq623oe.txt item: #30 of 196 id: cord-023509-tvqpv6fp author: Corrin, Bryan title: Occupational, environmental and iatrogenic lung disease date: 2011-03-02 words: 42595 flesch: 39 summary: Aluminium powder holds a paradoxical position in regard to lung disease. 366 More directly, welders may be exposed to asbestos insulation that they themselves use, while welders of special steel alloys run the risk of metal-induced asthma, metal fume fever, polymer fume fever and the consequences of toxic metal fume inhalation, 367 all of which are described separately in this chapter, as is lung disease in aluminium welders. keywords: acute; air; aluminium; alveolar; analysis; asbestos; asbestos exposure; asbestos fibres; asthma; beryllium; blood; bodies; bronchiolitis; cases; cause; cells; changes; chronic; coal; damage; diffuse; drug; dust; dust exposure; dust pneumoconiosis; effects; electron; emphysema; evidence; exposure; factor; fibres; fibrosis; fig; gas; interstitial; lesions; lung; lung cancer; lung disease; lung injury; lung tissue; macrophages; mineral; non; occupational; oedema; oxygen; particles; patients; pneumoconiosis; pneumonia; pulmonary; risk; silica; silicosis; smoking; study; syndrome; tissue; toxicity; type; water; workers cache: cord-023509-tvqpv6fp.txt plain text: cord-023509-tvqpv6fp.txt item: #31 of 196 id: cord-024833-e6vcf4un author: None title: Forum date: 2019-12-19 words: 8121 flesch: 44 summary: A new requirement of the Cures Act was for the FDA to make its best practices for drug safety surveillance publicly available on the web. The FDA has now announced the availability of a draft document entitled Best Practices in Drug and Biological Product Postmarket Safety Surveillance for FDA Staff, which outlines the agency's approach to timely postmarketing analyses of drugs and biologics, and includes a high-level overview of tools, methods, and signal detection and evaluation activities, using varied data sources, for drug safety surveillance to provide a broader context and a general overview of our overarching effort and commitment in this area, says Woodcock. keywords: age; authors; cases; data; drug; events; fda; health; healthcare; new; patients; products; reporting; reports; risk; safety; signals; study; use; vaccine; years cache: cord-024833-e6vcf4un.txt plain text: cord-024833-e6vcf4un.txt item: #32 of 196 id: cord-032561-x3qbqy69 author: Liu, Gengqi title: Stimulus-Responsive Nanomedicines for Disease Diagnosis and Treatment date: 2020-09-02 words: 25271 flesch: 43 summary: In the microenvironment of the diseased sites, the levels of some enzymes can be abnormal; therefore, enzyme-responsive systems represent an appealing strategy for the development of responsive drug carriers. In the microenvironment of the diseased sites, the levels of some enzymes can be abnormal; therefore, enzyme-responsive systems represent an appealing strategy for the development of responsive drug carriers. keywords: addition; bond; cancer; cells; delivery; design; disulfide; drug; drug delivery; drug release; enzyme; ester; group; gsh; imaging; light; nanoparticles; nir; redox; release; self; stimuli; stimulus; systems; therapy; tissues; treatment; tumor; ultrasound cache: cord-032561-x3qbqy69.txt plain text: cord-032561-x3qbqy69.txt item: #33 of 196 id: cord-033723-jy5fdsp9 author: Orhobor, Oghenejokpeme I. title: Generating Explainable and Effective Data Descriptors Using Relational Learning: Application to Cancer Biology date: 2020-09-19 words: 4016 flesch: 47 summary: One can think of the Boolean molecular fingerprint and RL representations of the drugs in the stated problem as views in multi-view learning, as both of these representations offer different perspectives in what constitutes the known properties of a drug. In this paper we report the use of RL representations to enhance the predictive accuracy of traditional propositional data representations for a relevant problem in cancer biology. keywords: data; descriptors; drug; knowledge; learning; performance; representations cache: cord-033723-jy5fdsp9.txt plain text: cord-033723-jy5fdsp9.txt item: #34 of 196 id: cord-034406-i1hbx3pz author: Matthews, Abigail A. title: Developing inhaled protein therapeutics for lung diseases date: 2020-10-30 words: 8744 flesch: 37 summary: As only one medicine Respimat uses SMI, its suitability for protein drug delivery is not clear. It is probable that HYDRA nebulisers may be developed for pulmonary protein drug delivery. keywords: aerosol; aggregation; delivery; diseases; drug; excipients; formulation; inhalation; insulin; lung; nebulisers; particles; protein; stability; studies; therapeutics; use cache: cord-034406-i1hbx3pz.txt plain text: cord-034406-i1hbx3pz.txt item: #35 of 196 id: cord-035236-7rfc73qb author: Karabasz, Alicja title: Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature date: 2020-11-06 words: 10773 flesch: 22 summary: The purpose of this work is to present the latest scientific reports on polymeric nanocarriers for medical applications. A literature search (PubMED) revealed that polymeric nanocarriers are most often used as drug delivery systems. keywords: acid; activity; antigen; cancer; cells; core; delivery; drug; imaging; layer; method; nanocapsules; nanocarriers; nanomaterials; nanoparticles; phase; polymeric; release; shell; studies; systems; targeting; therapy; treatment; tumor; vivo cache: cord-035236-7rfc73qb.txt plain text: cord-035236-7rfc73qb.txt item: #36 of 196 id: cord-102823-zult69f2 author: Nguyen, Thin title: GraphDTA: Predicting drug–target binding affinity with graph neural networks date: 2020-10-02 words: 4966 flesch: 53 summary: New drugs cost US $2.6 billion to develop Drug repositioning: identifying and developing new uses for existing drugs Pharmacogenetics in drug discovery and development: a translational perspective Overcoming drug development bottlenecks with repurposing: old drugs learn new tricks A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Large-scale comparison of machine learning methods for drug target prediction on ChEMBL Graph convolutional neural networks for predicting drug-target interactions Chemi-Net: A molecular graph convolutional network for accurate drug property prediction Convolutional neural network based on SMILES representation of compounds for detecting chemical motif Molecular graph convolutions: moving beyond fingerprints Graph convolutional networks for computational drug development and discovery Large-scale learnable graph convolutional networks Interpretable drug target prediction using deep neural representation SMILES, a chemical language and information system. keywords: affinity; drug; gcn; graph; layer; model; neural; prediction; protein; target cache: cord-102823-zult69f2.txt plain text: cord-102823-zult69f2.txt item: #37 of 196 id: cord-103876-2rg2qtdq author: Watkins, Laura C. title: Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics date: 2020-06-20 words: 5532 flesch: 40 summary: World Health Organization The M2 proton channels of influenza A and B viruses Selective proton permeability and pH regulation of the influenza virus M2 channel expressed in mouse erythroleukaemia cells Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block Viroporins: structure, function and potential as antiviral targets SARS coronavirus E protein forms cation-selective ion channels Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue Histidines, heart of the hydrogen ion channel from influenza A virus: toward an understanding of conductance and proton selectivity Structure and mechanism of the M2 proton channel of influenza A virus Mechanisms of proton conduction and gating in influenza M2 proton channels from solid-state NMR Effect of cytosolic pH on inward currents reveals structural characteristics of the proton transport cycle in the influenza A protein M2 in cell-free membrane patches of Xenopus oocytes Acid activation mechanism of the influenza A M2 proton channel Put a cork in it: Plugging the M2 viral ion channel to sink influenza In Vitro Pharmacokinetic Optimizations of AM2-S31N Channel Blockers Led to the Discovery of Slow-Binding Inhibitors with Potent Antiviral Activity against Drug-Resistant Influenza A Viruses Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus Identification of hits as matrix-2 protein inhibitors through the focused screening of a small primary amine library Interpreting Thermodynamic Profiles of Aminoadamantane Compounds Inhibiting the M2 Proton Channel of Influenza A by Free Energy Calculations Hydrogen-bonded water molecules in the M2 channel of the influenza A virus guide the binding preferences of ammonium-based inhibitors Computationally Efficient Multiconfigurational Reactive Molecular Dynamics Computationally Efficient Multiscale Reactive Molecular Dynamics to Describe Amino Acid Deprotonation in Proteins Understanding the essential proton-pumping kinetic gates and decoupling mutations in cytochrome c oxidase Proton movement and coupling in the POT family of peptide transporters Modulating the Chemical Transport Properties of a Transmembrane Antiporter via Alternative Anion Flux Exchange Pathways in ClC-ec1 Antiporter Proton-Induced Conformational and Hydration Dynamics in the Influenza A M2 Channel High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction Computational studies to date have primarily focused on the means of entry into the channel and location of binding, 42-46 but have not deduced specific interactions between the drug, channel, and channel water involved in binding as they relate specifically to similar interactions seen in the PT mechanism. keywords: binding; channel; drug; excess; hydrogen; influenza; protein; proton; water cache: cord-103876-2rg2qtdq.txt plain text: cord-103876-2rg2qtdq.txt item: #38 of 196 id: cord-104431-3rblzyry author: Hill, Andrew title: Minimum costs to manufacture new treatments for COVID-19 date: 2020-04-30 words: 5534 flesch: 54 summary: For consistency, we selected a single data source per country to be used for all searches of drug prices within that country, based on the organisation of data and perceived reliability. The minimum costs of drug production can be estimated by calculating the cost of active pharmaceutical ingredients (aPi), which is combined with costs of excipients, formulation, packaging and a profit margin, to estimate the price of 'final finished product' (FFP) -the drug ready for use. keywords: api; cost; countries; course; covid-19; day; drugs; list; prices; production; treatment; trials cache: cord-104431-3rblzyry.txt plain text: cord-104431-3rblzyry.txt item: #39 of 196 id: cord-104493-yqf7tyo4 author: Keshmiri Neghab, Hoda title: Nanoformulation-Based Antiviral Combination Therapy for Treatment of COVID-19 date: 2020 words: 1015 flesch: 27 summary: A new trick for an old drug? A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury Recent developments of nanotherapeutics for targeted and long-acting, combination HIV chemotherapy A genosensor for detection of HTLV-I based on photoluminescence quenching of fluorescent carbon dots in presence of iron magnetic nanoparticle-capped Carbon nanotubebased nanocarrier loaded with ribavirin against grass carp reovirus Nanomaterials designed for antiviral drug delivery transport across biological barriers Progress in nanomedicine: approved and investigational nanodrugs Lazartigues E. Species-specific inhibitor sensitivity of angiotensin-converting enzyme 2 (ACE2) and its implication for ACE2 activity assays Biodegradable PLGAb-PEG polymeric nanoparticles: synthesis, properties, and nanomedical applications as drug delivery system 3. Department of Medical Laser The formidable barriers for gastrointestinal tract, skin and cell have limited the therapeutic effects of antiviral drugs. keywords: coronavirus; drug; enzyme; ribavirin cache: cord-104493-yqf7tyo4.txt plain text: cord-104493-yqf7tyo4.txt item: #40 of 196 id: cord-130351-w9mij6c6 author: Mamidala, Estari title: In silico identification of clinically approved medicines against the main protease of SARS-CoV-2, causative agent of covid-19 date: 2020-04-25 words: 2683 flesch: 44 summary: Among the 47 approved drugs, 2 drugs are anti-H1N1 drugs, 4 are anti-TB drugs, 24 are anti-HIV-1 drugs and 17 are anti-malarial drugs are selected from PubChem database. Docking studies revealed that drug Oseltamivir (anti-H1N1 drug), Rifampin (anti-TB drug), Maraviroc, Etravirine, Indinavir, Rilpivirine (anti-HIV drugs) and Atovaquone, Quinidine, Halofantrine, Amodiaquine, Tetracylcine, Azithromycin, hydroxycholoroquine (anti-malarial drugs) among others binds in the active site of the protease with similar or higher affinity. keywords: anti; cov-2; covid-19; docking; drugs; protease; sars cache: cord-130351-w9mij6c6.txt plain text: cord-130351-w9mij6c6.txt item: #41 of 196 id: cord-178783-894gkrsk author: Zhang, Rui title: Drug Repurposing for COVID-19 via Knowledge Graph Completion date: 2020-10-19 words: 8191 flesch: 39 summary: The potential of recent advances in artificial intelligence (AI) and machine learning for COVID-19 drug repurposing has also been highlighted [14] and several studies using these techniques have reported promising results [15] [16] [20, 21] ap-proach for COVID-19 drug repurposing. keywords: approach; completion; covid-19; data; discovery; drug; graph; inhibits; knowledge; literature; methods; models; network; patterns; protein; relations; repurposing cache: cord-178783-894gkrsk.txt plain text: cord-178783-894gkrsk.txt item: #42 of 196 id: cord-199630-2lmwnfda author: Ray, Sumanta title: Predicting potential drug targets and repurposable drugs for COVID-19 via a deep generative model for graphs date: 2020-07-05 words: 6402 flesch: 45 summary: After the model is trained the drug-CoV-host links are predicted using the following equation: where A i j represents the possible links between all combination of SARS-CoV-2 nodes and drug nodes. To develop suitable therapeutic strategies and design antiviral drugs, a comprehensive understanding of the interactions between viral and human proteins is essential 2 . keywords: cov-2; drugs; graph; host; human; interaction; links; matrix; model; network; nodes; proteins; sars; virus cache: cord-199630-2lmwnfda.txt plain text: cord-199630-2lmwnfda.txt item: #43 of 196 id: cord-203191-7ftg6bfx author: Guo, Kai title: Identification of Repurposal Drugs and Adverse Drug Reactions for Various Courses of Coronavirus Disease 2019 (COVID-19) Based on Single-cell RNA Sequencing Data date: 2020-05-16 words: 3736 flesch: 39 summary: The drug connectivity score (CS) with a negative value smaller than -90 was used to determine candidate drugs and compounds. Connecting to the LINCS database of small-molecule perturbations on gene expression, we identified candidate drugs and compounds that can reverse these upregulated and downregulated genes via the CLUE platform. keywords: cell; coronavirus; covid-19; data; disease; drugs; inhibitor; patients; potential; sars cache: cord-203191-7ftg6bfx.txt plain text: cord-203191-7ftg6bfx.txt item: #44 of 196 id: cord-203232-1nnqx1g9 author: Canturk, Semih title: Machine-Learning Driven Drug Repurposing for COVID-19 date: 2020-06-25 words: 5028 flesch: 49 summary: Using the National Center for Biotechnology Information virus protein database and the DrugVirus database, which provides a comprehensive report of broad-spectrum antiviral agents (BSAAs) and viruses they inhibit, we trained ANN models with virus protein sequences as inputs and antiviral agents deemed safe-in-humans as outputs. This undermined our assumption that drug trials are hierarchical; though, in reality this is usually the case. keywords: acid; amino; antivirals; cov-2; database; dataset; drug; models; sars; sequences; virus cache: cord-203232-1nnqx1g9.txt plain text: cord-203232-1nnqx1g9.txt item: #45 of 196 id: cord-214795-8jweuq50 author: Mongia, Aanchal title: DeepVir -- Graphical Deep Matrix Factorization for"In Silico"Antiviral Repositioning: Application to COVID-19 date: 2020-09-22 words: 6435 flesch: 41 summary: Similar behavior appears when using the genomic similarity (S1 v ) for viruses and varying the kind of drug similarity used (columns 1 and 4 of Table 5 ). Hence, the drug similarity matrix (of size 86 × 86) and virus similarity matrix (of size 23 × 23) are fixed and encode the metadata available. keywords: association; completion; disease; drug; factorization; graph; matrix; matrix completion; prediction; problem; similarity; viruses cache: cord-214795-8jweuq50.txt plain text: cord-214795-8jweuq50.txt item: #46 of 196 id: cord-232446-vvb2ffhv author: Mongia, Aanchal title: A computational approach to aid clinicians in selecting anti-viral drugs for COVID-19 trials date: 2020-07-03 words: 7129 flesch: 43 summary: The drug-virus associations and the similarity information are assembled as three matrices: drug-virus association matrix (Y ), drug similarity matrix (S d ) and virus similarity matrix (S v ). We also demonstrate how the selected drugs change as the SARS-Cov-2 mutates over time, suggesting the importance of such a tool in drug prediction. keywords: association; completion; covid-19; database; drugs; graph; information; matrix; matrix completion; methods; prediction; similarity; techniques; virus; viruses cache: cord-232446-vvb2ffhv.txt plain text: cord-232446-vvb2ffhv.txt item: #47 of 196 id: cord-252147-bvtchcbt author: Domingo-Espín, Joan title: Engineered Biological Entities for Drug Delivery and Gene Therapy: Protein Nanoparticles date: 2011-11-15 words: 17227 flesch: 30 summary: The main biological production systems for protein drugs are described below. Finally, some successful examples of protein nanoparticles on the market will be described in addition to protein products currently in clinical trials and under preclinical research in order to envision which type of protein nanoparticles will be available soon on the market. keywords: binding; cancer; cell; complex; delivery; design; dna; drug; drug delivery; expression; gene; gene delivery; human; interactions; molecules; nanoparticles; nuclear; particles; peptides; production; properties; protein; receptor; self; specific; system; targeting; therapy; transfer; tumor; use; vector; virus; vivo; vlps cache: cord-252147-bvtchcbt.txt plain text: cord-252147-bvtchcbt.txt item: #48 of 196 id: cord-252166-qah877pk author: Ekins, S title: In silico pharmacology for drug discovery: applications to targets and beyond date: 2007-09-01 words: 12716 flesch: 32 summary: However, such pharmacological targets have been difficult for in silico methods to derive small molecule inhibitors owing to generally quite shallow binding sites. For example, the work of Fliri et al. (2005b) presented the biological spectra for a cross-section of the proteome. keywords: activity; binding; compounds; database; design; discovery; drug; et al; human; inhibitors; methods; models; molecular; molecules; novel; pharmacology; pharmacophore; protein; qsar; receptor; screening; set; silico; structure; targets cache: cord-252166-qah877pk.txt plain text: cord-252166-qah877pk.txt item: #49 of 196 id: cord-253115-ekgdsv4f author: Mehta, Meenu title: Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases date: 2019-08-01 words: 7331 flesch: 32 summary: III: effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro Respiratory syncytial virus infection in Fischer 344 rats is attenuated by short interfering RNA against the RSV-NS1 gene Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration Chitosan Related Compositions and Methods for Delivery of Nucleic Acids and Oligonucleotides into a Cell Nasal delivery of chitosan-DNA plasmid expressing epitopes of respiratory syncytial virus (RSV) induces protective CTL responses in BALB/c mice Intranasal IFNgamma gene transfer protects BALB/c mice against respiratory syncytial virus infection Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency Dendritic cell targeted chitosan nanoparticles for nasal DNA immunization against SARS CoV nucleocapsid protein Biodegradable polymeric nanocarriers for pulmonary drug delivery Poly(lactic acid)-poly(ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA Design and gene delivery activity of modified polyethylenimines Characterization of commercially available and synthesized polyethylenimines for gene delivery PLGA-PEI nanoparticles for gene delivery to pulmonary epithelium Poly(amidoamine) dendrimer nanocarriers and their aerosol formulations for siRNA delivery to the lung epithelium Application of dendrimers for the treatment of infectious diseases Dendrimer nanocarriers for transport modulation across models of the pulmonary epithelium Synthesis and influenza virus inhibitory activities of carbosilane dendrimers peripherally functionalized with hemagglutinin-binding Peptide Dendrimer-inspired nanomaterials for the in vivo delivery of siRNA to lung vasculature Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases In vitro/in vivo investigation on the potential of Pluronic(R) mixed micelles for pulmonary drug delivery Microencapsulated chitosan nanoparticles for lung protein delivery Sustained delivery by leucinemodified chitosan spray-dried respirable powders Attenuation of fibrosis in vitro and in vivo with SPARC siRNA Self-assembled micelle interfering RNA for effective and safe targeting of dysregulated genes in pulmonary fibrosis Characterization of polymeric micelles for pulmonary delivery of beclomethasone dipropionate Use of oligonucleotide microarrays for rapid detection and serotyping of acute respiratory disease-associated adenoviruses Use of an oligonucleotide array for laboratory diagnosis of bacteria responsible for acute upper respiratory infections A review of antisense therapeutic interventions for molecular biological targets in asthma Silencing of microRNAs in vivo with antagomirs Cellular uptake and intracellular trafficking of oligonucleotides Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial Infusion-related and hypersensitivity reactions of monoclonal antibodies used to treat colorectal cancer-identification, prevention, and management A randomised, open-label, parallel group phase 2 study of antisense oligonucleotide therapy in acromegaly An overview of the clinical application of antisense oligonucleotides for RNA-targeting therapies FDA-approved oligonucleotide therapies in 2017 Antisense technologies. Particles with 1-100 nm size range are termed as nanoparticles which have been newly employed in targeted drug delivery [38] . keywords: antisense; cancer; cells; chitosan; delivery; diseases; dna; drug; gene; liposomes; lung; nanoparticles; oligonucleotides; potential; sirna; targeting; therapy; treatment cache: cord-253115-ekgdsv4f.txt plain text: cord-253115-ekgdsv4f.txt item: #50 of 196 id: cord-255460-r5p5helx author: Aggarwal, Sadhna title: Drug repurposing for breast cancer therapy: Old weapon for new battle date: 2019-09-21 words: 7359 flesch: 38 summary: The widely used SERMs that have been repositioned as breast cancer drugs are tamoxifen (1977), toremifene (1997) and raloxifene (2007) . Drug companies that expand the repositioning in similar therapeutic areas, such as reusing ovarian cancer drug as breast cancer drug, had success rate of 67% in comparison to 33% success rate when explored in different area keywords: breast; breast cancer; cancer; combination; development; drug; effects; hormone; new; patients; phase; receptor; repositioning; repurposing; therapy; treatment; trial; women cache: cord-255460-r5p5helx.txt plain text: cord-255460-r5p5helx.txt item: #51 of 196 id: cord-255895-6at9gelt author: Han, Namshik title: Identification of SARS-CoV-2 induced pathways reveal drug repurposing strategies date: 2020-08-25 words: 4746 flesch: 43 summary: Our data-driven unsupervised approach and biological validation has uncovered 160 approved drugs not currently in clinical trials, which can be investigated immediately for repurposing and two drugs that show promise as anti-viral drugs. We constructed a SARS-CoV-2-induced protein (SIP) network, based on disease signatures defined by COVID-19 multi-omic datasets(Bojkova et al., 2020; Gordon et al., 2020), and cross-examined these pathways against approved drugs. keywords: analysis; covid-19; drugs; figure; infection; network; pathways; proteins; replication; sars; sip; sulfasalazine cache: cord-255895-6at9gelt.txt plain text: cord-255895-6at9gelt.txt item: #52 of 196 id: cord-256118-gxhhwqdd author: Abadie, R. title: “Caballo”: risk environments, drug sharing and the emergence of a hepatitis C virus epidemic among people who inject drugs in Puerto Rico date: 2020-10-23 words: 7858 flesch: 49 summary: key: cord-256118-gxhhwqdd authors: Abadie, R.; Dombrowski, K. title: “Caballo”: risk environments, drug sharing and the emergence of a hepatitis C virus epidemic among people who inject drugs in Puerto Rico date: 2020-10-23 journal: Harm Reduct J DOI: 10.1186/s12954-020-00421-z sha: doc_id: 256118 cord_uid: gxhhwqdd BACKGROUND: We explored partners’ motivation to engage in drug sharing, as well as its social organization, social roles and existing norms. keywords: caballo; drug; hcv; injection; participants; partners; puerto; pwid; rico; risk; sharing; study; syringe; users cache: cord-256118-gxhhwqdd.txt plain text: cord-256118-gxhhwqdd.txt item: #53 of 196 id: cord-256852-lrz17bdx author: Nayyar, Gaurvika M. L. title: Responding to the Pandemic of Falsified Medicines date: 2015-06-03 words: 4209 flesch: 31 summary: Few functional national regulatory authorities exist in low-income nations that lack trained staff and suitably equipped laboratories to test drug quality centrally or in peripheral pharmacies or markets. The focus of all actions tied to drug quality must be on public and individual health, and strengthening national capacities to improve the health of their citizens. keywords: convention; counterfeit; countries; drugs; health; international; medicines; organization; pharmaceutical; products; quality cache: cord-256852-lrz17bdx.txt plain text: cord-256852-lrz17bdx.txt item: #54 of 196 id: cord-257144-3q0un5rl author: Giri, Allan title: Mutagenic, Genotoxic and Immunomodulatory effects of Hydroxychloroquine and Chloroquine: a review to evaluate its potential to use as a prophylactic drug against COVID-19 date: 2020-09-02 words: 5582 flesch: 41 summary: Previously, we have evaluated the genetic toxicology of different drugs and chemicals including antimalarial drug CQ both in vitro and in vivo. The role of chloroquine supplementation in liquid holding recovery and ultraviolet lethality of Escherichia coli strains The comparative responses of Salmonella typhimurium TA1537 and TA97A to a range of reference mutagens and novel compounds Testing of chloroquine and quinacnne for mutagenicity in Drosophila melanogaster Comparison of the Ames assay and the induction of sister chromatid exchanges: results with ten pharmaceuticals and five selected agents Aspects of chloroquine mutagenicity Frameshift mutagenesis by chloroquine in Escherichia coli and Salmonella typhimurium Cortinas de Nava C. influence of the Uvr repair system on the mutagenicity of antiparasitic drugs Genetic toxicology testing of the antimalarial drugs Chloroquine and a new analog, AQ-13 Study of the evaluation of mutagenic effects of antimalarial drug chloroquine in Ames Salmonella assay Choloroquine inhibition of repair of DNA damage induced in mammalian cells by methyl methanesulfonate Cytogenetic effects of chloroquine in human lymphocyte cultures Simultaneous detection of chromosomal aberrations and sister-chromatid exchanges: experience with DNA intercalating agents Putative identification of functional interactions between DNA intercalating agents and topoisomerase II using the V79 in vitro micronucleus assay Anti-malarial chloroquine stimulate p53-apoptotic pathway in rat hepatocytes Genotoxicity of chloroquine in rat liver cells: protective role of free radical scavengers Action of chloroquine phosphate in rheumatoid arthritis. keywords: activation; cells; chloroquine; covid-19; drugs; effects; genotoxic; hcq; hydroxychloroquine; prophylactic; vitro; vivo cache: cord-257144-3q0un5rl.txt plain text: cord-257144-3q0un5rl.txt item: #55 of 196 id: cord-257318-jejgkcql author: Jain, K.K. title: Synthetic Biology and Personalized Medicine date: 2012-08-16 words: 6097 flesch: 31 summary: Engineering life through synthetic biology Emerging biomedical applications of synthetic biology Drug discovery and delivery in the 21st century Textbook of Personalized Medicine The role of nanobiotechnology in the development of personalized medicine Role of biological therapies in the development of personalized medicine Creation of a bacterial cell controlled by a chemically synthesized genome The changing economics of DNA synthesis Synthetic biology: applications come of age Breaking the code of DNA binding specificity of TAL-type III effectors De novo designed proteins from a library of artificial sequences function in Escherichia coli and enable cell growth Smart medication through combination of synthetic biology and cell microencapsulation Systems medicine and metabolic modelling Metabolic engineering for the production of clinically important molecules: omega-3 fatty acids, artemisinin, and taxol Sequence-specificity and energy landscapes of DNA-binding molecules Mammalian synthetic biology -from tools to therapies Synthetic biology moving into the clinic Resistance to dietinduced obesity in mice with synthetic glyoxylate shunt Rational design of a small molecule-responsive intramer controlling transgene expression in mammalian cells Anti-Borrelia burgdorferi antibody profile in post-Lyme disease syndrome Black WC 4th: Genetic elimination of dengue vector mosquitoes Engineering antibiotic production and overcoming bacterial resistance Screens, maps & networks: from genome sequences to personalized medicine Therapeutic synthetic gene networks Compartmentalized reactions as a case of softmatter biotechnology: synthesis of proteins and nucleic acids inside lipid vesicles Synthetic cells and organelles: compartmentalization strategies Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA Synthetic reversal of epigenetic silencing Bioinspired materials for controlling stem cell fate Synthetic biology: impact on the design of innovative vaccines Structure-based design of peptides that self-assemble into regular polyhedral nanoparticles A nonadjuvanted polypeptide nanoparticle vaccine confers long-lasting protection against rodent malaria Antigen-expressing immunostimulatory liposomes as a genetically programmable synthetic vaccine Antigen identification starting from the genome: a 'Reverse Vaccinology' approach applied to MenB Vaxign: the first web-based vaccine design program for reverse vaccinology and applications for vaccine development Genomics and the continuum of cancer care Future prospects for the cure of brain cancer Presidential Commission for the Study of Bioethical Issues: The Ethics of Synthetic Biology and Emerging Technologies. Synthetic cells could include essential components for a personalized therapy and would be a cheaper and more effective tool for treatment. keywords: biology; cancer; cells; design; development; dna; drug; engineering; gene; genome; medicine; metabolic; proteins; synthetic cache: cord-257318-jejgkcql.txt plain text: cord-257318-jejgkcql.txt item: #56 of 196 id: cord-257344-d13at1y5 author: Ghasemiyeh, Parisa title: COVID-19 Outbreak: Challenges in Pharmacotherapy Based on Pharmacokinetic and Pharmacodynamic Aspects of Drug Therapy in Patients with Moderate to Severe Infection date: 2020-09-18 words: 5690 flesch: 35 summary: According to recently published researches, the most common clinical presentations in COVID-19 patients were fever in 83% to 98% of patients, dry cough in 76 to 82%, and fatigue or myalgia in 11 to 44% of them. So close patient monitoring is required in COVID-19 patients with pre-existing cardiovascular disease who are planned to treat with lopinavir/ritonavir and sometimes alternative drugs might be considered 52 . keywords: antiviral; chloroquine; coronavirus; covid-19; disease; drug; hydroxychloroquine; lopinavir; patients; potential; ribavirin; ritonavir; treatment cache: cord-257344-d13at1y5.txt plain text: cord-257344-d13at1y5.txt item: #57 of 196 id: cord-257496-mirh80gn author: Hickey, Anthony J. title: Emerging trends in inhaled drug delivery date: 2020-07-12 words: 4693 flesch: 36 summary: This low-density morphology allows the delivery of 112mg of drug (4 capsules, 28mg/capsule) increasing the previous limit on dry powder drug delivery by 2 orders of magnitude. However, a formulation conundrum was exposed with this major advance in dry powder drug delivery. keywords: delivery; development; disease; dose; drug; formulation; inhaler; lung; powder; products; treatment cache: cord-257496-mirh80gn.txt plain text: cord-257496-mirh80gn.txt item: #58 of 196 id: cord-258128-qtmjgrml author: Mirjalili, Mahtabalsadat title: Coronavirus Disease 2019 (COVID-19) and Transplantation: Pharmacotherapeutic Management of Immunosuppression Regimen date: 2020-07-03 words: 6459 flesch: 30 summary: Table 1 shows a summary of medications which are used or suggested for the management of COVID-19 patients, according to recent studies. Sometimes, medications other than antivirals are used for symptomatic therapy or supportive care in COVID-19 patients. keywords: coronavirus; covid-19; drug; effects; kidney; liver; management; patients; recipients; risk; studies; transplant; treatment; use cache: cord-258128-qtmjgrml.txt plain text: cord-258128-qtmjgrml.txt item: #59 of 196 id: cord-258614-7unadw41 author: Ogidigo, Joyce Oloaigbe title: Natural phyto, compounds as possible noncovalent inhibitors against SARS-CoV2 protease: computational approach date: 2020-10-25 words: 8472 flesch: 38 summary: The six top screened Phyto-ligands (of the 86 compounds) with high binding energy, three FDA reference drugs and the apo-enzyme (APO) of the target was subjected to MD simulation. We went further to investigate the energetic inhibitory potency of the selected natural product in comparison with reference drugs. keywords: binding; compounds; cov-2; drugs; et al; figure; hydrogen; inhibitors; ligand; protease; protein; residues; sars; site; systems cache: cord-258614-7unadw41.txt plain text: cord-258614-7unadw41.txt item: #60 of 196 id: cord-260215-gsnjlhjd author: Dhanani, Jayesh title: Fundamentals of aerosol therapy in critical care date: 2016-10-07 words: 8323 flesch: 32 summary: The efficacy of aerosol drug therapy depends on drug-related factors (particle size, molecular weight), device factors, patient-related factors (airway anatomy, inhalation patterns) and mechanical ventilation-related factors (humidification, airway). Figure 2 shows the factors conducive for effective aerosol drug delivery in the critically ill mechanically ventilated and non-mechanically ventilated patient groups. keywords: aerosol; care; delivery; deposition; drug; effect; factors; flow; lung; nebulizers; patients; pneumonia; studies; therapy; use; ventilation cache: cord-260215-gsnjlhjd.txt plain text: cord-260215-gsnjlhjd.txt item: #61 of 196 id: cord-261170-arnwk287 author: Gallimore, W. title: Chapter 18 Marine Metabolites Oceans of Opportunity date: 2017-12-31 words: 7131 flesch: 37 summary: There are several marine compounds sourced from microbes which are of clinical significance. Trends in the discovery of new marine natural products from invertebrates over the last two decades À Where and what are we bioprospecting? keywords: activity; agents; alga; cancer; cell; compounds; cytotoxic; drug; evaluation; marine; metabolites; new; organisms; phase; potential; products; range; species; sponge; trials cache: cord-261170-arnwk287.txt plain text: cord-261170-arnwk287.txt item: #62 of 196 id: cord-261311-j6bmgmhz author: Parreiras Martins, Maria Auxiliadora title: Preparedness of pharmacists to respond to the emergency of the COVID-19 pandemic in Brazil: a comprehensive overview date: 2020-07-31 words: 4312 flesch: 32 summary: Rev Bras Ter Intensiva Liver and kidney injuries in COVID-19 and their effects on drug therapy; a letter to editor COVID-19 and older adults: what we know New understanding of the damage of SARS-CoV-2 infection outside the respiratory system Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy A proposal for staging COVID-19 coagulopathy Heparin: effects upon the glycocalyx and endothelial cells The versatile heparin in COVID-19 Stratifying therapeutic enoxaparin dose in morbidly obese patients by BMI class: a retrospective cohort study Guidance on minimizing risk of drug-induced ventricular arrhythmia during treatment of COVID-19: a statement from the Canadian Heart Rhythm Society Antibiotic use in the intensive care unit: optimization and de-escalation COVID-19: the uninvited guest in the intensive care unit (ICU) implications for pharmacotherapy COVID-19 and the potential long-term impact on antimicrobial resistance Involving antimicrobial stewardship programs in COVID-19 response efforts: all hands on deck Coronavirus disease 2019 (COVID-19) and pregnancy: what obstetricians need to know Hyperinflammatory shock in children during COVID-19 pandemic Breastfeeding and respiratory antivirals: coronavirus and influenza COVID-19 and cancer: a comprehensive review A standardized, structured approach to identifying drug-related problems in the intensive care unit: FASTHUG-MAIDENS Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Prediction models for diagnosis and prognosis of COVID-19 infection: systematic review and critical appraisal The laboratory tests and host immunity of COVID-19 patients with different severity of illness Development and validation of a clinical risk score to predict the occurrence of critical illness in hospitalized patients with COVID-19 Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease COVID19 coagulopathy in Caucasian patients Atrial fibrillation: prevalence in a large database of primary care patients in Brazil Acknowledgements COVID-19 patients may present high risk in the use of medications and clinical pharmacists can contribute substantially as part of a multidisciplinary team to improve outcomes in drug therapy in severe and critical illness. keywords: brazil; care; coronavirus; covid-19; disease; drug; health; pandemic; patients; pharmacists; pharmacy; use cache: cord-261311-j6bmgmhz.txt plain text: cord-261311-j6bmgmhz.txt item: #63 of 196 id: cord-262442-kjgpriow author: Scalia, Santo title: Quercetin solid lipid microparticles: A flavonoid for inhalation lung delivery date: 2013-05-13 words: 5535 flesch: 45 summary: Quercetin microparticles were prepared by o/w emulsification via a phase inversion technique, using tristearin as the lipid component and phosphatidylcholine as an emulsifier. Results showed that quercetin SLMs could be formulated as dry powder suitable for inhalation drug delivery (20.5 ± 3.3% fine particle fraction ⩽4.46 μm) that was absorbed, via a linear kinetic model across the Calu-3 monolayer (22.32 ± 1.51% over 4 h). keywords: calu-3; cells; delivery; drug; et al; lipid; min; particle; powder; quercetin; size; slms; studies; study; transport; tristearin cache: cord-262442-kjgpriow.txt plain text: cord-262442-kjgpriow.txt item: #64 of 196 id: cord-263074-qxiynbl2 author: Nabi, Bushra title: Nano-based anti-tubercular drug delivery: an emerging paradigm for improved therapeutic intervention date: 2020-05-16 words: 5684 flesch: 32 summary: Drug Des Dev Ther New active formulations against M. tuberculosis: bedaquiline encapsulation in lipid nanoparticles and chitosan nanocapsules Comparative study of oral lipid nanoparticle formulations (LNFs) for chemical stabilization of antitubercular drugs: physicochemical and cellular evaluation Role of PEG 2000 in the surface modification and physicochemical characteristics of pyrazinamide loaded nanostructured lipid carriers Targeted macrophages delivery of rifampicinloaded lipid nanoparticles to improve tuberculosis treatment Nanoemulsions in drug delivery: formulation to medical application Critical physicochemical and biological attributes of nanoemulsions for pulmonary delivery of rifampicin by nebulization technique in tuberculosis treatment Alternative pharmaceutical formulation for oral administration of rifampicin Enhanced brain penetration of pretomanid by intranasal administration of an oil-in-water nanoemulsion Macrophages targeted drug delivery as a key therapy in infectious disease Development and evaluation of a dry powder formulation of liposomeencapsulated oseltamivir phosphate for inhalation A thermo-responsive and self-healing liposome-in-hydrogel system as an antitubercular drug carrier for localized bone tuberculosis therapy Enhanced antitubercular activity, alveolar deposition and macrophages uptake of mannosylated stable nanoliposomes Inhalable liposomes of Glycyrrhiza glabra extract for use in tuberculosis: formulation, in vitro characterization, in vivo lung deposition and in vivo pharmacodynamic studies Targeted theranostic liposomes: rifampicin and ofloxacin loaded pegylated liposomes for theranostic application in mycobacterial infections Conjugation of isoniazid to a zinc phthalocyanine via hydrazine linkage for pH-dependent liposomal controlled release Preparation and characterization of isoniazid loaded crude soybean lecithin liposomes Enhancement of the effect of BCG vaccine against tuberculosis using DDA/ The lungs appear as an attractive target for the therapeutic delivery of anti-TB drugs. keywords: anti; delivery; drug; formulation; lipid; nanoparticles; nps; release; rif; rifampicin; system; tuberculosis cache: cord-263074-qxiynbl2.txt plain text: cord-263074-qxiynbl2.txt item: #65 of 196 id: cord-263312-x7f0hn7f author: Tzelepis, Ilias title: Drosophila melanogaster: a first step and a stepping-stone to anti-infectives date: 2013-08-28 words: 3757 flesch: 31 summary: Finally, Drosophila infection and inflammation can easily be studied in relation to aging overcoming the barrier of long experimental time [10] . For example, Drosophila cells have been used in genome-wide RNAi screens to rapidly identify genes required for replication of influenza and dengue viruses keywords: anti; cells; drosophila; drug; flies; host; immune; infection; mammals; melanogaster; model cache: cord-263312-x7f0hn7f.txt plain text: cord-263312-x7f0hn7f.txt item: #66 of 196 id: cord-263803-0n41gylj author: Villoutreix, Bruno O. title: Prevention of COVID-19 by drug repurposing: rationale from drugs prescribed for mental disorders date: 2020-06-25 words: 1287 flesch: 39 summary: key: cord-263803-0n41gylj authors: Villoutreix, Bruno O.; Beaune, Philippe H.; Tamouza, Ryad; Krishnamoorthy, Rajogapal; Leboyer, Marion title: Prevention of COVID-19 by drug repurposing: rationale from drugs prescribed for mental disorders date: 2020-06-25 journal: Drug Discov Today DOI: 10.1016/j.drudis.2020.06.022 sha: doc_id: 263803 cord_uid: 0n41gylj nan At present, no treatments or vaccines are available to treat or prevent the coronavirus SARS-Cov-2 infection. If we take the example of the highly debated anti-malarial Chloroquine and Hydroxychloroquine that have in vitro antiviral activity, these compounds are also CAD and PLD compounds (they display two ionizable amine groups while most often, psychotropic drugs contain only one ionizable amine group). keywords: activity; cov-2; drugs; sars cache: cord-263803-0n41gylj.txt plain text: cord-263803-0n41gylj.txt item: #67 of 196 id: cord-263840-1t4ykc01 author: Altay, Ozlem title: Current status of COVID-19 therapies and drug repositioning applications date: 2020-06-20 words: 2103 flesch: 22 summary: No specific 124 therapies for COVID-19 is approved by U.S. Food and Drug Administration (FDA) so far but many 125 previously approved drugs, as an efficient approach to drug discovery named drug repurposing, is being 126 tested on COVID-19. In-silico drug repurposing methodologies have accelerated the studies in drug discovery through the use 250 of data mining approaches, bioinformatics techniques, and predictive models for determining the efficacy 251 and safety of the drugs. keywords: coronavirus; covid-19; discovery; drug; patients; repurposing; sars; treatment cache: cord-263840-1t4ykc01.txt plain text: cord-263840-1t4ykc01.txt item: #68 of 196 id: cord-263874-q0egnzwf author: Khan, Md. Arif title: Comparative molecular investigation of the potential inhibitors against SARS-CoV-2 main protease: a molecular docking study date: 2020-07-22 words: 2996 flesch: 40 summary: I. Basis, form, scope, parameterization, and performance of MMFF94 Molecular-docking study of malaria drug target enzyme transketolase in Plasmodium falciparum 3D7 portends the novel approach to its treatment Treating diabetes mellitus: Pharmacophore based designing of potential drugs from gymnema sylvestre against insulin receptor protein Identification of potential inhibitor and enzyme-inhibitor complex on trypanothione reductase to control Chagas disease Assessment of structurally and functionally high-risk nsSNPs impacts on human bone morphogenetic protein receptor type IA (BMPR1A) by computational approach Swiss-PDB viewer (deep view) Genomic characterization of a novel SARS-CoV-2 PubChem substance and compound databases Combination therapy with lopinavir/ritonavir, ribavirin and interferona for Middle East respiratory syndrome Halting coronavirus polymerase Fast empirical pKa prediction by Ewald summation Making optimal use of empirical energy functions: Force-field parameterization in crystal space New ways to boost molecular dynamics simulations Potential inhibitors against 2019-nCoV coronavirus M protease from clinically approved medicines Exploring the potent inhibitors and binding modes of phospholipase A2 through in silico investigation Supersized virtual screening offers potent leads Computational studies of drug repurposing and synergism of lopinavir, oseltamivir and ritonavir binding with SARS-CoV-2 protease against COVID-19 Drug repurposing: Progress, challenges and recommendations The RCSB protein data bank: Moving drugs from concept to the clinic On the origin and continuing evolution of SARS-CoV-2 AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods Epirubicin directly promotes hepatitis B virus (HBV) replication in stable HBV-expressing cell lines: A novel mechanism of HBV reactivation following anticancer chemotherapy Computational screening of antagonists against the SARS-CoV-2 (COVID-19) coronavirus by molecular docking The first-in-class peptide binder to the SARS-CoV-2 spike protein The authors declares that they have no conflict of interest. keywords: beta; binding; complex; cov-2; drug; protease; protein; sars cache: cord-263874-q0egnzwf.txt plain text: cord-263874-q0egnzwf.txt item: #69 of 196 id: cord-264779-71s7e18i author: Neumann, Natalie R. title: Medical Toxicology and COVID-19: Our Role in a Pandemic date: 2020-04-30 words: 1930 flesch: 35 summary: Lastly, poison centers, historically considered an underutilized source for reporting adverse drug reactions, may be more mindful of tracking and reporting toxicity from novel therapies [26] . The Lancet Respiratory Medicine FDA advises patients on use of nonsteroidal anti-inflammatory drugs (NSAIDs) for COVID-19 A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirusinduced lung injury Liver injury in COVID-19: management and challenges Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Pathological findings of COVID-19 associated with acute respiratory distress syndrome Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study COVID-19 and the liver: little cause for concern Insufficient stocking of poisoning antidotes in hospital pharmacies Availability of antidotes at acute care hospitals in Ontario National audit of antidote stocking in acute hospitals in the UK Expert consensus guidelines for stocking of antidotes in hospitals that provide emergency care Royal College of Emergency Medicine and National Poisons Information Service Reporting of adverse drug reactions by poison control centres in the US MedWatch: keywords: covid-19; drug; hospital; information; medical; patients; toxicology cache: cord-264779-71s7e18i.txt plain text: cord-264779-71s7e18i.txt item: #70 of 196 id: cord-264867-ezsy76mx author: Rahman, Hamidur title: The recent advancement of low-dimensional nanostructured materials for drug delivery and drug sensing application: A brief review date: 2020-09-30 words: 29153 flesch: 41 summary: First, N. Abdolahi et al. investigated the adsorption properties of CXB drug adsorption on B 12 N 12 fullerene (BNNC) and found that BNNC can be a potential candidate for the nano-vehicle of CXB to transfer it into the targeted cell [367] . Final results of the CONKO 003 study Efficacy and safety profile of gemcitabine in nonsmall-cell lung cancer: A phase II study Activity of gemcitabine in patients with non-small cell lung cancer: A multicentre, extended phase II study Gemcitabine plus paclitaxel versus paclitaxel monotherapy in patients with metastatic breast cancer and prior anthracycline treatment Fatal pulmonary toxicity resulting from treatment with gemcitabine Severe acute lung injury induced by gemcitabine A density functional theory-based analysis of the structural, topological and electronic properties of gemcitabine drug adsorption on the pyrrolidine functionalized single-walled carbon nanotube Flutamide-induced hepatotoxicity: report of a case series Severe gynecomastia due to anti androgens intake: A case report and literature review Mechanism of action and pure antiandrogenic properties of flutamide Assessment of the adsorption mechanism of Flutamide anticancer drug on the functionalized single-walled carbon nanotube surface as a drug delivery vehicle: An alternative theoretical approach based on DFT and MD Assessment of solvent effects on the interaction of Carmustine drug with the pristine and COOH-functionalized single-walled carbon nanotubes: A DFT perspective Metformin use and prostate cancer in Caucasian men: Results from a population-based case-control study Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer Antidiabetic Therapies Affect Risk of Pancreatic Cancer Quantum Chemical Study on the adsorption of metformin drug on the surface of pristine, Si-and Al-doped (5, 5) SWCNTs, Phys. keywords: adsorbate; adsorbent; adsorption energy; adsorption properties; anticancer drug; bnnt; boron; carbon; charge; chemical; debye; decrease; delivery system; dft; drug adsorption; drug carrier; drug delivery; drug interaction; drug sensor; drugs; effects; energy gap; et al; functional; graphene; increase; interaction; interaction energy; kcal; l energy; mol; nanotubes; nitride; potential; pristine; r n; structure; study; swcnt; system; theory cache: cord-264867-ezsy76mx.txt plain text: cord-264867-ezsy76mx.txt item: #71 of 196 id: cord-265699-0socw0hp author: Ortega, Miguel Ángel title: Dendrimers and Dendritic Materials: From Laboratory to Medical Practice in Infectious Diseases date: 2020-09-14 words: 11158 flesch: 36 summary: An assessment of the merits of covalent conjugation compared to noncovalent encapsulation Dendrimers for gene delivery-a potential approach for ocular therapy? PEGylated PAMAM dendrimers as a potential drug delivery carrier: in vitro and in vivo comparative evaluation of covalently conjugated drug and noncovalent drug inclusion complex Function oriented molecular design: Dendrimers as novel antimicrobials Dendrimers and dendritic polymers as anti-infective agents: New antimicrobial strategies for therapeutic drugs Dendrimers-revolutionary drugs for infectious diseases Application of dendrimers for the treatment of infectious diseases In Dendrimer Chemistry: Synthetic Approaches towards Complex Architectures Bench-to-bedside translation of dendrimers: Reality or utopia? PLL differ from other dendrimers such as PAMAM and PPI in the asymmetry of their branching cell, which inevitably influences the encapsulation properties as they possess no interior void space [37] . keywords: activity; agents; approach; bacteria; carbosilane; cells; delivery; dendrimers; development; diagnosis; diseases; drug; figure; groups; hiv; infections; pamam; peptide; prevention; prion; resistance; treatment; use cache: cord-265699-0socw0hp.txt plain text: cord-265699-0socw0hp.txt item: #72 of 196 id: cord-265848-afkeuwup author: None title: Chapter 2 Emergency Management of Poisoning date: 2007-12-31 words: 27431 flesch: 34 summary: small bowel obstruction secondary to amitriptyline overdose therapy Rectal ulcer with massive hemorrhage due to activated charcoal treatment in oral organophosphate poisoning Intestinal pseudo-obstruction following the use of enteral charcoal and sorbitol and mechanical ventilation with papaveretum sedation for theophylline poisoning Charcoal stercolith with intestinal perforation in a patient treated for amitriptyline ingestion Treatment with activated charcoal complicated by gastrointestinal obstruction requiring surgery Multiple doseactivated charcoal as a cause of acute appendicitis Small-bowel obstruction secondary to activated charcoal and adhesions Position statement: cathartics. In referred patients who have already been hospitalized elsewhere, ventricular arrhythmia may be due to hyperkalemia because renal failure may have ensued; in such patients, IV sodium bicarbonate, glucose/insulin, and, if necessary, calcium chloride administration may be warranted. keywords: acid; acute; administration; agents; blood; burns; calcium; case; charcoal; clearance; decontamination; dialysis; drug; effects; efficacy; elimination; extracorporeal; failure; gastrointestinal; glycol; hemodialysis; ingestion; intoxication; intubation; management; mdac; overdose; patient; peritoneal; poisoning; pressure; removal; skin; study; theophylline; therapy; toxicity; treatment; use; water cache: cord-265848-afkeuwup.txt plain text: cord-265848-afkeuwup.txt item: #73 of 196 id: cord-266294-ua22udlc author: Koch, Oliver title: 29 Antiviral drugs date: 2010-12-31 words: 10818 flesch: 39 summary: Metabolism The hemochromatosis gene polymorphism HFE 187C> G and possibly mitochondrial haplogroup J gave relative protection against lipoatrophy during antiretroviral drug therapy in a trial in which 96 patients were randomized to didanosine þ stavudine or zidovudine þ lamivudine, combined with efavirenz and/ or nelfinavir in AIDS Clinical Trials Group (ACTG) 384 sub-study A5005s (20 C ). The use of isoniazid preven tive therapy during antiretroviral drug therapy did not increase the risk of hepatotoxicity. keywords: abacavir; combination; dose; drug; efavirenz; hepatitis; hiv; lamivudine; nevirapine; patients; ribavirin; ritonavir; stavudine; study; tenofovir; therapy; tipranavir; treatment; women; zidovudine cache: cord-266294-ua22udlc.txt plain text: cord-266294-ua22udlc.txt item: #74 of 196 id: cord-267608-0odu8lus author: Chen, Daohong title: Innovative highlights of clinical drug trial design date: 2020-06-03 words: 4167 flesch: 23 summary: Clinical trial plays an indispensable role in evaluating efficacy and safety of therapeutic agents prior to marketing for human use, and has been constantly co-evolving along with the dynamic interactions between cutting-edge scientific discoveries and regulatory policy updating [2, 3] . In this light, the article herein highlights an array of outstanding developments in the perspective of drug trial design, being corroborated by notable successes in the clinical settings. keywords: clinical; development; disease; drug; efficacy; orphan; patients; phase; study; trial cache: cord-267608-0odu8lus.txt plain text: cord-267608-0odu8lus.txt item: #75 of 196 id: cord-267979-k70gnrdw author: Yıldız-Peköz, Ayca title: Advances in Pulmonary Drug Delivery date: 2020-09-23 words: 3263 flesch: 34 summary: The development of modern-day inhalers, e.g., pressurised metered-dose inhalers (pMDIs) and more recently, dry powder inhalers (DPIs), jet and vibrating mesh nebulisers (VMNs), and soft mist inhalers (SMIs), has given pulmonary drug delivery a momentum boost that transformed a therapeutic niche into a market predicted to hit US$41.5 billion by 2026 In this Special Issue, a cross-section of current research in the field of pulmonary drug delivery is published. keywords: aerosol; delivery; dose; drug; flow; formulation; inhalation; lung; pulmonary cache: cord-267979-k70gnrdw.txt plain text: cord-267979-k70gnrdw.txt item: #76 of 196 id: cord-268088-y4vg7frb author: Montané, Xavier title: Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy date: 2020-07-23 words: 11135 flesch: 39 summary: Several research groups have proved the cytotoxicity of kaempferol against breast cancer cells both in vitro and in vivo: -By inhibiting the growth of cancer cells, Flavonols are a class of flavonoids based on the backbone 3-hydroxyflavone. Several research groups have proved the cytotoxicity of kaempferol against breast cancer cells both in vitro and in vivo: -By inhibiting the growth of cancer cells, -By stopping the progression and proliferation of cancer cells, and -By inducing cancer cells apoptosis. keywords: acid; activity; anticancer; apigenin; apoptosis; breast; breast cancer; cancer; cancer cells; compounds; drug; effects; flavonoids; honokiol; plants; polyphenols; properties; resveratrol; therapy cache: cord-268088-y4vg7frb.txt plain text: cord-268088-y4vg7frb.txt item: #77 of 196 id: cord-268283-eja8fkwv author: Iftikhar, Hafsa title: Identification of potential inhibitors of three key enzymes of SARS-CoV2 using computational approach date: 2020-06-09 words: 4828 flesch: 40 summary: In this regard, several recent studies have been conducted using computational methods to screen libraries of approved drugs or drug-like molecules to identify potential inhibitors of different viral proteins, particularly, RdRp and 3CL-protease [13] Moreover, several other studies have also been reported contributing to the efforts in identifying approved drugs for repurposing or drug candidates or leads to develop drugs against SARS-CoV-2. keywords: 3cl; binding; cov-2; docking; drug; helicase; potential; protease; proteins; sars; structure cache: cord-268283-eja8fkwv.txt plain text: cord-268283-eja8fkwv.txt item: #78 of 196 id: cord-270516-9ol1209i author: Singh, Bhupinder title: Functionalized carbon nanotubes and their promising applications in therapeutics and diagnostics date: 2016-04-15 words: 5926 flesch: 32 summary: Multiwalled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics Laser ablation process for single-walled carbon nanotube production Synthesis of carbon nanotubes Growth, structure, and properties of graphite whiskers Advancement in carbon nanotubes: basics, biomedical applications and toxicity Cobalt-catalysed growth of carbon nanotubes with single-atomic-layer walls Polymer functionalized single walled carbon nanotubes mediated drug delivery of gliotoxin in cancer cells Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice Carbon nanotubes for the delivery of therapeutic molecules Applications of carbon nanotubes in drug delivery PEG-modified carbon nanotubes in biomedicine: current status and challenges ahead Noncovalent engineering of carbon nanotube surfaces by rigid, functional conjugated polymers DNA and carbon nanotubes as medicine Hyaluronate tethered, smart multiwalled carbon nanotubes for tumor-targeted delivery of doxorubicin Carbon nanotubes for transdermal drug delivery Aligned multi-walled carbon nanotube-reinforced composites: processing and mechanical characterization Soluble single-walled carbon nanotubes as longboat delivery systems for platinum(IV) anticancer drug design Carbon nanotubes as functional excipients for nanomedicines: I. pharmaceutical properties Structural flexibility of carbon nanotubes Single-shell carbon nanotubes of 1-nm diameter Production of CNT-taxol-embedded PCL microspheres using an ammonium-based room temperature ionic liquid: as a sustained drug delivery system Chemical vapor deposition of carbon nanotubes: a review on growth mechanism and mass production Carbon nanotubes as nanomedicines: from toxicology to pharmacology Functionalized carbon nanotubes for anticancer drug delivery Nanotechnology policy and environmental regulatory issues Selection of quantum dot wavelengths for biomedical assays and imaging Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery Drug delivery with carbon nanotubes for in vivo cancer treatment Carbon nanotubes in biology and medicine: in vitro and in vivo detection, imaging and drug delivery Solubilizing carbon nanotubes through noncovalent functionalization. Several studies on the fate of nanotubes in the body have suggested that the functionalized CNTs loaded with drug molecules could easily pass into the cells and further into the cell nucleus, thus attaining targeted drug delivery both at cellular and nuclear levels (Mehra et al., 2015) . keywords: addition; cancer; carbon; cells; cnts; delivery; drug; functionalization; molecules; mwcnts; nanotubes; properties; surface; targeting cache: cord-270516-9ol1209i.txt plain text: cord-270516-9ol1209i.txt item: #79 of 196 id: cord-270622-aofva2ab author: Li, Qizhang title: Potential clinical drugs as covalent inhibitors of the priming proteases of the spike protein of SARS-CoV-2 date: 2020-08-26 words: 2833 flesch: 39 summary: [11] and MERS-CoV Historically, the drug discovery practice mainly focuses on non-covalent drugs due to potential off-64 target effects and toxicity issues of irreversible covalent drugs However, recent years have 65 witnessed the resurgence of covalent drugs because many people have realized that compared to non-66 covalent drugs, covalent drugs might have extra advantages including: (i) better biochemical 67 efficiency since they are more competitive than non-covalent endogenous substrates and co-factors 68 [14]; (ii) lower patient burden and less drug resistance due to lower and less frequent dosing To 70 help the discovery of covalent drugs, we previously established a steric-clashes alleviating receptor 71 (SCAR) strategy [17] for the in silico docking and screening of covalent drugs enlightened by in 72 silico protein design org) containing approved and in-trial drugs with known warhead groups targeting 77 cysteine (CatB/CatL) or serine (TMPRSS2). keywords: catb; covalent; drugs; inhibitors; protein; sars; tmprss2 cache: cord-270622-aofva2ab.txt plain text: cord-270622-aofva2ab.txt item: #80 of 196 id: cord-272060-o0wx0add author: Li, Allen title: Drug-drug interactions affecting drug levels of direct oral anticoagulants in the real world: A systematic review() date: 2020-08-11 words: 4323 flesch: 30 summary: 32, 33 It is a widely used reference standard for determining the probability of drug interactions and has been shown through a 2015 systematic review to overcome limitations present in other assessment instruments. Patients on direct oral anticoagulants (DOACs) can encounter drug interactions 2. keywords: anticoagulants; bleeding; case; cyp3a4; doac; drug; events; interactions; patients cache: cord-272060-o0wx0add.txt plain text: cord-272060-o0wx0add.txt item: #81 of 196 id: cord-273656-xo82zyi6 author: Burry, Lisa D. title: It Takes a Village… Contending with Drug Shortages During Disasters date: 2020-08-14 words: 4567 flesch: 31 summary: Therapeutic alternatives and strategies for drug conservation in the intensive care unit during times of drug shortages: a report of the Ontario COVID-19 ICU Drug Task Force A Toolkit for Improved Understanding and Transparency of Drug Shortage Response in Canada The drug shortage crisis in the United States: causes, impact, and management strategies Drug shortages in developed countries -reasons, therapeutic consequences, and handling Medication shortages during the COVID-19 crisis: what we must do Economic and technological drivers of generic sterile injectable drug shortages US Propofol Drug Shortages: A Review of the Problem and Stakeholder Analysis Why are there so many drug shortages? Drug Shortages in the United States: Are Some Prices Too Low? While cisatracurium is the agent of choice for many institutions, in the setting of drug shortages, consider reserving cisatracurium (and atracurium) for patients with endorgan dysfunction and use vecuronium or rocuronium when both kidney and liver function are preserved Addressing the global shortage of, and access to, medicines and vaccines Report by the Director-General BACKGROUND Medicines shortages: Global approaches to addressing shortages of essential medicines in health systems Medicine shortages: Gaps between countries and global perspectives Essential ICU drug shortages for COVID-19: what can frontline clinicians do? Potential of chloroquine and hydroxychloroquine to treat COVID-19 causes fears of shortages among people with systemic lupus erythematosus keywords: care; countries; covid-19; drug; manufacturers; patients; pharmaceutical; production; shortages; strategies; supply; use cache: cord-273656-xo82zyi6.txt plain text: cord-273656-xo82zyi6.txt item: #82 of 196 id: cord-273716-vv3pyft4 author: Khosravi-Darani, Kianoush title: The role of high-resolution imaging in the evaluation of nanosystems for bioactive encapsulation and targeted nanotherapy date: 2007-07-03 words: 10235 flesch: 25 summary: Scanning tunneling microscopy study of cytochrome P450 2B4 incorporated in proteoliposomes Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agent Targeted drug delivery in cancer therapy Nanosystems in drug targeting: opportunities and challenges Characterization of a novel costimulatory molecule: a 155-160 kD B cell surface protein provides accessory help to CD 4+ T cells to proliferate and differentiate Targeting liposomes with protein drugs to the blood-brain barrier in vitro The emerging nanomedicine landscape Nanotechnology applications in medicine Nanotechnology: a new look Penetration enhancers Magnetic nanoparticles of Fe and Nd-Fe-B alloy encapsulated in carbon shells for drug delivery systems: study of the structure and interaction with the living cells PLGA/mesoporous silica hybrid structure for controlled drug release Recent advances in micro-and nanoencapsulation of food ingredients Ab initio study of pristine and Si-doped capped carbon nanotubes interacting with nimesulide molecules Scanning tunnelling microscopy investigation of liposome-DNA-Ca 2+ complexes Cochleates: new lipidbased drug delivery system Cochleates: lipid-based vehicles for gene delivery -concept, achievements and future development Nanocochleate cylinders for oral and parenteral delivery of drugs Organspecific gene expression in the rhesus monkey eye following intravenous nonviral gene transfer Lipid spin labeling and n.m.r. study of the interaction between polyadenylic acid:-polyuridilic acid duplex and egg phosphatidylcholine vesicles. An ideal dendrimer as bioactive delivery system, however, must also be nontoxic, nonimmunogenic and biodegradable (for a review, see Aulenta et al., 2003) . keywords: applications; bioactive; delivery; dna; drug; et al; gene; lipid; liposomes; material; microscopy; molecules; mozafari; nanocarriers; nanoliposomes; nanoparticles; nanotechnology; properties; release; size; systems; targeting; techniques cache: cord-273716-vv3pyft4.txt plain text: cord-273716-vv3pyft4.txt item: #83 of 196 id: cord-273941-gu6nnv9d author: Chandran, Uma title: Chapter 5 Network Pharmacology date: 2017-12-31 words: 10268 flesch: 30 summary: Molecular dockingÀbased NEP can be a useful tool to computationally elucidate the combinatorial effects of traditional medicine to intervene disease networks (Gu et al., 2013c ). Disease and Gene Annotation (DGA), a database that provides a comprehensive and integrative annotation of human genes in disease networks, is useful in identifying the disease type that each indication belongs to (Peng et al., 2013) . keywords: action; analysis; approach; bioactives; data; database; discovery; disease; drug; et al; formulation; information; interactions; mechanism; medicine; network; pharmacology; protein; study; targets; tcm; triphala cache: cord-273941-gu6nnv9d.txt plain text: cord-273941-gu6nnv9d.txt item: #84 of 196 id: cord-274307-kl0uvrbw author: Bordet, Régis title: Is the drug a scientific, social or political object? date: 2020-05-23 words: 1393 flesch: 35 summary: Pragmatic trials, adaptive trials using the Bayesian approach, studies with external comparators, trials on small samples, taking into account secondary assessment criteria and the use of biomarkers are all methodological innovations that aim to make the framework of controlled trials more flexible in order to speed up or improve the evaluation of drugs, without abandoning the major and basic principle of comparison [1, 2] . Will the ability to control drug policy in all its aspects (innovation, rapid assessment, production) become a diplomatic weapon or even a propaganda tool for external or internal propaganda? keywords: drug; health; social; trials cache: cord-274307-kl0uvrbw.txt plain text: cord-274307-kl0uvrbw.txt item: #85 of 196 id: cord-274401-pjyvg53w author: Hrkach, Jeff title: From micro to nano: evolution and impact of drug delivery in treating disease date: 2020-05-08 words: 2059 flesch: 34 summary: The developments of many of today's most innovative therapeutics are utilizing nanoparticle drug delivery systems, and for our scope, we will focus on RNA nanomedicines. key: cord-274401-pjyvg53w authors: Hrkach, Jeff; Langer, Robert title: From micro to nano: evolution and impact of drug delivery in treating disease date: 2020-05-08 journal: Drug Deliv Transl Res DOI: 10.1007/s13346-020-00769-6 sha: doc_id: 274401 cord_uid: pjyvg53w Over the past 50 years, drug delivery breakthroughs have enabled the approval of several important medicines. keywords: cancer; delivery; drug; medicines; mrna; release cache: cord-274401-pjyvg53w.txt plain text: cord-274401-pjyvg53w.txt item: #86 of 196 id: cord-274474-u2fdicgz author: Majumder, Joydeb title: Targeted Nanotherapeutics for Respiratory Diseases: Cancer, Fibrosis, and Coronavirus date: 2020-10-13 words: 10114 flesch: 42 summary: [89] Here, we have summarized recent reports of several lipid-based nanosystems including liposome, nanostructured lipid carriers (NLCs), and micelles and their application as targeted drug delivery systems. [1, 2] Therefore, methods of developing new therapeutic solutions as well as improving the current therapies for the common lung diseases such as asthma, cystic fibrosis, chronic obstructive pulmonary disease, lung cancer, and coronavirus infections remain the main focus in the fields of targeted drug delivery. keywords: anticancer; cancer; cancer cells; cells; delivery; drug; figure; gene; lipid; lung; lung cancer; nanoparticles; sars; system; targeting; therapeutics; treatment; tumor cache: cord-274474-u2fdicgz.txt plain text: cord-274474-u2fdicgz.txt item: #87 of 196 id: cord-275772-pmf6stua author: Jourdan, Jean‐Pierre title: Drug repositioning: a brief overview date: 2020-04-17 words: 3241 flesch: 36 summary: The main aim of drug repositioning is to combat the attrition and rising costs which, according to 'Eroom's law', [23] are having a dramatic effect on the number of new drugs entering the pharmaceuticals market. Drug repurposing: progress, challenges and recommendations Drug repositioning: identifying and developing new uses for existing drugs Drug repositioning and repurposing: terminology and definitions in literature Selective optimization of side activities: the SOSA approach On the integration of in silico drug design methods for drug repurposing Systematic drug repositioning for a wide range of diseases with integrative analyses of phenotypic and molecular data Laying in silico pipelines for drug repositioning: a paradigm in ensemble analysis for neurodegenerative diseases Can you teach old drugs new tricks? keywords: aspirin; data; disease; drug; effect; indication; repositioning; repurposing cache: cord-275772-pmf6stua.txt plain text: cord-275772-pmf6stua.txt item: #88 of 196 id: cord-275827-r86ygqmy author: Lapeyre-Mestre, Maryse title: Addictovigilance contribution during COVID-19 epidemic and lockdown in France date: 2020-06-23 words: 5012 flesch: 30 summary: Lessons from 15 years of pharmacoepidemiological contribution Ten-year trend of opioid and non-opioid analgesic use in the French adult population A capture-recapture method for estimating the incidence of off-label prescriptions: the example of baclofen for alcohol use disorder in France Identification and tracking of Addictovigilance signals in general practice: which interactions between the general practitioners and the French Addictovigilance Network? Parachuting psychoactive substances: pharmacokinetic clues for harm reduction Medical complications of psychoactive substances with abuse risks: Detection and assessment by the network of French addictovigilance centres Use of new psychoactive substances to mimic prescription drugs: The trend in France Identifying Life-Threatening Admissions for Drug Dependence or Abuse (ILIADDA): derivation and validation of a model Les CAARUD, lieux privilégiés d'émergence de signaux pour l'addictovigilance Arrêté du 19 mars 2020 complétant l'arrêté du 14 mars 2020 portant diverses mesures relatives à la lutte contre la propagation du virus COVID-19 Intérêt de la mise à disposition de la naloxone auprès des usagers de drogues pour le traitement d'urgence de surdosage d'opioïdes Améliorer la balance bénéfices/risques de la méthadone en respectant ses spécificités pharmacologiques Psychopathological consequences of confinement Pharmacovigilance et addictovigilance dans le contexte du COVID-19 : une surveillance renforcée Detection of signals of abuse and dependence applying disproportionality analysis Early signal of diverted use of tropicamide eye drops in France Pregabalin use disorder and secondary nicotine dependence in a woman with no substance abuse history Patterns of gabapentin and pregabalin use and misuse: Results of a population-based cohort study in France Drug abuse monitoring: which pharmacoepidemiological resources at the European level? Warning on increased serious health complications related to non-medical use of nitrous oxide Use of multiple sources and capture-recapture method to estimate the frequency of hospitalizations related to drug abuse Evidence of clonazepam abuse liability: results of the tools developed by the French Centers for Evaluation and Information on Pharmacodependence (CEIP) network Slow-release oral morphine sulfate abuse: results of the postmarketing surveillance systems for psychoactive prescription drug abuse in France Example of an investigation of an emergent phenomenon in addiction vigilance: the case of methylphenidate Medical prescriptions falsified by the patients: a 12-year national monitoring to assess prescription drug diversion Pharmaciens d'officine, étudiants en pharmacie et demandes de médicaments à base de codéine : étude observationnelle Disproportionality analysis for the assessment of abuse and dependence potential of pregabalin in the French Pharmacovigilance database Detecting the diverted use of psychoactive drugs by adolescents and young adults: A pilot study Site de l'association française des centres d'addictovigilance The French Addictovigilance network would like to acknowledge all persons in the 13 addictovigilance centres who participated in the active monitoring during this period (all health professionals who reported cases during the period, and persons in charge of psychoactive drugs at the ANSM (Aldine Fabreguettes, Emilie Monzon, Charlotte Pion, Nathalie Richard). This monitoring program has been useful to identify addictovigilance signals or characterize the abuse potential of prescription drugs [32, [39] keywords: abuse; addictovigilance; covid-19; drugs; health; lockdown; methadone; monitoring; network; period; prescription; substances cache: cord-275827-r86ygqmy.txt plain text: cord-275827-r86ygqmy.txt item: #89 of 196 id: cord-275828-c6d6nk7x author: Mikasa, Keiichi title: JAID/JSC Guidelines for the Treatment of Respiratory Infectious Diseases: The Japanese Association for Infectious Diseases/Japanese Society of Chemotherapy – The JAID/JSC Guide to Clinical Management of Infectious Disease/Guideline-preparing Committee Respiratory Infectious Disease WG date: 2016-07-31 words: 39699 flesch: 37 summary: In the treatment of hospital-acquired pneumonia, the duration of antimicrobial therapy generally tends to be longer than required for the following reasons: opacity on chest X-ray often remains for reasons other than pneumonia even after the start of antimicrobial drug treatment; and there may be a large number of latent nonpneumonia (or non-infectious-disease) factors that may cause increase in body temperature or CRP level in inpatients (Table 5 GNR b ), the expression of intrinsic antimicrobial-drugresistance genes encoded in chromosome genes is induced during antimicrobial drug treatment, a phenomenon which is basically rarely seen in E. coli, Klebsiella spp., H. influenzae, and M. catarrhalis (Table 5 GNR a ) ( Table 5) keywords: administration; aspiration pneumonia; bacteria; cases; children; clinical; combination; community; day; days; diagnosis; disease; dose; drip; drug; drug therapy; guidelines; hospital; infection; japan; management; microorganisms; oral; patients; period; pneumonia; pulmonary; risk; severe; society; spp; study; susceptibility; symptoms; therapy; times; treatment; tuberculosis; type cache: cord-275828-c6d6nk7x.txt plain text: cord-275828-c6d6nk7x.txt item: #90 of 196 id: cord-276886-vcmkz8lh author: Mandsberg, Nikolaj Kofoed title: Orally ingestible medical devices for gut engineering date: 2020-05-13 words: 8069 flesch: 39 summary: Microfabricated drug devices incorporate planar geometries with low aspect ratio, together with uni-directional release, as most are sealed from one end (i.e reservoir-like geometry). Challenges associated with gut microenvironment, together with various activation/actuation modalities of medical devices for micromanipulation of the gut are discussed. keywords: capsule; challenges; delivery; design; device; drug; fig; gut; iii; insulin; intestine; microdevices; release; size; stomach; time; tract; vivo cache: cord-276886-vcmkz8lh.txt plain text: cord-276886-vcmkz8lh.txt item: #91 of 196 id: cord-277535-u283k70i author: Vaja, Rakesh title: Drugs and the liver date: 2020-09-22 words: 4015 flesch: 45 summary: Prevalence of ultrarapid metabolisers Metabolism of drugs in liver disease depends on liver blood flow. NSAIDS are contraindicated for systemic use in most liver disease patients, because of increased bioavalibilty, the high risk of precipitating gastrointestinal bleeding and renal failure. keywords: blood; codeine; disease; dose; drugs; failure; liver; metabolism; paracetamol; patients cache: cord-277535-u283k70i.txt plain text: cord-277535-u283k70i.txt item: #92 of 196 id: cord-278362-pwi48i20 author: Khan, Abbas title: Combined drug repurposing and virtual screening strategies with molecular dynamics simulation identified potent inhibitors for SARS-CoV-2 main protease (3CLpro) date: 2020-06-18 words: 5144 flesch: 49 summary: A total of 31 FDA approved anti-HIV drugs, and Traditional Chinese medicines (TCM) database were screened to find potential inhibitors. Literature mining was carried out to collect anti-HIV drugs for screening against 3CLpro (SARS-COV-2). keywords: 3clpro; binding; compounds; coronavirus; cov-2; drugs; energy; hiv; residues; sars cache: cord-278362-pwi48i20.txt plain text: cord-278362-pwi48i20.txt item: #93 of 196 id: cord-279106-3ffa9djf author: Syatila Ab Ghani, Nur title: Side chain similarity comparisons for integrated drug repositioning and potential toxicity assessments in epidemic response scenarios: the case for COVID-19 date: 2020-10-21 words: 6982 flesch: 40 summary: 33 34 3. Results and Discussion 35 In this study, sub-structural similarity searches and docking analyses were carried out to: (i) identify 36 potential targets and drug binding sites in SARS-CoV-2 proteins; (ii) identify off-targets for proposed drug 37 compounds for COVID-19; (iii) identify other approved drugs with similar structure to proposed drugs that 38 are potentially useful for COVID-19 treatment. In this work, the three-dimensional arrangements of amino acid side chains in known drug binding sites (substructures) were used to search for similarly arranged sites in SARS-CoV-2 protein structures in the Protein Data Bank for the potential repositioning of approved compounds. keywords: binding; compounds; cov-2; covid-19; docking; drug; pdbid; potential; protein; sars; similarity; sites; structures; target cache: cord-279106-3ffa9djf.txt plain text: cord-279106-3ffa9djf.txt item: #94 of 196 id: cord-280158-3fhhuzg5 author: Hoffman, Paul S. title: Antibacterial Discovery: 21st Century Challenges date: 2020-04-28 words: 5289 flesch: 34 summary: In retrospect, few searches for new drug targets considered mutation frequency as a criterion for prioritization. Along these lines, developing antimicrobials that target either GP or GN bacteria would exploit new drug targets unique to each, such as teixobactin for GPB. keywords: antibacterial; antibiotic; chemical; development; discovery; drug; mechanisms; mutation; new; resistance; spectrum; targets cache: cord-280158-3fhhuzg5.txt plain text: cord-280158-3fhhuzg5.txt item: #95 of 196 id: cord-280819-z6ucnwk0 author: Achilonu, Ikechukwu title: Targeting the SARS-CoV-2 main protease using FDA-approved Isavuconazonium, a P2-P3 α-ketoamide derivative and Pentagastrin: an in-silico drug discovery approach date: 2020-09-02 words: 5421 flesch: 45 summary: Annual review of biochemistry DrugBank: a knowledgebase for drugs, drug actions and drug targets DrugBank: a comprehensive resource for in silico drug discovery and exploration PubChem substance and compound databases PubChem as a public resource for drug discovery. Proteases are attractive targets in a rational approach to COVID-19 drug discovery. keywords: covid-19; discovery; drug; dynamics; energy; ligand; protease; sars; structure; studies; study cache: cord-280819-z6ucnwk0.txt plain text: cord-280819-z6ucnwk0.txt item: #96 of 196 id: cord-281561-r10y2sgb author: Tiwari, Nidhi title: Novel β-Coronavirus (SARS-CoV-2): Current and Future Aspects of Pharmacological Treatments date: 2020-08-27 words: 6887 flesch: 34 summary: The drugs at present used in COVID-19 patients and ongoing clinical trials focusing on drug repurposing of various therapeutic classes of drug e.g. antiviral, anti-inflammatory and/or immunomodulatory drugs along with adjuvant/supportive care. From this review, our aim is to provide a basic overview about currently available drugsand drugs under clinical trial for COVID-19 patients. keywords: coronavirus; cov-2; covid-19; disease; drug; efficacy; et al; infection; novel; patients; safety; sars; studies; study; treatment cache: cord-281561-r10y2sgb.txt plain text: cord-281561-r10y2sgb.txt item: #97 of 196 id: cord-283287-073r80s7 author: Farhoudian, Ali title: COVID-19 and Substance Use Disorders: Recommendations to a Comprehensive Healthcare Response. An International Society of Addiction Medicine Practice and Policy Interest Group Position Paper date: 2020-04-12 words: 8137 flesch: 34 summary: Additionally PWUDs live in crowded locations and so screening and early identification of COVID-19 patients are important to break the cycle of transmission. The Lancet Chronic cocaine abuse and dilated cardiomyopathy Prize-based contingency management for the treatment of substance abusers: A meta-analysis Voluntary versus prescribed termination of methadone maintenance Opioid substitution treatment planning in a disaster context: Perspectives from emergency management and health professionals in Aotearoa/New Zealand Forensic medicine and toxicology: Drug addiction Management of the opiate abstinence syndrome Opioid substitution treatment planning in a disaster context: Perspectives from emergency management and health professionals in Aotearoa/New Zealand Efavirenz treatment and falsepositive results in benzodiazepine screening tests Understanding links among opioid use, overdose, and suicide At least 44 dead from drinking toxic alcohol in Iran after coronavirus cure rumor Community engagement-the harms of drug prohibition: Ongoing resistance in Vancouver's Downtown Eastside Prevalence and risk factors for unrecognized obstructive lung disease among urban drug users Relapse and relapse prevention Determinants of influenza vaccination in hard-to-reach urban populations A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-March Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study Kidney impairment is associated with in-hospital death of COVID-19 patients. keywords: addiction; buprenorphine; care; coronavirus; covid-19; drug; et al; health; infection; management; methadone; opioid; patients; people; pwud; risk; services; stress; transmission; treatment; use cache: cord-283287-073r80s7.txt plain text: cord-283287-073r80s7.txt item: #98 of 196 id: cord-283956-zgrtux7i author: Amin, Sk. Abdul title: Fight against novel coronavirus: A perspective of medicinal chemists date: 2020-06-12 words: 5115 flesch: 47 summary: SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection Endoribonuclease from SARS CoV-2. The crystal structure of papainlike protease of SARS CoV-2 6W9C Deposited It is a challenging task to identify effective anti-COVID-19 drugs urgently. keywords: anti; binding; coronavirus; cov-2; covid-19; discovery; drug; inhibitors; novel; protein; receptor; sars; screening; structure cache: cord-283956-zgrtux7i.txt plain text: cord-283956-zgrtux7i.txt item: #99 of 196 id: cord-284208-8fsqgkw5 author: Zolla, Lello title: Proteomics studies reveal important information on small molecule therapeutics: a case study on plasma proteins date: 2008-11-07 words: 6995 flesch: 30 summary: HUPO plasma proteome project: challenges and future directions The human proteome organization plasma proteome project pilot phase: reference specimens, technology platform comparisons, and standardized data submissions and analyses Characterization of the human blood plasma proteome Utilizing human blood plasma for proteomic biomarker discovery Oxidation of proteins: basic principles and perspectives for blood proteomics Proteomic analysis of RBC membrane protein degradation during blood storage Composition of the peptide fraction in human blood plasma: database of circulating human peptides Peptide and protein drug delivery to and into tumors: challenges and solutions Effects of genetic engineering on the pharmacokinetics of antibodies Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry Multi-component immunoaffinity subtraction chromatography: an innovative step towards a comprehensive survey of the human plasma proteome Differences among techniques for high-abundant protein depletion Immunoaffinity separation of plasma proteins by IgY microbeads: meeting the needs of proteomic sample preparation and analysis Evaluation of multiprotein immunoaffinity subtraction for plasma proteomics and candidate biomarker discovery using mass spectrometry A novel four-dimensional strategy combining protein and peptide separation methods enables detection of low-abundance proteins in human plasma and serum proteomes Two-dimensional separation of human plasma proteins using iterative free-flow electrophoresis The ProteoMiner in the proteomic arena: a non-depleting tool for discovering low-abundance species Prefractionation, enrichment, desalting and depleting of low volume and low abundance proteins and peptides using the MF10 An investigation into the human serum interactome Protein biomarker discovery and validation: the long and uncertain path to clinical utility Proteomics and disease -the challenges for technology and discovery Clinical proteomics: revolutionizing disease detection and patient tailoring therapy Mining the plasma proteome for cancer biomarkers Strategies for plasma proteomic profiling of cancers Proteomics-driven cancer biomarker discovery: looking to the future Dysregulation of retinoid transporters expression in body fluids of schizophrenia patients Comparative plasma proteome analysis of lymphoma-bearing SJL mice Proteomic characterization of inter-alpha inhibitor proteins from human plasma Proteomic strategies for Individualizing therapy of acute myeloid leukemia (AML) Pharmacogenomics and pharmacoproteomics in the evaluation and management of short stature From genomics to proteomics Mass spectrometry-based proteomics Mass spectrometry-based clinical proteomics Calorimetry outside the box: a new window into the plasma proteome The impact of systems approaches on biological problems in drug discovery Identifying pharmacodynamic protein markers of centrally active drugs in humans: a pilot study in a novel clinical model Alpha cell function in health and disease: influence of glucagon-like peptide-1 Technologies and methods for sample pretreatment in efficient proteome and peptidome analysis Quantitative phosphoproteomic analysis of signaling network dynamics Signaling -2000 and beyond Technology insight: pharmacoproteomics for cancerpromises of patient-tailored medicine using protein microarrays High-content single-cell drug screening with phosphospecific flow cytometry Antibody arrays in cancer research Protein chip technology Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front Progress in protein and antibody In the near future, pharmacoproteomics, the use of proteomic technologies in the field of drug discovery and development, and interactomics, the branch of proteomics which is concerned with identifying interactions between proteins, will allow researchers to (i) know the specific protein changes that occur in biological compartments in response to drug administration; (ii) design small novel therapeutic molecules that can have extended half-lives if carried by plasma protein in the blood stream. keywords: analysis; biomarkers; blood; cell; development; discovery; disease; drug; human; interactions; interactome; peptides; plasma; proteins; proteome; proteomic cache: cord-284208-8fsqgkw5.txt plain text: cord-284208-8fsqgkw5.txt item: #100 of 196 id: cord-284479-75zgljet author: García-Serradilla, Moisés title: Drug repurposing for new, efficient, broad spectrum antivirals date: 2019-04-15 words: 7588 flesch: 29 summary: Although it seems to act at several steps of the viral life cycle, the isomerase activity of CypA does not seem to be implicated (Liu et al., 2009) . Overexpression of CypA inhibits M1 translocation into the nucleus (Liu et al., 2009 ) while depletion of CypA accelerated the replication of the virus (Liu et al., 2012b) . keywords: activity; cell; chloroquine; drug; effect; et al; hepatitis; human; infection; influenza; new; replication; studies; treatment; virus; viruses cache: cord-284479-75zgljet.txt plain text: cord-284479-75zgljet.txt item: #101 of 196 id: cord-284648-yznlgzir author: Varanko, Anastasia title: Recent trends in protein and peptide-based biomaterials for advanced drug delivery date: 2020-08-29 words: 33598 flesch: 36 summary: As researchers continue to make progress in adapting existing and developing new protein materials, there is also great opportunity for biological and materials science research that will maximize the clinical success of protein drug carriers. OVA was originally chosen as a carrier for drug delivery because of its availability, low cost, ability to form gel networks and stabilize emulsions and foams, and pH-and temperature-sensitive properties [128] . keywords: acid; albumin; applications; assembly; binding; cancer; cell; collagen; crosslinking; delivery; dox; drug; drug delivery; elastin; elp; figure; fold; fusion; gelatin; growth; half; helix; human; hydrogel; hydrophobic; keratin; life; materials; model; nanoparticles; peptide; phase; polypeptide; properties; protein; r n; release; residues; self; sequence; serum; silk; stability; structure; study; temperature; therapeutic; transferrin; tumor; u r; vivo; zein cache: cord-284648-yznlgzir.txt plain text: cord-284648-yznlgzir.txt item: #102 of 196 id: cord-285121-3cjr1rol author: Chan, Marion M. title: Targeting cancer stem cells with dietary phytochemical - Repositioned drug combinations date: 2018-10-01 words: 8624 flesch: 40 summary: Designing a broad-spectrum integrative approach for cancer prevention and treatment Hallmarks of cancer: the next generation Tumorigenesis: it takes a village Cancer stem cells-perspectives on current status and future directions: AACR workshop on cancer stem cells Dietary phytochemicals target cancer stem cells for cancer chemoprevention Existing drugs and their application in drug discovery targeting cancer stem cells Inhibition of growth and sensitization to cisplatin-mediated killing of ovarian cancer cells by polyphenolic chemopreventive agents Epigallocatechin-3-gallate delivers hydrogen peroxide to induce death of ovarian cancer cells and enhances their cisplatin susceptibility Mechanisms of combined action of different chemopreventive dietary compounds: a review Promiscuous drugs compared to selective drugs (promiscuity can be a virtue) Commentary: novel therapies for cancer: why dirty might be better Cancer stem cells: an evolving concept Cancer stem cells: basic concepts and therapeutic implications Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis Tumourinitiating cells: challenges and opportunities for anticancer drug discovery Targeting cancer stem cells to suppress acquired chemotherapy resistance Cancer stem cells (CSCs) in drug resistance and their therapeutic implications in cancer treatment Chemical approaches to targeting drug resistance in cancer stem cells Concise review: stem cells and epithelialmesenchymal transition in cancer: biological implications and therapeutic targets Aldehyde dehydrogenases and cancer stem cells Cancer stem cell definitions and terminology: the devil is in the details Eyes wide open: a critical review of sphere-formation as an assay for stem cells Targeting cancer stem cells with defined compounds and drugs The use of natural products to target cancer stem cells Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds Cancer chemoprevention with dietary phytochemicals Overcoming drug resistance by phytochemicals Dietary intervention by phytochemicals and their role in modulating coding and noncoding genes in cancer Targeting cancer stem cells with phytochemicals Novel strategies targeting cancer stem cells through phytochemicals and their analogs Phytochemicals as innovative therapeutic tools against cancer stem cells Therapeutic effectiveness of anticancer phytochemicals on cancer stem cells Emerging importance of dietary phytochemicals in fight against cancer: role in targeting cancer stem cells Cancer stem cells: potential target for bioactive food components In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties New insights into therapeutic activity and anticancer properties of curcumin The role of cancer stem cells in the anti-carcinogenicity of curcumin Targeting cancer stem cells by curcumin and clinical applications Curcumin and cancer stem cells: curcumin has asymmetrical effects on cancer and normal stem cells Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy Curcumin suppresses phthalate-induced metastasis and the proportion of cancer stem cell (CSC)-like cells via the inhibition of AhR/ERK/SK1 signaling in hepatocellular carcinoma Curcumin induces cell death in esophageal cancer cells through modulating notch signaling The functional genomic studies of curcumin Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines Curcumin inhibits the side population (SP) phenotype of the rat C6 glioma cell line: towards targeting of cancer stem cells with phytochemicals Curcumin improves the tumoricidal effect of mitomycin C by suppressing ABCG2 expression in stem celllike breast cancer cells Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: potential role of EMT The pharmacology of resveratrol in animals and humans key: cord-285121-3cjr1rol authors: Chan, Marion M.; Chen, Rensa; Fong, Dunne title: Targeting cancer stem cells with dietary phytochemical - Repositioned drug combinations date: 2018-10-01 journal: Cancer Lett DOI: 10.1016/j.canlet.2018.06.034 sha: doc_id: 285121 cord_uid: 3cjr1rol keywords: anti; breast; cancer; cancer stem; cells; combination; cscs; curcumin; drug; effects; egcg; genistein; inhibition; metformin; phytochemicals; resveratrol; stem; stem cells; targeting; targets; therapy; tumor cache: cord-285121-3cjr1rol.txt plain text: cord-285121-3cjr1rol.txt item: #103 of 196 id: cord-285603-f4572w5m author: Ortega, Joseph T. title: Class A G Protein-Coupled Receptor Antagonist Famotidine as a Therapeutic Alternative against SARS-CoV2: An In Silico Analysis date: 2020-06-24 words: 5999 flesch: 42 summary: However, weak binding affinity of famotidine to these proteases suggests that a successful famotidine therapy could likely be achieved only in combination with other antiviral drugs. Thus, it seems that, similarly to ribavirin, the best therapeutic effect of famotidine could be achieved in combination therapy with other antiviral drugs [64, 65] . keywords: analysis; binding; cov2; drugs; famotidine; hiv; inhibitors; lopinavir; protease; replication; sars; viral cache: cord-285603-f4572w5m.txt plain text: cord-285603-f4572w5m.txt item: #104 of 196 id: cord-287758-da11ypiy author: Mônica Vitalino de Almeida, Sinara title: COVID-19 therapy: what weapons do we bring into battle? date: 2020-09-10 words: 17493 flesch: 35 summary: More preclinical and clinical studies are required to prove whether dasatinib is really promising for COVID-19 patient treatment. SBV is also combined with other antiviral drugs, such as ledipasvir, velpatasvir and voxilaprevir. keywords: action; activity; antiviral; binding; cells; clinical; coronavirus; cov-2; covid-19; disease; drug; entry; fig; host; human; infection; inhibitor; mechanism; new; novel; patients; potential; pro; protein; receptor; replication; results; rna; sars; studies; study; syndrome; synthesis; targets; therapy; treatment cache: cord-287758-da11ypiy.txt plain text: cord-287758-da11ypiy.txt item: #105 of 196 id: cord-288026-vcp8o5xn author: DeStefano, Vincent title: Applications of PLA in Modern Medicine date: 2020-09-06 words: 8596 flesch: 40 summary: Due to its adaptable degradation rate, PLA scaffolds offer a highly desirable feature for drug delivery systems: long-term drug release. Inadequate reactivity in the pores of PLA scaffolds may fail to promote cell ingress and may also need an autograft to see scaffolds. keywords: acid; applications; bone; cell; degradation; delivery; drug; pla; polymer; printing; properties; rate; result; scaffolds; strength; tissue; weight cache: cord-288026-vcp8o5xn.txt plain text: cord-288026-vcp8o5xn.txt item: #106 of 196 id: cord-289321-ahl46ql9 author: van Buuren, Nicholas title: Transmission genetics of drug-resistant hepatitis C virus date: 2018-03-28 words: 7846 flesch: 42 summary: Finally, the cis-dominance of Daclatasvir-resistant WT-Y93H was observed when coinfected with drug susceptible virus (S) in the absence and presence of Daclatasvir ( Figure 4H ). A Novel RNA ISH Multicolor Application for Flow Cytometry Efficient rescue of hepatitis C virus RNA replication by transcomplementation with nonstructural protein 5A Boceprevir for previously treated chronic HCV genotype 1 infection Kinetic and structural analyses of hepatitis C virus polyprotein processing Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication Permissive secondary mutations enable the evolution of influenza oseltamivir resistance Daclatasvir Prevents Hepatitis C Virus Infectivity by Blocking Transfer of the Viral Genome to Assembly Sites The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturation Complete three-dimensional structures of picornaviral RNA-dependent RNA polymerases Trans-dominant inhibition of RNA viral replication can slow growth of drugresistant viruses Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance Daclatasvir plus sofosbuvir for HCV infection General catalytic deficiency of hepatitis C virus RNA polymerase with an S282T mutation and mutually exclusive resistance towards 2'-modified nucleotide van Oral direct-acting agent therapy for hepatitis c virus infection: a systematic review Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin Combining oncolytic virotherapy and cytotoxic therapies to fight cancer Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052 Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect Antiviral activity and resistance of HCV NS5A replication complex inhibitors HCV NS5A replication complex inhibitors Dominant negative effect of wild-type NS5A on NS5A-adapted subgenomic hepatitis C virus RNA replicon Virus mutation frequencies can be greatly underestimated by monoclonal antibody neutralization of virions Telaprevir for previously untreated chronic hepatitis C virus infection Cell culture and infection system for hepatitis C virus Hepatitis C virus RNA replication depends on specific cis-and trans-acting activities of viral nonstructural proteins Origins of combination therapy for tuberculosis: lessons for future antimicrobial development and application My cousin, my enemy: quasispecies suppression of drug resistance Ná jera I. 2006. keywords: cells; drug; et al; figure; genomes; hcv; hepatitis; ns3/4a; ns5a; replication; resistance; rna; virus; viruses cache: cord-289321-ahl46ql9.txt plain text: cord-289321-ahl46ql9.txt item: #107 of 196 id: cord-289382-bnl9i9oy author: Wright, Gerard D title: Q&A: Antibiotic resistance: where does it come from and what can we do about it? date: 2010-09-20 words: 3362 flesch: 31 summary: The prevalence and mobility of resistance genes in previously sensitive pathogenic bacteria has now reached crisis levels in many cases because new antibiotics are no longer being developed at a rate that can keep pace with microbial evolution. There are a number of reasons, some economic, for the paucity of new antibiotics. keywords: antibiotics; bacteria; cell; drug; genes; resistance; synthetic; use cache: cord-289382-bnl9i9oy.txt plain text: cord-289382-bnl9i9oy.txt item: #108 of 196 id: cord-291180-xurmzmwj author: Lin, Xiaoqian title: A Review on Applications of Computational Methods in Drug Screening and Design date: 2020-03-18 words: 7739 flesch: 35 summary: With the assembly of reasonable molecular fragments, the objective of drug design method is to produce a certain novel molecule that display highest biological activity, absorption, metabolism, elimination (ADME) and lowest toxicity properties at different environments, which belong to the application range of QSAR models. Different drug design methods and virtual screening will be very useful to design and find rational drug molecules based on the target macromolecule that interacts with the drug and thus speed up the whole drug discovery process. keywords: activity; data; design; development; discovery; drug; learning; methods; model; modeling; molecules; multiscale; protein; qsar; screening; structure; target cache: cord-291180-xurmzmwj.txt plain text: cord-291180-xurmzmwj.txt item: #109 of 196 id: cord-292041-a65kfw80 author: Orienti, Isabella title: Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment in COVID-19 date: 2020-05-27 words: 6133 flesch: 29 summary: Pulmonary formulations of anti-inflammatory drugs could represent a good option in combination with systemic antiviral drugs or glucocorticoids. It decreased the infiltration of inflammatory cells and inhibited the production of inflammatory cytokines [84] . keywords: activity; cells; cov; cov-2; covid-19; drugs; fenretinide; infection; lung; pulmonary; response; sars; treatment; virus cache: cord-292041-a65kfw80.txt plain text: cord-292041-a65kfw80.txt item: #110 of 196 id: cord-293860-6kz0iws6 author: Qutayba Almerie, Muhammad title: The Association between Obesity and Poor Outcome after COVID-19 Indicates a Potential Therapeutic Role for Montelukast date: 2020-05-27 words: 2804 flesch: 31 summary: Evidence supporting montelukast as a candidate COVID-19 therapy in individuals with obesity: Patients affected by severe obesity share a common physiological response with patients with COVID-19 as both have raised concentrations of pro-inflammatory cytokines (e.g., TNF-a, IL1 and IL6) and T-helper-2 cytokines (IL4, IL10) Regulation of adipose tissue inflammation by interleukin 6 Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters Inflammatory cytokines in general and central obesity and modulating effects of physical activity Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol Are more black, Asian and minority ethnic people dying with Covid-19 than might be expected? keywords: covid-19; drugs; immune; montelukast; obesity; patients; response cache: cord-293860-6kz0iws6.txt plain text: cord-293860-6kz0iws6.txt item: #111 of 196 id: cord-294582-flkjekyo author: Hijikata, Atsushi title: Knowledge‐based structural models of SARS‐CoV‐2 proteins and their complexes with potential drugs date: 2020-05-25 words: 4257 flesch: 43 summary: Also, the structural models of the complexes between SARS-CoV-2 proteins and potential drugs were proposed by comparing the ligand molecules of the proteins and approved, experimental, or natural drugs. COMPLIG matches molecular graphs and evaluates the similarity score of two molecules A and B as min{M Selected drug molecules were built into the protein models by superposing drug molecules to known (original) ligand molecules with COMPLIG. keywords: ace2; complex; coronavirus; drugs; ligand; models; molecules; proteins; rna; sars; structure cache: cord-294582-flkjekyo.txt plain text: cord-294582-flkjekyo.txt item: #112 of 196 id: cord-295807-68sukdb1 author: Quade, Bianca N. title: The therapeutic importance of acid-base balance date: 2020-10-09 words: 20817 flesch: 36 summary: The direct secretion of these drugs into the nephron lumen is necessary because many such drugs are substantially bound to albumin in circulation and are not effectively filtered into the nephron lumen at the glomerulus. Numerous acid-base handling proteins are upregulated in rapidly proliferating tumor calls to help them dispose of metabolic acids and create an acidic microenvironment that disadvantages non-tumor cells in their vicinity. keywords: abts; acid; acidosis; action; balance; base; bicarbonate; blood; cancer; cells; cftr; chronic; co2; disease; drug; effect; example; fluid; hco3; influence; kidney; load; mac; metabolic; mice; nahco3; patients; potential; renal; response; role; salivary; secretion; section; sodium; study; system; therapy; treatment; tumor cache: cord-295807-68sukdb1.txt plain text: cord-295807-68sukdb1.txt item: #113 of 196 id: cord-297010-imciixde author: Babayeva, Mariana title: Repurposing Drugs for COVID-19: Pharmacokinetics and Pharmacogenomics of Chloroquine and Hydroxychloroquine date: 2020-10-23 words: 7101 flesch: 43 summary: Another open-label non-randomized clinical trial with 36 COVID-19 patients demonstrated that hydroxychloroquine treatment resulted in viral load reduction/disappearance in the patients. Mechanisms underlying variability in drug concentrations and therapeutic response with chloroquine and hydroxychloroquine in mediating beneficial and adverse effects of chloroquine and hydroxychloroquine were reviewed and analyzed. keywords: chloroquine; concentrations; covid-19; cyp2c8; dose; drug; hcq; hydroxychloroquine; malaria; medications; metabolism; patients; plasma; treatment cache: cord-297010-imciixde.txt plain text: cord-297010-imciixde.txt item: #114 of 196 id: cord-298033-kzdp9edn author: Domingo, Esteban title: Quasispecies dynamics in disease prevention and control date: 2019-11-08 words: 16379 flesch: 29 summary: Drug ReposER: a web server for predicting similar amino acid arrangements to know drug binding interfaces for potential drug repositioning Involvement of a joker mutation in a polymerase-independent lethal mutagenesis escape mechanism Amantadine-resistance as a genetic marker for influenza viruses HIV Nef: role in pathogenesis and viral fitness Mechanisms of HIV-1 escape from immune responses and antiretroviral drugs Estimating HIV evolutionary pathways and the genetic barrier to drug resistance Genetic basis of resistance to rimantadine emerging during treatment of influenza virus infection Influenza: The Last Great Plague; and Unfinished Story of Discovery The Vaccine Book Transmitted/founder viruses rapidly escape from CD8 þ T cell responses in acute hepatitis C virus infection Natural History of Infections Disease Epitope-specific CD8 þ T lymphocytes cross-recognize mutant simian immunodeficiency virus (SIV) sequences but fail to contain very early evolution and eventual fixation of epitope escape mutations during SIV infection Two escape mechanisms of influenza a virus to a broadly neutralizing stalk-binding antibody Development of live-attenuated arenavirus vaccines based on codon deoptimization Immunological responses following administration of a genotype 1a/1b/2/3a quadrivalent HCV VLP vaccine The poliovirus eradication initiative Viral persistence in vivo through selection of neutralizing antibody-escape variants CD4þ T-cell-epitope escape mutant virus selected in vivo Perspectives and opportunities for novel antiviral treatments targeting virus fitness Human immunodeficiency virus type 1 fitness and tropism: concept, quantification, and clinical relevance HIV-1 drug resistance and resistance testing Antigenic determinants of possible vaccine escape by porcine circovirus subtype 2b viruses Trans-dominant inhibition of RNA viral replication can slow growth of drugresistant viruses Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient Vaccine development: from concept to early clinical testing Molecular and functional bases of selection against a mutation bias in an RNA virus Molecular epidemiology of hepatitis B virus mutants associated with vaccine escape, drug resistance and diagnosis failure Patterns of resistanceassociated substitutions in patients with chronic HCV infection following treatment with direct-acting antivirals Multiclass HCV resistance to direct-acting antiviral failure in real-life patients advocates for tailored secondline therapies RNA virus evolution and the control of viral disease Complications of RNA heterogeneity for the engineering of virus vaccines and antiviral agents Quasispecies dynamics in disease prevention and control Quasispecies and RNA Virus Evolution: Principles and Consequences Virus population dynamics, fitness variations and the control of viral disease: an update Viral quasispecies evolution. Higher levels of resistance mutations as a function of time in untreated patients is an indication that the mutations are not due to basal mutant frequencies but to the epidemiological expansion of virus mutants that originated in treated patients. keywords: antigenic; antiviral; cell; chapter; disease; drug; drug resistance; dynamics; escape; et al; fitness; frequency; hepatitis; infection; inhibitor; mutants; mutations; population; replication; resistance; resistance mutations; section; selection; treatment; vaccine; virus; viruses cache: cord-298033-kzdp9edn.txt plain text: cord-298033-kzdp9edn.txt item: #115 of 196 id: cord-298369-66ifwtlp author: Smith, Sherri A. title: Pharmacokinetic and Pharmacodynamic Considerations for Drugs Binding to Alpha-1-Acid Glycoprotein date: 2018-12-28 words: 10732 flesch: 37 summary: In human AAG levels are lower in the pregnant female and continue to decline throughout pregnancy until birth when they begin to climb back to pre-pregnancy values (53, 56, 57) . In the chronic, accelerated, and blast crisis phases of disease, 33, 83 and 75% of these patients, respectively, were increasingly likely to have higher AAG levels. keywords: aag; acid; affinity; albumin; alpha; binding; blood; drug; fold; free; glycoprotein; high; human; levels; plasma; serum; species; vismodegib cache: cord-298369-66ifwtlp.txt plain text: cord-298369-66ifwtlp.txt item: #116 of 196 id: cord-299225-exbdg3x9 author: Guarnieri, Michael title: A Long-Term Study of a Lipid-Buprenorphine Implant in Rats date: 2018-07-09 words: 2670 flesch: 45 summary: Female rats were chosen for a long-term trial because female rats may have increased susceptibility to opiates [22] , although sex differences have not been fully determined. Voluntary ingestion of nut paste for administration of buprenorphine in rats and mice Oral self-administration of buprenorphine in the diet for analgesia in mice New developments in long-acting injectable nanoformulations Local delivery of rapamycin: a toxicity and efficacy study in an experimental malignant glioma model in rats Brain biocompatibility of a biodegradable, controlledrelease polymer in rats Pharmacokinetic comparison of sustained-release and standard buprenorphine in mice Duration of action of sustained-release buprenorphine in 2 strains of mice Evaluation of a sustained-release formulation of buprenorphine for analgesia in rats Safety and clinical effectiveness of a compounded sustained-release formulation of buprenorphine for postoperative analgesia in New Zealand white rabbits Clinical efficacy of sustained-release buprenorphine with meloxicam for postoperative analgesia in Beagle dogs undergoing ovariohysterectomy Pharmacokinetics of 2 formulations of buprenorphine in macaques (macaca mulatta and macaca fascicularis) Engineering solid lipid nanoparticles for improved drug delivery: promises and challenges of translational research Cholesterol matrix delivery system for sustained release of macromolecules Prolonged analgesia and decreased toxicity with liposomal morphine in a mouse model Pharmacokinetics of ammonium sulfate gradient loaded liposome-encapsulated oxymorphone and hydromorphone in healthy dogs A long-acting buprenorphine delivery system Subcutaneous implants for long-acting drug therapy in laboratory animals may generate unintended drug reservoirs Thermal latency studies in opiate-treated mice Subcutaneous Implants of Buprenorphine-Cholesterol-Triglyceride Powder in Mice Safety studies of post-surgical buprenorphine therapy for mice Subcutaneous Implants of a Cholesterol-Triglyceride-Buprenorphine Suspension in Rats Sex differences in opioid antinociception Unanticipated Adverse Events Associated with an Extended-Release Buprenorphine Toxicity Study in Fischer 344 Rats Opioid-induced emesis among hospitalized nonsurgical patients: effects on pain and quality of life Pica behavior associated with buprenorphine administration in the rat Pica behavior associated with buprenorphine administration in the rat Adverse effects on growth rates in rats caused by buprenorphine administration Correlation between body weight changes and postoperative pain in rats treated with meloxicam or buprenorphine Influence of buprenorphine analgesia on post-operative recovery in two strains of rats Funding for this research was supplied by The Maryland Biotechnology Center Biotechnology Development Awards, Maryland Industrial Partnerships (MIPS), and by Animalgesic Labs. keywords: animals; buprenorphine; control; dose; drug; group; rats cache: cord-299225-exbdg3x9.txt plain text: cord-299225-exbdg3x9.txt item: #117 of 196 id: cord-299400-j18pj11d author: Norinder, Ulf title: Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19 date: 2020-07-30 words: 5312 flesch: 26 summary: Even though the database is logically enriched in antiviral drugs, there are more than 20 CADs registered for various non-viral indications listed in the database with collected evidence of their broad antiviral activity in vitro, in vivo and in clinical studies, including activities on coronaviruses, influenza, zika and ebola virus. Incidence and prognosis Arbidol: a broad-spectrum antiviral compound that blocks viral fusion Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia Pharmacokinetic/pharmacodynamic modeling of the antiretroviral activity of the CCR5 antagonist Vicriviroc in treatment experienced HIV-infected subjects (ACTG protocol 5211) Approved Antiviral Drugs over the Past 50 Years Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man Clinical pharmacokinetics and metabolism of chloroquine. keywords: accumulation; activity; antiviral; cads; compounds; drugs; effects; et al; lysosomotropic; membrane; phospholipidosis cache: cord-299400-j18pj11d.txt plain text: cord-299400-j18pj11d.txt item: #118 of 196 id: cord-299424-qy3lccjq author: MUBAGWA, Kanigula title: Chloroquine cardiac effects and toxicity.A short update. date: 2020-06-19 words: 8958 flesch: 37 summary: In addition, at high chloroquine concentrations loss of excitability and suppressed conduction (due to chloroquine effects on the upstroke of the action potential) might account for an apparent loss of contraction. The mechanisms underlying chloroquine effects include direct actions on ion channels and receptors, while others (especially a cardiomyopathy developing following long-term treatment) involve the inhibition of autophagy. keywords: action; autophagy; cardiac; channels; chloroquine; drugs; effects; heart; hydroxychloroquine; inhibition; potential; remodeling cache: cord-299424-qy3lccjq.txt plain text: cord-299424-qy3lccjq.txt item: #119 of 196 id: cord-299911-v95pf3eg author: El-Ghiaty, Mahmoud A. title: Cytochrome P450-mediated drug interactions in COVID-19 patients: current findings and possible mechanisms date: 2020-06-26 words: 5332 flesch: 31 summary: IL-1 beta counteracts clofibric acid induction of CYP4A in cultured fetal rat hepatocytes Suppression of CYP2C11 gene transcription by interleukin-1 mediated by NF-kappaB binding at the transcription start site Effects of interleukin 1beta (IL-1beta) and IL-1beta/interleukin 6 (IL-6) combinations on drug metabolizing enzymes in human hepatocyte culture Pretranslational down-regulation of cytochromes P450 2C11 and 3A2 in male rat liver by tumor necrosis factor alpha Nitric oxidemediated inhibition of cytochrome P450 by interferon-gamma in human hepatocytes inactivation by serum from humans with a viral infection and serum from rabbits with a turpentine-induced inflammation: the role of cytokines The interleukin-2 receptor downregulates the expression of cytochrome P450 in cultured rat hepatocytes Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy In vivo effects of interleukin-10 on human cytochrome P450 activity Down-regulation of the hepatic cytochrome P450 by an acute inflammatory reaction: implication of mediators in human and animal serum and in the liver Cytochrome P450 down-regulation by serum from humans with a viral infection and from rabbits with an inflammatory reaction Effect of interleukin 6 on phenobarbital induction of cytochrome P-450IIB in cultured rat hepatocytes Chauvelot-Moachon L. Effects of interleukin-6 on cytochrome P450-dependent mixed-function oxidases in the rat Interleukin-6 down regulates the expression of transcripts encoding cytochrome P450 IA1, IA2 and IIIA3 in human hepatoma cells Suppression of constitutive cytochrome P-450 gene expression in livers of rats undergoing an acute phase response to endotoxin Selective suppression of cytochrome P-450 gene expression by interleukins 1 and 6 in rat liver Suppression of the constitutive expression of cytochrome P-450 2C11 by cytokines and interferons in primary cultures of rat hepatocytes: comparison with induction of acute-phase genes and demonstration that CYP2C11 promoter sequences are involved in the suppressive response to interleukins 1 and 6 Hepatic cytochrome P450 down-regulation during aseptic inflammation in the mouse is interleukin 6 dependent Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver Modulation of hepatic cytochrome P450s by Citrobacter rodentium infection in interleukin-6-and interferon-{gamma}-null mice Cytochrome P450 and antioxidant activity in interleukin-6 knockout mice after induction of the acute-phase response Transgenic mouse models of human CYP3A4 gene regulation Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer Downregulation of drug transport and metabolism in mice bearing extra-hepatic malignancies Extrahepatic cancer represses hepatic drug metabolism via interleukin (IL)-6 signalling Effects of cytokines on CYP3A4 expression and reversal of the effects by anti-cytokine agents in the three-dimensionally cultured human hepatoma cell line FLC-4 Effects of interleukin-6 (IL-6) and an anti-IL-6 monoclonal antibody on drug-metabolizing enzymes in human hepatocyte culture Gene transcription in hepatocytes during the acute phase of a systemic inflammation: from transcription factors to target genes Regulation of cytochrome p450 by inflammatory mediators: why and how? NF-kappaB and the immune response Role of NF-kappaB in the regulation of cytochrome P450 enzymes Mechanism of suppression of cytochrome P-450 1A1 expression by tumor necrosis factor-alpha and lipopolysaccharide Ah receptor and NF-kappaB interactions: mechanisms and physiological implications Modulation of CYP1A2 and CYP3A6 catalytic activities by serum from rabbits with a turpentine-induced inflammatory reaction and interleukin 6 Inhibition of nuclear factor-kappaB signal by pyrrolidine dithiocarbamate alleviates lipopolysaccharide-induced acute lung injury Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes Is nuclear factor kappa-B the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer? = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection Liver injury in COVID-19: management and challenges COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies COVID-19 and liver disease Systemic viral infections and collateral damage in the liver Kupffer cell-dependent hepatitis occurs during influenza infection Liver involvement during influenza infection: perspective on the 2009 influenza pandemic Complex Drug-Drug Interactions Involving Cytochromes P450: Systematic Review of Published Case Reports and Clinical Perspectives Trends in new drug interactions for pharmaceutical products in Japan Infection and inflammation leading to clozapine toxicity and intensive care: a case series Decreased dromotropic response to verapamil despite pronounced increased drug concentration in rheumatoid arthritis Influence of chronic hepatitis C infection on cytochrome P450 3A4 activity using midazolam as an in vivo probe substrate Drug-disease interaction: Crohn's disease elevates verapamil plasma concentrations but reduces response to the drug proportional to disease activity Variability in drug metabolizing enzyme activity in HIV-infected patients Altered theophylline clearance during an influenza B outbreak The use of imipramine in depressed patients with congestive heart failure Understanding Disease-Drug Interactions in Cancer Patients: Implications for Dosing Within the Therapeutic Window Disease-drug-drug interaction involving tocilizumab and simvastatin in patients with rheumatoid arthritis Disease-Drug Interaction of Sarilumab and Simvastatin in Patients with Rheumatoid Arthritis Evaluation of disease-mediated therapeutic protein-drug interactions between an anti-lnterleukin-6 monoclonal antibody (Sirukumab) and cytochrome P450 activities in a phase I study in patients with rheumatoid arthritis using a cocktail approach A physiologically based pharmacokinetic modeling approach to predict disease-drug interactions: suppression of CYP3A by IL-6 Development of a Physiologically Based Pharmacokinetic Model to Predict Disease-Mediated Therapeutic Protein-Drug Interactions: Modulation of Multiple Cytochrome Physiologically Based Pharmacokinetic Model to Assess the Influence of Blinatumomab-Mediated Cytokine Elevations on Cytochrome P450 Enzyme Activity Summary on compassionate use of Remdesivir Gilead Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing Ndesethylchloroquine formation Colchicine--Update on mechanisms of action and therapeutic uses Critical Care Utilization for the COVID-19 Early Experience and Forecast During an Emergency Response Forecasting COVID-19 impact on hospital bed-days, ICU-days, ventilator-days and deaths by US state in the next 4 months Drug-associated disease: cytochrome P450 interactions Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region Clinical implications from drug-drug and drug-disease interactions in older people An update on the clinical consequences of polypharmacy in older adults: a narrative review keywords: activity; covid-19; cyps; cytochrome; disease; drug; expression; hepatic; il-6; liver; p450; patients; response cache: cord-299911-v95pf3eg.txt plain text: cord-299911-v95pf3eg.txt item: #120 of 196 id: cord-301026-spgidqh3 author: Das, Shaoli title: In silico Drug Repurposing to combat COVID-19 based on Pharmacogenomics of Patient Transcriptomic Data date: 2020-06-30 words: 4202 flesch: 34 summary: Using the drug perturbational data sets from CMAP 14 , we found the drugs that affected the gene expression of these targets (differences in gene expression at 24 hours vs. 6 hours of drug treatment). The drug perturbational data set containing dose-and time-dependent transcriptomic pro les upon drug treatments in human cell lines was collected from CMAP 14 . keywords: cell; covid-19; data; drugs; infection; pathways; patients; sars; transcriptomic cache: cord-301026-spgidqh3.txt plain text: cord-301026-spgidqh3.txt item: #121 of 196 id: cord-302018-3rlya16w author: Castells, Mariana C. title: Drug allergy labeling and delabeling in the coronavirus disease 2019 era: What is important and what do we need to know date: 2020-05-22 words: 1939 flesch: 29 summary: Understanding the mechanisms of drug allergy 6 is key, given that the classification of drug hypersensitivity continues to expand. The timing of this issue of the Annals is highly relevant given that it is dedicated to broadening our understanding of the scope of drug allergy in the general population. keywords: allergy; delabeling; drug; patients; penicillin; risk cache: cord-302018-3rlya16w.txt plain text: cord-302018-3rlya16w.txt item: #122 of 196 id: cord-302312-1pm17l5d author: Quinteros, Daniela A. title: Therapeutic use of monoclonal antibodies: general aspects and challenges for drug delivery date: 2017-03-31 words: 10880 flesch: 25 summary: In this chapter we have attempted to identify the major issues associated with therapeutic approaches, formulating drawbacks and delivering antibody drugs, particularly focused on the challenges and opportunities that these present for the future. perils and promise of development The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease Reshaping human antibodies for therapy Molecular clocks Ranibizumab for neovascular age-related macular degeneration Anti-CD166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers Treating metastatic cancer with nanotechnology Nanotechnology in drug delivery and tissue engineering: from discovery to applications Self-assembled targeted nanoparticles: evolution of technologies and bench to bedside translation The high costs of cancer drugs and what we can do about it Rationale for trastuzumab (Herceptin) in adjuvant breast cancer trials Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases Real-time vital optical imaging of precancer using anti-epider mal growth factor receptor antibodies conjugated to gold nanoparticles Investigation of stability and cellular uptake of self associated monoclonal antibody (MAb) nanoparticles by non-small lung cancer cells In vitro and in vivo platelet targeting by cyclic RGD-modified liposomes EB virus-induced B lymphocyte cell lines producing specific antibody Multifunctional poly (D,L-lactide-co-glycolide)/montmorillonite (PLGA/MMT) nanoparticles decorated by Trastuzumab for targeted chemotherapy of breast cancer Nanotechnology in cancer drug delivery and selective targeting review Dendrimers as versatile platform in drug delivery applications Development of functionalized fluorescent europium nanoparticles for biolabeling and time-resolved fluorometric applications Imaging of multiple mRNA targets using quantum dot based in situ hybridization and spectral deconvolution in clinical biopsies Folatetargeted nanoparticles show efficacy in the treatment of inflammatory arthritis keywords: agents; antibodies; antibody; applications; cancer; cells; delivery; detection; development; diagnosis; diseases; drug; efficacy; et al; her2; imaging; mabs; nanoparticles; nanotechnology; surface; targeting; therapy; treatment; tumor; vivo cache: cord-302312-1pm17l5d.txt plain text: cord-302312-1pm17l5d.txt item: #123 of 196 id: cord-302947-flgwxc57 author: Kipshidze, Nicholas title: Targeted, Site-Specific, Delivery Vehicles of Therapeutics for COVID-19 Patients. Brief Review date: 2020-09-16 words: 2143 flesch: 26 summary: Targeted drug delivery of these promising pharmaceuticals might prove to be more effective, enhancing the local effect while attenuating their off-target side effects. 6-10 In the following, some of the newer approaches for targeted drug delivery in COVID-19 patients are discussed. keywords: approach; covid-19; delivery; drug; effects; patients cache: cord-302947-flgwxc57.txt plain text: cord-302947-flgwxc57.txt item: #124 of 196 id: cord-303089-fbxtj8ij author: Boccaletti, Valeria title: Acute generalized exanthematous pustulosis following paracetamol ingestion in a child date: 2015-05-24 words: 959 flesch: 36 summary: Acute generalized exanthematous pustulosis in children Acute generalised exanthematous pustulosis Acute generalized exanthematous pustulosis (AGEP) -a clinical reaction pattern Acute generalized exanthematous pustulosis Mercury-induced acute generalized exanthematous pustulosis misdiagnosed as a drug-related case Cutaneous adverse drug reactions are not always drug-induced A multicenter study to determine the value and safety of drug patch tests for three main classes of severe cutaneous adverse drug reactions Acute generalized exanthematous pustulosis induced by paroxetine in an adolescent girl The histopathological spectrum of acute generalized exanthematous pustulosis (AGEP) and its differentiation from generalized pustular psoriasis A broad range of cutaneous diseases causes pustular reactions such as bacterial folliculitis, subcorneal pustular dermatosis (Sneddon-Wilkinson disease), immunoglobulin A pemphigus, toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) (8), but AGEP is a separate entity and must be distinguished especially from generalized pustular psoriasis (Von Zumbusch type): abrupt onset, rapid course, and spontaneous healing as the culprit drug is stopped together with non-recurrence and absence of personal and family history of psoriasis may help. keywords: agep; drug; paracetamol; pustulosis cache: cord-303089-fbxtj8ij.txt plain text: cord-303089-fbxtj8ij.txt item: #125 of 196 id: cord-303237-xvba5mqq author: Wang, L.-Y. title: Genetic Profiles in Pharmacogenes Indicate Personalized Drug Therapy for COVID-19 date: 2020-03-30 words: 4464 flesch: 54 summary: They could be the explanation of individual and ethnic difference for COVID-19 drug treatment. It is noteworthy that the individual difference of drug treatment is mentioned for a special in the guideline. keywords: covid-19; drugs; figure; license; medrxiv; mutations; perpetuity; preprint; treatment cache: cord-303237-xvba5mqq.txt plain text: cord-303237-xvba5mqq.txt item: #126 of 196 id: cord-303555-mwu72q7w author: Dent, Paul title: Cell Signaling and Translational Developmental Therapeutics date: 2020-10-06 words: 8900 flesch: 37 summary: Lessons From the Old Testament of Glycogen Metabolism and the New Testament of Molecular Biology D-chiro-inositol glycans in insulin signaling and insulin resistance Insulin and a Putative Insulin Metabolic Mediator Fraction From Liver and Muscle Stimulate p33 Messenger Ribonucleic Acid Accumulation by Apparently Different Mechanisms Insulin-Mediated Effect on the Activity of UDPG-Glycogen Transglucosylase of Muscle Molecular Basis for the Substrate Specificity of Protein Kinase B; Comparison With MAPKAP Kinase-1 and p70 S6 Kinase Mechanism of Activation of Protein Kinase B by Insulin and IGF-1 Characterization of a 3-Phosphoinositide-Dependent Protein Kinase Which Phosphorylates and Activates Protein Kinase B alpha Inhibition of Glycogen Synthase Kinase-3 by Insulin Mediated by Protein Kinase B Specific Binding of the Akt-1 Protein Kinase to Phosphatidylinositol 3,4,5-Trisphosphate Without Subsequent Activation Mechanism of Activation and Function of Protein Kinase B The Molecular Mechanism by Which Insulin Stimulates Glycogen Synthesis in Mammalian Skeletal Muscle Facts and New Hopes on Selective FGFR Inhibitors in Solid Tumors Membrane Phosphorylation: Activator From Rabbit Skeletal Muscle Molecular Structure of a Protein-Tyrosine/Threonine Kinase Activating p42 Mitogen-Activated Protein (MAP) Kinase: MAP Kinase Kinase Identification and Characterization of a New Mammalian Mitogen-Activated Protein Kinase Kinase, MKK2 A Conserved Kinase Cascade for MAP Kinase Activation in Yeast The MAP Kinase Cascade Is Essential for Diverse Signal Transduction Pathways The Pheromone Response Pathway in Saccharomyces cerevisiae Regulation of the MAP Kinase Cascade Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and In Vitro Raf-1 Activates MAP Kinase-Kinase Raf-1 Is a Potential Substrate for Mitogen-Activated Protein Kinase In Vivo Stimulation of the Stress-Activated Mitogen-Activated Protein Kinase Subfamilies in Perfused Heart. keywords: activation; autophagy; cancer; cells; drug; factor; glycogen; growth; insulin; kinase; neratinib; pathway; phosphorylation; protein; ras; receptor; regulation; signaling; studies; tumor; tyrosine cache: cord-303555-mwu72q7w.txt plain text: cord-303555-mwu72q7w.txt item: #127 of 196 id: cord-303865-vd3qr32o author: Gianturco, Stephanie L. title: Outsourcing facilities and their place in the U.S. drug supply chain date: 2020-08-28 words: 2842 flesch: 43 summary: key: cord-303865-vd3qr32o authors: Gianturco, Stephanie L.; Yoon, SeJeong; Yuen, Melissa V.; Mattingly, Ashlee N. title: Outsourcing facilities and their place in the U.S. drug supply chain date: 2020-08-28 journal: J Am Pharm Assoc (2003) DOI: 10.1016/j.japh.2020.07.021 sha: doc_id: 303865 cord_uid: vd3qr32o OBJECTIVE: The purpose of this commentary is to describe the ideal role of 503B outsourcing facilities in the U.S. drug supply chain. The use of outsourcing facilities to compound ready-to-use drug products is gaining traction in hospitals and other health care systems. keywords: drug; facilities; fda; outsourcing; products cache: cord-303865-vd3qr32o.txt plain text: cord-303865-vd3qr32o.txt item: #128 of 196 id: cord-304506-6el2ryl8 author: Watkins, Laura C. title: Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics date: 2020-09-16 words: 6147 flesch: 32 summary: pH regulation of the influenza virus M2 channel expressed in mouse erythroleukaemia cells Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block The Next Wave of Influenza Drugs Adamantane-resistant influenza a viruses in the world (1902− 2013): frequency and distribution of M2 gene mutations Discovery of M2 channel blockers targeting the drug-resistant double mutants M2-S31N/L26I and M2-S31N/V27A from the influenza A viruses Prospects for Specific Influenza Treatment Viroporins: structure, function and potential as antiviral targets SARS coronavirus E protein forms cation-selective ion channels Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release SARS-CoV-2 and ORF3a: Nonsynonymous Mutations, Functional Domains, and Viral Pathogenesis Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue Histidines, heart of the hydrogen ion channel from influenza A virus: toward an understanding of conductance and proton selectivity Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue Solid-state NMR characterization of conformational plasticity within the transmembrane domain of the influenza A M2 proton channel Structure and mechanism of the M2 proton channel of influenza A virus Mechanisms of proton conduction and gating in influenza M2 proton channels from solid-state NMR Conformational plasticity of the influenza A M2 transmembrane helix in lipid bilayers under varying pH, drug binding, and membrane thickness Effect of cytosolic pH on inward currents reveals structural characteristics of the proton transport cycle in the influenza Exchange Pathways in ClC-ec1 Antiporter Proton-Induced Conformational and Hydration Dynamics in the Influenza A M2 Channel High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel Role of Presolvation and Anharmonicity in Aqueous Phase Hydrated Proton Solvation and Transport A second generation multistate empirical valence bond model for proton transport in aqueous systems Fast Parallel Algorithms for Short-Range Molecular Dynamics Promoting transparency and reproducibility in enhanced molecular simulations PLUMED 2: New feathers for an old bird Multidimensional replicaexchange method for free-energy calculations Python Reference Manual Guide to NumPy Data Structures for Statistical Computing in Python {VMD} -{V}isual {M}olecular {D}ynamics Matplotlib: A 2D graphics environment The chemical and dynamical influence of the anti-viral drug amantadine on the M2 proton channel transmembrane domain Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers Computational study of drug binding to the membrane-bound tetrameric M2 peptide bundle from influenza A virus A secondary gate as a mechanism for inhibition of the M2 proton channel by amantadine Viral M2 ion channel protein: a promising target for anti-influenza drug discovery Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus Identification of camphor derivatives as novel M2 ion channel inhibitors of influenza A virus Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant Expeditious Lead Optimization of Isoxazole-Containing Influenza A Virus M2-S31N Inhibitors Using the Suzuki-Miyaura Cross-Coupling Reaction The conformation of the pore region of the M2 proton channel depends on lipid bilayer environment Atomic structures of closed and open influenza B M2 proton channel reveal the conduction mechanism keywords: binding; channel; drug; excess; hydrogen; influenza; inhibitors; m2 channel; m2 proton; mechanism; proton; proton channel cache: cord-304506-6el2ryl8.txt plain text: cord-304506-6el2ryl8.txt item: #129 of 196 id: cord-304617-5ozf18lg author: Al-Khafaji, Khattab title: Using integrated computational approaches to identify safe and rapid treatment for SARS-CoV-2 date: 2020-05-15 words: 4370 flesch: 42 summary: Here we investigated the role of molecular weight upon the affinity of selected drugs to bind covalently to Cys145, whereas 57% of selected drugs which have molecular weight over than 600 g/ mol ( Figure 2 ). While the ratio of selected drugs decreased to be 16% of drugs which can form covalent bonding with over than À50 kcal/mol. keywords: binding; cov-2; covalent; docking; drugs; mpro; protein; ritonavir; saquinavir; sars cache: cord-304617-5ozf18lg.txt plain text: cord-304617-5ozf18lg.txt item: #130 of 196 id: cord-308994-4nljzm8a author: Tang, Zhongmin title: Insights from nanotechnology in COVID-19 treatment date: 2020-11-04 words: 3243 flesch: 31 summary: As described before, FDA-approved nanomaterials offer unique advantages for antiviral drug delivery, and potential nanomaterial candidates are still emerging. Overall, in addition to the use of clinical equipment to assist patient rehabilitation, antiviral drugs and vaccines are the areas of greatest focus. keywords: antiviral; cov-2; delivery; drugs; nanomaterials; nanotechnology; sars; vaccines; virus cache: cord-308994-4nljzm8a.txt plain text: cord-308994-4nljzm8a.txt item: #131 of 196 id: cord-309025-jo0rqy3y author: Maurya, Priyanka title: Inhalable hybrid nanocarriers for respiratory disorders date: 2020-09-18 words: 6286 flesch: 30 summary: Recent advances in controlled pulmonary drug delivery Pulmonary drug delivery systems for tuberculosis treatment A review on recent technologies for the manufacture of pulmonary drugs Development of an inhalable, stimuli-responsive particulate system for delivery to deep lung tissue Strategies to enhance drug absorption via nasal and pulmonary routes Delivering drugs to the lungs: the history of repurposing in the treatment of respiratory diseases Pulmonary delivery of antitubercular drugs using spray-dried lipid-polymer hybrid nanoparticles A comparison between spray drying and spray freeze drying for dry powder inhaler formulation of drug-loaded lipid-polymer hybrid nanoparticles Nebulised lipid-polymer hybrid nanoparticles for the delivery of a therapeutic anti-inflammatory microRNA to bronchial epithelial cells MicroRNAs as therapeutics for future drug delivery systems in treatment of lung diseases The role of microRNAs in chronic respiratory disease: recent insights Dendritic cells in human lung disease: recent advances Impaired dendritic cell functions in lung cancer: a review of recent advances and future perspectives Coreshell-type lipid-polymer hybrid nanoparticles as a drug delivery platform Development and evaluation of artesunate-loaded chitosan-coated lipid nanocapsule as a potential drug delivery system against breast cancer New surface-modified lipid nanoparticles as delivery vehicles for salmon calcitonin Studies on PEG-modified SLNs loading vinorelbine bitartrate (I): preparation and evaluation in vitro RGD modified and PEGylated lipid nanoparticles loaded with puerarin: formulation, characterization and protective effects on acute myocardial ischemia model Polyelectrolyte stabilized multilayered liposomes for oral delivery of paclitaxel Lipid nanoformulations for oral delivery of bioactives: an overview Dual-ligand modified polymerlipid hybrid nanoparticles for docetaxel targeting delivery to Her2/neu overexpressed human breast cancer cells Evaluation of a polymer-lipid-polymer system utilising hybrid nanoparticles of dapsone as a novel antiacne agent Folate-modified lipidpolymer hybrid nanoparticles for targeted paclitaxel delivery Synthesis and characterization of hybrid polymer/lipid expansile nanoparticles: imparting surface functionality for targeting and stability Quick synthesis of lipid-polymer hybrid nanoparticles with low polydispersity using a single-step sonication method Development and characterization of polymer lipid hybrid nanoparticles for oral delivery of LMWH PEG-detachable lipid-polymer hybrid nanoparticle for delivery of chemotherapy drugs to cancer cells Hybrid poly(lactic-co-glycolic acid) nanoparticles: design and delivery prospectives PLGA/liposome hybrid nanoparticles for short-chain ceramide delivery Preparation and characterization of polymerized liposomes Phosphoinositide-containing polymerized liposomes: stable membrane-mimetic vesicles for protein-lipid binding analysis Chitosan-zein nano-in-microparticles capable of mediating in vivo transgene expression following oral delivery Polymer-lipid hybrid systems: merging the benefits of polymeric and lipid-based nanocarriers to improve oral drug delivery Design of lipid-polymer hybrid nanoparticles for therapy of BPH: part I. Formulation optimization using a design of experiment approach Oxaliplatin immuno hybrid nanoparticles for active targeting: an approach for enhanced apoptotic activity and drug delivery to colorectal tumors One-step synthesis of hybrid nanocrystals with rational tuning of the morphology Development of inhalable hybrid systems has offered manifold advantages to this area of drug delivery. keywords: cancer; cells; chitosan; core; delivery; drug; formulation; hybrid; lipid; lung; mirna; nanoparticles; polymer; shell; systems; targeting cache: cord-309025-jo0rqy3y.txt plain text: cord-309025-jo0rqy3y.txt item: #132 of 196 id: cord-309871-y17puao2 author: Scherrmann, JM. title: Intracellular ABCB1 as a Possible Mechanism to Explain the Synergistic Effect of Hydroxychloroquine-Azithromycin Combination in COVID-19 Therapy date: 2020-06-12 words: 3912 flesch: 22 summary: These aminoquinoline drugs and azithromycin are being repurposed for their clinical use in COVID-19, and they should be evaluated according to current practices of drug clinical trials for this indication. ABCB1, a member of the ATPbinding cassette (ABC) transporter superfamily, is mainly known as being expressed on the cellular plasma membrane in various tissues and can limit the cellular uptake of a large number of drug substrates like azithromycin (37) . keywords: abcb1; azithromycin; chloroquine; covid-19; drug; effect; hydroxychloroquine; lysosomal; virus; vitro cache: cord-309871-y17puao2.txt plain text: cord-309871-y17puao2.txt item: #133 of 196 id: cord-311730-189vax2m author: Becker, Richard C. title: Covid-19 treatment update: follow the scientific evidence date: 2020-04-27 words: 4518 flesch: 34 summary: The number of clinical trials in Covid-19 patients, either planned or ongoing is increasing on a daily basis. [3] ( On March 28, 2020 the United States Food and Drug Administration (FDA issued) an emergency use authorization (EUA) permitting chloroquine phosphate (medical grade) and hydroxychloroquine sulfate to be added to the strategic national stockpile (SNS) (Fig. 2) . keywords: chloroquine; covid-19; disease; drug; effects; health; hydroxychloroquine; patients; potential; qtc; research; sars; treatment cache: cord-311730-189vax2m.txt plain text: cord-311730-189vax2m.txt item: #134 of 196 id: cord-313268-j51zyodw author: Zeng, Xiangxiang title: Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning date: 2020-07-12 words: 4091 flesch: 34 summary: In this study, we present the state-of-the-art knowledge-graph-based, deep-learning methodologies for the rapid discovery of drug candidates to treat COVID-19 from 24 million PubMed publications ( Figure 1 ). 55 To fight the emerging COVID-19 pandemic, we introduced an integrative, network-based, deep-learning methodology to discover candidate drugs for COVID-19, named CoV-KGE. keywords: cov-2; covid-19; data; drugs; human; kge; patients; sars; set; treatment cache: cord-313268-j51zyodw.txt plain text: cord-313268-j51zyodw.txt item: #135 of 196 id: cord-314827-yqr7110e author: Attia, Yasmeen M. title: Successful stories of drug repurposing for cancer therapy in hepatocellular carcinoma date: 2020-09-04 words: 6494 flesch: 23 summary: It also regulates the proliferation of HCC cells via downregulation of p21 and upregulation.of c-Myc autocrine production is essential for malignant transformations in HCC, which once develops, IL-6 paracrine production from KCs start initiating growth and proliferation of HCC cells [65] . keywords: activation; cancer; carcinoma; cells; drug; growth; hcc; hepatocellular; liver; molecular; mtor; pathway; patients; repositioning; stat3; treatment cache: cord-314827-yqr7110e.txt plain text: cord-314827-yqr7110e.txt item: #136 of 196 id: cord-315702-pn8247j2 author: Sahakijpijarn, Sawittree title: Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing date: 2020-09-22 words: 2305 flesch: 29 summary: Figure 5B 417 demonstrates an expansion of 1H-NMR spectra for selected TFF remdesivir powder formulations and 418 remdesivir unprocessed powder. In conclusion, TFF technology produces high potency remdesivir dry powder formulations for inhalation suitable to treat patients with COVID-19 on an outpatient basis and earlier in the disease course where effective antiviral therapy can reduce related morbidity and mortality. keywords: drug; formulations; freezing; inhalation; powder; remdesivir; tff; water cache: cord-315702-pn8247j2.txt plain text: cord-315702-pn8247j2.txt item: #137 of 196 id: cord-315918-12rbbe8c author: Mukherjee, Pulok K. title: Antiviral Evaluation of Herbal Drugs date: 2019-06-21 words: 12824 flesch: 39 summary: Many combinations of test viruses are possible, but a battery of six viruses seems to be quite acceptable. This assay is applicable for HIV-1, simian immunodeficiency virus (SIV), and simian-HIV and is carried out in TZM-bl cells as it reveal the reduction in Tat-induced luciferase (Luc) reporter gene expression after a single round of virus infection. keywords: acid; activities; activity; antiviral; assay; cells; compounds; control; culture; drug; et al; extracts; herpes; hiv; incubate; infection; medicinal; medium; plant; replication; screening; test; virus; viruses cache: cord-315918-12rbbe8c.txt plain text: cord-315918-12rbbe8c.txt item: #138 of 196 id: cord-316029-z708c3ex author: Brunsdon, Priya title: Clinical Pharmacology Considerations for Developing Small‐Molecule Treatments for COVID‐19 date: 2020-07-12 words: 4969 flesch: 32 summary: A systematic review Gentamicin volume of distribution in critically ill septic patients Antimicrobial pharmacokinetic and pharmacodynamic issues in the critically ill with severe sepsis and septic shock Effect of alpha-1-acid glycoprotein binding on pharmacokinetics and pharmacodynamics Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Impact of infectious and inflammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics The Impact of Renal Impairment on Patient Drug Response -Assessing the Need for a Consensus Approach Acute kidney injury in patients hospitalized with COVID-19 Kidney involvement in COVID-19 and rationale for extracorporeal therapies COVID-19 and kidney failure in the acute care setting: our experience from Seattle Pharmacokinetic principles during continuous renal replacement therapy: drugs and dosage Assessment of the impact of renal impairment on systemic exposure of new molecular entities: evaluation of recent new drug applications Hydroxychloroquine as an aerosol might markedly reduce and even prevent severe clinical symptoms after SARS-CoV-2 infection Virological assessment of hospitalized patients with COVID-2019 Working to supply remdesivir for COVID-19 Inhalation drug delivery devices: technology update A review of nebulized drug delivery in COPD Determination of the relative bioavailability of salbutamol to the lungs and systemic circulation following nebulization Practical strategies for a safe and effective delivery of aerosolized medications to patients with COVID-19 A guide to drug therapy in patients with enteral feeding tubes: dosage form selection and administration methods Therapeutic concerns when oral medications are administered nasogastrically Clogged feeding tubes: a clinician's thorn Medication administration through enteral feeding tubes Estimates of the severity of coronavirus disease 2019: a model-based analysis A call for the appropriate application of clinical pharmacological principles in the search for safe and efficacious COVID-19 (SARS-COV-2) treatments Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease Rates of Cases, Hospitalizations and Deaths by Race/Ethnicity Group COVID-19: They are based on the major observed disease complications that impact drug absorption, distribution, metabolism, and elimination. keywords: absorption; acute; administration; covid-19; disease; dosing; drug; hemodialysis; patients; therapies; treatment cache: cord-316029-z708c3ex.txt plain text: cord-316029-z708c3ex.txt item: #139 of 196 id: cord-316792-89f8g0m8 author: Herzig, Volker title: Animal toxins — Nature’s evolutionary-refined toolkit for basic research and drug discovery date: 2020-06-12 words: 12772 flesch: 35 summary: One therapeutic area in which venom peptides have been successfully used to identify new drug targets is chronic pain In addition to venom peptides, non-peptidic marine toxins have proven to be invaluable tools for elucidating diverse pain pathways. keywords: acid; activity; animal; asic1a; channel; cold; complement; development; disease; drug; effects; factor; human; ion; neurons; novel; pain; peptides; potential; role; selective; selectivity; sensing; snake; spider; structure; target; toxins; use; venom cache: cord-316792-89f8g0m8.txt plain text: cord-316792-89f8g0m8.txt item: #140 of 196 id: cord-317435-4yuw7jo3 author: Zhou, Yadi title: Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2 date: 2020-03-16 words: 7795 flesch: 30 summary: Mesalamine induced eosinophilic pneumonia Translational high-dimensional drug interaction discovery and validation using health record databases and pharmacokinetics models MEGA X: molecular evolutionary genetics analysis across computing platforms Enrichr: a comprehensive gene set enrichment analysis web server 2016 update DrugBank 4.0: shedding new light on drug metabolism Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information ChEMBL: a large-scale bioactivity database for drug discovery BindingDB: a webaccessible database of experimentally determined protein-ligand binding affinities The IUPHAR/BPS Guide to PHARMACOLOGY: an expertdriven knowledgebase of drug targets and their ligands UniProt: the Universal Protein knowledgebase Database resources of the National Center for Biotechnology Information Conformational dynamics and allosteric regulation landscapes of germline PTEN mutations associated with autism compared to those associated with cancer Expression profile of immune response genes in patients with severe acute respiratory syndrome Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus SREBP-dependent lipidomic reprogramming as a broadspectrum antiviral target Discovery and preclinical validation of drug indications using compendia of public gene expression data This work was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) under Award Number K99 HL138272 and R00 HL138272 to F.C. In this study, we present an integrative, antiviral drug repurposing methodology implementing a systems pharmacology-based network medicine platform, quantifying the interplay between the HCoV–host interactome and drug targets in the human protein–protein interaction network. keywords: combinations; coronavirus; cov-2; drug; fig; gene; hcov; host; human; interactome; ncov; network; potential; proteins; sars; targets; virus cache: cord-317435-4yuw7jo3.txt plain text: cord-317435-4yuw7jo3.txt item: #141 of 196 id: cord-317971-kuwargnp author: Opatz, Till title: Thoughts on What Chemists Can Contribute to Fighting SARS‐CoV‐2 – A Short Note on Hand Sanitizers, Drug Candidates and Outreach date: 2020-05-08 words: 2889 flesch: 47 summary: On March 4, the Bundesanstalt fürA rbeitsschutz und Arbeitsmedizin (BAuA), [16] the relevant regulatory body in Germany,issued adecree that allowed pharmacies to produce hand sanitizer solutions locally. Synthesizing chiral phosphoramidates of this level of complexity is as ynthetic challenge, [37] and so is the synthesis of other drug candidates for treating the virus that will be identified by homology modeling and targetbased virtual ligand screening or conventional medicinal chemistry approaches. keywords: chemists; drug; ethanol; formulation; hand; isopropanol; production; sars; solutions; virus cache: cord-317971-kuwargnp.txt plain text: cord-317971-kuwargnp.txt item: #142 of 196 id: cord-317993-012hx4kc author: Movia, Dania title: Preclinical Development of Orally Inhaled Drugs (OIDs)—Are Animal Models Predictive or Shall We Move Towards In Vitro Non-Animal Models? date: 2020-07-24 words: 6888 flesch: 35 summary: The so-called lung-on-chip is a microfluidic-based in vitro system in which lung epithelial cells are grown on one side of a membrane, and stromal cells on the other surface. Semin Heuze-Vourc'h, N. Innovative preclinical models for pulmonary drug delivery research Options for modeling the respiratory system: Inserts, scaffolds and microfluidic chips A biphasic chamber system for maintaining polarity of differentiation of cultured respiratory tract epithelial cells Adapting the Electrospinning Process to Provide Three Unique Environments for a Tri-layered In Vitro Model of the Airway Wall Use of porous membranes in tissue barrier and co-culture models A novel electrospun biphasic scaffold provides optimal three-dimensional topography for in vitro co-culture of airway epithelial and fibroblast cells Intermittent exposure to whole cigarette smoke alters the differentiation of primary small airway epithelial cells in the air-liquid interface culture ALI multilayered co-cultures mimic biochemical mechanisms of the cancer cell-fibroblast cross-talk involved in NSCLC MultiDrug Resistance Multilayered Cultures of NSCLC cells grown at the Air-Liquid Interface allow the efficacy testing of inhaled anti-cancer drugs Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke Altered generation of ciliated cells in chronic obstructive pulmonary disease Primary epithelial cell models for cystic fibrosis research Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus Regeneration of the lung: Lung stem cells and the development of lung mimicking devices In vitro generation of human pluripotent stem cell derived lung organoids A three-dimensional model of human lung development and disease from pluripotent stem cells Modelling Cryptosporidium infection in human small intestinal and lung organoids Use of three-dimensional organoids and lung-on-a-chip methods to study lung development, regeneration and disease Organoids as a Powerful Model for Respiratory Diseases Lung-On-A-Chip Technologies for Disease Modeling and Drug Development Reconstituting organ-level lung functions on a chip A human breathing lung-on-a-chip A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice A lung/liver-on-a-chip platform for acute and chronic toxicity studies A 3D human lung-on-a-chip model for nanotoxicity testing Multiorgan microfluidic platform with breathable lung chamber for inhalation or intravenous drug screening and development Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: A biopharmaceutical perspective Impaired Wound Healing of Alveolar Lung Epithelial Cells in a Breathing Lung-On-A-Chip Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID19 therapeutics in viral pandemics Biomimetic human lung-on-a-chip for modeling disease investigation Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung Modeling the lung: keywords: animal; cell; chip; delivery; development; disease; drug; human; inhalation; lung; models; oid; oids; studies; vitro cache: cord-317993-012hx4kc.txt plain text: cord-317993-012hx4kc.txt item: #143 of 196 id: cord-318048-6nvi63rq author: Arshad, Usman title: Prioritisation of Anti‐SARS‐Cov‐2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics date: 2020-05-21 words: 5673 flesch: 40 summary: Antiviral drugs are urgently required for treatment of patients with mild/moderate disease to prevent the worsening of symptoms and reduce the burden upon healthcare systems. In the absence of a vaccine, antiviral drugs could also be deployed as chemoprophylaxis to protect against infection and would present an essential tool for protecting healthcare staff and other key workers, as well as household contacts of those already infected. keywords: activity; analysis; cmax; concentrations; cov-2; data; drugs; lung; plasma; sars; tissue cache: cord-318048-6nvi63rq.txt plain text: cord-318048-6nvi63rq.txt item: #144 of 196 id: cord-320172-qw47pf9r author: Greaves, Peter title: VII Digestive System 1 date: 2000-12-31 words: 47447 flesch: 33 summary: It has been suggested from studies of the effects of anticancer compounds on neoplastic colonic cells that intestinal cells may possess inherent protective properties in the form of an accelerated efflux pump which can serve to protect them from potentially damaging agents (Klohs and Steinkampf, 1986) . A histochemical study Role of intestinal metaplasia in the histogenesis of gastric carcinoma Colorectal mucin histochemistry in health and disease: A critical review Uptake of particulate and soluble antigens in the small intestines of the rat Chemical colitis due to endoscopic cleaning solutions: A mimic of pseudomembranous colitis Pathology of Domestic Animals Intestinal accumulation of urea in germ-free animals: A factor in caecal enlargement Digestive enzymes in the parotid and submandibular glands of mammals Morphologishe Veränderungen der Magenmukosa von Ratten nach chronischer Antazidagabe Enteric viruses of non human primates Increased accumulation of sulfated glycoaminoglycans in cultures of human fibroblasts from phenytoin-induced gingival overgrowth New insights into the stem cells and the precursors of gastric epithelium Colonic lymphoid-glandular complex (microbursa): Nature and morphology Lymphoid tissue and lymphoid-glandular complexes of the colon: Relation to diverticulosis Histology of salivary gland infarction in the dog Adrenergic factors involved in the control of crypt cell proliferation in jejunum and descending colon of mouse Pill esophagitis Immunogold localization of ingested kidney bean (Phaseolus vugaris) lectins in epithelial cells of the rat small intestine Epithelial dysplasia of the rabbit colon induced by degraded carrageenan Hyperkeratinization and hyperplasia of the forestomach epithelium in vitamin A deficient rats Intrinsic resistance of colon tumors to anthrapyrazoles and antracyclines may be linked with a detoxification mechanism of intestinal cells (Abstract No. 1040) keywords: acid; activity; administration; agents; animals; cells; changes; chronic; colon; colonic; crypt; damage; differences; disease; dogs; drugs; effects; epithelium; et al; factor; features; forestomach; form; gastric; gastric mucosa; gastrointestinal; glands; glandular; goblet cells; growth; high; human; hyperplasia; increase; inflammation; inflammatory; intestine; laboratory; lesions; lymphocytes; lymphoid; man; metaplasia; mice; mouse; mucins; mucosa; non; number; oral; presence; rats; result; rodents; salivary; secretion; species; stomach; studies; study; surface; tissue; tract; treatment; ulceration; ulcers cache: cord-320172-qw47pf9r.txt plain text: cord-320172-qw47pf9r.txt item: #145 of 196 id: cord-321230-b5a1z14w author: Samji, Hasina title: Drug-related deaths in a population-level cohort of people living with and without hepatitis C virus in British Columbia, Canada date: 2020-10-19 words: 5476 flesch: 38 summary: The Lancet Psychiatry Modelling the combined impact of interventions in averting deaths during a synthetic-opioid overdose epidemic Prevalence of injecting drug use and coverage of interventions to prevent HIV and hepatitis C virus infection among people who inject drugs in Canada Changing dynamics of the drug overdose epidemic in the United States from 1979 through Identifying injection drug use and estimating population size of people who inject drugs using healthcare administrative datasets Assessing hepatitis C burden and treatment effectiveness through the British Columbia hepatitis testers cohort (BC-HTC): Design and characteristics of linked and unlinked participants Twin epidemics of new and prevalent hepatitis C infections in Canada: BC Hepatitis Testers Cohort The impact of HCV SVR from direct acting antiviral and interferon-based treatments on mortality in a large population based cohort study Changes in synthetic opioid involvement in drug overdose deaths in the United States Known fentanyl use among clients of harm reduction sites in British Columbia What is killing people with hepatitis C virus infection? The median age of DRD in our study among HCV-negative individuals was 37 years (vs. 49 years among PLHCV); similarly, provincial data on overdose deaths illustrates that people between the ages of 30 and 39 years had the highest rate of illicit drug overdose deaths (57.4 per 100,000 person years) in 2018 (BC Coroners Service, 2020a). keywords: data; deaths; drds; drug; hcv; health; individuals; mortality; plhcv; use cache: cord-321230-b5a1z14w.txt plain text: cord-321230-b5a1z14w.txt item: #146 of 196 id: cord-321267-ihd30qi0 author: Daughton, Christian G. title: Natural experiment concept to accelerate the Re-purposing of existing therapeutics for Covid-19 date: 2020-05-15 words: 5354 flesch: 37 summary: Many different scenarios can be hypothesized for how drug usage might be associated with Covid-19 clinical outcomes. This would entail a more ambitious data collection effort involving collaboration with industrial and environmental toxicologists to extend the utility beyond drug usage by broadening the exposome and incorporating known occupational and environmental hazards. keywords: covid-19; disease; drugs; infection; negative; nerd; potential; test; testing; usage cache: cord-321267-ihd30qi0.txt plain text: cord-321267-ihd30qi0.txt item: #147 of 196 id: cord-321379-7bpl5n3j author: Singh, Sweta title: Coronavirus disease 2019 drug discovery through molecular docking date: 2020-06-03 words: 3996 flesch: 53 summary: Remdesivir was detected as COVID-19 inhibitory drug via virtual screening method 6 . The rest of the molecules could also be used as COVID-19 inhibitory drugs after further evaluation. keywords: 6m03; authors; binding; covid-19; docking; drugs; energy; molecules; protease; results cache: cord-321379-7bpl5n3j.txt plain text: cord-321379-7bpl5n3j.txt item: #148 of 196 id: cord-321657-2s1npse5 author: Du, Sean Quan title: Mathematical modeling of interaction between innate and adaptive immune responses in COVID‐19 and implications for viral pathogenesis date: 2020-05-13 words: 6465 flesch: 55 summary: A first step in understanding SARS pathogenesis Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCoV Principles and Practice of Clinical Virology Defense mechanisms against influenza virus infection in the respiratory tract mucosa Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia Mathematical analysis of viral replication dynamics and antiviral treatment strategies: from basic models to age-based multi-scale modeling Population dynamics of immune responses to persistent viruses Viral dynamics in hepatitis B virus infection Virus dynamics and drug therapy Mathematical models of HIV pathogenesis and treatment Virus Dynamics: Mathematical Principles of Immunology and Virology Influenza and the challenge for immunology Cell-mediated protection in influenza infection Pathogenesis of emerging Avian influenza viruses in mammals and the host innate immune response Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza a virus Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy Effects of antirejection drugs on innate immune cells after Kidney transplantation Immunobiology: Antiviral drugs and immunosuppressive drugs have been evaluated as potential treatments for high-risk patients. keywords: air; cells; drug; effect; patients; peak; target; target cells; virus cache: cord-321657-2s1npse5.txt plain text: cord-321657-2s1npse5.txt item: #149 of 196 id: cord-321741-aq76s37x author: Andersen, Petter I. title: Discovery and development of safe-in-man broad-spectrum antiviral agents date: 2020-04-30 words: 5447 flesch: 26 summary: RFP-expressing RVFV, nanoLuc-expressing CHIKV and RRV, as well as GFP-expressing FLUAV, HCV and HMPV also allowed identification of novel activities of several BSAAs (Andersen et al., 2019b; Bosl et al., 2019; de Graaf et al., 2007; Habjan et al., 2008; Ianevski et al., 2018; Jupille et al., 2011; Kittel et al., 2004; Lee et al., 2017; Utt et al., 2016) . Therefore, repositioning of launched or even failed drugs to viral diseases provides unique translational opportunities, including a substantially higher probability of success to market as compared with developing new virus-specific drugs and vaccines, and a significantly reduced cost and timeline to clinical availability Pizzorno et al., 2019; Zheng et al., 2018) . keywords: activities; agents; antiviral; assays; bsaas; cells; development; drug; et al; human; infections; novel; replication; studies; treatment; virus; viruses; zika cache: cord-321741-aq76s37x.txt plain text: cord-321741-aq76s37x.txt item: #150 of 196 id: cord-322885-ob5euspo author: Durdagi, Serdar title: Near-Physiological-Temperature Serial Femtosecond X-ray Crystallography Reveals Novel Conformations of SARS-CoV-2 Main Protease Active Site for Improved Drug Repurposing date: 2020-09-09 words: 10828 flesch: 43 summary: These two highresolution SFX structures in different space groups reveal new active site residue conformations and intra-and inter-domain network and their dynamics at the atomic level, which helps us to better understand any related structural allosteric transitions of Mpro structure interacting with the inhibitors (Fig. 5 & figs. Additionally, Mpro structure bound to a non-covalent inhibitor (PDB ID: 6W63) in both monomeric and dimeric forms was utilized as target structure. keywords: 7cwc; binding; chain; coronavirus; cov-2; crystal; domain; drug; et al; fig; inhibitors; mpro; protease; protein; repurposing; residues; sars; sfx; simulations; site; space; structures; studies; temperature cache: cord-322885-ob5euspo.txt plain text: cord-322885-ob5euspo.txt item: #151 of 196 id: cord-322915-zrjx31ev author: Demain, Arnold L title: Microbial drug discovery: 80 years of progress date: 2009-01-09 words: 11264 flesch: 36 summary: Furthermore, reports have been published on natural product inhibitors of HIV integrase obtained from among the marine ascidian alkaloids; that is, the lamellarins (produced by the mollusk Lamellaria sp.), and from terrestrial plants (Baccharis genistelloides and Achyrocline satureioides). The FAM (5-fluorouracil, adriamycin, mitomycin C) and SMF (streptozotocin, mitomycin C, 5-fluorouracil) chemotherapy regimens Mitomycin dimers: polyfunctional cross-linkers of DNA Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin GLUT2 in pancreatic islets: crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice Improved production of pentostatin and identification of fermentation cometabolites Pentostatin in T-non-Hodgkin's lymphomas: efficacy and effect on CD26+ T lymphocytes Cleavage behavior of calicheamicin gamma 1 and calicheamicin T Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia Study on the preparation and regeneration of protoplast from taxol-producing fungus Nodulisporium sylviforme Natural products as sources of new drugs over the last 25 years Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria): production, physico-chemical and biological properties Epothilones, a new class of microtubulestabilizing agents with a taxol-like mechanism of action Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol) keywords: acid; activity; agents; antibiotics; bacteria; cancer; cell; compounds; development; discovery; disease; drugs; gram; growth; health; hiv; human; infections; inhibitors; microbial; patients; production; products; resistance; streptomyces; treatment; use; years cache: cord-322915-zrjx31ev.txt plain text: cord-322915-zrjx31ev.txt item: #152 of 196 id: cord-323940-ubazgvov author: Cafiero, Concetta title: Pharmacogenomics and Pharmacogenetics: In Silico Prediction of Drug Effects in Treatments for Novel Coronavirus SARS-CoV2 Disease date: 2020-10-13 words: 7372 flesch: 26 summary: • PharmGKB website provides a diverse array of PGx information, from annotations of the primary literature to guidelines for adjusting drug treatment based on genetic information. To our knowledge, although a considerable number of ADR episodes in Covid-19 patients have to date been described in the literature, there has been no pharmacogenetic study attempting to correlate the clinical outcomes of drug treatment with gene variants. keywords: coronavirus; cov2; covid-19; disease; drug; effects; efficacy; infection; patients; pharmacogenetic; response; sars; studies; study; therapy; toxicity; treatment; use; variants cache: cord-323940-ubazgvov.txt plain text: cord-323940-ubazgvov.txt item: #153 of 196 id: cord-324166-6ydn2bvy author: Kumar, Neeraj title: Antitussive noscapine and antiviral drug conjugates as arsenal against COVID-19: a comprehensive chemoinformatics analysis date: 2020-08-20 words: 5489 flesch: 37 summary: key: cord-324166-6ydn2bvy authors: Kumar, Neeraj; Awasthi, Amardeep; Kumari, Anchala; Sood, Damini; Jain, Pallavi; Singh, Taru; Sharma, Neera; Grover, Abhinav; Chandra, Ramesh title: Antitussive noscapine and antiviral drug conjugates as arsenal against COVID-19: a comprehensive chemoinformatics analysis date: 2020-08-20 journal: Journal of biomolecular structure & dynamics DOI: 10.1080/07391102.2020.1808072 sha: doc_id: 324166 cord_uid: 6ydn2bvy Coronavirus pandemic has caused a vast number of deaths worldwide. The receptor grid was set to 0.6 Å for X, Y, and Z coordinates of Mpro structure. keywords: analysis; binding; conjugate; coronavirus; drug; energy; hcq; mpro; nos; noscapine; protein; sars cache: cord-324166-6ydn2bvy.txt plain text: cord-324166-6ydn2bvy.txt item: #154 of 196 id: cord-324660-w81jgw7p author: Guharoy, Roy title: Medication Shortages: A Matter of National Security—Time for Action date: 2020-08-01 words: 1106 flesch: 38 summary: As supply chain management leaders at Mayo Clinic, we appreciate the attention these authors draw towards the issue of drug shortages and drug costs. One of the interesting observations we have made from the supply chain perspective while navigating the coronavirus disease 2019 (COVID-19) pandemic is that the impacts on drug cost from COVID-19 have been minimal in the retail segment and are more significant in the hospital sector. keywords: covid-19; drug; shortages; supply cache: cord-324660-w81jgw7p.txt plain text: cord-324660-w81jgw7p.txt item: #155 of 196 id: cord-325019-hznnoxw6 author: Benavides-Cordoba, Vicente title: Drug Repositioning for COVID-19 date: 2020-06-30 words: 2902 flesch: 33 summary: COVID-19) -events as they happen Therapeutic options for the 2019 novel coronavirus (2019-nCoV) Immune responses in COVID-19 and potential vaccines: lessons learned from SARS and MERS epidemic Challenges in early clinical development of adjuvanted vaccines Organs-on-chips at the frontiers of drug discovery Why drugs fail in clinical trials in pulmonary arterial hypertension, and strategies to succeed in the future An analysis of the attrition of drug candidates from four major pharmaceutical companies Drug repurposing: progress, challenges and recommendations Drug Repositioning: Identifying and developing new uses for existing drugs From off-label to repurposed drug in nononcological rare diseases: definition and state of the art in selected EU countries Overcoming the legal and regulatory barriers to drug repurposing Can you teach old drugs new tricks? In this review, we present a selection of drugs, of different classes and with potential activity against COVID-19, whose trials are ongoing; and as proofs of concept, double blind, add-on event-driven, would allow proposing research that generates results in less time and preserving quality criteria for drug development and approval by regulatory agencies. keywords: covid-19; drug; hydroxychloroquine; patients; repositioning; repurposing; treatment; trials cache: cord-325019-hznnoxw6.txt plain text: cord-325019-hznnoxw6.txt item: #156 of 196 id: cord-325315-m3do6t1j author: Rossi, Carlo Maria title: A case report of toxic epidermal necrolysis (TEN) in a patient with COVID-19 treated with hydroxychloroquine: are these two partners in crime? date: 2020-10-06 words: 2544 flesch: 38 summary: More risk factors result in a higher score and a higher mortality rate (%) as follows: Toxic epidermal necrolysis and Stevens-Johnson syndrome Cytotoxic proteins and therapeutic targets in severe cutaneous adverse reactions The epidemeology and pathogensis of coronavirus (Covid-19) outbreak Clinical features of patients infected with 2019 novel coronavirus in Wuhan COVID-19: combining antiviral and anti-inflammatory treatments SARS CoV-2: recent Reports on antiviral therapies based on lopinavir/ritonavir, darunavir/umifenovir, hydroxychloroquine, remdesivir, favipiravir and other drugs for the treatment of the new coronavirus In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) A trial of lopinavir-ritonavir in adults hospitalized with severe covid-19 Tocilizumab in severe COVID-19 pneumonia and concomitant cytokine release syndrome an algorithm for assessment of drug causality in stevens-johnson syndrome and toxic epidermal necrolysis: comparison with case-control analysis Toxic epidermal necrolysis with prominent facial pustules: a case with reactivation of human herpesvirus 7 Toxic epidermal necrolysis and Stevens-Johnson syndrome are induced by soluble fas ligand Immune pathomechanism and classification of drug hypersensitivity Classification of drug hypersensitivity into allergic, p-i, and pseudo-allergic forms. EudraVigilance Oped Data ADR hydroxychloroquine Drug reaction with eosinophilia and systemic symptoms syndrome to hydroxychloroquine, an old drug in the spotlight Generalized pustular figurate erythema: a newly delineated severe cutaneous drug reaction linked with hydroxychloroquine Cutaneous side-effects of the potential COVID-19 drugs Drug hypersensitivity in HIV infection The interferon-γinduced protein 10/CXCR3 axis is associated with human herpesvirus-6 reactivation and the development of sequelae in drug reaction with eosinophilia and systemic symptoms Reactivation of cytomegalovirus in a patient with Stevens-Johnson syndrometoxic epidermal necrolysis Toxic epidermal necrolysis: Part II. keywords: covid-19; drug; epidermal; hydroxychloroquine; necrolysis; patient; skin; syndrome cache: cord-325315-m3do6t1j.txt plain text: cord-325315-m3do6t1j.txt item: #157 of 196 id: cord-325473-hrdanbn1 author: Ghahremanpour, Mohammad M. title: Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2 date: 2020-08-28 words: 2920 flesch: 49 summary: Remarkably, fourteen of the drugs at 100 μM decreased M pro activity (100 nM), as shown in Figure 5 and Table 2 . Five drugs decreased M pro activity to below 40%. keywords: compounds; cov-2; covid-19; docking; drug; inhibitors; protease; sars cache: cord-325473-hrdanbn1.txt plain text: cord-325473-hrdanbn1.txt item: #158 of 196 id: cord-326922-bajpr5a2 author: Watson, C. James title: Pharmaceutical Compounding: a History, Regulatory Overview, and Systematic Review of Compounding Errors date: 2020-11-02 words: 7103 flesch: 32 summary: Supplemental Outsourced compounding can be problematic Meningitis outbreak reveals gaps in US drug regulation Regulating compounding pharmacies after NECC How gaps in regulation of compounding pharmacy set the stage for a multistate fungal meningitis outbreak Fungal infections associated with contaminated methylprednisolone in Tennessee Fungal infections associated with contaminated methylprednisolone injections Human drug compounding. Despite Congress's attempt to strengthen oversight of compounding pharmacies, litigation challenging FDAMA tempered the FDA's authority to regulate compounders. keywords: administration; compounding; contamination; drug; errors; facilities; fda; food; medications; outbreak; outsourcing; patients; pharmacies; pharmacy; states; united cache: cord-326922-bajpr5a2.txt plain text: cord-326922-bajpr5a2.txt item: #159 of 196 id: cord-328559-2qvxw896 author: LeSaint, Kathy T. title: Impact of Social Distancing on Individuals Who Use Drugs: Considerations for Emergency Department Providers date: 2020-08-18 words: 1612 flesch: 39 summary: [9] [10] [11] In addition, opioid treatment programs are providing longer durations of take-home doses of medications for treatment of opioid use disorder. A systematic review of quantitative and qualitative studies Management of opioid use disorder in the emergency department: a white paper prepared for the American Academy of Emergency Medicine Initiating buprenorphine treatment in the emergency department Emergency department clinicians' attitudes toward opioid use disorder and emergency department-initiated buprenorphine treatment: a mixed-methods study Considerations for crisis centers and clinicians in managing the treatment of alcohol or benzodiazepine withdrawal during the COVID-19 epidemic keywords: distancing; emergency; people; treatment; use cache: cord-328559-2qvxw896.txt plain text: cord-328559-2qvxw896.txt item: #160 of 196 id: cord-328705-024y5k72 author: Rahman, Md. Mahbubur title: Virtual screening, molecular dynamics and structure–activity relationship studies to identify potent approved drugs for Covid-19 treatment date: 2020-07-21 words: 4491 flesch: 45 summary: Several promising approved drugs, including Simeprevir, Ergotamine, Bromocriptine and Tadalafil, stand out as the best candidates based on their binding energy, fitting score and noncovalent interactions at the binding sites of the receptor. Drug repurposing, a strategy to identify new uses of approved drugs, could shorten the time and reduce the cost for identifying effective drugs against COVID-19 . keywords: binding; complexes; drugs; energy; mpro; protease; protein; sars; simulation cache: cord-328705-024y5k72.txt plain text: cord-328705-024y5k72.txt item: #161 of 196 id: cord-329318-eo8auo1f author: Gusarov, Sergey title: COSMO-RS-Based Descriptors for the Machine Learning-Enabled Screening of Nucleotide Analogue Drugs against SARS-CoV-2 date: 2020-10-26 words: 3973 flesch: 38 summary: In this study, we propose a novel set of drug screening descriptors based on COSMO-RS σ-profiles, augmented by dipole moment and induced charge of the phosphorus atom, to evaluate the chemical similarity of the drugs with nucleotides, as RNA replication transcription initiation activators. 13, 14 Computational data-driven approaches for drug screening are particularly useful for the identification of drug candidates. keywords: chemical; cosmo; cov-2; descriptors; docking; drug; sars; screening; set cache: cord-329318-eo8auo1f.txt plain text: cord-329318-eo8auo1f.txt item: #162 of 196 id: cord-329881-9vnz5zzg author: Garcia, Sònia title: Pandemics and Traditional Plant-Based Remedies. A Historical-Botanical Review in the Era of COVID19 date: 2020-08-28 words: 6222 flesch: 38 summary: Besides, in the USA a group of doctors known as The Eclectics got positive results by treating the flu symptoms with plant remedies, together with other measures that included exercise. Front Plant Sci DOI: 10.3389/fpls.2020.571042 sha: doc_id: 329881 cord_uid: 9vnz5zzg Pandemics are as old as humanity and since ancient times we have turned to plants to find solutions to health-related problems. keywords: century; covid19; disease; drugs; et al; malaria; medicine; pandemic; people; plague; plant; treatment; tuberculosis; virus cache: cord-329881-9vnz5zzg.txt plain text: cord-329881-9vnz5zzg.txt item: #163 of 196 id: cord-330380-wnbyy1gk author: Liu, Tingting title: Applying high-performance computing in drug discovery and molecular simulation date: 2016-01-11 words: 8601 flesch: 33 summary: Drug targets are commonly associated with a desirable therapeutic effect or an unwanted adverse effect [20] . experimental and computational studies Virtual screening for finding natural inhibitor against cathepsin-L for SARS therapy Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5 Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2 Drug repositioning for personalized medicine TarFisDock: a web server for identifying drug targets with docking approach PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach Silico target fishing: addressing a Big Data problem by ligand-based similarity rankings with data fusion On the properties of bit string-based measures of chemical similarity Extended-connectivity fingerprints Relating protein pharmacology by ligand chemistry Drug therapy: drug-induced prolongation of the QT interval TarPred: a web application for predicting therapeutic and side effect targets of chemical compounds DRAR-CPI: a server for identifying drug repositioning potential and adverse drug reactions via the chemical-protein interactome iDrug: a web-accessible and interactive drug discovery and design platform A 3D model of SARS CoV 3CL proteinase and its inhibitors design by virtual screening Putative hAPN receptor binding sites in SARS CoV spike protein Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A In vitro biochemical and thermodynamic characterization of nucleocapsid protein of SARS Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization. keywords: binding; compounds; data; design; development; discovery; docking; drug; drug discovery; hpc; inhibitors; medicine; protein; screening; simulation; structure; studies; target cache: cord-330380-wnbyy1gk.txt plain text: cord-330380-wnbyy1gk.txt item: #164 of 196 id: cord-331633-ix5un6c9 author: Teixeira, Maria C. title: Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs) date: 2020-03-20 words: 9145 flesch: 27 summary: Furthermore, nanomaterials can be used for antimicrobial drug delivery, and the incorporation of antimicrobial nanomaterials in medical devices and implants can prevent microbial adhesion and infection Antimicrobial drug delivery using polymeric NPs offers several advantages: (i) structural stability in biological fluids and under harsh and various conditions for preparation; (ii) precisely tuneable properties, such as size, zeta-potentials, and drug release profiles, by manipulating polymer lengths, surfactants, and organic solvents used for NP preparation [67] , and (iii) facile and versatile surface functionalization for conjugating drugs and targeting ligands [68] . keywords: activity; amps; antibiotics; bacteria; delivery; development; drug; effects; lipid; nanomaterials; nanoparticles; nps; peptide; properties; resistance; systems; use cache: cord-331633-ix5un6c9.txt plain text: cord-331633-ix5un6c9.txt item: #165 of 196 id: cord-332038-icyut3xa author: Pillaiyar, Thanigaimalai title: A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery date: 2020-04-02 words: 11290 flesch: 33 summary: Schein Update on the management of rosacea: a status report on the current role and new horizons with topical azelaic acid Cure of condylomaacuminata covering the glans penis using aminolevulinic acid/photodynamic therapy A phase 1 study of azacitidine with high-dose cytarabine and mitoxantrone in high-risk acute myeloid leukemia Quinine an old anti-malarial drug in a modern world: role in the treatment of malaria Antiviral effects of quinine sulfate on HSV-1 HaCat cells infected: analysis of the molecular mechanisms involved Inhibition of influenza virus replication by targeting broad host cell pathways Quinoline hybrids and their antiplasmodial and antimalarial activities Evaluation of antiplasmodial potential of C2 and C8 modified quinolines: in vitro and in silico Astemizole analogues with reduced hERG inhibition as potent antimalarial compounds Liver-stage malaria parasites vulnerable to diverse chemical scaffolds New leads for drug repurposing against malaria Repurposing drugs to target the malaria parasite unfolding protein response Repositioning Salirasib as a new antimalarial agent Triazole derivatives and their antiplasmodial and antimalarial activities Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues World Alzheimer Report 2010: the global economic impact of dementia (Alzheimer's disease international The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models Alzheimer's disease Aligning the evidence with practice: NICE guidelines for drug treatment of Alzheimer's disease The exploration of novel Alzheimer's therapeutic agents from the pool of FDA approved medicines using drug repositioning, enzyme inhibition and kinetic mechanism approaches The prokinetic cinitapride has no clinically relevant pharmacokinetic interaction and effect on qt during coadministration with ketoconazole Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds Treating Alzheimer's disease by targeting iron Tarenflurbil Phase 3 Study Group. Salirasib (72, Figure 6 ) is a promising cancer drug candidate inhibits isoprenylcysteine carboxyl methyltransferase (ICMT), a validated target for cancer drug development. keywords: acid; activity; alzheimer; amyloid; brain; cancer; cells; development; disease; drug; effects; figure; inhibition; inhibitors; leukemia; parkinson; patients; potential; repurposing; risk; studies; study; treatment; tyrosinase cache: cord-332038-icyut3xa.txt plain text: cord-332038-icyut3xa.txt item: #166 of 196 id: cord-332271-slouuryl author: Baker, Jeremy D. title: A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV-2 main protease date: 2020-08-27 words: 2694 flesch: 41 summary: Infection usually resolves without active medical intervention, but for a subset of 46 cases infection can progress to viral pneumonia and a variety of complications including acute lung 47 targetable activities for COVID-19, the coronavirus Mpro seems a likely choice for rapid drug 66 To accelerate drug development we employed a drug repurposing strategy, an approach of utilizing 68 previously approved drugs for new indications 12,13 . Based upon previous successful antiviral drug development for HIV-1 and hepatitis C, the SARS-CoV-2 main protease (Mpro) appears an attractive target for drug development. keywords: compounds; drug; mpro; protease; repurposing; sars; screen cache: cord-332271-slouuryl.txt plain text: cord-332271-slouuryl.txt item: #167 of 196 id: cord-333122-xw8o189s author: Blasiak, A. title: IDentif.AI: Artificial Intelligence Pinpoints Remdesivir in Combination with Ritonavir and Lopinavir as an Optimal Regimen Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) date: 2020-05-08 words: 5141 flesch: 39 summary: Harnessing Artificial Intelligence to Rapidly Optimize Combination Therapy Development for Infectious Disease Intervention Artificial intelligence in cancer therapy Prediction of multidimensional drug dose responses based on measurements of drug pairs Enhanced identification of synergistic and antagonistic emergent interactions among three or more drugs Optimizing drug combinations against multiple myeloma using a quadratic phenotypic optimization platform (QPOP) Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore Maximizing Efficiency of Artificial Intelligence-Driven Drug Combination Optimization through Minimal Resolution Experimental Design Modulating BET Bromodomain Inhibitor ZEN-3694 and Enzalutamide Combination Dosing in a Metastatic Prostate Cancer Patient Using CURATE.AI, an Individualizing liver transplant immunosuppression using a phenotypic personalized medicine platform Application of an ex-vivo drug sensitivity platform towards achieving complete remission in a refractory T-cell lymphoma Systematic quantitative characterization of cellular responses induced by multiple signals It's time to talk about ditching statistical significance Coronavirus puts drug repurposing on the fast track Clinical Pharmacology Perspectives on the Antiviral Activity of Azithromycin and Use in COVID-19 Pharmacologic Treatments for Coronavirus Disease Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) AI to leverage unexpected drug-dose interactions to identify optimal drug combinations from a massive drug-dose search space. keywords: author; combination; drug; funder; identif.ai; license; medrxiv; perpetuity; preprint; review cache: cord-333122-xw8o189s.txt plain text: cord-333122-xw8o189s.txt item: #168 of 196 id: cord-333381-wz70o9tt author: Liu, Shao title: Providing pharmacy services during the coronavirus pandemic date: 2020-03-28 words: 3201 flesch: 36 summary: The pharmacy system aims to establish mechanisms to address drug shortages through surveillance, early warnings, drug emergency supply and distribution, monitoring the safe use of medications, and event-driven pharmaceutical care during the coronavirus epidemic [4] . To assist clinicians in better understanding and prescribing these drugs, pharmacists applied evidence-based medication use evaluation approaches to collect and summarize drug information with these recommended drugs. keywords: china; coronavirus; covid-19; drug; epidemic; pharmaceutical; pharmacists; pharmacy; public cache: cord-333381-wz70o9tt.txt plain text: cord-333381-wz70o9tt.txt item: #169 of 196 id: cord-334170-85x5vmyi author: Masoudi-Sobhanzadeh, Yosef title: Synthetic repurposing of drugs against hypertension: a datamining method based on association rules and a novel discrete algorithm date: 2020-07-16 words: 6509 flesch: 51 summary: Beside taking advantage of drug repurposing, The synthetic repurposing of Drugs, in which instead of recommending a specific drug, a combination of two or more medicines is prescribed, might yield various advantages as follows: i) Most of these patients who are from the low and middle-paid countries [6] , need some proper therapeutic plans such as drug repurposing methods which could yield the desired effect [7] . keywords: algorithms; data; drug; method; number; repurposing; results; score; synthetic; targets; trader cache: cord-334170-85x5vmyi.txt plain text: cord-334170-85x5vmyi.txt item: #170 of 196 id: cord-334511-lx9608vy author: Emwas, Abdul-Hamid title: NMR as a “Gold Standard” Method in Drug Design and Discovery date: 2020-10-09 words: 29290 flesch: 43 summary: Furthermore, the slow time scale of NMR relaxation allows the user to manipulate the external conditions (i.e., length and power of pulse) to increase the resolution of targets and potential drugs [155] in NMR drug design experiments. However, this slow timescale also sets the lower limit at which NMR drug design experiments can be performed [155] , meaning that any external manipulations cannot decrease experimental time below a certain threshold. keywords: approach; binding; chemical; data; design; diffusion; discovery; drug; drug design; drug discovery; example; experiments; fragment; interactions; ligand; methods; molecules; nmr; nmr experiments; nmr spectra; nmr spectroscopy; noe; nuclear; nuclei; protein; pulse; relaxation; resonance; screening; signal; spectra; spin; state; std; std nmr; structure; studies; target; techniques; time; use cache: cord-334511-lx9608vy.txt plain text: cord-334511-lx9608vy.txt item: #171 of 196 id: cord-334881-x9nxxled author: Di Lorenzo, Giuseppe title: COVID 19 therapies and anti-cancer drugs: A systematic review of recent literature date: 2020-05-21 words: 3254 flesch: 35 summary: key: cord-334881-x9nxxled authors: Di Lorenzo, Giuseppe; Di Trolio, Rossella; Kozlakidis, Zisis; Busto, Giuseppina; Ingenito, Concetta; Buonerba, Luciana; Ferrara, Claudia; Libroia, Annamaria; Ragone, Gianluca; Ioio, Concetta dello; Savastano, Beatrice; Polverino, Mario; De Falco, Ferdinando; Iaccarino, Simona; Leo, Emilio title: COVID 19 therapies and anti-cancer drugs: A systematic review of recent literature date: 2020-05-21 journal: Crit Rev Oncol Hematol DOI: 10.1016/j.critrevonc.2020.102991 sha: doc_id: 334881 cord_uid: x9nxxled BACKGROUND: It is reasonable to think that cancer patients undergoing chemotherapy, targeted therapy or immunotherapy could have a more aggressive course if positive for Coronavirus disease CoV-2 (COVID- 19). Thus, during this COVID-19 crisis, cancer patients are regarded as a highly vulnerable group. keywords: cancer; coronavirus; covid-19; disease; drugs; patients; study; therapy; treatment cache: cord-334881-x9nxxled.txt plain text: cord-334881-x9nxxled.txt item: #172 of 196 id: cord-336554-n8n5ii5k author: Singh, Thakur Uttam title: Drug repurposing approach to fight COVID-19 date: 2020-09-05 words: 13068 flesch: 39 summary: Further, darunavir has been used (600 mg tablet every 12 h) along with other anti-viral drugs and supportive therapy in the clinical management of COVID-19 patients presented with a range of MEWS from less than 3 to more than 4 in Italy [33] . Hydroxychloroquine phosphate (400 mg tablet every 12 h as a loading dose followed 200 mg tablet every 12 h for 10 days) or chloroquine phosphate (250 mg of two tablet every 12 h for 10 days) along with other anti-viral drugs and supportive therapy have been used in the clinical management of COVID-19 patients presented with a range of MEWS from less than 3 to more than 4 in Italy keywords: antiviral; arbidol; clinical; coronavirus; cov2; covid-19; disease; dose; drug; effects; hydroxychloroquine; infection; inhibitors; interferon; lopinavir; patients; protease; remdesivir; ribavirin; ritonavir; sars; study; therapy; tocilizumab; treatment; trial; use cache: cord-336554-n8n5ii5k.txt plain text: cord-336554-n8n5ii5k.txt item: #173 of 196 id: cord-337738-2qck1j1w author: Martin, Jennifer H. title: Buying time: Drug repurposing to treat the host in COVID‐19H date: 2020-06-23 words: 1475 flesch: 37 summary: It focuses on an alternative approach to the scientific discovery of treatments for individual patients, reviews the mechanisms of action and clinical experience with specific drugs that might be useful, and considers whether or not recent lessons regarding this bottom up approach to treatment have been learned. COVID19, drug repurposing, global collaboration, host response, renin-angiotensin 2 of 3 | COMMENTARY a further 1-5 years to complete necessary studies, and finalise the regulatory pharmaceutics dossier, but even then, time is still needed to find funding to manufacture, upscale, and develop supply lines to roll it out globally. An approach based on treating the host built on sound physiology and pathophysiology, together with thorough administrative data input and accepted principles of drug repurposing based upon pharmacology and clinical pharmacology is needed. keywords: health; host; repurposing; time cache: cord-337738-2qck1j1w.txt plain text: cord-337738-2qck1j1w.txt item: #174 of 196 id: cord-342588-berrojmq author: Burri, Christian title: Sleeping Sickness at the Crossroads date: 2020-04-08 words: 5882 flesch: 42 summary: The need for a lumbar puncture was, for over 50 years, a characteristic of HAT treatment, a source of patient distress, stigma and technical limitation of treatment. The changes and significant impact on funding were later summarized in the landmark publication the new landscape of neglected disease drug development [12] . keywords: african; control; development; disease; drug; elimination; gambiense; hat; patients; sickness; treatment; trypanosomiasis cache: cord-342588-berrojmq.txt plain text: cord-342588-berrojmq.txt item: #175 of 196 id: cord-342756-rgm9ffpk author: Senger, Mario Roberto title: COVID-19: molecular targets, drug repurposing and new avenues for drug discovery date: 2020-10-02 words: 16157 flesch: 39 summary: Structure-based virtual screening and molecular dynamics simulation of SARS-CoV-2 Guanine-N7 methyltransferase (nsp14) for identifying antiviral inhibitors against COVID-19 Virtual screening, ADME/T, and binding free energy analysis of anti-viral, anti-protease, and anti-infectious compounds against NSP10/ NSP16 methyltransferase and main protease of SARS CoV-2 Targeting SARS-COV-2 non-structural protein 16: a virtual drug repurposing study Ready, set, fuse! (148) Other targets -Apart from SARS-CoVs infection, some relevant molecular targets of other viral diseases and host metabolism have also been investigated in COVID-19 drug discovery, such as viral neuraminidases and the DPP4 cell receptor. keywords: ace2; activity; cells; coronavirus; cov-2; covid-19; disease; drug; fig; host; human; infection; inhibitors; lopinavir; mers; new; patent; patients; potential; protease; protein; remdesivir; replication; repurposing; ritonavir; rna; sars; structure; studies; syndrome; target; treatment; trials cache: cord-342756-rgm9ffpk.txt plain text: cord-342756-rgm9ffpk.txt item: #176 of 196 id: cord-343620-64i1balq author: Darvishi, Behrad title: Preparation and Antibacterial Activity Evaluation of 18-β-glycyrrhetinic Acid Loaded PLGA Nanoparticles date: 2015 words: 4316 flesch: 38 summary: Encapsulation efficiency, drug loading, size, polydispersity index and zeta potential of GLA loaded NPs are reported in Table1. Scanning electron microscopy SEM micrograph of GLA loaded NPs showed that NPs are roughly spherical and have smooth surfaces (Figure 2 ). keywords: drug; gla; loaded; nanoparticles; nps; phase; plga; polymer; release; size cache: cord-343620-64i1balq.txt plain text: cord-343620-64i1balq.txt item: #177 of 196 id: cord-344934-m0q7rm6z author: Mahapatra, Sovesh title: Repurposing Therapeutics for COVID-19: Rapid Prediction of Commercially available drugs through Machine Learning and Docking date: 2020-04-07 words: 3882 flesch: 52 summary: Another decade, another coronavirus novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2 Origin and evolution of pathogenic coronaviruses Clinical features of patients infected with 2019 novel coronavirus in Wuhan Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin Coronavirus Infections-More Than Just the Common Cold Viral and Bacterial Etiology of Acute Febrile Respiratory Syndrome among Patients in Qinghai Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Pathogen genomics in public health Severe acute respiratory syndrome-related coronavirus -The species and its viruses, a statement of the Coronavirus Study Group A family cluster of SARS-CoV-2 infection involving 11 patients in Nanjing A novel coronavirus from patients with pneumonia in China An updated estimation of the risk of transmission of the novel coronavirus (2019-nCov) Machine Learning in Virtual Screening Predicting phospholipidosis using machine learning Structure-based virtual screening for drug discovery: A problem-centric review Virtual screening of bioassay data PubChem's BioAssay database DrugBank: A knowledgebase for drugs, drug actions and drug targets Protein Data Bank. This database of more than 4900 Drugs is categorized into many different types as Trial stages Drugs, Approved Drugs and Withdrawn Drugs. keywords: april; coronavirus; dataset; drugs; medrxiv; model; preprint; sars cache: cord-344934-m0q7rm6z.txt plain text: cord-344934-m0q7rm6z.txt item: #178 of 196 id: cord-345059-t6hojshj author: Bayoumy, A. B. title: Unrealized potential of drug repositioning in europe during COVID-19 and beyond: a physcian’s perspective date: 2020-07-17 words: 5425 flesch: 42 summary: The advantages of drug repositioning are that it benefits patients and that it adds new indications to existing drugs for lower costs compared to de novo drug development. The current framework for drug repositioning allows “venture capital” companies to abuse loopholes in the legislation to gain long-term market authorization among with excessive high pricing. keywords: authorization; covid-19; data; drug; drug repositioning; market; orphan; patients; repositioning; thalidomide; treatment cache: cord-345059-t6hojshj.txt plain text: cord-345059-t6hojshj.txt item: #179 of 196 id: cord-347579-aqgauumt author: Csete, Joanne title: United States drug courts and opioid agonist therapy: Missing the target of overdose reduction date: 2020-06-09 words: 4142 flesch: 48 summary: The investigative media outlet ProPublica reported that in hundreds of drug courts across the country, Vivitrol is the only medication on offer and even some where those who refuse to take it are excluded from drug court (MacGillis, 2017) . The Drug Policy Alliance, a prominent NGO in the US drug policy reform scene, concludes that drug courts make the criminal justice system more punitive, not less: Drug courts have adopted the disease model of addiction but continue to penalize relapse with incarceration…. keywords: agonist; courts; drug; methadone; opioid; overdose; therapy; treatment; use cache: cord-347579-aqgauumt.txt plain text: cord-347579-aqgauumt.txt item: #180 of 196 id: cord-347986-ds5hm731 author: Lee, Paul J. title: Developing Infectious Disease Strategies for the Developing World date: 2007-01-26 words: 4106 flesch: 47 summary: A Beijing/W genotype strain, which has developed resistance to both first and second line TB drugs, is of particular concern. Its activity appears to be directed against mycobacterial ATP synthase, giving it a unique mechanism of action, compared with other tuberculosis drugs, including fluoroquinolones like moxifloxacin. keywords: drugs; human; infections; influenza; phase; strain; treatment; tuberculosis cache: cord-347986-ds5hm731.txt plain text: cord-347986-ds5hm731.txt item: #181 of 196 id: cord-348102-k0s9j9sz author: Silvestris, Nicola title: On the Management of Drug Interactions in the Course of Concomitant Treatments for COVID-19 and Antineoplastic Agents date: 2020-07-21 words: 1017 flesch: 20 summary: (6) may redundantly influence the pharmacokinetics and pharmacodynamics of cancer drugs (e.g., chemotherapy, hormonotherapy, targeted therapy, and immunotherapy) remains an object of investigation (7) . The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects Important drug-drug interactions in HIV-infected persons on antiretroviral therapy: an update on new interactions between HIV and Non-HIV drugs Ribociclib + letrozole for first-line treatment of HR+, HER2-ABC: efficacy, safety, and pharmacokinetics Management of adverse events during cyclin-dependent kinase 4/6 (CDK4/6) inhibitor-based treatment in breast cancer P-glycoprotein limits ribociclib brain exposure and CYP3A4 restricts its oral bioavailability Role of transporters in the distribution of platinumbased drugs P-glycoprotein mediated drug interactions in animals and humans with cancer Drug interaction database sensitivity with oral antineoplastics: an exploratory analysis Systematic review of the efficacy and safety of antiretroviral drugs against SARS, MERS or COVID-19: initial assessment keywords: covid-19; drug; interactions; patients cache: cord-348102-k0s9j9sz.txt plain text: cord-348102-k0s9j9sz.txt item: #182 of 196 id: cord-348245-pf5mlzrw author: Moura-Neto, José A. title: Position statement from the Brazilian Society of Nephrology regarding chloroquine and hydroxychloroquine drug dose adjustment according to renal function date: 2020-08-26 words: 966 flesch: 35 summary: If the doctor chooses to use one of these drugs in the population with Chronic Kidney Disease, especially in dialysis patients, he/she must consider its long half-life (up to 40-50 days). key: cord-348245-pf5mlzrw authors: Moura-Neto, José A.; Misael, Ana Maria; da Silva, Dirceu Reis; D’Avila, Ronaldo; Andreoli, Maria Claudia Cruz; Kraychete, Angiolina; Bastos, Kleyton; do Nascimento, Marcelo Mazza title: Position statement from the Brazilian Society of Nephrology regarding chloroquine and hydroxychloroquine drug dose adjustment according to renal function date: 2020-08-26 journal: J Bras Nefrol DOI: 10.1590/2175-8239-jbn-2020-s113 sha: doc_id: 348245 cord_uid: pf5mlzrw Chloroquine and hydroxychloroquine have shown promising preliminary results and have been discussed as therapeutic options for patients with Covid-19. keywords: chloroquine; hydroxychloroquine; patients; renal cache: cord-348245-pf5mlzrw.txt plain text: cord-348245-pf5mlzrw.txt item: #183 of 196 id: cord-349682-kpg0vley author: Ojha, Probir Kumar title: Therapeutics for COVID-19: from computation to practices—where we are, where we are heading to date: 2020-09-02 words: 7951 flesch: 40 summary: Repurposing drugs against main protease of SARS-CoV-2: mechanism based insights supported by available laboratory and clinical data Identification of potential inhibitors of SARS-CoV2 main protease via a rapid in-silico drug repurposing approach In silico screening of Chinese herbalmedicines with the potential to directly inhibit 2019 novel coronavirus Analysis of therapeutic targets for SARS-CoV2 and discovery of potential drugs by computational methods Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV2) through a drug-target interaction deep learning model Computational search for potential COVID-19 drugs from FDA-approved drugs and small molecules of natural origin identifies several anti-virals and plant products Identification of SARS-CoV2 cell entry inhibitors by drug repurposing using in silico structure-based virtual screening approach Prediction of the SARS-CoV2 (2019-nCoV) 3C-like protease (3CL pro ) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates Comparative computational study of SARS-CoV2 receptors antagonists from already approved drugs Investigation into SARS-CoV-2 resistance of compounds in garlic essential oil In-silico studies of antimalarialagent artemisinin and derivatives portray more potent binding to Lys353 and Lys31-binding hotspots of SARS-CoV2 spike protein than hydroxychloroquine: potential repurposing of artenimol for COVID-19 Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV2 infection Destabilizing the structural integrity of SARS-CoV2 receptor proteins by curcumin along with hydroxychloroquine: an insilco approach for a combination therapy Identification of potential molecules against COVID-19 main protease through structure-guided virtual screening approach Development of a simple, interpretable and easily transferable QSAR model for quick screening antiviral databases in search of novel 3Clike protease (3CLpro) enzyme inhibitors against SARS-CoV diseases Computational screening for potential drug candidates against the SARS-CoV-2 main protease Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease Protein reliability analysis and virtual screening of natural inhibitors for SARS-CoV-2 main protease (Mpro) through docking, molecular mechanic & dynamic, and ADMET Profiling. Table 1 Drug candidates under trial against COVID-19 with probable targets, mechanism of action, pathophysiology, application and current status [11, 12, 14, 30, 40, 43, 45, 53, 55, Drug candidates under trial The SARS-CoV-2 uses the S protein to facilitate viral entry into the host cells. keywords: ace2; cell; clq; coronavirus; cov-2; covid-19; drug; fig; host; human; inhibitors; patients; potential; protease; protein; receptor; sars; treatment; trial cache: cord-349682-kpg0vley.txt plain text: cord-349682-kpg0vley.txt item: #184 of 196 id: cord-349794-mhviub6e author: Le, Brian L. title: Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19 date: 2020-10-23 words: 3814 flesch: 35 summary: Using a rank-based pattern matching strategy based on the Kolmogorov-Smirnov Statistic, the signatures were queried against drug profiles from Connectivity Map (CMap). Here, we applied our existing computational drug repositioning pipeline to identify drug profiles with significantly reversed differential gene expression compared to predicted inhibitors (including one tested in Calu-3) were incubated with SARS-CoV-2 infected human embryonic kidney 293T cells overexpressing ACE2 (293T-ACE2) with viral replication determined using an immunofluorescence-based assay. keywords: cells; cov-2; covid-19; data; drug; expression; gene; hits; human; sars; signature cache: cord-349794-mhviub6e.txt plain text: cord-349794-mhviub6e.txt item: #185 of 196 id: cord-350571-6tapkjb6 author: None title: 45th ESCP-NSF international symposium on clinical pharmacy: clinical pharmacy tackling inequalities and access to health care. Oslo, Norway, 5–7 October 2016 date: 2017-01-10 words: 106086 flesch: 45 summary: Clinical pharmacists have a role to evaluate and optimize the appropriateness and effectiveness of patient's medications. DTSIs interventions (treatment group) consist in: motivational interview, sharing and delivery of printed, explanatory material in the patient's native language, reconciliation of patients medications at hospital admission and at discharge; identification of potential risks due to drug-drug interactions; monitoring of compliance to drug therapy, and finally detection of adverse drug reactions (ADRs) occurring in the course of care. keywords: abstract; adherence; administration; admission; age; aim; analysis; antibiotics; assessment; associated; average; background; cancer; care; cases; clinical; community; conclusion; control; criteria; data; day; days; department; design; discharge; discrepancies; disease; dispensing; dosage; dose; drug; effects; following; general; group; guidelines; health; home; hospital; hospital pharmacy; impact; increase; information; interactions; interventions; knowledge; level; main; management; mean; measures; median; medical; medication; medication adherence; medication reconciliation; medicines; method; monitoring; months; n =; non; number; nurses; objective; oral; order; outcome; outcome measures; patients; period; pharmaceutical; pharmacists; pharmacy; physicians; potential; practice; prescribed; prescription; problems; process; projects; quality; research; results; review; risk; risk patients; role; safety; score; service; setting; study; survey; team; therapy; time; total; treatment; type; university; use; years cache: cord-350571-6tapkjb6.txt plain text: cord-350571-6tapkjb6.txt item: #186 of 196 id: cord-350703-vrqltz3s author: None title: ISAR News date: 2016-01-31 words: 11208 flesch: 42 summary: I would like to contribute to the field of antiviral drug development by identifying new targets for prevention or treatment. They will each work on their own projects, which aim to gain insight into antiviral drug development for a selected group of viruses. keywords: antiviral; chemistry; committee; dengue; development; discovery; drug; ebola; hepatitis; icar; inhibitors; institute; isar; members; novel; program; research; science; treatment; university; virology; virus; viruses; work; years; young cache: cord-350703-vrqltz3s.txt plain text: cord-350703-vrqltz3s.txt item: #187 of 196 id: cord-351185-3y3gou6v author: Buckles, Thomas C. title: Rapid exposure of macrophages to drugs resolves four classes of effects on the leading edge sensory pseudopod: Non-perturbing, adaptive, disruptive, and activating date: 2020-05-29 words: 10076 flesch: 39 summary: The microscopic field observed following drug addition in single cell and population measurements represented a small fraction (< 0.2% and < 6%, respectively) of the 8 x 8 mm 2 glass surface area in the observation well. Panels A through D images show representative effects of drug addition on the leading edge pseudopod: (A,B) DICM images of a single cell at t = 0 and 5 min after ibuprofen addition, respectively, illustrating the drug-triggered loss of leading edge pseudopod area; (C,D) fluorescence images of the PIP 3 sensor AKTPH-mRFP in a single cell at t = 0 and 5 min after wortmannin addition, respectively [26, 30] illustrating the drug-triggered loss of the signaling lipid PIP 3 on the leading edge pseudopod. keywords: acetaminophen; adaptation; addition; cell; collapse; concentration; control; drug; edge; effects; fig; ibuprofen; macrophages; pip; plasma; pseudopod; total cache: cord-351185-3y3gou6v.txt plain text: cord-351185-3y3gou6v.txt item: #188 of 196 id: cord-351222-9bfchw4u author: Rollinger, Judith M. title: Virtual screening for the discovery of bioactive natural products date: 2008 words: 10023 flesch: 34 summary: An idealized computer experiment SARS-CoV protease inhibitors design using virtual screening method from natural products libraries Sabadinine: a potential nonpeptide anti-severe acute-respiratory-syndrome agent identified using structure-aided design Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application Structure-based virtual screening for plant-based ER -selective ligands as potential preventative therapy against age-related neuro-degenerative diseases Structure-based discovery of potassium channel blockers from natural products virtual screening and electrophysiological assay testing Pharmacophore modelling: applications in drug discovery Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B Rational selection of structurally diverse natural product scaffolds with favorable ADME properties for drug discovery Drugs? Some strategies and examples from literature combining virtual screening approaches and classical methods for activity exploitation are outlined below. keywords: activity; approach; authors; compounds; database; discovery; docking; drug; information; ligand; model; nps; pharmacophore; protein; screening; structure; target cache: cord-351222-9bfchw4u.txt plain text: cord-351222-9bfchw4u.txt item: #189 of 196 id: cord-351517-npcuo1ld author: Gale, Robert Peter title: Liaisons Dangereuses? new drugs, physicians and the drug industry date: 2020-07-01 words: 2295 flesch: 50 summary: In contrast, consider a world where drug companies do not develop new drugs for the diseases we need to treat. Our lives would be entirely different if drug companies developing and promoting new drugs ceased to exist. keywords: approvals; companies; drug; new; physicians; research; survival; transplant cache: cord-351517-npcuo1ld.txt plain text: cord-351517-npcuo1ld.txt item: #190 of 196 id: cord-352579-ndcbmgfj author: Takahashi, Takuto title: Pharmacogenomics of COVID-19 therapies date: 2020-08-18 words: 5264 flesch: 28 summary: In conclusion, although direct evidence in COVID-19 patients is lacking, we identified potential actionable genetic markers in COVID-19 therapies. Clinical studies in COVID-19 patients are deemed warranted to assess potential roles of these markers. keywords: azithromycin; covid-19; drug; hydroxychloroquine; lopinavir; patients; pharmacogenomics; ribavirin; risk; tocilizumab; treatment; use; variants cache: cord-352579-ndcbmgfj.txt plain text: cord-352579-ndcbmgfj.txt item: #191 of 196 id: cord-353524-3w970ycx author: Dömling, Alexander title: Chemistry and Biology of SARS-CoV-2 date: 2020-05-22 words: 3961 flesch: 46 summary: Several approved HIV protease inhibitors (15, 16, and 18) were previously repurposed for the treatment of SARS (Scheme 2). The reported case-fatality rate of COVID-19 is %3% and is thus rather low as compared with SARS (30% , Table 1 ). keywords: coronavirus; cov-2; covid-19; drug; inhibitors; potential; protease; protein; rna; sars cache: cord-353524-3w970ycx.txt plain text: cord-353524-3w970ycx.txt item: #192 of 196 id: cord-353572-b4mdiont author: Zhou, Yadi title: Network-based Drug Repurposing for Human Coronavirus date: 2020-02-05 words: 6905 flesch: 38 summary: Mesalamine induced eosinophilic pneumonia Molecular Evolutionary Genetics Analysis across Computing Platforms Enrichr: a comprehensive gene set enrichment analysis web server 2016 update DrugBank 4.0: shedding new light on drug metabolism Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands UniProt: the Universal Protein knowledgebase Studying tumorigenesis through network evolution and somatic mutational perturbations in the cancer interactome A Gene Gravity Model for the Evolution of Cancer Genomes: A Study of 3,000 Cancer Genomes across 9 Cancer Types Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target Specifically, the envelope and nucleocapsid proteins of 2019-nCoV are two evolutionarily conserved regions, having the sequence identities of 96% and 89.6%, respectively, compared to SARS-CoV. Using network proximity analyses of drug targets and known HCoV-host interactions in the human protein-protein interactome, we computationally identified 135 putative repurposable drugs for the potential prevention and treatment of HCoVs. keywords: drug; figure; hcov; host; human; license; medrxiv; medrxiv preprint; network; perpetuity; preprint; protein; targets; virus cache: cord-353572-b4mdiont.txt plain text: cord-353572-b4mdiont.txt item: #193 of 196 id: cord-354006-j1y42oxu author: Ozdemir, Vural title: Shifting emphasis from pharmacogenomics to theragnostics date: 2006 words: 4202 flesch: 26 summary: In the present analyses, we 'unpack' and contrast the motivations at play that are driving the pursuit for theragnostic patents and its bioethical corollaries in: (1) fundamental upstream basic research oriented to the discovery of genes for human diseases; and (2) downstream clinical applications at point-of-care as theragnostic tests to stratify patient populations for individualization of pharmacotherapy. Therefore, the pursuit of theragnostic patents can also be shaped by the type of industry setting (e.g., diagnostic sector versus large pharma) as well as the type of pharmaceutical (e.g., me-too drugs) associated with theragnostic tests. keywords: biomarker; development; disease; drug; gene; myriad; patents; research; tests cache: cord-354006-j1y42oxu.txt plain text: cord-354006-j1y42oxu.txt item: #194 of 196 id: cord-354180-6esn3t2b author: Tyndall, Mark title: Safer opioid distribution in response to the COVID-19 pandemic date: 2020-07-27 words: 4227 flesch: 51 summary: It has become obvious to those who are most impacted by the overdose crisis that nothing short of providing access to safer opioid drugs will reduce overdoses (Fischer & Pang & Tyndall, 2019) . Drug overdose has always been a risk for people who relied on an unregulated street market for their drugs. keywords: covid-19; deaths; drugs; opioid; overdose; people; reduction; supply; use cache: cord-354180-6esn3t2b.txt plain text: cord-354180-6esn3t2b.txt item: #195 of 196 id: cord-354445-lnvc7mmf author: Lichtenstein, David title: 4 Cleaning and Disinfecting Gastrointestinal Endoscopy Equipment date: 2019-12-31 words: 13660 flesch: 32 summary: An investigation using molecular epidemiology A prospective analysis of fever and bacteremia following ERCP Polymicrobial sepsis following endoscopic retrograde cholangiopancreatography Infection control practices in gastrointestinal endoscopy in the United States: a national survey Iatrogenic Campylobacter pylori infection is a cause of epidemic achlorhydria Development and validation of rapid use scope test strips (RUST) to determine the efficacy of manual cleaning for flexible endoscope channels Rapid method for the sensitive detection of protein contamination on surgical instruments The ATP test is a rapid and reliable audit tool to assess manual cleaning adequacy of flexible endoscope channels Validation of ATP to audit manual cleaning of flexible endoscope channels Persistent contamination on colonoscopes and gastroscopes detected by biologic cultures and rapid indicators despite reprocessing performed in accordance with guidelines Assessing residual contamination and damage inside flexible endoscopes over time Simulated-use validation of a sponge ATP method for determining the adequacy of manual cleaning of endoscope channels Validation and comparison of three adenosine triphosphate luminometers for monitoring hospital surface sanitization: a Rosetta Stone for adenosine triphosphate testing The use of rapid indicators for the detection of organic residues on clinically used gastrointestinal endoscopes with and without visually apparent debris The compliance of reprocessing personnel with endoscope reprocessing protocols should be reviewed at least annually to document ongoing competency. keywords: channels; cleaning; control; devices; disinfection; duodenoscopes; endoscope; fda; guidelines; health; hld; level; manual; patient; procedures; reprocessing; risk; sterilization; time; transmission; use; water cache: cord-354445-lnvc7mmf.txt plain text: cord-354445-lnvc7mmf.txt item: #196 of 196 id: cord-355971-99mhacqa author: Gougis, Paul title: Anticancer drugs and COVID-19 antiviral treatments in cancer patients: what can we safely use? date: 2020-06-10 words: 761 flesch: 31 summary: key: cord-355971-99mhacqa authors: Gougis, Paul; Fenioux, Charlotte; Funck-Brentano, Christian; Veyri, Marianne; Gligorov, Joseph; Solas, Caroline; Spano, Jean-Philippe title: Anticancer drugs and COVID-19 antiviral treatments in cancer patients: what can we safely use? date: 2020-06-10 journal: Eur J Cancer DOI: 10.1016/j.ejca.2020.05.027 sha: doc_id: 355971 cord_uid: 99mhacqa • More safety data is needed to treat COVID-19 symptomatic patients with anticancer drugs known to increase infections. keywords: anticancer; drugs; interactions cache: cord-355971-99mhacqa.txt plain text: cord-355971-99mhacqa.txt